CABT-B11601

antibody from Creative Diagnostics

Targeting: TDP1 FLJ11090, SCAN1

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Antibody Data

Product number

CABT-B11601

Provider

Creative Diagnostics

Product name

Mouse anti-Human TDP1 monoclonal antibody, clone 3B21H3

Antibody type

Monoclonal

Description

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq, Jul 2008]

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3B21H3

Vial size

100 _g

Storage

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.