SEPTIN7

This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. [provided by RefSeq, Jul 2011]

Description

Septin 7

Tissue specificity

Tissue enhanced (brain)

Subcell location

Nucleoli, Plasma membrane, Actin filaments, Midbody, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (35800932 - 35907105)

Ensembl ID

ENSG00000122545  (ver. 103.38)

Orthologs

Mouse Septin7: ENSMUSG00000001833

UniProt

Q16181

neXtProt

NX_Q16181

Human splice variants
Mouse splice variants

Protein structure