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- References [1638]
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- Product number
- 10701-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10701-1-AP, RRID:AB_2118685
- Product name
- HO-1/HMOX1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HO-1/HMOX1 antibody (Cat. #10701-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of autophagy-related key biomarkers in caerulein induced acute pancreatitis: In silico and in vivo study.
Spatholobus suberectus Stem-Derived Extracellular Vesicle-Like Particles Attenuate Glucocorticoid-Induced Osteoporosis via NRF2/HO-1 Signaling.
Effect of Cordyceps militaris Extract on Visceral Adipose Tissue Changes After Ovariectomy in Rodents.
Gan-Pi-Tong-Zhi Decoction Ameliorates OVA-Induced Asthma Through MAPK and Nrf2 Signaling Pathways and Regulating Gut Microbiota.
Artificial neural network-based analysis of ferroptosis-associated molecular subtypes and immunological profiles in abdominal aortic aneurysm.
Multitarget mechanisms of the herb pair Achyranthes bidentata and Paeonia lactiflora Pall. in ameliorating hypertensive cardiomyopathy: combining network pharmacology and functional exploration.
ROS-Responsive Double-Layer Microneedles Enable Sequential Antibacterial and Immunomodulatory Therapy for Infected Wound Healing.
Processed phellodendri Chinensis cortex attenuates diabetic nephropathy via ferroptosis inhibition through GPX4/SLC7A11/Nrf2/HO-1 signaling pathway.
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Cannabidiol attenuates methamphetamine-induced psychosis via anti-oxidative stress: σ1R-mediated mitochondrial dysfunction as a critical pathway.
Macrophage Membrane-Cloaked, ROS-Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome.
Mechanism of Bushen Wenyang Huayu Formula against oxidative damage by Let-7b-Bach1 in the treatment of endometriosis.
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota.
Hepatitis C virus p7 regulates Core protein processing via signal peptide peptidase to promote virion assembly.
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1.
Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity.
TPPU alleviates hepatic ischemia-reperfusion injury by regulating macrophage polarization.
M2 macrophage-derived exosome nanoplatform for targeted H(2)S delivery to alleviate hepatic ischemia-reperfusion injury via synergistic anti-oxidative, anti-inflammatory, and anti-ferroptotic effects.
Inhibition of Nrf2 Activity in Mitigating Cadmium-Induced Mitochondrial Damage and Pyroptosis.
Crebanine protects against ovariectomy-induced bone loss by targeting Sirt1 to interfere with NF-κB acetylation and ROS activity.
Multi-omics mapping identifies CYBA-mediated mitochondrial dysfunction driving macrophage polarization and ferroptosis via Nrf2 pathway in atherosclerosis.
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
IL-3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury.
Atractylenolide III improves ovarian dysfunction and endometrial receptivity in a PCOS rat model by regulating Cybb-mediated oxidative stress.
USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis.
Retinoic Acid Alleviates TGEV-Induced Ferroptosis by Activating the p62-NRF2-GPX4/HO-1 Pathway and Iron Metabolism in Intestinal Epithelial Cells.
P2 X 7 receptor deficiency ameliorates high-fat-induced cardiac remodeling by improving oxidative stress through PI3K/AKT/GSK3β-mediated regulation of Nrf2.
Dual action of SS31 via NRF2/HO-1: countering oxidative stress and metabolic dysfunction in ovarian aging.
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Ethanol extract of Gastrodia elata Blume alleviates ischemic stroke by inhibiting oxidative stress and ferroptosis through the PI3K/AKT/Nrf2 pathway.
Mesenchymal Stem Cell-Lysate Sustained-Release Nano-Hydrogel Alleviates Spinal Cord Injury by Inhibiting Ferroptosis and Mitochondrial Intrinsic Apoptosis.
Protean bio-heterojunction nanoparticle coating for dynamically modulating diabetic microenvironment.
SIRT1 protects against UVA-induced photoaging by suppressing oxidative stress and FOXO3a acetylation in human dermal fibroblasts.
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Enterolactone mitigates atherosclerosis by facilitating resolution of ferroptosis-associated intimal inflammation via the Keap1/Nrf2/GPX4 pathway.
Farrerol mitigates fungal keratitis by enhancing fungal clearance and limiting inflammation through autophagy and Nrf2 pathway.
The Berberine Derivative BBR684 Inhibits VDAC Oligomerization to Suppress Ferroptosis in Acute Kidney Injury.
Investigation of the Potential Anti-Diabetic Kidney Disease Mechanism of Gynura procumbens (Lour.) Merr via Transcriptomics Combined With Network Pharmacology.
6-Gingerol alleviates NNK-induced lung carcinogenesis by boosting antioxidation and reducing inflammation.
CDKN3 promoted triple-negative breast cancer by inhibiting ferroptosis through the upregulation of HSP90.
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
Neuroprotective effects of SRS11-92 against oxidative stress-induced senescence via Nrf2/HO-1/NF-κB in Alzheimer's disease models.
Mechanism of tectorigenin in promoting thermal burn wound healing via the Nrf2-mediated ferroptosis pathway: Integrated pharmacological and experimental study.
Structural characterization and multi-omics analysis of novel Saposhnikovia divaricata (Turcz.) Schischk acidic heteropolysaccharide alleviating acute liver injury.
High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE(‑/‑) mice via the NAD(+)‑mediated SIRT1/MFN2 pathway.
Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway.
Ammonium tetrathiomolybdate ameliorates heat stroke-induced murine liver injury by activating the Nrf2/HO-1 signaling pathway and inhibiting oxidative stress.
Eugenol attenuates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the Nrf2/GPX4 pathway.
SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization.
The Tetradium ruticarpum-Zingiber officinale Roscoe herb pair inhibits atherogenic events: A study of the synergistic effects and active ingredient combination of a two-herb formula.
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Justicia procumbens promotes hair growth and ameliorates age-related deterioration of hair health.
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Ononin promotes bone marrow-derived mesenchymal stem cells survival via SIRT6/Nrf2 signaling for myocardial infarction repair.
Spatial Transcriptome Analysis Reveals Factors Involved in Actinic Cheilosis Transformation to Squamous Cell Carcinoma of the Lip.
HucMSC-derived exosomes alleviate chemotherapy-induced premature ovarian insufficiency via SMURF1-mediated inhibition of ferroptosis in ovarian granulosa cells.
Chlorella-derived extracellular vesicle-based nanogels suppress cGAS-STING for treatment of radiation-induced lung injury.
Indole-3-aldehyde Preserves Gingival Epithelial Barrier Structure and Function Via AhR/Nrf2 Signaling Pathway.
Propyl Gallate Attenuates Cognitive Deficits Induced by Chronic Sleep Deprivation Through Nrf2 Activation and NF-κB Inhibition.
Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway.
Integrative multiomics analysis reveals the ameliorative effects of Xiasangju on metabolic dysfunction-associated steatohepatitis.
Binankadsurin A from Kadsura coccinea Fruits Ameliorates Acetaminophen-Induced Liver Injury Through Inhibiting Oxidative Stress by Keap1/Nrf2/HO-1 Pathway.
Chrysanthemum 3,5-O-dicaffeoylquinic acid ameliorates mouse alcoholic liver injury by suppressing the TLR-4/NF-κB pathway and restoring glycerophospholipid homeostasis.
Heme as a Pro-Inflammatory Stimulus in Abdominal Aortic Aneurysm.
LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.
ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury.
Revealing the anti-tumor mechanisms of aromatic oil from Amomum villosum through integrated network pharmacology, bioinformatics, machine learning, single-cell sequencing, and cell experiments.
Repurposing metformin for treating osteoarthritis via leveraging Nrf2 signaling.
Quercetin-chitooligosaccharide ionic complex: molecular stabilization and microbiota mediated glycemic modulation.
Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration.
Carnosic acid attenuates ventilator-induced diaphragmatic dysfunction via activation of the Nrf2/HO-1 pathway.
Nicotinamide N-methyltransferase mediates redox regulation and colonic epithelial barrier impairment by SIRT1/PPAR-γ/NLRP6/NRF2 axis in inflammatory bowel disease.
Lycium barbarum polysaccharide LBP3 alleviates 5-Fluorouracil-induced intestinal injury via a mechanism associated with activating Nrf2 and improving mitochondrial function.
Forsythoside B protects cartilage and subchondral bone in osteoarthritis by regulating the Nrf2/NF - κ B signaling pathway.
Modulation of Macrophage ferroptosis under the guide of infrared thermography promotes the healing of pressure injuries.
Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer.
Manganese oxide nanozyme-loaded CO-releasing halloysite nanotubes for remodeling colonic immune, microbiota, and intestinal barrier homeostasis with concurrent pain relief in ulcerative colitis.
Cardiac oxidative damage and mitochondrial dysfunction induced by manganese deficiency are probably associated with the inhibition of the Nrf2 signaling pathway.
Intranasal delivery of Odorranalectin-modified lipid nanoparticles for multi-targeted therapy of Alzheimer's disease.
Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice.
Cannabidiol alleviates methamphetamine-induced autophagy and oxidative stress by suppressing sigma 1 receptor expression.
Neuron-Derived Sema3B Facilitates Microglial Hematoma Clearance After Intracerebral Hemorrhage.
Design, synthesis, and neuroprotective evaluation of chiral butylphthalide-ligustrazine hybrids via the Keap1-Nrf2 pathway in ischemic stroke.
Mangosteen (Garcinia mangostana) Pericarp and Leaf Tinctures Inhibit LPS-Induced Pro-Inflammatory Responses in Macrophages and Activate Nrf2.
Scutellarin alleviates ferroptosis in cigarette smoke-induced chronic obstructive pulmonary disease via activation of the PI3K/AKT/Nrf2 signaling pathway.
The dual functions of a nor-sesquiterpene-triazole derivative against influenza A viruses through the activation of the Nrf2/HO-1 signaling pathway and interaction with hemagglutinin.
Chlorogenic acid exerts anti-inflammation and neuroprotective effect in pentylenetetrazole-induced epilepsy mouse model by regulating microglia polarization via Nrf2/HO-1 pathway.
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
Quercetin Attenuates Iron Overload-Induced Renal Injury via Activating Nrf2/xCT/GPX4 Signaling to Inhibit Ferroptosis.
A novel mechanism of chlorogenic acid against type 2 diabetes-induced diabetic retinopathy: suppressing ferroptosis via NRF2/xCT/GPX4 and STAT3 signaling.
[Veratric acid relieves oxidative stress and DSS-induced colitis in mice by activating the Nrf2/HO-1 signaling pathway].
Diosmetin, an active ingredient of Schizonepeta tenuifolia, alleviates acne by regulating inflammation and oxidative stress.
Fascin-1 Limits Secondary Damage by Preventing Oxidative‑Stress‑Induced Microglial Death After Spinal Cord Injury.
Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity.
Marine trichodermamide B inhibits prostate cancer progression via catalase inhibition-induced apoptosis.
Association and Toxic Mechanism Between Foodborne OTA Exposure and Embryonic Development.
Remimazolam alleviates acute lung injury by inhibiting ferroptosis: a multi-omics system pharmacology approach with experimental validation.
Carbon-based nanomaterials induce ovarian dysfunction via NLRP3 inflammasome-mediated pyroptosis in granulosa cells.
Antioxidant properties of low-molecular-weight Ulva prolifera polysaccharides against H₂O₂-induced oxidative damage in BRL 3A cells and zebrafish.
Inhibition of MAGL ameliorates glucocorticoid-induced bone loss by regulating the Nrf2 signaling.
Microglial HMOX1 drives retinal angiogenesis via modulation of endothelial STAT3 signaling.
An intrabody targeting PHD2 protects mice against acetaminophen-induced liver injury by attenuating ferroptosis.
USP7 deletion promotes osteoclastogenesis via stimulating NF-κB and attenuating Nrf2/HO-1 signaling pathway.
Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway.
Dibutyl phthalate exposure induces thyroid toxicity through follicular cell pyroptosis via the NRF2/KEAP1/NF-κB pathway.
Fisetin alleviates lipopolysaccharide-induced mastitis by inhibiting ferroptosis and modulating the gut microbiota.
EGCG-loaded nanoparticles attenuate post-SAH white matter injury by targeting HO-1/S100A10 to suppress oxidative stress-induced reactive astrocytes.
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.
A coenzyme-based "interface-welding" hydrogel coating for titanium implants promotes diabetic osseointegration by regulating mitochondrial dynamics.
Modified Erxian Decoction ameliorates premature ovarian insufficiency via HIF-1α-mediated regulation of mitochondrial fission and oxidative stress.
Resveratrol Attenuates Neuroinflammation and Myelination Deficits in Repeated Sevoflurane-Exposed Neonatal Mice.
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activation of the Sirt1/Nrf2/FOXO3 Signaling Pathway.
Puerarin attenuates myocardial ischemia‑reperfusion injury by inhibiting myocardium pyroptosis via the NRF2/HO‑1 signaling pathway.
Pinobanksin alleviates 4℃ semen preservation-induced oxidative damage and apoptosis in Wenchang Pig spermatozoa via the CaMKKβ/AMPK/Nrf2 pathway.
The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis.
Resveratrol dual efficacy in high-altitude hypoxia and NAFLD: inhibits ferroptosis by modulating key proteins, including HIF-1α, ACSL4, and TfR1.
Engineered Mesenchymal Stem Cells with Endogenous Trehalose Expression Activate the NRF2-HMOX1 Pathway to Enhance Antioxidant Stress and Wound Healing Capacity.
Computational-experimental integration reveals PPARγ/Nrf2-GPX4 dual-targeting by combined selenomethionine-magnolol as a novel therapy for sarcopenic obesity.
Selective Radioprotection by the Fusion Antioxidant Enzyme GS1XR Via an MMP-2/9-Cleavable Cell-Penetrating Switch.
Aerobic Exercise Alleviates Oxidative Stress and Inflammation to Attenuate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in ApoE(-/-) Mice.
The curcumin derivative DMC-GF promotes ferroptosis through the Nrf2/HMOX1 pathway, increasing glioma susceptibility to temozolomide.
Discovery of novel Keap1-targeting hydrophobic tag (HyT) tethering degraders with potent Nrf2 activation activity.
Macrophage-Targeted Nanocarriers Based on Tetrahedral DNA Nanostructure Alleviate Sepsis-Induced Acute Lung Injury by Triple-Pathway Suppression of Pyroptosis.
Notopterol attenuates atherosclerosis by promoting macrophage cholesterol efflux via targeting KEAP1/NRF2 interaction.
Heme oxygenase-1-enriched tolerogenic dendritic cell-derived exosomes attenuate lupus nephritis by restoring immune balance and iron homeostasis.
Egg white-derived metabolic regulatory peptide AD-IR10 promotes diabetic wound healing via Keap1/Nrf2/Irg1-mediated macrophage metabolic reprogramming.
Astaxanthin ameliorates allergic rhinitis via suppression of the HMGB1/TLR4 signaling pathway.
Green coffee bean extract rich in chlorogenic acids prevents muscle capillary regression via inhibiting oxidative stress and enhancing angiogenesis.
Corynoline alleviates renal ischemia-reperfusion injury by enhancing Nrf2/HO-1 pathway.
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots.
Temporal dynamics of ferroptosis markers and neuroprotective intervention in cerebral ischemia-reperfusion injury: Insights for therapeutic strategy development.
Imbalance of Bone Homeostasis Caused by Nrf2 Deficiency Leads to Bone Loss in OVX Rats.
Elucidating the Therapeutic Mechanism of Danggui Liuhuang Decoction in Hyperthyroid Kidney Disease: An Integration of Network Pharmacology and Metabolomics.
Interaction of coexposure to inorganic arsenic and manganese: Tight junction injury of the blood-brain barrier and the relationship between oxidative stress and inflammatory cytokines in glial cells.
Human umbilical cord mesenchymal stem cell-derived exosomes mitigate acute radiation-induced intestinal oxidative damage via the Nrf2/HO-1/NQO1 signaling pathway.
Silencing NRF2 enhances arsenic trioxide-induced ferroptosis in hepatocellular carcinoma cells.
Protective effect of Pinacidil on hypoxic-reoxygenated cardiomyocytes in vitro and in vivo via HIF-1α/HRE pathway.
Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury.
Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway.
Magnesium Isoglycyrrhizinate Alleviates Alectinib-Induced Hepatotoxicity by Inhibiting Mitochondrial Damage-Mediated Pyroptosis.
Sakuranetin Prevents Acetaminophen-Induced Liver Injury via Nrf2-Induced Inhibition of Hepatocyte Ferroptosis.
Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis.
IGF2BP1 Enhances Neprilysin mRNA Stability to Promote Proliferation, Invasion, and Angiogenesis in Placental Trophoblasts.
Subchronic Chlorpyrifos Exposure Induces Thyroid Follicular Cell Pyroptosis to Exacerbate Thyroid Toxicity by Modulating Nrf2/Keap1/NF-κB Pathway in Male Mice.
Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense.
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway.
Curculigoside alleviates ferroptosis in renal interstitial fibrosis by regulating the Nrf2/HO-1 signaling pathway.
Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice.
Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury.
Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk.
Exploring the mechanism of Qingre Yishen Xiaozheng formula in treating diabetic kidney disease via the HIF-1α/HO-1 signaling pathway: an integrated network pharmacology and experimental study.
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of acteoside in the treatment of diabetic nephropathy.
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway.
Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism.
Langqing Meiduo Jiujie pills treatment attenuates acute liver injury in animals by regulating anti-oxidative stress and liver metabolism.
Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway.
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury.
Magnolia kobus DC. Alleviates adenine-induced chronic kidney disease by regulating ferroptosis in C57BL/6 mice.
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the Keap1/Nrf2/HO-1 pathway.
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
A multifunctional injectable microsphere with enhanced near-infrared photo-antibacterial, ROS scavenging, and anti-inflammatory properties for periodontitis treatment.
Securinine, a novel alkaloid, regulates cell cycle and EMT in gastric cancer by inducing iron-dependent cell death.
Flufenamic acid inhibits pyroptosis in ischemic flaps via the AMPK-TRPML1-Calcineurin signaling pathway.
Novel idebenone derivatives attenuated oxidative stress injury and myocardial damage.
Injectable exosome-reinforced konjac glucomannan composite hydrogel for repairing cartilage defect: activation of endogenous antioxidant pathways.
Enhanced prevention on postoperative atrial fibrillation by using anti-inflammatory biodegradable drug patch.
Garlic oil-loaded nanodisks for the amelioration of acute lung injury via modulation of the NF-κB and Keap1-Nrf2 axis.
Protosappanin A protects against pathological cardiac hypertrophy by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis via activation of the Nrf2 signaling pathway.
Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.
Phytochemical nanozymes reprogram redox for balanced antimicrobial and regenerative therapy in acute and chronic diabetic wounds.
Discovery of active compounds in Danshen-Chuanxiong formula for blood-brain barrier protection: a multi-parametric study using an OGD/R-induced spheroid model.
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Uric Acid Stimulates PINK1/Parkin-Mediated Mitophagy via Nrf2/HO-1 Pathway to Protect Against Neuronal Apoptosis in Alzheimer's Disease.
Hinokitiol Protects RPE cells from Oxidative and Autophagic Dysfunction: Implications for AMD Therapy.
Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.
Placental Ferroptosis May Be Involved in Prenatal Arsenic Exposure Induced Cognitive Impairment in Offspring.
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
An SPR-based active ingredient recognition strategy for identifying PLK1-targeting withanolides as natural ferroptosis inducers.
Design, synthesis and anti-gastric cancer activity of stable Bisamide curcumin analogues.
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
Tectorigenin attenuates myocardial damage by doxorubicin-induced ferroptosis by activating the p62-Keap1-Nrf2/HO-1/GPX4 axis.
Breviscapine injection and its main component scutellarin prevents lethal enterovirus infection by inhibiting neuroinflammation and oxidative stress in newborn mice.
Dendrobium huoshanense improves atherosclerosis in high-fat-induced ApoE mice by regulating gut microbiota and serum metabolite profiles.
Inhibition of Iron Death by Lycium barbarum Polysaccharides Ameliorates Myocardial Injury in Sepsis: A Pharmacological Mechanism Study Based on the NRF2/HO-1 Pathway.
Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.
Kaempferol Plays a Neuroprotection Role by Alleviating Oxidative Stress via AKT/Nrf2/HO-1 Pathway and Inhibiting Apoptosis in Intracerebral Hemorrhage.
α-Cyperone safeguards against cerebral ischaemia‒reperfusion injury through the activation of the Nrf2 signalling pathway.
Peripheral blood mesenchymal stem cells repair oxidative damage and apoptosis in an H(2)O(2)-induced vitiligo oxidative stress in vitro model via the IL-10-mediated PI3K/AKT pathway.
Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury.
A Novel Function of Glycerol Kinase Alleviates LPS-Induced Inflammatory Responses by the p38/STAT3 Pathway and Mitigates ROS Generation in Kupffer Cells.
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
Self-assembled cyanidin-3-O-glucoside nanoparticles alleviate inflammation and ferroptosis induced by PRRSV infection.
3-hydroxyanthranilic acid analog mitigates ischemia-reperfusion injury by inhibiting cardiomyocyte ferroptosis through the activation of Nrf2/HO-1/GPX4.
Shikimic Acid Mitigates Deoxynivalenol-Induced Jejunal Barrier Injury in Mice via Activation of the Nrf-2/HO-1/NQO1 Pathway and Modulation of Gut Microbiota.
7,8-Dihydroxyflavone attenuates cisplatin-induced cardiomyocyte apoptosis and mitochondrial dysfunction via the p53/Nrf2 pathway.
Sheng Mai San Mitigates Heat Stress-Induced Myocardial Injury by Coordinated Regulation of the Keap1-Nrf2-HO-1 and Stub1-HSF1 Signaling Pathways.
Hydrogen Sulfide-Preconditioned Mesenchymal Stem Cells Attenuate Ferroptosis in Corneal Alkali Burn via the AMPK/Nrf2/HO-1 Pathway in an IL-10-Dependent Manner.
Dovitinib Ameliorates Inflammation-Related Diseases by Inhibiting Necroptosis and Ferroptosis.
Ovatodiolide triggers ferroptosis in high-grade serous ovarian cancer through HMOX1 upregulation.
Astaxanthin attenuates AFB1-induced hepatotoxicity by activating Nrf2 and inhibiting the NF-κB signaling pathway.
Early-life glyphosate exposure impairs intestinal antioxidant status and induces growth retardation in post-hatched chicks.
Entospletinib alleviates acute liver injury and acute kidney injury by inhibiting ferroptosis.
Transcription factor RUNX2 participates in astrocyte-mediated neuropathic pain via transcriptional activation of Ccl2.
Nitrate Promotes the Survival of Diabetic Skin Flaps by Enhancing Autophagy Through the AMPK Signaling Pathway.
Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway.
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.
Metal-phenolic encapsulation of carbon monoxide releasing molecule for enhanced gas therapy of periodontitis.
Construction and characteristics of an adjustable biomechanical in vitro corneal stromal model simulating keratoconus pathological features.
The Matrine Derivative MASM Alleviates LPS-Induced Depressive-Like Behavior in Mice by Modulating Hippocampal Inflammation, Oxidative Stress, and Autophagy.
Berberine inhibits high glucose-induced ferroptosis in retinal vascular endothelial cells: Mechanism and implications.
Oligodendrocyte-specific knockout of FPN1 affects CNS myelination defects and depression-like behavior in mice.
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
Hinokitiol modulates Nrf2/HO-1 signaling, autophagy, and URAT1 in hyperuricemia and oxidative stress models of renal injury.
Removal and toxic intervention of polystyrene microplastics and nanoplastics by magnetic nano-Fe(3)O(4) in spermatogonial GC-1 cells.
Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.
Protective Effects Proanthocyanidin Nanoliposome Freeze-Dried Powder on Oxidative Injury in a p31-43 Induced Celiac Disease Cell Model.
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
Harpagide Confers Protection Against Acute Lung Injury Through Multi-Omics Dissection of Immune-Microenvironmental Crosstalk and Convergent Therapeutic Mechanisms.
Targeting PARK7: Sodium 4-Phenylbutyrate shields endothelial cells from oxidative stress and GSDME-mediated Pyroptosis in acute lung injury.
Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells.
Hmox1 expression indicates distinct injury phenotypes of proximal tubule cells in sepsis-associated acute kidney injury.
Neuroprotective Effects and Mechanisms of Arecoline Against H(2)O(2)-Induced Damage in SH-SY5Y Cells.
Ginsenoside Ro Targets BCAT1/2 to Suppress Ferroptosis: A Novel Therapeutic Strategy for Ischemic Cardioprotection.
Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis.
Proanthocyanidins carbon dots inhibit PRRSV infection by activating Nrf2/ARE to regulate oxidative stress and NLRP3 inflammasome-mediated pyroptosis.
Exocarpium Citri Grandis ameliorates alcoholic liver disease by modulation of hepatic lipid metabolism and iron homeostasis.
Integrated Multiomic Analysis Reveals the Therapeutic Potential of Danhong Injection in Mitigating Radiation-Induced Heart Disease by Modulating Ferroptosis.
Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.
Design of spiro-heterocyclic substituted diaminonaphthalene Keap1-Nrf2 protein-protein interaction inhibitors as novel anti-depressant agents.
Isorhynchophylline alleviates preeclampsia via PI3K/AKT/mTOR-mediated trophoblast oxidative stress inhibition.
Fermentation of Panax ginseng C.A. Meyer extract with lactic acid bacteria exerts hepatoprotective effects via activating the NRF2 pathway.
Research on the Protective Effects and Mechanisms of Gallic Acid Against Cognitive Impairment Induced by Chronic Sleep Deprivation.
Cordycepin attenuated cyclophosphamide (CTX)-induced immunosuppression in mice via EGFR/Nrf2 antioxidant signaling pathway.
NFE2L2 protects against Sorafenib-induced Ferroptosis and cardiotoxicity by activating the HO1/ferritin pathway.
Carnosol attenuates Ang II-induced renal injury by p62-KEAP1-NRF2 signaling pathway.
ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen.
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
Astragaloside IV Alleviates Cisplatin Chemotherapy-Induced Nephrotoxicity via Modulation of Nrf2/HO-1/NF-κB Pathway and Reversal of EMT Process.
Preprotective Effects of Cardamomin From Amomum villosum Lour. on H(2)O(2) -Induced Oxidative Damage In Vitro and Cerebral Ischemic Stroke In Vivo.
Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.
Kaempferol prevents Nrf2 from ubiquitin-mediated proteolysis to mitigate both NLRP3 inflammation and oxidative stress: implications for alleviating DSS-induced colitis in mice.
Astragaloside IV: a natural shield against ochratoxin A-induced hepatotoxicity in chicks by targeting the NRF2/NLRP3 signaling pathway.
Salidroside improves bovine embryo quality by mitigating oxidative stress and regulating mitochondrial lipid metabolism.
Malic enzyme 1 reverses cardiomyocyte senescence in a nitric oxide-dependent manner.
Fufang Huangqi Jianpi Oral Liquid alleviates spleen deficiency diarrhea via modulation of the NF-κB/Nrf2 signaling pathway and apoptosis.
Gut microbiota-bile acid metabolic disorder involved in the cognitive impairments in epilepsy through HO-1 dependent ferroptosis.
CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway.
Epigallocatechin-3-Gallate Mitigates Atopic Dermatitis-Like Skin Lesions and Psychiatric Comorbidities by Reducing Oxidative Stress.
Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia-Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling-Mediated Neutrophil Extracellular Traps Formation.
Novel Role of Gut-Derived Roseburia Intestinalis in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure.
Dexmedetomidine alleviates ferroptosis caused by traumatic brain injury via the NRF2/HO-1/GPX4 pathway.
Curcumin induces ferroptosis in hepatocellular carcinoma by regulating the P62-KEAP1-NRF2-signaling pathway.
Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1.
Saponins from Dioscorea nipponinca Makino rehabilitate UVB-induced skin photoaging by inhibiting oxidative stress and apoptosis via targeting STAT3.
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Mechanism and potential targets of kaempferol alleviating photothrombotic stroke via integrating experimental validation, network pharmacology, and molecular docking.
Gastrodin Injection Relieves Hypoxic-Ischemic Brain Injury in Newborn Rats by Regulating the P62/Nrf2/HO-1 Pathway.
IL-22 attenuates MAFLD progression by modulating oxidative stress and ferroptosis.
Nrf2-ARE signaling pathway-mediated protection in rat models of intracerebral hemorrhage with different volumes.
Rescuing fertility: C-Phycocyanin prevents ovarian damage through NRF2-mediated ferroptosis pathways in polycystic ovary syndrome models.
5-Hydroxymethylfurfural Alleviates Lipopolysaccharide-Induced Depression-like Behaviors by Suppressing Hypothalamic Oxidative Stress and Regulating Neuroinflammation in Mice.
Effects of fasudil against photothrombotic stroke in genetically modified obese (ob/ob) mice.
Sotagliflozin attenuates atrial oxidative stress and the susceptibility to atrial fibrillation by activating the NRF2/HO-1 pathway.
Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors.
Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis.
Ursonic Acid Ameliorates H(2)O(2)-Induced Oxidative Damage in PC12 Cells and Prolonged the Lifespan in C. elegans by Activating MAPKs/Nrf2/HO-1 Signaling Pathway.
Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function.
Brigatinib activates inflammasomes: Implication for immune-related adverse events.
Endothelial Gsα deficiency promotes ferroptosis and exacerbates atherosclerosis in apolipoprotein E-deficient mice via the inhibition of NRF2 signaling.
Nuclear Factor Erythroid 2-Related Factor 2 Activator DDO-1039 Ameliorates Podocyte Injury in Diabetic Kidney Disease via Suppressing Oxidative Stress, Inflammation, and Ferroptosis.
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Molecular structure of VEGFA polysaccharide protein and its regulation of monocyte infiltration and oxidative stress after myocardial infarction.
Regulation of Nrf2/GPX4 Signaling Pathway by Hyperbaric Oxygen Protects Against Depressive Behavior and Cognitive Impairment in a Spinal Cord Injury Rat Model.
Hyaluronic acid-modified PtPdCo-CQ nanocatalyst with triple enzyme-like activities regulates macrophage polarization and autophagy levels for the treatment of rheumatoid arthritis.
A Keap1-recruiting BRD4 degrader offers a single-molecular polypharmacology approach for the treatment of metabolic dysfunction-associated steatohepatitis.
EPA-enriched lipid from Apostichopus japonicus byproducts mitigates UVB-induced oxidative stress and inflammation by gut-skin axis.
Acupuncture attenuates myocardial ischemia/reperfusion injury-induced ferroptosis via the Nrf2/HO-1 pathway.
Rilmenidine attenuates intracerebral hemorrhage by regulating autophagy flux and apoptosis via the HO-1/Fe(2+)/ERK pathway.
Identification of HMOX-1-Targeting Natural Compounds in Camellia nitidissima Chi for NSCLC Therapy: Integrating Bioassay and In Silico Screening Approaches.
Astragali radix - Curcumae rhizoma herb pair suppresses hepatocellular carcinoma through EGFR/AKT/mTOR pathway and induces lipid peroxidation-related ferroptosis via HIF-1α/HO-1/GPX4 axis.
Ethanol extract of Moschus attenuates glutamate-induced cytotoxicity in HT22 cells by regulating the Nrf2 and MAPK pathways.
Melatonin inhibits salivary gland epithelial cell ferroptosis via the NRF2/HO-1/GPX4 signaling pathway in primary Sjögren's syndrome.
Ferroptotic Pathway Activation in Spermatogonia: A Novel Mechanism of Busulfan-Induced Testicular Injury.
Ursolic acid suppresses ferroptosis by modulating Th17/Treg balance and gut dysbiosis in experimental autoimmune thyroiditis rats.
Exposure to Sucralose and Its Effects on Testicular Damage and Male Infertility: Insights into Oxidative Stress and Autophagy.
Lithospermic acid alleviates oxidative stress and inflammation in DSS-induced colitis through Nrf2.
Unraveling the impact of micro- and nano-sized polymethyl methacrylate on gut microbiota and liver lipid metabolism: Insights from oral exposure studies.
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata.
Corynoxeine Supplementation Ameliorates Colistin-Induced Kidney Oxidative Stress and Inflammation in Mice.
ROS-responsive dextran-benzeneboronic acid pinacol ester micelles encapsulating edaravone for the treatment and mechanism of cerebral ischemia-reperfusion injury.
Engineered Spirulina platensis for treating rheumatoid arthritis and restoring bone homeostasis.
Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes.
Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway.
Curcumin Alleviates Microglia-Mediated Neuroinflammation and Neuronal Ferroptosis Following Experimental Subarachnoid Hemorrhage by Modulating the Nrf2/HO-1 Signaling Pathway.
Metformin reverses infertility in a mouse model of endometriosis: unveiling disease pathways and implications for future clinical approaches.
The potential role of the SIRT1-Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress.
Single amino acid substitution analogs of marine antioxidant peptides with membrane permeability exert a marked protective effect against ultraviolet-B induced damage.
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease.
Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice.
SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.
The protective effect and potential mechanism of Zanthoxylum bungeanum Maxim. on atherosclerosis.
Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4.
Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.
Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2/SIRT3 signaling pathway.
Rosa roxburghii Fermentation Broths Attenuate Bleomycin-Induced Pulmonary Fibrosis by Activating the Nrf2/HO-1/NQO1 Signaling Pathway and Modulating Gut Microbiota.
Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination.
Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.
Dihydromyricetin Alleviated Acetaminophen-Induced Acute Kidney Injury via Nrf2-Dependent Anti-Oxidative and Anti-Inflammatory Effects.
Adropin-Driven Browning: Targeting M2 Macrophages to Combat PCOS.
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Electroacupuncture Attenuates Intestinal Barrier Disruption via the α7nAChR-Mediated HO-1/p38 MAPK/NF-κB Pathway in a Mouse Model of Metabolic Dysfunction-Associated Fatty Liver Disease: A Randomized, Single-Blind, Controlled Trial.
Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury.
Ditan Decoction ameliorates vascular dementia-induced cognitive dysfunction through anti-ferroptosis via the HIF1α pathway: Integrating network pharmacology and experimental validation.
Reprogramming Macrophage Phenotype Using a Reactive Oxygen Species-Responsive Liposome Delivery System for Inflammation Microenvironment Remodeling and Osteoarthritis Treatment.
ROS-responsive nanoparticles with selenomethionine for ferroptosis modulation in abdominal aortic aneurysm.
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Huachansu Injection induces ferroptosis in multiple myeloma through NRF2/HO-1 signaling pathway.
Carbon monoxide produced by HO-1 upregulation is the main factor behind the abnormal motility seen in experimental ulcerative colitis in mice.
Astaxanthin ameliorates benzalkonium chloride-induced dry eye disease through suppressing inflammation and oxidative stress via Keap1-Nrf2/HO-1 signaling pathways.
Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity.
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
Honokiol attenuates oxidative stress and vascular calcification via the upregulation of heme oxygenase-1 in chronic kidney disease.
Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction.
Fisetin alleviates oxidative stress and promotes porcine early embryonic development via activation of the NRF2-ARE signalling pathway.
Hydrogel-mediated mitochondrial reprogramming for inducing cell death: a novel approach to overcoming gemcitabine resistance in pancreatic ductal adenocarcinoma.
Novel pH-responsive lipid nanoparticles deliver UA-mediated mitophagy and ferroptosis for osteoarthritis treatment.
Polygonati kingianum polysaccharide alleviates dextran sulfate sodium-induced colitis by modulating gut microbiota and metabolic homeostasis.
CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation.
Astragaloside IV Relieves Mitochondrial Oxidative Stress Damage and Dysfunction in Diabetic Mice Endothelial Progenitor Cells by Regulating the GSK-3β/Nrf2 Axis.
Aminolevulinate/iron exposure elicited Nrf-2-mediated cytoprotection in DARS2 deficient fibroblasts with impaired energy and antioxidant metabolisms.
Liposome of Phlorizin promote the repair of carotid atherosclerosis in rats by regulating inflammation and the Nrf2 signaling pathway.
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Influence of α-Linolenic Acid on the Intestinal Barrier Integrity and Intestinal Antioxidant Status in Broilers.
Pterostilbene Reduces Cyclophosphamide-Induced Interstitial Cystitis by Facilitating Nrf2 Activation and Suppressing the NLRP3 Inflammasome Pathway.
Cerium-Organic Framework and Resveratrol Composite Hydrogel Scaffold with Dual Antioxidant Activity for Enhanced Bone Regeneration.
TRIM19 enhances the chemosensitivity of endometrial cancer by regulating the TBX2/NRF2 axis.
Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy.
Quercetin, as a Nutritional Supplement, Protects against Iron Overload-Induced Testicular Dysfunction via Inhibiting Ferroptosis.
Fibroblast growth factor 18 attenuates renal fibrosis via AMPK/NOX4 pathway in mice.
Computational design of diverse nuclear factor erythroid 2 activators with cellular antioxidative activity.
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Mechanisms of Aletris spicata (Thunb.) Franch. Extract in Asthma Therapy: Oxidative Stress, Inflammation, and Gut Microbiota.
Ferulic acid identification in brown rice using untargeted metabolomics and network analysis and its effects in mitigating AFB1-induced hepatic damage.
Daidzein alleviates CCl(4)- and BDL-induced liver fibrosis via suppressing the integrin alphaVbeta1/YAP signaling.
Overexpression of the circadian gene Bmal1 regulates the Nrf2/HO-1 oxidative stress pathway to alleviate inflammation and apoptosis in PC12 cells following cerebral ischemia-reperfusion injury.
Meloxicam Alleviates Oxidative Stress Through Nrf2/HO-1 Activation in Bovine Endometrial Epithelial Cells.
Ambient fine particulate matter induces cardiac fibrosis through triggering ferroptosis by heme degradation induced-iron overload.
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
Δ(9)-tetrahydrocannabinol induces blood-brain barrier disruption: Involving the activation of CB1R and oxidative stress.
Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2.
MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.
Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4-regulated ferroptosis.
Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis-Induced Lung Injury via Macrophage Metabolic Reprogramming.
Alleviating Effect and Potential Mechanisms of Selenium Supplementation on Chronic Liver Injury Induced by Oxidized Soybean Oil.
Empagliflozin Inhibits Neuronal Ferroptosis Induced by Oxygen-Glucose Deprivation/Reoxygenation by Activating the Nrf2/HO-1 Pathway.
Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress.
Ferroptosis Mediates the Progression of Hyperuricemic Nephropathy by Activating RAGE Signaling.
Methacrylated sericin/methacrylated hyaluronic acid composite microneedles with exosomes for diabetic wound healing.
Coriander-Derived Exosome-Like Nanovesicles Laden Hydrogel with Antioxidant Property Accelerates Wound Healing.
Lead (Pb) Induces Osteotoxicity Through the Activation of Mutually Reinforced ER Stress and ROS in MC3T3-E1 Cells.
Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction.
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer.
Dihydromyricetin attenuates intervertebral disc degeneration by inhibiting NLRP3 inflammasome activation via the Keap1/Nrf2/HO-1 pathway.
Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke.
Nanosilicates promote angiogenesis through activation of ROS-mediated WNT/β-catenin pathway.
Parishin C Attenuates Oxidative Stress and Inflammation in HT22 Hippocampal Neurons and BV2 Microglia Through Nrf2 Signaling Pathway.
DNA damage response pathway regulates Nrf2 in response to oxidative stress.
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Dopamine Alleviated Diabetic Retinal Neurodegeneration through Protecting Retinal Ganglion Cells from Ferroptosis via the Nrf2/HO‑1 Signaling Pathway.
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.
AGGF1-primed endothelial progenitor cells alleviate ischaemia-reperfusion injury in diabetic hearts.
Naringin mitigates experimental autoimmune prostatitis by modulating oxidative stress and the NLRP3 inflammasome via the PPAR-γ/NF-κB pathway.
Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/ HO-1 Pathway.
Salmonella enterica serovar typhimurium effectors spiA and spiC promote replication by modulating iron metabolism and oxidative stress.
Structural characterization and in vitro hepatoprotective activity of an acidic polysaccharide from Dendrobium nobile Lindl. flower.
Supramolecular nanoparticle loaded with bilirubin enhances cartilage protection and alleviates osteoarthritis via modulating oxidative stress and inflammatory responses.
Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways.
Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis.
Antiferroptotic properties of allicin and related organosulfur compounds-diallyl disulfide and diallyl trisulfide-from Garlic.
Ingenane diterpenoids with anti-inflammatory activity from Euphorbia antiquorum.
Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor-Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug-Resistant Tumors.
Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1.
The synergistic protective effects of paeoniflorin and β-ecdysterone against cardiac hypertrophy through suppressing oxidative stress and ferroptosis.
Effect of different dietary oil sources on the performance, egg quality and antioxidant capacity during the late laying period.
Protective Effects of α-Linolenic Acid on Liver Inflammation and Oxidative Stress Induced by Lipopolysaccharide in Broilers.
Pedunculoside inhibits cardiomyocyte inflammatory biomarkers via Nrf2/HO-1 pathway in high glucose-induced H9c2 cells and diabetic cardiomyopathy model rats.
Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.
Tanshinone IIA, a component of Salvia miltiorrhiza Bunge, attenuated sepsis-induced liver injury via the SIRT1/Sestrin2/HO-1 signaling pathway.
Multi-platform analysis revealed the substance basis and mechanism of Wei-Tong-Xin in ameliorating ENS dysfunction for dyspepsia treatment.
Extract of Nanhaia speciosa J. Compton & Schrire alleviates LPS-induced acute lung injury via the NF-κB/Nrf2/AQPs pathway.
Supplementation with carnosine, a food-derived bioactive dipeptide, alleviates dexamethasone-induced oxidative stress and bone impairment via the NRF2 signaling pathway.
HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics analysis.
Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells.
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.
Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms.
Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice.
Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.
The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
Cardiac-specific Suv39h1 knockout ameliorates high-fat diet induced diabetic cardiomyopathy via regulating Hmox1 transcription.
LC3B-regulated autophagy mitigates zinc oxide nanoparticle-induced epithelial cell dysfunction and acute lung injury.
Loss of Urat1 exacerbates APAP-induced liver injury in mice.
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota.
Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF-1α Signaling Pathway.
Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy.
Melatonin alleviates oxidative stress and inflammation of Leydig cells of Min pig through SIRT1 pathway.
Engineered Bacillus subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters the colon microbiota in a mouse model.
Retinal Protective Effect of Mono-Ethyl Fumarate in Experimental Age-Related Macular Degeneration via Anti-Oxidative and Anti-Apoptotic Alterations.
Fraxin inhibits ovariectomized-induced bone loss and osteoclastogenesis by suppressing ROS activity.
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury.
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury.
Bifidobacterium bifidum reduces oxidative stress and alters gut flora to mitigate acute liver injury caused by N-acetyl-p-aminophenol.
Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2/HMGB1/TLR4/NF-κB signaling pathway.
Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells.
Brown Algae Polysaccharides Alleviate Diquat-Induced Oxidative Stress in Piglets and IPEC-J2 Cells via Nrf2/ARE Signaling Pathway.
Analysis of ferroptosis-related genes in cerebral ischemic stroke via immune infiltration and single-cell RNA-sequencing.
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis.
PANAXADIOL SAPONIN ALLEVIATES LPS-INDUCED CARDIOMYOPATHY SIMILAR TO DEXAMETHASONE VIA IMPROVING MITOCHONDRIAL QUALITY CONTROL.
Transcranial alternating current stimulation inhibits ferroptosis and promotes functional recovery in spinal cord injury via the cGMP-PKG signalling pathway.
Luteolin Inhibits Ferroptosis of HUVEC by Regulating the Sirt1/Nrf2 Pathway.
Alpha Ketoglutaric Acid attenuates LPS Induced Inflammatory Response by Inhibiting the PKCε/MAPK/P65 Signaling Pathway and Inhibit Oxidative Stress in Kupffer Cells.
SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation.
Screening Hub Genes of Ferroptosis in Pb-Induced Acute Kidney Injury Based on GEO Database Bioinformatics and Experimental Validation.
Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis.
Nanocomposite-loaded hybrid microneedles reshape dermal microenvironment through senolytic delivery and collagen XVII-mediated barrier repair.
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
A H(2)-bioreactor for mitochondrial rehabilitation in infected bone defects regeneration.
ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling.
Docosahexaenoic acid ameliorates autistic-like behaviors by inhibiting oxidative stress and inflammatory response in neonatal maternal separation rats.
Astragalus Polysaccharide Enhances O-GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats.
Overexpression of cholesterol 24-hydroxylase CYP46A1 attenuates retinal dysfunction and ganglion cell loss via regulating the Nrf2 pathway in optic nerve crush injury.
Activation of the Nrf2/HO-1/GPX4 pathway by cGAMP Mitigates oxidative stress and ferroptosis in ischaemic stroke.
ABI3BP deficiency alleviates Ang II-induced VSMC senescence through the Nrf2 signalling pathway.
Renal tubular VMP1 protects against acute kidney injury via modulating autophagy and autophagy-independent pathway.
The phytochemical arbutin exerts potent anti-Toxoplasma effects through activation of cell-autonomous defense mechanisms while attenuating inflammation.
Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway.
Adipose-derived mesenchymal stem cell exosomes protect keratinocytes from high-glucose injury by modulating KEAP1/NRF2/HO-1 axis.
Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR-δ Signaling Pathway.
Exploring Functionally Enhanced BLP-Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance.
Mesenchymal stem cells' exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats.
Investigating Nickel-Induced Neurotoxicity: Associations with Gut Microbiota Dysbiosis and Ferroptosis.
Functional nano-nucleic acid platform promotes copper-induced gastric cancer cell death.
Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing.
Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.
Sofalcone inhibits osteoclastogenesis through Keap1/Nrf2 signaling activation and mitigates ovariectomy-induced bone loss.
Selenium improves behavioral performance in a rat model of autism spectrum disorder by mitigating oxidative stress and modulating the Sirt1/Keap1/Nrf2/HO-1 signaling pathway.
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
Butin inhibits osteoarthritis progression by modulating the Nrf2/HO-1 signaling pathway and inhibiting NF-κB signaling.
Microneedle Patch Delivering Multifunctional Melanin-like Nanoparticles for Vitiligo Remission and Repigmentation.
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
Expression and Biological Activity of Recombinant Type IV Collagen.
The Neuroprotective Effect of 4-Octyl Itaconate on Acute Period of Experimental Autoimmune Neuritis.
Synergistic Proteolysis Targeting Chimera Chemotherapy Conjugate for Potent Non-small Cell Lung Cancer Treatment.
MOTS-c attenuates mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via an Nrf2-Dependent Mechanism.
The FAK-NRF2 Axis Alleviates DOX-Induced Cardiotoxicity by Inhibiting Ferroptosis.
Cepharanthine alleviates lipopolysaccharide-induced acute lung injury through modulating macrophage polarization.
Competitive Binding of Pseudomonas aeruginosa to Kelch-Like ECH-Associated Protein 1 Inhibits Nuclear Factor Erythroid 2-Related Factor 2 Ubiquitination and Suppresses Ferroptosis in Macrophages.
Arbutin Preserves Boar Sperm During Storage at 17°C by Enhancing the Antioxidant Capacity via the NRF2/GPX4 Signalling.
Major Ozonated Autoheamotherapy Alleviates Skeletal Muscle Ischemia/Reperfusion Injury by Regulating Nrf2/HO-1 Pathway.
Ethanol extract of Sauropus spatulifolius and its active constituents attenuate LPS-induced acute lung injury via NF-κB inhibition and Nrf2 activation.
The role of FAK in renal collecting duct in the progression from acute kidney injury to chronic kidney disease.
Ergothioneine alleviates osteoporosis via the ROS-MAPK signaling Axis.
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.
NIR Driven Pd/Cerium Oxide Nano-Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy.
Butyrate protects against myocardial ischemia injury and cardiomyocyte pyroptosis by inhibiting MALT1-mediated Nrf2 ubiquitination and degradation.
T-2 Toxin-Induced Hepatotoxicity in HepG2 Cells Involves the Inflammatory and Nrf2/HO-1 Pathways.
Atractylenolide III alleviates amyloid-β-induced cognitive impairments in mice.
An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer.
Discovery of a CYP2E1 inhibitor and its therapeutic potential in severe acute pancreatitis.
Effect of the DPP4 Inhibitor Sitagliptin on Ferroptosis in Epilepsy.
Tumor microenvironments with an active type I IFN response are sensitive to inhibitors of heme degradation.
The endoplasmic reticulum stress-ferroptosis reciprocal signaling orchestrates anti-tumor effect of anlotinib in anaplastic thyroid cancer.
Isolation and identification of a new porcine astrovirus 5 demonstrated that oxidative stress enhances porcine astrovirus replication.
Luteolin attenuates trimethyltin chloride-induced hippocampal neurotoxicity through SIRT3/NRF2/HO-1 activation.
Development of Hydrogen Sulfide-Donating Silybin Derivatives with a Type-2 Diabetes Mellitus-Alleviating Effect through Improving Intestinal L-Cell Functions.
Effect of ultrasound-microbubble exposure on acute myeloid leukemia cancer cell proteome.
Dental pulp stem cells derived exosomes inhibit ferroptosis via regulating the Nrf2-keap1/GPX4 signaling pathway to ameliorate chronic kidney disease injury.
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Evidence that a Novel Chalcone Derivative, Compound 27, Acts on the Epithelium Via the PI3K/AKT/Nrf2-Keap1 Signaling Pathway, to Mitigate LPS-Induced Acute Lung Injury in Mice.
Acute hyperglycemia impedes spinal cord injury recovery via triggering excessive ferroptosis of endothelial cells.
Chlorogenic acid mitigates heat stress-induced oxidative damage in bovine mammary epithelial cells by inhibiting NF-κB-mediated NLRP3 inflammasome activation via upregulating the Nrf2 signaling pathway.
Sagittaria sagittifolia polysaccharide extract regulates Nrf2 to improve endoplasmic reticulum stress-mediated apoptosis in rat cataracts and HLEB3 cells.
Chlorogenic acid improves SPS-induced PTSD-like behaviors in rats by regulating the crosstalk between Nrf2 and NF-κB signaling pathway.
Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8(+) T cells for triple-negative breast cancer therapy.
In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics.
Magnesium isoglycyrrhizinate prevented the liver injury of acetaminophen by promoting mitochondrial biogenesis.
Smilax glabra roxb. alleviates cisplatin-induced acute kidney injury in mice by activating the Nrf2/HO-1 Signalling Pathway.
Baicalin Ameliorates L-Glutamate-Induced Hippocampal Oxidative Stress Injury and Apoptosis in Mice by Regulating Nrf2/HO-1 Signalling Pathway.
A novel histone deacetylase inhibitor protects the blood-brain barrier by regulating NF-κB and Nrf2 signaling pathways in OGD/R injury.
Inhibition of MALAT1 facilitates ROS accumulation via the Keap1/HO-1 pathway to enhance photodynamic therapy in secondary hyperparathyroidism.
Tanshinone IIA Ameliorates Myocardial Ischemia-Reperfusion Injury via Activating HDAC1-Repressed Nrf2-xCT/Gpx4/HO-1 Axis.
The Antioxidant Effect of Selenium Is Enhanced by Cortisol Through Nrf2 Pathway in Bovine Endometrial Epithelial Cells.
HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.
RAGE deficiency obstructs high uric acid-induced oxidative stress and inflammatory response.
Morinda officinalis Oligosaccharides Protect Against LPS-Induced Uterine Damage and Endometrial Inflammation in Mice and Bovine Endometrial Epithelial Cells.
Self-targeted nanosystem for enhanced chemodynamic cancer therapy.
Effects of Acrylamide on Mouse Implantation and Decidualization.
Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration.
Lactiplantibacillus plantarum -derived extracellular vesicles alleviate acute lung injury by inhibiting ferroptosis of macrophages.
Regulation of the Nrf2/HO-1 pathway in chronic obstructive pulmonary disease-induced muscle atrophy using Jinshui Liujian decoction and Bajitian pills: insights from network pharmacology and animal models.
Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity.
3,4-Dimethoxychalcone alleviates limb ischemia/reperfusion injury by TFEB-mediated autophagy enhancement and antioxidative response.
Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.
Mechanism of dracorhodin in accelerating diabetic foot ulcer healing via the Nrf2 pathway, a network pharmacology, molecular docking and experimental validation.
Krill Oil Ameliorates Liver Injury in Diabetic Mice by Activating Antioxidant Capacity and Inhibiting Ferroptosis.
Cytotoxicity and inhibitory potential of CUDC-101 in non-small cell lung cancer cells with rare EGFR L861Q mutation.
Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway.
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
The PI3K/Akt-Nrf2 Signaling Pathway and Mitophagy Synergistically Mediate Hydroxytyrosol to Alleviate Intestinal Oxidative Damage.
Benfotiamine protects MPTP-induced Parkinson's disease mouse model via activating Nrf2 signaling pathway.
Therapeutic potential of salidroside in type I diabetic erectile dysfunction: Attenuation of oxidative stress and apoptosis via the Nrf2/HO-1 pathway.
Antioxidant Carbon Dots and Ursolic Acid Co-Encapsulated Liposomes Composite Hydrogel for Alleviating Adhesion Formation and Enhancing Tendon Healing in Tendon Injury.
Dual-Stimuli-Responsive Gut Microbiota-Targeting Nitidine Chloride-CS/PT-NPs Improved Metabolic Status in NAFLD.
Artesunate-Nanoliposome-TPP, a Novel Drug Delivery System That Targets the Mitochondria, Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Stress and Inflammatory Effects.
The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway.
Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice.
5-Methoxytryptophan Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating Nrf2-Mediated Mitophagy.
Diosgenin derivative ML5 attenuates MPTP-induced neuronal impairment via regulating AMPK/PGC-1α-mediated mitochondrial biogenesis and fusion/fission.
NCAPD3-mediated ferroptosis of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells.
Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells.
β-cryptoxanthin suppresses oxidative stress via activation of the Nrf2/HO-1 signaling pathway in diabetic kidney disease.
Brozopine ameliorates cognitive impairment via upregulating Nrf2, antioxidation and anti-inflammation activities.
Li-Hong Tang alleviates dextran sodium sulfate-induced colitis by regulating NRF2/HO-1 signaling pathway and gut microbiota.
LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway.
FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.
A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4.
Neuregulin-1, a member of the epidermal growth factor family, mitigates STING-mediated pyroptosis and necroptosis in ischaemic flaps.
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Inhibition effect of copper-bearing metals on arterial neointimal hyperplasia via the AKT/Nrf2/ARE pathway in vitro and in vivo.
Antioxidant and anti-inflammatory injectable hydrogel microspheres for in situ treatment of tendinopathy.
Myo-inositol improves developmental competence and reduces oxidative stress in porcine parthenogenetic embryos.
Low expression of selenoprotein S induces oxidative damage in cartilages.
Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.
NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.
Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway.
Prediction and verification of targets for α-hederin/oxaliplatin dual-loaded rHDL modified liposomes: Reversing effector T-cells dysfunction and improving anti-COAD efficiency in vitro and in vivo.
Network Analysis of Gut Microbial Communities Reveals Key Reason for Quercetin Protects against Colitis.
Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis.
A Lysosome-Targeting hNEU1 Inhibitor Treats Myocardial Infarction: A Potential Therapeutic Breakthrough.
MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
Protective role of seleno-amino acid against IBD via ferroptosis inhibition in enteral nutrition therapy.
Salidroside alleviates simulated microgravity-induced bone loss by activating the Nrf2/HO-1 pathway.
MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis.
NBQX mediates ventricular fibrillation susceptibility in rat models of anxiety via the Nrf2/HO-1 pathway.
LFHP-1c improves cognitive function after TBI in mice by reducing oxidative stress through the PGAM5-NRF2-KEAP1 ternary complex.
Time-restricted feeding relieves high temperature-induced impairment on meat quality by activating the Nrf2/HO-1 pathway, modification of muscle fiber composition, and enriching the polyunsaturated fatty acids in pigs.
Occlusal disharmony promotes anxiety-like behaviours by suppressing Sirt1.
Ocotillol Derivatives Mitigate Retinal Ischemia-Reperfusion Injury by Regulating the Keap1/Nrf2/ARE Signaling Pathway.
Phosphatase LHPP confers prostate cancer ferroptosis activation by modulating the AKT-SKP2-ACSL4 pathway.
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis.
Apo-12'-capsorubinal exhibits anti-inflammatory effects and activates nuclear factor erythroid 2-related factor 2 in RAW264.7 macrophages.
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway.
Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H(2)O(2)-Induced Neuronal PC12 Cells and Prolongs the Lifespan of Caenorhabditis elegans.
Targeting Mitochondrial Oxidative Stress to Protect Against Preterm Birth and Fetal Brain Injury via Nrf2 Induction.
Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway.
Mangiferin activates the nuclear factor erythroid 2-related factor pathway to protect SOD1-G93A induced NSC-34 motor neurons from oxidative stress and apoptosis.
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.
Bombesin protects myocardium against ischemia/reperfusion injury via activation of the Keap1-Nrf2-HO-1 signaling pathway.
Artemether ameliorates acetaminophen-induced liver injury through Nrf2 pathway.
p-Hydroxy benzaldehyde, a phenolic compound from Nostoc commune, ameliorates DSS-induced colitis against oxidative stress via the Nrf2/HO-1/NQO-1/NF-κB/AP-1 pathway.
Gui Qi Zhuang Jin Decoction ameliorates mitochondrial dysfunction in sarcopenia mice via AMPK/PGC-1α/Nrf2 axis revealed by a metabolomics approach.
Phenylpropanoid-rich maize root extract serves as a natural antidepressant.
Neutrophil-Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy.
Human umbilical cord mesenchymal stem cells-derived exosomes attenuate burn-induced acute lung injury via inhibiting ferroptosis.
Targeting Bacteria-Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects.
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Dietary ferulic acid supplementation enhances antioxidant capacity and alleviates hepatocyte pyroptosis in diquat challenged piglets.
Sodium Hydrosulfide Protects Rats from Hypobaric-Hypoxia-Induced Acute Lung Injury.
Acupoint Autohemotherapy Alleviates Airway Inflammation in Asthmatic Rats via Upregulating Expression of Hemeoxygenase-1.
Qifu-yin activates the Keap1/Nrf2/ARE signaling and ameliorates synaptic injury and oxidative stress in APP/PS1 mice.
Essential oil from Chimonanthus nitens Oliv. Leaves ameliorate inflammation and oxidative stress in LPS-induced ALI through NF-κB and Nrf2 signaling pathways.
Dioscin exerts nephroprotective effects by attenuating oxidative stress and necroptosis-induced inflammation.
Ellagic Acid Reduces Cadmium Exposure-Induced Apoptosis in HT22 Cells via Inhibiting Oxidative Stress and Mitochondrial Dysfunction and Activating Nrf2/HO-1 Pathway.
Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling.
A novel role for WZ3146 in the inhibition of cell proliferation via ERK and AKT pathway in the rare EGFR G719X mutant cells.
Role of iron homeostasis in the mutagenicity of disinfection by-products in mammalian cells.
Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study.
Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments.
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1.
A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant.
Ferulic Acid Inhibits Arsenic-Induced Colon Injury by Improving Intestinal Barrier Function.
Ferulic Acid Protects Human Lens Epithelial Cells Against UVA-Induced Oxidative Damage by Downregulating the DNA Demethylation of the Keap1 Promoter.
Mechanical Stress-Oxidative Stress Axis: Biological Basis in the Vaginal Wall and Pelvic Floor Muscles of Rats with Simulated Birth Injury.
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Polysaccharide of Dicliptera chinensis (L.) Juss. alleviated cholestatic liver disease by modulating the FXR pathway.
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
Vitamin U alleviates AFB(1)-induced hepatotoxicity in pregnant and lactating mice by regulating the Nrf2/Hmox1 pathway.
Lutein protects senescent ciliary muscle against oxidative stress through the Keap1/Nrf2/ARE pathway.
S. glabra exerts anti-lung cancer effects by inducing ferroptosis and anticancer immunity.
Human placental mesenchymal stromal cells alleviate intestinal oxidative damage in mice with graft-versus-host disease via CD73/adenosine/PI3K/Akt/GSK-3β axis.
Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradation.
Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma.
Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage.
Microplastics Exposure Aggravates Synovitis and Pyroptosis in SLE by Activating NF-κB and NRF2/KEAP1 Signaling.
High-throughput screening-based design of multifunctional natural polyphenol nano-vesicles to accelerate diabetic wound healing.
Mesenchymal stromal cells deliver H(2)S-enhanced Nrf2 via extracellular vesicles to mediate mitochondrial homeostasis for repairing hypoxia-ischemia brain damage.
Proteomic and lipidomic analysis of the mechanism underlying astragaloside IV in mitigating ferroptosis through hypoxia-inducible factor 1α/heme oxygenase 1 pathway in renal tubular epithelial cells in diabetic kidney disease.
A new strategy for Astragaloside IV in the treatment of diabetic kidney disease: Analyzing the regulation of ferroptosis and mitochondrial function of renal tubular epithelial cells.
osa-miR168a, a Plant miRNA That Survives the Process of In Vivo Food Digestion, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice by Oral Administration.
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization.
Identification of ROS and KEAP1-related genes and verified targets of α-hederin induce cell death for CRC.
Sodium butyrate alleviates experimental autoimmune prostatitis by inhibiting oxidative stress and NLRP3 inflammasome activation via the Nrf2/HO-1 pathway.
BDNF mimetics recover palmitic acid-induced injury in cardiomyocytes by ameliorating Akt-dependent mitochondrial impairments.
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.
Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing.
Mastoparan M promotes functional recovery in stroke mice by activating autophagy and inhibiting ferroptosis.
Isoliquiritigenin reduces experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway.
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Essential oil from Citrus depressa peel exhibits antimicrobial, antioxidant and cancer chemopreventive effects.
Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens.
Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway.
Blocking of FGFR4 signaling by F30 inhibits hepatocellular carcinoma cell proliferation through HMOX1-dependent ferroptosis pathway.
Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy.
Molecular, biological characterization and drug sensitivity of chidamide-resistant MCF7 cells.
Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis.
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
BDTX-189, a novel tyrosine kinase inhibitor, inhibits cell activity via ERK and AKT pathways in the EGFR C797S triple mutant cells.
Paeoniflorin attenuates particulate matter-induced acute lung injury by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis through activation of the Nrf2 signaling pathway.
Chondrocyte-targeted exosome-mediated delivery of Nrf2 alleviates cartilaginous endplate degeneration by modulating mitochondrial fission.
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury.
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.
Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.
Naringin attenuates Actinobacillus pleuropneumoniae-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway.
Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways.
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway.
Effects of Pemafibrate on Reducing Oxidative Stress and Augmenting Angiogenesis in Ischemic Limb Tissue.
Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress.
Edaravone dexborneol protects against cerebral ischemia/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2/HO-1/GPX4 signaling.
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 pathway to prevent α-synuclein-induced ferroptosis in Parkinson's disease.
Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine.
Glycyrrhizin regulates antioxidation through Nrf2 signaling pathway in rat temporomandibular joint osteoarthritis.
Quercetin alleviates the toxicity of difenoconazole to the respiratory system of carp by reducing ROS accumulation and maintaining mitochondrial dynamic balance.
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation.
Dapagliflozin Alleviates Diabetic Kidney Disease via Hypoxia Inducible Factor 1α/Heme Oxygenase 1-Mediated Ferroptosis.
MFSD7c functions as a transporter of choline at the blood-brain barrier.
Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.
Electroacupuncture Attenuates Ventilator-Induced Lung Injury by Modulating the Nrf2/HO-1 Pathway.
Rhizoma Paridis saponins attenuate Gram-negative bacteria-induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways.
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
Nrf-2/ROS/NF-κB pathway is modulated by cynarin in human mesenchymal stem cells in vitro from ankylosing spondylitis.
Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets.
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.
Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity.
VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.
Role of Nrf2/HO-1 pathway on inhibiting activation of ChTLR15/ChNLRP3 inflammatory pathway stimulated by E. tenella sporozoites.
Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice.
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway.
Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2.
Bi(2)S(3)/Ti(3)C(2)-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors.
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation.
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment.
From inflammation to pyroptosis: Understanding the consequences of cadmium exposure in chicken liver cells.
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo.
Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.
Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis.
A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway.
Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin-induced liver injury.
Arecoline induces neurotoxicity in HT22 cells via the promotion of endoplasmic reticulum stress and downregulation of the Nrf2/HO-1 pathway.
Inhibitor of apoptosis stimulating protein of p53 protects against MPP(+)-induced neurotoxicity of dopaminergic neurons.
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Bicyclol Alleviates Streptozotocin-induced Diabetic Cardiomyopathy By Inhibiting Chronic Inflammation And Oxidative Stress.
The TF/Nrf2/GSTP1 pathway is involved in stress-induced hepatocellular injury through ferroptosis.
Cu(2)WS(4)-PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno-Radiotherapy by Inducing Ferroptosis.
New sesquiterpenoids with neuroprotective effects in vitro and in vivo from the Picrasma chinensis.
Dihydromyricetin regulates KEAP1-Nrf2 pathways to enhance the survival of ischemic flap.
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases.
Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease.
Mechanistic studies on the alleviation of ANIT-induced cholestatic liver injury by Polygala fallax Hemsl. polysaccharides.
Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators.
Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis.
Fucoxanthin alleviates lipopolysaccharide-induced intestinal barrier injury in mice.
The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo.
Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice.
Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload.
X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway.
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling.
Cytoprotective Role of Autophagy in CDIP1 Expression-Induced Apoptosis in MCF-7 Breast Cancer Cells.
Octanoic acid mitigates busulfan-induced blood-testis barrier damage by alleviating oxidative stress and autophagy.
Hsa_circ_0096157 silencing suppresses autophagy and reduces cisplatin resistance in non-small cell lung cancer by weakening the Nrf2/ARE signaling pathway.
HMOX1 regulates ferroptosis via mic14 and its impact on chemotherapy resistance in small-cell lung cancer.
HO-1 upregulation promotes mitophagy-dependent ferroptosis in PM2.5-exposed hippocampal neurons.
Conditional Knockout of IL-1R1 in Endothelial Cells Attenuates Seizures and Neurodegeneration via Inhibiting Neuroinflammation Mediated by Nrf2/HO-1/NLRP3 Signaling in Status Epilepticus Model.
Heme oxygenase activates calcium release from the endoplasmic reticulum of bovine mammary epithelial cells to promote TFEB entry into the nucleus to reduce the intracellular load of Mycoplasma bovis.
PEDF and 34-mer peptide inhibit cardiac microvascular endothelial cell ferroptosis via Nrf2/HO-1 signalling in myocardial ischemia-reperfusion injury.
Mechanism and functional verification of genes by virulence factors of P. gingivalis in ferroptosis.
Emodin alleviates intestinal ischemia-reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation.
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
SUMOylation modification of FTO facilitates oxidative damage response of arsenic by IGF2BP3 in an m6A-dependent manner.
Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway.
Baicalin promotes the sensitivity of NSCLC to cisplatin by regulating ferritinophagy and macrophage immunity through the KEAP1-NRF2/HO-1 pathway.
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
Protective effects of patchouli alcohol against DSS-induced ulcerative colitis.
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.
Bacillus cereus CwpFM induces colonic tissue damage and inflammatory responses through oxidative stress and the NLRP3/NF-κB pathway.
Protective effects of L-theanine and dihydromyricetin on reproductive function in male mice under heat stress.
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling.
KAN0438757, a novel PFKFB3 inhibitor, prevent the progression of severe acute pancreatitis via the Nrf2/HO-1 pathway in infiltrated macrophage.
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats.
Near-infrared-responsive GE11-CuS@Gal nanoparticles as an intelligent drug release system for targeting therapy against oral squamous cell carcinoma.
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Targeting Keap1 with Inulae Herba activated the Nrf2 receptor to alleviate LPS-mediated acute lung injury.
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Bardoxolone methyl breaks the vicious cycle between M1 macrophages and senescent nucleus pulposus cells through the Nrf2/STING/NF-κB pathway.
α-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice.
Perfluorocarbon Nanoparticles Incorporating Ginkgolide B: Artificial O(2) Carriers with Antioxidant Activity and Antithrombotic Effect.
Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway.
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Jujuboside B alleviates acetaminophen-induced hepatotoxicity in mice by regulating Nrf2-STING signaling pathway.
4-octyl itaconate ameliorates ventilator-induced lung injury.
Fibroblast growth factor receptor-4 mediates activation of Nuclear Factor Erythroid 2-Related Factor-2 in gastric tumorigenesis.
Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma.
Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning.
Silver nitroprusside as an efficient chemodynamic therapeutic agent and a peroxynitrite nanogenerator for targeted cancer therapies.
Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K/AKT pathway.
Dimerized sesquiterpenoid [4 + 2] adducts with ferroptosis-promoting activity from Inula britannica Linn.
Fluorene-9-bisphenol exposure damages the testis in mice through a novel mechanism of ferroptosis.
Ferrostatin-1 Blunts Right Ventricular Hypertrophy and Dysfunction in Pulmonary Arterial Hypertension by Suppressing the HMOX1/GSH Signaling.
Visual identification of three kinds of human decidual tissues from elective termination of pregnancy.
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling.
Synergistic suppression of ovarian cancer by combining NRF2 and GPX4 inhibitors: in vitro and in vivo evidence.
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.
Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation.
Fluorescent gold nanoclusters possess multiple actions against atherosclerosis.
Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling.
TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2.
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway.
Nanoparticles transfected with plasmid-encoded lncRNA-OIP5-AS1 inhibit renal ischemia-reperfusion injury in mice via the miR-410-3p/Nrf2 axis.
Sarmentosin alleviates doxorubicin-induced cardiotoxicity and ferroptosis via the p62-Keap1-Nrf2 pathway.
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
Electroacupuncture pretreatment maintains mitochondrial quality control via HO-1/MIC60 signaling pathway to alleviate endotoxin-induced acute lung injury.
Protective Effect of Acteoside against Hydrogen Peroxide-Induced Oxidative Damage in Human Corneal Epithelial Cells.
Puerarin alleviates symptoms of preeclampsia through the repression of trophoblast ferroptosis via the CREB/HO-1 pathway.
Baliosperoid A attenuates lipopolysaccharide-induced acute lung injury by targeting SHP2 to inhibit inflammation and oxidative stress.
Design, green synthesis, and anti-glutamate damage screening of chalcone derivatives with spiro-heterocyclic structures as potential anti-ischemic brain and eye damage agents.
Discovery of novel 5-phenyl-1H-pyrrole-2-carboxylic acids as Keap1-Nrf2 inhibitors for acute lung injury treatment.
M2 macrophage derived HMOX1 defines chronic rhinosinusitis with nasal polyps.
Dang-Gui-Bu-Xue decoction against diabetic nephropathy via modulating the carbonyl compounds metabolic profile and AGEs/RAGE pathway.
Role of hypoxia-inducible-factor-1α (HIF-1α) in ferroptosis of adipose tissue during ketosis.
Dietary Bacillus subtilis benefits meat quality by regulating the muscle fiber type and antioxidant capacity of broilers.
The Novel Elemene Derivative, OMe-Ph-Elemene, Attenuates Oxidative Phosphorylation and Facilitates Apoptosis by Inducing Intracellular Reactive Oxygen Species.
Gypenoside A-loaded mPEG-PLGA nanoparticles ameliorate high-glucose-induced retinal microvasculopathy by inhibiting ferroptosis.
Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K/AKT signaling pathway.
Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1α/HO-1 pathway.
Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects.
Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO-1 pathway.
Isolicoflavonol ameliorates acute liver injury via inhibiting NLRP3 inflammasome activation through boosting Nrf2 signaling in vitro and in vivo.
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro.
miR-328-3p suppresses hepatocellular carcinoma progression by regulating HMOX1 expression.
Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1.
4-Octyl itaconate inhibits vascular calcification partially via modulation of HMOX-1 signaling.
Carbon dots encapsulated zeolitic imidazolate framework-8 as an enhanced multi-antioxidant for efficient cytoprotection to HK-2 cells.
Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing Aβ levels.
Discovery of the synergy between sulindac and NO expands the application of NSAIDs in cardiac complications.
Melatonin attenuates hepatic oxidative stress by regulating the P62/LC3 autophagy pathway in PCOS.
Activating MC4R Promotes Functional Recovery by Repressing Oxidative Stress-Mediated AIM2 Activation Post-spinal Cord Injury.
HO-1-induced autophagy establishes a HO-1-p62-Nrf2 positive feedback loop to reduce gut permeability in cholestatic liver disease.
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.
Curcumin inhibits PAT-induced renal ferroptosis via the p62/Keap1/Nrf2 signalling pathway.
Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis.
Ezetimibe ketone protects against renal ischemia-reperfusion injury and attenuates oxidative stress via activation of the Nrf2/HO-1 signaling pathway.
CRHR1 antagonist alleviated depression-like behavior by downregulating p62 in a rat model of post-stroke depression.
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Casticin induces ferroptosis in human osteosarcoma cells through Fe(2+) overload and ROS production mediated by HMOX1 and LC3-NCOA4.
Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways.
Changes in PI3K/AKT and NRF2/HO-1 signaling expression and intestinal microbiota in bleomycin-induced pulmonary fibrosis.
Polystyrene microplastics exposure reduces meat quality and disturbs skeletal muscle angiogenesis via thrombospondin 1.
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.
miR-200a-3p-enriched MSC-derived extracellular vesicles reverse erectile function in diabetic rats by targeting Keap1.
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Potential mechanism prediction of indole-3-propionic acid against diminished ovarian reserve via network pharmacology, molecular docking and experimental verification.
Combining Multiple Omics with Molecular Dynamics Reveals SCP2-Mediated Cytotoxicity Effects of Aflatoxin B1 in SW480 Cells.
Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy.
Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity.
The involvement of the Stat1/Nrf2 pathway in exacerbating Crizotinib-induced liver injury: implications for ferroptosis.
Inhaled tea polyphenol-loaded nanoparticles coated with platelet membranes largely attenuate asthmatic inflammation.
Mesenchymal stem cell-derived extracellular vesicles mitigate neuronal damage from intracerebral hemorrhage by modulating ferroptosis.
EGCG-NPs inhibition HO-1-mediated reprogram iron metabolism against ferroptosis after subarachnoid hemorrhage.
SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
Exosomes derived from bone marrow mesenchymal stem cells alleviate biliary ischemia reperfusion injury in fatty liver transplantation by inhibiting ferroptosis.
Icariin alleviates renal inflammation and tubulointerstitial fibrosis via Nrf2-mediated attenuation of mitochondrial damage.
SESN2-Mediated AKT/GSK-3β/NRF2 Activation to Ameliorate Adriamycin Cardiotoxicity in High-Fat Diet-Induced Obese Mice.
CD44-targeted melanin-based nanoplatform for alleviation of ischemia/reperfusion-induced acute kidney injury.
Roles of heat shock protein A12A in the development of diabetic cardiomyopathy.
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction.
Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis.
H(2)S-Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation.
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
Guben Qingfei decoction attenuates LPS-induced acute lung injury by modulating the TLR4/NF-κB and Keap1/Nrf2 signaling pathways.
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.
The role of FPR2-mediated ferroptosis in formyl peptide-induced acute lung injury against endothelial barrier damage and protective effect of the mitochondria-derived peptide MOTS-c.
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Quercetin Ameliorates Diabetic Kidney Injury by Inhibiting Ferroptosis via Activating Nrf2/HO-1 Signaling Pathway.
Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways.
Exploring the role of Hmox1 in ferroptosis and immune infiltration during renal ischemia-reperfusion injury.
Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes.
Detection of Ferroptosis by Immunohistochemistry and Immunofluorescence.
Fisetin Ameliorates Diabetic Nephropathy-Induced Podocyte Injury by Modulating Nrf2/HO-1/GPX4 Signaling Pathway.
Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression.
Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice.
Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis.
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
Evaluation of arsenic metabolism and tight junction injury after exposure to arsenite and monomethylarsonous acid using a rat in vitro blood-Brain barrier model.
Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis.
Resolvin D1 Attenuates Inflammation and Pelvic Pain Associated with EAP by Inhibiting Oxidative Stress and NLRP3 Inflammasome Activation via the Nrf2/HO-1 Pathway.
Mechanism of Wuzhuyu decoction on alcohol-induced gastric ulcers using integrated network analysis and metabolomics.
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.
Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis.
Resolvin D1/N-formyl peptide receptor 2 ameliorates paclitaxel-induced neuropathic pain through the activation of IL-10/Nrf2/HO-1 pathway in mice.
Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway.
Fangchinoline alleviates cognitive impairments through enhancing autophagy and mitigating oxidative stress in Alzheimer's disease models.
Phellodendronoside A Exerts Anticancer Effects Depending on Inducing Apoptosis Through ROS/Nrf2/Notch Pathway and Modulating Metabolite Profiles in Hepatocellular Carcinoma.
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway.
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.
Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress.
Effect of renal denervation on cardiac remodelling and function in rats with chronic intermittent hypoxia.
Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.
Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
Activation of Nrf2 inhibits ferroptosis and protects against oxaliplatin-induced ototoxicity.
Ozone pretreatment alleviates ischemiareperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis.
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.
Artesunate alleviates intestinal ischemia/reperfusion induced acute lung injury via up-regulating AKT and HO-1 signal pathway in mice.
Small extracellular vesicles from HO-1-modified bone marrow-derived mesenchymal stem cells attenuate ischemia-reperfusion injury after steatotic liver transplantation by suppressing ferroptosis via miR-214-3p.
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer.
Exploring anti-acute kidney injury mechanism of Dahuang-Gancao decoction by network pharmacology and experimental validation.
Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis.
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
LYVE-1(+) macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.
Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation.
Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis.
Graphene oxide had adverse effects on sperm motility and morphology through oxidative stress.
Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia-reperfusion injury model of mice.
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11.
Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase.
Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways.
Effects of dietary resveratrol supplementation in cattle on the anti-oxidative capacity and meat quality of beef steaks under high‑oxygen packaging.
MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis.
Puerarin protects against acetaminophen-induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway.
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity.
Rosmarinic acid treatment protects against lethal H1N1 virus-mediated inflammation and lung injury by promoting activation of the h-PGDS-PGD(2)-HO-1 signal axis.
Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis.
A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy.
Dankasterone A induces prostate cancer cell death by inducing oxidative stress.
Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia/reperfusion injury through PI3K/Akt-mediated Nrf2 signaling pathways.
Injectable microenvironment-responsive hydrogels with redox-activatable supramolecular prodrugs mediate ferroptosis-immunotherapy for postoperative tumor treatment.
Taxifolin protects against doxorubicin-induced cardiotoxicity and ferroptosis by adjusting microRNA-200a-mediated Nrf2 signaling pathway.
The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress.
Heme Oxygenase-1-Modified BMMSCs Activate AMPK-Nrf2-FTH1 to Reduce Severe Steatotic Liver Ischemia-Reperfusion Injury.
Fullerol rescues the light-induced retinal damage by modulating Müller glia cell fate.
T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1.
Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation.
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway.
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage.
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
CDDO-Me ameliorates podocyte injury through anti-oxidative stress and regulation of actin cytoskeleton in adriamycin nephropathy.
Koumine ameliorates neuroinflammation by regulating microglia polarization via activation of Nrf2/HO-1 pathway.
Treatment of human cardiac fibroblasts with the protein arginine deiminase inhibitor BB-Cl-amidine activates the Nrf2/HO-1 signaling pathway.
The eNOS-induced leonurine's new role in improving the survival of random skin flap.
A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages.
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro.
Wogonin inhibits oxidative stress and vascular calcification via modulation of heme oxygenase-1.
Quercetin Attenuates the Combined Effects of Zearalenone and Lipopolysaccharide on IPEC-J2 Cell Injury through Activating the Nrf2 Signaling Pathway.
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Chlorogenic Acid Alleviated AFB1-Induced Hepatotoxicity by Regulating Mitochondrial Function, Activating Nrf2/HO-1, and Inhibiting Noncanonical NF-κB Signaling Pathway.
Spermidine suppresses oxidative stress and ferroptosis by Nrf2/HO-1/GPX4 and Akt/FHC/ACSL4 pathway to alleviate ovarian damage.
MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis.
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration.
Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice.
Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis.
Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway.
Cardamonin targets KEAP1/NRF2 signaling for protection against atherosclerosis.
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.
ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer.
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization.
The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity.
Liquiritin alleviates alpha-naphthylisothiocyanate-induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway.
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Ro25-6981 alleviates neuronal damage and improves cognitive deficits by attenuating oxidative stress via the Nrf2/ARE pathway in ischemia/reperfusion rats.
Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.
LncRNA UCA1 promoted cisplatin resistance in lung adenocarcinoma with HO1 targets NRF2/HO1 pathway.
Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.
Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss.
FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.
Stimulation of Nuclear Factor (Erythroid-Derived 2)-like 2 Signaling by Nucleus Targeted Irradiation with Proton Microbeam.
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.
Uridine Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Ferroptosis of Macrophage.
Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on Ethanol-Induced Damage to HepG2 Cells and Animal Models.
Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway.
Reduced SUMOylation of Nrf2 signaling contributes to its inhibition induced by amyloid-β.
Elevation of HO-1 expression protects the intestinal mucosal barrier in severe acute pancreatitis via inhibition of the MLCK/p-MLC signaling pathway.
1,2,4,5-Tetrazine-tethered probes for fluorogenically imaging superoxide in live cells with ultrahigh specificity.
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Effects and mechanisms of Xiaochaihu Tang against liver fibrosis: An integration of network pharmacology, molecular docking and experimental validation.
Tingli Dazao Decoction pretreatment ameliorates mitochondrial damage induced by oxidative stress in cardiomyocytes.
Buyang Huanwu decoction alleviates oxidative injury of cerebral ischemia-reperfusion through PKCε/Nrf2 signaling pathway.
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Remote preconditioning combined with nebulized budesonide alleviate lipopolysaccharide induced acute lung injury via regulating HO-1 and NF-κB in rats.
Farnesol Exerts Protective Effects against Chronic Sleep Deprivation-Induced Cognitive Impairment via Activation SIRT1/Nrf2 Pathway in the Hippocampi of Adult Mice.
Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP(+)-Induced SH-SY5Y Cells.
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
Effect of PPARγ on oxidative stress in diabetes-related dry eye.
BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion.
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.
Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling.
Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway.
PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis.
Ferulic Acid Alleviates Hepatic Lipid Accumulation and Inflammation by Improving Proximal and Distal Intestinal Barriers in NAFLD Mice.
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals.
Antioxidant Peptides from Monkfish Swim Bladders: Ameliorating NAFLD In Vitro by Suppressing Lipid Accumulation and Oxidative Stress via Regulating AMPK/Nrf2 Pathway.
Long-term effect of PBDE-99 prenatal exposure on spermatogenic injuries via the dysregulation of autophagy.
Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression.
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
Resveratrol Promotes Gluconeogenesis by Inhibiting SESN2-mTORC2-AKT Pathway in Calf Hepatocytes.
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Glycyrrhizin protects against particulate matter-induced lung injury via regulation of endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis through Nrf2/HO-1/NQO1 signaling pathway.
Metformin Ameliorates 2.856 GHz Microwave- Radiation-Induced Reproductive Impairments in Male Rats via Inhibition of Oxidative Stress and Apoptosis.
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice.
The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing.
Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1.
Tripterygium glycosides reverse chemotherapy resistance in ovarian cancer by targeting the NRF2/GPX4 signal axis to induce ferroptosis of drug-resistant human epithelial ovarian cancer cells.
Andrographolide induced ferroptosis in multiple myeloma cells by regulating the P38/Nrf2/HO-1 pathway.
Antibiotics administration alleviates the high fat diet-induced obesity through altering the lipid metabolism in young mice.
HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe(2+) Production.
iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation.
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Novel function of Roxadustat (FG-4592) as an anti-shock drug in sepsis by regulating mitochondrial oxidative stress and energy metabolism.
Pine pollen extract alleviates ethanol-induced oxidative stress and apoptosis in HepG2 cells via MAPK signaling.
Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice.
N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
Paricalcitol Ameliorates Acute Kidney Injury in Mice by Suppressing Oxidative Stress and Inflammation via Nrf2/HO-1 Signaling.
Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo.
Protective effects of Lycium barbarum L. berry extracts against oxidative stress-induced damage of the retina of aging mouse and ARPE-19 cells.
Protein kinase D1 promotes the survival of random-pattern skin flaps in rats.
Inhibition of cGAS ameliorates acute lung injury triggered by zinc oxide nanoparticles.
Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway.
Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling.
Organic extracts in PM2.5 are the major triggers to induce ferroptosis in SH-SY5Y cells.
Inhibition of YAP by lenvatinib in endothelial cells increases blood pressure through ferroptosis.
Disruption of the lung-gut-brain axis is responsible for cortex damage induced by pulmonary exposure to zinc oxide nanoparticles.
Dual Antioxidant DH-217 Mitigated Cerebral Ischemia-Reperfusion Injury by Targeting IKKβ/Nrf2/HO-1 Signal Axis.
Berberine promotes the viability of random skin flaps via the PI3K/Akt/eNOS signaling pathway.
Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression.
Chemical constituents from the stems and leaves of Amomum villosum Lour. and their anti-inflammatory and antioxidant activities.
α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson's disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway.
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.
Active Nrf2 signaling flexibly regulates HO-1 and NQO-1 in hypoxic Gansu Zokor (Eospalax cansus).
Non-Lethal Concentrations of CdCl(2) Cause Marked Alternations in Cellular Stress Responses within Exposed Sertoli Cell Line.
Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function.
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke.
Lactobacillus johnsonii L531 Ameliorates Salmonella enterica Serovar Typhimurium Diarrhea by Modulating Iron Homeostasis and Oxidative Stress via the IRP2 Pathway.
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.
Otoprotective Effects of Fucoidan Reduce Cisplatin-Induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells.
A novel combination therapy with Cabozantinib and Honokiol effectively inhibits c-Met-Nrf2-induced renal tumor growth through increased oxidative stress.
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.
Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways.
PM(2.5) exposure increases dry eye disease risks through corneal epithelial inflammation and mitochondrial dysfunctions.
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway.
Park7 protects retinal ganglion cells and promotes functional preservation after optic nerve crush via regulation of the Nrf2 signaling pathway.
Xanthohumol attenuates renal ischemia/reperfusion injury by inhibiting ferroptosis.
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis via activation of PPARγ signaling in mice.
Protective effect of ethyl ferulate against hypoxic injury in retinal cells and retinal neovascularization in an oxygen-induced retinopathy model.
7,8,3'-Trihydroxyflavone prevents doxorubicin-induced cardiotoxicity and mitochondrial dysfunction via activating Akt signaling pathway in H9c2 cells.
Probiotic-fermented Qushi decoction alleviates reserpine-induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis.
The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.
Dexmedetomidine alleviates ferroptosis following hepatic ischemia-reperfusion injury by upregulating Nrf2/GPx4-dependent antioxidant responses.
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
Dietary pyrroloquinoline quinone improvement of the antioxidant capacity of laying hens and eggs are linked to the alteration of Nrf2/HO-1 pathway and gut microbiota.
Hepatotoxicity of the Pesticide Avermectin Exposure to Freshwater-Farmed Carp: Evidence from In Vivo and In Vitro Research.
Endometrial stromal cell autophagy-dependent ferroptosis caused by iron overload in ovarian endometriosis is inhibited by the ATF4-xCT pathway.
Adoptive transfer of immature dendritic cells with high HO-1 expression delays the onset of T1DM in NOD mice.
Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms.
Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes.
Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways.
5-Methoxytryptophan ameliorates endotoxin-induced acute lung injury in vivo and in vitro by inhibiting NLRP3 inflammasome-mediated pyroptosis through the Nrf2/HO-1 signaling pathway.
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease.
ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis.
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma.
CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway.
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Retinoic acid protects against lipopolysaccharide-induced ferroptotic liver injury and iron disorders by regulating Nrf2/HO-1 and RARβ signaling.
The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway.
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis.
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Metalloporphyrins Reduce Proteinuria in Podocyte Immune Injury: The Role of Metal and Porphyrin Moieties.
Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota.
Exosomes secreted by mesenchymal stem cells delay brain aging by upregulating SIRT1 expression.
Nrf2 protects against methamphetamine-induced nephrotoxicity by mitigating oxidative stress and autophagy in mice.
Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity.
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Mechanisms regarding respiratory toxicity triggered by accumulation of ROS in carp exposed to difenoconazole.
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway.
Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs.
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways.
Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress.
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Blue LED light induces cytotoxicity via ROS production and mitochondrial damage in bovine subcutaneous preadipocytes.
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
PM(2.5) induce myocardial injury in hyperlipidemic mice through ROS-pyroptosis signaling pathway.
Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers.
Effects of limonin treatment on the survival of random skin flaps in mice.
Effects of folic acid on oxidative damage of kidney in lead-exposed rats.
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis.
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance.
Fibroblast Growth Factor 19 Improves LPS-Induced Lipid Disorder and Organ Injury by Regulating Metabolomic Characteristics in Mice.
The Attenuation of Chronic Ulcerative Colitis by (R)-salbutamol in Repeated DSS-Induced Mice.
Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage.
Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury.
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis.
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.
Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia.
Protective Effects of Cannabidiol on Chemotherapy-Induced Oral Mucositis via the Nrf2/Keap1/ARE Signaling Pathways.
Theaflavin-3,3'-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis.
GSK 650394 Inhibits Osteoclasts Differentiation and Prevents Bone Loss via Promoting the Activities of Antioxidant Enzymes In Vitro and In Vivo.
Discovery of Therapeutic Candidates for Diabetic Retinopathy Based on Molecular Switch Analysis: Application of a Systematic Process.
Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
Geraniin Protects against Cerebral Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Neuronal Apoptosis via Regulation of the Nrf2/HO-1 Pathway.
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury.
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress.
Activated AMP-activated protein kinase prevents hepatic steatosis, oxidative stress and inflammation in primary chicken hepatocytes.
Nodosin Exerts an Anti-Colorectal Cancer Effect by Inhibiting Proliferation and Triggering Complex Cell Death in Vitro and in Vivo.
(±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H(2)O(2) Through Activation of Nrf2 Pathway.
Co-Treatment With Resveratrol and FGF1 Protects Against Acute Liver Toxicity After Doxorubicin Treatment via the AMPK/NRF2 Pathway.
Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects.
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Relief Effects of Icariin on Inflammation-Induced Decrease of Tight Junctions in Intestinal Epithelial Cells.
Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs.
4-Ethylguaiacol Modulates Neuroinflammation and Promotes Heme Oxygenase-1 Expression to Ameliorate Brain Injury in Ischemic Stroke.
Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway.
Scorias spongiosa Polysaccharides Promote the Antioxidant and Anti-Inflammatory Capacity and Its Effect on Intestinal Microbiota in Mice.
Kaempferol From Penthorum chinense Pursh Attenuates Hepatic Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Inflammation Through Activation of the Nrf2/HO-1 Signaling Pathway.
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1.
A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Zoledronic acid induces ferroptosis by reducing ubiquinone and promoting HMOX1 expression in osteosarcoma cells.
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis.
Berberine prevents lethal EV71 neurological infection in newborn mice.
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.
Sunitinib induced hepatotoxicity in L02 cells via ROS-MAPKs signaling pathway.
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response.
Protective effects of di-caffeoylquinic acids from Artemisia selengensis Turcz leaves against monosodium urate-induced inflammation via the modulation of NLRP3 inflammasome and Nrf2 signaling pathway in THP-1 macrophages.
Dendrobium officinale polysaccharide inhibits vascular calcification via anti-inflammatory and anti-apoptotic effects in chronic kidney disease.
Protective Mechanism of Electroacupuncture on Peripheral Neurotoxicity Induced by Oxaliplatin in Rats.
Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats.
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Hedyotis diffusa injection induces ferroptosis via the Bax/Bcl2/VDAC2/3 axis in lung adenocarcinoma.
Resveratrol and FGF1 Synergistically Ameliorates Doxorubicin-Induced Cardiotoxicity via Activation of SIRT1-NRF2 Pathway.
Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway.
Targeting NRF2 Sensitizes Esophageal Adenocarcinoma Cells to Cisplatin through Induction of Ferroptosis and Apoptosis.
Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway.
Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling.
A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells.
Carbon tetrachloride exposure induces ovarian damage through oxidative stress and inflammatory mediated ovarian fibrosis.
Quercetin in Tonglong Qibi decoction ameliorates testosterone-induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress.
1,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes.
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO-1 signaling pathway in mice.
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis.
LipoxinA(4) analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Sodium butyrate reduces overnutrition-induced microglial activation and hypothalamic inflammation.
Gandouling Mitigates CuSO(4)-Induced Heart Injury in Rats.
Preparation of curcumin-loaded cochleates: characterisation, stability and antioxidant properties.
Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease.
Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
Integrated Analysis of Transcriptome and microRNA Profile Reveals the Toxicity of Euphorbia Factors toward Human Colon Adenocarcinoma Cell Line Caco-2.
p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression.
Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells.
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway.
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.
OL-FS13 alleviates experimental cerebral ischemia-reperfusion injury.
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6.
Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury.
Gallic acid ameliorates calcium oxalate crystal-induced renal injury via upregulation of Nrf2/HO-1 in the mouse model of stone formation.
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages.
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis.
BP5 alleviates endotoxemia-induced acute lung injury by activating Nrf2 via dual regulation of the Keap1-Nrf2 interaction and the Akt (Ser473)/GSK3β (Ser9)/Fyn pathway.
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Aberrant expression of KDM1A inhibits ferroptosis of lung cancer cells through up-regulating c-Myc.
Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism.
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
Protective effect of rutin against diabetes-associated cognitive decline in rats.
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury.
ROS-responsive liposomes as an inhaled drug delivery nanoplatform for idiopathic pulmonary fibrosis treatment via Nrf2 signaling.
A Combination therapy using an mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells and restricts renal tumor growth following organ transplantation.
Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNA‑binding protein RBFOX1 in this disease.
Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats.
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
HMGB2 causes photoreceptor death via down-regulating Nrf2/HO-1 and up-regulating NF-κB/NLRP3 signaling pathways in light-induced retinal degeneration model.
BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection.
Phenotypic characterization of Cdkl5-knockdown neurons establishes elongated cilia as a functional assay for CDKL5 Deficiency Disorder.
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
DHA-Enriched Phospholipids and EPA-Enriched Phospholipids Alleviate Lipopolysaccharide-Induced Intestinal Barrier Injury in Mice via a Sirtuin 1-Dependent Mechanism.
Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis.
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.
Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.
2-Fluorofucose Attenuates Hydrogen Peroxide-Induced Oxidative Stress in HepG2 Cells via Nrf2/keap1 and NF-κB Signaling Pathways.
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Nephrotoxicity evaluation of 3-monochloropropane-1,2-diol exposure in Sprague-Dawley rats using data-independent acquisition-based quantitative proteomics analysis.
Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
Antagonistic effects of selenium on lead-induced oxidative stress and apoptosis of Leydig cells in sheep.
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.
Different cellular mechanisms from low- and high-dose zinc oxide nanoparticles-induced heart tube malformation during embryogenesis.
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation.
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration.
Early-life galacto-oligosaccharides supplementation alleviates the small intestinal oxidative stress and dysfunction of lipopolysaccharide-challenged suckling piglets.
Novel Probiotic Lactic Acid Bacteria Were Identified from Healthy Infant Feces and Exhibited Anti-Inflammatory Capacities.
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Selenium Status in Diet Affects Nephrotoxicity Induced by Cisplatin in Mice.
Mitigation of doxorubicin-induced cardiotoxicity with an H(2)O(2)-Activated, H(2)S-Donating hybrid prodrug.
Ophiopogonin D'-induced mitophagy and mitochondrial damage are associated with dysregulation of the PINK1/Parkin signaling pathway in AC16 cells.
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Maackiain protects against sepsis via activating AMPK/Nrf2/HO-1 pathway.
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injury.
Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway.
Cyclo(-Phe-Phe) alleviates chick embryo liver injury via activating the Nrf2 pathway.
Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway.
The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate.
Andrographolide protects bone marrow mesenchymal stem cells against glucose and serum deprivation under hypoxia via the NRF2 signaling pathway.
Oxidative injury induced by drinking water disinfection by-products dibromoacetonitrile and dichloroacetonitrile in mouse hippocampal neuronal cells: The protective effect of N-acetyl-L-cysteine.
An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy.
Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4.
Procyanidin B2 Alleviates Heat-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway.
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response.
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Silent information regulator 1 ameliorates oxidative stress injury via PGC-1α/PPARγ-Nrf2 pathway after ischemic stroke in rat.
Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice.
Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism.
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway.
Protective effects of hydroxy-α-sanshool from the pericarp of Zanthoxylum bungeanum Maxim. On D-galactose/AlCl(3)-induced Alzheimer's disease-like mice via Nrf2/HO-1 signaling pathways.
Betulinic acid-nucleoside hybrid prevents acute alcohol -induced liver damage by promoting anti-oxidative stress and autophagy.
Synthesis and biological evaluation of novel schisanhenol derivatives as potential hepatoprotective agents.
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo.
Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway.
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling.
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway.
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
18β-Glycyrrhetinic acid suppresses allergic airway inflammation through NF-κB and Nrf2/HO-1 signaling pathways in asthma mice.
Hydroxytyrosol Alleviates Dextran Sulfate Sodium-Induced Colitis by Modulating Inflammatory Responses, Intestinal Barrier, and Microbiome.
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury.
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Overexpressed mitogen-and stress-activated protein kinase 1 promotes the resistance of cytarabine in acute myeloid leukemia through brahma related gene 1-mediated upregulation of heme oxygenase-1.
Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities.
Regorafenib and reactive metabolite of sunitinib activate inflammasomes: Implications for multi tyrosine kinase inhibitor-Iiduced immune related adverse events.
Acteoside alleviates dextran sulphate sodium‑induced ulcerative colitis via regulation of the HO‑1/HMGB1 signaling pathway.
Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway.
Probiotic-fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota.
A multi-omic landscape of steatosis-to-NASH progression.
Hatched Eggshell Membrane Can Be a Novel Source of Antioxidant Hydrolysates to Protect against H(2)O(2)-Induced Oxidative Stress in Human Chondrocytes.
Epigallocatechin Gallate Attenuates Gentamicin-Induced Nephrotoxicity by Suppressing Apoptosis and Ferroptosis.
Geniposidic Acid from Eucommia ulmoides Oliver Staminate Flower Tea Mitigates Cellular Oxidative Stress via Activating AKT/NRF2 Signaling.
JMJD8 Functions as a Novel AKT1 Lysine Demethylase.
Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis.
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
Adipose-Derived Mesenchymal Stem Cells Alleviate Hypertrophic Scar by Inhibiting Bioactivity and Inducing Apoptosis in Hypertrophic Scar Fibroblasts.
Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling.
Alleviating effects of selenium on fluoride-induced testosterone synthesis disorder and reproduction toxicity in rats.
The Nrf2 inhibitor brusatol synergistically enhances the cytotoxic effect of lapatinib in HER2-positive cancers.
Dioscin alleviates Alzheimer's disease through regulating RAGE/NOX4 mediated oxidative stress and inflammation.
Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells.
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer in Vitro and in Vivo.
Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs.
Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response.
4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury.
New mechanism of nephrotoxicity of triptolide: Oxidative stress promotes cGAS-STING signaling pathway.
Fermented noni (Morinda citrifolia L.) fruit juice improved oxidative stress and insulin resistance under the synergistic effect of Nrf2/ARE pathway and gut flora in db/db mice and HepG2 cells.
Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
N-acetylcysteine promotes cyclic mechanical stress-induced osteogenic differentiation of periodontal ligament stem cells by down-regulating Nrf2 expression.
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Neuron derived fractalkine promotes microglia to absorb hematoma via CD163/HO-1 after intracerebral hemorrhage.
Novel oral edaravone attenuates diastolic dysfunction of diabetic cardiomyopathy by activating the Nrf2 signaling pathway.
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels.
miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia-reperfusion injury in steatotic grafts.
Relationship between Neuroprotective Effects and Structure of Procyanidins.
MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis.
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury.
Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury.
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Notoginsenoside R1 Protects Against High Glucose-Induced Cell Injury Through AMPK/Nrf2 and Downstream HO-1 Signaling.
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischaemia.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway.
Gastrodin Promotes the Survival of Random-Pattern Skin Flaps via Autophagy Flux Stimulation.
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
GPX4-Regulated Ferroptosis Mediates S100-Induced Experimental Autoimmune Hepatitis Associated with the Nrf2/HO-1 Signaling Pathway.
DCA Protects against Oxidation Injury Attributed to Cerebral Ischemia-Reperfusion by Regulating Glycolysis through PDK2-PDH-Nrf2 Axis.
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Buyang Huanwu Decoction Enhances Revascularization via Akt/GSK3β/NRF2 Pathway in Diabetic Hindlimb Ischemia.
Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.
Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies.
Methylcobalamin Protects Melanocytes from H(2)O(2)-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway.
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
DPHC From Alpinia officinarum Ameliorates Oxidative Stress and Insulin Resistance via Activation of Nrf2/ARE Pathway in db/db Mice and High Glucose-Treated HepG2 Cells.
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway.
Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis.
Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats.
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis.
The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway.
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Effects of Bacillus subtilis on jejunal integrity, redox status, and microbial composition of intrauterine growth restriction suckling piglets.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage by inhibiting the overactivation of primordial follicles and follicular atresia.
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.
Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure.
An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury.
Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway.
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms.
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Autophagy deficiency exacerbates acute lung injury induced by copper oxide nanoparticles.
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress.
Cordyceps acid alleviates lung cancer in nude mice.
Chondrocyte ferroptosis contribute to the progression of osteoarthritis.
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
FGF1(ΔHBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption.
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
The nephroprotective effects and mechanisms of rehmapicrogenin include ROS inhibition via an oestrogen-like pathway both in vivo and in vitro.
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch.
Protective effect of scorpion venom heat-resistant synthetic peptide against PM(2.5)-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis.
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
A novel PGAM5 inhibitor LFHP-1c protects blood-brain barrier integrity in ischemic stroke.
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Proteomics analysis in the kidney of mice following oral feeding Realgar.
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury.
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Polydatin mitigates pancreatic β-cell damage through its antioxidant activity.
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Marine algal polysaccharides alleviate aflatoxin B1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers.
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Phytochemical characterization and hepatoprotective effect of active fragment from Adhatoda vasica Nees. against tert-butyl hydroperoxide induced oxidative impairment via activating AMPK/p62/Nrf2 pathway.
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway.
Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation.
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway.
Design, synthesis, and evaluation of mono-carbonyl analogues of curcumin (MCACs) as potential antioxidants against periodontitis.
The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis.
Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway.
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl(4)-induced liver injury in vivo.
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease.
A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis.
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Myricetin protects against H(2) O(2) -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation.
Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells.
Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system.
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κB Pathway.
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
Heme Oxygenase-1-Mediated Autophagy Protects against Oxidative Damage in Rat Nucleus Pulposus-Derived Mesenchymal Stem Cells.
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway.
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Inhibition of Brd4 by JQ1 Promotes Functional Recovery From Spinal Cord Injury by Activating Autophagy.
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis.
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats.
4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.
Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.
Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway.
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis.
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Kaempferol Protects Blood Vessels From Damage Induced by Oxidative Stress and Inflammation in Association With the Nrf2/HO-1 Signaling Pathway.
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway.
Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia reperfusion in mice.
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way.
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D(3) Plus Nicotine.
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation.
Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo.
Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis.
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Spinosin Inhibits Aβ(1-42) Production and Aggregation via Activating Nrf2/HO-1 Pathway.
Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats.
7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway.
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role.
Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System.
Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts.
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM(2.5) from Beijing, China, in Winter.
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Bach1-induced suppression of angiogenesis is dependent on the BTB domain.
Levo-corydalmine Attenuates Vincristine-Induced Neuropathic Pain in Mice by Upregulating the Nrf2/HO-1/CO Pathway to Inhibit Connexin 43 Expression.
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Polychlorinated biphenyl quinone promotes macrophage polarization to CD163(+) cells through Nrf2 signaling pathway.
Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8(+)CD28(-) T cells.
H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron.
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Syringin protects against colitis by ameliorating inflammation.
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling.
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl(4)-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Brainstem iron overload and injury in a rat model of brainstem hemorrhage.
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells.
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.
Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
Inhibition of Mitochondrial Complex I Aggravates Folic Acid-Induced Acute Kidney Injury.
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
CCl(4)-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Prevention of Huntington's Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress.
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress.
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
FGF10 Enhances Peripheral Nerve Regeneration via the Preactivation of the PI3K/Akt Signaling-Mediated Antioxidant Response.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation.
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2-HMOX1 axis.
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways.
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity.
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Predictable chronic mild stress promotes recovery from LPS-induced depression.
Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway.
The harmful effects of acute PM(2.5) exposure to the heart and a novel preventive and therapeutic function of CEOs.
Neuroprotective Effect of Dioscin on the Aging Brain.
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells.
Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
14-3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling.
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks.
Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms.
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Dietary Dihydroartemisinin Supplementation Attenuates Hepatic Oxidative Damage of Weaned Piglets with Intrauterine Growth Retardation through the Nrf2/ARE Signaling Pathway.
The memory improving effects of round scad (Decapterus maruadsi) hydrolysates on sleep deprivation-induced memory deficits in rats via antioxidant and neurotrophic pathways.
Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes.
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Deferoxamine Alleviates Iron Overload and Brain Injury in a Rat Model of Brainstem Hemorrhage.
NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway.
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Ochratoxin A causes mitochondrial dysfunction, apoptotic and autophagic cell death and also induces mitochondrial biogenesis in human gastric epithelium cells.
Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells.
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion.
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Liver injury induced in Balb/c mice by PM(2.5) exposure and its alleviation by compound essential oils.
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Cyclooxygenase‑2‑mediated upregulation of heme oxygenase 1 mitigates the toxicity of deuterium‑tritium fusion radiation.
Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells.
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling.
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88's effects on the gut microbiota.
Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2.
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.
α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage.
Non-Lethal Sonodynamic Therapy Inhibits Atherosclerotic Plaque Progression in ApoE-/- Mice and Attenuates ox-LDL-mediated Macrophage Impairment by Inducing Heme Oxygenase-1.
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms.
Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway.
Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice.
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H(2)S system: Role of oxidative stress and endoplasmic reticulum stress.
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Establishment and characterization of human osteosarcoma cells resistant to pyropheophorbide-α methyl ester-mediated photodynamic therapy.
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase.
Role of the cystathionine β-synthase/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the system.
Effect of ozone oxidative preconditioning on oxidative stress injury in a rat model of kidney transplantation.
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis.
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Global Transcriptomic Profiling of Cortex and Striatum: Cerebral Injury after Ischemia/Reperfusion in a Mouse Model.
The electrophilic character of quinones is essential for the suppression of Bach1.
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Heme-oxygenase-1 Production by Intestinal CX3CR1(+) Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis.
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway.
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats.
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
3H-1,2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis.
Desferrioxamine reduces ultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1.
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
High expression of heme oxygenase-1 in target organs may attenuate acute graft-versus-host disease through regulation of immune balance of TH17/Treg.
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats.
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice.
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell.
Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo.
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Potent effects of dioscin against obesity in mice.
tert-Butylhydroquinone mobilizes intracellular-bound zinc to stabilize Nrf2 through inhibiting phosphatase activity.
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Heme oxygenase-1 silencing increases the sensitivity of human osteosarcoma MG63 cells to arsenic trioxide.
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response.
Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection.
Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice.
Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-κB pathways.
Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium.
Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC.
Shen X, Yao J, Wang Z, Chen R, Li L, Xu X, Huang Y
PloS one 2026;21(3):e0344110
PloS one 2026;21(3):e0344110
Spatholobus suberectus Stem-Derived Extracellular Vesicle-Like Particles Attenuate Glucocorticoid-Induced Osteoporosis via NRF2/HO-1 Signaling.
Chen G, Li H, Chen R, Yao Y, Lian G, Bai L, Chen H, Zhang C, Chen G
International journal of nanomedicine 2026;21:585928
International journal of nanomedicine 2026;21:585928
Effect of Cordyceps militaris Extract on Visceral Adipose Tissue Changes After Ovariectomy in Rodents.
Kusama K, Fujii C, Yoshida K, Yoshie M, Adachi Y, Miyaoka H, Tamura K
International journal of endocrinology 2026;2026:6699051
International journal of endocrinology 2026;2026:6699051
Gan-Pi-Tong-Zhi Decoction Ameliorates OVA-Induced Asthma Through MAPK and Nrf2 Signaling Pathways and Regulating Gut Microbiota.
Liu J, Zhao Y, Xu L
Journal of inflammation research 2026;19:570124
Journal of inflammation research 2026;19:570124
Artificial neural network-based analysis of ferroptosis-associated molecular subtypes and immunological profiles in abdominal aortic aneurysm.
Li M, Xiao S, Qin Q, Fu K, Wang L, Li X, Li J
Frontiers in immunology 2026;17:1721069
Frontiers in immunology 2026;17:1721069
Multitarget mechanisms of the herb pair Achyranthes bidentata and Paeonia lactiflora Pall. in ameliorating hypertensive cardiomyopathy: combining network pharmacology and functional exploration.
Zhang Y, Wang Y, Liu J, Zhao Y, He Y, Yan P, Ren S, Lyu Y, Jia W, Sun Y, Lin S, Lin Y
Frontiers in pharmacology 2026;17:1717533
Frontiers in pharmacology 2026;17:1717533
ROS-Responsive Double-Layer Microneedles Enable Sequential Antibacterial and Immunomodulatory Therapy for Infected Wound Healing.
Zhang H, Wang Z, Zhu Y, Huang T, Xiu Z, Huang H, Li H, Xie J, Huang H, Liu M, Sun L, Lan Y, Guo L
Theranostics 2026;16(4):2052-2079
Theranostics 2026;16(4):2052-2079
Processed phellodendri Chinensis cortex attenuates diabetic nephropathy via ferroptosis inhibition through GPX4/SLC7A11/Nrf2/HO-1 signaling pathway.
Zhou Y, Xu G, Ren W, Chen Y, Jiang S, Zhang S, Ge X, Gao H, Zhang F
Journal of natural medicines 2026 May;80(3):776-796
Journal of natural medicines 2026 May;80(3):776-796
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Xu H, Li Y, Wang J, Xin Y, Xu Q, Qin X, Yang X, Yan Y, Chen Q, Chen Y, Zhang Y, Lu C, Xu K, Wang X
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Cannabidiol attenuates methamphetamine-induced psychosis via anti-oxidative stress: σ1R-mediated mitochondrial dysfunction as a critical pathway.
Liu L, Wang C, Tian Y, Yin Y, Rao M, Tao H, Luo C, Li J, Zeng X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158015
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158015
Macrophage Membrane-Cloaked, ROS-Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome.
Li W, Guan Y, Song N, Zhang F, Deng Z, Yin T, Yang Y, Conde J, Jin W, Yin Z
Advanced healthcare materials 2026 May;15(17):e05171
Advanced healthcare materials 2026 May;15(17):e05171
Mechanism of Bushen Wenyang Huayu Formula against oxidative damage by Let-7b-Bach1 in the treatment of endometriosis.
Zhang Y, Luo L, Liu L, Hu S, Niu R, Xi Y, Liu Q, Wu S, Sun Y, Zhao J, Zhang Y, He M
Journal of ethnopharmacology 2026 May 23;363:121392
Journal of ethnopharmacology 2026 May 23;363:121392
Gynostemma pentaphyllum polysaccharides alleviate ulcerative colitis in mice via the Nrf2/ROS/NLRP3 axis and modulation of the gut microbiota.
Qiu M, Yi Q, Luo M, Duan S, Zhang Z, Wu X, Chen T, Ma C, Cui T, Zhang B, Zhang Y, Li J, Guo S, Gao Y, Zhang D
Journal of ethnopharmacology 2026 May 23;363:121373
Journal of ethnopharmacology 2026 May 23;363:121373
Hepatitis C virus p7 regulates Core protein processing via signal peptide peptidase to promote virion assembly.
Wu M-J, Healy P, Chang C-W, Welsch C, Yi M
Journal of virology 2026 May 19;100(5):e0028826
Journal of virology 2026 May 19;100(5):e0028826
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
Zhang Y, Han Y, Li S, Shan R, Lin L, Gu Z, Wang R, Chen Y, Xiao J, An F, Hu C, He C
Redox biology 2026 Mar;90:103993
Redox biology 2026 Mar;90:103993
EGR1 promotes ferroptosis in endometriosis through transcriptional activation of HMOX1.
Yang F, Liu D, Hu L, Tan H, Wei Y, Yang R, Huang B, Zou Q, Wu Q, He Y, Mai H, Lan X, Yan Y, Huang Z, Huang X, Fu Z, Deng Z, Huang Q, Yao S, Liang Y
Molecular and cellular endocrinology 2026 Mar;613:112721
Molecular and cellular endocrinology 2026 Mar;613:112721
Role of connexin32 in zinc oxide nanoparticles induced hepatotoxicity.
Wei E, Wu L, Xia G, Zhong Y, Li LG, Chen H, Tang N
Toxicology mechanisms and methods 2026 Mar;36(3):403-411
Toxicology mechanisms and methods 2026 Mar;36(3):403-411
TPPU alleviates hepatic ischemia-reperfusion injury by regulating macrophage polarization.
Pan H, Lu J, Han T, Liang H, Zhang W, Hou W, Shen Z
Biochemical pharmacology 2026 Mar;245:117657
Biochemical pharmacology 2026 Mar;245:117657
M2 macrophage-derived exosome nanoplatform for targeted H(2)S delivery to alleviate hepatic ischemia-reperfusion injury via synergistic anti-oxidative, anti-inflammatory, and anti-ferroptotic effects.
Zuo T, Shi C, Li J, Li D, Luo X, Xu M, Su M, Lu H, Zhang Y, Hu X, Zhou Q, Shubhra QTH, He X, Cai X
Acta biomaterialia 2026 Mar;212:593-612
Acta biomaterialia 2026 Mar;212:593-612
Inhibition of Nrf2 Activity in Mitigating Cadmium-Induced Mitochondrial Damage and Pyroptosis.
Xu H, Yang J, Ye R, Cao M, Li S, Liu C, Li L
Biological trace element research 2026 Mar;204(3):1693-1705
Biological trace element research 2026 Mar;204(3):1693-1705
Crebanine protects against ovariectomy-induced bone loss by targeting Sirt1 to interfere with NF-κB acetylation and ROS activity.
Zhang H, Zhao X, Wang Z, Miao J, Hu X, Cui P, Jin C, Zhao X, Liang H, Ye H, Xu Y, Chen X, Wang W, Lu S
Journal of pharmaceutical analysis 2026 Mar;16(3):101426
Journal of pharmaceutical analysis 2026 Mar;16(3):101426
Multi-omics mapping identifies CYBA-mediated mitochondrial dysfunction driving macrophage polarization and ferroptosis via Nrf2 pathway in atherosclerosis.
Dong C, Shen R, Pan C, Zhang J, Yu K, Zeng Q
APL bioengineering 2026 Mar;10(1):016107
APL bioengineering 2026 Mar;10(1):016107
Curcumin protects against difenoconazole-induced kidney injury in carp by inhibiting ferroptosis through the Nrf2/GPX4 axis.
Zhang S, Li X, Gao Y, Dong Q, Jin X, Shi P, Dong J
Fish physiology and biochemistry 2026 Mar 5;52(2)
Fish physiology and biochemistry 2026 Mar 5;52(2)
IL-3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury.
Huang N, Zhang Q, Chen Y, Yu D, Liu R, Kang J, Fang X, Zhang Y, Bian H, Zhao Y, Yin Y, Zhang C, Jia Y, Chen Q, Fang Y, Li S, Li F, Jin Z, Ning B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e04511
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 31;:e04511
Atractylenolide III improves ovarian dysfunction and endometrial receptivity in a PCOS rat model by regulating Cybb-mediated oxidative stress.
Bai C, Liu J
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 30;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar 30;
USP1 promotes hepatocellular carcinoma progression by modulating mitophagy via stabilizing MCM3 to regulate the Keap1-Nrf2 axis.
Chen Z, Sun C, Wang Y, Duan X, Ma H, Zhou X, Chen S, Peng P
iScience 2026 Mar 20;29(3):114927
iScience 2026 Mar 20;29(3):114927
Retinoic Acid Alleviates TGEV-Induced Ferroptosis by Activating the p62-NRF2-GPX4/HO-1 Pathway and Iron Metabolism in Intestinal Epithelial Cells.
Yin C, Lai X, Pu J, Liu C, Luo Y, He J, Yu B, Che L, Wang Q, Wang H, Chen D, Wu A
Nutrients 2026 Mar 20;18(6)
Nutrients 2026 Mar 20;18(6)
P2 X 7 receptor deficiency ameliorates high-fat-induced cardiac remodeling by improving oxidative stress through PI3K/AKT/GSK3β-mediated regulation of Nrf2.
Shi X, Dong Y, Fan J, He S, You S, Feng J, Zhong X, Tong G, Huang Z
Journal of bioenergetics and biomembranes 2026 Mar 18;
Journal of bioenergetics and biomembranes 2026 Mar 18;
Dual action of SS31 via NRF2/HO-1: countering oxidative stress and metabolic dysfunction in ovarian aging.
Zhang G, Du X, Zhao Y, Zhi W, Wang L, Bai X, He L, Xie H, Liu J, Han C, Liu W
Journal of ovarian research 2026 Mar 17;19(1)
Journal of ovarian research 2026 Mar 17;19(1)
Viscum coloratum polysaccharide ameliorates hyperuricemic nephropathy by upregulating Nrf2 to inhibit TGF-β1/Smad3 and NLRP3/ASC/Caspase-1 pathways.
Zhang K, Sun S, Qiu H, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2026 Mar 1;358:120981
Journal of ethnopharmacology 2026 Mar 1;358:120981
Ethanol extract of Gastrodia elata Blume alleviates ischemic stroke by inhibiting oxidative stress and ferroptosis through the PI3K/AKT/Nrf2 pathway.
Wang Y, Liu J, Wu W, Xue J, Mu D, Wang F, Li W, Liu Y, Liang D, Aminah NS, Chai H, Mi Y, Hou Y
Journal of ethnopharmacology 2026 Mar 1;358:120956
Journal of ethnopharmacology 2026 Mar 1;358:120956
Mesenchymal Stem Cell-Lysate Sustained-Release Nano-Hydrogel Alleviates Spinal Cord Injury by Inhibiting Ferroptosis and Mitochondrial Intrinsic Apoptosis.
Sun ML, Wu H, Liu SY, Jiang CL, Zhou H, Hou A
International dental journal 2026 Jun;76(3):109557
International dental journal 2026 Jun;76(3):109557
Protean bio-heterojunction nanoparticle coating for dynamically modulating diabetic microenvironment.
Pan L, Zheng A, Huang N, Zhang S, Peng L, Zheng F, Cao L, Wang X, Jiang X
Biomaterials 2026 Jun;329:123912
Biomaterials 2026 Jun;329:123912
SIRT1 protects against UVA-induced photoaging by suppressing oxidative stress and FOXO3a acetylation in human dermal fibroblasts.
Ma W, Jiang M, Zhang J, Liu W, Dan Y, Sun W, Ma L, Xiang L, Ren J
Journal of photochemistry and photobiology. B, Biology 2026 Jun;279:113451
Journal of photochemistry and photobiology. B, Biology 2026 Jun;279:113451
STAT3 inhibition ameliorates cognitive dysfunction in type 2 diabetes mellitus by modulating astrocytes via Nrf2 pathway activation.
Wang J, Chen P, Li Y, Wang R, Ding W, Yu R, Qin Q, Wu R, Wei W, Shi J, Yuan H, Zhuang C, Sun Y
Free radical biology & medicine 2026 Jun;249:165-179
Free radical biology & medicine 2026 Jun;249:165-179
Enterolactone mitigates atherosclerosis by facilitating resolution of ferroptosis-associated intimal inflammation via the Keap1/Nrf2/GPX4 pathway.
Chai S, Zhang Y, Guo Y, Cao D, Wang J, Yan Y, Shi Y, Yuan Z, Wang X, Tong T, Zhen Z, Huo Y, Zhang K, Wang F, Liu GR, Li W, Xu X, Ban T, Liu SL, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158178
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158178
Farrerol mitigates fungal keratitis by enhancing fungal clearance and limiting inflammation through autophagy and Nrf2 pathway.
Yu B, Zhang L, Lin J, Wang Q, Chi M, Wang Z, Liu W, Wang S, Wei Z, Li C, Zhao G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158169
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158169
The Berberine Derivative BBR684 Inhibits VDAC Oligomerization to Suppress Ferroptosis in Acute Kidney Injury.
Jiang Z, Zhang W, Zhu J, Wang C, Chen G, Guo Y
Current therapeutic research, clinical and experimental 2026 Jun;104:100825
Current therapeutic research, clinical and experimental 2026 Jun;104:100825
Investigation of the Potential Anti-Diabetic Kidney Disease Mechanism of Gynura procumbens (Lour.) Merr via Transcriptomics Combined With Network Pharmacology.
Liu Y, Ruan W, Zhai S, Li L, Sun J, He M, Cao J
Rapid communications in mass spectrometry : RCM 2026 Jul 15;40(13):e70065
Rapid communications in mass spectrometry : RCM 2026 Jul 15;40(13):e70065
6-Gingerol alleviates NNK-induced lung carcinogenesis by boosting antioxidation and reducing inflammation.
Qu Z, Ding Y, Zhang L, Sun J, Wang T, Zhuang C
Free radical research 2026 Jan;60(1):1-15
Free radical research 2026 Jan;60(1):1-15
CDKN3 promoted triple-negative breast cancer by inhibiting ferroptosis through the upregulation of HSP90.
Zhao Q, Wang Y
Toxicology and applied pharmacology 2026 Jan;506:117629
Toxicology and applied pharmacology 2026 Jan;506:117629
Punicalagin Ameliorates Diabetic Cognitive Dysfunction by Inhibiting Neuroinflammation via the CX3CL1/CX3CR1 Axis.
Zhang R, Tan X, Zhang Y, Ma Y, You Z, Huang Y, Yang L
Phytotherapy research : PTR 2026 Jan;40(1):334-350
Phytotherapy research : PTR 2026 Jan;40(1):334-350
Neuroprotective effects of SRS11-92 against oxidative stress-induced senescence via Nrf2/HO-1/NF-κB in Alzheimer's disease models.
Guo Y, Cao H, Zuo C, Huang Y, Gu Z, Song Y, Chen X, Jiang Q, Wang F
Inflammopharmacology 2026 Jan;34(1):495-507
Inflammopharmacology 2026 Jan;34(1):495-507
Mechanism of tectorigenin in promoting thermal burn wound healing via the Nrf2-mediated ferroptosis pathway: Integrated pharmacological and experimental study.
Bashir A, Mei W, Zhang L, Khan MA, Nisar MF, Zhong JL
International journal of biological macromolecules 2026 Jan;339(Pt 1):149890
International journal of biological macromolecules 2026 Jan;339(Pt 1):149890
Structural characterization and multi-omics analysis of novel Saposhnikovia divaricata (Turcz.) Schischk acidic heteropolysaccharide alleviating acute liver injury.
Sun X, Zhang T, Zhu W, Jiang X, Wang S, Zhao Y, Bian X
International journal of biological macromolecules 2026 Jan;339(Pt 1):149819
International journal of biological macromolecules 2026 Jan;339(Pt 1):149819
High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE(‑/‑) mice via the NAD(+)‑mediated SIRT1/MFN2 pathway.
Gao S, Yao W, Yang J, Liu Y, Pei Z
Molecular medicine reports 2026 Jan;33(1)
Molecular medicine reports 2026 Jan;33(1)
Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway.
Hsia CH, Yang CM, Chang CC, Yen TL, Darmanto AG, Huang CC, Sheu JR
Molecular medicine reports 2026 Jan;33(1)
Molecular medicine reports 2026 Jan;33(1)
Ammonium tetrathiomolybdate ameliorates heat stroke-induced murine liver injury by activating the Nrf2/HO-1 signaling pathway and inhibiting oxidative stress.
Jiang GL, Long LZ, Zhang XY, Yao TT, Cheng XY, Yu P, Zou LJ, He YJ, Jiang M, Meng J
Free radical biology & medicine 2026 Jan;242:535-548
Free radical biology & medicine 2026 Jan;242:535-548
Eugenol attenuates intervertebral disc degeneration by inhibiting nucleus pulposus cell ferroptosis via the Nrf2/GPX4 pathway.
Sun S, Lu X, Yang S, Liang H, Lyu G, Chen Y, Yu L, Gao Z, Wang J, Xiao P, Jin L, Huang C, Wang X
Free radical biology & medicine 2026 Jan;242:508-520
Free radical biology & medicine 2026 Jan;242:508-520
SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization.
Jiang T, Zhang H, Sun Y, Ji X, Xue L, Pan C, Guo Y, Xu F
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00772
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2026 Jan;23(1):e00772
The Tetradium ruticarpum-Zingiber officinale Roscoe herb pair inhibits atherogenic events: A study of the synergistic effects and active ingredient combination of a two-herb formula.
Chi C, Yang X, Li C, Li Z, Yang S, Du Y, Huang W, Liu R
Fitoterapia 2026 Jan;188:107030
Fitoterapia 2026 Jan;188:107030
Pharmacological inhibition of PGK1 by genipin reduces inflammation and oxidative damage in osteoarthritis.
Li M, Peng Y, Xiao Q, Chen S, Zhang C, Chen H, Zhao Y, Chang S, Qiu L, Zhang L, Guo X, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157729
Justicia procumbens promotes hair growth and ameliorates age-related deterioration of hair health.
Choi PG, Lee E, Kim JM, Kim D, Kim HS, Park SH, Seo HD, Hahm JH, Ahn J, Lee H, Sung MJ, Jung CH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157609
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157609
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Qin L, Zhao B, Xiong Y, Chen L, Qi S, Ma Y, Zeng H, Song Y, Liu W, Tian T, Ge G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Ononin promotes bone marrow-derived mesenchymal stem cells survival via SIRT6/Nrf2 signaling for myocardial infarction repair.
Hu C, Xu T, Xu H, Pang M, Zhang G, Han X, Zhang J, Liu M, Hua Y, Chen G, Zhong B, Deng B, Tu Y, Chen T, Hu S, Liu B, Zhou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157514
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157514
Spatial Transcriptome Analysis Reveals Factors Involved in Actinic Cheilosis Transformation to Squamous Cell Carcinoma of the Lip.
Choi ME, Yang HJ, Jung JM, Lee WJ, Lee MW, Won CH
The Journal of investigative dermatology 2026 Jan;146(1):103-115.e21
The Journal of investigative dermatology 2026 Jan;146(1):103-115.e21
HucMSC-derived exosomes alleviate chemotherapy-induced premature ovarian insufficiency via SMURF1-mediated inhibition of ferroptosis in ovarian granulosa cells.
Xu B, Han H, Hao Y, Shang Y, Deng Y, Zhang Z, Ding L, Pei X, Fu X
Stem cell research & therapy 2026 Jan 8;17(1):70
Stem cell research & therapy 2026 Jan 8;17(1):70
Chlorella-derived extracellular vesicle-based nanogels suppress cGAS-STING for treatment of radiation-induced lung injury.
Hu H, Lu F, Zhang W, Zhang Z, Cui J, Lei X, Xia J, Xu F
Nature communications 2026 Jan 8;17(1):1403
Nature communications 2026 Jan 8;17(1):1403
Indole-3-aldehyde Preserves Gingival Epithelial Barrier Structure and Function Via AhR/Nrf2 Signaling Pathway.
Wu L, Wu S, Deng Y, Li J, Zhang C, Wang Y, Zhao C, Gao L
Inflammation 2026 Jan 7;49(1):33
Inflammation 2026 Jan 7;49(1):33
Propyl Gallate Attenuates Cognitive Deficits Induced by Chronic Sleep Deprivation Through Nrf2 Activation and NF-κB Inhibition.
Zhang X, Cui J, Liu L, Sun J, Fan B, Wang F, Lu C
Antioxidants (Basel, Switzerland) 2026 Jan 7;15(1)
Antioxidants (Basel, Switzerland) 2026 Jan 7;15(1)
Methotrexate-triggered ferroptosis suppresses oral cancer progression by phosphorylated KEAP1-mediated NRF2 degradation to inhibit SLC7A11/GPX4 signaling pathway.
Yu C, Zhang T, Yuan J, Su Y, Zhang H, Xu L, Li X, Cui J, Xu R, Zhou Y, Huang H, Zhou X, Zhou Y, Zhang E
Cancer cell international 2026 Jan 6;26(1):64
Cancer cell international 2026 Jan 6;26(1):64
Integrative multiomics analysis reveals the ameliorative effects of Xiasangju on metabolic dysfunction-associated steatohepatitis.
Xiang F, He Z, Yang C, Lin L, Peng Q, Zhang Z
Chinese medicine 2026 Jan 4;21(1):3
Chinese medicine 2026 Jan 4;21(1):3
Binankadsurin A from Kadsura coccinea Fruits Ameliorates Acetaminophen-Induced Liver Injury Through Inhibiting Oxidative Stress by Keap1/Nrf2/HO-1 Pathway.
Kemayou GPM, Wang Y, Aamer M, Li C, Liu S, Yu H, Peng C, Kouam SF, Li B, Wang W, Yang Y
Nutrients 2026 Jan 26;18(3)
Nutrients 2026 Jan 26;18(3)
Chrysanthemum 3,5-O-dicaffeoylquinic acid ameliorates mouse alcoholic liver injury by suppressing the TLR-4/NF-κB pathway and restoring glycerophospholipid homeostasis.
Ma YL, Li Z, Wu QL, Li J, Guo X, Mao TL, Thakur K, Wei ZJ
Food & function 2026 Jan 26;17(2):846-860
Food & function 2026 Jan 26;17(2):846-860
Heme as a Pro-Inflammatory Stimulus in Abdominal Aortic Aneurysm.
Ding Y, Potor L, Sótonyi P, Szappanos Á, Gyurok GP, Póliska S, Patsalos A, Méhes G, Beke L, Sikura KÉ, Zavaczki E, Gáll T, Pethő D, Fintha A, Nagy B, Juhász B, Nagy L, Balla G, Balla J
Antioxidants (Basel, Switzerland) 2026 Jan 23;15(2)
Antioxidants (Basel, Switzerland) 2026 Jan 23;15(2)
LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.
Weindel CG, Coleman AK, Ellzey LM, Kumar S, Chaisson SL, Davis JR, Patrick KL, Watson RO
Journal of immunology (Baltimore, Md. : 1950) 2026 Jan 21;215(1)
Journal of immunology (Baltimore, Md. : 1950) 2026 Jan 21;215(1)
ALDH2/eIF3E Interaction Modulates Protein Translation Critical for Cardiomyocyte Ferroptosis in Acute Myocardial Ischemia Injury.
Chen X, Yu X, Zhong S, Sha P, Li R, Xu X, Liang N, Zhang L, Li L, Zhang J, Zhou M, Lv T, Ma H, Wang Y, Ye Y, Yin C, Chen S, Tian J, Sun A, Wang W, Yan D, Yang HT, Huang H, Li P, Yin H
Circulation 2026 Jan 20;153(3):164-184
Circulation 2026 Jan 20;153(3):164-184
Revealing the anti-tumor mechanisms of aromatic oil from Amomum villosum through integrated network pharmacology, bioinformatics, machine learning, single-cell sequencing, and cell experiments.
Deng K, Wei Y, Yu K, Mei Y, Han S, Yan Q
Biochemical and biophysical research communications 2026 Jan 18;796:153153
Biochemical and biophysical research communications 2026 Jan 18;796:153153
Repurposing metformin for treating osteoarthritis via leveraging Nrf2 signaling.
Zhong Y, Chen J, Shi N, Yu J, Wang S, Wang G, Liu M, Yang X, Cheng X
Scientific reports 2026 Jan 10;16(1):4966
Scientific reports 2026 Jan 10;16(1):4966
Quercetin-chitooligosaccharide ionic complex: molecular stabilization and microbiota mediated glycemic modulation.
Li J, Wang L, Liu X, Liu Y, Matsui T, Chen S, Cao R
Food chemistry 2026 Jan 1;498(Pt 2):147277
Food chemistry 2026 Jan 1;498(Pt 2):147277
Contribution of ferroptosis and SLC7A11 to light-induced photoreceptor degeneration.
Huang X, Zhang Y, Jiang Y, Li T, Yang S, Wang Y, Yu B, Zhou M, Zhang G, Zhao X, Sun J, Sun X
Neural regeneration research 2026 Jan 1;21(1):406-416
Neural regeneration research 2026 Jan 1;21(1):406-416
Carnosic acid attenuates ventilator-induced diaphragmatic dysfunction via activation of the Nrf2/HO-1 pathway.
Liu Z, Yu Q, Zhou X, Ma H, Wei R, Xia J
International immunopharmacology 2026 Jan 1;168(Pt 2):115926
International immunopharmacology 2026 Jan 1;168(Pt 2):115926
Nicotinamide N-methyltransferase mediates redox regulation and colonic epithelial barrier impairment by SIRT1/PPAR-γ/NLRP6/NRF2 axis in inflammatory bowel disease.
Chen C, Tao M, Wang L, Yan W, Lin R, Fu Y
International immunopharmacology 2026 Jan 1;168(Pt 2):115882
International immunopharmacology 2026 Jan 1;168(Pt 2):115882
Lycium barbarum polysaccharide LBP3 alleviates 5-Fluorouracil-induced intestinal injury via a mechanism associated with activating Nrf2 and improving mitochondrial function.
Xie X, Cai Y, Xu R, Yang C, Li P, Zhu Y, Luo X, Zhou L, Wang Q
International immunopharmacology 2026 Jan 1;168(Pt 2):115879
International immunopharmacology 2026 Jan 1;168(Pt 2):115879
Forsythoside B protects cartilage and subchondral bone in osteoarthritis by regulating the Nrf2/NF - κ B signaling pathway.
Zhang H, He Z, Wang H, Lu F, Chen H
International immunopharmacology 2026 Jan 1;168(Pt 1):115762
International immunopharmacology 2026 Jan 1;168(Pt 1):115762
Modulation of Macrophage ferroptosis under the guide of infrared thermography promotes the healing of pressure injuries.
Jiang X, Zhang X, Deng H, Lin L, Wang Y, Wang Y, Huang J, Yang N, Xu S, Wang J, Shi K, Tao K, Chen Z, Cai F, Zhou K, Xiao J
Journal of advanced research 2026 Feb;80:265-285
Journal of advanced research 2026 Feb;80:265-285
Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer.
Mei J, Tian HX, Zhang XY, Chen YS, Wang LY, Zhang Z, Zhang YL, Rong DC, Zeng J, Dong M, Gao Y, Yin JY, Wu HJ, Wang PY, Zhang W
Journal of advanced research 2026 Feb;80:1121-1137
Journal of advanced research 2026 Feb;80:1121-1137
Manganese oxide nanozyme-loaded CO-releasing halloysite nanotubes for remodeling colonic immune, microbiota, and intestinal barrier homeostasis with concurrent pain relief in ulcerative colitis.
Zhang H, Zhou L, Zhou Q, Wen H, Lu H, Li J, Yu L, Li H, Zhu Y, Xu M, Lu B, Shi C, Zhang Y, Hu X, Shubhra QTH, He X, Cai X
Bioactive materials 2026 Feb;56:136-159
Bioactive materials 2026 Feb;56:136-159
Cardiac oxidative damage and mitochondrial dysfunction induced by manganese deficiency are probably associated with the inhibition of the Nrf2 signaling pathway.
Xu H, Hou W, Liu L, Wang X, Pu Y, Liu Z
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2026 Feb;39(1):167-179
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2026 Feb;39(1):167-179
Intranasal delivery of Odorranalectin-modified lipid nanoparticles for multi-targeted therapy of Alzheimer's disease.
Zhang Y, Yin C, Tian Y, Li X, Wang H, Han S, Chen H, Hou H
Materials today. Bio 2026 Feb;36:102764
Materials today. Bio 2026 Feb;36:102764
Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice.
Xiao Q, Zhou S, Tang B, Zhu Y
CNS neuroscience & therapeutics 2026 Feb;32(2):e70770
CNS neuroscience & therapeutics 2026 Feb;32(2):e70770
Cannabidiol alleviates methamphetamine-induced autophagy and oxidative stress by suppressing sigma 1 receptor expression.
Li Y, Liu L, Miao L, Zhang Y, Li XD, Sun T, Zeng XF, Huang J, Liu JX
Cellular signalling 2026 Feb;138:112280
Cellular signalling 2026 Feb;138:112280
Neuron-Derived Sema3B Facilitates Microglial Hematoma Clearance After Intracerebral Hemorrhage.
Huang B, Chen A, Zhou T, Xu Y, Sun Y, He Q
Antioxidants (Basel, Switzerland) 2026 Feb 8;15(2)
Antioxidants (Basel, Switzerland) 2026 Feb 8;15(2)
Design, synthesis, and neuroprotective evaluation of chiral butylphthalide-ligustrazine hybrids via the Keap1-Nrf2 pathway in ischemic stroke.
Zuo C, Xie H, Shen H, Wang J, Li G, Hou Q, Sun G, Tian Y
European journal of medicinal chemistry 2026 Feb 5;303:118438
European journal of medicinal chemistry 2026 Feb 5;303:118438
Mangosteen (Garcinia mangostana) Pericarp and Leaf Tinctures Inhibit LPS-Induced Pro-Inflammatory Responses in Macrophages and Activate Nrf2.
Tocmo R, Nauman MC, Huang Y, Subedi P, Johnson JJ
Nutrients 2026 Feb 5;18(3)
Nutrients 2026 Feb 5;18(3)
Scutellarin alleviates ferroptosis in cigarette smoke-induced chronic obstructive pulmonary disease via activation of the PI3K/AKT/Nrf2 signaling pathway.
Ding K, He X, Gou Y, Xiao B, Zhong X, Luo Y, Su J, Liang Y, Song Z, Tan S, Ma L
Journal of ethnopharmacology 2026 Feb 28;357:120870
Journal of ethnopharmacology 2026 Feb 28;357:120870
The dual functions of a nor-sesquiterpene-triazole derivative against influenza A viruses through the activation of the Nrf2/HO-1 signaling pathway and interaction with hemagglutinin.
Zhou S, Wei J, Li S, Qiu J, Ma S, He J
RSC medicinal chemistry 2026 Feb 27;17(3):1735-48
RSC medicinal chemistry 2026 Feb 27;17(3):1735-48
Chlorogenic acid exerts anti-inflammation and neuroprotective effect in pentylenetetrazole-induced epilepsy mouse model by regulating microglia polarization via Nrf2/HO-1 pathway.
Sun Y, Wang J, Zhang A, Hu A, Wu L
Neuroscience letters 2026 Feb 26;873:138493
Neuroscience letters 2026 Feb 26;873:138493
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
Zhang H, Zhang D, Wang Z, Liu K, Xu C, Sun H, Yan Z, Li C, Lu B, Yin Y, Zhao C, Niu Y, Li W
Biology direct 2026 Feb 26;21(1)
Biology direct 2026 Feb 26;21(1)
Quercetin Attenuates Iron Overload-Induced Renal Injury via Activating Nrf2/xCT/GPX4 Signaling to Inhibit Ferroptosis.
Wang X, Li W, Yuan W, Wei Z, Yang Z, Zhang Z, Sun Z, Ji G, Hu H
Life (Basel, Switzerland) 2026 Feb 25;16(3)
Life (Basel, Switzerland) 2026 Feb 25;16(3)
A novel mechanism of chlorogenic acid against type 2 diabetes-induced diabetic retinopathy: suppressing ferroptosis via NRF2/xCT/GPX4 and STAT3 signaling.
Zheng J, Wang X, Guo Y, Feng L
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb 23;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb 23;
[Veratric acid relieves oxidative stress and DSS-induced colitis in mice by activating the Nrf2/HO-1 signaling pathway].
Yin L, Zhang K, Qiao T, Niu M, Yin L, Liu X, Geng Z, Li J, Hu J
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2026 Feb 20;46(2):403-411
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2026 Feb 20;46(2):403-411
Diosmetin, an active ingredient of Schizonepeta tenuifolia, alleviates acne by regulating inflammation and oxidative stress.
Pan Y, Sun R, Thomas ER, Pan S, Yang L, Wang W, Chen L, Li X
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb 18;
Naunyn-Schmiedeberg's archives of pharmacology 2026 Feb 18;
Fascin-1 Limits Secondary Damage by Preventing Oxidative‑Stress‑Induced Microglial Death After Spinal Cord Injury.
Zhan F, Xu D, Shi T, Niu H, Wang S, Feng E, Cao Y
Neurochemical research 2026 Feb 17;51(2):75
Neurochemical research 2026 Feb 17;51(2):75
Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity.
Song J, Liu T, Yang J, Zhao L, Su J, Li Z, Ma R, Wen X, Cheng P
Journal of virology 2026 Feb 17;100(2):e0165625
Journal of virology 2026 Feb 17;100(2):e0165625
Marine trichodermamide B inhibits prostate cancer progression via catalase inhibition-induced apoptosis.
Fang W, Chen C, Nie M, Liu Q, Huang T, Gao C, Liu Y, Zhou X, Wang X
Cell communication and signaling : CCS 2026 Feb 16;24(1)
Cell communication and signaling : CCS 2026 Feb 16;24(1)
Association and Toxic Mechanism Between Foodborne OTA Exposure and Embryonic Development.
Yao T, Zhu X, Ma J, Song G, Hu Y, Yan Y
Journal of applied toxicology : JAT 2026 Feb 12;
Journal of applied toxicology : JAT 2026 Feb 12;
Remimazolam alleviates acute lung injury by inhibiting ferroptosis: a multi-omics system pharmacology approach with experimental validation.
Li R, Qin L, Ren J, Deng G, Zhang C, Li J, Zhang J, Gao Y, Wang G
European journal of medical research 2026 Feb 12;
European journal of medical research 2026 Feb 12;
Carbon-based nanomaterials induce ovarian dysfunction via NLRP3 inflammasome-mediated pyroptosis in granulosa cells.
Wei S, Chen D, Wang J, Wu C, Tang W, Xue L, Feng Y, Dai Y, Guo Y, Zheng P, Song Y, Dai J, Wang S, Wu M
Journal of advanced research 2026 Feb 12;
Journal of advanced research 2026 Feb 12;
Antioxidant properties of low-molecular-weight Ulva prolifera polysaccharides against H₂O₂-induced oxidative damage in BRL 3A cells and zebrafish.
Tan J, Zheng Y, Ahn G, Wang L, Mao X
Food chemistry 2026 Feb 1;501:147475
Food chemistry 2026 Feb 1;501:147475
Inhibition of MAGL ameliorates glucocorticoid-induced bone loss by regulating the Nrf2 signaling.
Huang C, Wang X, Liu S, Xiao P, Lu Z, Xu Y, Tian Y
Free radical biology & medicine 2026 Feb 1;243:67-81
Free radical biology & medicine 2026 Feb 1;243:67-81
Microglial HMOX1 drives retinal angiogenesis via modulation of endothelial STAT3 signaling.
Liu Y, Tang J, Wei P, Yu Z, Wu Z, Zhao X, Qi H, Liu P, Zheng M, Mi S, Du W, Vavvas DG, Cui K, Zhang G
Free radical biology & medicine 2026 Feb 1;243:29-42
Free radical biology & medicine 2026 Feb 1;243:29-42
An intrabody targeting PHD2 protects mice against acetaminophen-induced liver injury by attenuating ferroptosis.
Ren Z, Wang Y, Cheng C, Zhang Y, Liu Y, Wei Y, Liu Z, Zhang J, Shi Z, Yu J, Hu W, Ye J, Wang J, Qiu S, Li G
Free radical biology & medicine 2026 Feb 1;243:260-275
Free radical biology & medicine 2026 Feb 1;243:260-275
USP7 deletion promotes osteoclastogenesis via stimulating NF-κB and attenuating Nrf2/HO-1 signaling pathway.
Abulimiti D, Aihemaiti S, Wei K, Zhang Z, Kan Y, Tao S, Liu H
International immunopharmacology 2026 Feb 1;170:116094
International immunopharmacology 2026 Feb 1;170:116094
Qigui didang decoction alleviates renal injury in a diabetic kidney disease model with metabolic memory features: association with ferroptosis and the SIRT1/Nrf2 pathway.
Wu Y, Fan L, You H, Lu Y, Lin M
Pharmaceutical biology 2026 Dec;64(1):536-555
Pharmaceutical biology 2026 Dec;64(1):536-555
Dibutyl phthalate exposure induces thyroid toxicity through follicular cell pyroptosis via the NRF2/KEAP1/NF-κB pathway.
Wang J, Fu F, Chen Y, Fu K, Luo H, Yang J, Ruan H
Annals of medicine 2026 Dec;58(1):2643496
Annals of medicine 2026 Dec;58(1):2643496
Fisetin alleviates lipopolysaccharide-induced mastitis by inhibiting ferroptosis and modulating the gut microbiota.
Tong C, Wang L, Wen H, Yao X, Tong J, Zhang R, Li X, Xiang Y, Wang X
The veterinary quarterly 2026 Dec;46(1):2642789
The veterinary quarterly 2026 Dec;46(1):2642789
EGCG-loaded nanoparticles attenuate post-SAH white matter injury by targeting HO-1/S100A10 to suppress oxidative stress-induced reactive astrocytes.
Lang D, Zheng Y, Zhang J, Li Z, Niu M, Wang J, Wang X, Huang L, Xue J, Li L, Chen Y
Redox report : communications in free radical research 2026 Dec 31;31(1):2664955
Redox report : communications in free radical research 2026 Dec 31;31(1):2664955
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury.
Lin W, Dong C, Jiang Q, Lou Y, Wang L, He Z
Redox report : communications in free radical research 2026 Dec 31;31(1):2657075
Redox report : communications in free radical research 2026 Dec 31;31(1):2657075
A coenzyme-based "interface-welding" hydrogel coating for titanium implants promotes diabetic osseointegration by regulating mitochondrial dynamics.
Duan Q, Geng W, He T, Yang J, Li K, Yang F, Fu Z, Liao X, Luo H, Zhao P, Cai K
Biomaterials 2026 Aug;331:124115
Biomaterials 2026 Aug;331:124115
Modified Erxian Decoction ameliorates premature ovarian insufficiency via HIF-1α-mediated regulation of mitochondrial fission and oxidative stress.
Deng D, Zeng Z, Feng J, Guo J
Journal of ethnopharmacology 2026 Aug 10;367:121768
Journal of ethnopharmacology 2026 Aug 10;367:121768
Resveratrol Attenuates Neuroinflammation and Myelination Deficits in Repeated Sevoflurane-Exposed Neonatal Mice.
Che J, Wu Y, Dong J, Shi C, Chen Y, He Z, Zhang X, Zhang J
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2026 Apr;86(2):e70123
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2026 Apr;86(2):e70123
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activation of the Sirt1/Nrf2/FOXO3 Signaling Pathway.
Xu J, Wan W, Mu H, Gong S, Liu Y, Deng T
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70813
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70813
Puerarin attenuates myocardial ischemia‑reperfusion injury by inhibiting myocardium pyroptosis via the NRF2/HO‑1 signaling pathway.
Zheng X, Li J, Hu T, Tan L, Lan D, Deng Y
Molecular medicine reports 2026 Apr;33(4)
Molecular medicine reports 2026 Apr;33(4)
Pinobanksin alleviates 4℃ semen preservation-induced oxidative damage and apoptosis in Wenchang Pig spermatozoa via the CaMKKβ/AMPK/Nrf2 pathway.
Yang D, He S, Tian X, Cheng C, Fan W, Peng H
Veterinary journal (London, England : 1997) 2026 Apr;316:106599
Veterinary journal (London, England : 1997) 2026 Apr;316:106599
The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis.
Lv X, He Z, Xue J, Yang Y, Tang Y, Cai H, Luo H, Li X, Dong Z, Liu Y, Zeng J, Yang Z, Cheng P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157999
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157999
Resveratrol dual efficacy in high-altitude hypoxia and NAFLD: inhibits ferroptosis by modulating key proteins, including HIF-1α, ACSL4, and TfR1.
Zhao M, Mu H, Ji Q, Song J, Zheng F, Liu T, Li W, Wang R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157992
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157992
Engineered Mesenchymal Stem Cells with Endogenous Trehalose Expression Activate the NRF2-HMOX1 Pathway to Enhance Antioxidant Stress and Wound Healing Capacity.
Wang Z, Liu X, Chen X, Jing J, Chen Q, Zhou F, Chen Z, Fang W, Wang L, Wang Y, Li Z, Wang Q, Gao J, Zhao J, Xu G, Pang R
Advances in wound care 2026 Apr 8;:21621918261438590
Advances in wound care 2026 Apr 8;:21621918261438590
Computational-experimental integration reveals PPARγ/Nrf2-GPX4 dual-targeting by combined selenomethionine-magnolol as a novel therapy for sarcopenic obesity.
Li Z, Liu B, Zhou L, Chen N, Wang Y, Yang S, Fan X, Wang Y, Chen X
Free radical biology & medicine 2026 Apr 7;251:243-255
Free radical biology & medicine 2026 Apr 7;251:243-255
Selective Radioprotection by the Fusion Antioxidant Enzyme GS1XR Via an MMP-2/9-Cleavable Cell-Penetrating Switch.
He H, Chu J, Lin L, Lu L, Li C, Han Y, Pan J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71768
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71768
Aerobic Exercise Alleviates Oxidative Stress and Inflammation to Attenuate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in ApoE(-/-) Mice.
Zhang L, Wang W, Zheng F, Weng J, Lu Y, Li Q, Li T, Li W, Wang L
Metabolites 2026 Apr 21;16(4)
Metabolites 2026 Apr 21;16(4)
The curcumin derivative DMC-GF promotes ferroptosis through the Nrf2/HMOX1 pathway, increasing glioma susceptibility to temozolomide.
Tao H, Li X, Han Z, Wang Z
Scientific reports 2026 Apr 18;
Scientific reports 2026 Apr 18;
Discovery of novel Keap1-targeting hydrophobic tag (HyT) tethering degraders with potent Nrf2 activation activity.
Li Z, Liu M, Zhao H, Zhang W, Wang L, Zhang Y, Xu J, Shen T, Ren D, Wang X
European journal of medicinal chemistry 2026 Apr 15;308:118700
European journal of medicinal chemistry 2026 Apr 15;308:118700
Macrophage-Targeted Nanocarriers Based on Tetrahedral DNA Nanostructure Alleviate Sepsis-Induced Acute Lung Injury by Triple-Pathway Suppression of Pyroptosis.
Zhang Y, Pan M, Ma F, He C, Gu Q, Wang Y, Pan Z, Wang H, Yan Y, Fu X, Jia Y, Duan H, Wu Y, Wei Z, Wang J, Li B, Liao Y, Zhan L
ACS applied materials & interfaces 2026 Apr 15;18(14):20128-20145
ACS applied materials & interfaces 2026 Apr 15;18(14):20128-20145
Notopterol attenuates atherosclerosis by promoting macrophage cholesterol efflux via targeting KEAP1/NRF2 interaction.
Qin Y, Meng J, Chen Y, Zhang W, Yi J, Wang S
International immunopharmacology 2026 Apr 15;175:116404
International immunopharmacology 2026 Apr 15;175:116404
Heme oxygenase-1-enriched tolerogenic dendritic cell-derived exosomes attenuate lupus nephritis by restoring immune balance and iron homeostasis.
Xing Z, Yang J, Zhang H, Xie Y, Yang Q, Wu M, Wang W, Gao S, Hua C
Free radical biology & medicine 2026 Apr 10;251:60-74
Free radical biology & medicine 2026 Apr 10;251:60-74
Egg white-derived metabolic regulatory peptide AD-IR10 promotes diabetic wound healing via Keap1/Nrf2/Irg1-mediated macrophage metabolic reprogramming.
Sun D, Su T, Niu X, He Y, Wang X, Sumampouw F, Wu C, Lu F, Chang Q, Dong Z
Free radical biology & medicine 2026 Apr 1;251:118-136
Free radical biology & medicine 2026 Apr 1;251:118-136
Astaxanthin ameliorates allergic rhinitis via suppression of the HMGB1/TLR4 signaling pathway.
Lei X, Pan J, Deng K
Central-European journal of immunology 2025;50(3):276-289
Central-European journal of immunology 2025;50(3):276-289
Green coffee bean extract rich in chlorogenic acids prevents muscle capillary regression via inhibiting oxidative stress and enhancing angiogenesis.
Xing J, Lin H, Nakanishi R, Iwai K, Maeshige N, Kondo H, Fujino H
Biomedical research (Tokyo, Japan) 2025;46(1):15-25
Biomedical research (Tokyo, Japan) 2025;46(1):15-25
Corynoline alleviates renal ischemia-reperfusion injury by enhancing Nrf2/HO-1 pathway.
Chang M, Sichen B
Acta cirurgica brasileira 2025;40:e406825
Acta cirurgica brasileira 2025;40:e406825
Targeting Reactive Oxygen Species and Inflammation in Sepsis-Induced Liver Injury with Naturally Derived Superoxide Dismutase-Mimicking Carbon Dots.
Zhong C, Song N, Huang P, Han L, Zhang J, Lu Z, Wang L
Biomaterials research 2025;29:0249
Biomaterials research 2025;29:0249
Temporal dynamics of ferroptosis markers and neuroprotective intervention in cerebral ischemia-reperfusion injury: Insights for therapeutic strategy development.
Bao S, Liu C, Wang QW, Zhang C, Zhao H
Iranian journal of basic medical sciences 2025;28(12):1699-1705
Iranian journal of basic medical sciences 2025;28(12):1699-1705
Imbalance of Bone Homeostasis Caused by Nrf2 Deficiency Leads to Bone Loss in OVX Rats.
Sun P, Wang Z, Chen S, Chen X, Zhou F, Zhang C, Yang J, Huang Y, Lin Y
Stem cells international 2025;2025:7214250
Stem cells international 2025;2025:7214250
Elucidating the Therapeutic Mechanism of Danggui Liuhuang Decoction in Hyperthyroid Kidney Disease: An Integration of Network Pharmacology and Metabolomics.
Jiang Y, Wang Z, Zhao Y, Yu Q, Weng L, Xiao C
International journal of endocrinology 2025;2025:5513418
International journal of endocrinology 2025;2025:5513418
Interaction of coexposure to inorganic arsenic and manganese: Tight junction injury of the blood-brain barrier and the relationship between oxidative stress and inflammatory cytokines in glial cells.
Hitomi T, Okuda H, Takata A, Yamauchi H
PloS one 2025;20(8):e0330287
PloS one 2025;20(8):e0330287
Human umbilical cord mesenchymal stem cell-derived exosomes mitigate acute radiation-induced intestinal oxidative damage via the Nrf2/HO-1/NQO1 signaling pathway.
Wang H, Wang J, Yang G, Li Y, Chen W, Yu J, Han X
PloS one 2025;20(6):e0324238
PloS one 2025;20(6):e0324238
Silencing NRF2 enhances arsenic trioxide-induced ferroptosis in hepatocellular carcinoma cells.
Huang M, Li D, Xia Z, Liao S, Si W, Yuan C, Liao Y, Wu W, Jiang M, Yu X, Quan Y
PloS one 2025;20(5):e0322746
PloS one 2025;20(5):e0322746
Protective effect of Pinacidil on hypoxic-reoxygenated cardiomyocytes in vitro and in vivo via HIF-1α/HRE pathway.
Wang Y, Wang J, Chen L, Zhou W, He H, Chen X, Wang H
PloS one 2025;20(2):e0318859
PloS one 2025;20(2):e0318859
Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury.
Chen W, Zhang Y, Chen J, Dong S, Wu X, Wu Y, Du Z, Yang Y, Gong L, Yu J
International journal of nanomedicine 2025;20:5039-5057
International journal of nanomedicine 2025;20:5039-5057
Asiaticoside Attenuates Chronic Restraint Stress-Induced Hippocampal CA1 Neuronal Ferroptosis via Activating BDNF/Nrf2/GPX4 Signaling Pathway.
Zhou A, Feng HY, Fan CN, Wang J, Yuan ZY, Xu GH, Li CF, Huang WF, Yi LT
Drug design, development and therapy 2025;19:793-810
Drug design, development and therapy 2025;19:793-810
Magnesium Isoglycyrrhizinate Alleviates Alectinib-Induced Hepatotoxicity by Inhibiting Mitochondrial Damage-Mediated Pyroptosis.
Chen Y, Wang C, Wu Y, Zeng Y, Xie S, Weng J, Guo L, Fu J, Zhou T, Zhang X, Zhou Z
Drug design, development and therapy 2025;19:6219-6233
Drug design, development and therapy 2025;19:6219-6233
Sakuranetin Prevents Acetaminophen-Induced Liver Injury via Nrf2-Induced Inhibition of Hepatocyte Ferroptosis.
Long Z, Yu X, Li S, Cheng N, Huo C, Zhang X, Wang S
Drug design, development and therapy 2025;19:159-171
Drug design, development and therapy 2025;19:159-171
Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis.
Wang FF, Li R, Liao D, Liu CQ, Yang XL
International journal of ophthalmology 2025;18(6):978-985
International journal of ophthalmology 2025;18(6):978-985
IGF2BP1 Enhances Neprilysin mRNA Stability to Promote Proliferation, Invasion, and Angiogenesis in Placental Trophoblasts.
Fan C, Zhou H, Pan Y, Lu D
International journal of general medicine 2025;18:967-980
International journal of general medicine 2025;18:967-980
Subchronic Chlorpyrifos Exposure Induces Thyroid Follicular Cell Pyroptosis to Exacerbate Thyroid Toxicity by Modulating Nrf2/Keap1/NF-κB Pathway in Male Mice.
Gu B, Chen Y, Xu H, Zhan K, Zhu K, Luo H, Huang Y, Zeng H, Zheng W, Tian K, Ruan H
Journal of inflammation research 2025;18:9307-9320
Journal of inflammation research 2025;18:9307-9320
Astragaloside IV Attenuates Chronic Prostatitis by Activating Keap1/Nrf2/HO-1 Pathway: Suppressing Ferroptosis and Enhancing Antioxidant Defense.
Shi J, Xuan Y, Zhang Q, Chen J, Zhu W, Zhang H, Duan Y
Journal of inflammation research 2025;18:10061-10079
Journal of inflammation research 2025;18:10061-10079
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway.
Wang Y, Ji X, Wang X, Sun M, Li C, Wu D
Journal of inflammation research 2025;18:1-15
Journal of inflammation research 2025;18:1-15
Curculigoside alleviates ferroptosis in renal interstitial fibrosis by regulating the Nrf2/HO-1 signaling pathway.
Liu T, Sui M, Yu C, Bao Y, Xing L, Hou D, Xie R
American journal of translational research 2025;17(10):7640-7658
American journal of translational research 2025;17(10):7640-7658
Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice.
Luo S, Lan Y, Zhang R, Luan Z
Frontiers in pharmacology 2025;16:1737091
Frontiers in pharmacology 2025;16:1737091
Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury.
Xie S, Liu M, Chen L, Xie Y, Liu L, Chen W, Huang H
Frontiers in pharmacology 2025;16:1690067
Frontiers in pharmacology 2025;16:1690067
Coreopsis tinctoria Nutt. attenuates ultraviolet A photodamage by suppressing endoplasmic reticulum stress-induced apoptosis via Nrf2 crosstalk.
Liang L, Nie X, Zhao N, Li M, Li M, Li Z, Wu M, Wu X, Lee CL, Shu P, Zhong J
Frontiers in pharmacology 2025;16:1686234
Frontiers in pharmacology 2025;16:1686234
Exploring the mechanism of Qingre Yishen Xiaozheng formula in treating diabetic kidney disease via the HIF-1α/HO-1 signaling pathway: an integrated network pharmacology and experimental study.
Han F, Shou J, Wang Y, Tian Z, Zheng H, Liu L, Liu W
Frontiers in pharmacology 2025;16:1661050
Frontiers in pharmacology 2025;16:1661050
Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of acteoside in the treatment of diabetic nephropathy.
Luo Z, Zhang SJ, Tang JY, Deng Y, Kang Y, Zhang XH, Lu HM, Wang YX, Liu WJ, Ma Y
Frontiers in pharmacology 2025;16:1660227
Frontiers in pharmacology 2025;16:1660227
Jianpi-Huayu-Jiedu formula improves metabolic dysfunction-associated steatohepatitis through ameliorateing hepatic oxidative stress and lipid accumulation in vivo and in vitro.
Wu X, Chen T, Zhang Z, Wang D, Zhou K, Li J, Xu L, Meng C, Pan H, Huang J, Gao Y, Li S
Frontiers in pharmacology 2025;16:1612726
Frontiers in pharmacology 2025;16:1612726
Polygala tenuifolia Willd. Extract delays non-alcoholic fatty liver disease progression in rats via the COX2 and PERK-elF2α-ATF4 pathway.
Sun Z, Zhou Z, Liao K, Liu Y, Liu Y, Wang C, Zhang Z, Wen L
Frontiers in pharmacology 2025;16:1595752
Frontiers in pharmacology 2025;16:1595752
Ursolic acid drug-drug nanocrystals ameliorate cholestatic liver injury via inhibiting oxidative stress and regulating bile acid metabolism.
Hu M, Hua X, Xiong W, Zheng E, Yang X, Lu Y, He B, Zhong X, Jiang Z, Zhang Q, Liu Y
Frontiers in pharmacology 2025;16:1586141
Frontiers in pharmacology 2025;16:1586141
Langqing Meiduo Jiujie pills treatment attenuates acute liver injury in animals by regulating anti-oxidative stress and liver metabolism.
Wang Z, Wang F, Huang Y, Zhaxi G, Fu J, Song G, Bai B, Han M, Zhang J, Li Y, Li R, Zhang T, Nhamdriel T, Zeweng Y, Ganghuan C, Wang Z
Frontiers in pharmacology 2025;16:1582435
Frontiers in pharmacology 2025;16:1582435
Thymoquinone alleviates the accumulation of ROS and pyroptosis and promotes perforator skin flap survival through SIRT1/NF-κB pathway.
Yang J, Zhang H, Ni L, He J
Frontiers in pharmacology 2025;16:1567762
Frontiers in pharmacology 2025;16:1567762
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway.
Li H, Gao Y, Huang M, Zhang H, Wu Q, Huang Y, Ye X, Chen W
Frontiers in pharmacology 2025;16:1557681
Frontiers in pharmacology 2025;16:1557681
Synthesis, target analysis, and cerebroprotective effects of novel imide antioxidants via the Nrf2/HO-1 pathway in cerebral ischemia-reperfusion injury.
Huang L, Chen Y, Zhou H, Chen H, Wu X, Wu Z, Liu Z, Zheng Z
Frontiers in pharmacology 2025;16:1552717
Frontiers in pharmacology 2025;16:1552717
Magnolia kobus DC. Alleviates adenine-induced chronic kidney disease by regulating ferroptosis in C57BL/6 mice.
Kim JM, Kim Y, Na HJ, Hur HJ, Lee SH, Sung MJ
Frontiers in pharmacology 2025;16:1548660
Frontiers in pharmacology 2025;16:1548660
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Yan Y, Fang M, Zhao C, Lin X, Tong C, Xiang C, Ran Y, Wang X, Li S, Chen G, Fu L
Frontiers in pharmacology 2025;16:1542296
Frontiers in pharmacology 2025;16:1542296
Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the Keap1/Nrf2/HO-1 pathway.
Su J, Zhang Y, Wang X, Hu X, Zhou K, Zhu H, Liu E, Liu S
Frontiers in pharmacology 2025;16:1535352
Frontiers in pharmacology 2025;16:1535352
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Zhu Z, Huang Z, Zhang C, Xu B, Chen H, Pei S, Zhang B, Jie L, Shi X, Liu Y, Li Y, Shen X
Frontiers in pharmacology 2025;16:1501725
Frontiers in pharmacology 2025;16:1501725
A multifunctional injectable microsphere with enhanced near-infrared photo-antibacterial, ROS scavenging, and anti-inflammatory properties for periodontitis treatment.
Xiu Z, Zhu Y, Li X, Jiang X, Feng Y, He L, Li C, Cai R, Tao G
Theranostics 2025;15(9):3750-3780
Theranostics 2025;15(9):3750-3780
Securinine, a novel alkaloid, regulates cell cycle and EMT in gastric cancer by inducing iron-dependent cell death.
Yuan W, Song H, Shi Y, Han J, Jiao S, Liang S, Xu Y, Jiang Y, Ji Y, Chen Z, Liu L, Xu A, Xu Z
Frontiers in oncology 2025;15:1599680
Frontiers in oncology 2025;15:1599680
Flufenamic acid inhibits pyroptosis in ischemic flaps via the AMPK-TRPML1-Calcineurin signaling pathway.
Chen L, Yang N, Chen K, Huang Y, Liu X, Yu G, Wang F, Gou Y, Wang Y, Lu X, Wang Y, Zhu L, Gao W, Ding J
Burns & trauma 2025;13:tkaf007
Burns & trauma 2025;13:tkaf007
Novel idebenone derivatives attenuated oxidative stress injury and myocardial damage.
Peng Y, Guo Y, Yang X, Liu Y, Xu X, Chen J, Liu X, Xie Z, Yu Z, Wu D, Chen Z
Frontiers in chemistry 2025;13:1544616
Frontiers in chemistry 2025;13:1544616
Injectable exosome-reinforced konjac glucomannan composite hydrogel for repairing cartilage defect: activation of endogenous antioxidant pathways.
Ye C, Xu J, Wang Y, Ji M, Tao R, Han F, Zhou P
Regenerative biomaterials 2025;12:rbaf060
Regenerative biomaterials 2025;12:rbaf060
Enhanced prevention on postoperative atrial fibrillation by using anti-inflammatory biodegradable drug patch.
Yu P, Lu W, Sun H, Huang C, Zhou X, Wang Y, Zhang Z, Fu G, Liu H, Ren K, Sheng X
Regenerative biomaterials 2025;12:rbaf040
Regenerative biomaterials 2025;12:rbaf040
Garlic oil-loaded nanodisks for the amelioration of acute lung injury via modulation of the NF-κB and Keap1-Nrf2 axis.
Hou R, Jiang B, Wang K, Yang X, Zhang W
Frontiers in molecular biosciences 2025;12:1686436
Frontiers in molecular biosciences 2025;12:1686436
Protosappanin A protects against pathological cardiac hypertrophy by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis via activation of the Nrf2 signaling pathway.
He Q, Zheng Y, Yan X, Lv S, Yu B
Frontiers in cardiovascular medicine 2025;12:1682641
Frontiers in cardiovascular medicine 2025;12:1682641
Comparative hepatoprotective effects of AMK and PAMK via Nrf2 signaling in broiler breeders.
Lu B, He J, Pan S, Wei J, Li B, Cao N, Huang Y, Tian Y, Cheong N, Chen Y, Xu D, Li W
Frontiers in veterinary science 2025;12:1672417
Frontiers in veterinary science 2025;12:1672417
Phytochemical nanozymes reprogram redox for balanced antimicrobial and regenerative therapy in acute and chronic diabetic wounds.
Pang Y, Amona FM, Chen X, You Y, Sha Z, Liu Z, Li J, Liu Y, Fang X, Chen X
Redox biology 2025 Sep;85:103718
Redox biology 2025 Sep;85:103718
Discovery of active compounds in Danshen-Chuanxiong formula for blood-brain barrier protection: a multi-parametric study using an OGD/R-induced spheroid model.
Zhou Y, Li Y, Yang Z, Zhao L, Wang Y
Journal of natural medicines 2025 Sep;79(5):1122-1139
Journal of natural medicines 2025 Sep;79(5):1122-1139
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Yan Y, Huang Z, Cheng L, Zhao S, Gao H, Chen K, Huang F, Mou L, Chen G, Fu L, Xu G
Toxicology and applied pharmacology 2025 Sep;502:117424
Toxicology and applied pharmacology 2025 Sep;502:117424
Uric Acid Stimulates PINK1/Parkin-Mediated Mitophagy via Nrf2/HO-1 Pathway to Protect Against Neuronal Apoptosis in Alzheimer's Disease.
Zhang Q, Xie D, Chen B, Yu L, Chen J, Yan Y, Zhang M, Wang Q, Xi Y, Yamamoto T, Koyama H, Cheng J
Antioxidants & redox signaling 2025 Sep;43(7-9):381-399
Antioxidants & redox signaling 2025 Sep;43(7-9):381-399
Hinokitiol Protects RPE cells from Oxidative and Autophagic Dysfunction: Implications for AMD Therapy.
Huang KC, Chiang YF, Wang KL, Huang YJ, Shieh TM, Ali M, Hsia SM
Free radical biology & medicine 2025 Sep;237:76-87
Free radical biology & medicine 2025 Sep;237:76-87
Oxidative stress-induced decreased expression of FABP5 leads to mitochondrial damage and survival disorder of decidual stromal cells in women with recurrent spontaneous abortion.
Li D, Duan H, Jiang Z, Zhou C, Cao C, Ni M, He L, Zhu X, Jin L, Liu W, Gu L, Li H, Liu D, Zhao X, Zhao G, Li J
Free radical biology & medicine 2025 Sep;237:270-284
Free radical biology & medicine 2025 Sep;237:270-284
Placental Ferroptosis May Be Involved in Prenatal Arsenic Exposure Induced Cognitive Impairment in Offspring.
Li M, Hu Y, Wu X, Tong J, Tao J, Tang A, Ji Y, Yao Y, Tao F, Liang C
Biological trace element research 2025 Sep;203(9):4543-4560
Biological trace element research 2025 Sep;203(9):4543-4560
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
Shen L, Xu J, Wang Y, Yao J, He X
Fitoterapia 2025 Sep;185:106688
Fitoterapia 2025 Sep;185:106688
An SPR-based active ingredient recognition strategy for identifying PLK1-targeting withanolides as natural ferroptosis inducers.
Zhu R, Yan H, Xu W, Liang J, Xiang K, Liu Y, Yang Y, Li H, Chen L
Bioorganic chemistry 2025 Sep;164:108849
Bioorganic chemistry 2025 Sep;164:108849
Design, synthesis and anti-gastric cancer activity of stable Bisamide curcumin analogues.
Wu J, Wang B, Gan X, Wu Y, Wu Y, Liu X, Hu R, Xie L, Bai H, Jin M, Fang B, Khushafah F, Wei T, Li W
Bioorganic chemistry 2025 Sep;164:108793
Bioorganic chemistry 2025 Sep;164:108793
β-elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting N6AMT1.
Lan J, Zhang W, Zeng K, Li C, He J, Li X, Yang R, Chi J, Hong Z, Wang W, Zhou C, Xiao B, Fan W, Lin J, Ou Q, Fang Y, Pan Z, Peng J, Li W, Wu X
Clinical and translational medicine 2025 Sep;15(9):e70438
Clinical and translational medicine 2025 Sep;15(9):e70438
Tectorigenin attenuates myocardial damage by doxorubicin-induced ferroptosis by activating the p62-Keap1-Nrf2/HO-1/GPX4 axis.
Xie L, Xiao S, Zhou Q, Chen W, Hu Z, Li Y, Liu Y, Ma X, Li Y
Journal of traditional and complementary medicine 2025 Sep;15(5):573-581
Journal of traditional and complementary medicine 2025 Sep;15(5):573-581
Breviscapine injection and its main component scutellarin prevents lethal enterovirus infection by inhibiting neuroinflammation and oxidative stress in newborn mice.
Yang W, Wang J, Tao Y, Li X, Tao S, Zhu H, Chen X, Shan J, Li Y, Ma T, Cao P, Cui G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157042
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157042
Dendrobium huoshanense improves atherosclerosis in high-fat-induced ApoE mice by regulating gut microbiota and serum metabolite profiles.
Zheng SJ, Gao XY, Diao XH, Chen ND
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156964
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156964
Inhibition of Iron Death by Lycium barbarum Polysaccharides Ameliorates Myocardial Injury in Sepsis: A Pharmacological Mechanism Study Based on the NRF2/HO-1 Pathway.
Niu Z, Hu Y, Yang L, Meng X, Chen M, Bai X, Liu R, Tang Y, Yang L, Xue W
Food science & nutrition 2025 Sep;13(9):e70835
Food science & nutrition 2025 Sep;13(9):e70835
Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]-humanin-mediated attenuation of oxidative stress and ferroptosis.
Liu Y, Feng Q, Zou L, Zhu C, Xia W
Andrology 2025 Sep;13(6):1541-1555
Andrology 2025 Sep;13(6):1541-1555
Kaempferol Plays a Neuroprotection Role by Alleviating Oxidative Stress via AKT/Nrf2/HO-1 Pathway and Inhibiting Apoptosis in Intracerebral Hemorrhage.
Huo H, Zhang A, Shi Y, Zhuo Y, Nan C, Yan D, Liu L
Neurochemical research 2025 Sep 6;50(5):291
Neurochemical research 2025 Sep 6;50(5):291
α-Cyperone safeguards against cerebral ischaemia‒reperfusion injury through the activation of the Nrf2 signalling pathway.
Yu H, Chen Y, Qu T, Hang J, Huang X, Hu A, Wang T, Gao Y, Shao J, Li Y, Chen Y
European journal of pharmacology 2025 Sep 5;1002:177842
European journal of pharmacology 2025 Sep 5;1002:177842
Peripheral blood mesenchymal stem cells repair oxidative damage and apoptosis in an H(2)O(2)-induced vitiligo oxidative stress in vitro model via the IL-10-mediated PI3K/AKT pathway.
Yang RL, Yang YB, Wei HX, Zhang M, Yang K, Zhao YJ, Yan W, Yang Y, Zhang T
European journal of medical research 2025 Sep 30;30(1):919
European journal of medical research 2025 Sep 30;30(1):919
Soluble urokinase plasminogen activator receptor promotes endoplasmic reticulum stress and apoptosis susceptibility through RAGE in sepsis acute kidney injury.
Wang B, Wang J, Qi C, Gao C, Wang Y, Zan Y, Tan Y, Wu Z, Jiang J, Suo J, Zhang J, Peng Z
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):296
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):296
A Novel Function of Glycerol Kinase Alleviates LPS-Induced Inflammatory Responses by the p38/STAT3 Pathway and Mitigates ROS Generation in Kupffer Cells.
Li Y, Zhang X, Wang D, Fan G, Yang X
Antioxidants (Basel, Switzerland) 2025 Sep 26;14(10)
Antioxidants (Basel, Switzerland) 2025 Sep 26;14(10)
Duhuo jisheng decoction alleviates osteoarthritis progression by mitigating ferroptosis in chondrocytes via the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 axis.
Wu B, Yang Z, Duan J, Chen Z, Xiao J, Luo Z, Jian G, Wang H, Lu G
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120441
Self-assembled cyanidin-3-O-glucoside nanoparticles alleviate inflammation and ferroptosis induced by PRRSV infection.
Chen X, Pang Y, Amona FM, Liu Z, Wang F, Liang Y, Yang J, Zhang W, Fang X, Chen X
Journal of virology 2025 Sep 23;99(9):e0095425
Journal of virology 2025 Sep 23;99(9):e0095425
3-hydroxyanthranilic acid analog mitigates ischemia-reperfusion injury by inhibiting cardiomyocyte ferroptosis through the activation of Nrf2/HO-1/GPX4.
Yang HY, Liu ZY, Xu ZQ, Teng LS, Sheng XH, Zhang G, Zhang FS
International immunopharmacology 2025 Sep 23;162:115117
International immunopharmacology 2025 Sep 23;162:115117
Shikimic Acid Mitigates Deoxynivalenol-Induced Jejunal Barrier Injury in Mice via Activation of the Nrf-2/HO-1/NQO1 Pathway and Modulation of Gut Microbiota.
Su Y, Zheng B, Zhou C, Li M, Yuan Y, Wang H, Li B, Wu S, Wu Z, Zhao Y, Zhang W, Shu G
Antioxidants (Basel, Switzerland) 2025 Sep 23;14(10)
Antioxidants (Basel, Switzerland) 2025 Sep 23;14(10)
7,8-Dihydroxyflavone attenuates cisplatin-induced cardiomyocyte apoptosis and mitochondrial dysfunction via the p53/Nrf2 pathway.
Tian Z, Tan TT, Hu YW, Yao JT, Kang XT, Zhou JY, Jia DX, Li QL, Liang RJ, Zhao LM, Zhu H, Zhao J, Hang PZ
Toxicology and applied pharmacology 2025 Sep 22;505:117578
Toxicology and applied pharmacology 2025 Sep 22;505:117578
Sheng Mai San Mitigates Heat Stress-Induced Myocardial Injury by Coordinated Regulation of the Keap1-Nrf2-HO-1 and Stub1-HSF1 Signaling Pathways.
Dong J, Ma Q, Yang R, Zhang X, Hua Y, Ji P, Yao W, Yuan Z, Wei Y
Antioxidants (Basel, Switzerland) 2025 Sep 22;14(9)
Antioxidants (Basel, Switzerland) 2025 Sep 22;14(9)
Hydrogen Sulfide-Preconditioned Mesenchymal Stem Cells Attenuate Ferroptosis in Corneal Alkali Burn via the AMPK/Nrf2/HO-1 Pathway in an IL-10-Dependent Manner.
Chen M, Jiang Y, Yu H, Qi H, Li X, Wang J, Wang A, Li Z, Wang Q, Huang Y, Wang L
Investigative ophthalmology & visual science 2025 Sep 2;66(12):58
Investigative ophthalmology & visual science 2025 Sep 2;66(12):58
Dovitinib Ameliorates Inflammation-Related Diseases by Inhibiting Necroptosis and Ferroptosis.
Lin Y, Feng J, Zhao M, Zhang L, Li Y, Chen X, Lin C, Lin J, Lin Q, Li J, Wu L, Li L
ACS chemical biology 2025 Sep 19;20(9):2191-2203
ACS chemical biology 2025 Sep 19;20(9):2191-2203
Ovatodiolide triggers ferroptosis in high-grade serous ovarian cancer through HMOX1 upregulation.
Tzeng YM, Khine AA, Huang HS, Chu TY
Molecular therapy. Oncology 2025 Sep 18;33(3):201023
Molecular therapy. Oncology 2025 Sep 18;33(3):201023
Astaxanthin attenuates AFB1-induced hepatotoxicity by activating Nrf2 and inhibiting the NF-κB signaling pathway.
Kang K, Zhang Y, Xie W, Ma W, Chen J, Chen Z
Ecotoxicology and environmental safety 2025 Sep 15;303:119025
Ecotoxicology and environmental safety 2025 Sep 15;303:119025
Early-life glyphosate exposure impairs intestinal antioxidant status and induces growth retardation in post-hatched chicks.
Zhang M, Tian X, Liu X, Fan Y, Bian G, Deng K, Tang Q
Ecotoxicology and environmental safety 2025 Sep 15;303:118902
Ecotoxicology and environmental safety 2025 Sep 15;303:118902
Entospletinib alleviates acute liver injury and acute kidney injury by inhibiting ferroptosis.
Zhao M, Lin Y, Zeng Q, Li Y, Feng J, Chen X, Lin C, Zhang L, Zhong Y, Lin J, Lin Q, Li J, Wu L, Liu X, Li L
European journal of pharmacology 2025 Sep 15;1003:177939
European journal of pharmacology 2025 Sep 15;1003:177939
Transcription factor RUNX2 participates in astrocyte-mediated neuropathic pain via transcriptional activation of Ccl2.
Shen W, Song S, Zhao X, Li D, Liu J, Yue S
Biochemical and biophysical research communications 2025 Sep 1;777:152263
Biochemical and biophysical research communications 2025 Sep 1;777:152263
Nitrate Promotes the Survival of Diabetic Skin Flaps by Enhancing Autophagy Through the AMPK Signaling Pathway.
Li M, Zhu L, Xu Y, Han Z
The Journal of craniofacial surgery 2025 Sep 1;36(6):2127-2132
The Journal of craniofacial surgery 2025 Sep 1;36(6):2127-2132
Codonopsis pilosula polysaccharides attenuate lipid accumulation and inflammatory response in the NAFLD mouse by regulating AMPK/ACC/SREBP1 signaling pathway.
Chen Q, Lin H, Huang X, Yu W
Tissue & cell 2025 Oct;96:102984
Tissue & cell 2025 Oct;96:102984
Isoquercitrin mitigates intestinal ischemia-reperfusion injury by regulating intestinal flora and inhibiting NLRP3 inflammasome activation.
Xu H, He TQ, Chen SY, Shi RR, Xu J, Xing YR, Shi D, Liu YQ, He BS, Gu JH
Redox biology 2025 Oct;86:103803
Redox biology 2025 Oct;86:103803
Metal-phenolic encapsulation of carbon monoxide releasing molecule for enhanced gas therapy of periodontitis.
Liu C, Chen Y, Wang Y, Wang D, Sun J, Sun J, Ji L, Li K, Wang W, Zhao W, Song H, Li J
Materials today. Bio 2025 Oct;34:102213
Materials today. Bio 2025 Oct;34:102213
Construction and characteristics of an adjustable biomechanical in vitro corneal stromal model simulating keratoconus pathological features.
Li X, Li K, Gu J, Sun X, Liang Y, Ding C, Chen Y, Chen H, Chen J, Cui Z
Materials today. Bio 2025 Oct;34:102130
Materials today. Bio 2025 Oct;34:102130
The Matrine Derivative MASM Alleviates LPS-Induced Depressive-Like Behavior in Mice by Modulating Hippocampal Inflammation, Oxidative Stress, and Autophagy.
Li CR, Xu ZY, Sun LN, Wu LL, Zeng WF, Zhou J, Lian YJ, Wang Y, Wang YX
Alpha psychiatry 2025 Oct;26(5):47820
Alpha psychiatry 2025 Oct;26(5):47820
Berberine inhibits high glucose-induced ferroptosis in retinal vascular endothelial cells: Mechanism and implications.
Chen J, Peng W, Yang W, You Z, Zou Y
Experimental eye research 2025 Oct;259:110531
Experimental eye research 2025 Oct;259:110531
Oligodendrocyte-specific knockout of FPN1 affects CNS myelination defects and depression-like behavior in mice.
Zhang N, Zhang S, Liu X, Zuo YY, Cui YG, Wang F, Zhang JH, Chang YZ, Yu P
Free radical biology & medicine 2025 Oct;238:370-386
Free radical biology & medicine 2025 Oct;238:370-386
Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice.
Yu C, Cai L, Zhuang L, Wu Y, Wu Q, Liang H, Shi M, Miao J, Song H, Jin H, Pan Y
Free radical biology & medicine 2025 Oct;238:206-219
Free radical biology & medicine 2025 Oct;238:206-219
Hinokitiol modulates Nrf2/HO-1 signaling, autophagy, and URAT1 in hyperuricemia and oxidative stress models of renal injury.
Chiang YF, Huang KC, Huang YJ, Wang KL, Huang YJ, Shieh TM, Ali M, Hsia SM
Free radical biology & medicine 2025 Oct;238:169-178
Free radical biology & medicine 2025 Oct;238:169-178
Removal and toxic intervention of polystyrene microplastics and nanoplastics by magnetic nano-Fe(3)O(4) in spermatogonial GC-1 cells.
Cheng C, Cui Y, Wang Y, Huang J, Ma J, Luo T, Chen W
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109020
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109020
Shikonin Ameliorates Alcohol-Associated Liver Disease by Reducing Oxidative Stress, Apoptosis, and Inflammation.
Gan H, Gong M, Wang L, Huang X, Chen Y, Hu Z, Li X, Zeng Q
Food science & nutrition 2025 Oct;13(10):e71064
Food science & nutrition 2025 Oct;13(10):e71064
Protective Effects Proanthocyanidin Nanoliposome Freeze-Dried Powder on Oxidative Injury in a p31-43 Induced Celiac Disease Cell Model.
Ning Z, Linlin C, Xing Z, Kunmiao H, Tiantian X, Hanshuo W, Jie S, Miao Y, Hongtao R, Na W
Food science & nutrition 2025 Oct;13(10):e71000
Food science & nutrition 2025 Oct;13(10):e71000
Nanovesicles Synergistically Regulate Ferroptosis Characteristic Macrophage-Induced Angiogenesis via Ferritin Heavy Chain 1/Glutathione Peroxidase 4 Pathway to Promote Peripheral Nerve Regeneration.
Huo N, Xu G, Zhou H, Liu Y, Li S, Yang X, Liu J, Wang W, Yang N, Zhou N
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
ACS applied materials & interfaces 2025 Oct 8;17(40):55876-55894
Harpagide Confers Protection Against Acute Lung Injury Through Multi-Omics Dissection of Immune-Microenvironmental Crosstalk and Convergent Therapeutic Mechanisms.
Wang H, Yang J, Zhang Y, Wang J, Song S, Gao L, Liu M, Chen Z, Li X
Pharmaceuticals (Basel, Switzerland) 2025 Oct 4;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Oct 4;18(10)
Targeting PARK7: Sodium 4-Phenylbutyrate shields endothelial cells from oxidative stress and GSDME-mediated Pyroptosis in acute lung injury.
Xu J, Wei T, Wang Y, Zhang C, Chen X, Li Y, Song J, Mao W, Xu Q, Wu X, Song Y
International immunopharmacology 2025 Oct 30;164:115386
International immunopharmacology 2025 Oct 30;164:115386
Med20 regulates myelination in the peripheral nervous system by modulating ferroptosis of Schwann cells.
Yang W, Chen X, Yang C, Mao Y, Zhuang W, Xiao Y, Zhang X, Ou Z, Chen Y
Cell reports 2025 Oct 28;44(10):116448
Cell reports 2025 Oct 28;44(10):116448
Hmox1 expression indicates distinct injury phenotypes of proximal tubule cells in sepsis-associated acute kidney injury.
He Y, Zhang W, Li Z, Liu C, Peng Y
Scientific reports 2025 Oct 27;15(1):37372
Scientific reports 2025 Oct 27;15(1):37372
Neuroprotective Effects and Mechanisms of Arecoline Against H(2)O(2)-Induced Damage in SH-SY5Y Cells.
Zhang X, Cui J, Sun J, Wang F, Fan B, Lu C
International journal of molecular sciences 2025 Oct 24;26(21)
International journal of molecular sciences 2025 Oct 24;26(21)
Ginsenoside Ro Targets BCAT1/2 to Suppress Ferroptosis: A Novel Therapeutic Strategy for Ischemic Cardioprotection.
Liu J, Wang F, Bai J, Qu S, Tao S, Liu C, Wang Q, Ding W, Lai Q, Zhang J
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26683-26699
Journal of agricultural and food chemistry 2025 Oct 22;73(42):26683-26699
Vorapaxar enhanced mitochondria-associated ferroptosis primes cancer immunotherapy via targeting FOXO1/HMOX1 axis.
Zhou Q, Sun Y, Du S, Dian Y, Yao L, Su H, Guo Z, Meng Y, Xiong Y, Deng Z, Kuang X, Liang X, Liu H, Deng G, Chen X, Zeng F
Cell reports. Medicine 2025 Oct 21;6(10):102371
Cell reports. Medicine 2025 Oct 21;6(10):102371
Proanthocyanidins carbon dots inhibit PRRSV infection by activating Nrf2/ARE to regulate oxidative stress and NLRP3 inflammasome-mediated pyroptosis.
Wang F, Pan Z, Amona FM, Chen X, Pang Y, Liang Y, Lai M, Zhang C, Chen X, Fang X
Veterinary research 2025 Oct 16;56(1):197
Veterinary research 2025 Oct 16;56(1):197
Exocarpium Citri Grandis ameliorates alcoholic liver disease by modulation of hepatic lipid metabolism and iron homeostasis.
Li YJ, Zhang YX, Xu S, Qin MC, Deng GH, Li JJ, Shen XF, Guo H, Liao YX, Zhou CY, Huang SH, Liu MH, Zhao WX, Gao L
Chinese medicine 2025 Oct 16;20(1):174
Chinese medicine 2025 Oct 16;20(1):174
Integrated Multiomic Analysis Reveals the Therapeutic Potential of Danhong Injection in Mitigating Radiation-Induced Heart Disease by Modulating Ferroptosis.
Wang BW, Wang G, Zhang Z, Lu WJ, Li YL, Shu YB, Xie P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71106
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71106
Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.
Godoy-Lugo JA, Hicks D, Durra S, Massey ER, Shkirkova K, Sauri AI, Kerstiens E, Chen S, Zhao L, Sioutas C, Mack WJ, Finch CE, Thorwald MA
Environmental pollution (Barking, Essex : 1987) 2025 Oct 15;383:126845
Environmental pollution (Barking, Essex : 1987) 2025 Oct 15;383:126845
Design of spiro-heterocyclic substituted diaminonaphthalene Keap1-Nrf2 protein-protein interaction inhibitors as novel anti-depressant agents.
Chen Y, Qin Q, Ding W, Yu R, Wang R, Ji H, Yan J, Ma H, Jiang CS, Sun Y, Zhuang C
European journal of medicinal chemistry 2025 Oct 15;296:117848
European journal of medicinal chemistry 2025 Oct 15;296:117848
Isorhynchophylline alleviates preeclampsia via PI3K/AKT/mTOR-mediated trophoblast oxidative stress inhibition.
Wang J, Li X, Zhu Y, Zhang X, Ye C, Zhuang Q, Wang Z, Liu D, Zhao G
European journal of pharmacology 2025 Oct 15;1005:178076
European journal of pharmacology 2025 Oct 15;1005:178076
Fermentation of Panax ginseng C.A. Meyer extract with lactic acid bacteria exerts hepatoprotective effects via activating the NRF2 pathway.
Liang JJ, Liu HX, Yan JG, Xie G, Liu WL, Lin JH, Li XM, Mao XL
Journal of molecular histology 2025 Oct 14;56(6):343
Journal of molecular histology 2025 Oct 14;56(6):343
Research on the Protective Effects and Mechanisms of Gallic Acid Against Cognitive Impairment Induced by Chronic Sleep Deprivation.
Zhang X, Cui J, Sun J, Wang F, Fan B, Lu C
Nutrients 2025 Oct 12;17(20)
Nutrients 2025 Oct 12;17(20)
Cordycepin attenuated cyclophosphamide (CTX)-induced immunosuppression in mice via EGFR/Nrf2 antioxidant signaling pathway.
Zhong M, Feng M, Chen X, Zhang Y, Wang Y, Yuan P, Zhang T, Han Z, Tang C, Zhang Q, Sun Y
International immunopharmacology 2025 Oct 10;163:115235
International immunopharmacology 2025 Oct 10;163:115235
NFE2L2 protects against Sorafenib-induced Ferroptosis and cardiotoxicity by activating the HO1/ferritin pathway.
Jiang H, Su Y, Hou Y, Wang C
Toxicology and applied pharmacology 2025 Nov;504:117537
Toxicology and applied pharmacology 2025 Nov;504:117537
Carnosol attenuates Ang II-induced renal injury by p62-KEAP1-NRF2 signaling pathway.
Fan S, Zhao Y, Zhao Q, Xu D, Chen X, Han J, Fang Z, Liang G, Zhao Y
Toxicology and applied pharmacology 2025 Nov;504:117528
Toxicology and applied pharmacology 2025 Nov;504:117528
ML385 increases ferroptosis via inhibiting Nrf2/HO-1 pathway to enhances the sensitivity of MCF-7 TAMR to tamoxifen.
Yuan J, Huang W, Lin M, Sun S, Zhong F, Ye L, Yin H, Ou X, Zeng Z
Naunyn-Schmiedeberg's archives of pharmacology 2025 Nov;398(11):16081-16093
Naunyn-Schmiedeberg's archives of pharmacology 2025 Nov;398(11):16081-16093
Quercetin Targets HSP90α and Regulates Keap1/Nrf2 Pathway to Inhibit Crosstalk between Apoptosis and Ferroptosis in Oxidatively Stressed Neurons.
Liu J, Zhang ZZ, Yu GR, Han X
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70583
Astragaloside IV Alleviates Cisplatin Chemotherapy-Induced Nephrotoxicity via Modulation of Nrf2/HO-1/NF-κB Pathway and Reversal of EMT Process.
Ding X, Han X, Zhang Y, Zhang Y, Li F, Wang J
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70565
Journal of biochemical and molecular toxicology 2025 Nov;39(11):e70565
Preprotective Effects of Cardamomin From Amomum villosum Lour. on H(2)O(2) -Induced Oxidative Damage In Vitro and Cerebral Ischemic Stroke In Vivo.
Zhu M, Sun D, Wang H, Li Y, Li H, Chen L
Phytotherapy research : PTR 2025 Nov;39(11):5378-5390
Phytotherapy research : PTR 2025 Nov;39(11):5378-5390
Salvianolic Acid A Mitigates Osteoporotic Bone Loss by Repressing Reactive Oxygen Species via the Nrf2-HO-1 Pathway.
Qiu H, Cai C, Zhang Y, Yang S, Hu X, Chu T
Phytotherapy research : PTR 2025 Nov;39(11):4977-4990
Phytotherapy research : PTR 2025 Nov;39(11):4977-4990
Kaempferol prevents Nrf2 from ubiquitin-mediated proteolysis to mitigate both NLRP3 inflammation and oxidative stress: implications for alleviating DSS-induced colitis in mice.
Hua W, Li M, Yan Z, Wang Y, Zhou X, Fu Z, Wang Y, Zhang S, Qian J
Inflammopharmacology 2025 Nov;33(11):6861-6876
Inflammopharmacology 2025 Nov;33(11):6861-6876
Astragaloside IV: a natural shield against ochratoxin A-induced hepatotoxicity in chicks by targeting the NRF2/NLRP3 signaling pathway.
Yang J, Xu H, Ye R, Zhang Y, Wu J, Jin E, Li X, Cao M, Li S, Liu C, Li L
Toxicon : official journal of the International Society on Toxinology 2025 Nov;266:108513
Toxicon : official journal of the International Society on Toxinology 2025 Nov;266:108513
Salidroside improves bovine embryo quality by mitigating oxidative stress and regulating mitochondrial lipid metabolism.
Liu LY, Yu XF, Chi ZC, Shi SM, Lan T, Leng JH, Li JH, He YY, Qu LY, Jia GL, Kong I, Zhang MJ, Jin YX
Theriogenology 2025 Nov;247:117570
Theriogenology 2025 Nov;247:117570
Malic enzyme 1 reverses cardiomyocyte senescence in a nitric oxide-dependent manner.
Wu W, Lei R, Xu H, Lu L, Song C, Wu D, Li M, Chen L, Yu Y, Fang X
Free radical biology & medicine 2025 Nov;239:202-212
Free radical biology & medicine 2025 Nov;239:202-212
Fufang Huangqi Jianpi Oral Liquid alleviates spleen deficiency diarrhea via modulation of the NF-κB/Nrf2 signaling pathway and apoptosis.
Huang L, Qiu Z, Sun K, Yu C, Huang Q, Liu C, Pan X, Li S, Ge S, Shi X, Hu F, Xin R
3 Biotech 2025 Nov;15(11):377
3 Biotech 2025 Nov;15(11):377
Gut microbiota-bile acid metabolic disorder involved in the cognitive impairments in epilepsy through HO-1 dependent ferroptosis.
Li X, Ji J, Li J, Li S, Luo Q, Gu M, Yin X, Zhang M, Fan H, Yao R
Journal of pharmaceutical analysis 2025 Nov;15(11):101291
Journal of pharmaceutical analysis 2025 Nov;15(11):101291
CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway.
Chang X, Zhang Y, Wang Q, Yang W, Zhang R, Cong X, Xiao W, Piao J, Lin Z, Jin A
Cellular signalling 2025 Nov;135:111998
Cellular signalling 2025 Nov;135:111998
Epigallocatechin-3-Gallate Mitigates Atopic Dermatitis-Like Skin Lesions and Psychiatric Comorbidities by Reducing Oxidative Stress.
Tang L, Peng R, Guo J, Wang C, Wang T, Bao Y, He Y
Food science & nutrition 2025 Nov;13(11):e71248
Food science & nutrition 2025 Nov;13(11):e71248
Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia-Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling-Mediated Neutrophil Extracellular Traps Formation.
Tian H, Xiong Y, Zhan J, Lu Z, Zhang Y, Leng Y, Huang Q, Xia Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e09952
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e09952
Novel Role of Gut-Derived Roseburia Intestinalis in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure.
Zhou L, Wang C, Gao J, Wu X, Li G, Jiang X, Xia Y, Zhang J, Lv B, Zhao F, Zhang H, Pi H, Qiu J, Xu S, Zou Z, Chen C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e11895
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e11895
Dexmedetomidine alleviates ferroptosis caused by traumatic brain injury via the NRF2/HO-1/GPX4 pathway.
Hao JJ, Fang XL, Chen YY, Meng ZJ, Dong FX, Yang XF, Chu Z, Kuai JX, Bao H
Metabolic brain disease 2025 Nov 5;40(8):306
Metabolic brain disease 2025 Nov 5;40(8):306
Curcumin induces ferroptosis in hepatocellular carcinoma by regulating the P62-KEAP1-NRF2-signaling pathway.
Deng J, Wu Z, Ning S, Chang X, Liu J, Yu Y, Zhang M, Zhang L
BMC cancer 2025 Nov 29;26(1):90
BMC cancer 2025 Nov 29;26(1):90
Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1.
Zhang GY, Zhang F, Xie LP, Han X, Wang ZX, Wang WL, Peng Y, Xu HL, Xu T, Pang MJ, Liu B, Wang D, Zhou YC, Wu YT
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1726-1741
The Journal of pharmacy and pharmacology 2025 Nov 28;77(12):1726-1741
Saponins from Dioscorea nipponinca Makino rehabilitate UVB-induced skin photoaging by inhibiting oxidative stress and apoptosis via targeting STAT3.
Cai Q, Zhang Q, Zhang Y, Xue X, Han L, Peng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157452
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157452
Quercetin ameliorates doxorubicin-induced atrial fibrillation via EGFR-mediated restoration of autophagic flux.
Bian WH, Wang SH, Kang ZC, Xu Y, Li YN, Yang MZ, Yang JH, Liu JY, Cheng YL, Chang D, Xie X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157357
Mechanism and potential targets of kaempferol alleviating photothrombotic stroke via integrating experimental validation, network pharmacology, and molecular docking.
Liu M, Liu DN, Shang YF, Zhang WF, Feng WD, Fang LH, Du GH, Wang YH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157354
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157354
Gastrodin Injection Relieves Hypoxic-Ischemic Brain Injury in Newborn Rats by Regulating the P62/Nrf2/HO-1 Pathway.
Wu S, Ren Z, Yang M, Xiong Y, Li X, Wu X, Xu J, Chen M
Molecular neurobiology 2025 Nov 24;63(1):150
Molecular neurobiology 2025 Nov 24;63(1):150
IL-22 attenuates MAFLD progression by modulating oxidative stress and ferroptosis.
Li S, Zhang Y, Li P, Xue X, Huo L
Scientific reports 2025 Nov 23;15(1):45166
Scientific reports 2025 Nov 23;15(1):45166
Nrf2-ARE signaling pathway-mediated protection in rat models of intracerebral hemorrhage with different volumes.
Liu Y, Zhang W, Qing Q, Mei Q, Liu Z, Lu L
Metabolic brain disease 2025 Nov 20;40(8):321
Metabolic brain disease 2025 Nov 20;40(8):321
Rescuing fertility: C-Phycocyanin prevents ovarian damage through NRF2-mediated ferroptosis pathways in polycystic ovary syndrome models.
Zhang J, Shen QS, Chen YX, Cheng HR, Zhang W, Xing T, Liu YJ, Cao YX, Liang D, Luo M, Yu B
Zoological research 2025 Nov 18;46(6):1531-1548
Zoological research 2025 Nov 18;46(6):1531-1548
5-Hydroxymethylfurfural Alleviates Lipopolysaccharide-Induced Depression-like Behaviors by Suppressing Hypothalamic Oxidative Stress and Regulating Neuroinflammation in Mice.
Ya B, Yin H, Yuan L, Jing A, Li Y, Yan F, Zhang H, Xiong H, Zhao M
Antioxidants (Basel, Switzerland) 2025 Nov 17;14(11)
Antioxidants (Basel, Switzerland) 2025 Nov 17;14(11)
Effects of fasudil against photothrombotic stroke in genetically modified obese (ob/ob) mice.
Salman M, Shahzad H, Bhattacharya SK, Gangaraju R, Brown CM, Ishrat T
Metabolic brain disease 2025 Nov 15;40(8):315
Metabolic brain disease 2025 Nov 15;40(8):315
Sotagliflozin attenuates atrial oxidative stress and the susceptibility to atrial fibrillation by activating the NRF2/HO-1 pathway.
Li F, Xie M, Zeng G, Zhu J, Zhou J, Tan S, Lin Q, Liu Q
International immunopharmacology 2025 Nov 14;165:115461
International immunopharmacology 2025 Nov 14;165:115461
Design of anti-depressant phosphodiester amino acidic Keap1-Nrf2 protein-protein interaction inhibitors.
Sun Y, Wang J, Ding W, Qin Q, Wang R, Yu R, Yan J, Hou R, Liu G, Cai X, Qu Z, Zhang W, Yu J, Xing C, Zhuang C
Redox biology 2025 May;82:103620
Redox biology 2025 May;82:103620
Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis.
Wang J, Song Y, Tan X, Wang T, Shi Y, Xu X, Du J, Yu Z, Song B
Redox biology 2025 May;82:103619
Redox biology 2025 May;82:103619
Ursonic Acid Ameliorates H(2)O(2)-Induced Oxidative Damage in PC12 Cells and Prolonged the Lifespan in C. elegans by Activating MAPKs/Nrf2/HO-1 Signaling Pathway.
Wang J, Yang J, Lu J, Lu J, Ling B, Song Y, Chen G
Molecular neurobiology 2025 May;62(5):6598-6611
Molecular neurobiology 2025 May;62(5):6598-6611
Therapeutic effect of edaravone on osteoarthritis: targeting NRF2 signaling and mitochondrial function.
Jiang C, Gong Y, Wu X, Chen J, Chen Y, Chen J, Tang F, Fang Z, Bao Y, Ye J, Wang Z, Hong Z
Journal of orthopaedic translation 2025 May;52:220-232
Journal of orthopaedic translation 2025 May;52:220-232
Brigatinib activates inflammasomes: Implication for immune-related adverse events.
Noda T, Tanaka S, Maruta Y, Haruna M, Mizuguchi S, Fujimoto A, Urashima K, Kohda Y, Kato R
Toxicology and applied pharmacology 2025 May;498:117310
Toxicology and applied pharmacology 2025 May;498:117310
Endothelial Gsα deficiency promotes ferroptosis and exacerbates atherosclerosis in apolipoprotein E-deficient mice via the inhibition of NRF2 signaling.
He LF, Wang L, Li JW, Xiong X, Yue XL, Yuan PD, Lu HL, Gao JG, Yu FP, Chen M, Weinstein LS, Yang JM, Zhang C, Qin X, Zhang W
Acta pharmacologica Sinica 2025 May;46(5):1289-1302
Acta pharmacologica Sinica 2025 May;46(5):1289-1302
Nuclear Factor Erythroid 2-Related Factor 2 Activator DDO-1039 Ameliorates Podocyte Injury in Diabetic Kidney Disease via Suppressing Oxidative Stress, Inflammation, and Ferroptosis.
Liu X, Zhai X, Wang X, Zhu X, Wang Z, Jiang Z, Bao H, Chen Z
Antioxidants & redox signaling 2025 May;42(13-15):787-806
Antioxidants & redox signaling 2025 May;42(13-15):787-806
Activation of sigma 1 receptor attenuates doxorubicin-induced cardiotoxicity by alleviating oxidative stress, mitochondria dysfunction, ER stress-related apoptosis, and autophagy impairment.
Al-Maamari A, Sultan M, Wu S, Zhang T, Wang C, Han B, Duan Y, Ding SS, Chen N, Zhang H, Sun F, Chen X, Yu D, Su S
International journal of biological macromolecules 2025 May;310(Pt 4):143549
International journal of biological macromolecules 2025 May;310(Pt 4):143549
Molecular structure of VEGFA polysaccharide protein and its regulation of monocyte infiltration and oxidative stress after myocardial infarction.
Huang Z, Wen B, Wang M, Lu Y, Ji Q, Mei J, Shi X, Jiang Z
International journal of biological macromolecules 2025 May;310(Pt 3):143199
International journal of biological macromolecules 2025 May;310(Pt 3):143199
Regulation of Nrf2/GPX4 Signaling Pathway by Hyperbaric Oxygen Protects Against Depressive Behavior and Cognitive Impairment in a Spinal Cord Injury Rat Model.
Li C, Wu Z, Chen F, Dai C, Yang X, Ye S, Shi M, Chen P, Liu X, Liu F
CNS neuroscience & therapeutics 2025 May;31(5):e70421
CNS neuroscience & therapeutics 2025 May;31(5):e70421
Hyaluronic acid-modified PtPdCo-CQ nanocatalyst with triple enzyme-like activities regulates macrophage polarization and autophagy levels for the treatment of rheumatoid arthritis.
Zhang L, Wu G, Yao J, Wang D, Gao F, Qian Z
International journal of biological macromolecules 2025 May;309(Pt 4):143143
International journal of biological macromolecules 2025 May;309(Pt 4):143143
A Keap1-recruiting BRD4 degrader offers a single-molecular polypharmacology approach for the treatment of metabolic dysfunction-associated steatohepatitis.
Zhang X, Ge Y, Ye M, Wang X, Tong Y, Liu C, Xu S, Zhao Z, You Q, Guo X, Jiang Z
Free radical biology & medicine 2025 May;232:15-27
Free radical biology & medicine 2025 May;232:15-27
EPA-enriched lipid from Apostichopus japonicus byproducts mitigates UVB-induced oxidative stress and inflammation by gut-skin axis.
Qu C, Liang S, Wang K, He Y, Ju W, Sun Y, Miao J
Food research international (Ottawa, Ont.) 2025 May;208:116085
Food research international (Ottawa, Ont.) 2025 May;208:116085
Acupuncture attenuates myocardial ischemia/reperfusion injury-induced ferroptosis via the Nrf2/HO-1 pathway.
Li X, Sun YX, Tjahjono AW, Wei Y, Li X, Zheng QH, Qi WC, Liang FR
Chinese medicine 2025 May 9;20(1):61
Chinese medicine 2025 May 9;20(1):61
Rilmenidine attenuates intracerebral hemorrhage by regulating autophagy flux and apoptosis via the HO-1/Fe(2+)/ERK pathway.
Hua Q, Lu M, Li Z, Song P, Gao L, Zhou L, Zhang J, Cai Q
Neuroscience 2025 May 7;573:382-398
Neuroscience 2025 May 7;573:382-398
Identification of HMOX-1-Targeting Natural Compounds in Camellia nitidissima Chi for NSCLC Therapy: Integrating Bioassay and In Silico Screening Approaches.
Zhang L, Zhang F, Liang H, Qin X, Liang C, Zhong M, Mo Y, Xie J, Hou X, Deng J, Hao E, Du Z
Pharmaceuticals (Basel, Switzerland) 2025 May 30;18(6)
Pharmaceuticals (Basel, Switzerland) 2025 May 30;18(6)
Astragali radix - Curcumae rhizoma herb pair suppresses hepatocellular carcinoma through EGFR/AKT/mTOR pathway and induces lipid peroxidation-related ferroptosis via HIF-1α/HO-1/GPX4 axis.
Wang C, Shi CH, Bai HY, Lu J, Hu HT, Sun YM, Gao H, An H, Lu JH, Zhao HJ, Zhu ZH
Journal of ethnopharmacology 2025 May 28;348:119912
Journal of ethnopharmacology 2025 May 28;348:119912
Ethanol extract of Moschus attenuates glutamate-induced cytotoxicity in HT22 cells by regulating the Nrf2 and MAPK pathways.
Chu Z, Chen Y, Xie D, Song C, Yang L, Qin T, Zhai Z, Cao Z, Xu Y, Sun T
Journal of ethnopharmacology 2025 May 28;348:119879
Journal of ethnopharmacology 2025 May 28;348:119879
Melatonin inhibits salivary gland epithelial cell ferroptosis via the NRF2/HO-1/GPX4 signaling pathway in primary Sjögren's syndrome.
Weng X, Wang S, Wang Q, Wei M, Cheng B
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 May 24;74(1):84
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 May 24;74(1):84
Ferroptotic Pathway Activation in Spermatogonia: A Novel Mechanism of Busulfan-Induced Testicular Injury.
Hu H, Yuan W, Wang Y, Dong Z, Chen G
Biology 2025 May 23;14(6)
Biology 2025 May 23;14(6)
Ursolic acid suppresses ferroptosis by modulating Th17/Treg balance and gut dysbiosis in experimental autoimmune thyroiditis rats.
Mou L, Huang B, Xie W, Li B, Hong Z, Huang X, Liu X, Zhang Y
International immunopharmacology 2025 May 16;155:114569
International immunopharmacology 2025 May 16;155:114569
Exposure to Sucralose and Its Effects on Testicular Damage and Male Infertility: Insights into Oxidative Stress and Autophagy.
Chiang YF, Chen YC, Huang KC, Ali M, Hsia SM
Environmental health perspectives 2025 May 16;
Environmental health perspectives 2025 May 16;
Lithospermic acid alleviates oxidative stress and inflammation in DSS-induced colitis through Nrf2.
Zhao Y, Tian X, Yan Y, Tian S, Liu D, Xu J
European journal of pharmacology 2025 May 15;995:177390
European journal of pharmacology 2025 May 15;995:177390
Unraveling the impact of micro- and nano-sized polymethyl methacrylate on gut microbiota and liver lipid metabolism: Insights from oral exposure studies.
Zheng PC, Pan XQ, Zhou YJ, Lai KP, Li R, Zhang XX
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126157
Environmental pollution (Barking, Essex : 1987) 2025 May 15;373:126157
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata.
Xu W, Li XJ, Zhong YS, He JQ, Xie W, Kang YK, Ying HZ, Yu CH
Carbohydrate polymers 2025 May 15;356:123381
Carbohydrate polymers 2025 May 15;356:123381
Corynoxeine Supplementation Ameliorates Colistin-Induced Kidney Oxidative Stress and Inflammation in Mice.
Liu Y, Zhang R, Velkov T, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2025 May 15;14(5)
Antioxidants (Basel, Switzerland) 2025 May 15;14(5)
ROS-responsive dextran-benzeneboronic acid pinacol ester micelles encapsulating edaravone for the treatment and mechanism of cerebral ischemia-reperfusion injury.
Zhao H, Yang P, Zhang M, Zheng W, Qi R, Zhu X, Li J, Li S
Metabolic brain disease 2025 May 13;40(5):202
Metabolic brain disease 2025 May 13;40(5):202
Engineered Spirulina platensis for treating rheumatoid arthritis and restoring bone homeostasis.
Yang X, Rong K, Fu S, Yang Y, Liu S, Zhang C, Xu K, Zhang K, Zhu Y, Hao Y, Zhao J, Fu J
Nature communications 2025 May 13;16(1):4434
Nature communications 2025 May 13;16(1):4434
Isorhamnetin Attenuates Isoproterenol-Induced Myocardial Injury by Reducing ENO1 (Alpha-Enolase) in Cardiomyocytes.
Guo Z, Liu S, Hou X, Zhou X, Wang Y, Rong Y, Li X, Yang R, Ma K
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Tea Polyphenols Mitigate Radiation-Induced Ferroptosis and Intestinal Injury by Targeting the Nrf2/HO-1/GPX4 Signaling Pathway.
Li R, Li L, Wu H, Gan H, Wu Z, Gu R, Zhu X, Liu S, Meng Z, Dou G
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Antioxidants (Basel, Switzerland) 2025 May 11;14(5)
Curcumin Alleviates Microglia-Mediated Neuroinflammation and Neuronal Ferroptosis Following Experimental Subarachnoid Hemorrhage by Modulating the Nrf2/HO-1 Signaling Pathway.
Xu Y, Liu Y, Wu Y, Sun J, Lu X, Dai K, Zhang Y, Luo C, Zhang J
Molecular neurobiology 2025 Mar;62(3):2995-3010
Molecular neurobiology 2025 Mar;62(3):2995-3010
Metformin reverses infertility in a mouse model of endometriosis: unveiling disease pathways and implications for future clinical approaches.
Neto AC, Botelho M, Rodrigues AR, Lamas S, Araújo B, Guimarães JT, Gouveia AM, Almeida H, Neves D
Reproductive biomedicine online 2025 Mar;50(3):104474
Reproductive biomedicine online 2025 Mar;50(3):104474
The potential role of the SIRT1-Nrf2 signaling pathway in alleviating hidden hearing loss via antioxidant stress.
Zheng Z, Zhang P, Fu Y, Jiang Y, Zhu J, Wang F, Li S, Zhang Z, Chang T, Li T, Zhang M, Ruan B, Wang X
Cell biology international 2025 Mar;49(3):262-276
Cell biology international 2025 Mar;49(3):262-276
Single amino acid substitution analogs of marine antioxidant peptides with membrane permeability exert a marked protective effect against ultraviolet-B induced damage.
Huang Y, He Q, Zhang P, Song J, Wang Y, Zhu S, Lv Y, Zhou D, Hu Y, Zhang L, Liu G, Wang Q
Journal of photochemistry and photobiology. B, Biology 2025 Mar;264:113120
Journal of photochemistry and photobiology. B, Biology 2025 Mar;264:113120
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease.
Wang H, Zhao X, Wang X, Gong Y, Li S, Gu Y, He B, Wang J
Biochemical pharmacology 2025 Mar;233:116795
Biochemical pharmacology 2025 Mar;233:116795
Boric Acid Alleviates Lipopolysaccharide-Induced Acute Lung Injury in Mice.
Zhang X, Wang G, Chen S
Biological trace element research 2025 Mar;203(3):1494-1501
Biological trace element research 2025 Mar;203(3):1494-1501
SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells.
Wang L, Song J, Yang Z, Zhang H, Wang Y, Liu J, Wang S, Shi J, Tong X
Journal of molecular and cellular cardiology 2025 Mar;200:68-81
Journal of molecular and cellular cardiology 2025 Mar;200:68-81
The protective effect and potential mechanism of Zanthoxylum bungeanum Maxim. on atherosclerosis.
Li Z, Xu R, Li C, Chi C, Yang X, Yang S, Liu R
Fitoterapia 2025 Mar;181:106394
Fitoterapia 2025 Mar;181:106394
Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4.
Guo Y, Wang J, Zhang D, Tang Y, Cheng Q, Li J, Gao T, Zhang X, Lu G, Liu M, Guan X, Tang X, Gu J
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1480-1496
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1480-1496
Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.
Liao X, Tang M, Li J, Guo R, Zhong C, Chen X, Zhang X, Mo H, Que D, Yu W, Song X, Li H, Cai Y, Yang P
Advanced healthcare materials 2025 Mar;14(7):e2404319
Advanced healthcare materials 2025 Mar;14(7):e2404319
Oxymatrine alleviates ALD-induced cardiac hypertrophy by regulating autophagy via activation Nrf2/SIRT3 signaling pathway.
Lu D, Wu S, Wang X, Zhang J, Xu Y, Tao L, Shen X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156389
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156389
Rosa roxburghii Fermentation Broths Attenuate Bleomycin-Induced Pulmonary Fibrosis by Activating the Nrf2/HO-1/NQO1 Signaling Pathway and Modulating Gut Microbiota.
Zhou H, Zheng X, Huang S, Wang X, Zhou T, Zhang S, Ling Y, Wang W, Li X, Li S, Xie Y, Yin W
Food science & nutrition 2025 Mar;13(3):e70105
Food science & nutrition 2025 Mar;13(3):e70105
Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination.
Xu W, Hua Z, Wang Y, Tang W, Ge W, Chen Y, Wang Z, Gu Y, Liu CY, Du P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2411320
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2411320
Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise.
Cheng C, Zhang S, Chen C, Gong Y, Ding K, Li G, Jiang W, Zhang Z, He B, Hu Z, Li Y, Yao L
Scientific reports 2025 Mar 9;15(1):8141
Scientific reports 2025 Mar 9;15(1):8141
Dihydromyricetin Alleviated Acetaminophen-Induced Acute Kidney Injury via Nrf2-Dependent Anti-Oxidative and Anti-Inflammatory Effects.
Shi J, Peng X, Huang J, Zhang M, Wang Y
International journal of molecular sciences 2025 Mar 6;26(5)
International journal of molecular sciences 2025 Mar 6;26(5)
Adropin-Driven Browning: Targeting M2 Macrophages to Combat PCOS.
Zhang S, Li J, Lv X, Pan G, Liu Q, Zheng L, Xu L
International immunopharmacology 2025 Mar 6;149:114273
International immunopharmacology 2025 Mar 6;149:114273
Klotho alleviates oxidative stress and mitochondrial dysfunction through the Nrf2/HO-1 pathway, thereby reducing renal senescence induced by calcium oxalate crystals.
Xu Y, You J, Yao J, Hou B, Wang W, Hao Z
Urolithiasis 2025 Mar 29;53(1):61
Urolithiasis 2025 Mar 29;53(1):61
Electroacupuncture Attenuates Intestinal Barrier Disruption via the α7nAChR-Mediated HO-1/p38 MAPK/NF-κB Pathway in a Mouse Model of Metabolic Dysfunction-Associated Fatty Liver Disease: A Randomized, Single-Blind, Controlled Trial.
Wang X, Sun J, Wang P, Zhang Y, Chang J, Duan Z
Biomedicines 2025 Mar 27;13(4)
Biomedicines 2025 Mar 27;13(4)
Wedelolactone activates the PI3K/AKT/NRF2 and SLC7A11/GPX4 signalling pathways to alleviate oxidative stress and ferroptosis and improve sepsis-induced liver injury.
Yin Y, Mu F, Zhang L, Zhao J, Gong R, Yin Y, Zheng L, Du Y, Jin F, Wang J
Journal of ethnopharmacology 2025 Mar 26;344:119557
Journal of ethnopharmacology 2025 Mar 26;344:119557
Ditan Decoction ameliorates vascular dementia-induced cognitive dysfunction through anti-ferroptosis via the HIF1α pathway: Integrating network pharmacology and experimental validation.
Gu M, Sun L, Yang J, Wang K, Wu F, Zheng L, Shen X, Lai X, Gong L, Peng Y, Xu S, Yang J, Yang C
Journal of ethnopharmacology 2025 Mar 26;344:119459
Journal of ethnopharmacology 2025 Mar 26;344:119459
Reprogramming Macrophage Phenotype Using a Reactive Oxygen Species-Responsive Liposome Delivery System for Inflammation Microenvironment Remodeling and Osteoarthritis Treatment.
Lai P, Ma Y, Sang W, Zhou Q, Chen H, Wang C, Yin J, Wang T, Zhu L, Zhou X, He C, Ma J
ACS applied materials & interfaces 2025 Mar 26;17(12):17932-17947
ACS applied materials & interfaces 2025 Mar 26;17(12):17932-17947
ROS-responsive nanoparticles with selenomethionine for ferroptosis modulation in abdominal aortic aneurysm.
He H, Chen L, Peng J, Guo J, Xiao X, Dou C, Chen H, Zhan S, Han X, Yao W
iScience 2025 Mar 21;28(3):111880
iScience 2025 Mar 21;28(3):111880
Phenethyl isothiocyanate ameliorates liver injuries secondary to inflammatory bowel disease.
Ma C, Zhang L, Huang Q, Deng Q, Huang F, Xu J
Food & function 2025 Mar 17;16(6):2589-2597
Food & function 2025 Mar 17;16(6):2589-2597
Huachansu Injection induces ferroptosis in multiple myeloma through NRF2/HO-1 signaling pathway.
Yang J, Wang F, Hu Z, Liu X, Zhang W, Li C, Wang W, Reaila J, Zhang X, Zhu G, Tian F, Chen B, Zhu X
Journal of ethnopharmacology 2025 Mar 13;343:119454
Journal of ethnopharmacology 2025 Mar 13;343:119454
Carbon monoxide produced by HO-1 upregulation is the main factor behind the abnormal motility seen in experimental ulcerative colitis in mice.
Zhao M, Lei Y, Wang M, Chen Y, Hou S, Dai X, Gao D, Liu Y, Mazet B, Sha L
American journal of physiology. Gastrointestinal and liver physiology 2025 Mar 1;328(3):G311-G322
American journal of physiology. Gastrointestinal and liver physiology 2025 Mar 1;328(3):G311-G322
Astaxanthin ameliorates benzalkonium chloride-induced dry eye disease through suppressing inflammation and oxidative stress via Keap1-Nrf2/HO-1 signaling pathways.
Liu Z, Li Y, Bao J, Li S, Wen Y, Zhang P, Feng J, Wang Y, Tian L, Jie Y
Animal models and experimental medicine 2025 Jun;8(6):1056-1079
Animal models and experimental medicine 2025 Jun;8(6):1056-1079
Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity.
Li J, Tang Y, Lu G, Liu Q, Guo Y, Wang J, Xiao M, Gao T, Zhang X, Gu J
Journal of advanced research 2025 Jun;72:165-180
Journal of advanced research 2025 Jun;72:165-180
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
Lin J, Sun Y, Huang H, Yu C, Kuang W, Wang Y, Zhu L
Molecular neurobiology 2025 Jun;62(6):7054-7074
Molecular neurobiology 2025 Jun;62(6):7054-7074
Honokiol attenuates oxidative stress and vascular calcification via the upregulation of heme oxygenase-1 in chronic kidney disease.
Xian X, Zhao X, Zhou X, Liu H, Li C, Wu X, Chen Y, Ye K, Yang H, Li M, Yan J, Zhang X
Toxicology and applied pharmacology 2025 Jun;499:117318
Toxicology and applied pharmacology 2025 Jun;499:117318
Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction.
Zhao HM, Mu LQ, Wang J, Chen RZ, Li Y, Zhao L, Zhao Y, Liu LN
Current medical science 2025 Jun;45(3):469-480
Current medical science 2025 Jun;45(3):469-480
Fisetin alleviates oxidative stress and promotes porcine early embryonic development via activation of the NRF2-ARE signalling pathway.
Wei HK, Qi JJ, Wang YQ, Qu HX, Yan CX, Li TT, Wang Y, Sun H, Sun BX, Liang S
Animal bioscience 2025 Jun;38(6):1160-1174
Animal bioscience 2025 Jun;38(6):1160-1174
Hydrogel-mediated mitochondrial reprogramming for inducing cell death: a novel approach to overcoming gemcitabine resistance in pancreatic ductal adenocarcinoma.
Zhao Q, Liu S, Bi T, Wang T, Chen L, Huang J, Yang X, Dai X, Liu Z, Sun Q
Materials today. Bio 2025 Jun;32:101940
Materials today. Bio 2025 Jun;32:101940
Novel pH-responsive lipid nanoparticles deliver UA-mediated mitophagy and ferroptosis for osteoarthritis treatment.
Yi G, Li M, Zhou J, Li J, Song X, Li S, Liu J, Zhang H, Chen Z
Materials today. Bio 2025 Jun;32:101697
Materials today. Bio 2025 Jun;32:101697
Polygonati kingianum polysaccharide alleviates dextran sulfate sodium-induced colitis by modulating gut microbiota and metabolic homeostasis.
Fan H, Zhao H, Zheng Y, Chen G, Ji Y, Yu W, Yan J, Yang H, Liang X, Chen Y
International journal of biological macromolecules 2025 Jun;316(Pt 2):144836
International journal of biological macromolecules 2025 Jun;316(Pt 2):144836
CuATSM Enhances Wound Repair Without Scarring via Hippo/YAP Signalling Pathway to Reduce Ferroptosis and Macrophage Polarisation.
Tang Y, Ye J, Xu T, Sun Y, Meng W, Zhu L, Jia Z, Wu Q, Chen D, Wu F
Journal of cellular and molecular medicine 2025 Jun;29(12):e70590
Journal of cellular and molecular medicine 2025 Jun;29(12):e70590
Astragaloside IV Relieves Mitochondrial Oxidative Stress Damage and Dysfunction in Diabetic Mice Endothelial Progenitor Cells by Regulating the GSK-3β/Nrf2 Axis.
Zou X, Liu X, Qu W, Zhang X, Zou Y, Lin X, Hu W, Gao R, He Y, Zhou S, Huang Y, Xiong W
Applied biochemistry and biotechnology 2025 Jun;197(6):3964-3981
Applied biochemistry and biotechnology 2025 Jun;197(6):3964-3981
Aminolevulinate/iron exposure elicited Nrf-2-mediated cytoprotection in DARS2 deficient fibroblasts with impaired energy and antioxidant metabolisms.
Huang WL, Eichwald T, Stover A, Gazanfari M, Schwartz PH, Latini A, Abdenur JE
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167824
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167824
Liposome of Phlorizin promote the repair of carotid atherosclerosis in rats by regulating inflammation and the Nrf2 signaling pathway.
Wu X, Ding C, Liu X, Ding Q, Zhang S, Wang Y, Zhao T, Liu W
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159613
Biochimica et biophysica acta. Molecular and cell biology of lipids 2025 Jun;1870(5):159613
Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
Gan X, Li J, Jiang Y, Wang X, Zeng Y, Chen X, Huang H, Min J, Li G, Nie M, Kang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156697
Influence of α-Linolenic Acid on the Intestinal Barrier Integrity and Intestinal Antioxidant Status in Broilers.
Kang A, Ni J, Cheng X, Wu S, Liu Y, Ma W, Wang D
Food science & nutrition 2025 Jun;13(6):e70271
Food science & nutrition 2025 Jun;13(6):e70271
Pterostilbene Reduces Cyclophosphamide-Induced Interstitial Cystitis by Facilitating Nrf2 Activation and Suppressing the NLRP3 Inflammasome Pathway.
Zhang J, Wang J, Wang X, Yan Z, Meng L, Zhang Y
International journal of molecular sciences 2025 Jun 8;26(12)
International journal of molecular sciences 2025 Jun 8;26(12)
Cerium-Organic Framework and Resveratrol Composite Hydrogel Scaffold with Dual Antioxidant Activity for Enhanced Bone Regeneration.
Lu Y, Zhang L, Yang B, Hu H, Sun H, Guo D
ACS applied materials & interfaces 2025 Jun 4;17(22):31828-31842
ACS applied materials & interfaces 2025 Jun 4;17(22):31828-31842
TRIM19 enhances the chemosensitivity of endometrial cancer by regulating the TBX2/NRF2 axis.
Ding N, Li Y, Yu X
Discover oncology 2025 Jun 4;16(1):997
Discover oncology 2025 Jun 4;16(1):997
Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy.
Xiang D, Zhang X, Xue X, Liang H, Meng J, Zhao S, Yang J, Zhou Y, Hu Y, Xu L, Shi M, Zhang J, Wang M, Chen J, Han Y
Journal of ethnopharmacology 2025 Jun 26;350:120055
Journal of ethnopharmacology 2025 Jun 26;350:120055
Quercetin, as a Nutritional Supplement, Protects against Iron Overload-Induced Testicular Dysfunction via Inhibiting Ferroptosis.
Yuan W, Ji G, Wang X, Li W, Sun Z, Wei Z, Shi X, Hu H
Journal of agricultural and food chemistry 2025 Jun 25;73(25):15579-15595
Journal of agricultural and food chemistry 2025 Jun 25;73(25):15579-15595
Fibroblast growth factor 18 attenuates renal fibrosis via AMPK/NOX4 pathway in mice.
Zhou J, Shou Y, Shi Q, Ye J, Li X, Zhu Z, Wang X
Biochemical and biophysical research communications 2025 Jun 20;766:151913
Biochemical and biophysical research communications 2025 Jun 20;766:151913
Computational design of diverse nuclear factor erythroid 2 activators with cellular antioxidative activity.
Yuwen M, Gao X, Ba J, Wu J, Kang J, Ye S, Zhu C
iScience 2025 Jun 20;28(6):112621
iScience 2025 Jun 20;28(6):112621
RTA 408 attenuates TBHP-Induced apoptosis in nucleus pulposus cells via Nrf2/ARE and NF-κB signaling pathways: in vitro and in vivo evidence for mitigating rats' intervertebral disc degeneration.
Chen W, Li D, Chen L, Fei J, Bian M, Zeng Q, Jiang Z, Wu J
Arthritis research & therapy 2025 Jun 19;27(1):128
Arthritis research & therapy 2025 Jun 19;27(1):128
Mechanisms of Aletris spicata (Thunb.) Franch. Extract in Asthma Therapy: Oxidative Stress, Inflammation, and Gut Microbiota.
Yang J, Chen Z, Zhu Y, Chen T, Zhou Y, Wang Z
Biology 2025 Jun 19;14(6)
Biology 2025 Jun 19;14(6)
Ferulic acid identification in brown rice using untargeted metabolomics and network analysis and its effects in mitigating AFB1-induced hepatic damage.
Wang Q, Wang G, Wang Y, Fang X, Fu Y, Li G, Huang S, Ma Q, Zhao L
Food & function 2025 Jun 16;16(12):4970-4982
Food & function 2025 Jun 16;16(12):4970-4982
Daidzein alleviates CCl(4)- and BDL-induced liver fibrosis via suppressing the integrin alphaVbeta1/YAP signaling.
Bai J, Yang Z, Wang P, Qian B, Jiang Z, Xu T, Pu H, Ye M, Du Y, Fu W
Food & function 2025 Jun 16;16(12):4822-4836
Food & function 2025 Jun 16;16(12):4822-4836
Overexpression of the circadian gene Bmal1 regulates the Nrf2/HO-1 oxidative stress pathway to alleviate inflammation and apoptosis in PC12 cells following cerebral ischemia-reperfusion injury.
Zeng F, Wang M, Li Z, Zhang Y
Medicine 2025 Jun 13;104(24):e42763
Medicine 2025 Jun 13;104(24):e42763
Meloxicam Alleviates Oxidative Stress Through Nrf2/HO-1 Activation in Bovine Endometrial Epithelial Cells.
Cui L, Duan J, Mao P, Zhong J, He S, Dong J, Liu K, Guo L, Li J, Wang H
Veterinary sciences 2025 Jun 12;12(6)
Veterinary sciences 2025 Jun 12;12(6)
Ambient fine particulate matter induces cardiac fibrosis through triggering ferroptosis by heme degradation induced-iron overload.
Jiang J, Li Y, Chen Y, Wu Q, Ding S
Ecotoxicology and environmental safety 2025 Jun 1;297:118227
Ecotoxicology and environmental safety 2025 Jun 1;297:118227
Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.
Li Q, Huang Y, Ban T, Chen K, Zhen X, Dai Q, Zhang G
Neuropharmacology 2025 Jun 1;270:110374
Neuropharmacology 2025 Jun 1;270:110374
Δ(9)-tetrahydrocannabinol induces blood-brain barrier disruption: Involving the activation of CB1R and oxidative stress.
Zhang Q, Huang W, Li T, Wang X, Lai X, Hu W, Li Z, Zeng X, Huang J, Zhang R
Neuropharmacology 2025 Jun 1;270:110366
Neuropharmacology 2025 Jun 1;270:110366
Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2.
Jiang Z, Liu D, Li T, Gai C, Xin D, Zhao Y, Song Y, Cheng Y, Li T, Wang Z
Neural regeneration research 2025 Jun 1;20(6):1776-1788
Neural regeneration research 2025 Jun 1;20(6):1776-1788
MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.
Li X, Zhan F, Qiu G, Lu P, Shen Z, Qi Y, Wu M, Chu M, Feng J, Wen Z, Yao X, Wang A, Jin W, Zhang X, Liao J, Zhang J, Song M, Wang W, Wang X
Redox biology 2025 Jul;84:103681
Redox biology 2025 Jul;84:103681
Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4-regulated ferroptosis.
Wen SY, Gao RR, Chen YY, Wang YJ, Wang XT, Liu HX
Animal models and experimental medicine 2025 Jul;8(7):1155-1165
Animal models and experimental medicine 2025 Jul;8(7):1155-1165
Direct Peritoneal Resuscitation and Melatonin in the Treatment of Abdominal Sepsis-Induced Lung Injury via Macrophage Metabolic Reprogramming.
Zhao Z, Ji J, Ming L, Luo Z, Li M, Chen Y, Sun R, Lu W, Tian W, Yang F, Huang Q
Journal of pineal research 2025 Jul;77(4):e70066
Journal of pineal research 2025 Jul;77(4):e70066
Alleviating Effect and Potential Mechanisms of Selenium Supplementation on Chronic Liver Injury Induced by Oxidized Soybean Oil.
Tian H, Li P, Lin L, Fan S, Li R, Zhou L, Zhao Q, Zhang J, Tang C
Molecular nutrition & food research 2025 Jul;69(14):e70124
Molecular nutrition & food research 2025 Jul;69(14):e70124
Empagliflozin Inhibits Neuronal Ferroptosis Induced by Oxygen-Glucose Deprivation/Reoxygenation by Activating the Nrf2/HO-1 Pathway.
Ma J, Wang H, Jia J, Tao T, Shan L, Sun S, Wang M
Molecular neurobiology 2025 Jul;62(7):8768-8781
Molecular neurobiology 2025 Jul;62(7):8768-8781
Carfilzomib promotes Iodine-125 seed radiation-induced apoptosis, paraptosis, and ferroptosis in esophageal squamous cell carcinoma by aggravating endoplasmic reticulum stress.
Wang C, Zha YL, Wang H, Sun B, Qiang WG, Yuan Y, Shi HB, Hu WW
Translational oncology 2025 Jul;57:102393
Translational oncology 2025 Jul;57:102393
Ferroptosis Mediates the Progression of Hyperuricemic Nephropathy by Activating RAGE Signaling.
Wang Q, Xi Y, Zhao H, Xie D, Yu L, Yan Y, Chen J, Zhang Q, Liang M, Cheng J
Antioxidants & redox signaling 2025 Jul;43(1-3):56-74
Antioxidants & redox signaling 2025 Jul;43(1-3):56-74
Methacrylated sericin/methacrylated hyaluronic acid composite microneedles with exosomes for diabetic wound healing.
Xu X, Shen Y, Wu J, Hong F, Xia H, Chen X, Lin G, Liu L, Xu RA
International journal of biological macromolecules 2025 Jul;318(Pt 1):144957
International journal of biological macromolecules 2025 Jul;318(Pt 1):144957
Coriander-Derived Exosome-Like Nanovesicles Laden Hydrogel with Antioxidant Property Accelerates Wound Healing.
Wang T, Li Y, Hao L, Liu Y, Liu D, Zhang C, Yi H, Zhang J
Macromolecular bioscience 2025 Jul;25(7):e2400640
Macromolecular bioscience 2025 Jul;25(7):e2400640
Lead (Pb) Induces Osteotoxicity Through the Activation of Mutually Reinforced ER Stress and ROS in MC3T3-E1 Cells.
Xie S, Yin M, Xiang M, Shao L, Zhang N, Shi L, Zhang J, Yu G
Biological trace element research 2025 Jul;203(7):3820-3832
Biological trace element research 2025 Jul;203(7):3820-3832
Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction.
Lu Z, Chai Q, Dai W, Yu B, Lv Q, Qiu F, Gao J, Zhang J, Shen X, Chen S, Shen Z, Shang M, Zhang W, Fu G, Jin Q, Zhao Y, Jia F
Journal of nanobiotechnology 2025 Jul 8;23(1):496
Journal of nanobiotechnology 2025 Jul 8;23(1):496
Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer.
Yu D, Hu H, Zhang Q, Wang C, Xu M, Xu H, Geng X, Cai M, Zhang H, Guo M, Lu D, Xu H, Li L, Zhang X, Shen R, Lin S, Wang Q, Zhang W, Liu S
Signal transduction and targeted therapy 2025 Jul 7;10(1):211
Signal transduction and targeted therapy 2025 Jul 7;10(1):211
Dihydromyricetin attenuates intervertebral disc degeneration by inhibiting NLRP3 inflammasome activation via the Keap1/Nrf2/HO-1 pathway.
Hong H, Guo D, Xia T, Zhang Y
European journal of pharmacology 2025 Jul 5;998:177501
European journal of pharmacology 2025 Jul 5;998:177501
Macrophage-mimetic liposomes co-delivering ceria and Ac2-26 peptide for penumbra protection in ischemic stroke.
Bai L, Li N, Li H, Dai Y, Bai Y, Ma F, Sha D, Xia S, Xu Y, Cao X
Journal of nanobiotechnology 2025 Jul 5;23(1):488
Journal of nanobiotechnology 2025 Jul 5;23(1):488
Nanosilicates promote angiogenesis through activation of ROS-mediated WNT/β-catenin pathway.
Lokhande G, Singh KA, Roy S, Soukar J, Kersey A, Borkar P, Biswas S, Syed RUR, Keller A, Bayless KJ, Singh I, Gaharwar AK
Science advances 2025 Jul 4;11(27):eado1223
Science advances 2025 Jul 4;11(27):eado1223
Parishin C Attenuates Oxidative Stress and Inflammation in HT22 Hippocampal Neurons and BV2 Microglia Through Nrf2 Signaling Pathway.
Wang Y, Wu W, Wu X, Shah BA, Lombardo M, Ye G
International journal of molecular sciences 2025 Jul 27;26(15)
International journal of molecular sciences 2025 Jul 27;26(15)
DNA damage response pathway regulates Nrf2 in response to oxidative stress.
Jiang XY, Guo QQ, Wang SS, Guo R, Zou Y, Liu JW, Feng YL, Guo Y, Li YH, Liu XY, Zhang XY, Hao S, Wu XX, Li MH, Liu A, Li CL, Guo WD, Xu HD, Song XY, Finkel T, Cao L
Science advances 2025 Jul 25;11(30):eadu9555
Science advances 2025 Jul 25;11(30):eadu9555
Antler base (Cervus nippon Temminck) peptides modulate the NLRP3 inflammatory pyroptosis and Nrf2/HO-1/NQO1 signaling pathways to ameliorate osteoarthritis: a structural and mechanistic study.
Sun S, Qiu H, Wang C, Zhang K, Zhao H, Zhao H, Shen Y, Wang Y, Zhang Y
Journal of ethnopharmacology 2025 Jul 24;351:120149
Journal of ethnopharmacology 2025 Jul 24;351:120149
Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.
Liu L, Ma Y, Jian Z, Liao B, Li Y, Lin L, Wang M, Chen J, Wei J, Yang M, Liu Y, Yuan Y, Wen J, Xiang L, Qi S, Jin X, Wang K
Cell reports 2025 Jul 22;44(7):115936
Cell reports 2025 Jul 22;44(7):115936
Dopamine Alleviated Diabetic Retinal Neurodegeneration through Protecting Retinal Ganglion Cells from Ferroptosis via the Nrf2/HO‑1 Signaling Pathway.
Rao S, Xiao K, Chen X, Sun X
ACS omega 2025 Jul 22;10(28):30397-30410
ACS omega 2025 Jul 22;10(28):30397-30410
Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.
Zhang S, Tang F, Zhou Z, Li L, Tang Y, Fu K, Tan Y, Li L
International journal of molecular sciences 2025 Jul 11;26(14)
International journal of molecular sciences 2025 Jul 11;26(14)
AGGF1-primed endothelial progenitor cells alleviate ischaemia-reperfusion injury in diabetic hearts.
Li X, Mu S, Huang S, Dai C, Li Y, Li J, Zhong L, Wei M, Wei L, Li Y
Scientific reports 2025 Jul 1;15(1):21803
Scientific reports 2025 Jul 1;15(1):21803
Naringin mitigates experimental autoimmune prostatitis by modulating oxidative stress and the NLRP3 inflammasome via the PPAR-γ/NF-κB pathway.
Zhou W, Zhang XR, Qin XC, Xie YC, Zhang D, Wang ZC, Zhang CX
Scientific reports 2025 Jul 1;15(1):20843
Scientific reports 2025 Jul 1;15(1):20843
Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/ HO-1 Pathway.
Xiao T, Zhao H, Wang Y, Chen M, Wang C, Qiao C
Diabetes & metabolism journal 2025 Jan;49(1):34-48
Diabetes & metabolism journal 2025 Jan;49(1):34-48
Salmonella enterica serovar typhimurium effectors spiA and spiC promote replication by modulating iron metabolism and oxidative stress.
Chen K, Wang J, Hu T, Zhao Y, Wu Y, Wang X, Li W, Yang G, Zhang L, Wang J, Zhu Y
Veterinary microbiology 2025 Jan;300:110328
Veterinary microbiology 2025 Jan;300:110328
Structural characterization and in vitro hepatoprotective activity of an acidic polysaccharide from Dendrobium nobile Lindl. flower.
Li Y, Duan X, Wang Y, Deng Y, Zhang J
International journal of biological macromolecules 2025 Jan;284(Pt 1):138100
International journal of biological macromolecules 2025 Jan;284(Pt 1):138100
Supramolecular nanoparticle loaded with bilirubin enhances cartilage protection and alleviates osteoarthritis via modulating oxidative stress and inflammatory responses.
Zhao X, Huang H, Jiang X, Zheng S, Qiu C, Cheng Y, Lin Y, Wang Y, Yan Y, Di X, Hu M, Zhu W, Wu F, Shi X, Chen R, Kou L
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114243
Colloids and surfaces. B, Biointerfaces 2025 Jan;245:114243
Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways.
Zhang J, Yuan Y, Gao X, Li H, Yuan F, Wu D, Cui Q, Piao G, Yuan H
Biochemical pharmacology 2025 Jan;231:116639
Biochemical pharmacology 2025 Jan;231:116639
Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis.
He S, Ye H, Wang Q, He Y, Liu X, Song J, Zhao C, Hu Y, Luo L, Guo Y, Liu Q
Free radical biology & medicine 2025 Jan;226:13-28
Free radical biology & medicine 2025 Jan;226:13-28
Antiferroptotic properties of allicin and related organosulfur compounds-diallyl disulfide and diallyl trisulfide-from Garlic.
Hirata Y, Nagase H, Satoh K, Takemori H, Furuta K, Kamatari YO
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jan;195:115124
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Jan;195:115124
Ingenane diterpenoids with anti-inflammatory activity from Euphorbia antiquorum.
Ma RF, Wu Q, Pan YP, Liu H, Zhuang XC, Zhang H
Fitoterapia 2025 Jan;180:106350
Fitoterapia 2025 Jan;180:106350
Disruption of Ferroptosis Inhibition and Immune Evasion with Tumor-Activatable Prodrug for Boosted Photodynamic/Chemotherapy Eradication of Drug-Resistant Tumors.
Bi T, Zhao Q, Wang T, Huang R, Liu B, Liu X, Wang Y, Sun Q, Yang Y, Liu Z
Advanced healthcare materials 2025 Jan;14(2):e2403473
Advanced healthcare materials 2025 Jan;14(2):e2403473
Psoralen and Isopsoralen Activate Nuclear Factor Erythroid 2-Related Factor 2 Through Interaction With Kelch-Like ECH-Associated Protein 1.
Lv C, Wang S, Sun C, Liu J, Chen Y, Wang C, Yuan C, Qin F, Li T
Food science & nutrition 2025 Jan;13(1):e4768
Food science & nutrition 2025 Jan;13(1):e4768
The synergistic protective effects of paeoniflorin and β-ecdysterone against cardiac hypertrophy through suppressing oxidative stress and ferroptosis.
Yan P, Li X, He Y, Zhang Y, Wang Y, Liu J, Ren S, Wu D, Zhao Y, Ding L, Jia W, Lyu Y, Xiao D, Lin S, Lin Y
Cellular signalling 2025 Jan;125:111509
Cellular signalling 2025 Jan;125:111509
Effect of different dietary oil sources on the performance, egg quality and antioxidant capacity during the late laying period.
Xu M, Liu L, Fan Z, Niu L, Ning W, Cheng H, Li M, Huo W, Zhou P, Deng H, Chen W, Che L
Poultry science 2025 Jan;104(1):104615
Poultry science 2025 Jan;104(1):104615
Protective Effects of α-Linolenic Acid on Liver Inflammation and Oxidative Stress Induced by Lipopolysaccharide in Broilers.
Cheng X, Zhang X, Ni J, Ding H, Ma W, Wang D
Animal science journal = Nihon chikusan Gakkaiho 2025 Jan-Dec;96(1):e70096
Animal science journal = Nihon chikusan Gakkaiho 2025 Jan-Dec;96(1):e70096
Pedunculoside inhibits cardiomyocyte inflammatory biomarkers via Nrf2/HO-1 pathway in high glucose-induced H9c2 cells and diabetic cardiomyopathy model rats.
Lu Y, Meng J, Zhu D, Jiang Z, Ma H
Human & experimental toxicology 2025 Jan-Dec;44:9603271251322186
Human & experimental toxicology 2025 Jan-Dec;44:9603271251322186
Gegen Qinlian Decoction inhibits liver ferroptosis in type 2 diabetes mellitus models by targeting Nrf2.
Zhang X, Ji Z, He Q, Yang D, Wang X, Liu C, Zhang C, Yuan J, Xu N, Chu J
Journal of ethnopharmacology 2025 Jan 31;340:119290
Journal of ethnopharmacology 2025 Jan 31;340:119290
Tanshinone IIA, a component of Salvia miltiorrhiza Bunge, attenuated sepsis-induced liver injury via the SIRT1/Sestrin2/HO-1 signaling pathway.
Tian W, Song P, Zang J, Zhao J, Liu Y, Wang C, Fang H, Wang H, Zhao Y, Liu X, Gao Y, Cao L
Journal of ethnopharmacology 2025 Jan 31;340:119169
Journal of ethnopharmacology 2025 Jan 31;340:119169
Multi-platform analysis revealed the substance basis and mechanism of Wei-Tong-Xin in ameliorating ENS dysfunction for dyspepsia treatment.
Zhang X, Wang S, Xie J, Wang J, Gu Y, Wu B, Zhang Y, Yan T, Jia Y
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118875
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118875
Extract of Nanhaia speciosa J. Compton & Schrire alleviates LPS-induced acute lung injury via the NF-κB/Nrf2/AQPs pathway.
Zhou S, Hu Y, Liu L, Li L, Deng F, Mo L, Huang H, Liang Q
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118831
Journal of ethnopharmacology 2025 Jan 30;337(Pt 1):118831
Supplementation with carnosine, a food-derived bioactive dipeptide, alleviates dexamethasone-induced oxidative stress and bone impairment via the NRF2 signaling pathway.
Li XY, Gu XY, Li XM, Yan JG, Mao XL, Yu Q, Du YL, Kurihara H, Yan CY, Li WX
Journal of the science of food and agriculture 2025 Jan 30;105(2):1091-1104
Journal of the science of food and agriculture 2025 Jan 30;105(2):1091-1104
HMOX1 as a potential drug target for upper and lower airway diseases: insights from multi-omics analysis.
Wang E, Li S, Li Y, Zhou T
Respiratory research 2025 Jan 27;26(1):41
Respiratory research 2025 Jan 27;26(1):41
Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells.
Zhang Z, Xu H, He J, Hu Q, Liu Y, Xu Z, Lou W, Wu W, Zhang L, Pu N, Shi C, Xu Y, Wang W, Liu L
Cell death & disease 2025 Jan 18;16(1):28
Cell death & disease 2025 Jan 18;16(1):28
Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.
Jia Y, Li R, Li Y, Kachler K, Meng X, Gießl A, Qin Y, Zhang F, Liu N, Andreev D, Schett G, Bozec A
Bone research 2025 Jan 16;13(1):9
Bone research 2025 Jan 16;13(1):9
Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms.
Zhang P, Zhou Z, Yao J, Jiang Y, Lei H, Xie Z, Li J, Zhao X, Zhu L, Wan M, Liu L, Tang W
Ecotoxicology and environmental safety 2025 Jan 15;290:117747
Ecotoxicology and environmental safety 2025 Jan 15;290:117747
Chitosan oligosaccharide alleviates DON-induced liver injury via suppressing ferroptosis in mice.
Liu M, Li Z, Li J, Yan G, Liu C, Yin Q, Liu Y, Xu X
Ecotoxicology and environmental safety 2025 Jan 15;290:117530
Ecotoxicology and environmental safety 2025 Jan 15;290:117530
Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies.
Yin L, He Z, Fan Y, Niu Z, Yao L, Ding S, Chen J, Zhang Q, Tong Y, Bi Q, Cao L
International immunopharmacology 2025 Jan 10;144:113695
International immunopharmacology 2025 Jan 10;144:113695
The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.
Jiang Y, He P, Sheng K, Peng Y, Wu H, Qian S, Ji W, Guo X, Shan X
eLife 2025 Jan 10;13
eLife 2025 Jan 10;13
Cardiac-specific Suv39h1 knockout ameliorates high-fat diet induced diabetic cardiomyopathy via regulating Hmox1 transcription.
Sun K, Chen M, Kong X, Hou W, Xu Z, Liu L
Life sciences 2025 Jan 1;360:123258
Life sciences 2025 Jan 1;360:123258
LC3B-regulated autophagy mitigates zinc oxide nanoparticle-induced epithelial cell dysfunction and acute lung injury.
Chen R, Luo S, Zhang Y, Mao L, Diao J, Cheng S, Zou Z, Chen C, Qin X, Jiang X, Zhang J
Toxicological sciences : an official journal of the Society of Toxicology 2025 Jan 1;203(1):105-117
Toxicological sciences : an official journal of the Society of Toxicology 2025 Jan 1;203(1):105-117
Loss of Urat1 exacerbates APAP-induced liver injury in mice.
Zhao K, Zhang S, Tian J, Wu S, Chen Y, Wu Z, Liang J, Wu H, Pang J, Wu T
Toxicology 2025 Feb;511:154070
Toxicology 2025 Feb;511:154070
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.
Shi Y, Hong R, Fan Z, Huan R, Gao Y, Ma M, Liu T, Pan C
Toxicology 2025 Feb;511:154067
Toxicology 2025 Feb;511:154067
Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota.
Yang Q, He WH, Xie L, Chen T, Liu RF, Hu JJ, Guo JY, Tan GZ, Wu FL, Gu P, Chen P, Chen Y
Acta pharmacologica Sinica 2025 Feb;46(2):416-429
Acta pharmacologica Sinica 2025 Feb;46(2):416-429
Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF-1α Signaling Pathway.
Zhou J, Lei Y, Zhang S, Liu Y, Yi D
CNS neuroscience & therapeutics 2025 Feb;31(2):e70233
CNS neuroscience & therapeutics 2025 Feb;31(2):e70233
Novel full-thickness biomimetic corneal model for studying pathogenesis and treatment of diabetic keratopathy.
Cui Z, Li X, Ou Y, Sun X, Gu J, Ding C, Yu Z, Guo Y, Liang Y, Mao S, Ma JH, Chan HF, Tang S, Chen J
Materials today. Bio 2025 Feb;30:101409
Materials today. Bio 2025 Feb;30:101409
Melatonin alleviates oxidative stress and inflammation of Leydig cells of Min pig through SIRT1 pathway.
Chen Y, Tang Y, Liu B, Wang J, Wang H, Li B, Liu S, Adeniran SO, Zheng P
Theriogenology 2025 Feb;233:112-122
Theriogenology 2025 Feb;233:112-122
Engineered Bacillus subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters the colon microbiota in a mouse model.
Li W, Wang X, Chen K, Zhu Y, Yang G, Jin Y, Wang J
Veterinary research 2025 Feb 8;56(1):35
Veterinary research 2025 Feb 8;56(1):35
Retinal Protective Effect of Mono-Ethyl Fumarate in Experimental Age-Related Macular Degeneration via Anti-Oxidative and Anti-Apoptotic Alterations.
Lee H, Zhang S, Ahn HR, Kim T, Kim J, Lee H, Jung SH, Kim J
International journal of molecular sciences 2025 Feb 7;26(4)
International journal of molecular sciences 2025 Feb 7;26(4)
Fraxin inhibits ovariectomized-induced bone loss and osteoclastogenesis by suppressing ROS activity.
Zhou H, Chen P, Zhao C, Zou S, Wu H, Huang C, Hu H, Wu Q, Zhang C, Weng W
International immunopharmacology 2025 Feb 6;147:113871
International immunopharmacology 2025 Feb 6;147:113871
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
Huo JL, Fu W, Feng Q, Pan S, Liu D, Liu Z
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury.
Zeng L, Wang Y, Huang Y, Yang W, Zhou P, Wan Y, Tao K, Li R
Cell communication and signaling : CCS 2025 Feb 5;23(1):63
Cell communication and signaling : CCS 2025 Feb 5;23(1):63
Pectin-Zein-IPA nanoparticles promote functional recovery and alleviate neuroinflammation after spinal cord injury.
Chen X, Wang B, Al Mamun A, Du K, Wang S, Hu Q, Chen X, Lu Y, Du A, Wu Y, Shao J, Wang S, Jiang C, Zhou K, Hu S, Xiao J
Journal of nanobiotechnology 2025 Feb 28;23(1):152
Journal of nanobiotechnology 2025 Feb 28;23(1):152
Bifidobacterium bifidum reduces oxidative stress and alters gut flora to mitigate acute liver injury caused by N-acetyl-p-aminophenol.
Yin J, Chen L, Lin Y, Qiu J, Liu F, Wang Y, Dou X
BMC microbiology 2025 Feb 25;25(1):87
BMC microbiology 2025 Feb 25;25(1):87
Scopoletin alleviates acetaminophen-induced hepatotoxicity through modulation of NLRP3 inflammasome activation and Nrf2/HMGB1/TLR4/NF-κB signaling pathway.
Yuan Y, Zhang J, Li H, Yuan F, Cui Q, Wu D, Yuan H, Piao G
International immunopharmacology 2025 Feb 20;148:114132
International immunopharmacology 2025 Feb 20;148:114132
Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells.
Wang X, Zhang T, Wang S, Shi H, Dong H, Huang Y, Lai W, Hu Y, Yue C
Journal of nanobiotechnology 2025 Feb 19;23(1):121
Journal of nanobiotechnology 2025 Feb 19;23(1):121
Brown Algae Polysaccharides Alleviate Diquat-Induced Oxidative Stress in Piglets and IPEC-J2 Cells via Nrf2/ARE Signaling Pathway.
Hou C, Yu Z, Shi C, Huang Y, Liu H
Animals : an open access journal from MDPI 2025 Feb 14;15(4)
Animals : an open access journal from MDPI 2025 Feb 14;15(4)
Analysis of ferroptosis-related genes in cerebral ischemic stroke via immune infiltration and single-cell RNA-sequencing.
Fan W, Zheng J, Jiang F
BMC medical genomics 2025 Feb 11;18(1):31
BMC medical genomics 2025 Feb 11;18(1):31
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis.
Shi J, Chen L, Wang X, Ma X
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 10;74(1):35
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Feb 10;74(1):35
PANAXADIOL SAPONIN ALLEVIATES LPS-INDUCED CARDIOMYOPATHY SIMILAR TO DEXAMETHASONE VIA IMPROVING MITOCHONDRIAL QUALITY CONTROL.
Yang Z, Gao Y, Li D, Zhao L, Du Y
Shock (Augusta, Ga.) 2025 Feb 1;63(2):282-291
Shock (Augusta, Ga.) 2025 Feb 1;63(2):282-291
Transcranial alternating current stimulation inhibits ferroptosis and promotes functional recovery in spinal cord injury via the cGMP-PKG signalling pathway.
Huang K, Fang J, Xiao S, Wang W, Zhang G, Sun W, Shuai L, Bi H
Life sciences 2025 Feb 1;362:123341
Life sciences 2025 Feb 1;362:123341
Luteolin Inhibits Ferroptosis of HUVEC by Regulating the Sirt1/Nrf2 Pathway.
Xiang M, Lin X, Chen H
Cell biochemistry and biophysics 2025 Dec;83(4):5127-5140
Cell biochemistry and biophysics 2025 Dec;83(4):5127-5140
Alpha Ketoglutaric Acid attenuates LPS Induced Inflammatory Response by Inhibiting the PKCε/MAPK/P65 Signaling Pathway and Inhibit Oxidative Stress in Kupffer Cells.
Li Y, Kuang H, Fan G, Yang X
Inflammation 2025 Dec;48(6):4020-4030
Inflammation 2025 Dec;48(6):4020-4030
SIRT6 Overexpression Enhances Diabetic Foot Ulcer Healing via Nrf2 Pathway Activation.
Wei L, Kang M, Zhang G, Meng Y, Qin H
Inflammation 2025 Dec;48(6):3858-3877
Inflammation 2025 Dec;48(6):3858-3877
Screening Hub Genes of Ferroptosis in Pb-Induced Acute Kidney Injury Based on GEO Database Bioinformatics and Experimental Validation.
Fang X, Gao S, Zhang L, Gao J, Li T, Wang C, Xu J, Li C, Lu R, Guo L
Journal of applied toxicology : JAT 2025 Dec;45(12):2688-2699
Journal of applied toxicology : JAT 2025 Dec;45(12):2688-2699
Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis.
Amona FM, Pang Y, Chen X, Liu Z, Su C, Yang J, Liu K, Wu Q, Liu B, Chen X, Zhang C
Materials today. Bio 2025 Dec;35:102491
Materials today. Bio 2025 Dec;35:102491
Nanocomposite-loaded hybrid microneedles reshape dermal microenvironment through senolytic delivery and collagen XVII-mediated barrier repair.
Yang F, Xiong Y, Chen S, Bie F, Li Z, Liu H, Liu L, Zhang Z, Chen L
Materials today. Bio 2025 Dec;35:102410
Materials today. Bio 2025 Dec;35:102410
Integrating superlubricative nanomaterials with precision drug delivery for advanced osteoarthritis therapy.
Gan X, Li J, Li S, Wang X, Wang Q, Chen X, Huang Y, Nie M, Kang H, Dai H
Materials today. Bio 2025 Dec;35:102359
Materials today. Bio 2025 Dec;35:102359
A H(2)-bioreactor for mitochondrial rehabilitation in infected bone defects regeneration.
Kong C, Si C, Liu H, Wang Y, Qiao J, Tang X, Sun H, Zhang J, Chang B
Materials today. Bio 2025 Dec;35:102295
Materials today. Bio 2025 Dec;35:102295
ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling.
Liu X, Chen C, Zhu S, Luo X, Gao L, Hu Z, Ma Y, Jiang L, Wu Y
Redox report : communications in free radical research 2025 Dec;30(1):2529618
Redox report : communications in free radical research 2025 Dec;30(1):2529618
Docosahexaenoic acid ameliorates autistic-like behaviors by inhibiting oxidative stress and inflammatory response in neonatal maternal separation rats.
Xu B, Yuan H, Li X, Yu Q, Dai C, Dong Z
Pediatric discovery 2025 Dec;3(4):e91
Pediatric discovery 2025 Dec;3(4):e91
Astragalus Polysaccharide Enhances O-GlcNAcylation Through OGT to Improve Intervertebral Disc Degeneration in Rats.
Tan H, Fang C, Tan Y, Wang Z, Zhou Y, Li X
Journal of cellular and molecular medicine 2025 Dec;29(23):e70940
Journal of cellular and molecular medicine 2025 Dec;29(23):e70940
Overexpression of cholesterol 24-hydroxylase CYP46A1 attenuates retinal dysfunction and ganglion cell loss via regulating the Nrf2 pathway in optic nerve crush injury.
Long Z, Zhang J, Feng J, He T
Experimental eye research 2025 Dec;261:110649
Experimental eye research 2025 Dec;261:110649
Activation of the Nrf2/HO-1/GPX4 pathway by cGAMP Mitigates oxidative stress and ferroptosis in ischaemic stroke.
Li X, Qian S, Hou Z, Yang G, Ma Y, Gao Y, Zhang Y, Li T
Biochemical pharmacology 2025 Dec;242(Pt 2):117334
Biochemical pharmacology 2025 Dec;242(Pt 2):117334
ABI3BP deficiency alleviates Ang II-induced VSMC senescence through the Nrf2 signalling pathway.
Mao A, Tu Q, Xie H, Wang X, Liu Y, Ding Y, Cao Z
Mechanisms of ageing and development 2025 Dec;228:112104
Mechanisms of ageing and development 2025 Dec;228:112104
Renal tubular VMP1 protects against acute kidney injury via modulating autophagy and autophagy-independent pathway.
Yang W, Jia M, Zhou F, Zhang M, Qu S, Zeng C, Zhu X, Gu S, Xuan J, Liu Z, Zen K
Autophagy 2025 Dec;21(12):2792-2808
Autophagy 2025 Dec;21(12):2792-2808
The phytochemical arbutin exerts potent anti-Toxoplasma effects through activation of cell-autonomous defense mechanisms while attenuating inflammation.
Liu Z, Ma Y, Xiang Y, Shen Y, Liao L, Zhu X, Shi Z, Wei Y, Kou Y, Wang Y
PLoS neglected tropical diseases 2025 Dec;19(12):e0013815
PLoS neglected tropical diseases 2025 Dec;19(12):e0013815
Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway.
Zhang H, Hu Q, Zhang Y, Yang L, Tian S, Zhang X, Shen H, Shu H, Xie L, Wu D, Zhou L, Wei X, Cheng C, Jiang J, Wang H, Shen C, Kong D, Xu L
Gut microbes 2025 Dec;17(1):2517821
Gut microbes 2025 Dec;17(1):2517821
Adipose-derived mesenchymal stem cell exosomes protect keratinocytes from high-glucose injury by modulating KEAP1/NRF2/HO-1 axis.
Yuan Y, Song S, Xiao Y, Feng R, Li M, Zhang H, Luo L, Wang K, Wang P, Wei L, Zhang Y, Zhang B, Jiang S, Shen K, Guan H, Hu D
Cellular signalling 2025 Dec;136:112172
Cellular signalling 2025 Dec;136:112172
Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR-δ Signaling Pathway.
Zhen Q, Xu Y, Xu Y, Liu X, Zhang Y, Ye D, Han S, Liu S, Zhang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e12599
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e12599
Exploring Functionally Enhanced BLP-Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance.
Wan Y, Hong Y, Ji X, Xiang J, Liu J, Liang L, Ren M, Chen W, Xu T, Li Z, Shi T, Jiang Y, Liang H, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e17142
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e17142
Mesenchymal stem cells' exosomes alleviate chronic visceral pain through Nrf-2-mediated oxidative stress pathway in rats.
Liu Y, Li M, Lian X, Chen X, Lin C, Jin L, You J, Lai Y, Liu L, Zhu Y, Lin J
Pain reports 2025 Dec;10(6):e1372
Pain reports 2025 Dec;10(6):e1372
Investigating Nickel-Induced Neurotoxicity: Associations with Gut Microbiota Dysbiosis and Ferroptosis.
Shen Y, Cao K, Zhang W, Chen C, Gao C, Wang J, Xin T, Li C, Tang S, Pei X, Li D
Antioxidants (Basel, Switzerland) 2025 Dec 9;14(12)
Antioxidants (Basel, Switzerland) 2025 Dec 9;14(12)
Functional nano-nucleic acid platform promotes copper-induced gastric cancer cell death.
Zhang H, Ding B, Kou Q
RSC advances 2025 Dec 8;15(57):49643-49651
RSC advances 2025 Dec 8;15(57):49643-49651
Heterogeneity of active mast cells, endothelial cells, and fibroblasts in hemophilic arthritis defined by synovial single-cell sequencing.
Lin K, Fan S, Yang X, Hou W, Zhang J, Liao J, Han L, Peng P, Xiao F, Fang W, He X, Tian J, Lu S, Yang F, Wei Q, He M
Scientific reports 2025 Dec 8;15(1):43350
Scientific reports 2025 Dec 8;15(1):43350
Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.
Xiufang L, Zhongqing W, Huidan W, Ye Z, Xu H, Wei C, Haicui W, Fang L
Journal of ovarian research 2025 Dec 30;19(1):37
Journal of ovarian research 2025 Dec 30;19(1):37
Sofalcone inhibits osteoclastogenesis through Keap1/Nrf2 signaling activation and mitigates ovariectomy-induced bone loss.
Liang H, Wu Q, Hua T, Chen Y, Luo J, Miao J, Su H, Yang S, Xu J, Wang X, Jin H
International immunopharmacology 2025 Dec 3;166:115589
International immunopharmacology 2025 Dec 3;166:115589
Selenium improves behavioral performance in a rat model of autism spectrum disorder by mitigating oxidative stress and modulating the Sirt1/Keap1/Nrf2/HO-1 signaling pathway.
Shu Y, Yang J, Zhang P, Zhang X, Zhao X, Yan J, Zhang B, Du J
International immunopharmacology 2025 Dec 3;166:115556
International immunopharmacology 2025 Dec 3;166:115556
TCF3 activates super-enhancer-driven TRIB2 overexpression to suppress ferroptosis and promote hepatoblastoma proliferation.
Wu H, Zhu G, Zhu Q, Ma J, Mao S, Ding M, Zhu J, Tang X, Bian Z, Shan Y, Gu S, Sun F, Jiang C, Pan Q
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
Journal of experimental & clinical cancer research : CR 2025 Dec 29;44(1):329
Butin inhibits osteoarthritis progression by modulating the Nrf2/HO-1 signaling pathway and inhibiting NF-κB signaling.
Zhou P, Chang J, Wei X, Zhu C, Yang J, Wang C, Hu Y, Zhang C
Scientific reports 2025 Dec 26;15(1):45688
Scientific reports 2025 Dec 26;15(1):45688
Microneedle Patch Delivering Multifunctional Melanin-like Nanoparticles for Vitiligo Remission and Repigmentation.
Jiang Z, Zhou Y, Wang B, He C, Zhang J, Wang Q, Deng Z, Li C, Jian Z
ACS applied materials & interfaces 2025 Dec 24;17(51):68894-68909
ACS applied materials & interfaces 2025 Dec 24;17(51):68894-68909
Vitisin A inhibits liver fibrosis by promoting Nrf2/HO-1 pathway and inhibiting Cuproptosis.
Ding S, Hu D, Pan Y, Wang J, Wang L
Scientific reports 2025 Dec 19;15(1):44186
Scientific reports 2025 Dec 19;15(1):44186
Expression and Biological Activity of Recombinant Type IV Collagen.
Chang Y, Zhang Z, Yuwen W, Xu R, Fu R, Zhu C, Li W, Duan Z, Fan D
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31865-31877
Journal of agricultural and food chemistry 2025 Dec 17;73(50):31865-31877
The Neuroprotective Effect of 4-Octyl Itaconate on Acute Period of Experimental Autoimmune Neuritis.
Zhang LJ, Zhao N, Li J, Zhai H, Wu J, Yang L
Inflammation 2025 Dec 17;49(1):5
Inflammation 2025 Dec 17;49(1):5
Synergistic Proteolysis Targeting Chimera Chemotherapy Conjugate for Potent Non-small Cell Lung Cancer Treatment.
Zhao Q, Zeng R, Bi T, Yang X, Wang T, Chen L, Huang J, Dai X, Xu H, Sun Q, Liu Z
ACS applied materials & interfaces 2025 Dec 17;17(50):67595-67608
ACS applied materials & interfaces 2025 Dec 17;17(50):67595-67608
MOTS-c attenuates mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via an Nrf2-Dependent Mechanism.
Li K, Yang T, Chen F, Lou C, Chen Y, Chen Z, Ye L, Sun X, Liu G, Xie C, Fang J, Hu X, Zhu Y, Liu B, He D, Ma H
Free radical biology & medicine 2025 Dec 16;241:717-731
Free radical biology & medicine 2025 Dec 16;241:717-731
The FAK-NRF2 Axis Alleviates DOX-Induced Cardiotoxicity by Inhibiting Ferroptosis.
Zhao Y, Chen M, Kong L, Wu S, Teng C, Hu S, Xie K, Du J, Zhu X, Wang P, Xu P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71289
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 15;39(23):e71289
Cepharanthine alleviates lipopolysaccharide-induced acute lung injury through modulating macrophage polarization.
Dang L, He B, Yang J, Liu J, Ding Y, Xin W
Scientific reports 2025 Dec 1;16(1):538
Scientific reports 2025 Dec 1;16(1):538
Competitive Binding of Pseudomonas aeruginosa to Kelch-Like ECH-Associated Protein 1 Inhibits Nuclear Factor Erythroid 2-Related Factor 2 Ubiquitination and Suppresses Ferroptosis in Macrophages.
Zhu Y, Liu Q, Lu E, Li Z
Microbiology and immunology 2025 Aug;69(8):418-428
Microbiology and immunology 2025 Aug;69(8):418-428
Arbutin Preserves Boar Sperm During Storage at 17°C by Enhancing the Antioxidant Capacity via the NRF2/GPX4 Signalling.
Liu W, Li W, Lin R, Wang Y, Zhou P, Pang W, Li R, Zheng Y
Reproduction in domestic animals = Zuchthygiene 2025 Aug;60(8):e70103
Reproduction in domestic animals = Zuchthygiene 2025 Aug;60(8):e70103
Major Ozonated Autoheamotherapy Alleviates Skeletal Muscle Ischemia/Reperfusion Injury by Regulating Nrf2/HO-1 Pathway.
Guo HZ, Yu SL, Chen HW
The Kaohsiung journal of medical sciences 2025 Aug;41(8):e70039
The Kaohsiung journal of medical sciences 2025 Aug;41(8):e70039
Ethanol extract of Sauropus spatulifolius and its active constituents attenuate LPS-induced acute lung injury via NF-κB inhibition and Nrf2 activation.
Zhao L, Du L, Li Y, Guo Y, Pei D, Zhu D, Zhang H
Food science and biotechnology 2025 Aug;34(12):2947-2957
Food science and biotechnology 2025 Aug;34(12):2947-2957
The role of FAK in renal collecting duct in the progression from acute kidney injury to chronic kidney disease.
Gao C, He J, Wang Y, Shao G, Lin S, Liu J, Ren C, Quan Y, Ying Y, Li M, Yang B, Zhou H
Translational research : the journal of laboratory and clinical medicine 2025 Aug;282:41-55
Translational research : the journal of laboratory and clinical medicine 2025 Aug;282:41-55
Ergothioneine alleviates osteoporosis via the ROS-MAPK signaling Axis.
Guo Z, Huang Y, Wang X, Han Y, Li A, Qu Y, Chen L, Du M, Zhang Y, Xu Y
Bone 2025 Aug;197:117496
Bone 2025 Aug;197:117496
Chemical knockdown of Keap1 and homoPROTAC-ing allergic rhinitis.
Yan J, Wang T, Yu R, Xu L, Shao H, Li T, Wang Z, Cha X, Miao Z, Xing C, Xu K, Liu H, Zhuang C
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4137-4155
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4137-4155
NIR Driven Pd/Cerium Oxide Nano-Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy.
Qin T, Qin L, Zhao Y, Chen Y, Liu Q, Lin X, Lan Y, Huang Y, Liu Y, Zhang K, Pan L, Li J, Duan K, Liang H, Yin M, Fan G, Liu L, Deng Y, Liao L, Su D, Gao M, Lu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e17252
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(32):e17252
Butyrate protects against myocardial ischemia injury and cardiomyocyte pyroptosis by inhibiting MALT1-mediated Nrf2 ubiquitination and degradation.
Zhang P, Su Y, Cheng Y
Journal of molecular histology 2025 Aug 8;56(4):261
Journal of molecular histology 2025 Aug 8;56(4):261
T-2 Toxin-Induced Hepatotoxicity in HepG2 Cells Involves the Inflammatory and Nrf2/HO-1 Pathways.
Taroncher M, Franco-Campos F, Rodríguez-Carrasco Y, Ruiz MJ
Toxins 2025 Aug 8;17(8)
Toxins 2025 Aug 8;17(8)
Atractylenolide III alleviates amyloid-β-induced cognitive impairments in mice.
Yuan H, Xia L, Li J, Dai C, Li X, Xu B, Xue M, Shi X, Wu B, Dong Z, Pang Y
Molecular biology reports 2025 Aug 7;52(1):799
Molecular biology reports 2025 Aug 7;52(1):799
An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer.
Bahri M, Al-Adhami T, Demirel E, Sarkar J, Feehan KT, Anstee JE, Cheung TS, Sosnowska D, Woodman CA, Macmorland W, Yang DD, Rosekilly J, Gitsaki-Taylor R, Gillett CE, Scudamore CL, Spicer J, Rahman KM, Arnold JN
Science translational medicine 2025 Aug 6;17(810):eads3085
Science translational medicine 2025 Aug 6;17(810):eads3085
Discovery of a CYP2E1 inhibitor and its therapeutic potential in severe acute pancreatitis.
Qiu J, Lu J, Wang X, Zhang Y, Guo M, Guo F, Xu H, Qiao H
European journal of medicinal chemistry 2025 Aug 5;292:117666
European journal of medicinal chemistry 2025 Aug 5;292:117666
Effect of the DPP4 Inhibitor Sitagliptin on Ferroptosis in Epilepsy.
Hou B, Li L, Wang F, Guo J
Journal of integrative neuroscience 2025 Aug 28;24(8):39469
Journal of integrative neuroscience 2025 Aug 28;24(8):39469
Tumor microenvironments with an active type I IFN response are sensitive to inhibitors of heme degradation.
Sosnowska D, Cheung TS, Sarkar J, Opzoomer JW, Feehan KT, Anstee JE, Woodman CA, Keddar MR, Clayton K, Ali S, Macmorland W, Yang DD, Rosekilly J, Gillett CE, Ciccarelli FD, Buus R, Spicer J, Grigoriadis A, Arnold JN
JCI insight 2025 Aug 22;10(16)
JCI insight 2025 Aug 22;10(16)
The endoplasmic reticulum stress-ferroptosis reciprocal signaling orchestrates anti-tumor effect of anlotinib in anaplastic thyroid cancer.
Guo Y, Liang J, Ding L, Wu J, Teng W, Wang J, Jiang L, Tan Z
Cancer cell international 2025 Aug 21;25(1):310
Cancer cell international 2025 Aug 21;25(1):310
Isolation and identification of a new porcine astrovirus 5 demonstrated that oxidative stress enhances porcine astrovirus replication.
Du Y, Qin Y, Feng X, Luo Y, Lv Y, Song S, Wei X, Ouyang K, Yin Y, Chen Y, Wei Z, Huang W, Qin Y
BMC veterinary research 2025 Aug 19;21(1):518
BMC veterinary research 2025 Aug 19;21(1):518
Luteolin attenuates trimethyltin chloride-induced hippocampal neurotoxicity through SIRT3/NRF2/HO-1 activation.
Ding N, Wang P, Fang Y, Hu Y, Wang W, Wei J, Yu J, Cai F
Neuropharmacology 2025 Aug 15;274:110461
Neuropharmacology 2025 Aug 15;274:110461
Development of Hydrogen Sulfide-Donating Silybin Derivatives with a Type-2 Diabetes Mellitus-Alleviating Effect through Improving Intestinal L-Cell Functions.
Li H, Ma Q, Li X, Zheng C, Lin L, Gu J, Huang X, Yang H, Xu H, Xu F, Hua H, Cheng M, Li D
Journal of medicinal chemistry 2025 Aug 14;68(15):15520-15542
Journal of medicinal chemistry 2025 Aug 14;68(15):15520-15542
Effect of ultrasound-microbubble exposure on acute myeloid leukemia cancer cell proteome.
Stilwell J, Savaya DA, Sakarya E, Ferworn C, Cloves E, Botelho RJ, Antonescu CN, Karshafian R
Scientific reports 2025 Aug 14;15(1):29817
Scientific reports 2025 Aug 14;15(1):29817
Dental pulp stem cells derived exosomes inhibit ferroptosis via regulating the Nrf2-keap1/GPX4 signaling pathway to ameliorate chronic kidney disease injury.
Luo L, Wang J, Zhao J, Yang B, Ma W, Lin J
Tissue & cell 2025 Apr;93:102670
Tissue & cell 2025 Apr;93:102670
β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.
Chen L, Zeng L, Pan S, Zu L, Pan H, Fan L
Cytotechnology 2025 Apr;77(2):76
Cytotechnology 2025 Apr;77(2):76
FGF21 Alleviates Hypoxic-Ischemic White Matter Injury in Neonatal Mice by Mediating Inflammation and Oxidative Stress Through PPAR-γ Signaling Pathway.
Fang M, Lu L, Lou J, Ou J, Yu Q, Tao X, Zhu J, Lin Z
Molecular neurobiology 2025 Apr;62(4):4743-4768
Molecular neurobiology 2025 Apr;62(4):4743-4768
Evidence that a Novel Chalcone Derivative, Compound 27, Acts on the Epithelium Via the PI3K/AKT/Nrf2-Keap1 Signaling Pathway, to Mitigate LPS-Induced Acute Lung Injury in Mice.
Zhou L, Lin Y, Zhou T, Xue Y, Bellusci S, Shen M, Chen C, Chen C
Inflammation 2025 Apr;48(2):590-606
Inflammation 2025 Apr;48(2):590-606
Acute hyperglycemia impedes spinal cord injury recovery via triggering excessive ferroptosis of endothelial cells.
Wu M, Zhang S, Wu X, Zhou Y, Zhou M, Du A, Zhang Y, Wei T, Wang B, Wang S, Jiang C, Hu S, Xiao J, Wu Y
International journal of biological macromolecules 2025 Apr;301:140453
International journal of biological macromolecules 2025 Apr;301:140453
Chlorogenic acid mitigates heat stress-induced oxidative damage in bovine mammary epithelial cells by inhibiting NF-κB-mediated NLRP3 inflammasome activation via upregulating the Nrf2 signaling pathway.
Huang Q, Shan Q, Ma F, Li S, Sun P
International journal of biological macromolecules 2025 Apr;301:140133
International journal of biological macromolecules 2025 Apr;301:140133
Sagittaria sagittifolia polysaccharide extract regulates Nrf2 to improve endoplasmic reticulum stress-mediated apoptosis in rat cataracts and HLEB3 cells.
Zhou MY, Liu BQ, Gao X, Zhang SJ, Jiang Y, Yang T, Sun JB, Zhang X, Liao Y
International journal of biological macromolecules 2025 Apr;300:140270
International journal of biological macromolecules 2025 Apr;300:140270
Chlorogenic acid improves SPS-induced PTSD-like behaviors in rats by regulating the crosstalk between Nrf2 and NF-κB signaling pathway.
Tang C, Gao J, Li S, Cheng H, Peng YY, Ding Y, Yang H, Ma XM, Wang HY, Long ZY, Lu XM, Wang YT
Free radical biology & medicine 2025 Apr;231:136-152
Free radical biology & medicine 2025 Apr;231:136-152
Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8(+) T cells for triple-negative breast cancer therapy.
Yang T, Liu Z, Fu Z, Zhang X, Cao Y, Liang Q, Miao J, Yang H, Zhang T, Hei J, Ni W, Liu Y
Asian journal of pharmaceutical sciences 2025 Apr;20(2):100970
Asian journal of pharmaceutical sciences 2025 Apr;20(2):100970
In vivo and In vitro assessment of the retinal toxicity of polystyrene nanoplastics.
Zheng J, He L, Shi Q, Wang M, Ma Y, Yu W, Liu L, Yu G, Liu X, Wang B, Zhong J
Environment international 2025 Apr;198:109420
Environment international 2025 Apr;198:109420
Magnesium isoglycyrrhizinate prevented the liver injury of acetaminophen by promoting mitochondrial biogenesis.
Xia S, Hu ZY, Cao R, Guo L, Ma JT, Xiao MX, Liu J, Zhai BW, Fu R, Jiang ZC, Gong H, Yan M
Toxicology research 2025 Apr;14(2):tfaf024
Toxicology research 2025 Apr;14(2):tfaf024
Smilax glabra roxb. alleviates cisplatin-induced acute kidney injury in mice by activating the Nrf2/HO-1 Signalling Pathway.
Zhao L, Yue Z, Wang G, Qin J, Ma H, Tang D, Yin G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156550
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156550
Baicalin Ameliorates L-Glutamate-Induced Hippocampal Oxidative Stress Injury and Apoptosis in Mice by Regulating Nrf2/HO-1 Signalling Pathway.
Li F, Huang Z, Gou H, Zheng J, Yao M
Basic & clinical pharmacology & toxicology 2025 Apr;136(4):e70024
Basic & clinical pharmacology & toxicology 2025 Apr;136(4):e70024
A novel histone deacetylase inhibitor protects the blood-brain barrier by regulating NF-κB and Nrf2 signaling pathways in OGD/R injury.
Ling L, Zhou G, Zhang X, Mao B, Wan S, Bao Y
Archives of gerontology and geriatrics 2025 Apr;131:105739
Archives of gerontology and geriatrics 2025 Apr;131:105739
Inhibition of MALAT1 facilitates ROS accumulation via the Keap1/HO-1 pathway to enhance photodynamic therapy in secondary hyperparathyroidism.
Wen Y, Li Y, Zhang D, Liu Z, Liu H, Li X, Wu W, Zeng L, Zou Q, Yi W
Non-coding RNA research 2025 Apr;11:249-261
Non-coding RNA research 2025 Apr;11:249-261
Tanshinone IIA Ameliorates Myocardial Ischemia-Reperfusion Injury via Activating HDAC1-Repressed Nrf2-xCT/Gpx4/HO-1 Axis.
Yan K, Yu S, Gao X, Li L, Ding L
Chemical biology & drug design 2025 Apr;105(4):e70095
Chemical biology & drug design 2025 Apr;105(4):e70095
The Antioxidant Effect of Selenium Is Enhanced by Cortisol Through Nrf2 Pathway in Bovine Endometrial Epithelial Cells.
Cui L, Zhong J, Duan J, Li W, Mao P, Dong J, Liu K, Guo L, Wang H, Li J
Animals : an open access journal from MDPI 2025 Apr 8;15(8)
Animals : an open access journal from MDPI 2025 Apr 8;15(8)
HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.
Peng X, Sun B, Tang C, Shi C, Xie X, Wang X, Jiang D, Li S, Jia Y, Wang Y, Tang H, Zhong S, Piao M, Cui X, Zhang S, Wang F, Wang Y, Na R, Huang R, Jiang Y, Zhang W, Xu J, Lin K, Guo J, Pan Z, Wang K, Zhao Q, Liu H, Yu B, Ji Y, Zhang J, Li S, Tian J
Developmental cell 2025 Apr 7;60(7):1070-1086.e8
Developmental cell 2025 Apr 7;60(7):1070-1086.e8
RAGE deficiency obstructs high uric acid-induced oxidative stress and inflammatory response.
Zhao H, Lv J, Chen B, He F, Wang Q, Xie D, Koyama H, Zhang C, Cheng J
International immunopharmacology 2025 Apr 4;151:114316
International immunopharmacology 2025 Apr 4;151:114316
Morinda officinalis Oligosaccharides Protect Against LPS-Induced Uterine Damage and Endometrial Inflammation in Mice and Bovine Endometrial Epithelial Cells.
He S, Yu B, Yu T, Jiang T, Yang D, Peng H
Animals : an open access journal from MDPI 2025 Apr 30;15(9)
Animals : an open access journal from MDPI 2025 Apr 30;15(9)
Self-targeted nanosystem for enhanced chemodynamic cancer therapy.
Asif K, Rahman MM, Canzonieri V, Caligiuri I, Rizzolio F, Adeel M
Biomaterials science 2025 Apr 29;13(9):2320-2331
Biomaterials science 2025 Apr 29;13(9):2320-2331
Effects of Acrylamide on Mouse Implantation and Decidualization.
Yang HY, Luo HN, Wang ZM, Jin DD, Yang ZM
International journal of molecular sciences 2025 Apr 26;26(9)
International journal of molecular sciences 2025 Apr 26;26(9)
Synergistic Antioxidant and Anti-Ferroptosis Therapy via BPNS-Encapsulated Thermoresponsive Chitosan Hydrogel for Spinal Cord Injury Regeneration.
Liu Y, Wang Y, Wang X, Zeng W, Zhang Z, Zhang Z, Qi Z
Pharmaceutics 2025 Apr 26;17(5)
Pharmaceutics 2025 Apr 26;17(5)
Lactiplantibacillus plantarum -derived extracellular vesicles alleviate acute lung injury by inhibiting ferroptosis of macrophages.
Zhao Q, Lai J, Jiang Y, Cui E, Chang H, Pan R, Li P, Shao JZ, Zheng J, Chen Y
Journal of nanobiotechnology 2025 Apr 23;23(1):307
Journal of nanobiotechnology 2025 Apr 23;23(1):307
Regulation of the Nrf2/HO-1 pathway in chronic obstructive pulmonary disease-induced muscle atrophy using Jinshui Liujian decoction and Bajitian pills: insights from network pharmacology and animal models.
Lin BY, Bai L, Wang SL
Hereditas 2025 Apr 21;162(1):66
Hereditas 2025 Apr 21;162(1):66
Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity.
Wang F, Amona FM, Pang Y, Zhang Q, Liang Y, Chen X, Ke Y, Chen J, Song C, Wang Y, Li Z, Zhang C, Fang X, Chen X
Journal of virology 2025 Apr 15;99(4):e0158524
Journal of virology 2025 Apr 15;99(4):e0158524
3,4-Dimethoxychalcone alleviates limb ischemia/reperfusion injury by TFEB-mediated autophagy enhancement and antioxidative response.
Qiu YH, Zhang YH, Wu ZC, Huang JY, Chen BC, Xiao J, Chen FF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70496
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Apr 15;39(7):e70496
Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.
Zhao Z, Lu H, Wang J, Wu T, Xu S, Ge Y, You Q, Jiang Z, Lu M
European journal of medicinal chemistry 2025 Apr 15;288:117384
European journal of medicinal chemistry 2025 Apr 15;288:117384
Mechanism of dracorhodin in accelerating diabetic foot ulcer healing via the Nrf2 pathway, a network pharmacology, molecular docking and experimental validation.
Tang G, Wang Y, Deng P, Wu J, Lu Z, Zhu R, Guo H, Zhang Y, Mo X, Chen Z
Scientific reports 2025 Apr 11;15(1):12492
Scientific reports 2025 Apr 11;15(1):12492
Krill Oil Ameliorates Liver Injury in Diabetic Mice by Activating Antioxidant Capacity and Inhibiting Ferroptosis.
Meng H, Li J, Yang Y, Zheng Y, Wang S, Guo X, Du L, Wu H
Journal of oleo science 2024;73(8):1069-1082
Journal of oleo science 2024;73(8):1069-1082
Cytotoxicity and inhibitory potential of CUDC-101 in non-small cell lung cancer cells with rare EGFR L861Q mutation.
Chu C, Xu H, Liu C, Wei X, Li L, Wang R, Cui W, Zhang G, Liu C, Wang K, An L, He F
Current research in toxicology 2024;7:100194
Current research in toxicology 2024;7:100194
Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway.
Gong D, Dong Z, Chen X, Chen H, Lin H
Acta cirurgica brasileira 2024;39:e396124
Acta cirurgica brasileira 2024;39:e396124
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
Xiang C, Lu Y, Hao R, Wei Y, Hu Y, Yu G
Iranian journal of basic medical sciences 2024;27(12):1547-1557
Iranian journal of basic medical sciences 2024;27(12):1547-1557
The PI3K/Akt-Nrf2 Signaling Pathway and Mitophagy Synergistically Mediate Hydroxytyrosol to Alleviate Intestinal Oxidative Damage.
Wen X, Tang S, Wan F, Zhong R, Chen L, Zhang H
International journal of biological sciences 2024;20(11):4258-4276
International journal of biological sciences 2024;20(11):4258-4276
Benfotiamine protects MPTP-induced Parkinson's disease mouse model via activating Nrf2 signaling pathway.
Wang K, Han C, Yang J, Xu W, Wang L, Li H, Wang Y
PloS one 2024;19(7):e0307012
PloS one 2024;19(7):e0307012
Therapeutic potential of salidroside in type I diabetic erectile dysfunction: Attenuation of oxidative stress and apoptosis via the Nrf2/HO-1 pathway.
Li Z, Jia B, Guo Z, Zhang K, Zhao D, Li Z, Fu Q
PloS one 2024;19(7):e0306926
PloS one 2024;19(7):e0306926
Antioxidant Carbon Dots and Ursolic Acid Co-Encapsulated Liposomes Composite Hydrogel for Alleviating Adhesion Formation and Enhancing Tendon Healing in Tendon Injury.
Peng C, Kang S, Jiang M, Yang M, Gong X
International journal of nanomedicine 2024;19:8709-8727
International journal of nanomedicine 2024;19:8709-8727
Dual-Stimuli-Responsive Gut Microbiota-Targeting Nitidine Chloride-CS/PT-NPs Improved Metabolic Status in NAFLD.
Lu J, Zeng Y, Zhong H, Guo W, Zhang Y, Mai W, Qin Y, Su X, Zhang B, Wu W, Zhu Y, Huang Q, Ye Y
International journal of nanomedicine 2024;19:2409-2428
International journal of nanomedicine 2024;19:2409-2428
Artesunate-Nanoliposome-TPP, a Novel Drug Delivery System That Targets the Mitochondria, Attenuates Cisplatin-Induced Acute Kidney Injury by Suppressing Oxidative Stress and Inflammatory Effects.
Zhang J, Gu L, Jiang Y, Ma Y, Zhang Z, Shen S, Shen S, Peng Q, Xiao W
International journal of nanomedicine 2024;19:1385-1408
International journal of nanomedicine 2024;19:1385-1408
The Mechanism of Catalpol to Improve Oxidative Damage of Dermal Fibroblasts Based on Nrf2/HO-1 Signaling Pathway.
Lang X, Xu L, Li L, Feng X
Drug design, development and therapy 2024;18:2287-2297
Drug design, development and therapy 2024;18:2287-2297
Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice.
Wang S, Zhou Y, Wu Y, Lang Y, Mao Y, Pan G, Gao Z
Frontiers in neuroscience 2024;18:1505650
Frontiers in neuroscience 2024;18:1505650
5-Methoxytryptophan Alleviates Lipopolysaccharide-Induced Acute Kidney Injury by Regulating Nrf2-Mediated Mitophagy.
Sun X, Wang H, Liu Y, Yang Y, Wang Y, Liu Y, Ai S, Shan Z, Luo P
Journal of inflammation research 2024;17:9857-9873
Journal of inflammation research 2024;17:9857-9873
Diosgenin derivative ML5 attenuates MPTP-induced neuronal impairment via regulating AMPK/PGC-1α-mediated mitochondrial biogenesis and fusion/fission.
Fan JJ, Ding WD, Liang YF, Wei YX, Huang Y, Ma L, Wang R
American journal of translational research 2024;16(8):3582-3598
American journal of translational research 2024;16(8):3582-3598
NCAPD3-mediated ferroptosis of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation in T47D cells.
Shen J, Zhang S, Song Y, Yang L, Huang Q, Wang P, Zhang Y
Frontiers in pharmacology 2024;15:1531220
Frontiers in pharmacology 2024;15:1531220
Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells.
Hou X, Mao L, Zhang H, Wang L, He B, Guo J, Wang J
Frontiers in pharmacology 2024;15:1509520
Frontiers in pharmacology 2024;15:1509520
β-cryptoxanthin suppresses oxidative stress via activation of the Nrf2/HO-1 signaling pathway in diabetic kidney disease.
Ke J, Zang H, Liu Y, Teng Q, Hua J, Peng D, Wang P
Frontiers in pharmacology 2024;15:1480629
Frontiers in pharmacology 2024;15:1480629
Brozopine ameliorates cognitive impairment via upregulating Nrf2, antioxidation and anti-inflammation activities.
Fu Z, Wang X, Fan Y, Shang D, Zhang J, Xiao T, Guo J, Wang Y, Wang Z, Zhang Z, Jia Q, Zhu J, Jahromi AB, Meng Y, Gao N, Chang J, Gao Y
Frontiers in pharmacology 2024;15:1428455
Frontiers in pharmacology 2024;15:1428455
Li-Hong Tang alleviates dextran sodium sulfate-induced colitis by regulating NRF2/HO-1 signaling pathway and gut microbiota.
Gu H, Tian Y, Xia J, Deng X, Chen J, Jian T, Ma J
Frontiers in pharmacology 2024;15:1413666
Frontiers in pharmacology 2024;15:1413666
LSD1 inhibition by tranylcypromine hydrochloride reduces alkali burn-induced corneal neovascularization and ferroptosis by suppressing HIF-1α pathway.
Deng Q, Gao Y, Wang Y, Mao J, Yan Y, Yang Z, Cong Y, Yang Y, Wan S
Frontiers in pharmacology 2024;15:1411513
Frontiers in pharmacology 2024;15:1411513
FGF21 inhibits ferroptosis caused by mitochondrial damage to promote the repair of peripheral nerve injury.
Yan Y, Ran X, Zhou Z, Gu Y, Wang R, Qiu C, Sun Y, Wang J, Xiao J, Lu Y, Wang J
Frontiers in pharmacology 2024;15:1358646
Frontiers in pharmacology 2024;15:1358646
A novel ferroptosis inhibitor, Thonningianin A, improves Alzheimer's disease by activating GPX4.
Yong Y, Yan L, Wei J, Feng C, Yu L, Wu J, Guo M, Fan D, Yu C, Qin D, Zhou X, Wu A
Theranostics 2024;14(16):6161-6184
Theranostics 2024;14(16):6161-6184
Neuregulin-1, a member of the epidermal growth factor family, mitigates STING-mediated pyroptosis and necroptosis in ischaemic flaps.
Zhu X, Yu G, Lv Y, Yang N, Zhao Y, Li F, Zhao J, Chen Z, Lai Y, Chen L, Wang X, Xiao J, Cai Y, Feng Y, Ding J, Gao W, Zhou K, Xu H
Burns & trauma 2024;12:tkae035
Burns & trauma 2024;12:tkae035
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Xu L, An T, Jia B, Wu Q, Shen J, Jin J, Liu J, Li C
Burns & trauma 2024;12:tkad062
Burns & trauma 2024;12:tkad062
Inhibition effect of copper-bearing metals on arterial neointimal hyperplasia via the AKT/Nrf2/ARE pathway in vitro and in vivo.
Wang P, Xu X, Gu G, Guo Q, Rao Y, Yang K, Xi T, Yuan Y, Chen S, Qi X
Regenerative biomaterials 2024;11:rbae042
Regenerative biomaterials 2024;11:rbae042
Antioxidant and anti-inflammatory injectable hydrogel microspheres for in situ treatment of tendinopathy.
Han Q, Bai L, Qian Y, Zhang X, Wang J, Zhou J, Cui W, Hao Y, Yang X
Regenerative biomaterials 2024;11:rbae007
Regenerative biomaterials 2024;11:rbae007
Myo-inositol improves developmental competence and reduces oxidative stress in porcine parthenogenetic embryos.
Jawad A, Oh D, Choi H, Kim M, Ham J, Oh BC, Lee J, Hyun SH
Frontiers in veterinary science 2024;11:1475329
Frontiers in veterinary science 2024;11:1475329
Low expression of selenoprotein S induces oxidative damage in cartilages.
Cui Y, Liao Y, Chen Y, Zhao X, Zhang Y, Wang H, Li L, Zhang X, Chen K, Jia M, Tian J, Ruan X, Shi Y, Yang P, Chen J
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 Sep;85:127492
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 Sep;85:127492
Changes of m(6)A Regulatory Proteins and Nrf2 Signaling Molecules in Liver Tissue of Type 2 Diabetes Mellitus Rats.
Wang N, Yang J, Liu X, Liu G, He Z, Gu S
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226
Cell biochemistry and biophysics 2024 Sep;82(3):2217-2226
NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.
Wang H, Mao W, Zhang Y, Feng W, Bai B, Ji B, Chen J, Cheng B, Yan F
Free radical biology & medicine 2024 Sep;222:331-343
Free radical biology & medicine 2024 Sep;222:331-343
Butylphthalide inhibits ferroptosis and ameliorates cerebral Ischaemia-Reperfusion injury in rats by activating the Nrf2/HO-1 signalling pathway.
Sun M, Chen J, Liu F, Li P, Lu J, Ge S, Wang L, Zhang X, Wang X
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00444
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00444
Prediction and verification of targets for α-hederin/oxaliplatin dual-loaded rHDL modified liposomes: Reversing effector T-cells dysfunction and improving anti-COAD efficiency in vitro and in vivo.
Wang G, Xu XN, Zhi-Min Z, Wang K, Li F
International journal of pharmaceutics 2024 Sep 5;662:124512
International journal of pharmaceutics 2024 Sep 5;662:124512
Network Analysis of Gut Microbial Communities Reveals Key Reason for Quercetin Protects against Colitis.
Lv Y, Peng J, Ma X, Liang Z, Salekdeh GH, Ke Q, Shen W, Yan Z, Li H, Wang S, Ding X
Microorganisms 2024 Sep 29;12(10)
Microorganisms 2024 Sep 29;12(10)
Aldo-Keto reductase 1C3 reduces myocardial cell damage after acute myocardial infarction by activating the Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2-antioxidant response element pathway to inhibit ferroptosis.
Miao W, Hu YZ
Journal of geriatric cardiology : JGC 2024 Sep 28;21(9):899-912
Journal of geriatric cardiology : JGC 2024 Sep 28;21(9):899-912
A Lysosome-Targeting hNEU1 Inhibitor Treats Myocardial Infarction: A Potential Therapeutic Breakthrough.
Zhou W, Yang W, Jiang P, Gou S
Journal of medicinal chemistry 2024 Sep 26;67(18):16899-16911
Journal of medicinal chemistry 2024 Sep 26;67(18):16899-16911
MMP9 drives ferroptosis by regulating GPX4 and iron signaling.
Gawargi FI, Mishra PK
iScience 2024 Sep 20;27(9):110622
iScience 2024 Sep 20;27(9):110622
Protective role of seleno-amino acid against IBD via ferroptosis inhibition in enteral nutrition therapy.
Huangfu S, Zheng J, He J, Liao J, Jiang H, Zhou H, Pan J
iScience 2024 Sep 20;27(9):110494
iScience 2024 Sep 20;27(9):110494
Salidroside alleviates simulated microgravity-induced bone loss by activating the Nrf2/HO-1 pathway.
Wang N, Zuo Z, Meng T, Liu Y, Zheng X, Ma Y
Journal of orthopaedic surgery and research 2024 Sep 2;19(1):531
Journal of orthopaedic surgery and research 2024 Sep 2;19(1):531
MFSD7C protects hemolysis-induced lung impairments by inhibiting ferroptosis.
Wang H, You X, Wang J, Chen X, Gao Y, Wang M, Zhang W, Zhang J, Yu Y, Han B, Qi M, Liu X, Lou H, Dong T
Nature communications 2024 Sep 19;15(1):8226
Nature communications 2024 Sep 19;15(1):8226
NBQX mediates ventricular fibrillation susceptibility in rat models of anxiety via the Nrf2/HO-1 pathway.
Hu Y, Qu C, Zou Y, Liu X, Zhang C, Yang B
Heliyon 2024 Sep 15;10(17):e37358
Heliyon 2024 Sep 15;10(17):e37358
LFHP-1c improves cognitive function after TBI in mice by reducing oxidative stress through the PGAM5-NRF2-KEAP1 ternary complex.
Shao W, Wang JJ, Niu ZH, Zhang K, Wang S, Wang YH, Tang YH, Wang CC, Hou SQ, Zhou DR, Zhang C, Lin N
Heliyon 2024 Sep 15;10(17):e36820
Heliyon 2024 Sep 15;10(17):e36820
Time-restricted feeding relieves high temperature-induced impairment on meat quality by activating the Nrf2/HO-1 pathway, modification of muscle fiber composition, and enriching the polyunsaturated fatty acids in pigs.
Li Z, Wang Y, Yuan P, Zhu Y, Hu P, Song T, Liu R, Liu HY, Cai D
Stress biology 2024 Sep 14;4(1):39
Stress biology 2024 Sep 14;4(1):39
Occlusal disharmony promotes anxiety-like behaviours by suppressing Sirt1.
Wu L, Zhang S, Zhang M, Ou Y, Chen J
Clinical oral investigations 2024 Sep 14;28(10):526
Clinical oral investigations 2024 Sep 14;28(10):526
Ocotillol Derivatives Mitigate Retinal Ischemia-Reperfusion Injury by Regulating the Keap1/Nrf2/ARE Signaling Pathway.
Zhang X, Zhang W, Zhao L, Ma G, Huang Y, Geng Z, Jiang Q, Wen X, Lin Y, Meng Q, Zhang Z, Bi Y
Journal of medicinal chemistry 2024 Sep 12;67(17):15268-15290
Journal of medicinal chemistry 2024 Sep 12;67(17):15268-15290
Phosphatase LHPP confers prostate cancer ferroptosis activation by modulating the AKT-SKP2-ACSL4 pathway.
Xie G, Li N, Li K, Xu Y, Zhang Y, Cao S, Huang B, Liu R, Zhou P, Ding Y, Ding Y, Yang J, Jia Z, Huang Z
Cell death & disease 2024 Sep 11;15(9):665
Cell death & disease 2024 Sep 11;15(9):665
Dietary nitrate maintains homeostasis of oxidative stress and gut microbiota to promote flap survival in type 2 diabetes mellitus rats.
Niu Q, Li D, Guo W, Feng Z, Han Z, Yang Y
BMC endocrine disorders 2024 Sep 10;24(1):184
BMC endocrine disorders 2024 Sep 10;24(1):184
Borna disease virus 1 induces ferroptosis, contributing to lethal encephalitis.
Tan Q, Yang H, He Y, Shen X, Sun L, Du X, Lin G, Zhou N, Wang N, Zhou Q, Liu D, Xu X, Zhao L, Xie P
Journal of medical virology 2024 Oct;96(10):e29945
Journal of medical virology 2024 Oct;96(10):e29945
Apo-12'-capsorubinal exhibits anti-inflammatory effects and activates nuclear factor erythroid 2-related factor 2 in RAW264.7 macrophages.
Takatani N, Miyafusa H, Yamano Y, Beppu F, Hosokawa M
Archives of biochemistry and biophysics 2024 Oct;760:110125
Archives of biochemistry and biophysics 2024 Oct;760:110125
Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1/Nrf2/HO-1 Signaling Pathway.
Feng J, Ji K, Pan Y, Huang P, He T, Xing Y
Molecular neurobiology 2024 Oct;61(10):8454-8466
Molecular neurobiology 2024 Oct;61(10):8454-8466
Pongamol Prevents Neurotoxicity via the Activation of MAPKs/Nrf2 Signaling Pathway in H(2)O(2)-Induced Neuronal PC12 Cells and Prolongs the Lifespan of Caenorhabditis elegans.
Wu S, Miao J, Zhu S, Wu X, Shi J, Zhou J, Xing Y, Hu K, Ren J, Yang H
Molecular neurobiology 2024 Oct;61(10):8219-8233
Molecular neurobiology 2024 Oct;61(10):8219-8233
Targeting Mitochondrial Oxidative Stress to Protect Against Preterm Birth and Fetal Brain Injury via Nrf2 Induction.
Chen C, Zhu S, Fu T, Chen Y, Bai L, Chen D
Antioxidants & redox signaling 2024 Oct;41(10-12):597-615
Antioxidants & redox signaling 2024 Oct;41(10-12):597-615
Anti-oxidative stress and cognitive improvement of a semi-synthetic isoorientin-based GSK-3β inhibitor in rat pheochromocytoma cell PC12 and scopolamine-induced AD model mice via AKT/GSK-3β/Nrf2 pathway.
Zhao Y, He C, Hu S, Ni H, Tan X, Zhi Y, Yi L, Na R, Li Y, Du Q, Li QX, Dong Y
Experimental neurology 2024 Oct;380:114881
Experimental neurology 2024 Oct;380:114881
Mangiferin activates the nuclear factor erythroid 2-related factor pathway to protect SOD1-G93A induced NSC-34 motor neurons from oxidative stress and apoptosis.
Su B, He Z, Liu J, Li M, Huang X
Journal of biochemical and molecular toxicology 2024 Oct;38(10):e23849
Journal of biochemical and molecular toxicology 2024 Oct;38(10):e23849
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
Pan F, Yang W, Zhao T, Liu K, Zhao S, Zhao L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
FTO alleviated ferroptosis in septic cardiomyopathy via mediating the m6A modification of BACH1.
Zeng H, Xu J, Wu R, Wang X, Jiang Y, Wang Q, Guo J, Xiao F
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167307
Bombesin protects myocardium against ischemia/reperfusion injury via activation of the Keap1-Nrf2-HO-1 signaling pathway.
Zhang J, Du Y, Xiong Z, Cheng H, Du Y, Xiong Y, Lv J, Huang W, Qiu K, Zhang S
Peptides 2024 Oct;180:171279
Peptides 2024 Oct;180:171279
Artemether ameliorates acetaminophen-induced liver injury through Nrf2 pathway.
Yu S, Yang N, Li H, Hu X, Zhang L, Li S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117280
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117280
p-Hydroxy benzaldehyde, a phenolic compound from Nostoc commune, ameliorates DSS-induced colitis against oxidative stress via the Nrf2/HO-1/NQO-1/NF-κB/AP-1 pathway.
Liu M, Guan G, Wang Y, Lu X, Duan X, Xu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155941
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155941
Gui Qi Zhuang Jin Decoction ameliorates mitochondrial dysfunction in sarcopenia mice via AMPK/PGC-1α/Nrf2 axis revealed by a metabolomics approach.
Wang D, Qi W, Mao X, Zhang Y, Miao Z, Zhu C, Shao Y, Ge G, Zhang W, Jin H, Zhu H, Pan H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155908
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155908
Phenylpropanoid-rich maize root extract serves as a natural antidepressant.
Zhong T, Zhang Y, Yang H, Luo F, Xu Y, Fan Y, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155893
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155893
Neutrophil-Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy.
Yang Y, Du J, Gan J, Song X, Shu J, An C, Lu L, Wei H, Che J, Zhao X
Advanced healthcare materials 2024 Oct;13(26):e2401198
Advanced healthcare materials 2024 Oct;13(26):e2401198
Human umbilical cord mesenchymal stem cells-derived exosomes attenuate burn-induced acute lung injury via inhibiting ferroptosis.
Li L, Song QQ, Li SR, Jia ZG, Sun XC, Zhao YT, Deng JB, Wu JJ, Ni T, Liu JS
Acta histochemica 2024 Oct;126(5-7):152189
Acta histochemica 2024 Oct;126(5-7):152189
Targeting Bacteria-Induced Ferroptosis of Bone Marrow Mesenchymal Stem Cells to Promote the Repair of Infected Bone Defects.
Yuan K, Yang Y, Lin Y, Zhou F, Huang K, Yang S, Kong W, Li F, Kan T, Wang Y, Cheng C, Liang Y, Chang H, Huang J, Ao H, Yu Z, Li H, Liu Y, Tang T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2404453
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Oct;11(39):e2404453
Orally Administered Ginkgolide C Alleviates MPTP-Induced Neurodegeneration by Suppressing Neuroinflammation and Oxidative Stress through Microbiota-Gut-Brain Axis in Mice.
Gao X, Fu S, Wen J, Yan A, Yang S, Zhang Y, Liu D, He D
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Journal of agricultural and food chemistry 2024 Oct 9;72(40):22115-22131
Dietary ferulic acid supplementation enhances antioxidant capacity and alleviates hepatocyte pyroptosis in diquat challenged piglets.
Luo J, Wu X, Chen D, Yu B, He J
Journal of animal science and biotechnology 2024 Oct 7;15(1):134
Journal of animal science and biotechnology 2024 Oct 7;15(1):134
Sodium Hydrosulfide Protects Rats from Hypobaric-Hypoxia-Induced Acute Lung Injury.
Wang R, Ma S, Yang J, Luo K, Qian Q, Pan J, Liang K, Wang Y, Gao Y, Li M
International journal of molecular sciences 2024 Oct 5;25(19)
International journal of molecular sciences 2024 Oct 5;25(19)
Acupoint Autohemotherapy Alleviates Airway Inflammation in Asthmatic Rats via Upregulating Expression of Hemeoxygenase-1.
Liu HL, Wu T, Zeng X, Cao WY, Wu SK
Journal of acupuncture and meridian studies 2024 Oct 31;17(5):149-157
Journal of acupuncture and meridian studies 2024 Oct 31;17(5):149-157
Qifu-yin activates the Keap1/Nrf2/ARE signaling and ameliorates synaptic injury and oxidative stress in APP/PS1 mice.
Wang S, Huang J, Chen Y, Liang Y, Chen L, Ye D, Yang H, Hui Z, Wang X, Zhang Z, Zhu X
Journal of ethnopharmacology 2024 Oct 28;333:118497
Journal of ethnopharmacology 2024 Oct 28;333:118497
Essential oil from Chimonanthus nitens Oliv. Leaves ameliorate inflammation and oxidative stress in LPS-induced ALI through NF-κB and Nrf2 signaling pathways.
Gao B, Qian X, Guo Y, Dong W, Yang M, Yang H, Huang X, Liang X
Journal of ethnopharmacology 2024 Oct 28;333:118470
Journal of ethnopharmacology 2024 Oct 28;333:118470
Dioscin exerts nephroprotective effects by attenuating oxidative stress and necroptosis-induced inflammation.
Wang S, Lei Z, Chen S, Xiang A, Zou Y, Liu Y
International immunopharmacology 2024 Oct 25;140:112885
International immunopharmacology 2024 Oct 25;140:112885
Ellagic Acid Reduces Cadmium Exposure-Induced Apoptosis in HT22 Cells via Inhibiting Oxidative Stress and Mitochondrial Dysfunction and Activating Nrf2/HO-1 Pathway.
Liu Y, Chen C, Hao Z, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2024 Oct 25;13(11)
Antioxidants (Basel, Switzerland) 2024 Oct 25;13(11)
Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling.
Zhang G, Liang Z, Wang Y, Zhang Z, Hoi PM
Antioxidants (Basel, Switzerland) 2024 Oct 21;13(10)
Antioxidants (Basel, Switzerland) 2024 Oct 21;13(10)
A novel role for WZ3146 in the inhibition of cell proliferation via ERK and AKT pathway in the rare EGFR G719X mutant cells.
Li L, Liu C, Wang R, Yang X, Wei X, Chu C, Zhang G, Liu C, Cui W, Xu H, Wang K, An L, Li X
Scientific reports 2024 Oct 2;14(1):22895
Scientific reports 2024 Oct 2;14(1):22895
Role of iron homeostasis in the mutagenicity of disinfection by-products in mammalian cells.
Zhou Y, Liu Y, Wang T, Li H, He J, Xu A
Ecotoxicology and environmental safety 2024 Oct 15;285:117122
Ecotoxicology and environmental safety 2024 Oct 15;285:117122
Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study.
Zhuang LG, Zhang R, Jin GX, Pei XY, Wang Q, Ge XX
World journal of diabetes 2024 Oct 15;15(10):2111-2122
World journal of diabetes 2024 Oct 15;15(10):2111-2122
Ginsenoside Re Regulates Oxidative Stress through the PI3K/Akt/Nrf2 Signaling Pathway in Mice with Scopolamine-Induced Memory Impairments.
Li X, Zheng K, Chen H, Li W
Current issues in molecular biology 2024 Oct 13;46(10):11359-11374
Current issues in molecular biology 2024 Oct 13;46(10):11359-11374
Isoliquiritigenin alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the Nrf2 pathway.
Lan X, Wang Q, Liu Y, You Q, Wei W, Zhu C, Hai D, Cai Z, Yu J, Zhang J, Liu N
Redox biology 2024 Nov;77:103406
Redox biology 2024 Nov;77:103406
Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1.
Deng Y, Zeng L, Liu H, Zuo A, Zhou J, Yang Y, You Y, Zhou X, Peng B, Lu H, Ji S, Wang M, Lai Y, Kwan HY, Sun X, Wang Q, Zhao X
Redox biology 2024 Nov;77:103360
Redox biology 2024 Nov;77:103360
A two-pronged approach to inhibit ferroptosis of MSCs caused by the iron overload in postmenopausal osteoporosis and promote osseointegration of titanium implant.
Yang Y, Zhang X, Yang Y, Gao P, Fan W, Zheng T, Yang W, Tang Y, Cai K
Bioactive materials 2024 Nov;41:336-354
Bioactive materials 2024 Nov;41:336-354
Ferulic Acid Inhibits Arsenic-Induced Colon Injury by Improving Intestinal Barrier Function.
Wang S, Hong Y, Li Y, Zhang Z, Han J, Yang Z, Yang Y, Ma Z, Wang Q
Environmental toxicology 2024 Nov;39(11):4821-4831
Environmental toxicology 2024 Nov;39(11):4821-4831
Ferulic Acid Protects Human Lens Epithelial Cells Against UVA-Induced Oxidative Damage by Downregulating the DNA Demethylation of the Keap1 Promoter.
Ling X, Zhu L, Yan Y, Qian H, Kang Z, Ye W, Xie Z, Xue C
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70031
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70031
Mechanical Stress-Oxidative Stress Axis: Biological Basis in the Vaginal Wall and Pelvic Floor Muscles of Rats with Simulated Birth Injury.
Wang Q, Wu X, Wang S, Xie B, Sun X, Wang J
International urogynecology journal 2024 Nov;35(11):2141-2152
International urogynecology journal 2024 Nov;35(11):2141-2152
The Neuroprotective Mechanisms of PPAR-γ: Inhibition of Microglia-Mediated Neuroinflammation and Oxidative Stress in a Neonatal Mouse Model of Hypoxic-Ischemic White Matter Injury.
Fang M, Yu Q, Ou J, Lou J, Zhu J, Lin Z
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
CNS neuroscience & therapeutics 2024 Nov;30(11):e70081
Polysaccharide of Dicliptera chinensis (L.) Juss. alleviated cholestatic liver disease by modulating the FXR pathway.
Tang Z, Zhong M, Cao H, Wang Y, Guan G, Wang G, Wu J, Han F, Gao Y, Zhang K
International journal of biological macromolecules 2024 Nov;281(Pt 4):136393
International journal of biological macromolecules 2024 Nov;281(Pt 4):136393
Lycium barbarum polysaccharides (LBP) suppresses hypoxia/reoxygenation (H/R)-induced rat H9C2 cardiomyocytes pyroptosis via Nrf2/HO-1 signaling pathway.
Gao Y, Li H, Que Y, Chen W, Huang SY, Liu W, Ye X
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
International journal of biological macromolecules 2024 Nov;280(Pt 4):135924
Vitamin U alleviates AFB(1)-induced hepatotoxicity in pregnant and lactating mice by regulating the Nrf2/Hmox1 pathway.
Ling C, Liu S, Meng K, Wang Y, Zhang X, Liu J, Li X, Liu K, Deng H, Li C
Research in veterinary science 2024 Nov;180:105436
Research in veterinary science 2024 Nov;180:105436
Lutein protects senescent ciliary muscle against oxidative stress through the Keap1/Nrf2/ARE pathway.
Gao N, Gao X, Du M, Xiang Y, Zuo H, Huang R, Wan W, Hu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155982
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155982
S. glabra exerts anti-lung cancer effects by inducing ferroptosis and anticancer immunity.
Liu S, Zhang L, Ding K, Zeng B, Li B, Zhou J, Li J, Wang J, Zhang H, Sun R, Su X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155981
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155981
Human placental mesenchymal stromal cells alleviate intestinal oxidative damage in mice with graft-versus-host disease via CD73/adenosine/PI3K/Akt/GSK-3β axis.
Han K, Wang F, Ma X, Wu Y, Zhang H, Zhao Y, Wang H, Ma J, Luan X
Cellular signalling 2024 Nov;123:111372
Cellular signalling 2024 Nov;123:111372
Triptolide induces hepatotoxicity by promoting ferroptosis through Nrf2 degradation.
Guo L, Yang Y, Ma J, Xiao M, Cao R, Xi Y, Li T, Huang T, Yan M
Cell biology and toxicology 2024 Nov 6;40(1):94
Cell biology and toxicology 2024 Nov 6;40(1):94
Unveiling Smyd-2's Role in Cytoplasmic Nrf-2 Sequestration and Ferroptosis Induction in Hippocampal Neurons After Cerebral Ischemia/Reperfusion.
Liu D, Zhu Y
Cells 2024 Nov 28;13(23)
Cells 2024 Nov 28;13(23)
Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma.
Zhou Q, Dian Y, He Y, Yao L, Su H, Meng Y, Sun Y, Li D, Xiong Y, Zeng F, Liang X, Liu H, Chen X, Deng G
Journal for immunotherapy of cancer 2024 Nov 24;12(11)
Journal for immunotherapy of cancer 2024 Nov 24;12(11)
Protective Effects of L-Cysteine Against Cisplatin-Induced Oxidative Stress-Mediated Reproductive Damage.
Chiang YF, Chen YT, Huang KC, Hung WL, Chung CP, Shieh TM, Huang YJ, Ali M, Hsia SM
Antioxidants (Basel, Switzerland) 2024 Nov 23;13(12)
Antioxidants (Basel, Switzerland) 2024 Nov 23;13(12)
Microplastics Exposure Aggravates Synovitis and Pyroptosis in SLE by Activating NF-κB and NRF2/KEAP1 Signaling.
Zeng W, He S, Zhao Y, Jiang M, Wang W, Yang L, Du W, Zhuang W
Toxics 2024 Nov 22;12(12)
Toxics 2024 Nov 22;12(12)
High-throughput screening-based design of multifunctional natural polyphenol nano-vesicles to accelerate diabetic wound healing.
Zhao X, Su S, Wu C, Deng Y, Chen Y, Yu T, Li C, Zhang Y, Wang X, Zhou Y, Zhang X
Journal of nanobiotechnology 2024 Nov 21;22(1):725
Journal of nanobiotechnology 2024 Nov 21;22(1):725
Mesenchymal stromal cells deliver H(2)S-enhanced Nrf2 via extracellular vesicles to mediate mitochondrial homeostasis for repairing hypoxia-ischemia brain damage.
Gai C, Li T, Zhao Y, Cheng Y, Song Y, Luo Q, Liu D, Wang Z
Free radical biology & medicine 2024 Nov 20;225:528-545
Free radical biology & medicine 2024 Nov 20;225:528-545
Proteomic and lipidomic analysis of the mechanism underlying astragaloside IV in mitigating ferroptosis through hypoxia-inducible factor 1α/heme oxygenase 1 pathway in renal tubular epithelial cells in diabetic kidney disease.
Liu J, Ren J, Zhou L, Tan K, Du D, Xu L, Cao W, Zhang Y
Journal of ethnopharmacology 2024 Nov 15;334:118517
Journal of ethnopharmacology 2024 Nov 15;334:118517
A new strategy for Astragaloside IV in the treatment of diabetic kidney disease: Analyzing the regulation of ferroptosis and mitochondrial function of renal tubular epithelial cells.
Liu J, Yang K, Zhou L, Deng J, Rong G, Shi L, Zhang X, Ren J, Zhang Y, Cao W
International immunopharmacology 2024 Nov 15;141:112794
International immunopharmacology 2024 Nov 15;141:112794
osa-miR168a, a Plant miRNA That Survives the Process of In Vivo Food Digestion, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice by Oral Administration.
Xu Q, Li Y, Qin X, Xin Y, Wang J, Zhang Y, Xu K, Yang X, Wang X
Journal of agricultural and food chemistry 2024 Nov 13;72(45):25146-25160
Journal of agricultural and food chemistry 2024 Nov 13;72(45):25146-25160
Treatment of Parkinson's disease model with human umbilical cord mesenchymal stem cell-derived exosomes loaded with BDNF.
Wang CC, Hu XM, Long YF, Huang HR, He Y, Xu ZR, Qi ZQ
Life sciences 2024 Nov 1;356:123014
Life sciences 2024 Nov 1;356:123014
Hepatocyte-derived Fetuin-A promotes alcohol-associated liver disease in mice by inhibiting autophagy-lysosome degradation of TLR and M2 macrophage polarization.
Lu S, Jin H, Nong T, Li D, Long K, Chen Y, Li Y, Xing H, Pan T, He S, Jiang K, Zhong F
Free radical biology & medicine 2024 Nov 1;224:506-520
Free radical biology & medicine 2024 Nov 1;224:506-520
Identification of ROS and KEAP1-related genes and verified targets of α-hederin induce cell death for CRC.
Wang G, Zhu ZM, Wang K
Drug development research 2024 May;85(3):e22200
Drug development research 2024 May;85(3):e22200
Sodium butyrate alleviates experimental autoimmune prostatitis by inhibiting oxidative stress and NLRP3 inflammasome activation via the Nrf2/HO-1 pathway.
Hua X, Zhang J, Chen J, Feng R, Zhang L, Chen X, Jiang Q, Yang C, Liang C
The Prostate 2024 May;84(7):666-681
The Prostate 2024 May;84(7):666-681
BDNF mimetics recover palmitic acid-induced injury in cardiomyocytes by ameliorating Akt-dependent mitochondrial impairments.
Zhang MR, Zuo BY, Song YC, Guo DD, Li QL, Lyu JX, Zhu H, Zhao J, Hang PZ
Toxicology and applied pharmacology 2024 May;486:116951
Toxicology and applied pharmacology 2024 May;486:116951
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Zhao L, Zhang Z, Li P, Gao Y, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.
Sheng W, Li B, Sun T, Zhu C, Li Y, Xu W
Experimental and therapeutic medicine 2024 May;27(5):232
Experimental and therapeutic medicine 2024 May;27(5):232
Poly (vinyl alcohol)/sodium alginate/carboxymethyl chitosan multifunctional hydrogel loading HKUST-1 nanoenzymes for diabetic wound healing.
Chai G, Wang N, Xu M, Ma L, Liu X, Ding Q, Zhang S, Li A, Xia G, Zhao Y, Liu W, Liang D, Ding C
International journal of biological macromolecules 2024 May;268(Pt 2):131670
International journal of biological macromolecules 2024 May;268(Pt 2):131670
Mastoparan M promotes functional recovery in stroke mice by activating autophagy and inhibiting ferroptosis.
Wang Q, Liu C, Chen M, Zhao J, Wang D, Gao P, Zhang C, Zhao H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116560
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116560
Isoliquiritigenin reduces experimental autoimmune prostatitis by facilitating Nrf2 activation and suppressing the NLRP3 inflammasome pathway.
Feng R, Meng T, Zhao X, Yu W, Li H, Wang Z, Chen J, Yang C
Molecular immunology 2024 May;169:37-49
Molecular immunology 2024 May;169:37-49
Poly (Betulinic Acid) Nanoparticles Loaded with bFGF Improve Functional Recovery After Spinal Cord Injury.
Chen X, Wang B, Zhou Y, Wu X, Du A, Al Mamun A, Xu Y, Wang S, Jiang C, Xie L, Zhou K, Hu S, Xiao J
Advanced healthcare materials 2024 May;13(12):e2303462
Advanced healthcare materials 2024 May;13(12):e2303462
Essential oil from Citrus depressa peel exhibits antimicrobial, antioxidant and cancer chemopreventive effects.
Weng YX, Wang HC, Chu YL, Wu YZ, Liao JA, Su ZY
Journal of the science of food and agriculture 2024 May;104(7):3982-3991
Journal of the science of food and agriculture 2024 May;104(7):3982-3991
Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens.
Fan Y, Zhou W, Li G, Liu X, Zhong P, Liu K, Liu Y, Wang D
Poultry science 2024 May;103(5):103541
Poultry science 2024 May;103(5):103541
Metaplastic regeneration in the mouse stomach requires a reactive oxygen species pathway.
Miao ZF, Sun JX, Huang XZ, Bai S, Pang MJ, Li JY, Chen HY, Tong QY, Ye SY, Wang XY, Hu XH, Li JY, Zou JW, Xu W, Yang JH, Lu X, Mills JC, Wang ZN
Developmental cell 2024 May 6;59(9):1175-1191.e7
Developmental cell 2024 May 6;59(9):1175-1191.e7
Blocking of FGFR4 signaling by F30 inhibits hepatocellular carcinoma cell proliferation through HMOX1-dependent ferroptosis pathway.
Huang F, Shi X, Hu M, Yan H, Li X, Ding Y, Zheng X, Cai X, Dai S, Xia Q, Cai Y
European journal of pharmacology 2024 May 5;970:176493
European journal of pharmacology 2024 May 5;970:176493
Dihydroartemisinin alleviates doxorubicin-induced cardiotoxicity and ferroptosis by activating Nrf2 and regulating autophagy.
Lin ZH, Xiang HQ, Yu YW, Xue YJ, Wu C, Lin C, Ji KT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23677
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23677
Molecular, biological characterization and drug sensitivity of chidamide-resistant MCF7 cells.
Dai L, Zhang C, Gao W, Pan J, Huang S, Zhang Y, Cheng Y, Wang Y, Tao J, Wang H, Feng Z, Su C, Zhang Y
Translational cancer research 2024 May 31;13(5):2372-2386
Translational cancer research 2024 May 31;13(5):2372-2386
Indole-3-carboxaldehyde alleviates acetaminophen-induced liver injury via inhibition of oxidative stress and apoptosis.
Liu X, Liu R, Wang Y
Biochemical and biophysical research communications 2024 May 28;710:149880
Biochemical and biophysical research communications 2024 May 28;710:149880
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
Li Y, Xiao Y, Shang Y, Xu C, Han C, Hu D, Han J, Wang H
Cell biology and toxicology 2024 May 25;40(1):39
Cell biology and toxicology 2024 May 25;40(1):39
BDTX-189, a novel tyrosine kinase inhibitor, inhibits cell activity via ERK and AKT pathways in the EGFR C797S triple mutant cells.
Wang R, Cui W, Li L, Wei X, Chu C, Zhang G, Liu C, Xu H, Liu C, Wang K, Li Y, An L
Chemico-biological interactions 2024 May 25;395:111033
Chemico-biological interactions 2024 May 25;395:111033
Paeoniflorin attenuates particulate matter-induced acute lung injury by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis through activation of the Nrf2 signaling pathway.
Zhou W, Zuo H, Qian Y, Miao W, Chen C
Chemico-biological interactions 2024 May 25;395:111032
Chemico-biological interactions 2024 May 25;395:111032
Chondrocyte-targeted exosome-mediated delivery of Nrf2 alleviates cartilaginous endplate degeneration by modulating mitochondrial fission.
Lin Z, Xu G, Lu X, Liu S, Zou F, Ma X, Jiang J, Wang H, Song J
Journal of nanobiotechnology 2024 May 24;22(1):281
Journal of nanobiotechnology 2024 May 24;22(1):281
Activation of Nrf2/HO-1 signaling pathway exacerbates cholestatic liver injury.
Wang Y, Fu X, Zeng L, Hu Y, Gao R, Xian S, Liao S, Huang J, Yang Y, Liu J, Jin H, Klaunig J, Lu Y, Zhou S
Communications biology 2024 May 23;7(1):621
Communications biology 2024 May 23;7(1):621
Spinosin ameliorates osteoarthritis through enhancing the Nrf2/HO-1 signaling pathway.
Lu P, Li S, Zhang C, Jiang X, Xiang J, Xu H, Dong J, Wang K, Shi Y
European journal of histochemistry : EJH 2024 May 22;68(2)
European journal of histochemistry : EJH 2024 May 22;68(2)
Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.
Jiang XX, Zhang R, Wang HS
Aging 2024 May 21;16(10):8630-8644
Aging 2024 May 21;16(10):8630-8644
Acetaminophen overdose-induced acute liver injury can be alleviated by static magnetic field.
Chen HX, Wang XY, Yu B, Feng CL, Cheng GF, Zhang L, Wang JJ, Wang Y, Guo RW, Ji XM, Xie WJ, Chen WL, Song C, Zhang X
Zoological research 2024 May 18;45(3):478-491
Zoological research 2024 May 18;45(3):478-491
Naringin attenuates Actinobacillus pleuropneumoniae-induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway.
Huang QL, Huang LN, Zhao GY, Liu C, Pan XY, Li ZR, Jing XH, Qiu ZY, Xin RH
BMC veterinary research 2024 May 17;20(1):204
BMC veterinary research 2024 May 17;20(1):204
Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways.
Wang C, Xiong ZM, Cong YQ, Li ZY, Xie Y, Wang YX, Zhou HM, Yang YF, Liu JJ, Wu HZ
Scientific reports 2024 May 16;14(1):11240
Scientific reports 2024 May 16;14(1):11240
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway.
Huang WT, Chen XJ, Lin YK, Shi JF, Li H, Wu HD, Jiang RL, Chen S, Wang X, Tan XX, Chen KY, Wang P
European journal of pharmacology 2024 May 15;971:176521
European journal of pharmacology 2024 May 15;971:176521
Effects of Pemafibrate on Reducing Oxidative Stress and Augmenting Angiogenesis in Ischemic Limb Tissue.
Anegawa T, Sasaki KI, Ishizaki Y, Negoto S, Oryoji A, Nakamura E, Otsuka H, Hiromatsu S, Fukumoto Y, Tayama E
The Kurume medical journal 2024 May 14;69(3.4):167-174
The Kurume medical journal 2024 May 14;69(3.4):167-174
Sinensetin protects against periodontitis through binding to Bach1 enhancing its ubiquitination degradation and improving oxidative stress.
Yuan Z, Li J, Xiao F, Wu Y, Zhang Z, Shi J, Qian J, Wu X, Yan F
International journal of oral science 2024 May 11;16(1):38
International journal of oral science 2024 May 11;16(1):38
Edaravone dexborneol protects against cerebral ischemia/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2/HO-1/GPX4 signaling.
Xiao P, Huang H, Zhao H, Liu R, Sun Z, Liu Y, Chen N, Zhang Z
Free radical biology & medicine 2024 May 1;217:116-125
Free radical biology & medicine 2024 May 1;217:116-125
Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho-1/Gpx4 pathway to prevent α-synuclein-induced ferroptosis in Parkinson's disease.
Lv QK, Tao KX, Yao XY, Pang MZ, Cao BE, Liu CF, Wang F
Journal of pineal research 2024 Mar;76(2):e12948
Journal of pineal research 2024 Mar;76(2):e12948
Involvement of the Keap1-Nrf2-ARE pathway in the antioxidant activity of sinomenine.
Guan T, Li N, Xu X, Xiong D, Wang B, Xiao L, Yang W, Chu G, Yusuf A, Zhang J, Yue W
Archives of biochemistry and biophysics 2024 Mar;753:109928
Archives of biochemistry and biophysics 2024 Mar;753:109928
Glycyrrhizin regulates antioxidation through Nrf2 signaling pathway in rat temporomandibular joint osteoarthritis.
Hu Z, Zhao J, Liu X, Li Y, Jiang H, Fang W, Long X
Journal of oral rehabilitation 2024 Mar;51(3):611-622
Journal of oral rehabilitation 2024 Mar;51(3):611-622
Quercetin alleviates the toxicity of difenoconazole to the respiratory system of carp by reducing ROS accumulation and maintaining mitochondrial dynamic balance.
Ji X, Guo J, Ma Y, Zhang S, Yang Z, Li Y, Ping K, Xin Y, Dong Z
Toxicology and applied pharmacology 2024 Mar;484:116860
Toxicology and applied pharmacology 2024 Mar;484:116860
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Yuan Q, Fang Y, Guo J, Zhang Z, Liao J, Kuang J
Toxicology and applied pharmacology 2024 Mar;484:116845
Toxicology and applied pharmacology 2024 Mar;484:116845
Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation.
Mao H, Feng Y, Feng J, Yusufu Y, Sun M, Yang L, Jiang Q
Journal of orthopaedic translation 2024 Mar;45:236-246
Journal of orthopaedic translation 2024 Mar;45:236-246
Dapagliflozin Alleviates Diabetic Kidney Disease via Hypoxia Inducible Factor 1α/Heme Oxygenase 1-Mediated Ferroptosis.
Wang YH, Chang DY, Zhao MH, Chen M
Antioxidants & redox signaling 2024 Mar;40(7-9):492-509
Antioxidants & redox signaling 2024 Mar;40(7-9):492-509
MFSD7c functions as a transporter of choline at the blood-brain barrier.
Nguyen XTA, Le TNU, Nguyen TQ, Thi Thuy Ha H, Artati A, Leong NCP, Nguyen DT, Lim PY, Susanto AV, Huang Q, Fam L, Leong LN, Bonne I, Lee A, Granadillo JL, Gooch C, Yu D, Huang H, Soong TW, Chang MW, Wenk MR, Adamski J, Cazenave-Gassiot A, Nguyen LN
Cell research 2024 Mar;34(3):245-257
Cell research 2024 Mar;34(3):245-257
Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.
Jiang Z, Yang H, Ni W, Gao X, Pei X, Jiang H, Su J, Weng R, Fei Y, Gao Y, Gu Y
CNS neuroscience & therapeutics 2024 Mar;30(3):e14646
CNS neuroscience & therapeutics 2024 Mar;30(3):e14646
Electroacupuncture Attenuates Ventilator-Induced Lung Injury by Modulating the Nrf2/HO-1 Pathway.
Luo J, Yan R, Ding L, Ning J, Chen M, Guo Y, Liu J, Chen Z, Zhou R
The Journal of surgical research 2024 Mar;295:811-819
The Journal of surgical research 2024 Mar;295:811-819
Rhizoma Paridis saponins attenuate Gram-negative bacteria-induced inflammatory acne by binding to KEAP1 and modulating Nrf2 and MAPK pathways.
Yang Y, Wang C, Wang J, Yang L, Lv Z, An Q, Wang Y, Shao X, Wang F, Huo T, Liu J, Luo H, Quan Q
Journal of cellular and molecular medicine 2024 Mar;28(6):e18146
Journal of cellular and molecular medicine 2024 Mar;28(6):e18146
VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production.
Miao J, Tu Y, Jiang J, Ren R, Wu Q, Liang H, Wang T, Lin B, Wu J, Pan Y, Wang X, Jin H
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
International journal of biological macromolecules 2024 Mar;260(Pt 2):129357
Bioactive monoterpenoids and acetophenones from the aerial parts of Eupatorium fortunei.
Miao L, Wang ST, Wei QH, Ma RF, Zhang H
Phytochemistry 2024 Mar;219:113984
Phytochemistry 2024 Mar;219:113984
Nrf-2/ROS/NF-κB pathway is modulated by cynarin in human mesenchymal stem cells in vitro from ankylosing spondylitis.
Song C, Wang K, Qian B, Lu J, Qiao M, Qiu Y, Wang B, Yu Y
Clinical and translational science 2024 Mar;17(3):e13748
Clinical and translational science 2024 Mar;17(3):e13748
Retinoic acid alleviates rotavirus-induced intestinal damage by regulating redox homeostasis and autophagic flux in piglets.
Lai X, Wu A, Yu B, Yan H, Luo J, Zheng P, Yu J, Chen D
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Mar;16:409-421
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Mar;16:409-421
Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy.
Linghu KG, Zhang T, Zhang GT, Lv P, Zhang WJ, Zhao GD, Xiong SH, Ma QS, Zhao MM, Chen M, Hu YJ, Zhang CS, Yu H
Journal of pharmaceutical analysis 2024 Mar;14(3):401-415
Journal of pharmaceutical analysis 2024 Mar;14(3):401-415
Poliumoside protects against type 2 diabetes-related osteoporosis by suppressing ferroptosis via activation of the Nrf2/GPX4 pathway.
Xu CY, Xu C, Xu YN, Du SQ, Dai ZH, Jin SQ, Zheng G, Xie CL, Fang WL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155342
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Mar;125:155342
X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity.
Hong Y, Zhou X, Li Q, Chen J, Wei Y, Long C, Shen L, Zheng X, Li D, Wang X, Yu C, Wu S, Wei G
Genes & diseases 2024 Mar;11(2):935-951
Genes & diseases 2024 Mar;11(2):935-951
VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2/HO-1 Signaling Pathway in Diabetic Nephropathy.
Wang H, Yu X, Liu D, Qiao Y, Huo J, Pan S, Zhou L, Wang R, Feng Q, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2305563
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2305563
Role of Nrf2/HO-1 pathway on inhibiting activation of ChTLR15/ChNLRP3 inflammatory pathway stimulated by E. tenella sporozoites.
Bai B, Liu Q, Kong R, Jia Z, Chen H, Zhi W, Wang B, Ma C, Ma D
Poultry science 2024 Mar;103(3):103445
Poultry science 2024 Mar;103(3):103445
Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice.
Wang B, Zhu S, Guo M, Ma RD, Tang YL, Nie YX, Gu HF
Molecular medicine (Cambridge, Mass.) 2024 Mar 7;30(1):35
Molecular medicine (Cambridge, Mass.) 2024 Mar 7;30(1):35
Inhibition of SAT1 alleviates chondrocyte inflammation and ferroptosis by repressing ALOX15 expression and activating the Nrf2 pathway.
Xu J, Ruan Z, Guo Z, Hou L, Wang G, Zheng Z, Zhang X, Liu H, Sun K, Guo F
Bone & joint research 2024 Mar 7;13(3):110-123
Bone & joint research 2024 Mar 7;13(3):110-123
Fisetin Alleviates Inflammation and Oxidative Stress in Deep Vein Thrombosis via MAPK and NRF2 Signaling Pathway.
Liu H, Lu Q
International journal of molecular sciences 2024 Mar 27;25(7)
International journal of molecular sciences 2024 Mar 27;25(7)
Glutathione Induces Keap1 S-Glutathionylation and Mitigates Oscillating Glucose-Induced β-Cell Dysfunction by Activating Nrf2.
Chen X, Zhou Q, Chen H, Bai J, An R, Zhang K, Zhang X, An H, Zhang J, Wang Y, Li M
Antioxidants (Basel, Switzerland) 2024 Mar 27;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 27;13(4)
Bi(2)S(3)/Ti(3)C(2)-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors.
Jiang H, Sun J, Liu F, Zhao Y, Chen X, Dai C, Wen Z
Journal of nanobiotechnology 2024 Mar 20;22(1):123
Journal of nanobiotechnology 2024 Mar 20;22(1):123
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Xin X, Liu J, Liu X, Xin Y, Hou Y, Xiang X, Deng Y, Yang B, Yu W
ACS nano 2024 Mar 19;18(11):8307-8324
ACS nano 2024 Mar 19;18(11):8307-8324
Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation.
Wang W, Zhou C, Ma Z, Zeng L, Wang H, Cheng X, Zhang C, Xue Y, Yuan Y, Li J, Hu L, Huang J, Luo T, Zheng L
Ecotoxicology and environmental safety 2024 Mar 15;273:116121
Ecotoxicology and environmental safety 2024 Mar 15;273:116121
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment.
Yi T, Liu Z, Jia H, Liu Q, Peng J
Iranian journal of immunology : IJI 2024 Mar 12;21(1):37-52
Iranian journal of immunology : IJI 2024 Mar 12;21(1):37-52
From inflammation to pyroptosis: Understanding the consequences of cadmium exposure in chicken liver cells.
Li L, Xu H, Wang Y, Zhang Y, Ye R, Li W, Yang J, Wu J, Li J, Jin E, Cao M, Li X, Li S, Liu C
Ecotoxicology and environmental safety 2024 Mar 1;272:116004
Ecotoxicology and environmental safety 2024 Mar 1;272:116004
Acupuncture alleviates CUMS-induced depression-like behaviors of rats by regulating oxidative stress, neuroinflammation and ferroptosis.
Shen J, Hao C, Yuan S, Chen W, Tong T, Chen Y, Shahzad Aslam M, Yan S, Li J, Zeng J, Liu S, Chen Y, Jiang Y, Li P, Meng X
Brain research 2024 Mar 1;1826:148715
Brain research 2024 Mar 1;1826:148715
TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo.
Zhou C, Li D, He J, Luo T, Liu Y, Xue Y, Huang J, Zheng L, Li J
Antioxidants (Basel, Switzerland) 2024 Mar 1;13(3)
Antioxidants (Basel, Switzerland) 2024 Mar 1;13(3)
Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.
Liu X, Wang N, Gu S, He Z
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289
Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis.
Ye Y, Xu L, Zhang L, Zhao P, Cai W, Fu G, Wang T, Tao Z, Shi W, Gu W, Hu J, Yuan G, Wei Y, Xu K, Bao Z, Chao H, Liu N, Zhao L, Tu Y, Ji J
Redox biology 2024 Jun;72:103137
Redox biology 2024 Jun;72:103137
A Disintegrin and Metalloproteinase-8 Protects Against Erastin-Induced Neuronal Ferroptosis via Activating Nrf2/HO-1/FTH1 Signaling Pathway.
Qian Z, Zhang Q, Li P, Li Y, Zhang Y, Li R, Zhao T, Xia M, Chen Y, Hong X
Molecular neurobiology 2024 Jun;61(6):3490-3502
Molecular neurobiology 2024 Jun;61(6):3490-3502
Reactive metabolite of trovafloxacin activates inflammasomes: Implications for trovafloxacin-induced liver injury.
Tanaka S, Noda T, Urashima K, Ijiri Y, Kohda Y, Kato R
Journal of applied toxicology : JAT 2024 Jun;44(6):846-852
Journal of applied toxicology : JAT 2024 Jun;44(6):846-852
Arecoline induces neurotoxicity in HT22 cells via the promotion of endoplasmic reticulum stress and downregulation of the Nrf2/HO-1 pathway.
Yan H, Ding J, Li X, Li S, Zhang D
Environmental toxicology 2024 Jun;39(6):3410-3424
Environmental toxicology 2024 Jun;39(6):3410-3424
Inhibitor of apoptosis stimulating protein of p53 protects against MPP(+)-induced neurotoxicity of dopaminergic neurons.
Chen L, Duan F, Ge F, Tian L, Li Y, Li Y, Zhu Q, Zhou Q, Lin H
Metabolic brain disease 2024 Jun;39(5):871-884
Metabolic brain disease 2024 Jun;39(5):871-884
Celastrol enhances the viability of random-pattern skin flaps by regulating autophagy through the AMPK-mTOR-TFEB axis.
Gu M, Li C, Deng Q, Chen X, Lei R
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Phytotherapy research : PTR 2024 Jun;38(6):3020-3036
Bicyclol Alleviates Streptozotocin-induced Diabetic Cardiomyopathy By Inhibiting Chronic Inflammation And Oxidative Stress.
Zhang L, Hu C, Jin B, Bai B, Liao J, Jin L, Wang M, Zhu W, Wu X, Zheng L, Xu X, Jiang Y, Wang Y, He Y
Cardiovascular drugs and therapy 2024 Jun;38(3):555-568
Cardiovascular drugs and therapy 2024 Jun;38(3):555-568
The TF/Nrf2/GSTP1 pathway is involved in stress-induced hepatocellular injury through ferroptosis.
Tian X, Li Y, Lei L, Feng X, Xin H, Chen H, Zhang G, Zuo M, Shi W, Cong B
Journal of cellular and molecular medicine 2024 Jun;28(12):e18494
Journal of cellular and molecular medicine 2024 Jun;28(12):e18494
Cu(2)WS(4)-PEG Nanozyme as Multifunctional Sensitizers for Enhancing Immuno-Radiotherapy by Inducing Ferroptosis.
Fu S, Li Y, Shen L, Chen Y, Lu J, Ran Y, Zhao Y, Tang H, Tan L, Lin Q, Hao Y
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2309537
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2309537
New sesquiterpenoids with neuroprotective effects in vitro and in vivo from the Picrasma chinensis.
Fan XZ, Song JQ, Shi XY, Zhou JF, Yuan RJ, Liu T, Kong XQ, Huang YS, Zhang LJ, Liao HB
Fitoterapia 2024 Jun;175:105908
Fitoterapia 2024 Jun;175:105908
Dihydromyricetin regulates KEAP1-Nrf2 pathways to enhance the survival of ischemic flap.
Tao X, Pan X, Zhao G, Xue M, Rui Y
Food science & nutrition 2024 Jun;12(6):3893-3909
Food science & nutrition 2024 Jun;12(6):3893-3909
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
Hu Y, Hao R, Li D, Lu Y, Yu G
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases.
Liao W, Li Y, Liu J, Mou Y, Zhao M, Liu J, Zhang T, Sun Q, Tang J, Wang Z
Cell communication and signaling : CCS 2024 Jun 7;22(1):315
Cell communication and signaling : CCS 2024 Jun 7;22(1):315
Discovery of 4-benzylpiperazinequinoline BChE inhibitor that suppresses neuroinflammation for the treatment of Alzheimer's disease.
Chen Y, Zhang W, Li Q, Xie H, Xing S, Lu X, Lyu W, Xiong B, Wang Y, Qu W, Liu W, Chi H, Zhang X, Feng F, Sun H
European journal of medicinal chemistry 2024 Jun 5;272:116463
European journal of medicinal chemistry 2024 Jun 5;272:116463
Mechanistic studies on the alleviation of ANIT-induced cholestatic liver injury by Polygala fallax Hemsl. polysaccharides.
Guan G, Cao H, Tang Z, Zhang K, Zhong M, Lv R, Wan W, Guo F, Wang Y, Gao Y
Journal of ethnopharmacology 2024 Jun 28;328:118108
Journal of ethnopharmacology 2024 Jun 28;328:118108
Mesenchymal stem cells-extracellular vesicles alleviate pulmonary fibrosis by regulating immunomodulators.
Gao Y, Liu MF, Li Y, Liu X, Cao YJ, Long QF, Yu J, Li JY
World journal of stem cells 2024 Jun 26;16(6):670-689
World journal of stem cells 2024 Jun 26;16(6):670-689
Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis.
Wang G, Xie W, Deng L, Huang X, Sun M, Liu W, Tang S
Chinese medicine 2024 Jun 19;19(1):88
Chinese medicine 2024 Jun 19;19(1):88
Fucoxanthin alleviates lipopolysaccharide-induced intestinal barrier injury in mice.
Du L, Chen C, Yang YH, Zheng Y, Li H, Wu ZJ, Wu H, Miyashita K, Su GH
Food & function 2024 Jun 17;15(12):6359-6373
Food & function 2024 Jun 17;15(12):6359-6373
The male reproductive toxicity after 5-Fluorouracil exposure: DNA damage, oxidative stress, and mitochondrial dysfunction in vitro and in vivo.
Yuan W, Ji G, Shi X, Sun Z, Liu C, Yu Y, Li W, Wang X, Hu H
Ecotoxicology and environmental safety 2024 Jun 15;278:116465
Ecotoxicology and environmental safety 2024 Jun 15;278:116465
Exposure to polystyrene nanoplastics induces hepatotoxicity involving NRF2-NLRP3 signaling pathway in mice.
Wen Y, Deng S, Wang B, Zhang F, Luo T, Kuang H, Kuang X, Yuan Y, Huang J, Zhang D
Ecotoxicology and environmental safety 2024 Jun 15;278:116439
Ecotoxicology and environmental safety 2024 Jun 15;278:116439
Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload.
Wang C, Zhao H, Liu Y, Qu M, Lv S, He G, Liang H, Chen K, Yang L, He Y, Ou C
Ecotoxicology and environmental safety 2024 Jun 15;278:116404
Ecotoxicology and environmental safety 2024 Jun 15;278:116404
X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway.
Du MW, Zhu XL, Zhang DX, Chen XZ, Yang LH, Xiao JZ, Fang WJ, Xue XC, Pan WH, Liao WQ, Yang T
World journal of diabetes 2024 Jun 15;15(6):1299-1316
World journal of diabetes 2024 Jun 15;15(6):1299-1316
FGF10 protects against particulate matter-induced lung injury by inhibiting ferroptosis via Nrf2-dependent signaling.
Qian Y, Shi Q, Zhou W, He B, Xu H, Liu B, Miao W, Bellusci S, Chen C, Dong N
International immunopharmacology 2024 Jun 15;134:112165
International immunopharmacology 2024 Jun 15;134:112165
Cytoprotective Role of Autophagy in CDIP1 Expression-Induced Apoptosis in MCF-7 Breast Cancer Cells.
Inukai R, Mori K, Maki M, Takahara T, Shibata H
International journal of molecular sciences 2024 Jun 13;25(12)
International journal of molecular sciences 2024 Jun 13;25(12)
Octanoic acid mitigates busulfan-induced blood-testis barrier damage by alleviating oxidative stress and autophagy.
Cao C, Zhang H, He Z, Zhang K, Qian Z, Shen J, Zheng L, Xue M, Sun S, Li C, Zhao W, Jing J, Ma R, Ge X, Yao B
Lipids in health and disease 2024 Jun 11;23(1):180
Lipids in health and disease 2024 Jun 11;23(1):180
Hsa_circ_0096157 silencing suppresses autophagy and reduces cisplatin resistance in non-small cell lung cancer by weakening the Nrf2/ARE signaling pathway.
Lu H, Kong J, Cai S, Huang H, Luo J, Liu L
Molecular biology reports 2024 Jun 1;51(1):703
Molecular biology reports 2024 Jun 1;51(1):703
HMOX1 regulates ferroptosis via mic14 and its impact on chemotherapy resistance in small-cell lung cancer.
Sun Y, Zhang J
Anti-cancer drugs 2024 Jun 1;35(5):397-411
Anti-cancer drugs 2024 Jun 1;35(5):397-411
HO-1 upregulation promotes mitophagy-dependent ferroptosis in PM2.5-exposed hippocampal neurons.
Li X, Ran Q, He X, Peng D, Xiong A, Jiang M, Zhang L, Wang J, Bai L, Liu S, Li S, Sun B, Li G
Ecotoxicology and environmental safety 2024 Jun 1;277:116314
Ecotoxicology and environmental safety 2024 Jun 1;277:116314
Conditional Knockout of IL-1R1 in Endothelial Cells Attenuates Seizures and Neurodegeneration via Inhibiting Neuroinflammation Mediated by Nrf2/HO-1/NLRP3 Signaling in Status Epilepticus Model.
Wu L, Zhu Y, Qin Y, Yuan H, Zhang L, Lu T, Chen Q, Hu A
Molecular neurobiology 2024 Jul;61(7):4289-4303
Molecular neurobiology 2024 Jul;61(7):4289-4303
Heme oxygenase activates calcium release from the endoplasmic reticulum of bovine mammary epithelial cells to promote TFEB entry into the nucleus to reduce the intracellular load of Mycoplasma bovis.
Xu M, Zhu Z, Meng S, Li H, Wang A, Barkema HW, Cobo ER, Kastelic JP, Khan MA, Gao J, Han B
Microbiological research 2024 Jul;284:127727
Microbiological research 2024 Jul;284:127727
PEDF and 34-mer peptide inhibit cardiac microvascular endothelial cell ferroptosis via Nrf2/HO-1 signalling in myocardial ischemia-reperfusion injury.
Lu P, Qi Y, Li X, Zhang C, Chen Z, Shen Z, Liang J, Zhang H, Yuan Y
Journal of cellular and molecular medicine 2024 Jul;28(14):e18558
Journal of cellular and molecular medicine 2024 Jul;28(14):e18558
Mechanism and functional verification of genes by virulence factors of P. gingivalis in ferroptosis.
Li X, Chen T, Fu Y, Yang B, Lin X, Hou J, Yang X
Archives of oral biology 2024 Jul;163:105965
Archives of oral biology 2024 Jul;163:105965
Emodin alleviates intestinal ischemia-reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation.
Liu Y, Ji T, Jiang H, Chen M, Liu W, Zhang Z, He X
Journal of inflammation (London, England) 2024 Jul 9;21(1):25
Journal of inflammation (London, England) 2024 Jul 9;21(1):25
Acetyl-11-keto-β-boswellic acid restrains the progression of synovitis in osteoarthritis via the Nrf2/HO-1 pathway.
Zhou J, Li X, Han Z, Qian Y, Bai L, Han Q, Gao M, Xue Y, Geng D, Yang X, Hao Y
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
Acta biochimica et biophysica Sinica 2024 Jul 8;56(11):1644-1658
Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps.
Lai Y, Yang N, Shi D, Ma X, Huang Y, Lu J, Zhang X, Zhou H, Gao W, Mao C, Wang L
European journal of pharmacology 2024 Jul 5;974:176621
European journal of pharmacology 2024 Jul 5;974:176621
SUMOylation modification of FTO facilitates oxidative damage response of arsenic by IGF2BP3 in an m6A-dependent manner.
Zhang H, Chen Q, Han H, Guo C, Jiang X, Xia Y, Zhang Y, Zhou L, Zhang J, Tian X, Mao L, Qiu J, Zou Z, Chen C
Journal of hazardous materials 2024 Jul 5;472:134440
Journal of hazardous materials 2024 Jul 5;472:134440
Polystyrene Microplastics Causes Diarrhea and Impairs Intestinal Angiogenesis through the ROS/METTL3 Pathway.
Zou D, Yang Y, Ji F, Lv R, Wu H, Hou G, Xu T, Zhou H, Hu C
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16638-16650
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16638-16650
Baicalin promotes the sensitivity of NSCLC to cisplatin by regulating ferritinophagy and macrophage immunity through the KEAP1-NRF2/HO-1 pathway.
Chen Y, Bao S, Wang Z, Fang Z, Tang H
European journal of medical research 2024 Jul 26;29(1):387
European journal of medical research 2024 Jul 26;29(1):387
Quercetin inhibits neuronal Ferroptosis and promotes immune response by targeting lipid metabolism-related gene PTGS2 to alleviate breast cancer-related depression.
Zhu Q, Han Y, He Y, Meng P, Fu Y, Yang H, He G, Long M, Shi Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155560
Protective effects of patchouli alcohol against DSS-induced ulcerative colitis.
Han H, Gao M, Wang F, Luo Z, Jiang X, Qiu Y, Su J, Duan X, Luo S, Tang S, Khan A, Zou Z, Chen C, Yin Q, Qiu J, Zhang H
Scientific reports 2024 Jul 20;14(1):16745
Scientific reports 2024 Jul 20;14(1):16745
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
Li Y, Deng X, Hu Q, Chen Y, Zhang W, Qin X, Wei F, Lu X, Ma X, Zeng J, Efferth T
Journal of ethnopharmacology 2024 Jul 15;329:118107
Journal of ethnopharmacology 2024 Jul 15;329:118107
LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia.
Weindel CG, Ellzey LM, Coleman AK, Patrick KL, Watson RO
bioRxiv : the preprint server for biology 2024 Jul 13;
bioRxiv : the preprint server for biology 2024 Jul 13;
Bacillus cereus CwpFM induces colonic tissue damage and inflammatory responses through oxidative stress and the NLRP3/NF-κB pathway.
Shan Q, Wang X, Yang H, Zhu Y, Wang J, Yang G
The Science of the total environment 2024 Jul 10;933:173079
The Science of the total environment 2024 Jul 10;933:173079
Protective effects of L-theanine and dihydromyricetin on reproductive function in male mice under heat stress.
Yang D, Xu K, Wang W, Chen P, Liu C, Liu S, Xu W, Xiao W
Food & function 2024 Jul 1;15(13):7093-7107
Food & function 2024 Jul 1;15(13):7093-7107
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Chen L, Qi E, Liu X, Cui L, Fan X, Wei T, Hu Y
Toxicology and applied pharmacology 2024 Jan;482:116766
Toxicology and applied pharmacology 2024 Jan;482:116766
Aristolochic acid I aggravates oxidative stress-mediated apoptosis by inhibiting APE1/Nrf2/HO-1 signaling.
Zhang Q, Tian L, Hu Y, Jiang W, Wang X, Chen L, Cheng S, Ying J, Jiang B, Zhang L
Toxicology mechanisms and methods 2024 Jan;34(1):20-31
Toxicology mechanisms and methods 2024 Jan;34(1):20-31
KAN0438757, a novel PFKFB3 inhibitor, prevent the progression of severe acute pancreatitis via the Nrf2/HO-1 pathway in infiltrated macrophage.
Ergashev A, Shi F, Liu Z, Pan Z, Xie H, Kong L, Wu L, Sun H, Jin Y, Kong H, Geng D, Ibrohimov A, Obeng E, Wang Y, Ma F, Chen G, Zhang T
Free radical biology & medicine 2024 Jan;210:130-145
Free radical biology & medicine 2024 Jan;210:130-145
Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats.
Tong T, Hao C, Shen J, Liu S, Yan S, Aslam MS, Chen Y, Chen W, Li J, Li Y, Zeng J, Li M, You Z, Gulizhaerkezi T, Wei S, Zhu A, Meng X
Brain research bulletin 2024 Jan;206:110838
Brain research bulletin 2024 Jan;206:110838
Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats.
Gao C, Wang Q, Ding Y, Kwong CHT, Liu J, Xie B, Wei J, Lee SMY, Mok GSP, Wang R
Nature communications 2024 Jan 6;15(1):328
Nature communications 2024 Jan 6;15(1):328
Near-infrared-responsive GE11-CuS@Gal nanoparticles as an intelligent drug release system for targeting therapy against oral squamous cell carcinoma.
Lan Q, Wang S, Chen Z, Hua J, Hu J, Luo S, Xu Y
International journal of pharmaceutics 2024 Jan 5;649:123667
International journal of pharmaceutics 2024 Jan 5;649:123667
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease.
Huang J, Zhang X, Yang X, Yv Q, Ye F, Chen S, Cui Y, Gu L, Zhu M, Li W
Chemico-biological interactions 2024 Jan 5;387:110820
Chemico-biological interactions 2024 Jan 5;387:110820
Knockdown of Smox protects the integrity of the blood-brain barrier through antioxidant effect and Nrf2 pathway activation in stroke.
Wang G, Li Z, Lin P, Zhang H, Wang Y, Zhang T, Wang H, Li H, Lin L, Zhao Y, Jia L, Chen Y, Ji H, Zhao W, Fu Z, Zhong Z
International immunopharmacology 2024 Jan 5;126:111183
International immunopharmacology 2024 Jan 5;126:111183
Targeting Keap1 with Inulae Herba activated the Nrf2 receptor to alleviate LPS-mediated acute lung injury.
Zhang J, Liu J, Liu JW, Zhu QM, Zhang M, Zhang R, Ma XC, Lv X, Yu ZL, Sun CP
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117358
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117358
Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities.
Wang R, Zeng J, Chen L, Sun L, Wang Y, Xu J, He X
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117265
Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway.
Xiao Y, Duan C, Gong P, Zhao Q, Wang XH, Geng F, Zeng J, Luo T, Xu Y, Zhao J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117152
Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis.
Wu W, Li G, Dong S, Huihan Chu C, Ma S, Zhang Z, Yuan S, Wu J, Guo Z, Shen Y, Wang J, Tang C
International immunopharmacology 2024 Jan 25;127:111423
International immunopharmacology 2024 Jan 25;127:111423
Bardoxolone methyl breaks the vicious cycle between M1 macrophages and senescent nucleus pulposus cells through the Nrf2/STING/NF-κB pathway.
Wang P, Zhang S, Liu W, Lv X, Wang B, Hu B, Shao Z
International immunopharmacology 2024 Jan 25;127:111262
International immunopharmacology 2024 Jan 25;127:111262
α-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice.
Yu H, Gan D, Luo Z, Yang Q, An D, Zhang H, Hu Y, Ma Z, Zeng Q, Xu D, Ren H
Molecular medicine (Cambridge, Mass.) 2024 Jan 22;30(1):15
Molecular medicine (Cambridge, Mass.) 2024 Jan 22;30(1):15
Perfluorocarbon Nanoparticles Incorporating Ginkgolide B: Artificial O(2) Carriers with Antioxidant Activity and Antithrombotic Effect.
Meng W, Ye H, Ma Z, Liu L, Zhang T, Han Q, Xiang Z, Xia Y, Ke Y, Guan X, Shi Q, Ataullakhanov FI, Panteleev M
ChemMedChem 2024 Jan 2;19(1):e202300312
ChemMedChem 2024 Jan 2;19(1):e202300312
Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2/HO-1 signaling pathway.
Peng C, Ai Q, Zhao F, Li H, Sun Y, Tang K, Yang Y, Chen N, Liu F
European journal of pharmacology 2024 Jan 15;963:176264
European journal of pharmacology 2024 Jan 15;963:176264
Natural Product Baohuoside I Impairs the Stability and Membrane Location of MRP2 Reciprocally Regulated by SUMOylation and Ubiquitination in Hepatocytes.
Zhao Z, Du JF, Wang QL, Qiu FN, Li P, Jiang Y, Li HJ
Chemical research in toxicology 2024 Jan 15;37(1):57-71
Chemical research in toxicology 2024 Jan 15;37(1):57-71
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Li Y, Li L, Xiong W, Duan X, Xi H
Theriogenology 2024 Jan 15;214:192-200
Theriogenology 2024 Jan 15;214:192-200
Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis.
Wu DZ, Zhu GZ, Zhao K, Gao JW, Cai GX, Li HZ, Huang YS, Tu C, Zhuang JS, Huang ZW, Zhong ZM
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Molecular medicine (Cambridge, Mass.) 2024 Jan 12;30(1):10
Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway.
Qin DE, Liang W, Yu Y, Whelan EC, Yuan X, Wang ZL, Wu XW, Cao ZR, Hua SY, Yin L, Shi L, Liang T
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Journal of ethnopharmacology 2024 Jan 10;318(Pt A):116906
Jujuboside B alleviates acetaminophen-induced hepatotoxicity in mice by regulating Nrf2-STING signaling pathway.
Wang HF, Xu JS, Zong K, Liang ZW, Li RF, Xue JF, Ding J, Zhao LS
Ecotoxicology and environmental safety 2024 Jan 1;269:115810
Ecotoxicology and environmental safety 2024 Jan 1;269:115810
4-octyl itaconate ameliorates ventilator-induced lung injury.
Wang X, Kong W, Yang R, Yang C
Archives of biochemistry and biophysics 2024 Feb;752:109853
Archives of biochemistry and biophysics 2024 Feb;752:109853
Fibroblast growth factor receptor-4 mediates activation of Nuclear Factor Erythroid 2-Related Factor-2 in gastric tumorigenesis.
Soutto M, Zhang X, Bhat N, Chen Z, Zhu S, Maacha S, Genoula M, El-Gazzaz O, Peng D, Lu H, McDonald OG, Chen XS, Cao L, Xu Z, El-Rifai W
Redox biology 2024 Feb;69:102998
Redox biology 2024 Feb;69:102998
Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma.
Zhao Y, Zhu S
Biochemical genetics 2024 Feb;62(1):144-155
Biochemical genetics 2024 Feb;62(1):144-155
Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide Poisoning.
Wang S, Xiong B, Tian Y, Hu Q, Jiang X, Zhang J, Chen L, Wang R, Li M, Zhou X, Zhang T, Ge H, Yu A
Molecular neurobiology 2024 Feb;61(2):1157-1174
Molecular neurobiology 2024 Feb;61(2):1157-1174
Silver nitroprusside as an efficient chemodynamic therapeutic agent and a peroxynitrite nanogenerator for targeted cancer therapies.
Asif K, Adeel M, Rahman MM, Sfriso AA, Bartoletti M, Canzonieri V, Rizzolio F, Caligiuri I
Journal of advanced research 2024 Feb;56:43-56
Journal of advanced research 2024 Feb;56:43-56
Protective effects of melatonin on DEHP-induced apoptosis and oxidative stress in prepubertal testes via the PI3K/AKT pathway.
Chen J, Zhao T, Zheng X, Kang L, Wang J, Wei Y, Wu Y, Shen L, Long C, Wei G, Wu S
Environmental toxicology 2024 Feb;39(2):952-964
Environmental toxicology 2024 Feb;39(2):952-964
Dimerized sesquiterpenoid [4 + 2] adducts with ferroptosis-promoting activity from Inula britannica Linn.
Guo C, Geng HJ, Wang WJ, Liu YX, Deng L, Tian JM, Gao JM, Tang JJ
Phytochemistry 2024 Feb;218:113951
Phytochemistry 2024 Feb;218:113951
Fluorene-9-bisphenol exposure damages the testis in mice through a novel mechanism of ferroptosis.
Feng Q, Liu Y, Zou L, Lei M, Zhu C, Xia W
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114385
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Feb;184:114385
Ferrostatin-1 Blunts Right Ventricular Hypertrophy and Dysfunction in Pulmonary Arterial Hypertension by Suppressing the HMOX1/GSH Signaling.
Song J, Chen Y, Chen Y, Wang S, Dong Z, Liu X, Li X, Zhang Z, Sun L, Zhong J
Journal of cardiovascular translational research 2024 Feb;17(1):183-196
Journal of cardiovascular translational research 2024 Feb;17(1):183-196
Visual identification of three kinds of human decidual tissues from elective termination of pregnancy.
Yin Z, Su J, Lu L, Yang L, Su S, Jiang X
Placenta 2024 Feb;146:89-100
Placenta 2024 Feb;146:89-100
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages.
Peng D, Huang Z, Yang H, Luo Y, Wu Z
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Immunity, inflammation and disease 2024 Feb;12(2):e1189
Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling.
Zhang JB, Wang F, Tang YT, Pang MZ, Li D, Liu CF
ACS chemical neuroscience 2024 Feb 7;15(3):572-581
ACS chemical neuroscience 2024 Feb 7;15(3):572-581
Synergistic suppression of ovarian cancer by combining NRF2 and GPX4 inhibitors: in vitro and in vivo evidence.
Li N, Jiang X, Zhang Q, Huang Y, Wei J, Zhang H, Luo H
Journal of ovarian research 2024 Feb 23;17(1):49
Journal of ovarian research 2024 Feb 23;17(1):49
P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.
Zheng Z, Shang X, Sun K, Hou Y, Zhang X, Xu J, Liu H, Ruan Z, Hou L, Guo Z, Wang G, Xu F, Guo F
Free radical biology & medicine 2024 Feb 20;212:336-348
Free radical biology & medicine 2024 Feb 20;212:336-348
Ezrin inhibition alleviates oxidative stress and pyroptosis via regulating TRPML1-calcineurin axis mediated enhancement of autophagy in spinal cord injury.
Lou J, Jin M, Zhou C, Fan Y, Ni L, Mao Y, Shen H, Li J, Zhang H, Fu C, Mao X, Chen Y, Zhong J, Zhou K, Wang L, Wu J
Free radical biology & medicine 2024 Feb 20;212:133-148
Free radical biology & medicine 2024 Feb 20;212:133-148
1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature.
Tonelotto V, Costa-Garcia M, O'Reilly E, Smith KF, Slater K, Dillon ET, Pendino M, Higgins C, Sist P, Bosch R, Passamonti S, Piulats JM, Villanueva A, Tramer F, Vanella L, Carey M, Kennedy BN
Cell death discovery 2024 Feb 10;10(1):70
Cell death discovery 2024 Feb 10;10(1):70
Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation.
Hu Y, Nan Y, Lin H, Zhao Q, Chen T, Tao X, Ding B, Lu L, Chen S, Zhu J, Guo X, Lin Z
Pediatric research 2024 Dec;96(7):1681-1692
Pediatric research 2024 Dec;96(7):1681-1692
Fluorescent gold nanoclusters possess multiple actions against atherosclerosis.
Lee YN, Wu YJ, Su CH, Wang BJ, Yang SH, Lee HI, Chou YH, Tien TY, Lin CF, Chan WH, Chung CH, Wang SW, Yeh HI
Redox biology 2024 Dec;78:103427
Redox biology 2024 Dec;78:103427
Corynoline alleviates hepatic ischemia-reperfusion injury by inhibiting NLRP3 inflammasome activation through enhancing Nrf2/HO-1 signaling.
Ge X, Gu Y, Wang W, Guo W, Wang P, Du P
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2069-2085
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Dec;73(12):2069-2085
TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2.
Li Y, Guo X, Zhan P, Huang S, Chen J, Zhou Y, Jiang W, Chen L, Lin Z
Inflammation 2024 Dec;47(6):2041-2056
Inflammation 2024 Dec;47(6):2041-2056
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway.
Du L, Guo C, Zeng S, Yu K, Liu M, Li Y
Renal failure 2024 Dec;46(2):2377785
Renal failure 2024 Dec;46(2):2377785
Nanoparticles transfected with plasmid-encoded lncRNA-OIP5-AS1 inhibit renal ischemia-reperfusion injury in mice via the miR-410-3p/Nrf2 axis.
Zhang R, Zhang X, Zhu X, Li T, Li Y, Zhang P, Chen Y, Li G, Han X
Renal failure 2024 Dec;46(1):2319327
Renal failure 2024 Dec;46(1):2319327
Sarmentosin alleviates doxorubicin-induced cardiotoxicity and ferroptosis via the p62-Keap1-Nrf2 pathway.
Lin Z, Wu C, Song D, Zhu C, Wu B, Wang J, Xue Y
Redox report : communications in free radical research 2024 Dec;29(1):2392329
Redox report : communications in free radical research 2024 Dec;29(1):2392329
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Zhang G, Wen F, Li Y, Sun P, Li Y, Hu Z, Wang H, Ma Y, Liang G, Chen L, Yang K, Hu J
Theriogenology 2024 Dec;230:330-340
Theriogenology 2024 Dec;230:330-340
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
Wang YQ, Dong YW, Qu HX, Qi JJ, Yan CX, Wei HK, Sun H, Sun BX, Liang S
Theriogenology 2024 Dec;230:203-211
Theriogenology 2024 Dec;230:203-211
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
Fang H, Xu M, Zhang J, Qin H, Tang H, He Y, Guo W
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
Electroacupuncture pretreatment maintains mitochondrial quality control via HO-1/MIC60 signaling pathway to alleviate endotoxin-induced acute lung injury.
Shi J, Piao M, Liu C, Yang J, Guan X, Liu H, Li Q, Zhang Y, Yu J
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167480
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167480
Protective Effect of Acteoside against Hydrogen Peroxide-Induced Oxidative Damage in Human Corneal Epithelial Cells.
Huang Y, Peng Q
Bulletin of experimental biology and medicine 2024 Dec;178(2):213-217
Bulletin of experimental biology and medicine 2024 Dec;178(2):213-217
Puerarin alleviates symptoms of preeclampsia through the repression of trophoblast ferroptosis via the CREB/HO-1 pathway.
Yue X, Pang M, Chen Y, Cheng Z, Zhou R, Wang Y, Zha Z, Huang L
Placenta 2024 Dec;158:145-155
Placenta 2024 Dec;158:145-155
Baliosperoid A attenuates lipopolysaccharide-induced acute lung injury by targeting SHP2 to inhibit inflammation and oxidative stress.
Li Y, Zhao L, Liu Z, Chen Y, Li X, Zhu D, Liu L
Bioorganic chemistry 2024 Dec;153:107982
Bioorganic chemistry 2024 Dec;153:107982
Design, green synthesis, and anti-glutamate damage screening of chalcone derivatives with spiro-heterocyclic structures as potential anti-ischemic brain and eye damage agents.
Wu J, Huang C, Ren S, Wu T, Li Y, Zhong H, Su T, Chen Y, Tan X, Wu W, Wang J, Li W
Bioorganic chemistry 2024 Dec;153:107870
Bioorganic chemistry 2024 Dec;153:107870
Discovery of novel 5-phenyl-1H-pyrrole-2-carboxylic acids as Keap1-Nrf2 inhibitors for acute lung injury treatment.
Tang J, Tie X, Zhi S, Wang Z, Zhao Q, Qu Z, Lu G, Li Q, Wu Y, Shi Y
Bioorganic chemistry 2024 Dec;153:107741
Bioorganic chemistry 2024 Dec;153:107741
M2 macrophage derived HMOX1 defines chronic rhinosinusitis with nasal polyps.
Wang E, Hao Y, Song J, Yuan J, Hong Y, Li Y, Wang Y, Wang C, Wang M, Zhang L
Clinical and translational allergy 2024 Dec;14(12):e70014
Clinical and translational allergy 2024 Dec;14(12):e70014
Dang-Gui-Bu-Xue decoction against diabetic nephropathy via modulating the carbonyl compounds metabolic profile and AGEs/RAGE pathway.
Zhang ZT, Qi Y, Chen P, Chen L, Jiang Y, Fan Z, Guan H, Bai L, Liu J, Zhao D, Yan G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156104
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156104
Role of hypoxia-inducible-factor-1α (HIF-1α) in ferroptosis of adipose tissue during ketosis.
Fan Y, Ma L, Fang X, Du S, Mauck J, Loor JJ, Sun X, Jia H, Xu C, Xu Q
Journal of dairy science 2024 Dec;107(12):10611-10627
Journal of dairy science 2024 Dec;107(12):10611-10627
Dietary Bacillus subtilis benefits meat quality by regulating the muscle fiber type and antioxidant capacity of broilers.
Wang H, Xiao C, Li J, Liang R, Liu Y, Song Z, Buyse J, Zhu L
Poultry science 2024 Dec;103(12):104267
Poultry science 2024 Dec;103(12):104267
The Novel Elemene Derivative, OMe-Ph-Elemene, Attenuates Oxidative Phosphorylation and Facilitates Apoptosis by Inducing Intracellular Reactive Oxygen Species.
Guo J, Wang J, Fan S, Gao M, Liu G, Xia Y
Antioxidants (Basel, Switzerland) 2024 Dec 9;13(12)
Antioxidants (Basel, Switzerland) 2024 Dec 9;13(12)
Gypenoside A-loaded mPEG-PLGA nanoparticles ameliorate high-glucose-induced retinal microvasculopathy by inhibiting ferroptosis.
Chen Q, Qiu FS, Xie W, Yu WY, Su ZA, Qin GM, Kang YK, Jiang SL, Yu CH
International journal of pharmaceutics 2024 Dec 5;666:124758
International journal of pharmaceutics 2024 Dec 5;666:124758
Albiflorin inhibits osteoclastogenesis and titanium particles-induced osteolysis via inhibition of ROS accumulation and the PI3K/AKT signaling pathway.
Wang Q, Tao H, Wang H, Chen K, Zhu P, Chen W, Shi F, Gu Y, Xu Y, Geng D
International immunopharmacology 2024 Dec 5;142(Pt B):113245
International immunopharmacology 2024 Dec 5;142(Pt B):113245
Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1α/HO-1 pathway.
Shi J, Song S, Wang Y, Wu K, Liang G, Wang A, Xu X
International immunopharmacology 2024 Dec 5;142(Pt A):113065
International immunopharmacology 2024 Dec 5;142(Pt A):113065
Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects.
Wu CY, Wang KQ, Qin YY, Wang HW, Wu MM, Zhu XD, Lu XY, Zhu MM, Lu CS, Hu QQ
International immunopharmacology 2024 Dec 25;143(Pt 2):113490
International immunopharmacology 2024 Dec 25;143(Pt 2):113490
Nicotinamide adenine dinucleotide phosphate alleviates intestinal ischemia/reperfusion injury via Nrf2/HO-1 pathway.
Chen SY, Xu H, Qin Y, He TQ, Shi RR, Xing YR, Xu J, Cong RC, Wang MR, Yang JS, Gu JH, He BS
International immunopharmacology 2024 Dec 25;143(Pt 2):113478
International immunopharmacology 2024 Dec 25;143(Pt 2):113478
Isolicoflavonol ameliorates acute liver injury via inhibiting NLRP3 inflammasome activation through boosting Nrf2 signaling in vitro and in vivo.
Zhang XJ, Pu YK, Yang PY, Wang MR, Zhang RH, Li XL, Xiao WL
International immunopharmacology 2024 Dec 25;143(Pt 1):113233
International immunopharmacology 2024 Dec 25;143(Pt 1):113233
Nrf2/NRF1 signaling activation and crosstalk amplify mitochondrial biogenesis in the treatment of triptolide-induced cardiotoxicity using calycosin.
Qi XM, Zhang WZ, Zuo YQ, Qiao YB, Zhang YL, Ren JH, Li QS
Cell biology and toxicology 2024 Dec 20;41(1):2
Cell biology and toxicology 2024 Dec 20;41(1):2
Celecoxib Combined with Tocilizumab Has Anti-Inflammatory Effects and Promotes the Recovery of Damaged Cartilage via the Nrf2/HO-1 Pathway In Vitro.
Shimasaki M, Ueda S, Sakurai M, Kawahara N, Ueda Y, Ichiseki T
Biomolecules 2024 Dec 20;14(12)
Biomolecules 2024 Dec 20;14(12)
miR-328-3p suppresses hepatocellular carcinoma progression by regulating HMOX1 expression.
Wang W, Li J, Pan C, Wang D, Dong J
Discover oncology 2024 Dec 2;15(1):735
Discover oncology 2024 Dec 2;15(1):735
Bexarotene ameliorated the pulmonary inflammation and M1 polarization of alveolar macrophages induced by cigarette smoke via PPARγ/HO-1.
Feng H, Li Z, Zheng R
Respiratory research 2024 Dec 18;25(1):431
Respiratory research 2024 Dec 18;25(1):431
4-Octyl itaconate inhibits vascular calcification partially via modulation of HMOX-1 signaling.
Dong Q, Liu F, Zhu J, Li M, Chen A, Feng L, Lan Z, Ye Y, Lu L, Liang Q, Yan J
European journal of pharmacology 2024 Dec 15;985:177122
European journal of pharmacology 2024 Dec 15;985:177122
Carbon dots encapsulated zeolitic imidazolate framework-8 as an enhanced multi-antioxidant for efficient cytoprotection to HK-2 cells.
Zhou S, Cai H, Tang Z, Lu S
Journal of colloid and interface science 2024 Dec 15;676:726-738
Journal of colloid and interface science 2024 Dec 15;676:726-738
Alantolactone improves cognitive impairment in rats with Porphyromonas gingivalis infection by inhibiting neuroinflammation, oxidative stress, and reducing Aβ levels.
Chen S, Han C, Wang X, Zhang Q, Yang X
Brain research 2024 Dec 15;1845:149203
Brain research 2024 Dec 15;1845:149203
Discovery of the synergy between sulindac and NO expands the application of NSAIDs in cardiac complications.
Zhou W, Jiang P, Wang C, Gou S
Bioorganic & medicinal chemistry 2024 Dec 15;116:117991
Bioorganic & medicinal chemistry 2024 Dec 15;116:117991
Melatonin attenuates hepatic oxidative stress by regulating the P62/LC3 autophagy pathway in PCOS.
Zhang J, Zhang H, Guo B, Yang J, Yu R, Chen W, Zhai M, Yuhan C, Liu Y, Hong Q, Xie F
Endocrine connections 2024 Dec 1;13(12)
Endocrine connections 2024 Dec 1;13(12)
Activating MC4R Promotes Functional Recovery by Repressing Oxidative Stress-Mediated AIM2 Activation Post-spinal Cord Injury.
Wang Y, Fang N, Wang Y, Geng Y, Li Y
Molecular neurobiology 2024 Aug;61(8):6101-6118
Molecular neurobiology 2024 Aug;61(8):6101-6118
HO-1-induced autophagy establishes a HO-1-p62-Nrf2 positive feedback loop to reduce gut permeability in cholestatic liver disease.
Ren P, Lei W, Zhao C, Duan Z
Scandinavian journal of gastroenterology 2024 Aug;59(8):906-917
Scandinavian journal of gastroenterology 2024 Aug;59(8):906-917
Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.
Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T
Journal of gastroenterology 2024 Aug;59(8):682-698
Journal of gastroenterology 2024 Aug;59(8):682-698
Curcumin inhibits PAT-induced renal ferroptosis via the p62/Keap1/Nrf2 signalling pathway.
Zhai J, Chen Z, Zhu Q, Guo Z, Sun X, Jiang L, Li J, Wang N, Yao X, Zhang C, Deng H, Wang S, Yang G
Toxicology 2024 Aug;506:153863
Toxicology 2024 Aug;506:153863
Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis.
Zhou Y, Yang Y, Yi L, Pan M, Tang W, Duan H
Neurochemical research 2024 Aug;49(8):2131-2147
Neurochemical research 2024 Aug;49(8):2131-2147
Ezetimibe ketone protects against renal ischemia-reperfusion injury and attenuates oxidative stress via activation of the Nrf2/HO-1 signaling pathway.
Chen Z, Wang K, He X, Xue D, Ma X
Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23792
Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23792
CRHR1 antagonist alleviated depression-like behavior by downregulating p62 in a rat model of post-stroke depression.
Liu H, Zhang Y, Hou X, Zhu C, Yang Q, Li K, Fan L, Zhang X, Jiang X, Jin X, Lei H, Chen T, Zhang F, Zhang Z, Song J
Experimental neurology 2024 Aug;378:114822
Experimental neurology 2024 Aug;378:114822
Nrf2 activation by pyrroloquinoline quinone inhibits natural aging-related intervertebral disk degeneration in mice.
Xue Q, Li J, Qin R, Li M, Li Y, Zhang J, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2024 Aug;23(8):e14202
Aging cell 2024 Aug;23(8):e14202
Casticin induces ferroptosis in human osteosarcoma cells through Fe(2+) overload and ROS production mediated by HMOX1 and LC3-NCOA4.
Jiwa H, Xie Z, Qu X, Xu J, Huang Y, Huang X, Zhang J, Wang N, Li N, Luo J, Luo X
Biochemical pharmacology 2024 Aug;226:116346
Biochemical pharmacology 2024 Aug;226:116346
Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways.
Liang W, Yang H, Pan L, Wei S, Li Z, Zhang P, Li R, Wu Y, Liu M, Liu X
Applied biochemistry and biotechnology 2024 Aug;196(8):4807-4822
Applied biochemistry and biotechnology 2024 Aug;196(8):4807-4822
Changes in PI3K/AKT and NRF2/HO-1 signaling expression and intestinal microbiota in bleomycin-induced pulmonary fibrosis.
Li C, Cao Y, Peng Y, Ma T, Wu F, Hua Y, Wang X, Bai T, Wei Y, Ji P
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114796
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Aug;190:114796
Polystyrene microplastics exposure reduces meat quality and disturbs skeletal muscle angiogenesis via thrombospondin 1.
Yang Y, Liu H, Zou D, Ji F, Lv R, Wu H, Zhou H, Ren A, Xu T, Hou G, Hu C
Food research international (Ottawa, Ont.) 2024 Aug;190:114581
Food research international (Ottawa, Ont.) 2024 Aug;190:114581
Phenylsulfate-induced oxidative stress and mitochondrial dysfunction in podocytes are ameliorated by Astragaloside IV activation of the SIRT1/PGC1α /Nrf1 signaling pathway.
Li L, Zou J, Zhou M, Li H, Zhou T, Liu X, Huang Q, Yang S, Xiang Q, Yu R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117008
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117008
miR-200a-3p-enriched MSC-derived extracellular vesicles reverse erectile function in diabetic rats by targeting Keap1.
Zhang J, Zhao D, Zang Z, Ruan Z, Fu Q, Zhang K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116964
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116964
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Cao H, Zhao L, Yuan Y, Liao C, Zeng W, Li A, Huang Q, Zhao Y, Fan Y, Jiang L, Song D, Li S, Zhang B
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
A clinical-stage Nrf2 activator suppresses osteoclast differentiation via the iron-ornithine axis.
Dong Y, Kang H, Peng R, Liu Z, Liao F, Hu SA, Ding W, Wang P, Yang P, Zhu M, Wang S, Wu M, Ye D, Gan X, Li F, Song K
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
Cell metabolism 2024 Aug 6;36(8):1679-1695.e6
Potential mechanism prediction of indole-3-propionic acid against diminished ovarian reserve via network pharmacology, molecular docking and experimental verification.
Liu A, Liu Z, Shen H, Du W, Jiang Y, Wang L, Zhang R, Jin P, Zhang X
BMC complementary medicine and therapies 2024 Aug 27;24(1):316
BMC complementary medicine and therapies 2024 Aug 27;24(1):316
Combining Multiple Omics with Molecular Dynamics Reveals SCP2-Mediated Cytotoxicity Effects of Aflatoxin B1 in SW480 Cells.
Chen M, Wen J, Qiu Y, Gao X, Zhang J, Lin Y, Wu Z, Lin X, Zhu A
Toxins 2024 Aug 24;16(9)
Toxins 2024 Aug 24;16(9)
Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy.
Yang S, Zhu Y, Shi Y, Su S, Liang H, Li S, Wu Z, Miao J, Chen Y, Zhang X, Wang X
Free radical biology & medicine 2024 Aug 20;221:245-256
Free radical biology & medicine 2024 Aug 20;221:245-256
Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity.
Ye C, Yan C, Bian SJ, Li XR, Li Y, Wang KX, Zhu YH, Wang L, Wang YC, Wang YY, Li TS, Qi SH, Luo L
Journal of nanobiotechnology 2024 Aug 2;22(1):464
Journal of nanobiotechnology 2024 Aug 2;22(1):464
The involvement of the Stat1/Nrf2 pathway in exacerbating Crizotinib-induced liver injury: implications for ferroptosis.
Guo L, Ma J, Xiao M, Liu J, Hu Z, Xia S, Li N, Yang Y, Gong H, Xi Y, Fu R, Jiang P, Xia C, Lauschke VM, Yan M
Cell death & disease 2024 Aug 19;15(8):600
Cell death & disease 2024 Aug 19;15(8):600
Inhaled tea polyphenol-loaded nanoparticles coated with platelet membranes largely attenuate asthmatic inflammation.
Ouyang S, Lu P, Li J, Jin H, Wu W, Luo R, Wang B, Huang X, Lian X, Huang G
Respiratory research 2024 Aug 17;25(1):311
Respiratory research 2024 Aug 17;25(1):311
Mesenchymal stem cell-derived extracellular vesicles mitigate neuronal damage from intracerebral hemorrhage by modulating ferroptosis.
Yang Y, Gao L, Xi J, Liu X, Yang H, Luo Q, Xie F, Niu J, Meng P, Tian X, Wu X, Long Q
Stem cell research & therapy 2024 Aug 13;15(1):255
Stem cell research & therapy 2024 Aug 13;15(1):255
EGCG-NPs inhibition HO-1-mediated reprogram iron metabolism against ferroptosis after subarachnoid hemorrhage.
Huang L, Wang X, Zheng Y, Lang D, Wang J, Yan S, Chen Y
Redox biology 2024 Apr;70:103075
Redox biology 2024 Apr;70:103075
SIRT5 Regulates Ferroptosis through the Nrf2/HO-1 Signaling Axis to Participate in Ischemia-Reperfusion Injury in Ischemic Stroke.
Li J, Wei G, Song Z, Chen Z, Gu J, Zhang L, Wang Z
Neurochemical research 2024 Apr;49(4):998-1007
Neurochemical research 2024 Apr;49(4):998-1007
Exosomes derived from bone marrow mesenchymal stem cells alleviate biliary ischemia reperfusion injury in fatty liver transplantation by inhibiting ferroptosis.
Tian X, Wu L, Li X, Zheng W, Zuo H, Song H
Molecular and cellular biochemistry 2024 Apr;479(4):881-894
Molecular and cellular biochemistry 2024 Apr;479(4):881-894
Icariin alleviates renal inflammation and tubulointerstitial fibrosis via Nrf2-mediated attenuation of mitochondrial damage.
Ding N, Sun S, Zhou S, Lv Z, Wang R
Cell biochemistry and function 2024 Apr;42(3):e4005
Cell biochemistry and function 2024 Apr;42(3):e4005
SESN2-Mediated AKT/GSK-3β/NRF2 Activation to Ameliorate Adriamycin Cardiotoxicity in High-Fat Diet-Induced Obese Mice.
Gao T, Wang J (b), Xiao M, Wang J (a), Wang S, Tang Y, Zhang J, Lu G, Guo H, Guo Y, Liu Q, Li J, Gu J
Antioxidants & redox signaling 2024 Apr;40(10-12):598-615
Antioxidants & redox signaling 2024 Apr;40(10-12):598-615
CD44-targeted melanin-based nanoplatform for alleviation of ischemia/reperfusion-induced acute kidney injury.
Sun J, Zhao X, Shen H, Dong J, Rong S, Cai W, Zhang R
Journal of controlled release : official journal of the Controlled Release Society 2024 Apr;368:1-14
Journal of controlled release : official journal of the Controlled Release Society 2024 Apr;368:1-14
Roles of heat shock protein A12A in the development of diabetic cardiomyopathy.
Jia Y, Yu Y, Gao C, Li Y, Li C, Ding Z, Kong Q, Liu L
Cell stress & chaperones 2024 Apr;29(2):272-284
Cell stress & chaperones 2024 Apr;29(2):272-284
A snake cathelicidin enhances transcription factor EB-mediated autophagy and alleviates ROS-induced pyroptosis after ischaemia-reperfusion injury of island skin flaps.
Yang N, Yu G, Lai Y, Zhao J, Chen Z, Chen L, Fu Y, Fang P, Gao W, Cai Y, Li Z, Xiao J, Zhou K, Ding J
British journal of pharmacology 2024 Apr;181(7):1068-1090
British journal of pharmacology 2024 Apr;181(7):1068-1090
Phenolics and terpenoids with good anti-inflammatory activity from the fruits of Amomum villosum and the anti-inflammatory mechanism of active diterpene.
Xu Y, Sun D, Xiong L, Zhang Z, Li Y, Liu K, Li H, Chen L
Bioorganic chemistry 2024 Apr;145:107190
Bioorganic chemistry 2024 Apr;145:107190
Tiliroside attenuates acute kidney injury by inhibiting ferroptosis through the disruption of NRF2-KEAP1 interaction.
Cai F, Li D, Zhou K, Zhang W, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155407
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155407
Co-catalpol alleviates fluoxetine-induced main toxicity: Involvement of ATF3/FSP1 signaling-mediated inhibition of ferroptosis.
Wu X, Guan Y, Wang J, Song L, Zhang Y, Wang Y, Li Y, Qin L, He Q, Zhang T, Long B, Ji L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155340
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155340
H(2)S-Releasing Versatile Montmorillonite Nanoformulation Trilogically Renovates the Gut Microenvironment for Inflammatory Bowel Disease Modulation.
Jin T, Lu H, Zhou Q, Chen D, Zeng Y, Shi J, Zhang Y, Wang X, Shen X, Cai X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2308092
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2308092
Hesperidin ameliorates H(2)O(2)-induced bovine mammary epithelial cell oxidative stress via the Nrf2 signaling pathway.
Huang Q, Liu J, Peng C, Han X, Tan Z
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
Journal of animal science and biotechnology 2024 Apr 9;15(1):57
Guben Qingfei decoction attenuates LPS-induced acute lung injury by modulating the TLR4/NF-κB and Keap1/Nrf2 signaling pathways.
Zeng Z, Fu Y, Li M, Shi Y, Ding Q, Chen S
Journal of ethnopharmacology 2024 Apr 6;323:117674
Journal of ethnopharmacology 2024 Apr 6;323:117674
Protective effects of Huang-Qi-Ge-Gen decoction against diabetic liver injury through regulating PI3K/AKT/Nrf2 pathway and metabolic profiling.
Zhang ZT, Liang QF, Wang X, Wang RS, Duan TT, Wang SM, Tang D
Journal of ethnopharmacology 2024 Apr 6;323:117647
Journal of ethnopharmacology 2024 Apr 6;323:117647
Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.
Kong M, Zhou J, Kang A, Kuai Y, Xu H, Li M, Miao X, Guo Y, Fan Z, Xu Y, Li Z
Gut 2024 Apr 5;73(5):810-824
Gut 2024 Apr 5;73(5):810-824
The role of FPR2-mediated ferroptosis in formyl peptide-induced acute lung injury against endothelial barrier damage and protective effect of the mitochondria-derived peptide MOTS-c.
Wen Z, Fan J, Zhan F, Li X, Li B, Lu P, Yao X, Shen Z, Liu Z, Wang C, Li X, Jin W, Zhang X, Qi Y, Wang X, Song M
International immunopharmacology 2024 Apr 20;131:111911
International immunopharmacology 2024 Apr 20;131:111911
Physalin H ameliorates LPS-induced acute lung injury via KEAP1/NRF2 axis.
Cai Y, Zhu J, Zhu L, Hong L, Zhang J, Kong L, Chen C, Luo J
International immunopharmacology 2024 Apr 20;131:111789
International immunopharmacology 2024 Apr 20;131:111789
Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway.
Wang Z, Dong Z, Li Y, Jiao X, Liu Y, Chang H, Gan Y
Biomedicines 2024 Apr 18;12(4)
Biomedicines 2024 Apr 18;12(4)
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Quercetin Ameliorates Diabetic Kidney Injury by Inhibiting Ferroptosis via Activating Nrf2/HO-1 Signaling Pathway.
Feng Q, Yang Y, Qiao Y, Zheng Y, Yu X, Liu F, Wang H, Zheng B, Pan S, Ren K, Liu D, Liu Z
The American journal of Chinese medicine 2023;51(4):997-1018
The American journal of Chinese medicine 2023;51(4):997-1018
Maslinic Acid Ameliorates Myocardial Ischemia Reperfusion Injury-Induced Oxidative Stress via Activating Nrf2 and Inhibiting NF-[Formula: see text]B Pathways.
Li Q, Li Z, Liu C, Xu M, Li T, Wang Y, Feng J, Yin X, Du X, Lu C
The American journal of Chinese medicine 2023;51(4):929-951
The American journal of Chinese medicine 2023;51(4):929-951
Exploring the role of Hmox1 in ferroptosis and immune infiltration during renal ischemia-reperfusion injury.
Luo J, Pei J, Yu CJ, Tian XM, Zhang J, Shen LJ, Hua Y, Wei GH
Renal failure 2023;45(2):2257801
Renal failure 2023;45(2):2257801
Ergolide mediates anti-cancer effects on metastatic uveal melanoma cells and modulates their cellular and extracellular vesicle proteomes.
Sundaramurthi H, Tonelotto V, Wynne K, O'Connell F, O'Reilly E, Costa-Garcia M, Kovácsházi C, Kittel A, Marcone S, Blanco A, Pallinger E, Hambalkó S, Piulats Rodriguez JM, Ferdinandy P, O'Sullivan J, Matallanas D, Jensen LD, Giricz Z, Kennedy BN
Open research Europe 2023;3:88
Open research Europe 2023;3:88
Detection of Ferroptosis by Immunohistochemistry and Immunofluorescence.
Zhong X, Chen R
Methods in molecular biology (Clifton, N.J.) 2023;2712:211-222
Methods in molecular biology (Clifton, N.J.) 2023;2712:211-222
Fisetin Ameliorates Diabetic Nephropathy-Induced Podocyte Injury by Modulating Nrf2/HO-1/GPX4 Signaling Pathway.
Qian X, Lin S, Li J, Jia C, Luo Y, Fan R, Hu C, Chen Y
Evidence-based complementary and alternative medicine : eCAM 2023;2023:9331546
Evidence-based complementary and alternative medicine : eCAM 2023;2023:9331546
Curcumin Induces Ferroptosis in Follicular Thyroid Cancer by Upregulating HO-1 Expression.
Chen H, Li Z, Xu J, Zhang N, Chen J, Wang G, Zhao Y
Oxidative medicine and cellular longevity 2023;2023:6896790
Oxidative medicine and cellular longevity 2023;2023:6896790
Protective Effect of Alkaline Mineral Water on Calcium Oxalate-Induced Kidney Injury in Mice.
Liu L, Lin C, Li X, Cheng Y, Wang R, Luo C, Zhao X, Jiang Z
Evidence-based complementary and alternative medicine : eCAM 2023;2023:4559802
Evidence-based complementary and alternative medicine : eCAM 2023;2023:4559802
Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis.
Sun R, Zhu J, Sun K, Gao L, Zheng B, Shi J
International journal of medical sciences 2023;20(13):1679-1697
International journal of medical sciences 2023;20(13):1679-1697
FGF2 Alleviates Microvascular Ischemia-Reperfusion Injury by KLF2-mediated Ferroptosis Inhibition and Antioxidant Responses.
Chen F, Zhan J, Liu M, Mamun AA, Huang S, Tao Y, Zhao J, Zhang Y, Xu Y, He Z, Du S, Lu W, Li X, Chen Z, Xiao J
International journal of biological sciences 2023;19(13):4340-4359
International journal of biological sciences 2023;19(13):4340-4359
Evaluation of arsenic metabolism and tight junction injury after exposure to arsenite and monomethylarsonous acid using a rat in vitro blood-Brain barrier model.
Yamauchi H, Hitomi T, Takata A
PloS one 2023;18(11):e0295154
PloS one 2023;18(11):e0295154
Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis.
Yan Y, Yu L, Chen B, Cao C, Zhao H, Wang Q, Xie D, Xi Y, Zhang C, Cheng J
Journal of inflammation research 2023;16:6179-6193
Journal of inflammation research 2023;16:6179-6193
Resolvin D1 Attenuates Inflammation and Pelvic Pain Associated with EAP by Inhibiting Oxidative Stress and NLRP3 Inflammasome Activation via the Nrf2/HO-1 Pathway.
Zhang J, Chen J, Jiang Q, Feng R, Zhao X, Li H, Yang C, Hua X
Journal of inflammation research 2023;16:3365-3379
Journal of inflammation research 2023;16:3365-3379
Mechanism of Wuzhuyu decoction on alcohol-induced gastric ulcers using integrated network analysis and metabolomics.
Wang X, Chen L, Chang L, He Y, He T, Wang R, Wei S, Jing M, Zhou X, Li H, Zhao Y
Frontiers in pharmacology 2023;14:1308995
Frontiers in pharmacology 2023;14:1308995
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.
Chen T, Hu Y, Lu L, Zhao Q, Tao X, Ding B, Chen S, Zhu J, Guo X, Lin Z
Frontiers in pharmacology 2023;14:1134464
Frontiers in pharmacology 2023;14:1134464
Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis.
Liu X, Peng X, Cen S, Yang C, Ma Z, Shi X
Frontiers in pharmacology 2023;14:1129662
Frontiers in pharmacology 2023;14:1129662
Resolvin D1/N-formyl peptide receptor 2 ameliorates paclitaxel-induced neuropathic pain through the activation of IL-10/Nrf2/HO-1 pathway in mice.
Su CJ, Zhang JT, Zhao FL, Xu DL, Pan J, Liu T
Frontiers in immunology 2023;14:1091753
Frontiers in immunology 2023;14:1091753
Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway.
Lou L, Wang M, He J, Yang S, Meng F, Wang S, Jin X, Cai J, Cai C
Frontiers in pharmacology 2023;14:1067402
Frontiers in pharmacology 2023;14:1067402
Fangchinoline alleviates cognitive impairments through enhancing autophagy and mitigating oxidative stress in Alzheimer's disease models.
Yi L, Luo M, Wang M, Dong Z, Du Y
Frontiers in cell and developmental biology 2023;11:1288506
Frontiers in cell and developmental biology 2023;11:1288506
Phellodendronoside A Exerts Anticancer Effects Depending on Inducing Apoptosis Through ROS/Nrf2/Notch Pathway and Modulating Metabolite Profiles in Hepatocellular Carcinoma.
Si Y, Hui C, Guo T, Liu M, Chen X, Dong C, Feng S
Journal of hepatocellular carcinoma 2023;10:935-948
Journal of hepatocellular carcinoma 2023;10:935-948
Epigallocatechin gallate alleviates mono-2-ethylhexyl phthalate-induced male germ cell pyroptosis by inhibiting the ROS/mTOR/NLRP3 pathway.
Hong Y, Zhou X, Li Q, Chen J, Wei Y, Shen L, Long C, Wu S, Wei G
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105626
Toxicology in vitro : an international journal published in association with BIBRA 2023 Sep;91:105626
Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis.
Yokote A, Imazu N, Umeno J, Kawasaki K, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki K, Akashi K, Kitazono T, Torisu T
Journal of gastroenterology 2023 Sep;58(9):868-882
Journal of gastroenterology 2023 Sep;58(9):868-882
Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress.
Li X, Yi L, Liu X, Chen X, Chen S, Cai S
Transplantation proceedings 2023 Sep;55(7):1751-1761
Transplantation proceedings 2023 Sep;55(7):1751-1761
Effect of renal denervation on cardiac remodelling and function in rats with chronic intermittent hypoxia.
Lu D, Wang K, Jiang W, Zhang H, Zhang H
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):719-727
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):719-727
Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.
Li J, Zhang J, Xue Q, Liu B, Qin R, Li Y, Qiu Y, Wang R, Goltzman D, Miao D, Yang R
Aging cell 2023 Sep;22(9):e13912
Aging cell 2023 Sep;22(9):e13912
Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke.
Wang J, He P, Tian Q, Luo Y, He Y, Liu C, Gong P, Guo Y, Ye Q, Li M
Neural regeneration research 2023 Sep;18(9):2029-2036
Neural regeneration research 2023 Sep;18(9):2029-2036
Activation of Nrf2 inhibits ferroptosis and protects against oxaliplatin-induced ototoxicity.
Xu K, Chang X, Bai X, Liu HB, Chen XB, Chen HP, Liu YH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115248
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115248
Ozone pretreatment alleviates ischemiareperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis.
Ding S, Duanmu X, Xu L, Zhu L, Wu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115185
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115185
Milk-derived exosomes carrying siRNA-KEAP1 promote diabetic wound healing by improving oxidative stress.
Xiang X, Chen J, Jiang T, Yan C, Kang Y, Zhang M, Xiang K, Guo J, Jiang G, Wang C, XiangXu, Yang X, Chen Z
Drug delivery and translational research 2023 Sep;13(9):2286-2296
Drug delivery and translational research 2023 Sep;13(9):2286-2296
Artesunate alleviates intestinal ischemia/reperfusion induced acute lung injury via up-regulating AKT and HO-1 signal pathway in mice.
Ji T, Chen M, Liu Y, Jiang H, Li N, He X
International immunopharmacology 2023 Sep;122:110571
International immunopharmacology 2023 Sep;122:110571
Small extracellular vesicles from HO-1-modified bone marrow-derived mesenchymal stem cells attenuate ischemia-reperfusion injury after steatotic liver transplantation by suppressing ferroptosis via miR-214-3p.
Zuo H, Wang Y, Yuan M, Zheng W, Tian X, Pi Y, Zhang X, Song H
Cellular signalling 2023 Sep;109:110793
Cellular signalling 2023 Sep;109:110793
FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male mice.
Tong G, Chen Y, Chen X, Fan J, Zhu K, Hu Z, Li S, Zhu J, Feng J, Wu Z, Hu Z, Zhou B, Jin L, Chen H, Shen J, Cong W, Li X
Nature communications 2023 Sep 30;14(1):6107
Nature communications 2023 Sep 30;14(1):6107
Antidiabetic Effect of Collagen Peptides from Harpadon nehereus Bones in Streptozotocin-Induced Diabetes Mice by Regulating Oxidative Stress and Glucose Metabolism.
Lin Q, Guo Y, Li J, He S, Chen Y, Jin H
Marine drugs 2023 Sep 29;21(10)
Marine drugs 2023 Sep 29;21(10)
Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer.
Deng C, Xiong L, Chen Y, Wu K, Wu J
BMC pulmonary medicine 2023 Sep 25;23(1):360
BMC pulmonary medicine 2023 Sep 25;23(1):360
Exploring anti-acute kidney injury mechanism of Dahuang-Gancao decoction by network pharmacology and experimental validation.
Wang R, An Y, Xu Y, Li C, Wang Q, Zou Y, Wang G
Aging 2023 Sep 18;15(19):10072-10088
Aging 2023 Sep 18;15(19):10072-10088
Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis.
Hou L, Wang G, Zhang X, Lu F, Xu J, Guo Z, Lin J, Zheng Z, Liu H, Hou Y, Sun K, Guo F
iScience 2023 Sep 15;26(9):107647
iScience 2023 Sep 15;26(9):107647
Protective Effects of ζ-Carotene-like Compounds against Acute UVB-Induced Skin Damage.
Zhang L, Liang S, Zhang Z, Wang K, Cao J, Yao M, Qin L, Qu C, Miao J
International journal of molecular sciences 2023 Sep 12;24(18)
International journal of molecular sciences 2023 Sep 12;24(18)
LYVE-1(+) macrophages form a collaborative CCR5-dependent perivascular niche that influences chemotherapy responses in murine breast cancer.
Anstee JE, Feehan KT, Opzoomer JW, Dean I, Muller HP, Bahri M, Cheung TS, Liakath-Ali K, Liu Z, Choy D, Caron J, Sosnowska D, Beatson R, Muliaditan T, An Z, Gillett CE, Lan G, Zou X, Watt FM, Ng T, Burchell JM, Kordasti S, Withers DR, Lawrence T, Arnold JN
Developmental cell 2023 Sep 11;58(17):1548-1561.e10
Developmental cell 2023 Sep 11;58(17):1548-1561.e10
Omentin-1 ameliorates experimental inflammatory bowel disease via Nrf2 activation and redox regulation.
Tao M, Yan W, Chen C, Tang M, Zhao X, Feng Q, Fei X, Fu Y
Life sciences 2023 Sep 1;328:121847
Life sciences 2023 Sep 1;328:121847
Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis.
Huang Y, Yang W, Yang L, Wang T, Li C, Yu J, Zhang P, Yin Y, Li R, Tao K
Scientific reports 2023 Sep 1;13(1):14359
Scientific reports 2023 Sep 1;13(1):14359
Graphene oxide had adverse effects on sperm motility and morphology through oxidative stress.
Chen Q, Li L, Zhao J, Zhang Y, Xue X
Toxicology in vitro : an international journal published in association with BIBRA 2023 Oct;92:105653
Toxicology in vitro : an international journal published in association with BIBRA 2023 Oct;92:105653
Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia-reperfusion injury model of mice.
Wang ZS, Shu B, Han Q, Li GH, Guo YL
International urology and nephrology 2023 Oct;55(10):2599-2610
International urology and nephrology 2023 Oct;55(10):2599-2610
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.
Wang X, Yang J, Wang W, Li Y, Yang Y
Immunopharmacology and immunotoxicology 2023 Oct;45(5):527-538
Immunopharmacology and immunotoxicology 2023 Oct;45(5):527-538
TMED2 Induces Cisplatin Resistance in Breast Cancer via Targeting the KEAP1-Nrf2 Pathway.
Liang C, Zhang HY, Wang YQ, Yang LA, Du YS, Luo Y, Zhang TC, Xu Y
Current medical science 2023 Oct;43(5):1023-1032
Current medical science 2023 Oct;43(5):1023-1032
NRF2 Antagonizes HIV-1 Tat and Methamphetamine-Induced BV2 Cell Ferroptosis by Regulating SLC7A11.
Lin S, Cheng H, Yang G, Wang C, Leung CK, Zhang S, Tan Y, Zhang H, Wang H, Miao L, Li Y, Huang Y, Li J, Zhang R, Zeng X
Neurotoxicity research 2023 Oct;41(5):398-407
Neurotoxicity research 2023 Oct;41(5):398-407
Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase.
Liu L, Zhang Y, Wang L, Liu Y, Chen H, Hu Q, Xie C, Meng X, Shen X
Phytotherapy research : PTR 2023 Oct;37(10):4587-4606
Phytotherapy research : PTR 2023 Oct;37(10):4587-4606
Febuxostat ameliorates APAP-induced acute liver injury by activating Keap1/Nrf2 and inhibiting TLR4/NF-κB p65 pathways.
Tian J, Zhang S, Li L, Lin X, Li Y, Zhao K, Zheng F, Chen Y, Yang Y, Wu T, Pang J
Experimental biology and medicine (Maywood, N.J.) 2023 Oct;248(20):1864-1876
Experimental biology and medicine (Maywood, N.J.) 2023 Oct;248(20):1864-1876
Effects of dietary resveratrol supplementation in cattle on the anti-oxidative capacity and meat quality of beef steaks under high‑oxygen packaging.
Cui Y, Qi J, Li J, Zhang Y, Yang X, Xin L, Niu L, Xu B, Qian Z, Zhu L, Liang R
Meat science 2023 Oct;204:109238
Meat science 2023 Oct;204:109238
MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis.
Li C, Han S, Zhu J, Cheng F
Cellular signalling 2023 Oct;110:110801
Cellular signalling 2023 Oct;110:110801
Puerarin protects against acetaminophen-induced oxidative damage in liver through activation of the Keap1/Nrf2 signaling pathway.
Zhou W, He H, Wei Q, Che L, Zhao X, Liu W, Yan Y, Hu L, Du Y, Yin Z, Shuai Y, Yang L, Feng R
Food science & nutrition 2023 Oct;11(10):6604-6615
Food science & nutrition 2023 Oct;11(10):6604-6615
Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity.
Chen X, Liu C, Zhao H, Zhong Y, Xu Y, Wang Y
Biology direct 2023 Oct 9;18(1):63
Biology direct 2023 Oct 9;18(1):63
Rosmarinic acid treatment protects against lethal H1N1 virus-mediated inflammation and lung injury by promoting activation of the h-PGDS-PGD(2)-HO-1 signal axis.
Zhou B, Wang L, Yang S, Liang Y, Zhang Y, Pan X, Li J
Chinese medicine 2023 Oct 27;18(1):139
Chinese medicine 2023 Oct 27;18(1):139
Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis.
Liu Y, Cui H, Mei C, Cui M, He Q, Wang Q, Li D, Song Y, Li J, Chen S, Zhu C
Cell death & disease 2023 Oct 21;14(10):694
Cell death & disease 2023 Oct 21;14(10):694
A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy.
Kou B, Jiang Y, Chen Y, Yang J, Sun J, Yan Y, Weng L, Xiao C
Molecules (Basel, Switzerland) 2023 Oct 17;28(20)
Molecules (Basel, Switzerland) 2023 Oct 17;28(20)
Dankasterone A induces prostate cancer cell death by inducing oxidative stress.
Gan X, Nie M, Cai S, Liu Y, Zhang F, Feng X, Li Y, Yang B, Wang X
European journal of pharmacology 2023 Oct 15;957:175988
European journal of pharmacology 2023 Oct 15;957:175988
Scutellarin attenuates oxidative stress and neuroinflammation in cerebral ischemia/reperfusion injury through PI3K/Akt-mediated Nrf2 signaling pathways.
Xie X, Wang F, Ge W, Meng X, Fan L, Zhang W, Wang Z, Ding M, Gu S, Xing X, Sun X
European journal of pharmacology 2023 Oct 15;957:175979
European journal of pharmacology 2023 Oct 15;957:175979
Injectable microenvironment-responsive hydrogels with redox-activatable supramolecular prodrugs mediate ferroptosis-immunotherapy for postoperative tumor treatment.
Cheng Z, Xue C, Liu M, Cheng Z, Tian G, Li M, Xue R, Yao X, Zhang Y, Luo Z
Acta biomaterialia 2023 Oct 1;169:289-305
Acta biomaterialia 2023 Oct 1;169:289-305
Taxifolin protects against doxorubicin-induced cardiotoxicity and ferroptosis by adjusting microRNA-200a-mediated Nrf2 signaling pathway.
Lin Z, Wang J
Heliyon 2023 Nov;9(11):e22011
Heliyon 2023 Nov;9(11):e22011
The extract from Portulaca oleracea L. rehabilitates skin photoaging via adjusting miR-138-5p/Sirt1-mediated inflammation and oxidative stress.
Qu L, Wang F, Ma X
Heliyon 2023 Nov;9(11):e21955
Heliyon 2023 Nov;9(11):e21955
Heme Oxygenase-1-Modified BMMSCs Activate AMPK-Nrf2-FTH1 to Reduce Severe Steatotic Liver Ischemia-Reperfusion Injury.
Tian X, Wang Y, Yuan M, Zheng W, Zuo H, Zhang X, Song H
Digestive diseases and sciences 2023 Nov;68(11):4196-4211
Digestive diseases and sciences 2023 Nov;68(11):4196-4211
Fullerol rescues the light-induced retinal damage by modulating Müller glia cell fate.
Cha Z, Yin Z, A L, Ge L, Yang J, Huang X, Gao H, Chen X, Feng Z, Mo L, He J, Zhu S, Zhao M, Tao Z, Gu Z, Xu H
Redox biology 2023 Nov;67:102911
Redox biology 2023 Nov;67:102911
T-2 toxin induces cardiotoxicity by activating ferroptosis and inhibiting heme oxygenase-1.
Wang C, He J, Jin H, Xiao H, Peng S, Xie J, Zhang L, Guo J
Chemosphere 2023 Nov;341:140087
Chemosphere 2023 Nov;341:140087
Propofol Pretreatment Inhibits Liver Damage in Mice with Hepatic Ischemia/Reperfusion Injury and Protects Human Hepatocyte in Hypoxia/Reoxygenation.
Li J, Wang R, Chen H, Yang Y, Yang X, Wang W
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2023 Nov;34(11):1171-1179
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2023 Nov;34(11):1171-1179
Pregnane X receptor (PXR) deficiency protects against spinal cord injury by activating NRF2/HO-1 pathway.
Xuan LN, Hu ZX, Jiang ZF, Zhang C, Sun XW, Ming WH, Liu HT, Qiao RF, Shen LJ, Liu SB, Wang GY, Wen L, Luan ZL, Yin J
CNS neuroscience & therapeutics 2023 Nov;29(11):3460-3478
CNS neuroscience & therapeutics 2023 Nov;29(11):3460-3478
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death.
Chen X, Chen J, Miao C, Yin G, Zhang Z, Sun R, Ni S
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage.
Yuan Z, Li J, Zou X, Liu C, Lu J, Ni C, Tang L, Wu X, Yan F
Journal of cellular and molecular medicine 2023 Nov;27(22):3465-3477
Journal of cellular and molecular medicine 2023 Nov;27(22):3465-3477
Cyclovirobuxine D alleviates aldosterone-induced myocardial hypertrophy by protecting mitochondrial function depending on the mutual regulation of Nrf2-SIRT3.
Wang X, Wu H, An J, Zhang G, Chen Y, Fu L, Tao L, Liang G, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115618
CDDO-Me ameliorates podocyte injury through anti-oxidative stress and regulation of actin cytoskeleton in adriamycin nephropathy.
Xu C, Liu X, Zhai X, Wang G, Qin W, Cheng Z, Chen Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115617
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115617
Koumine ameliorates neuroinflammation by regulating microglia polarization via activation of Nrf2/HO-1 pathway.
Wang L, Ding YY, Wu YQ, Zhao C, Wu J, Wang WJ, Meng FH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115608
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115608
Treatment of human cardiac fibroblasts with the protein arginine deiminase inhibitor BB-Cl-amidine activates the Nrf2/HO-1 signaling pathway.
Stachowicz A, Sadiq A, Walker B, Sundararaman N, Fert-Bober J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115443
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115443
The eNOS-induced leonurine's new role in improving the survival of random skin flap.
Chen T, Chen H, Fu Y, Liu X, Huang H, Li Z, Li S
International immunopharmacology 2023 Nov;124(Pt B):111037
International immunopharmacology 2023 Nov;124(Pt B):111037
A natural sesquiterpene lactone isolinderalactone attenuates lipopolysaccharide-induced inflammatory response and acute lung injury through inhibition of NF-κB pathway and activation Nrf2 pathway in macrophages.
Shen X, Chen H, Zhang H, Luo L, Wen T, Liu L, Hu Q, Wang L
International immunopharmacology 2023 Nov;124(Pt B):110965
International immunopharmacology 2023 Nov;124(Pt B):110965
Activation of Nrf2/ARE pathway by Anisodamine (654-2) for Inhibition of cellular aging and alleviation of Radiation-Induced lung injury.
Guo H, Chen J, Yu H, Dong L, Yu R, Li Q, Song J, Chen H, Zhang H, Pu J, Wang W
International immunopharmacology 2023 Nov;124(Pt A):110864
International immunopharmacology 2023 Nov;124(Pt A):110864
Glycosides of Buyang Huanwu decoction inhibits pyroptosis associated with cerebral ischemia-reperfusion through Nrf2-mediated antioxidant signaling pathway both in vivo and in vitro.
She Y, Shao L, Jiao K, Sun R, Lang T, Long H, Tang Y, Zhang W, Ding C, Deng C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155001
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Nov;120:155001
Wogonin inhibits oxidative stress and vascular calcification via modulation of heme oxygenase-1.
Lu L, Li Y, Dong Q, Fang J, Chen A, Lan Z, Ye Y, Yan J, Liang Q
European journal of pharmacology 2023 Nov 5;958:176070
European journal of pharmacology 2023 Nov 5;958:176070
Quercetin Attenuates the Combined Effects of Zearalenone and Lipopolysaccharide on IPEC-J2 Cell Injury through Activating the Nrf2 Signaling Pathway.
Wang C, Fu Y, Wang R, Wang Q, Yu H, Zhang J
Toxins 2023 Nov 30;15(12)
Toxins 2023 Nov 30;15(12)
Fucoidan Ameliorates Ferroptosis in Ischemia-reperfusion-induced Liver Injury through Nrf2/HO-1/GPX4 Activation.
Li JJ, Dai WQ, Mo WH, Xu WQ, Li YY, Guo CY, Xu XF
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Journal of clinical and translational hepatology 2023 Nov 28;11(6):1341-1354
Chlorogenic Acid Alleviated AFB1-Induced Hepatotoxicity by Regulating Mitochondrial Function, Activating Nrf2/HO-1, and Inhibiting Noncanonical NF-κB Signaling Pathway.
Wang Q, Liu T, Koci M, Wang Y, Fu Y, Ma M, Ma Q, Zhao L
Antioxidants (Basel, Switzerland) 2023 Nov 22;12(12)
Antioxidants (Basel, Switzerland) 2023 Nov 22;12(12)
Spermidine suppresses oxidative stress and ferroptosis by Nrf2/HO-1/GPX4 and Akt/FHC/ACSL4 pathway to alleviate ovarian damage.
Niu C, Jiang D, Guo Y, Wang Z, Sun Q, Wang X, Ling W, An X, Ji C, Li S, Zhao H, Kang B
Life sciences 2023 Nov 1;332:122109
Life sciences 2023 Nov 1;332:122109
MAGL inhibition relieves synovial inflammation and pain via regulating NOX4-Nrf2 redox balance in osteoarthritis.
Li X, Tao H, Zhou J, Zhang L, Shi Y, Zhang C, Sun W, Chu M, Chen K, Gu C, Yang X, Geng D, Hao Y
Free radical biology & medicine 2023 Nov 1;208:13-25
Free radical biology & medicine 2023 Nov 1;208:13-25
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Xi Y, Chi Z, Tao X, Zhai X, Zhao Z, Ren J, Yang S, Dong D
Environmental toxicology 2023 May;38(5):1153-1161
Environmental toxicology 2023 May;38(5):1153-1161
Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration.
Zhu J, Sun R, Yan C, Sun K, Gao L, Zheng B, Shi J
Cell cycle (Georgetown, Tex.) 2023 May;22(10):1196-1214
Cell cycle (Georgetown, Tex.) 2023 May;22(10):1196-1214
Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice.
Liu Y, Mi Y, Wang Y, Meng Q, Xu L, Liu Y, Zhou D, Wang Y, Liang D, Li W, Li N, Hou Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154729
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154729
Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of mastitis.
Shao D, Shen W, Miao Y, Gao Z, Pan M, Wei Q, Yan Z, Zhao X, Ma B
Journal of animal science and biotechnology 2023 May 3;14(1):61
Journal of animal science and biotechnology 2023 May 3;14(1):61
Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway.
Zhang X, Wang S, Jin Y, Wang J, Wang R, Yang X, Zhang S, Yan T, Jia Y
Journal of ethnopharmacology 2023 May 23;308:116253
Journal of ethnopharmacology 2023 May 23;308:116253
Cardamonin targets KEAP1/NRF2 signaling for protection against atherosclerosis.
Fan P, Meng H, Hao W, Zheng Y, Li H, Zhang Z, Du L, Guo X, Wang D, Wang Y, Wu H
Food & function 2023 May 22;14(10):4905-4920
Food & function 2023 May 22;14(10):4905-4920
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.
Li C, Zhang X, Li J, Liang L, Zeng J, Wen M, Pan L, Lv D, Liu M, Cheng Y, Huang H
European journal of pharmacology 2023 May 15;947:175676
European journal of pharmacology 2023 May 15;947:175676
ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer.
Ji J, Ma S, Zhu Y, Zhao J, Tong Y, You Q, Jiang Z
Journal of medicinal chemistry 2023 May 11;66(9):6070-6081
Journal of medicinal chemistry 2023 May 11;66(9):6070-6081
β-Hydroxybutyric acid upregulated by Suhuang antitussive capsule ameliorates cough variant asthma through GSK3β/AMPK-Nrf2 signal axis.
Jiang H, Bai Z, Ou Y, Liu H, Si Z, Liu Y, Liu X, Liu X, Zhang Z, Tan N
Journal of ethnopharmacology 2023 May 10;307:116013
Journal of ethnopharmacology 2023 May 10;307:116013
Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization.
Shu N, Zhang Z, Wang X, Li R, Li W, Liu X, Zhang Q, Jiang Z, Tao L, Zhang L, Hou S
Investigative ophthalmology & visual science 2023 May 1;64(5):21
Investigative ophthalmology & visual science 2023 May 1;64(5):21
The role of ferroptosis mediated by Bmal1/Nrf2 in nicotine -induce injury of BTB integrity.
Zhang Z, Cheng J, Yang L, Li X, Hua R, Xu D, Jiang Z, Li Q
Free radical biology & medicine 2023 May 1;200:26-35
Free radical biology & medicine 2023 May 1;200:26-35
Liquiritin alleviates alpha-naphthylisothiocyanate-induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway.
Yan M, Guo L, Ma J, Yang Y, Tang T, Zhang B, Zhou W, Zou W, Hou Z, Gu H, Gong H
Journal of applied toxicology : JAT 2023 Mar;43(3):350-359
Journal of applied toxicology : JAT 2023 Mar;43(3):350-359
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Wang X, Tan Y, Liu F, Wang J, Liu F, Zhang Q, Li J
Journal of orthopaedic translation 2023 Mar;39:135-146
Journal of orthopaedic translation 2023 Mar;39:135-146
Bisphenol S induces oxidative stress-mediated impairment of testosterone synthesis by inhibiting the Nrf2/HO-1 signaling pathway.
Wang YX, Dai W, Li YZ, Wu ZY, Kan YQ, Zeng HC, He QZ
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Journal of biochemical and molecular toxicology 2023 Mar;37(3):e23273
Ro25-6981 alleviates neuronal damage and improves cognitive deficits by attenuating oxidative stress via the Nrf2/ARE pathway in ischemia/reperfusion rats.
Gao X, Chen F, Xu X, Liu J, Dong F, Liu Y
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Mar;32(3):106971
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2023 Mar;32(3):106971
Protective effects of baicalin against L-glutamate-induced oxidative damage in HT-22 cells by inhibiting NLRP3 inflammasome activation via Nrf2/HO-1 signaling.
Li J, Wang G, Zhang Y, Fan X, Yao M
Iranian journal of basic medical sciences 2023 Mar;26(3):351-358
Iranian journal of basic medical sciences 2023 Mar;26(3):351-358
LncRNA UCA1 promoted cisplatin resistance in lung adenocarcinoma with HO1 targets NRF2/HO1 pathway.
Shi W, Ling L, Li C, Wu R, Zhang M, Shao F, Wang Y
Journal of cancer research and clinical oncology 2023 Mar;149(3):1295-1311
Journal of cancer research and clinical oncology 2023 Mar;149(3):1295-1311
Neuroprotective effect of a Keap1-Nrf2 Protein-Protein Inter-action inhibitor on cerebral Ischemia/Reperfusion injury.
Qi Z, Tong Y, Luo H, Chen M, Zhou N, Chen L
Bioorganic chemistry 2023 Mar;132:106350
Bioorganic chemistry 2023 Mar;132:106350
Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss.
Guo J, Ren R, Guo Z, Sun K, He J, Shao J, Wang X
International immunopharmacology 2023 Mar;116:109820
International immunopharmacology 2023 Mar;116:109820
FGF4 improves hepatocytes ferroptosis in autoimmune hepatitis mice via activation of CISD3.
Jiang H, Fang Y, Wang Y, Li T, Lin H, Lin J, Pan T, Liu Q, Lv J, Chen D, Chen Y
International immunopharmacology 2023 Mar;116:109762
International immunopharmacology 2023 Mar;116:109762
Stimulation of Nuclear Factor (Erythroid-Derived 2)-like 2 Signaling by Nucleus Targeted Irradiation with Proton Microbeam.
Wang J, Oikawa M, Konishi T
Biology 2023 Mar 9;12(3)
Biology 2023 Mar 9;12(3)
NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer.
Weiss-Sadan T, Ge M, Hayashi M, Gohar M, Yao CH, de Groot A, Harry S, Carlin A, Fischer H, Shi L, Wei TY, Adelmann CH, Wolf K, Vornbäumen T, Dürr BR, Takahashi M, Richter M, Zhang J, Yang TY, Vijay V, Fisher DE, Hata AN, Haigis MC, Mostoslavsky R, Bardeesy N, Papagiannakopoulos T, Bar-Peled L
Cell metabolism 2023 Mar 7;35(3):487-503.e7
Cell metabolism 2023 Mar 7;35(3):487-503.e7
Uridine Alleviates Sepsis-Induced Acute Lung Injury by Inhibiting Ferroptosis of Macrophage.
Lai K, Song C, Gao M, Deng Y, Lu Z, Li N, Geng Q
International journal of molecular sciences 2023 Mar 7;24(6)
International journal of molecular sciences 2023 Mar 7;24(6)
Antialcohol and Hepatoprotective Effects of Tamarind Shell Extract on Ethanol-Induced Damage to HepG2 Cells and Animal Models.
Han SC, Huang RP, Zhang QY, Yan CY, Li XY, Li YF, He RR, Li WX
Foods (Basel, Switzerland) 2023 Mar 3;12(5)
Foods (Basel, Switzerland) 2023 Mar 3;12(5)
Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway.
Tian Y, Che H, Yang J, Jin Y, Yu H, Wang C, Fu Y, Li N, Zhang J
Toxins 2023 Mar 21;15(3)
Toxins 2023 Mar 21;15(3)
Reduced SUMOylation of Nrf2 signaling contributes to its inhibition induced by amyloid-β.
Wang P, Wang X, Qiao K, Zhang Y, Nie Q, Cui J, Sun J, Li L
Neuroscience letters 2023 Mar 16;799:137118
Neuroscience letters 2023 Mar 16;799:137118
Elevation of HO-1 expression protects the intestinal mucosal barrier in severe acute pancreatitis via inhibition of the MLCK/p-MLC signaling pathway.
Zhang J, Jiang Y, Li H, Wang J, Li C, Zhang D
Experimental cell research 2023 Mar 15;424(2):113508
Experimental cell research 2023 Mar 15;424(2):113508
1,2,4,5-Tetrazine-tethered probes for fluorogenically imaging superoxide in live cells with ultrahigh specificity.
Jiang X, Li M, Wang Y, Wang C, Wang Y, Shen T, Shen L, Liu X, Wang Y, Li X
Nature communications 2023 Mar 14;14(1):1401
Nature communications 2023 Mar 14;14(1):1401
Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes.
Yang X, Dong S, Li C, Li M, Xing C, He J, Peng C, Shao H, Jia Q
Toxicology letters 2023 Mar 1;376:39-50
Toxicology letters 2023 Mar 1;376:39-50
Effects and mechanisms of Xiaochaihu Tang against liver fibrosis: An integration of network pharmacology, molecular docking and experimental validation.
Wang SJ, Ye W, Li WY, Tian W, Zhang M, Sun Y, Feng YD, Liu CX, Liu SY, Cao W, Meng JR, Li XQ
Journal of ethnopharmacology 2023 Mar 1;303:116053
Journal of ethnopharmacology 2023 Mar 1;303:116053
Tingli Dazao Decoction pretreatment ameliorates mitochondrial damage induced by oxidative stress in cardiomyocytes.
Chen H, Zhu Y, Zhao X, Yang Z
Journal of ethnopharmacology 2023 Mar 1;303:115987
Journal of ethnopharmacology 2023 Mar 1;303:115987
Buyang Huanwu decoction alleviates oxidative injury of cerebral ischemia-reperfusion through PKCε/Nrf2 signaling pathway.
Yin M, Liu Z, Wang J, Gao W
Journal of ethnopharmacology 2023 Mar 1;303:115953
Journal of ethnopharmacology 2023 Mar 1;303:115953
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Liu X, Xi H, Han S, Zhang H, Hu J
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Remote preconditioning combined with nebulized budesonide alleviate lipopolysaccharide induced acute lung injury via regulating HO-1 and NF-κB in rats.
Zhao L, Chen Z, Cheng J, Chen B, Liu Y
Pulmonary pharmacology & therapeutics 2023 Jun;80:102215
Pulmonary pharmacology & therapeutics 2023 Jun;80:102215
Farnesol Exerts Protective Effects against Chronic Sleep Deprivation-Induced Cognitive Impairment via Activation SIRT1/Nrf2 Pathway in the Hippocampi of Adult Mice.
Li Y, Xie Z, Luo X, Wang X, Wang Y, Guo M, Zhou Z, Sun R, Hua D, Luo A, Li S
Molecular nutrition & food research 2023 Jun;67(11):e2200735
Molecular nutrition & food research 2023 Jun;67(11):e2200735
Rutin Attenuates Oxidative Stress Via PHB2-Mediated Mitophagy in MPP(+)-Induced SH-SY5Y Cells.
Lai X, Zhang Y, Wu J, Shen M, Yin S, Yan J
Neurotoxicity research 2023 Jun;41(3):242-255
Neurotoxicity research 2023 Jun;41(3):242-255
BACH1 promotes intervertebral disc degeneration by regulating HMOX1/GPX4 to mediate oxidative stress, ferroptosis, and lipid metabolism in nucleus pulposus cells.
Yao B, Cai Y, Wan L, Deng J, Zhao L, Wang W, Han Z
The journal of gene medicine 2023 Jun;25(6):e3488
The journal of gene medicine 2023 Jun;25(6):e3488
Effect of PPARγ on oxidative stress in diabetes-related dry eye.
Wang J, Chen S, Zhao X, Guo Q, Yang R, Zhang C, Huang Y, Ma L, Zhao S
Experimental eye research 2023 Jun;231:109498
Experimental eye research 2023 Jun;231:109498
BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion.
Guo K, Shang Y, Wang Z, Li Y, Chen J, Zhu B, Zhang D, Chen J
International immunopharmacology 2023 Jun;119:110201
International immunopharmacology 2023 Jun;119:110201
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.
Yan B, Mao X, Hu S, Wang S, Liu X, Sun J
International immunopharmacology 2023 Jun;119:110166
International immunopharmacology 2023 Jun;119:110166
Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling.
Wang H, Jia X, Zhang M, Cheng C, Liang X, Wang X, Xie F, Wang J, Yu Y, He Y, Dong Q, Wang Y, Xu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154786
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154786
Wenqingyin suppresses ferroptosis in the pathogenesis of sepsis-induced liver injury by activating the Nrf2-mediated signaling pathway.
Xie L, Zhou C, Wu Y, Fu X, Zhang G, Han X, Xie S, Chen G, Xu H, Deng B, Liu B, Zhou Y, Li A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154748
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154748
PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis.
Wang Z, Li R, Hou N, Zhang J, Wang T, Fan P, Ji C, Zhang B, Liu L, Wang Y, Kong J, Yao Q, Duan J, Zhao G, Ling R, Zhang J
Journal for immunotherapy of cancer 2023 Jun;11(6)
Journal for immunotherapy of cancer 2023 Jun;11(6)
Ferulic Acid Alleviates Hepatic Lipid Accumulation and Inflammation by Improving Proximal and Distal Intestinal Barriers in NAFLD Mice.
Fu J, Yang J, He L, Yang C, He J, Hua Y, Guo J, Liu S
The Tohoku journal of experimental medicine 2023 Jun 7;260(2):149-163
The Tohoku journal of experimental medicine 2023 Jun 7;260(2):149-163
Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals.
Kenny TC, Khan A, Son Y, Yue L, Heissel S, Sharma A, Pasolli HA, Liu Y, Gamazon ER, Alwaseem H, Hite RK, Birsoy K
Cell metabolism 2023 Jun 6;35(6):1057-1071.e12
Cell metabolism 2023 Jun 6;35(6):1057-1071.e12
Antioxidant Peptides from Monkfish Swim Bladders: Ameliorating NAFLD In Vitro by Suppressing Lipid Accumulation and Oxidative Stress via Regulating AMPK/Nrf2 Pathway.
Wu MF, Xi QH, Sheng Y, Wang YM, Wang WY, Chi CF, Wang B
Marine drugs 2023 Jun 16;21(6)
Marine drugs 2023 Jun 16;21(6)
Long-term effect of PBDE-99 prenatal exposure on spermatogenic injuries via the dysregulation of autophagy.
Wu J, Deng F, Tang X, Chen W, Zhou R, Zhao T, Mao X, Shu F
Journal of hazardous materials 2023 Jun 15;452:131234
Journal of hazardous materials 2023 Jun 15;452:131234
Rapamycin Inhibits Osteoclastogenesis and Prevents LPS-Induced Alveolar Bone Loss by Oxidative Stress Suppression.
Feng C, Liu Y, Zhang BY, Zhang H, Shan FY, Li TQ, Zhao ZN, Wang XX, Zhang XY
ACS omega 2023 Jun 13;8(23):20739-20754
ACS omega 2023 Jun 13;8(23):20739-20754
CaMKK2 alleviates myocardial ischemia/reperfusion injury by inhibiting oxidative stress and inflammation via the action on the AMPK-AKT-GSK-3β/Nrf2 signaling cascade.
Li C, Hao J, Qiu H, Xin H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Jul;72(7):1409-1425
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
Liang C, Yi K, Zhou X, Li X, Zhong C, Cao H, Xie C, Zhu J
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
Resveratrol Promotes Gluconeogenesis by Inhibiting SESN2-mTORC2-AKT Pathway in Calf Hepatocytes.
Wang G, Qin S, Geng H, Zheng Y, Li R, Xia C, Chen L, Yao J, Deng L
The Journal of nutrition 2023 Jul;153(7):1930-1943
The Journal of nutrition 2023 Jul;153(7):1930-1943
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Li X, Yu X, He S, Li J
International immunopharmacology 2023 Jul;120:110404
International immunopharmacology 2023 Jul;120:110404
Glycyrrhizin protects against particulate matter-induced lung injury via regulation of endoplasmic reticulum stress and NLRP3 inflammasome-mediated pyroptosis through Nrf2/HO-1/NQO1 signaling pathway.
Shi Q, Qian Y, Wang B, Liu L, Chen Y, Chen C, Feng L, Chen J, Dong N
International immunopharmacology 2023 Jul;120:110371
International immunopharmacology 2023 Jul;120:110371
Metformin Ameliorates 2.856 GHz Microwave- Radiation-Induced Reproductive Impairments in Male Rats via Inhibition of Oxidative Stress and Apoptosis.
Men J, Zhang L, Peng R, Li Y, Li M, Wang H, Zhao L, Zhang J, Wang H, Xu X, Dong J, Wang J, Yao B, Guo J
International journal of molecular sciences 2023 Jul 31;24(15)
International journal of molecular sciences 2023 Jul 31;24(15)
Sulforaphane protects microvascular endothelial cells in lower limb ischemia/reperfusion injury mice.
Chen F, Zhan J, Al Mamun A, Tao Y, Huang S, Zhao J, Zhang Y, Xu Y, Du S, Lu W, Li X, Chen Z, Xiao J
Food & function 2023 Jul 31;14(15):7176-7194
Food & function 2023 Jul 31;14(15):7176-7194
Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice.
Pei Z, Zhou R, Yao W, Dong S, Liu Y, Gao Z
iScience 2023 Jul 21;26(7):107080
iScience 2023 Jul 21;26(7):107080
The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing.
Li T, Yang C, Cao H, Mo S, Li B, Huang Z, Zhang R, Wu J, Zhang K, Gao Y
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Molecules (Basel, Switzerland) 2023 Jul 19;28(14)
Discovery of NAFLD-Improving Agents by Promoting the Degradation of Keap1.
Qi M, Zhong H, Cheng Z, Chen S, Xiao H, Shang J, Chen L, Sun J
Journal of medicinal chemistry 2023 Jul 13;66(13):9184-9200
Journal of medicinal chemistry 2023 Jul 13;66(13):9184-9200
Tripterygium glycosides reverse chemotherapy resistance in ovarian cancer by targeting the NRF2/GPX4 signal axis to induce ferroptosis of drug-resistant human epithelial ovarian cancer cells.
Ma B, Zhong Y, Chen R, Zhan X, Huang G, Xiong Y, Tan B
Biochemical and biophysical research communications 2023 Jul 12;665:178-186
Biochemical and biophysical research communications 2023 Jul 12;665:178-186
Andrographolide induced ferroptosis in multiple myeloma cells by regulating the P38/Nrf2/HO-1 pathway.
Li W, Fu H, Fang L, Chai H, Ding B, Qian S
Archives of biochemistry and biophysics 2023 Jul 1;742:109622
Archives of biochemistry and biophysics 2023 Jul 1;742:109622
Antibiotics administration alleviates the high fat diet-induced obesity through altering the lipid metabolism in young mice.
Luo S, Zhang H, Jiang X, Xia Y, Tang S, Duan X, Sun W, Gao M, Chen C, Zou Z, Zhou L, Qiu J
Lipids 2023 Jan;58(1):19-32
Lipids 2023 Jan;58(1):19-32
HMOX1 Promotes Ferroptosis Induced by Erastin in Lens Epithelial Cell through Modulates Fe(2+) Production.
Liao S, Huang M, Liao Y, Yuan C
Current eye research 2023 Jan;48(1):25-33
Current eye research 2023 Jan;48(1):25-33
iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation.
Guo Y, Wen J, He A, Qu C, Peng Y, Luo S, Wang X
Journal of advanced research 2023 Jan;43:175-186
Journal of advanced research 2023 Jan;43:175-186
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487
Phytochemistry 2023 Jan;205:113487
Novel function of Roxadustat (FG-4592) as an anti-shock drug in sepsis by regulating mitochondrial oxidative stress and energy metabolism.
Long G, Pei Z, Wu M, Wei K, Du Y, Wang Q, Zhang Y, Huang S, Chen H, Xia W, Jia Z
Biochimica et biophysica acta. General subjects 2023 Jan;1867(1):130264
Biochimica et biophysica acta. General subjects 2023 Jan;1867(1):130264
Pine pollen extract alleviates ethanol-induced oxidative stress and apoptosis in HepG2 cells via MAPK signaling.
Ma D, Wang Z, He Z, Wang Z, Chen Q, Qin F, Zeng M, Chen J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113550
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113550
Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice.
Yu H, Peng Y, Dong W, Shen B, Yang G, Nie Q, Tian Y, Qin L, Song C, Chen B, Zhao Y, Li L, Hong S
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219488
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219488
N-acetylglucosamine-bearing polymers mimicking O-GlcNAc-modified proteins elicit anti-fibrotic activities in myofibroblasts and activated stellate cells.
Ise H, Araki Y, Song I, Akatsuka G
Glycobiology 2023 Jan 8;33(1):17-37
Glycobiology 2023 Jan 8;33(1):17-37
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
Shao D, Gao Z, Zhao Y, Fan M, Zhao X, Wei Q, Pan M, Ma B
International journal of molecular sciences 2023 Jan 5;24(2)
International journal of molecular sciences 2023 Jan 5;24(2)
Paricalcitol Ameliorates Acute Kidney Injury in Mice by Suppressing Oxidative Stress and Inflammation via Nrf2/HO-1 Signaling.
Wang S, Huang S, Liu X, He Y, Liu Y
International journal of molecular sciences 2023 Jan 4;24(2)
International journal of molecular sciences 2023 Jan 4;24(2)
Qi Gong Wan ameliorates adipocyte hypertrophy and inflammation in adipose tissue in a PCOS mouse model through the Nrf2/HO-1/Cyp1b1 pathway: Integrating network pharmacology and experimental validation in vivo.
Zheng R, Shen H, Li J, Zhao J, Lu L, Hu M, Lin Z, Ma H, Tan H, Hu M, Li J
Journal of ethnopharmacology 2023 Jan 30;301:115824
Journal of ethnopharmacology 2023 Jan 30;301:115824
Protective effects of Lycium barbarum L. berry extracts against oxidative stress-induced damage of the retina of aging mouse and ARPE-19 cells.
Zheng HL, Li MT, Zhou T, Wang YY, Shang EX, Hua YQ, Duan JA, Zhu Y
Food & function 2023 Jan 3;14(1):399-412
Food & function 2023 Jan 3;14(1):399-412
Protein kinase D1 promotes the survival of random-pattern skin flaps in rats.
Chen J, Chen H, Muhammad I, Han T, Zhang D, Li B, Zhou X, Zhou F
Biochemical and biophysical research communications 2023 Jan 22;641:67-76
Biochemical and biophysical research communications 2023 Jan 22;641:67-76
Inhibition of cGAS ameliorates acute lung injury triggered by zinc oxide nanoparticles.
Jiang Z, Jiang Y, Fan J, Zhang J, Xu G, Fan Y, Zhang L, Qin X, Jiang X, Mao L, Liu G, Chen C, Zou Z
Toxicology letters 2023 Jan 15;373:62-75
Toxicology letters 2023 Jan 15;373:62-75
Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway.
Wang F, Zhan Y, Li M, Wang L, Zheng A, Liu C, Wang H, Wang T
ACS pharmacology & translational science 2023 Jan 13;6(1):76-87
ACS pharmacology & translational science 2023 Jan 13;6(1):76-87
Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling.
Chen Y, Zhou C, Bian Y, Fu F, Zhu B, Zhao X, Zhang M, Zhou C, Yao S, Zhang Z, Luo H, Ge Y, Wu C, Ruan H
Ecotoxicology and environmental safety 2023 Jan 1;249:114376
Ecotoxicology and environmental safety 2023 Jan 1;249:114376
Organic extracts in PM2.5 are the major triggers to induce ferroptosis in SH-SY5Y cells.
Guo C, Lyu Y, Xia S, Ren X, Li Z, Tian F, Zheng J
Ecotoxicology and environmental safety 2023 Jan 1;249:114350
Ecotoxicology and environmental safety 2023 Jan 1;249:114350
Inhibition of YAP by lenvatinib in endothelial cells increases blood pressure through ferroptosis.
Liang C, Zhu D, Xia W, Hong Z, Wang QS, Sun Y, Yang YC, Han SQ, Tang LL, Lou J, Wu MM, Zhang ZR
Biochimica et biophysica acta. Molecular basis of disease 2023 Jan 1;1869(1):166586
Biochimica et biophysica acta. Molecular basis of disease 2023 Jan 1;1869(1):166586
Disruption of the lung-gut-brain axis is responsible for cortex damage induced by pulmonary exposure to zinc oxide nanoparticles.
Zhang L, Zhang Y, Jiang X, Mao L, Xia Y, Fan Y, Li N, Jiang Z, Qin X, Jiang Y, Liu G, Qiu F, Zhang J, Zou Z, Chen C
Toxicology 2023 Feb;485:153390
Toxicology 2023 Feb;485:153390
Dual Antioxidant DH-217 Mitigated Cerebral Ischemia-Reperfusion Injury by Targeting IKKβ/Nrf2/HO-1 Signal Axis.
Shen M, Zheng Y, Li G, Chen Y, Huang L, Wu J, Hong C
Neurochemical research 2023 Feb;48(2):579-590
Neurochemical research 2023 Feb;48(2):579-590
Berberine promotes the viability of random skin flaps via the PI3K/Akt/eNOS signaling pathway.
Chen J, Jiang Z, Liu X, Wang K, Fan W, Chen T, Li Z, Lin D
Phytotherapy research : PTR 2023 Feb;37(2):424-437
Phytotherapy research : PTR 2023 Feb;37(2):424-437
Pharmacological vitamin C inhibits mTOR signaling and tumor growth by degrading Rictor and inducing HMOX1 expression.
Qin S, Wang G, Chen L, Geng H, Zheng Y, Xia C, Wu S, Yao J, Deng L
PLoS genetics 2023 Feb;19(2):e1010629
PLoS genetics 2023 Feb;19(2):e1010629
Chemical constituents from the stems and leaves of Amomum villosum Lour. and their anti-inflammatory and antioxidant activities.
Gao C, Zhu M, Xu W, Wang Y, Xiong L, Sun D, Sun M, Lin Y, Li H, Chen L
Bioorganic chemistry 2023 Feb;131:106281
Bioorganic chemistry 2023 Feb;131:106281
α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson's disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway.
Huang B, Hu G, Zong X, Yang S, He D, Gao X, Liu D
International immunopharmacology 2023 Feb;115:109698
International immunopharmacology 2023 Feb;115:109698
Iso-seco-tanapartholide induces p62 covalent oligomerization to activate KEAP1-NRF2 redox pathway in rheumatoid arthritis.
Zhu D, Kong M, Chen C, Luo J, Kong L
International immunopharmacology 2023 Feb;115:109689
International immunopharmacology 2023 Feb;115:109689
Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.
Gong MJ, Zhang HB, Lou M, Wang YS, Ma RP, Hu ZZ, Zheng GX, Zhang Y
Immunity, inflammation and disease 2023 Feb;11(2):e788
Immunity, inflammation and disease 2023 Feb;11(2):e788
Active Nrf2 signaling flexibly regulates HO-1 and NQO-1 in hypoxic Gansu Zokor (Eospalax cansus).
Li M, Peng Y, Chen W, Gao Y, Yang M, Li J, He J
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110811
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110811
Non-Lethal Concentrations of CdCl(2) Cause Marked Alternations in Cellular Stress Responses within Exposed Sertoli Cell Line.
Man Y, Liu Y, Xiong C, Zhang Y, Zhang L
Toxics 2023 Feb 9;11(2)
Toxics 2023 Feb 9;11(2)
Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function.
Lei I, Huang W, Noly PE, Naik S, Ghali M, Liu L, Pagani FD, Abou El Ela A, Pober JS, Pitt B, Platt JL, Cascalho M, Wang Z, Chen YE, Mortensen RM, Tang PC
Science translational medicine 2023 Feb 8;15(682):eade3782
Science translational medicine 2023 Feb 8;15(682):eade3782
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Chen Y, Liu X, Li L, He X, Zheng F, Zhang Y, Gao H, Jin Z, Wu D, Wang Q, Tao H, Zhao Y, Liu W, Zou L
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Cdh5-mediated Fpn1 deletion exerts neuroprotective effects during the acute phase and inhibitory effects during the recovery phase of ischemic stroke.
Zheng H, Guo X, Kang S, Li Z, Tian T, Li J, Wang F, Yu P, Chang S, Chang YZ
Cell death & disease 2023 Feb 25;14(2):161
Cell death & disease 2023 Feb 25;14(2):161
Lactobacillus johnsonii L531 Ameliorates Salmonella enterica Serovar Typhimurium Diarrhea by Modulating Iron Homeostasis and Oxidative Stress via the IRP2 Pathway.
Chen K, Wang J, Guo L, Wang J, Yang L, Hu T, Zhao Y, Wang X, Zhu Y
Nutrients 2023 Feb 23;15(5)
Nutrients 2023 Feb 23;15(5)
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Wang Y, Liu Q, Chu C, Li L, Wang Z, Liu Q, Wu G, Wei X, An L, Ma J
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Astaxanthin Promotes the Survival of Adipose-Derived Stem Cells by Alleviating Oxidative Stress via Activating the Nrf2 Signaling Pathway.
Yang CS, Guo XS, Yue YY, Wang Y, Jin XL
International journal of molecular sciences 2023 Feb 14;24(4)
International journal of molecular sciences 2023 Feb 14;24(4)
Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.
Fei Q, Liu J, Qiao L, Zhang M, Xia H, Lu D, Wu D, Wang J, Li R, Li J, Yang F, Liu D, Xie B, Hui W, Qian B
Biochemical and biophysical research communications 2023 Feb 12;644:140-148
Biochemical and biophysical research communications 2023 Feb 12;644:140-148
Otoprotective Effects of Fucoidan Reduce Cisplatin-Induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells.
Hsieh CY, Lin JN, Kang TY, Wen YH, Yu SH, Wu CC, Wu HP
International journal of molecular sciences 2023 Feb 10;24(4)
International journal of molecular sciences 2023 Feb 10;24(4)
A novel combination therapy with Cabozantinib and Honokiol effectively inhibits c-Met-Nrf2-induced renal tumor growth through increased oxidative stress.
Rawat L, Balan M, Sasamoto Y, Sabarwal A, Pal S
Redox biology 2023 Dec;68:102945
Redox biology 2023 Dec;68:102945
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Wang Z, Li L, Chu C, Wei X, Liu Q, Wang R, Zhang G, Wu G, Wang Y, An L, Li X
International journal of oncology 2023 Dec;63(6)
International journal of oncology 2023 Dec;63(6)
Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.
Ding J, Lu B, Liu L, Zhong Z, Wang N, Li B, Sheng W, He Q
Pharmaceutical biology 2023 Dec;61(1):213-227
Pharmaceutical biology 2023 Dec;61(1):213-227
Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways.
Li J, Yu J, Guo J, Liu J, Wan G, Wei X, Yang X, Shi J
Pharmaceutical biology 2023 Dec;61(1):1175-1185
Pharmaceutical biology 2023 Dec;61(1):1175-1185
PM(2.5) exposure increases dry eye disease risks through corneal epithelial inflammation and mitochondrial dysfunctions.
Yu D, Cai W, Shen T, Wu Y, Ren C, Li T, Hu C, Zhu M, Yu J
Cell biology and toxicology 2023 Dec;39(6):2615-2630
Cell biology and toxicology 2023 Dec;39(6):2615-2630
Licochalcone B confers protective effects against LPS-Induced acute lung injury in cells and mice through the Keap1/Nrf2 pathway.
Huang J, Zhu Y, Li S, Jiang H, Chen N, Xiao H, Liu J, Liang D, Zheng Q, Tang J, Meng X
Redox report : communications in free radical research 2023 Dec;28(1):2243423
Redox report : communications in free radical research 2023 Dec;28(1):2243423
Park7 protects retinal ganglion cells and promotes functional preservation after optic nerve crush via regulation of the Nrf2 signaling pathway.
Ouyang L, He T, Xing Y
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2023 Dec;261(12):3489-3502
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 2023 Dec;261(12):3489-3502
Xanthohumol attenuates renal ischemia/reperfusion injury by inhibiting ferroptosis.
Tang Z, Feng Y, Nie W, Li C
Experimental and therapeutic medicine 2023 Dec;26(6):571
Experimental and therapeutic medicine 2023 Dec;26(6):571
Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2.
Wang H, Yang G, Zhang X, Zhang H, Liu Y, Wang C, Miao L, Li Y, Huang Y, Teng H, Wang S, Cheng H, Zeng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Dec;182:114196
Astragaloside IV inhibits AOM/DSS-induced colitis-associated tumorigenesis via activation of PPARγ signaling in mice.
Liang J, Yang C, Li P, Zhang M, Xie X, Xie X, Chen Y, Wang Q, Zhou L, Luo X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155116
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155116
Protective effect of ethyl ferulate against hypoxic injury in retinal cells and retinal neovascularization in an oxygen-induced retinopathy model.
Xue R, Fan XL, Yang Q, Yu C, Lu TY, Wan GM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155097
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155097
7,8,3'-Trihydroxyflavone prevents doxorubicin-induced cardiotoxicity and mitochondrial dysfunction via activating Akt signaling pathway in H9c2 cells.
Zhao J, Yu HQ, Ge FQ, Zhang MR, Song YC, Guo DD, Li QH, Zhu H, Hang PZ
Cellular signalling 2023 Dec;112:110924
Cellular signalling 2023 Dec;112:110924
Probiotic-fermented Qushi decoction alleviates reserpine-induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis.
Zeng W, Chen Y, Zhang H, Peng L, Li Y, Liu B, Liang H, Du B, Li P
Journal of the science of food and agriculture 2023 Dec;103(15):7702-7711
Journal of the science of food and agriculture 2023 Dec;103(15):7702-7711
The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.
Zou L, Huang J, Zhang Q, Mo H, Xia W, Zhu C, Rao M
Human reproduction (Oxford, England) 2023 Dec 4;38(12):2422-2432
Human reproduction (Oxford, England) 2023 Dec 4;38(12):2422-2432
Dexmedetomidine alleviates ferroptosis following hepatic ischemia-reperfusion injury by upregulating Nrf2/GPx4-dependent antioxidant responses.
Zhang Y, Wei H, Wang M, Yu Y, Gu M, Zhong H, Dong S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115915
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115915
Tetrahydropalmatine: Orchestrating survival - Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps.
Chen X, Fu K, Lai Y, Dong C, Chen Z, Huang Y, Li G, Jiang R, Wu H, Wang A, Huang S, Shen L, Gao W, Li S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115887
Dietary pyrroloquinoline quinone improvement of the antioxidant capacity of laying hens and eggs are linked to the alteration of Nrf2/HO-1 pathway and gut microbiota.
Shao D, Liu L, Tong H, Shi S
Food chemistry: X 2023 Dec 30;20:101021
Food chemistry: X 2023 Dec 30;20:101021
Hepatotoxicity of the Pesticide Avermectin Exposure to Freshwater-Farmed Carp: Evidence from In Vivo and In Vitro Research.
Xin Y, Zhang T, Zhou M, Li X, Ping K, Ji X, Yang H, Dong J
Journal of agricultural and food chemistry 2023 Dec 27;71(51):20654-20670
Journal of agricultural and food chemistry 2023 Dec 27;71(51):20654-20670
Endometrial stromal cell autophagy-dependent ferroptosis caused by iron overload in ovarian endometriosis is inhibited by the ATF4-xCT pathway.
Dong X, Xu L, Wang S, Jiao X, Yan S, Huang Y, Yuan M, Wang G
Molecular human reproduction 2023 Dec 24;30(1)
Molecular human reproduction 2023 Dec 24;30(1)
Adoptive transfer of immature dendritic cells with high HO-1 expression delays the onset of T1DM in NOD mice.
Yang X, Ma Z, Tan X, Shi Y, Yuan M, Chen G, Luo X, Hou L
Life sciences 2023 Dec 15;335:122273
Life sciences 2023 Dec 15;335:122273
Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms.
Yang Y, Liu Z, Wu J, Bao S, Wang Y, Li J, Song T, Sun Y, Pi J
Antioxidants (Basel, Switzerland) 2023 Dec 10;12(12)
Antioxidants (Basel, Switzerland) 2023 Dec 10;12(12)
Mechanism of non-steroidal anti-androgen-induced liver injury: Reactive metabolites of flutamide and bicalutamide activate inflammasomes.
Kato R, Yamada T, Noda T, Tanaka S, Kohda Y, Ijiri Y
Toxicology in vitro : an international journal published in association with BIBRA 2023 Aug;90:105606
Toxicology in vitro : an international journal published in association with BIBRA 2023 Aug;90:105606
Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways.
Zhou Q, Zhou Q, Xia R, Zhang P, Xie Y, Yang Z, Khan A, Zhou Z, Tan W, Liu L
Heliyon 2023 Aug;9(8):e18746
Heliyon 2023 Aug;9(8):e18746
5-Methoxytryptophan ameliorates endotoxin-induced acute lung injury in vivo and in vitro by inhibiting NLRP3 inflammasome-mediated pyroptosis through the Nrf2/HO-1 signaling pathway.
Ma Y, Wang Z, Wu X, Ma Z, Shi J, He S, Li S, Li X, Li X, Li Y, Yu J
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Aug;72(8):1633-1647
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Aug;72(8):1633-1647
α-Lactalbumin Peptide Asp-Gln-Trp Ameliorates Hepatic Steatosis and Oxidative Stress in Free Fatty Acids-Treated HepG2 Cells and High-Fat Diet-Induced NAFLD Mice by Activating the PPARα Pathway.
Chen H, Ma Y, Qi X, Tian J, Ma Y, Niu T
Molecular nutrition & food research 2023 Aug;67(16):e2200499
Molecular nutrition & food research 2023 Aug;67(16):e2200499
A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease.
Sun Y, Xu L, Zheng D, Wang J, Liu G, Mo Z, Liu C, Zhang W, Yu J, Xing C, He L, Zhuang C
Redox biology 2023 Aug;64:102793
Redox biology 2023 Aug;64:102793
ETS1 Ameliorates Hyperoxia-Induced Bronchopulmonary Dysplasia in Mice by Activating Nrf2/HO-1 Mediated Ferroptosis.
Yang M, Chen Y, Huang X, Shen F, Meng Y
Lung 2023 Aug;201(4):425-441
Lung 2023 Aug;201(4):425-441
Endocytosis of red blood cell extracellular vesicles by macrophages leads to cytoplasmic heme release and prevents foam cell formation in atherosclerosis.
Pham TT, Le AH, Dang CP, Chong SY, Do DV, Peng B, Jayasinghe MK, Ong HB, Hoang DV, Louise RA, Loh YH, Hou HW, Wang JW, Le MT
Journal of extracellular vesicles 2023 Aug;12(8):e12354
Journal of extracellular vesicles 2023 Aug;12(8):e12354
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Wan D, Zhu Z, Zhou J, Deng Z, Lei P, Liu Q, Sun X, Huang B
Toxicology research 2023 Aug;12(4):635-647
Toxicology research 2023 Aug;12(4):635-647
Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma.
Jiang Z, Gao L, Liu C, Wang J, Han Y, Pan J
Journal of clinical and translational hepatology 2023 Aug 28;11(4):863-876
Journal of clinical and translational hepatology 2023 Aug 28;11(4):863-876
CXCL8 Promotes Endothelial-to-Mesenchymal Transition of Endothelial Cells and Protects Cells from Erastin-Induced Ferroptosis via CXCR2-Mediated Activation of the NF-κB Signaling Pathway.
Ji HZ, Chen L, Ren M, Li S, Liu TY, Chen HJ, Yu HH, Sun Y
Pharmaceuticals (Basel, Switzerland) 2023 Aug 25;16(9)
Pharmaceuticals (Basel, Switzerland) 2023 Aug 25;16(9)
Differential effects of PGAM5 knockout on high fat high fructose diet and methionine choline-deficient diet induced non-alcoholic steatohepatitis (NASH) in mice.
Li L, Guo C, Yu Y, Tie L, Lu G, Liu F, Han X, Ji L, Zou X
Cell & bioscience 2023 Aug 21;13(1):154
Cell & bioscience 2023 Aug 21;13(1):154
Retinoic acid protects against lipopolysaccharide-induced ferroptotic liver injury and iron disorders by regulating Nrf2/HO-1 and RARβ signaling.
Lai X, Wu A, Bing Y, Liu Y, Luo J, Yan H, Zheng P, Yu J, Chen D
Free radical biology & medicine 2023 Aug 20;205:202-213
Free radical biology & medicine 2023 Aug 20;205:202-213
The mitochondrial-derived peptide MOTS-c suppresses ferroptosis and alleviates acute lung injury induced by myocardial ischemia reperfusion via PPARγ signaling pathway.
Lu P, Li X, Li B, Li X, Wang C, Liu Z, Ji Y, Wang X, Wen Z, Fan J, Yi C, Song M, Wang X
European journal of pharmacology 2023 Aug 15;953:175835
European journal of pharmacology 2023 Aug 15;953:175835
Dihydromyricetin attenuates cisplatin-induced acute kidney injury by reducing oxidative stress, inflammation and ferroptosis.
Xu Z, Zhang M, Wang W, Zhou S, Yu M, Qiu X, Jiang S, Wang X, Tang C, Li S, Wang CH, Zhu R, Peng WX, Zhao L, Fu X, Patzak A, Persson PB, Zhao L, Mao J, Shu Q, Lai EY, Zhang G
Toxicology and applied pharmacology 2023 Aug 15;473:116595
Toxicology and applied pharmacology 2023 Aug 15;473:116595
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Gao Z, Zhan H, Zong W, Sun M, Linghu L, Wang G, Meng F, Chen M
Life sciences 2023 Aug 15;327:121793
Life sciences 2023 Aug 15;327:121793
Metalloporphyrins Reduce Proteinuria in Podocyte Immune Injury: The Role of Metal and Porphyrin Moieties.
Lianos EA, Phung GN, Foster M, Zhou J, Sharma M
International journal of molecular sciences 2023 Aug 14;24(16)
International journal of molecular sciences 2023 Aug 14;24(16)
Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota.
Huang W, Chen H, He Q, Xie W, Peng Z, Ma Q, Huang Q, Chen Z, Liu Y
Food & function 2023 Aug 14;14(16):7692-7704
Food & function 2023 Aug 14;14(16):7692-7704
Exosomes secreted by mesenchymal stem cells delay brain aging by upregulating SIRT1 expression.
Zhang X, Liu T, Hou X, Zhou Z, Zhang F, Ma H, Wu X, Jiang J
Scientific reports 2023 Aug 14;13(1):13213
Scientific reports 2023 Aug 14;13(1):13213
Nrf2 protects against methamphetamine-induced nephrotoxicity by mitigating oxidative stress and autophagy in mice.
Dong W, Wan J, Yu H, Shen B, Yang G, Nie Q, Tian Y, Qin L, Song C, Chen B, Li L, Hong S
Toxicology letters 2023 Aug 1;384:136-148
Toxicology letters 2023 Aug 1;384:136-148
Mucin2 regulated by Ho1/p38/IL-10 axis plays a protective role in polystyrene nanoplastics-mediated intestinal toxicity.
Cui M, He Q, Wang Z, Yu Y, Gao H, Liu Z, Peng H, Wang H, Zhang X, Li D, Chen L, Xing X, Xiao Y, Chen W, Wang Q
Environmental pollution (Barking, Essex : 1987) 2023 Aug 1;330:121808
Environmental pollution (Barking, Essex : 1987) 2023 Aug 1;330:121808
A small-molecule inhibitor of Keap1-Nrf2 interaction attenuates sepsis by selectively augmenting the antibacterial defence of macrophages at infection sites.
Wang Y, Tang B, Li H, Zheng J, Zhang C, Yang Z, Tan X, Luo P, Ma L, Wang Y, Long L, Chen Z, Xiao Z, Ma L, Zhou J, Wang Y, Shi C
EBioMedicine 2023 Apr;90:104480
EBioMedicine 2023 Apr;90:104480
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
Mechanisms regarding respiratory toxicity triggered by accumulation of ROS in carp exposed to difenoconazole.
Feng H, Chen H, Qiang J, Xu B, Wu X, Pan E, Yang H, Li X, Zhang J, Dong J
Pesticide biochemistry and physiology 2023 Apr;191:105343
Pesticide biochemistry and physiology 2023 Apr;191:105343
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
Liao W, Foo HYC, Tran TNQ, Chai CLL, Wong WSF
British journal of pharmacology 2023 Apr;180(8):1056-1071
British journal of pharmacology 2023 Apr;180(8):1056-1071
Ameliorative effects of different doses of selenium against fluoride-triggered apoptosis and oxidative stress-mediated renal injury in rats through the activation of Nrf2/HO-1/NQO1 signaling pathway.
Hu Y, Yan Z, He Y, Li Y, Li M, Li Y, Zhang D, Zhao Y, Ommati MM, Wang J, Huo M, Wang J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113647
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113647
Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs.
Li D, Shen L, Zhang D, Wang X, Wang Q, Qin W, Gao Y, Li X
Journal of environmental sciences (China) 2023 Apr;126:683-696
Journal of environmental sciences (China) 2023 Apr;126:683-696
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Dong C, Song C, He Z, Song Q, Song T, Liu J, Xiong Y, Su X, Zhou J, Yang S, Liao W
International immunopharmacology 2023 Apr;117:110042
International immunopharmacology 2023 Apr;117:110042
Tandem mass tag-based quantitative proteomics analysis reveals the effects of the α-lactalbumin peptides GINY and DQW on lipid deposition and oxidative stress in HepG2 cells.
Chen H, Qi X, Guan K, Wang R, Li Q, Ma Y
Journal of dairy science 2023 Apr;106(4):2271-2288
Journal of dairy science 2023 Apr;106(4):2271-2288
Water extract from Herpetospermum pedunculosum attenuates oxidative stress and ferroptosis induced by acetaminophen via regulating Nrf2 and NF-κB pathways.
Li J, Lu Q, Peng M, Liao J, Zhang B, Yang D, Huang P, Yang Y, Zhao Q, Han B, Li J
Journal of ethnopharmacology 2023 Apr 6;305:116069
Journal of ethnopharmacology 2023 Apr 6;305:116069
Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress.
Qiao P, Sun Y, Wang Y, Lin S, An Y, Wang L, Liu J, Huang Y, Yang B, Zhou H
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Ginsenoside Rh3 induces pyroptosis and ferroptosis through the Stat3/p53/NRF2 axis in colorectal cancer cells.
Wu Y, Pi D, Zhou S, Yi Z, Dong Y, Wang W, Ye H, Chen Y, Zuo Q, Ouyang M
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Acta biochimica et biophysica Sinica 2023 Apr 19;55(4):587-600
Blue LED light induces cytotoxicity via ROS production and mitochondrial damage in bovine subcutaneous preadipocytes.
Hao W, Zhao C, Li G, Wang H, Li T, Yan P, Wei S
Environmental pollution (Barking, Essex : 1987) 2023 Apr 1;322:121195
Environmental pollution (Barking, Essex : 1987) 2023 Apr 1;322:121195
N(6)-methyladenosine mediates Nrf2 protein expression involved in PM2.5-induced pulmonary fibrosis.
Ji D, Hu C, Ning J, Ying X, Zhang H, Zhang B, Liu B, Liu Q, Ji W, Zhang R
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
Ecotoxicology and environmental safety 2023 Apr 1;254:114755
PM(2.5) induce myocardial injury in hyperlipidemic mice through ROS-pyroptosis signaling pathway.
Jia R, Wei M, Lei J, Meng X, Du R, Yang M, Lu X, Jiang Y, Cao R, Wang L, Song L
Ecotoxicology and environmental safety 2023 Apr 1;254:114699
Ecotoxicology and environmental safety 2023 Apr 1;254:114699
Trans-anethole Ameliorates Intestinal Injury Through Activation of Nrf2 Signaling Pathway in Subclinical Necrotic Enteritis-Induced Broilers.
Yu C, Tong Y, Li Q, Wang T, Yang Z
Frontiers in veterinary science 2022;9:877066
Frontiers in veterinary science 2022;9:877066
Effects of limonin treatment on the survival of random skin flaps in mice.
Zhang T, Huang Q, Gan K, Zhou K, Hu K, Ding W, Jin J, Li J
Frontiers in surgery 2022;9:1043239
Frontiers in surgery 2022;9:1043239
Effects of folic acid on oxidative damage of kidney in lead-exposed rats.
Li N, Wen L, Yu Z, Li T, Wang T, Qiao M, Song L, Huang X
Frontiers in nutrition 2022;9:1035162
Frontiers in nutrition 2022;9:1035162
Tanshinone IIA Regulates Keap1/Nrf2 Signal Pathway by Activating Sestrin2 to Restrain Pulmonary Fibrosis.
Li H, Wu M, Guo C, Zhai R, Chen J
The American journal of Chinese medicine 2022;50(8):2125-2151
The American journal of Chinese medicine 2022;50(8):2125-2151
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide induces ferroptosis in neuroblastoma cells through redox imbalance.
Lyu Y, Ren XK, Guo CC, Li ZF, Zheng JP
The Journal of toxicological sciences 2022;47(12):519-529
The Journal of toxicological sciences 2022;47(12):519-529
Fibroblast Growth Factor 19 Improves LPS-Induced Lipid Disorder and Organ Injury by Regulating Metabolomic Characteristics in Mice.
Liu T, Tang X, Cui Y, Xiong X, Xu Y, Hu S, Feng S, Shao L, Ren Y, Miao H, Zhang H, Zhu X, Zhang Y, Wang C
Oxidative medicine and cellular longevity 2022;2022:9673512
Oxidative medicine and cellular longevity 2022;2022:9673512
The Attenuation of Chronic Ulcerative Colitis by (R)-salbutamol in Repeated DSS-Induced Mice.
Deng L, Guo H, Wang S, Liu X, Lin Y, Zhang R, Tan W
Oxidative medicine and cellular longevity 2022;2022:9318721
Oxidative medicine and cellular longevity 2022;2022:9318721
Senotherapy Protects against Cisplatin-Induced Ovarian Injury by Removing Senescent Cells and Alleviating DNA Damage.
Du D, Tang X, Li Y, Gao Y, Chen R, Chen Q, Wen J, Wu T, Zhang Y, Lu H, Zhang J, Wang S
Oxidative medicine and cellular longevity 2022;2022:9144644
Oxidative medicine and cellular longevity 2022;2022:9144644
Activation of the P62-Keap1-NRF2 Pathway Protects against Ferroptosis in Radiation-Induced Lung Injury.
Li X, Chen J, Yuan S, Zhuang X, Qiao T
Oxidative medicine and cellular longevity 2022;2022:8973509
Oxidative medicine and cellular longevity 2022;2022:8973509
Dl-3-n-Butylphthalide Improves Neuroinflammation in Mice with Repeated Cerebral Ischemia-Reperfusion Injury through the Nrf2-Mediated Antioxidant Response and TLR4/MyD88/NF-κB Signaling Pathway.
Gao Y, Hu M, Niu X, Li M, Xu L, Xiao Y, Zhang J, Wang H, Li L, Chu B, Lv P
Oxidative medicine and cellular longevity 2022;2022:8652741
Oxidative medicine and cellular longevity 2022;2022:8652741
TUG1/MAZ/FTH1 Axis Attenuates the Antiglioma Effect of Dihydroartemisinin by Inhibiting Ferroptosis.
Gong H, Gao M, Lin Y, Liu J, Hu Z, Liu J
Oxidative medicine and cellular longevity 2022;2022:7843863
Oxidative medicine and cellular longevity 2022;2022:7843863
Effect of Thymoquinone on Renal Damage Induced by Hyperlipidemia in LDL Receptor-Deficient (LDL-R(-)/(-)) Mice.
Li W, Zhang H, Zhang L, Zhang T, Ding H
BioMed research international 2022;2022:7709926
BioMed research international 2022;2022:7709926
Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.
Wang P, Zhang S, Liu W, Chen S, Lv X, Hu B, Shao Z
Oxidative medicine and cellular longevity 2022;2022:7531788
Oxidative medicine and cellular longevity 2022;2022:7531788
Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway.
Zhang B, Wan S, Liu H, Qiu Q, Chen H, Chen Z, Wang L, Liu X
Oxidative medicine and cellular longevity 2022;2022:5992436
Oxidative medicine and cellular longevity 2022;2022:5992436
Amentoflavone Exerts Anti-Neuroinflammatory Effects by Inhibiting TLR4/MyD88/NF-κB and Activating Nrf2/HO-1 Pathway in Lipopolysaccharide-Induced BV2 Microglia.
Rong S, Yang C, Wang F, Wu Y, Sun K, Sun T, Wu Z
Mediators of inflammation 2022;2022:5184721
Mediators of inflammation 2022;2022:5184721
Protective Effects of Cannabidiol on Chemotherapy-Induced Oral Mucositis via the Nrf2/Keap1/ARE Signaling Pathways.
Li L, Xuan Y, Zhu B, Wang X, Tian X, Zhao L, Wang Y, Jiang X, Wen N
Oxidative medicine and cellular longevity 2022;2022:4619760
Oxidative medicine and cellular longevity 2022;2022:4619760
Theaflavin-3,3'-Digallate Inhibits Erastin-Induced Chondrocytes Ferroptosis via the Nrf2/GPX4 Signaling Pathway in Osteoarthritis.
Xu C, Ni S, Xu N, Yin G, Yu Y, Zhou B, Zhao G, Wang L, Zhu R, Jiang S, Wang Y
Oxidative medicine and cellular longevity 2022;2022:3531995
Oxidative medicine and cellular longevity 2022;2022:3531995
GSK 650394 Inhibits Osteoclasts Differentiation and Prevents Bone Loss via Promoting the Activities of Antioxidant Enzymes In Vitro and In Vivo.
Jin LY, Huo SC, Guo C, Liu HY, Xu S, Li XF
Oxidative medicine and cellular longevity 2022;2022:3458560
Oxidative medicine and cellular longevity 2022;2022:3458560
Discovery of Therapeutic Candidates for Diabetic Retinopathy Based on Molecular Switch Analysis: Application of a Systematic Process.
Ren Y, Liu Y, Liu K, Huo X, Liu C, Zhang Y
Oxidative medicine and cellular longevity 2022;2022:3412032
Oxidative medicine and cellular longevity 2022;2022:3412032
Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.
Teng Y, Jin Z, Ren W, Lu M, Hou M, Zhou Q, Wang W, Yang H, Zou J
Oxidative medicine and cellular longevity 2022;2022:3047425
Oxidative medicine and cellular longevity 2022;2022:3047425
Streptococcus lutetiensis Induces Autophagy via Oxidative Stress in Bovine Mammary Epithelial Cells.
Chen P, Yang J, Wu N, Han B, Kastelic JP, Gao J
Oxidative medicine and cellular longevity 2022;2022:2549772
Oxidative medicine and cellular longevity 2022;2022:2549772
Geraniin Protects against Cerebral Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Neuronal Apoptosis via Regulation of the Nrf2/HO-1 Pathway.
Yang Y, He B, Zhang X, Yang R, Xia X, Chen L, Li R, Shen Z, Chen P
Oxidative medicine and cellular longevity 2022;2022:2152746
Oxidative medicine and cellular longevity 2022;2022:2152746
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Wang L, Wang J
Oxidative medicine and cellular longevity 2022;2022:1755608
Oxidative medicine and cellular longevity 2022;2022:1755608
Maltol Promotes Mitophagy and Inhibits Oxidative Stress via the Nrf2/PINK1/Parkin Pathway after Spinal Cord Injury.
Mao Y, Du J, Chen X, Al Mamun A, Cao L, Yang Y, Mubwandarikwa J, Zaeem M, Zhang W, Chen Y, Dai Y, Xiao J, Ye K
Oxidative medicine and cellular longevity 2022;2022:1337630
Oxidative medicine and cellular longevity 2022;2022:1337630
Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection.
Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z, Wang Q, Li Y, Zhong X, Li R, Zhu XH, Fang Z, Wei X, Jiang DS
International journal of biological sciences 2022;18(10):4118-4134
International journal of biological sciences 2022;18(10):4118-4134
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H
Drug design, development and therapy 2022;16:279-296
Drug design, development and therapy 2022;16:279-296
Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress.
Jia Z, Wang P, Xu Y, Feng G, Wang Q, He X, Song Y, Liu P, Chen J
Frontiers in pharmacology 2022;13:986510
Frontiers in pharmacology 2022;13:986510
Activated AMP-activated protein kinase prevents hepatic steatosis, oxidative stress and inflammation in primary chicken hepatocytes.
Yao Y, Li L, Wang H, Yang Y, Ma H
Frontiers in physiology 2022;13:974825
Frontiers in physiology 2022;13:974825
Nodosin Exerts an Anti-Colorectal Cancer Effect by Inhibiting Proliferation and Triggering Complex Cell Death in Vitro and in Vivo.
Fan H, Hao X, Gao Y, Yang J, Liu A, Su Y, Xia Y
Frontiers in pharmacology 2022;13:943272
Frontiers in pharmacology 2022;13:943272
(±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to H(2)O(2) Through Activation of Nrf2 Pathway.
Qi S, Zhang X, Fu Z, Pi A, Shi F, Fan Y, Zhang J, Xiao T, Shang D, Lin M, Gao N, Chang J, Gao Y
Frontiers in pharmacology 2022;13:943111
Frontiers in pharmacology 2022;13:943111
Co-Treatment With Resveratrol and FGF1 Protects Against Acute Liver Toxicity After Doxorubicin Treatment via the AMPK/NRF2 Pathway.
Xu X, Liu Q, Li J, Xiao M, Gao T, Zhang X, Lu G, Wang J, Guo Y, Wen P, Gu J
Frontiers in pharmacology 2022;13:940406
Frontiers in pharmacology 2022;13:940406
Inhibition of fucosylation by 2-fluorofucose attenuated acetaminophen-induced liver injury via its anti-inflammation and anti-oxidative stress effects.
Liu Z, Tu M, Shi J, Zhou H, Meng G, Gu J, Wang Y
Frontiers in pharmacology 2022;13:939317
Frontiers in pharmacology 2022;13:939317
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Yang T, Lin X, Li H, Zhou X, Fan F, Yang J, Luo Y, Liu X
Frontiers in pharmacology 2022;13:927871
Frontiers in pharmacology 2022;13:927871
Relief Effects of Icariin on Inflammation-Induced Decrease of Tight Junctions in Intestinal Epithelial Cells.
Li Y, Liu J, Pongkorpsakol P, Xiong Z, Li L, Jiang X, Zhao H, Yuan D, Zhang C, Guo Y, Dun Y
Frontiers in pharmacology 2022;13:903762
Frontiers in pharmacology 2022;13:903762
Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs.
Li D, Zhao H, Xu P, Lin Q, Zhao T, Li C, Cui ZK, Tian G
Frontiers in pharmacology 2022;13:887833
Frontiers in pharmacology 2022;13:887833
4-Ethylguaiacol Modulates Neuroinflammation and Promotes Heme Oxygenase-1 Expression to Ameliorate Brain Injury in Ischemic Stroke.
Weng WT, Kuo PC, Scofield BA, Paraiso HC, Brown DA, Yu IC, Yen JH
Frontiers in immunology 2022;13:887000
Frontiers in immunology 2022;13:887000
Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway.
Hu X, Li C, Wang Q, Wei Z, Chen T, Wang Y, Li Y
Frontiers in pharmacology 2022;13:872057
Frontiers in pharmacology 2022;13:872057
Scorias spongiosa Polysaccharides Promote the Antioxidant and Anti-Inflammatory Capacity and Its Effect on Intestinal Microbiota in Mice.
Xu Y, Zhang Z, Feng H, Tang J, Peng W, Chen Y, Zhou J, Wang Y
Frontiers in microbiology 2022;13:865396
Frontiers in microbiology 2022;13:865396
Kaempferol From Penthorum chinense Pursh Attenuates Hepatic Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Inflammation Through Activation of the Nrf2/HO-1 Signaling Pathway.
Chen Y, Li T, Tan P, Shi H, Cheng Y, Cai T, Bai J, Du Y, Fu W
Frontiers in pharmacology 2022;13:857015
Frontiers in pharmacology 2022;13:857015
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Chen R, Zeng J, Li C, Xiao H, Li S, Lin Z, Huang K, Shen J, Huang H
Frontiers in pharmacology 2022;13:853383
Frontiers in pharmacology 2022;13:853383
Cyclophosphamide Induces the Ferroptosis of Tumor Cells Through Heme Oxygenase-1.
Shi H, Hou B, Li H, Zhou H, Du B
Frontiers in pharmacology 2022;13:839464
Frontiers in pharmacology 2022;13:839464
A Novel Compound, Tanshinol Borneol Ester, Ameliorates Pressure Overload-Induced Cardiac Hypertrophy by Inhibiting Oxidative Stress via the mTOR/β-TrCP/NRF2 Pathway.
Han D, Wang F, Wang B, Qiao Z, Cui X, Zhang Y, Jiang Q, Liu M, Shangguan J, Zheng X, Bai Y, Du C, Shen D
Frontiers in pharmacology 2022;13:830763
Frontiers in pharmacology 2022;13:830763
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.
Guo Z, Lin J, Sun K, Guo J, Yao X, Wang G, Hou L, Xu J, Guo J, Guo F
Frontiers in pharmacology 2022;13:791376
Frontiers in pharmacology 2022;13:791376
Zoledronic acid induces ferroptosis by reducing ubiquinone and promoting HMOX1 expression in osteosarcoma cells.
Ren T, Huang J, Sun W, Wang G, Wu Y, Jiang Z, Lv Y, Wu G, Cao J, Liu M, Gu H
Frontiers in pharmacology 2022;13:1071946
Frontiers in pharmacology 2022;13:1071946
Cryptotanshinone protects skin cells from ultraviolet radiation-induced photoaging via its antioxidant effect and by reducing mitochondrial dysfunction and inhibiting apoptosis.
Guo K, Liu R, Jing R, Wang L, Li X, Zhang K, Fu M, Ye J, Hu Z, Zhao W, Xu N
Frontiers in pharmacology 2022;13:1036013
Frontiers in pharmacology 2022;13:1036013
Berberine prevents lethal EV71 neurological infection in newborn mice.
Cui G, Wang H, Yang C, Zhou X, Wang J, Wang T, Ma T
Frontiers in pharmacology 2022;13:1027566
Frontiers in pharmacology 2022;13:1027566
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.
Ma T, Jia L, Zhao J, Lv L, Yu Y, Ruan H, Song X, Chen H, Li X, Zhang J, Gao L
Frontiers in pharmacology 2022;13:1027553
Frontiers in pharmacology 2022;13:1027553
Sunitinib induced hepatotoxicity in L02 cells via ROS-MAPKs signaling pathway.
Tang TL, Yang Y, Guo L, Xia S, Zhang B, Yan M
Frontiers in pharmacology 2022;13:1002142
Frontiers in pharmacology 2022;13:1002142
Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.
Jing S, Wan J, Wang T, He Z, Ding Q, Sheng G, Wang S, Zhao H, Zhu Z, Wu H, Li W
Frontiers in bioengineering and biotechnology 2022;10:1071776
Frontiers in bioengineering and biotechnology 2022;10:1071776
Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response.
De Backer J, Lin A, Berghe WV, Bogaerts A, Hoogewijs D
Redox biology 2022 Sep;55:102399
Redox biology 2022 Sep;55:102399
Protective effects of di-caffeoylquinic acids from Artemisia selengensis Turcz leaves against monosodium urate-induced inflammation via the modulation of NLRP3 inflammasome and Nrf2 signaling pathway in THP-1 macrophages.
Cao W, Wu T, Liang F, Fang Y, Cheng Y, Pan S, Xu X
Journal of food biochemistry 2022 Sep;46(9):e14252
Journal of food biochemistry 2022 Sep;46(9):e14252
Dendrobium officinale polysaccharide inhibits vascular calcification via anti-inflammatory and anti-apoptotic effects in chronic kidney disease.
Jiang W, Ruan W, Wang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22504
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22504
Protective Mechanism of Electroacupuncture on Peripheral Neurotoxicity Induced by Oxaliplatin in Rats.
Wang FJ, Shi S, Wang YQ, Wang K, Fan SD, Zhang YN, Feng CC, Ju ZY
Chinese journal of integrative medicine 2022 Sep;28(9):833-839
Chinese journal of integrative medicine 2022 Sep;28(9):833-839
Colchicine improves severe acute pancreatitis-induced acute lung injury by suppressing inflammation, apoptosis and oxidative stress in rats.
Zhang D, Li L, Li J, Wei Y, Tang J, Man X, Liu F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113461
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113461
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Shen Y, Fan X, Qu Y, Tang M, Huang Y, Peng Y, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Hedyotis diffusa injection induces ferroptosis via the Bax/Bcl2/VDAC2/3 axis in lung adenocarcinoma.
Huang F, Pang J, Xu L, Niu W, Zhang Y, Li S, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154319
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154319
Resveratrol and FGF1 Synergistically Ameliorates Doxorubicin-Induced Cardiotoxicity via Activation of SIRT1-NRF2 Pathway.
Lu G, Liu Q, Gao T, Li J, Zhang J, Chen O, Cao C, Mao M, Xiao M, Zhang X, Wang J, Guo Y, Tang Y, Gu J
Nutrients 2022 Sep 27;14(19)
Nutrients 2022 Sep 27;14(19)
Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway.
Luo JF, Zhou H, Lio CK
Molecules (Basel, Switzerland) 2022 Sep 22;27(19)
Molecules (Basel, Switzerland) 2022 Sep 22;27(19)
Targeting NRF2 Sensitizes Esophageal Adenocarcinoma Cells to Cisplatin through Induction of Ferroptosis and Apoptosis.
Ballout F, Lu H, Chen Z, Hu T, Chen L, Washington MK, El-Rifai W, Peng D
Antioxidants (Basel, Switzerland) 2022 Sep 21;11(10)
Antioxidants (Basel, Switzerland) 2022 Sep 21;11(10)
Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway.
Lin Y, Zhang Q, Xie B, Jiang H, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Eugenol Attenuates Transmissible Gastroenteritis Virus-Induced Oxidative Stress and Apoptosis Via ROS-NRF2-ARE Signaling.
Wang K, Tang Y, Wu X, Liang H, Chen D, Yu B, He J, Mao X, Huang Z, Yan H, Wu A, Luo Y, Zheng P, Yu J, Wang H, Luo J
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells.
Zhang XG, Liu AX, Zhang YX, Zhou MY, Li XY, Fu MH, Pan YP, Xu J, Zhang JQ
Journal of ethnopharmacology 2022 Sep 15;295:115397
Journal of ethnopharmacology 2022 Sep 15;295:115397
Carbon tetrachloride exposure induces ovarian damage through oxidative stress and inflammatory mediated ovarian fibrosis.
Xue L, Li X, Zhu X, Zhang J, Zhou S, Tang W, Chen D, Chen Y, Dai J, Wu M, Wu M, Wang S
Ecotoxicology and environmental safety 2022 Sep 1;242:113859
Ecotoxicology and environmental safety 2022 Sep 1;242:113859
Quercetin in Tonglong Qibi decoction ameliorates testosterone-induced benign prostatic hyperplasia in rats by regulating Nrf2 signalling pathways and oxidative stress.
Fu W, Chen S, Zhang Z, Chen Y, You X, Li Q
Andrologia 2022 Oct;54(9):e14502
Andrologia 2022 Oct;54(9):e14502
1,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes.
Guan S, Zhang R, Zhao Y, Meng Z, Lu J
Environmental toxicology 2022 Oct;37(10):2515-2528
Environmental toxicology 2022 Oct;37(10):2515-2528
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO-1 signaling pathway in mice.
Xu L, Gao Y, Hu M, Dong Y, Xu J, Zhang J, Lv P
Fundamental & clinical pharmacology 2022 Oct;36(5):790-800
Fundamental & clinical pharmacology 2022 Oct;36(5):790-800
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis.
Wang Z, Yao M, Jiang L, Wang L, Yang Y, Wang Q, Qian X, Zhao Y, Qian J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113572
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113572
LipoxinA(4) analog BML-111 protects podocytes cultured in high-glucose medium against oxidative injury via activating Nrf2 pathway.
Hao H, Xie F, Xu F, Wang Q, Wu Y, Zhang D
International immunopharmacology 2022 Oct;111:109170
International immunopharmacology 2022 Oct;111:109170
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
Sodium butyrate reduces overnutrition-induced microglial activation and hypothalamic inflammation.
Wang X, Duan C, Li Y, Lu H, Guo K, Ge X, Chen T, Shang Y, Liu H, Zhang D
International immunopharmacology 2022 Oct;111:109083
International immunopharmacology 2022 Oct;111:109083
Gandouling Mitigates CuSO(4)-Induced Heart Injury in Rats.
Fang S, Yang W, Zhang K, Peng C
Animals : an open access journal from MDPI 2022 Oct 8;12(19)
Animals : an open access journal from MDPI 2022 Oct 8;12(19)
Preparation of curcumin-loaded cochleates: characterisation, stability and antioxidant properties.
Chen L, Yue B, Liu Z, Luo Y, Ni L, Shen W, Zhou Z, Ge X
Food & function 2022 Oct 31;13(21):11273-11282
Food & function 2022 Oct 31;13(21):11273-11282
Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease.
Zhao H, Xian G, Zeng J, Zhong G, An D, Peng Y, Hu D, Lin Y, Li J, Su S, Ning Y, Xu D, Zeng Q
Antioxidants (Basel, Switzerland) 2022 Oct 24;11(11)
Antioxidants (Basel, Switzerland) 2022 Oct 24;11(11)
Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
Ye Q, Taleb SJ, Wang H, Parinandi NL, Kass DJ, Rojas M, Wang C, Ma Q, Zhao J, Zhao Y
Biomolecules 2022 Oct 21;12(10)
Biomolecules 2022 Oct 21;12(10)
Integrated Analysis of Transcriptome and microRNA Profile Reveals the Toxicity of Euphorbia Factors toward Human Colon Adenocarcinoma Cell Line Caco-2.
Zou L, Bao W, Gao Y, Chen M, Wu Y, Wang S, Li C, Zhang J, Zhang D, Wang Q, Zhu A
Molecules (Basel, Switzerland) 2022 Oct 16;27(20)
Molecules (Basel, Switzerland) 2022 Oct 16;27(20)
p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression.
Fan S, Huang X, Tong H, Hong H, Lai Z, Hu W, Liu X, Zhang L, Jiang Z, Yu Q
European journal of pharmacology 2022 Oct 15;933:175277
European journal of pharmacology 2022 Oct 15;933:175277
Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells.
Zhao Y, Zhang R, Wang Z, Chen Z, Wang G, Guan S, Lu J
Journal of agricultural and food chemistry 2022 Oct 12;70(40):12953-12967
Journal of agricultural and food chemistry 2022 Oct 12;70(40):12953-12967
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Xiong L, Wu H, Zhong T, Luo F, Li Q, Li M, Fan Y
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway.
Guo J, Yang X, Chen J, Wang C, Kang Y, Jiang T, Chen M, Li W, Zhou C, Chen Z
ACS biomaterials science & engineering 2022 Oct 10;8(10):4524-4534
ACS biomaterials science & engineering 2022 Oct 10;8(10):4524-4534
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Liu F, Wang Y, Chen L, Bello BK, Zhang T, Yang H, Li X, Pan E, Feng H, Dong J
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.
Sun W, Xie W, Huang D, Cui Y, Yue J, He Q, Jiang L, Xiong J, Sun W, Yi Q
International journal of molecular medicine 2022 Nov;50(5)
International journal of molecular medicine 2022 Nov;50(5)
OL-FS13 alleviates experimental cerebral ischemia-reperfusion injury.
Liu N, Li Y, Yang Y, Shu L, Liu Y, Wu Y, Sun D, Kang Z, Zhang Y, Ni D, Wei Z, Li S, Yang M, Wang Y, Sun J, Yang X
Experimental neurology 2022 Nov;357:114180
Experimental neurology 2022 Nov;357:114180
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
Wang Y, Zhu M, Liang J, Zhang N, Sun D, Li H, Chen L
Bioorganic chemistry 2022 Nov;128:106067
Bioorganic chemistry 2022 Nov;128:106067
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6.
Liao L, Dang W, Lin T, Yu J, Liu T, Li W, Xiao S, Feng L, Huang J, Fu R, Li J, Liu L, Wang M, Tao H, Jiang H, Chen K, Diao X, Zhou B, Shen X, Luo C
Acta pharmaceutica Sinica. B 2022 Nov;12(11):4180-4192
Acta pharmaceutica Sinica. B 2022 Nov;12(11):4180-4192
Melatonin suppresses ferroptosis via activation of the Nrf2/HO-1 signaling pathway in the mouse model of sepsis-induced acute kidney injury.
Qiu W, An S, Wang T, Li J, Yu B, Zeng Z, Chen Z, Lin B, Lin X, Gao Y
International immunopharmacology 2022 Nov;112:109162
International immunopharmacology 2022 Nov;112:109162
Gallic acid ameliorates calcium oxalate crystal-induced renal injury via upregulation of Nrf2/HO-1 in the mouse model of stone formation.
Zhou D, Wu Y, Yan H, Shen T, Li S, Gong J, Li G, Mai H, Wang D, Tan X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154429
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154429
5-Methoxyflavone alleviates LPS-mediated lung injury by promoting Nrf2-mediated the suppression of NOX4/TLR4 axis in bronchial epithelial cells and M1 polarization in macrophages.
Liang P, Wang L, Yang S, Pan X, Li J, Zhang Y, Liang Y, Li J, Zhou B
Journal of inflammation (London, England) 2022 Nov 30;19(1):24
Journal of inflammation (London, England) 2022 Nov 30;19(1):24
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.
Jin Y, Zhang Q, Qin X, Liu Z, Li Z, Zhong X, Xia L, He J, Fang B
Journal of nanobiotechnology 2022 Nov 3;20(1):469
Journal of nanobiotechnology 2022 Nov 3;20(1):469
Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis.
Kong K, Chang Y, Qiao H, Zhao C, Chen X, Rong K, Zhang P, Jin M, Zhang J, Li H, Zhai Z
Journal of translational medicine 2022 Nov 26;20(1):549
Journal of translational medicine 2022 Nov 26;20(1):549
BP5 alleviates endotoxemia-induced acute lung injury by activating Nrf2 via dual regulation of the Keap1-Nrf2 interaction and the Akt (Ser473)/GSK3β (Ser9)/Fyn pathway.
Li T, Geng Z, Zhang J, Xu L, Zhu X
Free radical biology & medicine 2022 Nov 20;193(Pt 1):304-318
Free radical biology & medicine 2022 Nov 20;193(Pt 1):304-318
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Zhang D, Li X, He X, Xing Y, Jiang B, Xiu Z, Bao Y, Dong Y
Molecules (Basel, Switzerland) 2022 Nov 12;27(22)
Molecules (Basel, Switzerland) 2022 Nov 12;27(22)
Aberrant expression of KDM1A inhibits ferroptosis of lung cancer cells through up-regulating c-Myc.
Lu C, Cai Y, Liu W, Peng B, Liang Q, Yan Y, Liang D, Xu Z
Scientific reports 2022 Nov 10;12(1):19168
Scientific reports 2022 Nov 10;12(1):19168
Silibinin improves L-cell mass and function through an estrogen receptor-mediated antioxidative mechanism.
Wang J, Zhang L, Cao H, Shi X, Zhang X, Gao Z, Ikeda K, Yan T, Jia Y, Xu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154022
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:154022
Collagen peptides from Acaudina molpadioides prevent CCl(4) -induced liver injury via Keap1/Nrf2-ARE, PI3K/AKT, and MAPKs pathways.
Li J, Li Y, Lin S, Zhao W, Chen Y, Jin H
Journal of food science 2022 May;87(5):2185-2196
Journal of food science 2022 May;87(5):2185-2196
Protective effect of rutin against diabetes-associated cognitive decline in rats.
Xianchu L, Huan P, Kang L, Beiwang D, Ming L
Pakistan journal of pharmaceutical sciences 2022 May;35(3):769-775
Pakistan journal of pharmaceutical sciences 2022 May;35(3):769-775
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury.
Zhao R, Wang L, Wang T, Xian P, Wang H, Long Q
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
Journal of controlled release : official journal of the Controlled Release Society 2022 May;345:214-230
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Zhou S, Li J, Zhang X, Xiong W
Bioengineered 2022 May;13(5):13507-13519
Bioengineered 2022 May;13(5):13507-13519
Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury.
Zheng J, Wang Y, Wang Z, Chen W, Luo M, Zhang C, Wang Y, Chen L, Wu F, Yang W, Yang Z, Wang Y, Shi C
Free radical research 2022 May-Jun;56(5-6):411-426
Free radical research 2022 May-Jun;56(5-6):411-426
ROS-responsive liposomes as an inhaled drug delivery nanoplatform for idiopathic pulmonary fibrosis treatment via Nrf2 signaling.
Liu J, Wu Z, Liu Y, Zhan Z, Yang L, Wang C, Jiang Q, Ran H, Li P, Wang Z
Journal of nanobiotechnology 2022 May 6;20(1):213
Journal of nanobiotechnology 2022 May 6;20(1):213
A Combination therapy using an mTOR inhibitor and Honokiol effectively induces autophagy through the modulation of AXL and Rubicon in renal cancer cells and restricts renal tumor growth following organ transplantation.
Sabarwal A, Wedel J, Liu K, Zurakowski D, Chakraborty S, Flynn E, Briscoe DM, Balan M, Pal S
Carcinogenesis 2022 May 19;43(4):360-370
Carcinogenesis 2022 May 19;43(4):360-370
Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNA‑binding protein RBFOX1 in this disease.
Lin F, Xu L, Yuan R, Han S, Xie J, Jiang K, Li B, Yu W, Rao T, Zhou X, Cheng F
International journal of molecular medicine 2022 Mar;49(3)
International journal of molecular medicine 2022 Mar;49(3)
Quercetin attenuates ischemia reperfusion injury by protecting the blood-brain barrier through Sirt1 in MCAO rats.
Yang R, Shen YJ, Chen M, Zhao JY, Chen SH, Zhang W, Song JK, Li L, Du GH
Journal of Asian natural products research 2022 Mar;24(3):278-289
Journal of Asian natural products research 2022 Mar;24(3):278-289
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F
Biochemical pharmacology 2022 Mar;197:114932
Biochemical pharmacology 2022 Mar;197:114932
HMGB2 causes photoreceptor death via down-regulating Nrf2/HO-1 and up-regulating NF-κB/NLRP3 signaling pathways in light-induced retinal degeneration model.
Zhang Y, Zhao Z, Zhao X, Xie H, Zhang C, Sun X, Zhang J
Free radical biology & medicine 2022 Mar;181:14-28
Free radical biology & medicine 2022 Mar;181:14-28
BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection.
Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z, Zhong X, Feng X, Fang ZM, Zhu XH, Wei X, Jiang DS
Pharmacological research 2022 Mar;177:106122
Pharmacological research 2022 Mar;177:106122
Phenotypic characterization of Cdkl5-knockdown neurons establishes elongated cilia as a functional assay for CDKL5 Deficiency Disorder.
Di Nardo A, Rühmkorf A, Award P, Brennecke A, Fagiolini M, Sahin M
Neuroscience research 2022 Mar;176:73-78
Neuroscience research 2022 Mar;176:73-78
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
Zhang W, Dun Y, You B, Qiu L, Ripley-Gonzalez JW, Cheng J, Fu S, Li C, Liu S
BMJ open diabetes research & care 2022 Mar;10(2)
BMJ open diabetes research & care 2022 Mar;10(2)
DHA-Enriched Phospholipids and EPA-Enriched Phospholipids Alleviate Lipopolysaccharide-Induced Intestinal Barrier Injury in Mice via a Sirtuin 1-Dependent Mechanism.
Du L, Hao YM, Yang YH, Zheng Y, Wu ZJ, Zhou MQ, Wang BZ, Wang YM, Wu H, Su GH
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2911-2922
Journal of agricultural and food chemistry 2022 Mar 9;70(9):2911-2922
Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis.
Yang Y, Lin Y, Wang M, Yuan K, Wang Q, Mu P, Du J, Yu Z, Yang S, Huang K, Wang Y, Li H, Tang T
Bone research 2022 Mar 9;10(1):26
Bone research 2022 Mar 9;10(1):26
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.
Meng N, Chen K, Wang Y, Hou J, Chu W, Xie S, Yang F, Sun C
Molecules (Basel, Switzerland) 2022 Mar 19;27(6)
Molecules (Basel, Switzerland) 2022 Mar 19;27(6)
Ruscogenin Alleviates Myocardial Ischemia-Induced Ferroptosis through the Activation of BCAT1/BCAT2.
Fu F, Lai Q, Hu J, Zhang L, Zhu X, Kou J, Yu B, Li F
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
2-Fluorofucose Attenuates Hydrogen Peroxide-Induced Oxidative Stress in HepG2 Cells via Nrf2/keap1 and NF-κB Signaling Pathways.
Tu M, Fan X, Shi J, Jing S, Xu X, Wang Y
Life (Basel, Switzerland) 2022 Mar 11;12(3)
Life (Basel, Switzerland) 2022 Mar 11;12(3)
Lipoxin A(4) and its analog attenuate high fat diet-induced atherosclerosis via Keap1/Nrf2 pathway.
Xu F, Zhang J, Zhou X, Hao H
Experimental cell research 2022 Mar 1;412(1):113025
Experimental cell research 2022 Mar 1;412(1):113025
Nephrotoxicity evaluation of 3-monochloropropane-1,2-diol exposure in Sprague-Dawley rats using data-independent acquisition-based quantitative proteomics analysis.
Jin C, Min F, Zhong Y, Sun D, Luo R, Liu Q, Peng X
Toxicology letters 2022 Mar 1;356:110-120
Toxicology letters 2022 Mar 1;356:110-120
Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2.
Wang A J, Tang Y, Zhang J, Wang B J, Xiao M, Lu G, Li J, Liu Q, Guo Y, Gu J
Redox biology 2022 Jun;52:102310
Redox biology 2022 Jun;52:102310
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
Zhai X, Dai T, Chi Z, Zhao Z, Wu G, Yang S, Dong D
Environmental toxicology 2022 Jun;37(6):1332-1342
Environmental toxicology 2022 Jun;37(6):1332-1342
Antagonistic effects of selenium on lead-induced oxidative stress and apoptosis of Leydig cells in sheep.
Shi L, Wang X, Duan Y, Li K, Ren Y
Theriogenology 2022 Jun;185:43-49
Theriogenology 2022 Jun;185:43-49
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells.
Li S, Ma Y, Ye S, Su Y, Hu D, Xiao F
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113071
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113071
Different cellular mechanisms from low- and high-dose zinc oxide nanoparticles-induced heart tube malformation during embryogenesis.
Wang M, Zhang P, Li Z, Yan Y, Cheng X, Wang G, Yang X
Nanotoxicology 2022 Jun;16(5):580-596
Nanotoxicology 2022 Jun;16(5):580-596
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation.
Zhang D, Ren Y, He Y, Chang R, Guo S, Ma S, Guan F, Yao M
Materials today. Bio 2022 Jun;15:100278
Materials today. Bio 2022 Jun;15:100278
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Zhong T, Li M, Wu H, Wang D, Liu J, Xu Y, Fan Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Yin BF, Li ZL, Yan ZQ, Guo Z, Liang JW, Wang Q, Zhao ZD, Li PL, Hao RC, Han MY, Li XT, Mao N, Ding L, Chen DF, Gao Y, Zhu H
Stem cell research & therapy 2022 Jun 7;13(1):241
Stem cell research & therapy 2022 Jun 7;13(1):241
Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration.
Peng J, Cai Z, Wang Q, Zhou J, Xu J, Pan D, Chen T, Zhang G, Tao L, Chen Y, Shen X
Molecules (Basel, Switzerland) 2022 Jun 4;27(11)
Molecules (Basel, Switzerland) 2022 Jun 4;27(11)
Early-life galacto-oligosaccharides supplementation alleviates the small intestinal oxidative stress and dysfunction of lipopolysaccharide-challenged suckling piglets.
Tian S, Wang J, Gao R, Wang J, Zhu W
Journal of animal science and biotechnology 2022 Jun 3;13(1):70
Journal of animal science and biotechnology 2022 Jun 3;13(1):70
Novel Probiotic Lactic Acid Bacteria Were Identified from Healthy Infant Feces and Exhibited Anti-Inflammatory Capacities.
Li B, Pan LL, Sun J
Antioxidants (Basel, Switzerland) 2022 Jun 24;11(7)
Antioxidants (Basel, Switzerland) 2022 Jun 24;11(7)
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Zhou X, Wang S, Zhou R, Zhang T, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhou X, Song N
Toxicology 2022 Jun 15;475:153227
Toxicology 2022 Jun 15;475:153227
Selenium Status in Diet Affects Nephrotoxicity Induced by Cisplatin in Mice.
Liu S, Wen X, Huang Q, Zhu M, Lu J
Antioxidants (Basel, Switzerland) 2022 Jun 10;11(6)
Antioxidants (Basel, Switzerland) 2022 Jun 10;11(6)
Mitigation of doxorubicin-induced cardiotoxicity with an H(2)O(2)-Activated, H(2)S-Donating hybrid prodrug.
Hu Q, Yammani RD, Brown-Harding H, Soto-Pantoja DR, Poole LB, Lukesh JC 3rd
Redox biology 2022 Jul;53:102338
Redox biology 2022 Jul;53:102338
Ophiopogonin D'-induced mitophagy and mitochondrial damage are associated with dysregulation of the PINK1/Parkin signaling pathway in AC16 cells.
Lei S, Feng Y, Huang P, Chen B, Bao K, Wu Q, Zhang H, Huang X
Toxicology 2022 Jul;477:153275
Toxicology 2022 Jul;477:153275
Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.
Luo P, Huang Q, Chen S, Wang Y, Dou H
International immunopharmacology 2022 Jul;108:108864
International immunopharmacology 2022 Jul;108:108864
Maackiain protects against sepsis via activating AMPK/Nrf2/HO-1 pathway.
Bai X, Zhu Y, Jie J, Li D, Song L, Luo J
International immunopharmacology 2022 Jul;108:108710
International immunopharmacology 2022 Jul;108:108710
Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.
Zhu W, Tang H, Cao L, Zhang J, Li J, Ma D, Guo C
Chemical biology & drug design 2022 Jul;100(1):108-120
Chemical biology & drug design 2022 Jul;100(1):108-120
Transcriptomic analysis and laboratory experiments reveal potential critical genes and regulatory mechanisms in sepsis-associated acute kidney injury.
Liu B, Ao S, Tan F, Ma W, Liu H, Liang H, Yang X, Chi X
Annals of translational medicine 2022 Jul;10(13):737
Annals of translational medicine 2022 Jul;10(13):737
Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway.
Chen Z, Liu H, Zhao X, Mamateli S, Liu C, Wang L, Yu J, Liu Y, Cai J, Qiao T
BMC complementary medicine and therapies 2022 Jul 7;22(1):180
BMC complementary medicine and therapies 2022 Jul 7;22(1):180
Cyclo(-Phe-Phe) alleviates chick embryo liver injury via activating the Nrf2 pathway.
Zhang QY, Han SC, Huang RP, Jiang MY, Yan CY, Li XY, Zhan YJ, Li XM, Li YF, Kurihara H, Tan RR, Li WX, He RR
Food & function 2022 Jul 4;13(13):6962-6974
Food & function 2022 Jul 4;13(13):6962-6974
Quercetin Attenuates Quinocetone-Induced Cell Apoptosis In Vitro by Activating the P38/Nrf2/HO-1 Pathway and Inhibiting the ROS/Mitochondrial Apoptotic Pathway.
Dai C, Zhang Q, Shen L, Sharma G, Jiang H, Wang Z, Shen J
Antioxidants (Basel, Switzerland) 2022 Jul 30;11(8)
Antioxidants (Basel, Switzerland) 2022 Jul 30;11(8)
The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate.
Wang P, Liu D, Yan S, Liang Y, Cui J, Guo L, Ren S, Chen P
Toxics 2022 Jul 29;10(8)
Toxics 2022 Jul 29;10(8)
Andrographolide protects bone marrow mesenchymal stem cells against glucose and serum deprivation under hypoxia via the NRF2 signaling pathway.
Sun Y, Xu H, Tan B, Yi Q, Liu H, Chen T, Xiang H, Wang R, Xie Q, Tian J, Zhu J
Stem cell research & therapy 2022 Jul 18;13(1):326
Stem cell research & therapy 2022 Jul 18;13(1):326
Oxidative injury induced by drinking water disinfection by-products dibromoacetonitrile and dichloroacetonitrile in mouse hippocampal neuronal cells: The protective effect of N-acetyl-L-cysteine.
Li F, Zhou J, Zhu X, Lu R, Ye Y, Wang S, Xing G, Shen H
Toxicology letters 2022 Jul 15;365:61-73
Toxicology letters 2022 Jul 15;365:61-73
An auto-photoacoustic melanin-based drug delivery nano-platform for self-monitoring of acute kidney injury therapy via a triple-collaborative strategy.
Zhao X, Sun J, Dong J, Guo C, Cai W, Han J, Shen H, Lv S, Zhang R
Acta biomaterialia 2022 Jul 15;147:327-341
Acta biomaterialia 2022 Jul 15;147:327-341
Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4.
Sun F, Sun Y, Zhu J, Wang X, Ji C, Zhang J, Chen S, Yu Y, Xu W, Qian H
Stem cell research & therapy 2022 Jul 15;13(1):293
Stem cell research & therapy 2022 Jul 15;13(1):293
Procyanidin B2 Alleviates Heat-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells.
Wang H, Hao W, Yang L, Li T, Zhao C, Yan P, Wei S
International journal of molecular sciences 2022 Jul 14;23(14)
International journal of molecular sciences 2022 Jul 14;23(14)
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
Yu G, Ji S, Yun Y, Cheng K, Zhang H, Jia P, Wang T, Zhang L
Journal of animal science 2022 Jul 1;100(7)
Journal of animal science 2022 Jul 1;100(7)
Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway.
Wen Y, Liu Y, Huang Q, Liu R, Liu J, Zhang F, Liu S, Jiang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153856
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153856
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response.
Yang W, Tao K, Zhang P, Chen X, Sun X, Li R
Biochemical pharmacology 2022 Jan;195:114863
Biochemical pharmacology 2022 Jan;195:114863
Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.
Lou J, Zhang H, Qi J, Xu Y, Wang X, Jiang J, Hu X, Ni L, Cai Y, Wang X, Gao W, Xiao J, Zhou K
British journal of pharmacology 2022 Jan;179(2):301-321
British journal of pharmacology 2022 Jan;179(2):301-321
Silent information regulator 1 ameliorates oxidative stress injury via PGC-1α/PPARγ-Nrf2 pathway after ischemic stroke in rat.
Zhou Y, Peng L, Li Y, Zhao Y
Brain research bulletin 2022 Jan;178:37-48
Brain research bulletin 2022 Jan;178:37-48
Sinomenine attenuates alcohol-induced acute liver injury via inhibiting oxidative stress, inflammation and apoptosis in mice.
Fan H, Tu T, Zhang X, Yang Q, Liu G, Zhang T, Bao Y, Lu Y, Dong Z, Dong J, Zhao P
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112759
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112759
Dihydroartemisinin enhances the inhibitory effect of sorafenib on HepG2 cells by inducing ferroptosis and inhibiting energy metabolism.
Cui Z, Wang H, Li S, Qin T, Shi H, Ma J, Li L, Yu G, Jiang T, Li C
Journal of pharmacological sciences 2022 Jan;148(1):73-85
Journal of pharmacological sciences 2022 Jan;148(1):73-85
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway.
Du P, Zhang X, Luo K, Li Y, Fu C, Xiao J, Xiao Q
Human & experimental toxicology 2022 Jan-Dec;41:9603271221087146
Human & experimental toxicology 2022 Jan-Dec;41:9603271221087146
Protective effects of hydroxy-α-sanshool from the pericarp of Zanthoxylum bungeanum Maxim. On D-galactose/AlCl(3)-induced Alzheimer's disease-like mice via Nrf2/HO-1 signaling pathways.
Liu Y, Meng X, Sun L, Pei K, Chen L, Zhang S, Hu M
European journal of pharmacology 2022 Jan 5;914:174691
European journal of pharmacology 2022 Jan 5;914:174691
Betulinic acid-nucleoside hybrid prevents acute alcohol -induced liver damage by promoting anti-oxidative stress and autophagy.
Zheng LY, Zou X, Wang YL, Zou M, Ma F, Wang N, Li JW, Wang MS, Hung HY, Wang Q
European journal of pharmacology 2022 Jan 5;914:174686
European journal of pharmacology 2022 Jan 5;914:174686
Synthesis and biological evaluation of novel schisanhenol derivatives as potential hepatoprotective agents.
Deng L, Cheng S, Li J, Xu X, Hao X, Fan Y, Mu S
European journal of medicinal chemistry 2022 Jan 5;227:113919
European journal of medicinal chemistry 2022 Jan 5;227:113919
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo.
Wang G, Wang Y, Yang Q, Xu C, Zheng Y, Wang L, Wu J, Zeng M, Luo M
Cell death & disease 2022 Jan 10;13(1):29
Cell death & disease 2022 Jan 10;13(1):29
Luteolin attenuated cisplatin-induced cardiac dysfunction and oxidative stress via modulation of Keap1/Nrf2 signaling pathway.
Qi Y, Fu S, Pei D, Fang Q, Xin W, Yuan X, Cao Y, Shu Q, Mi X, Luo F
Free radical research 2022 Feb;56(2):209-221
Free radical research 2022 Feb;56(2):209-221
Hydrogen sulfide alleviates apoptosis and autophagy induced by beryllium sulfate in 16HBE cells.
Liu YP, Yuan XY, Li XY, Wang Y, Sun ZB, Deng WH, Lei YD, Huang L, Jiang TY, Zhang ZH
Journal of applied toxicology : JAT 2022 Feb;42(2):230-243
Journal of applied toxicology : JAT 2022 Feb;42(2):230-243
p21 restricts influenza A virus by perturbing the viral polymerase complex and upregulating type I interferon signaling.
Ma C, Li Y, Zong Y, Velkov T, Wang C, Yang X, Zhang M, Jiang Z, Sun H, Tong Q, Sun H, Pu J, Iqbal M, Liu J, Dai C, Sun Y
PLoS pathogens 2022 Feb;18(2):e1010295
PLoS pathogens 2022 Feb;18(2):e1010295
Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway.
Dang R, Wang M, Li X, Wang H, Liu L, Wu Q, Zhao J, Ji P, Zhong L, Licinio J, Xie P
Journal of neuroinflammation 2022 Feb 7;19(1):41
Journal of neuroinflammation 2022 Feb 7;19(1):41
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, Xu Z, Zhang S, Liu B, Chen Q
Cell & bioscience 2022 Feb 25;12(1):20
Cell & bioscience 2022 Feb 25;12(1):20
18β-Glycyrrhetinic acid suppresses allergic airway inflammation through NF-κB and Nrf2/HO-1 signaling pathways in asthma mice.
Liu J, Xu Y, Yan M, Yu Y, Guo Y
Scientific reports 2022 Feb 24;12(1):3121
Scientific reports 2022 Feb 24;12(1):3121
Hydroxytyrosol Alleviates Dextran Sulfate Sodium-Induced Colitis by Modulating Inflammatory Responses, Intestinal Barrier, and Microbiome.
Wang Q, Wang C, Abdullah, Tian W, Qiu Z, Song M, Cao Y, Xiao J
Journal of agricultural and food chemistry 2022 Feb 23;70(7):2241-2252
Journal of agricultural and food chemistry 2022 Feb 23;70(7):2241-2252
Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury.
He R, Liu B, Xiong R, Geng B, Meng H, Lin W, Hao B, Zhang L, Wang W, Jiang W, Li N, Geng Q
Cell death discovery 2022 Feb 2;8(1):43
Cell death discovery 2022 Feb 2;8(1):43
Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways.
Zhang L, Zhu XZ, Badamjav R, Zhang JZ, Kou JP, Yu BY, Li F
European journal of pharmacology 2022 Feb 15;917:174748
European journal of pharmacology 2022 Feb 15;917:174748
Overexpressed mitogen-and stress-activated protein kinase 1 promotes the resistance of cytarabine in acute myeloid leukemia through brahma related gene 1-mediated upregulation of heme oxygenase-1.
Zhang S, Pan C, Shang Q, Wang W, Hu T, Liu P, Chen S, Wang J, Fang Q
European journal of pharmacology 2022 Feb 15;917:174722
European journal of pharmacology 2022 Feb 15;917:174722
Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities.
Wang W, Xiong L, Li Y, Song Z, Sun D, Li H, Chen L
Bioorganic & medicinal chemistry 2022 Feb 15;56:116627
Bioorganic & medicinal chemistry 2022 Feb 15;56:116627
Regorafenib and reactive metabolite of sunitinib activate inflammasomes: Implications for multi tyrosine kinase inhibitor-Iiduced immune related adverse events.
Kato R, Ijiri Y
Die Pharmazie 2022 Feb 1;77(2):54-58
Die Pharmazie 2022 Feb 1;77(2):54-58
Acteoside alleviates dextran sulphate sodium‑induced ulcerative colitis via regulation of the HO‑1/HMGB1 signaling pathway.
Guo W, Wang X, Liu F, Chen S, Wang S, Zhang Q, Yuan L, Du S
Molecular medicine reports 2022 Dec;26(6)
Molecular medicine reports 2022 Dec;26(6)
Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 signaling pathway.
Liu L, Shi Q, Wang K, Qian Y, Zhou L, Bellusci S, Chen C, Dong N
International immunopharmacology 2022 Dec;113(Pt A):109398
International immunopharmacology 2022 Dec;113(Pt A):109398
Probiotic-fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota.
Zhao W, Peng D, Li W, Chen S, Liu B, Huang P, Wu J, Du B, Li P
Journal of the science of food and agriculture 2022 Dec;102(15):6877-6888
Journal of the science of food and agriculture 2022 Dec;102(15):6877-6888
A multi-omic landscape of steatosis-to-NASH progression.
Xiang L, Li X, Luo Y, Zhou B, Liu Y, Li Y, Wu D, Jia L, Zhu PW, Zheng MH, Wang H, Lu Y
Life metabolism 2022 Dec;1(3):242-257
Life metabolism 2022 Dec;1(3):242-257
Hatched Eggshell Membrane Can Be a Novel Source of Antioxidant Hydrolysates to Protect against H(2)O(2)-Induced Oxidative Stress in Human Chondrocytes.
Zhu L, Ma M, Ahn DU, Guyonnet V, Wang L, Zheng Y, He Q, Xiong H, Huang X
Antioxidants (Basel, Switzerland) 2022 Dec 9;11(12)
Antioxidants (Basel, Switzerland) 2022 Dec 9;11(12)
Epigallocatechin Gallate Attenuates Gentamicin-Induced Nephrotoxicity by Suppressing Apoptosis and Ferroptosis.
Yue L, Yang YR, Ma WX, Wang HY, Fan QW, Wang YY, Li C, Wang J, Hu ZM, Wang XF, Li FH, Liu MM, Jin J, Shi C, Wen JG
Molecules (Basel, Switzerland) 2022 Dec 5;27(23)
Molecules (Basel, Switzerland) 2022 Dec 5;27(23)
Geniposidic Acid from Eucommia ulmoides Oliver Staminate Flower Tea Mitigates Cellular Oxidative Stress via Activating AKT/NRF2 Signaling.
Cheng S, Jia H, Zhang Y, Zhou J, Chen X, Wu L, Wang J
Molecules (Basel, Switzerland) 2022 Dec 5;27(23)
Molecules (Basel, Switzerland) 2022 Dec 5;27(23)
JMJD8 Functions as a Novel AKT1 Lysine Demethylase.
Wang Y, Zhang Y, Li Z, Wang J
International journal of molecular sciences 2022 Dec 27;24(1)
International journal of molecular sciences 2022 Dec 27;24(1)
Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis.
Alannan M, Fatrouni H, Trézéguet V, Dittrich-Domergue F, Moreau P, Siegfried G, Liet B, Khatib AM, Grosset CF, Badran B, Fayyad-Kazan H, Merched AJ
Cells 2022 Dec 23;12(1)
Cells 2022 Dec 23;12(1)
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
Ye H, Ma Z, Liu L, Zhang T, Han Q, Xiang Z, Xia Y, Ke Y, Guan X, Shi Q, Ataullakhanov FI, Panteleev M
ChemMedChem 2022 Dec 16;17(24):e202200317
ChemMedChem 2022 Dec 16;17(24):e202200317
Adipose-Derived Mesenchymal Stem Cells Alleviate Hypertrophic Scar by Inhibiting Bioactivity and Inducing Apoptosis in Hypertrophic Scar Fibroblasts.
Li S, Yang J, Sun J, Chen M
Cells 2022 Dec 12;11(24)
Cells 2022 Dec 12;11(24)
Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling.
Wang S, Zheng Y, Jin S, Fu Y, Liu Y
Antioxidants (Basel, Switzerland) 2022 Dec 11;11(12)
Antioxidants (Basel, Switzerland) 2022 Dec 11;11(12)
Alleviating effects of selenium on fluoride-induced testosterone synthesis disorder and reproduction toxicity in rats.
Zhao H, Zhu Y, Zhao Y, Wang T, Li H, Yang J, Cheng X, Wang J, Wang J
Ecotoxicology and environmental safety 2022 Dec 1;247:114249
Ecotoxicology and environmental safety 2022 Dec 1;247:114249
The Nrf2 inhibitor brusatol synergistically enhances the cytotoxic effect of lapatinib in HER2-positive cancers.
Tian Z, Yang Y, Wu H, Chen Y, Jia H, Zhu L, He R, Jin Y, Zhou B, Ge C, Sun Y, Yang Y
Heliyon 2022 Aug;8(8):e10410
Heliyon 2022 Aug;8(8):e10410
Dioscin alleviates Alzheimer's disease through regulating RAGE/NOX4 mediated oxidative stress and inflammation.
Guan L, Mao Z, Yang S, Wu G, Chen Y, Yin L, Qi Y, Han L, Xu L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113248
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113248
Burdock (Arctium lappa L.) leaf flavonoids rich in morin and quercetin 3-O-rhamnoside ameliorate lipopolysaccharide-induced inflammation and oxidative stress in RAW264.7 cells.
Cui J, Zong W, Zhao N, Yuan R
Food science & nutrition 2022 Aug;10(8):2718-2726
Food science & nutrition 2022 Aug;10(8):2718-2726
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Network Pharmacology Research and Dual-omic Analyses Reveal the Molecular Mechanism of Natural Product Nodosin Inhibiting Muscle-Invasive Bladder Cancer in Vitro and in Vivo.
Hao X, Fan H, Yang J, Tang J, Zhou J, Zhao Y, Huang L, Xia Y
Journal of natural products 2022 Aug 26;85(8):2006-2017
Journal of natural products 2022 Aug 26;85(8):2006-2017
Aucubin promotes bone-fracture healing via the dual effects of anti-oxidative damage and enhancing osteoblastogenesis of hBM-MSCs.
Wang K, Zhou C, Li L, Dai C, Wang Z, Zhang W, Xu J, Zhu Y, Pan Z
Stem cell research & therapy 2022 Aug 19;13(1):424
Stem cell research & therapy 2022 Aug 19;13(1):424
Cytoglobin Silencing Promotes Melanoma Malignancy but Sensitizes for Ferroptosis and Pyroptosis Therapy Response.
De Backer J, Maric D, Zuhra K, Bogaerts A, Szabo C, Vanden Berghe W, Hoogewijs D
Antioxidants (Basel, Switzerland) 2022 Aug 10;11(8)
Antioxidants (Basel, Switzerland) 2022 Aug 10;11(8)
4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury.
Peng X, Su S, Zeng J, Xie K, Yang X, Xian G, Xiao Z, Zhu P, Zheng S, Xu D, Zeng Q
Free radical biology & medicine 2022 Aug 1;188:404-418
Free radical biology & medicine 2022 Aug 1;188:404-418
New mechanism of nephrotoxicity of triptolide: Oxidative stress promotes cGAS-STING signaling pathway.
Lu J, Zhang Y, Dong H, Sun J, Zhu L, Liu P, Wen F, Lin R
Free radical biology & medicine 2022 Aug 1;188:26-34
Free radical biology & medicine 2022 Aug 1;188:26-34
Fermented noni (Morinda citrifolia L.) fruit juice improved oxidative stress and insulin resistance under the synergistic effect of Nrf2/ARE pathway and gut flora in db/db mice and HepG2 cells.
Zhang X, Zhang B, Li L, Li X, Zhang J, Chen G
Food & function 2022 Aug 1;13(15):8254-8273
Food & function 2022 Aug 1;13(15):8254-8273
Evaluation of HZX-960, a novel DCN1-UBC12 interaction inhibitor, as a potential antifibrotic compound for liver fibrosis.
Zhou W, Dong G, Gao G, He Z, Xu J, Aziz S, Ma L, Zhao W
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Aug 1;100(4):309-324
Biochemistry and cell biology = Biochimie et biologie cellulaire 2022 Aug 1;100(4):309-324
N-acetylcysteine promotes cyclic mechanical stress-induced osteogenic differentiation of periodontal ligament stem cells by down-regulating Nrf2 expression.
Xi X, Li ZX, Zhao Y, Liu H, Chen S, Liu DX
Journal of dental sciences 2022 Apr;17(2):750-762
Journal of dental sciences 2022 Apr;17(2):750-762
Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
Zhu W, Tang H, Li J, Guedes RM, Cao L, Guo C
Bioengineered 2022 Apr;13(4):9233-9247
Bioengineered 2022 Apr;13(4):9233-9247
Neuron derived fractalkine promotes microglia to absorb hematoma via CD163/HO-1 after intracerebral hemorrhage.
You M, Long C, Wan Y, Guo H, Shen J, Li M, He Q, Hu B
Cellular and molecular life sciences : CMLS 2022 Apr 7;79(5):224
Cellular and molecular life sciences : CMLS 2022 Apr 7;79(5):224
Novel oral edaravone attenuates diastolic dysfunction of diabetic cardiomyopathy by activating the Nrf2 signaling pathway.
Wang L, Zeng YQ, Gu JH, Song R, Cang PH, Xu YX, Shao XX, Pu LJ, Luo HY, Zhou XF
European journal of pharmacology 2022 Apr 5;920:174846
European journal of pharmacology 2022 Apr 5;920:174846
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels.
Han Y, Li C, Zhang P, Yang X, Min J, Wu Q, Xie Y, Jin D, Wang Z, Shao F, Quan H
European journal of pharmacology 2022 Apr 5;920:174811
European journal of pharmacology 2022 Apr 5;920:174811
miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia-reperfusion injury in steatotic grafts.
Wu L, Tian X, Zuo H, Zheng W, Li X, Yuan M, Tian X, Song H
Journal of nanobiotechnology 2022 Apr 22;20(1):196
Journal of nanobiotechnology 2022 Apr 22;20(1):196
Relationship between Neuroprotective Effects and Structure of Procyanidins.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Apr 2;27(7)
Molecules (Basel, Switzerland) 2022 Apr 2;27(7)
MFG-E8 alleviates intervertebral disc degeneration by suppressing pyroptosis and extracellular matrix degradation in nucleus pulposus cells via Nrf2/TXNIP/NLRP3 axis.
Ma H, Xie C, Chen Z, He G, Dai Z, Cai H, Zhang H, Lu H, Wu H, Hu X, Zhou K, Zheng G, Xu H, Xu C
Cell death discovery 2022 Apr 19;8(1):209
Cell death discovery 2022 Apr 19;8(1):209
Chronic exposure to propylparaben at the humanly relevant dose triggers ovarian aging in adult mice.
Yan W, Li M, Guo Q, Li X, Zhou S, Dai J, Zhang J, Wu M, Tang W, Wen J, Xue L, Jin Y, Luo A, Wang S
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Ecotoxicology and environmental safety 2022 Apr 15;235:113432
Trehalose inhibits ferroptosis via NRF2/HO-1 pathway and promotes functional recovery in mice with spinal cord injury.
Gong F, Ge T, Liu J, Xiao J, Wu X, Wang H, Zhu Y, Xia D, Hu B
Aging 2022 Apr 10;14(7):3216-3232
Aging 2022 Apr 10;14(7):3216-3232
Role of caspase-8 and/or -9 as biomarkers that can distinguish the potential to cause toxic- and immune related-adverse event, for the progress of acetaminophen-induced liver injury.
Noda T, Kato R, Hattori T, Furukawa Y, Ijiri Y, Tanaka K
Life sciences 2022 Apr 1;294:120351
Life sciences 2022 Apr 1;294:120351
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Xi X, Li Z, Liu H, Chen S, Liu D
Frontiers in cell and developmental biology 2021;9:816000
Frontiers in cell and developmental biology 2021;9:816000
Notoginsenoside R1 Protects Against High Glucose-Induced Cell Injury Through AMPK/Nrf2 and Downstream HO-1 Signaling.
Du F, Huang H, Cao Y, Ran Y, Wu Q, Chen B
Frontiers in cell and developmental biology 2021;9:791643
Frontiers in cell and developmental biology 2021;9:791643
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Liao ZQ, Jiang YN, Su ZL, Bi HL, Li JT, Li CL, Yang XL, Zhang Y, Xie X
Frontiers in cardiovascular medicine 2021;8:809689
Frontiers in cardiovascular medicine 2021;8:809689
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Wu X, Zhang T, Lyu P, Chen M, Ni G, Cheng H, Xu G, Li X, Wang L, Shang H
Frontiers in cardiovascular medicine 2021;8:698056
Frontiers in cardiovascular medicine 2021;8:698056
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695
Frontiers in nutrition 2021;8:667695
Immunoresponsive gene 1 modulates the severity of brain injury in cerebral ischaemia.
Kuo PC, Weng WT, Scofield BA, Furnas D, Paraiso HC, Yu IC, Yen JH
Brain communications 2021;3(3):fcab187
Brain communications 2021;3(3):fcab187
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway.
Lu Y, Zhang W, Zhang B, Heinemann SH, Hoshi T, Hou S, Zhang G
Oxidative medicine and cellular longevity 2021;2021:8869908
Oxidative medicine and cellular longevity 2021;2021:8869908
Gastrodin Promotes the Survival of Random-Pattern Skin Flaps via Autophagy Flux Stimulation.
Chen H, Chen B, Li B, Luo X, Wu H, Zhang C, Liu J, Jiang J, Zhao B
Oxidative medicine and cellular longevity 2021;2021:6611668
Oxidative medicine and cellular longevity 2021;2021:6611668
Liraglutide, a TFEB-Mediated Autophagy Agonist, Promotes the Viability of Random-Pattern Skin Flaps.
Zhu X, Hu X, Lou J, Li J, Xu Y, Yu G, Wu C, Ding J, Gao W, Xiao J, Zhou K, Jia C
Oxidative medicine and cellular longevity 2021;2021:6610603
Oxidative medicine and cellular longevity 2021;2021:6610603
GPX4-Regulated Ferroptosis Mediates S100-Induced Experimental Autoimmune Hepatitis Associated with the Nrf2/HO-1 Signaling Pathway.
Zhu L, Chen D, Zhu Y, Pan T, Xia D, Cai T, Lin H, Lin J, Jin X, Wu F, Yu S, Zhu K, Xu L, Chen Y
Oxidative medicine and cellular longevity 2021;2021:6551069
Oxidative medicine and cellular longevity 2021;2021:6551069
DCA Protects against Oxidation Injury Attributed to Cerebral Ischemia-Reperfusion by Regulating Glycolysis through PDK2-PDH-Nrf2 Axis.
Zhao X, Li S, Mo Y, Li R, Huang S, Zhang A, Ni X, Dai Q, Wang J
Oxidative medicine and cellular longevity 2021;2021:5173035
Oxidative medicine and cellular longevity 2021;2021:5173035
Protective Effect of Uric Acid on ox-LDL-Induced HUVECs Injury via Keap1-Nrf2-ARE Pathway.
Lin Y, Xie Y, Hao Z, Bi H, Liu Y, Yang X, Xia Y
Journal of immunology research 2021;2021:5151168
Journal of immunology research 2021;2021:5151168
Buyang Huanwu Decoction Enhances Revascularization via Akt/GSK3β/NRF2 Pathway in Diabetic Hindlimb Ischemia.
Bao XY, Deng LH, Huang ZJ, Daror AS, Wang ZH, Jin WJ, Zhuang Z, Tong Q, Zheng GQ, Wang Y
Oxidative medicine and cellular longevity 2021;2021:1470829
Oxidative medicine and cellular longevity 2021;2021:1470829
Gastric Electrical Pacing Reduces Apoptosis of Interstitial Cells of Cajal via Antioxidative Stress Effect Attributing to Phenotypic Polarization of M2 Macrophages in Diabetic Rats.
Wang H, Zhao K, Ba Y, Gao T, Shi N, Niu Q, Liu C, Chen Y
Oxidative medicine and cellular longevity 2021;2021:1298657
Oxidative medicine and cellular longevity 2021;2021:1298657
Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies.
Zou L, Cheng G, Xu C, Liu H, Wang Y, Li N, Fan X, Zhu C, Xia W
International journal of nanomedicine 2021;16:1565-1573
International journal of nanomedicine 2021;16:1565-1573
Methylcobalamin Protects Melanocytes from H(2)O(2)-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway.
An R, Li D, Dong Y, She Q, Zhou T, Nie X, Pan R, Deng Y
Drug design, development and therapy 2021;15:4837-4848
Drug design, development and therapy 2021;15:4837-4848
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug design, development and therapy 2021;15:3207-3221
Drug design, development and therapy 2021;15:3207-3221
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Wang H, Jiang Z, Pang Z, Qi G, Hua B, Yan Z, Yuan H
Journal of inflammation research 2021;14:745-760
Journal of inflammation research 2021;14:745-760
Curcumin promotes the survival of ischemic random skin flaps via autophagy.
Tu Z, Jiang X, Li Y, Yang S, Lin D, Shi Y, Mao C, Zhang X, Lin C
American journal of translational research 2021;13(3):1337-1351
American journal of translational research 2021;13(3):1337-1351
DPHC From Alpinia officinarum Ameliorates Oxidative Stress and Insulin Resistance via Activation of Nrf2/ARE Pathway in db/db Mice and High Glucose-Treated HepG2 Cells.
Zhang X, Zhang Y, Zhou M, Xie Y, Dong X, Bai F, Zhang J
Frontiers in pharmacology 2021;12:792977
Frontiers in pharmacology 2021;12:792977
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Zheng T, Yang J, Zhang J, Yang C, Fan Z, Li Q, Zhai Y, Liu H, Yang J
Frontiers in pharmacology 2021;12:669146
Frontiers in pharmacology 2021;12:669146
Pseudoginsenoside F11 Enhances the Viability of Random-Pattern Skin Flaps by Promoting TFEB Nuclear Translocation Through AMPK-mTOR Signal Pathway.
Zhou F, Zhang X, Jiang L, Li S, Chen Y, Wu J
Frontiers in pharmacology 2021;12:667524
Frontiers in pharmacology 2021;12:667524
4-OI Attenuates Carbon Tetrachloride-Induced Hepatic Injury via Regulating Oxidative Stress and the Inflammatory Response.
Li R, Yang W, Yin Y, Ma X, Zhang P, Tao K
Frontiers in pharmacology 2021;12:651444
Frontiers in pharmacology 2021;12:651444
Antioxidant activity of mesenchymal stem cell-derived extracellular vesicles restores hippocampal neurons following seizure damage.
Luo Q, Xian P, Wang T, Wu S, Sun T, Wang W, Wang B, Yang H, Yang Y, Wang H, Liu W, Long Q
Theranostics 2021;11(12):5986-6005
Theranostics 2021;11(12):5986-6005
Proteome Analysis of Camellia nitidissima Chi Revealed Its Role in Colon Cancer Through the Apoptosis and Ferroptosis Pathway.
Chen Y, Zhang F, Du Z, Xie J, Xia L, Hou X, Hao E, Deng J
Frontiers in oncology 2021;11:727130
Frontiers in oncology 2021;11:727130
Polydatin has anti-inflammatory and antioxidant effects in LPS-induced macrophages and improves DSS-induced mice colitis.
Chen G, Yang Z, Wen D, Guo J, Xiong Q, Li P, Zhao L, Wang J, Wu C, Dong L
Immunity, inflammation and disease 2021 Sep;9(3):959-970
Immunity, inflammation and disease 2021 Sep;9(3):959-970
Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats.
Kong Y, Li S, Zhang M, Xu W, Chen Q, Zheng L, Liu P, Zou W
Journal of molecular neuroscience : MN 2021 Sep;71(9):1863-1875
Journal of molecular neuroscience : MN 2021 Sep;71(9):1863-1875
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Ren F, Xu X, Xu J, Mei Y, Zhang J, Wang X, Li F
Environmental toxicology 2021 Sep;36(9):1765-1774
Environmental toxicology 2021 Sep;36(9):1765-1774
N2L, a novel lipoic acid-niacin dimer, attenuates ferroptosis and decreases lipid peroxidation in HT22 cells.
Peng W, Zhu Z, Yang Y, Hou J, Lu J, Chen C, Liu F, Pi R
Brain research bulletin 2021 Sep;174:250-259
Brain research bulletin 2021 Sep;174:250-259
Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance.
Cui M, Atmanli A, Morales MG, Tan W, Chen K, Xiao X, Xu L, Liu N, Bassel-Duby R, Olson EN
Nature communications 2021 Sep 6;12(1):5270
Nature communications 2021 Sep 6;12(1):5270
Nano chitosan-zinc complex improves the growth performance and antioxidant capacity of the small intestine in weaned piglets.
Zhang M, Hou G, Hu P, Feng D, Wang J, Zhu W
The British journal of nutrition 2021 Sep 28;126(6):801-812
The British journal of nutrition 2021 Sep 28;126(6):801-812
Protective effects of dioscin against isoproterenol-induced cardiac hypertrophy via adjusting PKCε/ERK-mediated oxidative stress.
Li R, Qi Y, Yuan Q, Xu L, Gao M, Xu Y, Han X, Yin L, Liu C
European journal of pharmacology 2021 Sep 15;907:174277
European journal of pharmacology 2021 Sep 15;907:174277
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Zhang Q, Su G, Yang Q, Wei Z, Wang J, Zheng L, Zhao M
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
Wen L, Yang QH, Ma XL, Li T, Xiao S, Sun CF
International immunopharmacology 2021 Oct;99:107993
International immunopharmacology 2021 Oct;99:107993
Thymus quinquecostatus Celak. ameliorates cerebral ischemia-reperfusion injury via dual antioxidant actions: Activating Keap1/Nrf2/HO-1 signaling pathway and directly scavenging ROS.
Fan S, Liu X, Wang Y, Ren X, Liu Y, Dong Y, Fan Q, Wei J, Ma J, Yu A, Song R, Sui H, Shen M, Fang F, Xia Q, She G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153673
Oxidation of Hemoglobin Drives a Proatherogenic Polarization of Macrophages in Human Atherosclerosis.
Potor L, Hendrik Z, Patsalos A, Katona É, Méhes G, Póliska S, Csősz É, Kalló G, Komáromi I, Combi Z, Posta N, Sikura KÉ, Pethő D, Oros M, Vereb G, Tóth C, Gergely P, Nagy L, Balla G, Balla J
Antioxidants & redox signaling 2021 Oct 20;35(12):917-950
Antioxidants & redox signaling 2021 Oct 20;35(12):917-950
The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway.
Guo X, Cao P, Lian X, Hu M, Zhao J, Shen W, Wang H, Yu H, Chen Y
European journal of pharmacology 2021 Oct 15;909:174439
European journal of pharmacology 2021 Oct 15;909:174439
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury.
Kong L, Deng J, Zhou X, Cai B, Zhang B, Chen X, Chen Z, Wang W
Cell death & disease 2021 Oct 11;12(10):928
Cell death & disease 2021 Oct 11;12(10):928
Effects of Bacillus subtilis on jejunal integrity, redox status, and microbial composition of intrauterine growth restriction suckling piglets.
Yun Y, Ji S, Yu G, Jia P, Niu Y, Zhang H, Zhang X, Wang T, Zhang L
Journal of animal science 2021 Oct 1;99(10)
Journal of animal science 2021 Oct 1;99(10)
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Epigallocatechin gallate and theaflavins independently alleviate cyclophosphamide-induced ovarian damage by inhibiting the overactivation of primordial follicles and follicular atresia.
Chen Q, Xu Z, Li X, Du D, Wu T, Zhou S, Yan W, Wu M, Jin Y, Zhang J, Wang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153752
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Nov;92:153752
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells.
Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, Birsoy K
Nature 2021 Nov;599(7883):136-140
Nature 2021 Nov;599(7883):136-140
HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.
He R, Wang Z, Cui M, Liu S, Wu W, Chen M, Wu Y, Qu Y, Lin H, Chen S, Wang B, Shao Z
Autophagy 2021 Nov;17(11):3338-3360
Autophagy 2021 Nov;17(11):3338-3360
Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo.
Liu Y, Zhou J, Luo Y, Li J, Shang L, Zhou F, Yang S
Chinese medicine 2021 Nov 29;16(1):127
Chinese medicine 2021 Nov 29;16(1):127
Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization.
Feng J, Liu Z, Chen H, Zhang M, Ma X, Han Q, Lu D, Wang C
European journal of pharmacology 2021 Nov 15;911:174522
European journal of pharmacology 2021 Nov 15;911:174522
Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.
Chen Y, Wang J, Li J, Zhu J, Wang R, Xi Q, Wu H, Shi T, Chen W
European journal of pharmacology 2021 Nov 15;911:174518
European journal of pharmacology 2021 Nov 15;911:174518
Si-Wu-Tang facilitates ovarian function through improving ovarian microenvironment and angiogenesis in a mouse model of premature ovarian failure.
Zhou F, Song Y, Liu X, Zhang C, Li F, Hu R, Huang Y, Ma W, Song K, Zhang M
Journal of ethnopharmacology 2021 Nov 15;280:114431
Journal of ethnopharmacology 2021 Nov 15;280:114431
An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury.
Mu X, Wang J, He H, Li Q, Yang B, Wang J, Liu H, Gao Y, Ouyang L, Sun S, Ren Q, Shi X, Hao W, Fei Q, Yang J, Li L, Vest R, Wyss-Coray T, Luo J, Zhang XD
Science advances 2021 Nov 12;7(46):eabk1210
Science advances 2021 Nov 12;7(46):eabk1210
Dexmedetomidine ameliorates endotoxin-induced acute lung injury in vivo and in vitro by preserving mitochondrial dynamic equilibrium through the HIF-1a/HO-1 signaling pathway.
Shi J, Yu T, Song K, Du S, He S, Hu X, Li X, Li H, Dong S, Zhang Y, Xie Z, Li C, Yu J
Redox biology 2021 May;41:101954
Redox biology 2021 May;41:101954
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Li J, Chen H, Lou J, Bao G, Wu C, Lou Z, Wang X, Ding J, Li Z, Xiao J, Xu H, Gao W, Zhou K
Journal of cellular physiology 2021 May;236(5):3641-3659
Journal of cellular physiology 2021 May;236(5):3641-3659
Protective effects of gastrodin pretreatment on mouse hepatic ischemia-reperfusion occurring through antioxidant and anti-apoptotic mechanisms.
Sun B, Jiang J, Zhu X, Yang D, Cui Z, Zhang Y, Zhang M, Qian Y, Liu R, Yang W
Experimental and therapeutic medicine 2021 May;21(5):471
Experimental and therapeutic medicine 2021 May;21(5):471
Development of phenyltriazole thiol-based derivatives as highly potent inhibitors of DCN1-UBC12 interaction.
Zhou W, Xu C, Dong G, Qiao H, Yang J, Liu H, Ding L, Sun K, Zhao W
European journal of medicinal chemistry 2021 May 5;217:113326
European journal of medicinal chemistry 2021 May 5;217:113326
Autophagy deficiency exacerbates acute lung injury induced by copper oxide nanoparticles.
Xiao J, Tu B, Zhou X, Jiang X, Xu G, Zhang J, Qin X, Sumayyah G, Fan J, Wang B, Chen C, Zou Z
Journal of nanobiotechnology 2021 May 31;19(1):162
Journal of nanobiotechnology 2021 May 31;19(1):162
Neuroprotective Effects and Mechanisms of Procyanidins In Vitro and In Vivo.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D
Molecules (Basel, Switzerland) 2021 May 17;26(10)
Molecules (Basel, Switzerland) 2021 May 17;26(10)
4-Ethylguaiacol modulates neuroinflammation and Th1/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis.
Weng WT, Kuo PC, Brown DA, Scofield BA, Furnas D, Paraiso HC, Wang PY, Yu IC, Yen JH
Journal of neuroinflammation 2021 May 11;18(1):110
Journal of neuroinflammation 2021 May 11;18(1):110
In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit.
Feng XH, Xu HY, Wang JY, Duan S, Wang YC, Ma CM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153479
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress.
Wang BN, Wu CB, Chen ZM, Zheng PP, Liu YQ, Xiong J, Xu JY, Li PF, Mamun AA, Ye LB, Zheng ZL, Wu YQ, Xiao J, Wang J
Acta pharmacologica Sinica 2021 Mar;42(3):347-360
Acta pharmacologica Sinica 2021 Mar;42(3):347-360
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Chondrocyte ferroptosis contribute to the progression of osteoarthritis.
Yao X, Sun K, Yu S, Luo J, Guo J, Lin J, Wang G, Guo Z, Ye Y, Guo F
Journal of orthopaedic translation 2021 Mar;27:33-43
Journal of orthopaedic translation 2021 Mar;27:33-43
Polyphenols from Penthorum chinense Pursh. Attenuates high glucose-induced vascular inflammation through directly interacting with Keap1 protein.
Sun Y, He L, Wang W, Wang T, Hua W, Li T, Wang L, Gao T, Chen F, Tang L
Journal of ethnopharmacology 2021 Mar 25;268:113617
Journal of ethnopharmacology 2021 Mar 25;268:113617
FGF1(ΔHBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Wang D, Yin Y, Wang S, Zhao T, Gong F, Zhao Y, Wang B, Huang Y, Cheng Z, Zhu G, Wang Z, Wang Y, Ren J, Liang G, Li X, Huang Z
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Signal transduction and targeted therapy 2021 Mar 24;6(1):133
Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.
Wang W, Zhai D, Bai Y, Xue K, Deng L, Ma L, Du T, Ye Z, Qu D, Xiang A, Chen G, Zhao Y, Wang L, Lu Z
Cell death discovery 2021 Mar 23;7(1):58
Cell death discovery 2021 Mar 23;7(1):58
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X, Zhang X
Food & function 2021 Mar 21;12(6):2703-2714
Food & function 2021 Mar 21;12(6):2703-2714
Contributions of HO-1-Dependent MAPK to Regulating Intestinal Barrier Disruption.
Zhang Z, Zhang Q, Li F, Xin Y, Duan Z
Biomolecules & therapeutics 2021 Mar 1;29(2):175-183
Biomolecules & therapeutics 2021 Mar 1;29(2):175-183
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Lu D, Le Y, Ding J, Dou X, Mao W, Zhu J
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Cell biochemistry and biophysics 2021 Jun;79(2):239-252
Improving protection effects of eucalyptol via carboxymethyl chitosan-coated lipid nanoparticles on hyperglycaemia-induced vascular endothelial injury in rats.
Peng J, Jiang Z, Wu G, Cai Z, Du Q, Tao L, Zhang Y, Chen Y, Shen X
Journal of drug targeting 2021 Jun;29(5):520-530
Journal of drug targeting 2021 Jun;29(5):520-530
Synthesis and radioprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opening derivatives.
Li X, Wang X, Miao L, Liu Y, Lin X, Guo Y, Yuan R, Tian H
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Journal of cellular and molecular medicine 2021 Jun;25(12):5470-5485
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Zhang Z, Qin X, Wang Z, Li Y, Chen F, Chen R, Li C, Zhang W, Zhang M
Experimental and therapeutic medicine 2021 Jun;21(6):556
Experimental and therapeutic medicine 2021 Jun;21(6):556
The nephroprotective effects and mechanisms of rehmapicrogenin include ROS inhibition via an oestrogen-like pathway both in vivo and in vitro.
Wang M, Ke Y, Li Y, Shan Z, Mi W, Cao Y, Feng W, Zheng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111305
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111305
Design, synthesis, and neuroprotective effects of novel hybrid compounds containing edaravone analogue and 3-n-butylphthalide ring-opened derivatives.
Li X, Wang X, Miao L, Guo Y, Yuan R, Tian H
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Biochemical and biophysical research communications 2021 Jun 4;556:99-105
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Pan H, Xu Y, Cai Q, Wu M, Ding M
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis.
Liu Z, He Q, Liu Y, Zhang Y, Cui M, Peng H, Wang Y, Chen S, Li D, Chen L, Xiao Y, Chen W, Wang Q
Toxicology 2021 Jun 30;458:152838
Toxicology 2021 Jun 30;458:152838
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury.
Dai C, Li H, Wang Y, Tang S, Velkov T, Shen J
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 18;10(6)
Nrf2 activation is involved in osteogenic differentiation of periodontal ligament stem cells under cyclic mechanical stretch.
Xi X, Zhao Y, Liu H, Li Z, Chen S, Liu D
Experimental cell research 2021 Jun 15;403(2):112598
Experimental cell research 2021 Jun 15;403(2):112598
Protective effect of scorpion venom heat-resistant synthetic peptide against PM(2.5)-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-κB signaling pathway.
Xu X, Xu H, Ren F, Huang L, Xu J, Li F
Journal of neuroimmunology 2021 Jun 15;355:577567
Journal of neuroimmunology 2021 Jun 15;355:577567
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling.
Liu X, Li M, Zhu J, Huang W, Song J
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Human & experimental toxicology 2021 Jul;40(7):1095-1111
Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis.
Liu P, Li J, Liu M, Zhang M, Xue Y, Zhang Y, Han X, Jing X, Chu L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111552
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jul;139:111552
Baicalin-loaded macrophage-derived exosomes ameliorate ischemic brain injury via the antioxidative pathway.
Huang Z, Guo L, Huang L, Shi Y, Liang J, Zhao L
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
Materials science & engineering. C, Materials for biological applications 2021 Jul;126:112123
A novel PGAM5 inhibitor LFHP-1c protects blood-brain barrier integrity in ischemic stroke.
Gao C, Xu Y, Liang Z, Wang Y, Shang Q, Zhang S, Wang C, Ni M, Wu D, Huang Z, Pang T
Acta pharmaceutica Sinica. B 2021 Jul;11(7):1867-1884
Acta pharmaceutica Sinica. B 2021 Jul;11(7):1867-1884
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
Wu M, Chen W, Miao M, Jin Q, Zhang S, Bai M, Fan J, Zhang Y, Zhang A, Jia Z, Huang S
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, Yang W, Mai Y, Liu R, Chen M, Dai C, Yang H, Lu J, Li H, Guan G, Huang M, Liu P, Li Z
Cell death & disease 2021 Jul 26;12(8):738
Cell death & disease 2021 Jul 26;12(8):738
Proteomics analysis in the kidney of mice following oral feeding Realgar.
Zhang S, Li C, Feng T, Cao S, Zhou H, Li L, Hu Q, Mao X, Ji S
Journal of ethnopharmacology 2021 Jul 15;275:114118
Journal of ethnopharmacology 2021 Jul 15;275:114118
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury.
Guo L, Zhang T, Wang F, Chen X, Xu H, Zhou C, Chen M, Yu F, Wang S, Yang D, Wu B
British journal of pharmacology 2021 Jan;178(2):328-345
British journal of pharmacology 2021 Jan;178(2):328-345
CKIP-1 acts downstream to Cx43 on the activation of Nrf2 signaling pathway to protect from renal fibrosis in diabetes.
Yang Y, Li J, Zhang L, Lin Z, Xiao H, Sun X, Zhang M, Liu P, Huang H
Pharmacological research 2021 Jan;163:105333
Pharmacological research 2021 Jan;163:105333
Polydatin mitigates pancreatic β-cell damage through its antioxidant activity.
Yousef AI, Shawki HH, El-Shahawy AA, El-Twab SMA, Abdel-Moneim A, Oishi H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111027
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111027
Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells.
Zhu XG, Chudnovskiy A, Baudrier L, Prizer B, Liu Y, Ostendorf BN, Yamaguchi N, Arab A, Tavora B, Timson R, Heissel S, de Stanchina E, Molina H, Victora GD, Goodarzi H, Birsoy K
Cell metabolism 2021 Jan 5;33(1):211-221.e6
Cell metabolism 2021 Jan 5;33(1):211-221.e6
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Lv H, Sun X, Jia H, Xu C
Food & function 2021 Jan 21;12(2):696-705
Food & function 2021 Jan 21;12(2):696-705
Xanthatin synergizes with cisplatin to suppress homologous recombination through JAK2/STAT4/BARD1 axis in human NSCLC cells.
Zhang J, Yang S, Guan H, Zhou J, Gao Y
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Journal of cellular and molecular medicine 2021 Feb;25(3):1688-1699
Marine algal polysaccharides alleviate aflatoxin B1-induced bursa of Fabricius injury by regulating redox and apoptotic signaling pathway in broilers.
Guo Y, Balasubramanian B, Zhao ZH, Liu WC
Poultry science 2021 Feb;100(2):844-857
Poultry science 2021 Feb;100(2):844-857
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Wang Z, Cai B, Cao C, Lv H, Dai Y, Zheng M, Zhao G, Peng Y, Gou W, Wang J, Liu D, Hu Y
Free radical biology & medicine 2021 Feb 20;164:249-257
Free radical biology & medicine 2021 Feb 20;164:249-257
Phytochemical characterization and hepatoprotective effect of active fragment from Adhatoda vasica Nees. against tert-butyl hydroperoxide induced oxidative impairment via activating AMPK/p62/Nrf2 pathway.
Lu Q, Gu W, Luo C, Wang L, Hua W, Sun Y, Tang L
Journal of ethnopharmacology 2021 Feb 10;266:113454
Journal of ethnopharmacology 2021 Feb 10;266:113454
Prenylated xanthones from mangosteen (Garcinia mangostana) activate the AhR and Nrf2 pathways and protect intestinal barrier integrity in HT-29 cells.
Tocmo R, Le B, Heun A, van Pijkeren JP, Parkin K, Johnson JJ
Free radical biology & medicine 2021 Feb 1;163:102-115
Free radical biology & medicine 2021 Feb 1;163:102-115
Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis.
Yang RZ, Zheng HL, Xu WN, Zheng XF, Li B, Jiang LS, Jiang SD
Aging 2021 Feb 1;13(3):4647-4662
Aging 2021 Feb 1;13(3):4647-4662
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Feng Z, Wang C, Yue, Jin, Meng Q, Wu J, Sun H
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Pharmaceutical biology 2021 Dec;59(1):1106-1116
CoCrMo-Nanoparticles induced peri-implant osteolysis by promoting osteoblast ferroptosis via regulating Nrf2-ARE signalling pathway.
Xu Y, Sang W, Zhong Y, Xue S, Yang M, Wang C, Lu H, Huan R, Mao X, Zhu L, He C, Ma J
Cell proliferation 2021 Dec;54(12):e13142
Cell proliferation 2021 Dec;54(12):e13142
ChREBP deficiency alleviates apoptosis by inhibiting TXNIP/oxidative stress in diabetic nephropathy.
Chen N, Song S, Yang Z, Wu M, Mu L, Zhou T, Shi Y
Journal of diabetes and its complications 2021 Dec;35(12):108050
Journal of diabetes and its complications 2021 Dec;35(12):108050
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Song Z, Gao C, Jiang Q, Xu J, Xiong L, Liu K, Sun D, Li H, Chen L
Phytochemistry 2021 Dec;192:112971
Phytochemistry 2021 Dec;192:112971
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Bao S, Zheng H, Chen C, Zhang Y, Bao L, Yang B, Hou Y, Chen Y, Zhang Q, Pi J, Fu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells.
Tong J, Fang J, Zhu T, Xiang P, Shang J, Chen L, Zhao J, Wang Y, Tong L, Sun M
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Journal of pharmacological sciences 2021 Dec;147(4):305-314
Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway.
Li Y, Guo L, Hou Z, Gong H, Yan M, Zhang B
Journal of ethnopharmacology 2021 Dec 5;281:114489
Journal of ethnopharmacology 2021 Dec 5;281:114489
Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation.
Lei I, Tian S, Gao W, Liu L, Guo Y, Tang P, Chen E, Wang Z
eLife 2021 Dec 23;10
eLife 2021 Dec 23;10
Exposure to DEHP induces testis toxicity and injury through the ROS/mTOR/NLRP3 signaling pathway in immature rats.
Hong Y, Zhou Y, Shen L, Wei Y, Long C, Fu Y, Wu H, Wang J, Wu Y, Wu S, Wei G
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
Ecotoxicology and environmental safety 2021 Dec 20;227:112889
Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway.
Cao L, Zhao J, Ma L, Chen J, Xu J, Rahman SU, Feng S, Li Y, Wu J, Wang X
Ecotoxicology and environmental safety 2021 Dec 1;225:112737
Ecotoxicology and environmental safety 2021 Dec 1;225:112737
Design, synthesis, and evaluation of mono-carbonyl analogues of curcumin (MCACs) as potential antioxidants against periodontitis.
Zhao Y, Zheng Z, Zhang M, Wang Y, Hu R, Lin W, Huang C, Xu C, Wu J, Deng H
Journal of periodontal research 2021 Aug;56(4):656-666
Journal of periodontal research 2021 Aug;56(4):656-666
The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy.
Tan Y, Cao H, Li Q, Sun J
Cell biology international 2021 Aug;45(8):1654-1665
Cell biology international 2021 Aug;45(8):1654-1665
Pulmonary Exposure to Copper Oxide Nanoparticles Leads to Neurotoxicity via Oxidative Damage and Mitochondrial Dysfunction.
Zhou H, Yao L, Jiang X, Sumayyah G, Tu B, Cheng S, Qin X, Zhang J, Zou Z, Chen C
Neurotoxicity research 2021 Aug;39(4):1160-1170
Neurotoxicity research 2021 Aug;39(4):1160-1170
CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.
Hou X, Liu H, Ping Y, Zhang F, Zhi L, Jiang X, Zhang F, Song C, Zhang Z, Song J
Brain research bulletin 2021 Aug;173:74-81
Brain research bulletin 2021 Aug;173:74-81
The in vitro and in vivo study of oleanolic acid indole derivatives as novel anti-inflammatory agents: Synthesis, biological evaluation, and mechanistic analysis.
Jin J, He H, Zhang X, Wu R, Gan L, Li D, Lu Y, Wu P, Wong WL, Zhang K
Bioorganic chemistry 2021 Aug;113:104981
Bioorganic chemistry 2021 Aug;113:104981
Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway.
Huang Q, Ouyang DS, Liu Q
FEBS open bio 2021 Aug;11(8):2350-2363
FEBS open bio 2021 Aug;11(8):2350-2363
Aloe polysaccharides ameliorate acute colitis in mice via Nrf2/HO-1 signaling pathway and short-chain fatty acids metabolism.
Liu C, Hua H, Zhu H, Cheng Y, Guo Y, Yao W, Qian H
International journal of biological macromolecules 2021 Aug 31;185:804-812
International journal of biological macromolecules 2021 Aug 31;185:804-812
The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl(4)-induced liver injury in vivo.
Xin C, Liu S, Qu H, Wang Z
International journal of biological macromolecules 2021 Aug 31;185:338-349
International journal of biological macromolecules 2021 Aug 31;185:338-349
Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway.
Zhao Y, Lu J, Mao A, Zhang R, Guan S
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Journal of agricultural and food chemistry 2021 Aug 25;69(33):9671-9683
Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease.
Yang X, Chen A, Liang Q, Dong Q, Fu M, Liu X, Wang S, Li Y, Ye Y, Lan Z, Ou JS, Lu L, Yan J
Free radical biology & medicine 2021 Aug 20;172:530-540
Free radical biology & medicine 2021 Aug 20;172:530-540
A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis.
Lu R, Jiang Y, Lai X, Liu S, Sun L, Zhou ZW
International journal of molecular sciences 2021 Aug 18;22(16)
International journal of molecular sciences 2021 Aug 18;22(16)
Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.
Kato R, Ijiri Y, Hayashi T
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865
Virtual screening identified natural Keap1-Nrf2 PPI inhibitor alleviates inflammatory osteoporosis through Nrf2-mir214-Traf3 axis.
Hong J, Shi Z, Li C, Ji X, Li S, Chen Y, Jiang G, Shi M, Wang W, Zhang Y, Hu B, Yan S
Free radical biology & medicine 2021 Aug 1;171:365-378
Free radical biology & medicine 2021 Aug 1;171:365-378
Myricetin protects against H(2) O(2) -induced oxidative damage and apoptosis in bovine mammary epithelial cells.
Kan X, Liu J, Chen Y, Guo W, Xu D, Cheng J, Cao Y, Yang Z, Fu S
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Journal of cellular physiology 2021 Apr;236(4):2684-2695
Adenosine 5'-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Journal of dairy science 2021 Apr;104(4):4516-4528
Journal of dairy science 2021 Apr;104(4):4516-4528
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L
Food & function 2021 Apr 7;12(7):3120-3131
Food & function 2021 Apr 7;12(7):3120-3131
S-allyl cysteine ameliorates heat stress-induced oxidative stress by activating Nrf2/HO-1 signaling pathway in BMECs.
Wang Y, Wang HL, Xing GD, Qian Y, Zhong JF, Chen KL
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Toxicology and applied pharmacology 2021 Apr 1;416:115469
Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis.
Zhang J, Jiang D, Lin S, Cheng Y, Pan J, Ding W, Chen Y, Fan J
Life sciences 2021 Apr 1;270:119131
Life sciences 2021 Apr 1;270:119131
Icariin Prevents Extracellular Matrix Accumulation and Ameliorates Experimental Diabetic Kidney Disease by Inhibiting Oxidative Stress via GPER Mediated p62-Dependent Keap1 Degradation and Nrf2 Activation.
Wang K, Zheng X, Pan Z, Yao W, Gao X, Wang X, Ding X
Frontiers in cell and developmental biology 2020;8:559
Frontiers in cell and developmental biology 2020;8:559
Moderate Fluid Shear Stress Regulates Heme Oxygenase-1 Expression to Promote Autophagy and ECM Homeostasis in the Nucleus Pulposus Cells.
Chen S, Qin L, Wu X, Fu X, Lin S, Chen D, Xiao G, Shao Z, Cao H
Frontiers in cell and developmental biology 2020;8:127
Frontiers in cell and developmental biology 2020;8:127
Fenpropathrin induces degeneration of dopaminergic neurons via disruption of the mitochondrial quality control system.
Jiao Z, Wu Y, Qu S
Cell death discovery 2020;6:78
Cell death discovery 2020;6:78
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κB Pathway.
Wu J, Yang CL, Sha YK, Wu Y, Liu ZY, Yuan ZH, Sun ZL
The American journal of Chinese medicine 2020;48(1):127-142
The American journal of Chinese medicine 2020;48(1):127-142
Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
The Journal of toxicological sciences 2020;45(11):673-680
The Journal of toxicological sciences 2020;45(11):673-680
Effects of Compound Centella on Oxidative Stress and Keap1-Nrf2-ARE Pathway Expression in Diabetic Kidney Disease Rats.
Zhu Q, Zeng J, Li J, Chen X, Miao J, Jin Q, Chen H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9817932
Heme Oxygenase-1-Mediated Autophagy Protects against Oxidative Damage in Rat Nucleus Pulposus-Derived Mesenchymal Stem Cells.
Chen S, Liu S, Zhao L, Lin H, Ma K, Shao Z
Oxidative medicine and cellular longevity 2020;2020:9349762
Oxidative medicine and cellular longevity 2020;2020:9349762
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Meng X, Zhang C, Guo Y, Han Y, Wang C, Chu H, Kong L, Ma H
Oxidative medicine and cellular longevity 2020;2020:8787156
Oxidative medicine and cellular longevity 2020;2020:8787156
Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway.
Li X, Zou Y, Xing J, Fu YY, Wang KY, Wan PZ, Zhai XY
Oxidative medicine and cellular longevity 2020;2020:6286984
Oxidative medicine and cellular longevity 2020;2020:6286984
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose-Induced Oxidative Stress in HUVECs.
Tian TT, Li QR, Gan SQ, Chang CR, Shen XC
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Evidence-based complementary and alternative medicine : eCAM 2020;2020:5172765
Fasting Induces Hepatocellular Carcinoma Cell Apoptosis by Inhibiting SET8 Expression.
Qi J, Chen X, Wu Q, Wang J, Zhang H, Mao A, Zhu M, Miao C
Oxidative medicine and cellular longevity 2020;2020:3985089
Oxidative medicine and cellular longevity 2020;2020:3985089
Ferryl Hemoglobin Inhibits Osteoclastic Differentiation of Macrophages in Hemorrhaged Atherosclerotic Plaques.
Zavaczki E, Gáll T, Zarjou A, Hendrik Z, Potor L, Tóth CZ, Méhes G, Gyetvai Á, Agarwal A, Balla G, Balla J
Oxidative medicine and cellular longevity 2020;2020:3721383
Oxidative medicine and cellular longevity 2020;2020:3721383
Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice.
Du J, He W, Zhang C, Wu J, Li Z, Wang M, Feng S, Liang G
BioMed research international 2020;2020:3243906
BioMed research international 2020;2020:3243906
Inhibition of Brd4 by JQ1 Promotes Functional Recovery From Spinal Cord Injury by Activating Autophagy.
Li Y, Xiang J, Zhang J, Lin J, Wu Y, Wang X
Frontiers in cellular neuroscience 2020;14:555591
Frontiers in cellular neuroscience 2020;14:555591
Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis.
Kong J, Wang J, Gong X, Zheng X, Chen T
Drug design, development and therapy 2020;14:5521-5533
Drug design, development and therapy 2020;14:5521-5533
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D
Drug design, development and therapy 2020;14:1971-1982
Drug design, development and therapy 2020;14:1971-1982
Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats.
Liu Y, Liang Y, Zheng B, Chu L, Ma D, Wang H, Chu X, Zhang J
Drug design, development and therapy 2020;14:1921-1931
Drug design, development and therapy 2020;14:1921-1931
4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.
Wei X, Wang H, Sun X, Huang X, Xu W, Liang Y, Liu L, Mo S, Lin X, Lin J
American journal of translational research 2020;12(5):2169-2180
American journal of translational research 2020;12(5):2169-2180
Detrimental Effect of Sitagliptin Induced Autophagy on Multiterritory Perforator Flap Survival.
Chen Z, Zhang C, Ma H, Huang Z, Li J, Lou J, Li B, Tu Q, Gao W
Frontiers in pharmacology 2020;11:951
Frontiers in pharmacology 2020;11:951
Bungeanum Improves Cognitive Dysfunction and Neurological Deficits in D-Galactose-Induced Aging Mice via Activating PI3K/Akt/Nrf2 Signaling Pathway.
Zhao M, Tang X, Gong D, Xia P, Wang F, Xu S
Frontiers in pharmacology 2020;11:71
Frontiers in pharmacology 2020;11:71
Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity.
Deng HF, Yue LX, Wang NN, Zhou YQ, Zhou W, Liu X, Ni YH, Huang CS, Qiu LZ, Liu H, Tan HL, Tang XL, Wang YG, Ma ZC, Gao Y
Frontiers in pharmacology 2020;11:624529
Frontiers in pharmacology 2020;11:624529
Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss.
Qi D, Liu H, Sun X, Luo D, Zhu M, Tao T, Gao C, Zhou C, Zhou W, Xiao J
Frontiers in pharmacology 2020;11:621110
Frontiers in pharmacology 2020;11:621110
Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis.
Zhuang K, Jiang X, Liu R, Ye C, Wang Y, Wang Y, Quan S, Huang H
Frontiers in pharmacology 2020;11:616378
Frontiers in pharmacology 2020;11:616378
Butylphthalide Inhibits Autophagy and Promotes Multiterritory Perforator Flap Survival.
Li B, Chen Z, Luo X, Zhang C, Chen H, Wang S, Zhao M, Ma H, Liu J, Cheng M, Yang Y, Yan H
Frontiers in pharmacology 2020;11:612932
Frontiers in pharmacology 2020;11:612932
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Hu J, Zhu Z, Ying H, Yao J, Ma H, Li L, Zhao Y
Frontiers in pharmacology 2020;11:605065
Frontiers in pharmacology 2020;11:605065
Cardamonin Reduces Acetaminophen-Induced Acute Liver Injury in Mice via Activating Autophagy and NFE2L2 Signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Sun X, Jia H, Zhao C, Xu C
Frontiers in pharmacology 2020;11:601716
Frontiers in pharmacology 2020;11:601716
MicroRNA-34a Inhibition Alleviates Lung Injury in Cecal Ligation and Puncture Induced Septic Mice.
Chen S, Ding R, Hu Z, Yin X, Xiao F, Zhang W, Yan S, Lv C
Frontiers in immunology 2020;11:1829
Frontiers in immunology 2020;11:1829
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss.
Wang J, Fang Z, Song C, Kang H, Guo Q, Dong Y, Zhang Y, Peng R, Guan H, Li F
Frontiers in pharmacology 2020;11:1175
Frontiers in pharmacology 2020;11:1175
Kaempferol Protects Blood Vessels From Damage Induced by Oxidative Stress and Inflammation in Association With the Nrf2/HO-1 Signaling Pathway.
Yao H, Sun J, Wei J, Zhang X, Chen B, Lin Y
Frontiers in pharmacology 2020;11:1118
Frontiers in pharmacology 2020;11:1118
TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress.
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, Chen H, Zhang W, Liu M, Xie L, Zhang H, Xu H, Xiao J
Theranostics 2020;10(20):9280-9302
Theranostics 2020;10(20):9280-9302
Cucurbitacin I induces apoptosis in ovarian cancer cells through oxidative stress and the p190B‑Rac1 signaling axis.
Li R, Xiao J, Tang S, Lin X, Xu H, Han B, Yang M, Liu F
Molecular medicine reports 2020 Sep;22(3):2545-2550
Molecular medicine reports 2020 Sep;22(3):2545-2550
Inhibition of miR-181a-5p reduces astrocyte and microglia activation and oxidative stress by activating SIRT1 in immature rats with epilepsy.
Kong H, Wang H, Zhuo Z, Li Z, Tian P, Wu J, Liu J, Chen Z, Zhang J, Luo Q
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Laboratory investigation; a journal of technical methods and pathology 2020 Sep;100(9):1223-1237
Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway.
Nishikawa S, Inoue Y, Hori Y, Miyajima C, Morishita D, Ohoka N, Hida S, Makino T, Hayashi H
Antioxidants (Basel, Switzerland) 2020 Sep 9;9(9)
Antioxidants (Basel, Switzerland) 2020 Sep 9;9(9)
Effects of grape seed proanthocyanidin B2 pretreatment on oxidative stress and renal tubular epithelial cell apoptosis after renal ischemia reperfusion in mice.
Wang ZS, Zhou HH, Han Q, Guo YL, Li ZY
Acta cirurgica brasileira 2020 Sep 4;35(8):e202000802
Acta cirurgica brasileira 2020 Sep 4;35(8):e202000802
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Jiang TY, Pan YF, Wan ZH, Lin YK, Zhu B, Yuan ZG, Ma YH, Shi YY, Zeng TM, Dong LW, Tan YX, Wang HY
Science translational medicine 2020 Sep 23;12(562)
Science translational medicine 2020 Sep 23;12(562)
Four active monomers from Moutan Cortex exert inhibitory effects against oxidative stress by activating Nrf2/Keap1 signaling pathway.
Zhang B, Yu D, Luo N, Yang C, Zhu Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2020 Sep 1;24(5):373-384
Macrophage GIT1 Contributes to Bone Regeneration by Regulating Inflammatory Responses in an ERK/NRF2-Dependent Way.
Zhao SJ, Liu H, Chen J, Qian DF, Kong FQ, Jie J, Yin GY, Li QQ, Fan J
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2020 Oct;35(10):2015-2031
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2020 Oct;35(10):2015-2031
Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.
Xiong Y, Xin DQ, Hu Q, Wang LX, Qiu J, Yuan HT, Chu XL, Liu DX, Li G, Wang Z
Neural regeneration research 2020 Oct;15(10):1920-1930
Neural regeneration research 2020 Oct;15(10):1920-1930
The Preventive Effects of Xanthohumol on Vascular Calcification Induced by Vitamin D(3) Plus Nicotine.
Liou SF, Nguyen TTN, Hsu JH, Sulistyowati E, Huang SE, Wu BN, Lin MC, Yeh JL
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Antioxidants (Basel, Switzerland) 2020 Oct 6;9(10)
Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.
Li Y, Wu J, Yu S, Zhu J, Zhou Y, Wang P, Li L, Zhao Y
Brain research 2020 Oct 15;1745:146948
Brain research 2020 Oct 15;1745:146948
Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1‑Nrf2/ARE signaling pathway in arsenic trioxide‑toxicated rats.
Li M, Liu P, Xue Y, Liang Y, Shi J, Han X, Zhang J, Chu X, Chu L
Oncology reports 2020 Nov;44(5):2306-2316
Oncology reports 2020 Nov;44(5):2306-2316
A novel danshensu derivative ameliorates experimental colitis by modulating NADPH oxidase 4-dependent NLRP3 inflammasome activation.
Pan LL, Ren Z, Liu Y, Zhao Y, Li H, Pan X, Fang X, Liang W, Wang Y, Yang J, Sun J
Journal of cellular and molecular medicine 2020 Nov;24(22):12955-12969
Journal of cellular and molecular medicine 2020 Nov;24(22):12955-12969
Discovery of a novel ferroptosis inducer-talaroconvolutin A-killing colorectal cancer cells in vitro and in vivo.
Xia Y, Liu S, Li C, Ai Z, Shen W, Ren W, Yang X
Cell death & disease 2020 Nov 17;11(11):988
Cell death & disease 2020 Nov 17;11(11):988
Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis.
Xin X, Li Y, Liu H
Scientific reports 2020 Nov 10;10(1):19426
Scientific reports 2020 Nov 10;10(1):19426
Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.
Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, Yang L
Journal of food biochemistry 2020 May;44(5):e13180
Journal of food biochemistry 2020 May;44(5):e13180
Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.
Yang B, Xue Q, Guo J, Wang X, Zhang Y, Guo K, Li W, Chen S, Xue T, Qi X, Wang J
Autophagy 2020 May;16(5):842-861
Autophagy 2020 May;16(5):842-861
High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.
Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, Mao A, Zhu M
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Acta biochimica et biophysica Sinica 2020 May 26;52(5):506-516
Spinosin Inhibits Aβ(1-42) Production and Aggregation via Activating Nrf2/HO-1 Pathway.
Zhang X, Wang J, Gong G, Ma R, Xu F, Yan T, Wu B, Jia Y
Biomolecules & therapeutics 2020 May 1;28(3):259-266
Biomolecules & therapeutics 2020 May 1;28(3):259-266
Effects of sildenafil on inflammatory injury of the lung in sodium taurocholate-induced severe acute pancreatitis rats.
Fang D, Lin Q, Wang C, Zheng C, Li Y, Huang T, Ni F, Wu Z, Chen B, Sun L
International immunopharmacology 2020 Mar;80:106151
International immunopharmacology 2020 Mar;80:106151
7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway.
Qu Z, Chen Y, Luo ZH, Shen XL, Hu YJ
The Journal of pharmacy and pharmacology 2020 Mar;72(3):385-395
The Journal of pharmacy and pharmacology 2020 Mar;72(3):385-395
The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Cell proliferation 2020 Mar;53(3):e12779
Cell proliferation 2020 Mar;53(3):e12779
Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss.
Zhu M, Liu H, Sun K, Liu J, Mou Y, Qi D, Zhou C, Abudunaibi M, Tasiken B, Li J, Cheng H, Huang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109769
PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway.
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, Ye Y
Stem cell research & therapy 2020 Mar 30;11(1):140
Stem cell research & therapy 2020 Mar 30;11(1):140
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Lin Z, Fu C, Yan Z, Wu Y, Zhan J, Lou Z, Liao X, Pan J
Food & function 2020 Mar 26;11(3):2654-2666
Food & function 2020 Mar 26;11(3):2654-2666
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Li H, Liang M, Wang Z, Zhang Y, Wu Q, Yang L
Journal of medicinal food 2020 Jun;23(6):565-574
Journal of medicinal food 2020 Jun;23(6):565-574
Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression.
Liu J, Tan Y, Yang B, Wu Y, Fan B, Zhu S, Song E, Song Y
Environment international 2020 Jun;139:105701
Environment international 2020 Jun;139:105701
Gastroprotective effect of gallic acid against ethanol-induced gastric ulcer in rats: Involvement of the Nrf2/HO-1 signaling and anti-apoptosis role.
Zhou D, Yang Q, Tian T, Chang Y, Li Y, Duan LR, Li H, Wang SW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110075
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110075
Baicalein Inhibits Benzo[a]pyrene-Induced Toxic Response by Downregulating Src Phosphorylation and by Upregulating NRF2-HMOX1 System.
Tanaka Y, Ito T, Tsuji G, Furue M
Antioxidants (Basel, Switzerland) 2020 Jun 9;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 9;9(6)
Heme oxygenase-1-modified bone marrow mesenchymal stem cells combined with normothermic machine perfusion to protect donation after circulatory death liver grafts.
Cao H, Yang L, Hou B, Sun D, Lin L, Song HL, Shen ZY
Stem cell research & therapy 2020 Jun 5;11(1):218
Stem cell research & therapy 2020 Jun 5;11(1):218
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Jun 15;397:115014
Toxicology and applied pharmacology 2020 Jun 15;397:115014
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Wang Y, Li C, Li J, Wang G, Li L
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Fibroblast growth factor 19 alleviates palmitic acid-induced mitochondrial dysfunction and oxidative stress via the AMPK/PGC-1α pathway in skeletal muscle.
Guo A, Li K, Xiao Q
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Biochemical and biophysical research communications 2020 Jun 11;526(4):1069-1076
Effects of DNA Damage and Oxidative Stress in Human Bronchial Epithelial Cells Exposed to PM(2.5) from Beijing, China, in Winter.
Niu BY, Li WK, Li JS, Hong QH, Khodahemmati S, Gao JF, Zhou ZX
International journal of environmental research and public health 2020 Jul 6;17(13)
International journal of environmental research and public health 2020 Jul 6;17(13)
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells.
Jasek-Gajda E, Jurkowska H, Jasińska M, Lis GJ
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Antioxidants (Basel, Switzerland) 2020 Jul 17;9(7)
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
Bach1-induced suppression of angiogenesis is dependent on the BTB domain.
Jiang L, Jia M, Wei X, Guo J, Hao S, Mei A, Zhi X, Wang X, Li Q, Jin J, Zhang J, Li S, Meng D
EBioMedicine 2020 Jan;51:102617
EBioMedicine 2020 Jan;51:102617
Levo-corydalmine Attenuates Vincristine-Induced Neuropathic Pain in Mice by Upregulating the Nrf2/HO-1/CO Pathway to Inhibit Connexin 43 Expression.
Zhou L, Ao L, Yan Y, Li C, Li W, Ye A, Liu J, Hu Y, Fang W, Li Y
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jan;17(1):340-355
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jan;17(1):340-355
Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway.
Dong Y, Xing Y, Sun J, Sun W, Xu Y, Quan C
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Molecules (Basel, Switzerland) 2020 Jan 30;25(3)
Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy.
Xu Q, Shi W, Lv P, Meng W, Mao G, Gong C, Chen Y, Wei Y, He X, Zhao J, Han H, Sun M, Xiao K
Cell death & disease 2020 Jan 2;11(1):6
Cell death & disease 2020 Jan 2;11(1):6
Polychlorinated biphenyl quinone promotes macrophage polarization to CD163(+) cells through Nrf2 signaling pathway.
Liu J, Yang B, Wang Y, Wu Y, Fan B, Zhu S, Song E, Song Y
Environmental pollution (Barking, Essex : 1987) 2020 Feb;257:113587
Environmental pollution (Barking, Essex : 1987) 2020 Feb;257:113587
Protective properties of heme oxygenase-1 expressed in umbilical cord mesenchymal stem cells help restore the ovarian function of premature ovarian failure mice through activating the JNK/Bcl-2 signal pathway-regulated autophagy and upregulating the circulating of CD8(+)CD28(-) T cells.
Yin N, Wu C, Qiu J, Zhang Y, Bo L, Xu Y, Shi M, Zhu S, Yang G, Mao C
Stem cell research & therapy 2020 Feb 4;11(1):49
Stem cell research & therapy 2020 Feb 4;11(1):49
H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron.
Mesquita G, Silva T, Gomes AC, Oliveira PF, Alves MG, Fernandes R, Almeida AA, Moreira AC, Gomes MS
Scientific reports 2020 Feb 20;10(1):3061
Scientific reports 2020 Feb 20;10(1):3061
NR1D1 modulates synovial inflammation and bone destruction in rheumatoid arthritis.
Liu H, Zhu Y, Gao Y, Qi D, Zhao L, Zhao L, Liu C, Tao T, Zhou C, Sun X, Guo F, Xiao J
Cell death & disease 2020 Feb 18;11(2):129
Cell death & disease 2020 Feb 18;11(2):129
Syringin protects against colitis by ameliorating inflammation.
Zhang H, Gu H, Jia Q, Zhao Y, Li H, Shen S, Liu X, Wang G, Shi Q
Archives of biochemistry and biophysics 2020 Feb 15;680:108242
Archives of biochemistry and biophysics 2020 Feb 15;680:108242
Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses.
Kang L, Liu S, Li J, Tian Y, Xue Y, Liu X
Life sciences 2020 Feb 15;243:117244
Life sciences 2020 Feb 15;243:117244
Protection of diabetes-induced kidney injury by phosphocreatine via the regulation of ERK/Nrf2/HO-1 signaling pathway.
Shopit A, Niu M, Wang H, Tang Z, Li X, Tesfaldet T, Ai J, Ahmad N, Al-Azab M, Tang Z
Life sciences 2020 Feb 1;242:117248
Life sciences 2020 Feb 1;242:117248
Maresin 1 mitigates concanavalin A-induced acute liver injury in mice by inhibiting ROS-mediated activation of NF-κB signaling.
Zhang P, Yin Y, Wang T, Li W, Li C, Zeng X, Yang W, Zhang R, Tang Y, Shi L, Li R, Tao K
Free radical biology & medicine 2020 Feb 1;147:23-36
Free radical biology & medicine 2020 Feb 1;147:23-36
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl(4)-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Zhang X, Feng J, Su S, Huang L
Pharmaceutical biology 2020 Dec;58(1):239-246
Pharmaceutical biology 2020 Dec;58(1):239-246
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Guo H, Wang Y, Liu D
Acta histochemica 2020 Dec;122(8):151620
Acta histochemica 2020 Dec;122(8):151620
Enterovirus 71 induces neural cell apoptosis and autophagy through promoting ACOX1 downregulation and ROS generation.
You L, Chen J, Liu W, Xiang Q, Luo Z, Wang W, Xu W, Wu K, Zhang Q, Liu Y, Wu J
Virulence 2020 Dec;11(1):537-553
Virulence 2020 Dec;11(1):537-553
Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.
Chen X, Amorim JA, Moustafa GA, Lee JJ, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG
Aging 2020 Dec 29;12(24):24504-24521
Aging 2020 Dec 29;12(24):24504-24521
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Gu M, Jin J, Ren C, Chen X, Gao W, Wang X, Wu Y, Tian N, Pan Z, Wu A, Zhou Y, Zhang X
Food & function 2020 Dec 1;11(12):10852-10863
Food & function 2020 Dec 1;11(12):10852-10863
Brainstem iron overload and injury in a rat model of brainstem hemorrhage.
Guo X, Ma L, Li H, Qi X, Wei Y, Duan Z, Xu J, Wang C, You C, Tian M
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Aug;29(8):104956
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Aug;29(8):104956
Metformin attenuates cardiac remodeling in mice through the Nrf2/Keap1 signaling pathway.
Du J, Zhu M, Li H, Liang G, Li Y, Feng S
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Experimental and therapeutic medicine 2020 Aug;20(2):838-845
Antioxidant activity of selenium-enriched Chrysomyia megacephala (Fabricius) larvae powder and its impact on intestinal microflora in D-galactose induced aging mice.
Xie D, Jiang L, Lin Y, Liu Z
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
BMC complementary medicine and therapies 2020 Aug 27;20(1):264
Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease.
Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, Leng X
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Antioxidants (Basel, Switzerland) 2020 Aug 25;9(9)
Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Zhang Y, Zhao S, Fu Y, Yan L, Feng Y, Chen Y, Wu Y, Deng Y, Zhang G, Chen Z, Chen Y, Liu T
Cell death & disease 2020 Aug 18;11(8):641
Cell death & disease 2020 Aug 18;11(8):641
Silychristin A activates Nrf2-HO-1/SOD2 pathway to reduce apoptosis and improve GLP-1 production through upregulation of estrogen receptor α in GLUTag cells.
Wang J, Zhang X, Zhang L, Yan T, Wu B, Xu F, Jia Y
European journal of pharmacology 2020 Aug 15;881:173236
European journal of pharmacology 2020 Aug 15;881:173236
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
Huang K, Zhao X
Experimental cell research 2020 Aug 15;393(2):112100
Experimental cell research 2020 Aug 15;393(2):112100
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis.
Kuo PC, Weng WT, Scofield BA, Paraiso HC, Brown DA, Wang PY, Yu IC, Yen JH
Journal of neuroinflammation 2020 Apr 29;17(1):138
Journal of neuroinflammation 2020 Apr 29;17(1):138
Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice.
Xian P, Hei Y, Wang R, Wang T, Yang J, Li J, Di Z, Liu Z, Baskys A, Liu W, Wu S, Long Q
Theranostics 2019;9(20):5956-5975
Theranostics 2019;9(20):5956-5975
SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway.
Sun X, Wang S, Gai J, Guan J, Li J, Li Y, Zhao J, Zhao C, Fu L, Li Q
Frontiers in oncology 2019;9:754
Frontiers in oncology 2019;9:754
Inhibition of Mitochondrial Complex I Aggravates Folic Acid-Induced Acute Kidney Injury.
Zhang W, Yang Y, Gao H, Zhang Y, Jia Z, Huang S
Kidney & blood pressure research 2019;44(5):1002-1013
Kidney & blood pressure research 2019;44(5):1002-1013
KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.
Gao X, Jiang S, Du Z, Ke A, Liang Q, Li X
Oxidative medicine and cellular longevity 2019;2019:8564681
Oxidative medicine and cellular longevity 2019;2019:8564681
CCl(4)-Induced Liver Injury Was Ameliorated by Qi-Ge Decoction through the Antioxidant Pathway.
Peng C, Zhou ZM, Li J, Luo Y, Zhou YS, Ke XH, Huang KE
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Evidence-based complementary and alternative medicine : eCAM 2019;2019:5941263
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Zhao K, Li Y, Wang Z, Han N, Wang Y
BioMed research international 2019;2019:4348973
BioMed research international 2019;2019:4348973
Prevention of Huntington's Disease-Like Behavioral Deficits in R6/1 Mouse by Tolfenamic Acid Is Associated with Decreases in Mutant Huntingtin and Oxidative Stress.
Liu P, Li Y, Yang W, Liu D, Ji X, Chi T, Guo Z, Li L, Zou L
Oxidative medicine and cellular longevity 2019;2019:4032428
Oxidative medicine and cellular longevity 2019;2019:4032428
Salvianolic Acid A Protects the Kidney against Oxidative Stress by Activating the Akt/GSK-3β/Nrf2 Signaling Pathway and Inhibiting the NF-κB Signaling Pathway in 5/6 Nephrectomized Rats.
Zhang HF, Wang JH, Wang YL, Gao C, Gu YT, Huang J, Wang JH, Zhang Z
Oxidative medicine and cellular longevity 2019;2019:2853534
Oxidative medicine and cellular longevity 2019;2019:2853534
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Yan X, Fu X, Jia Y, Ma X, Tao J, Yang T, Ma H, Liang X, Liu X, Yang J, Wei J
Oxidative medicine and cellular longevity 2019;2019:2654910
Oxidative medicine and cellular longevity 2019;2019:2654910
CGRP Reduces Apoptosis of DRG Cells Induced by High-Glucose Oxidative Stress Injury through PI3K/AKT Induction of Heme Oxygenase-1 and Nrf-2 Expression.
Liu Y, Zhang S, Xue J, Wei Z, Ao P, Shen B, Ding L
Oxidative medicine and cellular longevity 2019;2019:2053149
Oxidative medicine and cellular longevity 2019;2019:2053149
Metformin Promotes the Survival of Random-Pattern Skin Flaps by Inducing Autophagy via the AMPK-mTOR-TFEB signaling pathway.
Wu H, Ding J, Li S, Lin J, Jiang R, Lin C, Dai L, Xie C, Lin D, Xu H, Gao W, Zhou K
International journal of biological sciences 2019;15(2):325-340
International journal of biological sciences 2019;15(2):325-340
Therapeutic potential of pravastatin for random skin flaps necrosis: involvement of promoting angiogenesis and inhibiting apoptosis and oxidative stress.
Lin J, Jia C, Wang Y, Jiang S, Jia Z, Chen N, Sheng S, Li S, Jiang L, Xu H, Zhou K, Chen Y
Drug design, development and therapy 2019;13:1461-1472
Drug design, development and therapy 2019;13:1461-1472
Protective effects of resveratrol on random-pattern skin flap survival: an experimental study.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
American journal of translational research 2019;11(1):379-392
American journal of translational research 2019;11(1):379-392
FGF10 Enhances Peripheral Nerve Regeneration via the Preactivation of the PI3K/Akt Signaling-Mediated Antioxidant Response.
Dong L, Li R, Li D, Wang B, Lu Y, Li P, Yu F, Jin Y, Ni X, Wu Y, Yang S, Lv G, Li X, Xiao J, Wang J
Frontiers in pharmacology 2019;10:1224
Frontiers in pharmacology 2019;10:1224
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy.
Li J, Bao G, ALyafeai E, Ding J, Li S, Sheng S, Shen Z, Jia Z, Lin C, Zhang C, Lou Z, Xu H, Gao W, Zhou K
Frontiers in pharmacology 2019;10:1017
Frontiers in pharmacology 2019;10:1017
Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.
Zhang C, Zhan J, Zhao M, Dai H, Deng Y, Zhou W, Zhao L
Neurotoxicology 2019 Sep;74:74-80
Neurotoxicology 2019 Sep;74:74-80
Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation.
Zheng J, Tian X, Zhang W, Zheng P, Huang F, Ding G, Yang Z
Marine drugs 2019 Sep 27;17(10)
Marine drugs 2019 Sep 27;17(10)
The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice.
Lin F, Yang D, Huang Y, Zhao Y, Ye J, Xiao M
Marine drugs 2019 Sep 20;17(10)
Marine drugs 2019 Sep 20;17(10)
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Jing L, Jiang JR, Liu DM, Sheng JW, Zhang WF, Li ZJ, Wei LY
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Molecules (Basel, Switzerland) 2019 Sep 16;24(18)
Torularhodin Ameliorates Oxidative Activity in Vitro and d-Galactose-Induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo.
Liu C, Cui Y, Pi F, Guo Y, Cheng Y, Qian H
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
Journal of agricultural and food chemistry 2019 Sep 11;67(36):10059-10068
Xanthohumol inhibits PRRSV proliferation and alleviates oxidative stress induced by PRRSV via the Nrf2-HMOX1 axis.
Liu X, Song Z, Bai J, Nauwynck H, Zhao Y, Jiang P
Veterinary research 2019 Sep 11;50(1):61
Veterinary research 2019 Sep 11;50(1):61
The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.
Kato R, Ijiri Y, Hayashi T, Uetrecht J
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096
Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice.
Gao W, Wang W, Zhang J, Deng P, Hu J, Yang J, Deng Z
Metabolic brain disease 2019 Oct;34(5):1267-1280
Metabolic brain disease 2019 Oct;34(5):1267-1280
Berberine ameliorates CCl4‑induced liver injury in rats through regulation of the Nrf2‑Keap1‑ARE and p53 signaling pathways.
Han CY, Sun TT, Xv GP, Wang SS, Gu JG, Liu CY
Molecular medicine reports 2019 Oct;20(4):3095-3102
Molecular medicine reports 2019 Oct;20(4):3095-3102
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress.
Xie YK, Zhou X, Yuan HT, Qiu J, Xin DQ, Chu XL, Wang DC, Wang Z
Neural regeneration research 2019 Oct;14(10):1734-1742
Neural regeneration research 2019 Oct;14(10):1734-1742
Phytochemical composition, isolation and hepatoprotective activity of active fraction from Veronica ciliata against acetaminophen-induced acute liver injury via p62-Keap1-Nrf2 signaling pathway.
Lu Q, Tan S, Gu W, Li F, Hua W, Zhang S, Chen F, Tang L
Journal of ethnopharmacology 2019 Oct 28;243:112089
Journal of ethnopharmacology 2019 Oct 28;243:112089
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Yang HM, Li SZ
Brain sciences 2019 Oct 12;9(10)
Brain sciences 2019 Oct 12;9(10)
The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells.
Yao B, He J, Yin X, Shi Y, Wan J, Tian Z
Toxicology letters 2019 Nov;316:109-118
Toxicology letters 2019 Nov;316:109-118
Sodium/calcium overload and Sirt1/Nrf2/OH-1 pathway are critical events in mercuric chloride-induced nephrotoxicity.
Li S, Jiang X, Luo Y, Zhou B, Shi M, Liu F, Sha A
Chemosphere 2019 Nov;234:579-588
Chemosphere 2019 Nov;234:579-588
Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis.
Sun K, Luo J, Jing X, Guo J, Yao X, Hao X, Ye Y, Liang S, Lin J, Wang G, Guo F
Aging 2019 Nov 26;11(22):10513-10531
Aging 2019 Nov 26;11(22):10513-10531
FGF21 augments autophagy in random-pattern skin flaps via AMPK signaling pathways and improves tissue survival.
Zhou K, Chen H, Lin J, Xu H, Wu H, Bao G, Li J, Deng X, Shui X, Gao W, Ding J, Xiao J, Xu H
Cell death & disease 2019 Nov 18;10(12):872
Cell death & disease 2019 Nov 18;10(12):872
The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice.
Liao Z, Zhang J, Wang J, Yan T, Xu F, Wu B, Xiao F, Bi K, Niu J, Jia Y
International journal of biological macromolecules 2019 Nov 1;140:568-576
International journal of biological macromolecules 2019 Nov 1;140:568-576
Predictable chronic mild stress promotes recovery from LPS-induced depression.
Dang R, Guo YY, Zhang K, Jiang P, Zhao MG
Molecular brain 2019 May 3;12(1):42
Molecular brain 2019 May 3;12(1):42
Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.
Liao Z, Zhang J, Liu B, Yan T, Xu F, Xiao F, Wu B, Bi K, Jia Y
Molecules (Basel, Switzerland) 2019 May 17;24(10)
Molecules (Basel, Switzerland) 2019 May 17;24(10)
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway.
Wang H, Wei W, Lan X, Liu N, Li Y, Ma H, Sun T, Peng X, Zhuang C, Yu J
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
ACS chemical neuroscience 2019 May 15;10(5):2276-2286
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Yang P, Zhou Y, Xia Q, Yao L, Chang X
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Biological & pharmaceutical bulletin 2019 May 1;42(5):721-727
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway.
Zhong L, Hao H, Chen D, Hou Q, Zhu Z, He W, Sun S, Sun M, Li M, Fu X
Journal of cellular physiology 2019 Mar;234(3):2606-2617
Journal of cellular physiology 2019 Mar;234(3):2606-2617
The harmful effects of acute PM(2.5) exposure to the heart and a novel preventive and therapeutic function of CEOs.
Dong L, Sun W, Li F, Shi M, Meng X, Wang C, Meng M, Tang W, Liu H, Wang L, Song L
Scientific reports 2019 Mar 5;9(1):3495
Scientific reports 2019 Mar 5;9(1):3495
Neuroprotective Effect of Dioscin on the Aging Brain.
Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Molecules (Basel, Switzerland) 2019 Mar 30;24(7)
Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo.
Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, Ke P, Zhuang J, Huang X
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
ACS chemical neuroscience 2019 Jun 19;10(6):2903-2914
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
Potent 5-Cyano-6-phenyl-pyrimidin-Based Derivatives Targeting DCN1-UBE2M Interaction.
Zhou W, Ma L, Ding L, Guo Q, He Z, Yang J, Qiao H, Li L, Yang J, Yu S, Zhao L, Wang S, Liu HM, Suo Z, Zhao W
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Journal of medicinal chemistry 2019 Jun 13;62(11):5382-5403
Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.
Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, Wang H, Wang Y, Long L, Tan X, Liu D, Jin T, Wang Y, Wang Y, Liao F, Zhang C, Chen L, Gan Y, Liu Y, Yang F, Huang C, Miao H, Chen J, Cheng T, Fu X, Shi C
Nature communications 2019 Jun 10;10(1):2538
Nature communications 2019 Jun 10;10(1):2538
Hesperetin suppresses RANKL-induced osteoclastogenesis and ameliorates lipopolysaccharide-induced bone loss.
Liu H, Dong Y, Gao Y, Zhao L, Cai C, Qi D, Zhu M, Zhao L, Liu C, Guo F, Xiao J, Huang H
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Journal of cellular physiology 2019 Jul;234(7):11009-11022
Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells.
Hou Y, Li X, Peng S, Yao J, Bai F, Fang J
Journal of agricultural and food chemistry 2019 Jul 24;67(29):8227-8234
Journal of agricultural and food chemistry 2019 Jul 24;67(29):8227-8234
Sestrin2 overexpression attenuates focal cerebral ischemic injury in rat by increasing Nrf2/HO-1 pathway-mediated angiogenesis.
Wang P, Zhao Y, Li Y, Wu J, Yu S, Zhu J, Li L, Zhao Y
Neuroscience 2019 Jul 1;410:140-149
Neuroscience 2019 Jul 1;410:140-149
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, Chen X, Lan X, Li X, Shi X, Li N, Qu X
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Shan H, Li T, Zhang L, Yang R, Li Y, Zhang M, Dong Y, Zhou Y, Xu C, Yang B, Liang H, Gao X, Shan H
EBioMedicine 2019 Jan;39:59-68
EBioMedicine 2019 Jan;39:59-68
14-3-3ζ inhibits heme oxygenase-1 (HO-1) degradation and promotes hepatocellular carcinoma proliferation: involvement of STAT3 signaling.
Song J, Zhang X, Liao Z, Liang H, Chu L, Dong W, Zhang X, Ge Q, Liu Q, Fan P, Zhang Z, Zhang B
Journal of experimental & clinical cancer research : CR 2019 Jan 3;38(1):3
Journal of experimental & clinical cancer research : CR 2019 Jan 3;38(1):3
Antagonistic effect of epigallocatechin-3-gallate on neurotoxicity induced by formaldehyde.
Huang J, Lu Y, Zhang B, Yang S, Zhang Q, Cui H, Lu X, Zhao Y, Yang X, Li R
Toxicology 2019 Jan 15;412:29-36
Toxicology 2019 Jan 15;412:29-36
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329
Metabolic brain disease 2019 Feb;34(1):319-329
Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks.
Wang J, Konishi T
Cancer science 2019 Feb;110(2):686-696
Cancer science 2019 Feb;110(2):686-696
Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms.
Li X, Zhang Q, Hou N, Li J, Liu M, Peng S, Zhang Y, Luo Y, Zhao B, Wang S, Zhang Y, Qiao Y
International journal of molecular sciences 2019 Feb 18;20(4)
International journal of molecular sciences 2019 Feb 18;20(4)
Effect of hydrogen-rich water on the Nrf2/ARE signaling pathway in rats with myocardial ischemia-reperfusion injury.
Li L, Liu T, Liu L, Li S, Zhang Z, Zhang R, Zhou Y, Liu F
Journal of bioenergetics and biomembranes 2019 Dec;51(6):393-402
Journal of bioenergetics and biomembranes 2019 Dec;51(6):393-402
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Wang Z, Liang M, Li H, Cai L, Yang L
International journal of molecular sciences 2019 Dec 6;20(24)
International journal of molecular sciences 2019 Dec 6;20(24)
Dietary Dihydroartemisinin Supplementation Attenuates Hepatic Oxidative Damage of Weaned Piglets with Intrauterine Growth Retardation through the Nrf2/ARE Signaling Pathway.
Zhao Y, Niu Y, He J, Zhang L, Wang C, Wang T
Animals : an open access journal from MDPI 2019 Dec 13;9(12)
Animals : an open access journal from MDPI 2019 Dec 13;9(12)
The memory improving effects of round scad (Decapterus maruadsi) hydrolysates on sleep deprivation-induced memory deficits in rats via antioxidant and neurotrophic pathways.
Zhang Q, Su G, Zhao T, Wang S, Sun B, Zheng L, Zhao M
Food & function 2019 Dec 11;10(12):7733-7744
Food & function 2019 Dec 11;10(12):7733-7744
Effects of transcription factor EB on oxidative stress and apoptosis induced by high glucose in podocytes.
Kang Y, Li Y, Zhang T, Chi Y, Liu M
International journal of molecular medicine 2019 Aug;44(2):447-456
International journal of molecular medicine 2019 Aug;44(2):447-456
MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.
Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J
Pharmacological research 2019 Aug;146:104276
Pharmacological research 2019 Aug;146:104276
Deferoxamine Alleviates Iron Overload and Brain Injury in a Rat Model of Brainstem Hemorrhage.
Guo X, Qi X, Li H, Duan Z, Wei Y, Zhang F, Tian M, Ma L, You C
World neurosurgery 2019 Aug;128:e895-e904
World neurosurgery 2019 Aug;128:e895-e904
NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells.
Peng D, Lu H, Zhu S, Zhou Z, Hu T, Chen Z, Zaika A, El-Rifai W
Cancer letters 2019 Aug 28;458:46-55
Cancer letters 2019 Aug 28;458:46-55
l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.
Wang Z, Liang M, Li H, Cai L, He H, Wu Q, Yang L
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Journal of the science of food and agriculture 2019 Aug 15;99(10):4849-4862
Soy Isoflavones Improve the Spermatogenic Defects in Diet-Induced Obesity Rats through Nrf2/HO-1 Pathway.
Luo Q, Li Y, Huang C, Cheng D, Ma W, Xia Y, Liu W, Chen Z
Molecules (Basel, Switzerland) 2019 Aug 15;24(16)
Molecules (Basel, Switzerland) 2019 Aug 15;24(16)
Correction: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2019 Aug 1;10(8):5240-5241
Food & function 2019 Aug 1;10(8):5240-5241
Ochratoxin A causes mitochondrial dysfunction, apoptotic and autophagic cell death and also induces mitochondrial biogenesis in human gastric epithelium cells.
Li Q, Dong Z, Lian W, Cui J, Wang J, Shen H, Liu W, Yang J, Zhang X, Cui H
Archives of toxicology 2019 Apr;93(4):1141-1155
Archives of toxicology 2019 Apr;93(4):1141-1155
Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells.
Gáll T, Pethő D, Nagy A, Hendrik Z, Méhes G, Potor L, Gram M, Åkerström B, Smith A, Nagy P, Balla G, Balla J
Frontiers in physiology 2018;9:1595
Frontiers in physiology 2018;9:1595
Salvianolic Acid B Promotes the Survival of Random-Pattern Skin Flaps in Rats by Inducing Autophagy.
Lin J, Lin R, Li S, Wu H, Ding J, Xiang G, Li S, Wang Y, Lin D, Gao W, Kong J, Xu H, Zhou K
Frontiers in pharmacology 2018;9:1178
Frontiers in pharmacology 2018;9:1178
Hydrogen Sulfide Abrogates Hemoglobin-Lipid Interaction in Atherosclerotic Lesion.
Potor L, Nagy P, Méhes G, Hendrik Z, Jeney V, Pethő D, Vasas A, Pálinkás Z, Balogh E, Gyetvai Á, Whiteman M, Torregrossa R, Wood ME, Olvasztó S, Nagy P, Balla G, Balla J
Oxidative medicine and cellular longevity 2018;2018:3812568
Oxidative medicine and cellular longevity 2018;2018:3812568
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H, Wu YC
Frontiers in aging neuroscience 2018;10:121
Frontiers in aging neuroscience 2018;10:121
Resveratrol relieves particulate matter (mean diameter < 2.5 μm)-induced oxidative injury of lung cells through attenuation of autophagy deregulation.
Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, Li X, Xie C, Zhong C, Fu S
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Journal of applied toxicology : JAT 2018 Sep;38(9):1251-1261
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway.
Wang K, Lv Q, Miao YM, Qiao SM, Dai Y, Wei ZF
Biochemical pharmacology 2018 Sep;155:494-509
Biochemical pharmacology 2018 Sep;155:494-509
Liver injury induced in Balb/c mice by PM(2.5) exposure and its alleviation by compound essential oils.
Ya P, Xu H, Ma Y, Fang M, Yan X, Zhou J, Li F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:590-598
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:590-598
Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro.
Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, Sun P, Huo X, Ma X, Meng Q, Liu K
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Regulatory toxicology and pharmacology : RTP 2018 Oct;98:58-68
Cyclooxygenase‑2‑mediated upregulation of heme oxygenase 1 mitigates the toxicity of deuterium‑tritium fusion radiation.
Yang X, Liu H, Jiang X, Jin C, Xu Z, Li T, Wang Z, Wang J
International journal of molecular medicine 2018 Oct;42(4):1945-1954
International journal of molecular medicine 2018 Oct;42(4):1945-1954
Ribosomal protein L10 in mitochondria serves as a regulator for ROS level in pancreatic cancer cells.
Yang J, Chen Z, Liu N, Chen Y
Redox biology 2018 Oct;19:158-165
Redox biology 2018 Oct;19:158-165
(2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating.
Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, Li F, Chen A, Huang S
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Journal of cellular biochemistry 2018 Nov;119(11):8981-8995
Beneficial Effects of Exercise Pretreatment in a Sporadic Alzheimer's Rat Model.
Wu C, Yang L, Tucker D, Dong Y, Zhu L, Duan R, Liu TC, Zhang Q
Medicine and science in sports and exercise 2018 May;50(5):945-956
Medicine and science in sports and exercise 2018 May;50(5):945-956
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signaling.
Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, Jiang Z, Fu J, Pi J, Guan D, Zhao R
Toxicology and applied pharmacology 2018 May 1;346:28-36
Toxicology and applied pharmacology 2018 May 1;346:28-36
Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge.
Paraiso HC, Kuo PC, Curfman ET, Moon HJ, Sweazey RD, Yen JH, Chang FL, Yu IC
Journal of neuroinflammation 2018 Mar 29;15(1):100
Journal of neuroinflammation 2018 Mar 29;15(1):100
Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress.
Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J
Redox biology 2018 Jun;16:189-198
Redox biology 2018 Jun;16:189-198
Tert-butylhydroquinone post-treatment attenuates neonatal hypoxic-ischemic brain damage in rats.
Zhang J, Tucker LD, DongYan, Lu Y, Yang L, Wu C, Li Y, Zhang Q
Neurochemistry international 2018 Jun;116:1-12
Neurochemistry international 2018 Jun;116:1-12
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.
Muliaditan T, Caron J, Okesola M, Opzoomer JW, Kosti P, Georgouli M, Gordon P, Lall S, Kuzeva DM, Pedro L, Shields JD, Gillett CE, Diebold SS, Sanz-Moreno V, Ng T, Hoste E, Arnold JN
Nature communications 2018 Jul 27;9(1):2951
Nature communications 2018 Jul 27;9(1):2951
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Luo W, Wang Y, Yang H, Dai C, Hong H, Li J, Liu Z, Guo Z, Chen X, He P, Li Z, Li F, Jiang J, Liu P, Li Z
Aging 2018 Jul 24;10(7):1722-1744
Aging 2018 Jul 24;10(7):1722-1744
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis.
Dai C, Ciccotosto GD, Cappai R, Tang S, Li D, Xie S, Xiao X, Velkov T
Molecular neurobiology 2018 Jan;55(1):421-434
Molecular neurobiology 2018 Jan;55(1):421-434
The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway.
Lin EY, Bayarsengee U, Wang CC, Chiang YH, Cheng CW
Environmental toxicology 2018 Jan;33(1):72-82
Environmental toxicology 2018 Jan;33(1):72-82
Hydrogen-water ameliorates radiation-induced gastrointestinal toxicity via MyD88's effects on the gut microbiota.
Xiao HW, Li Y, Luo D, Dong JL, Zhou LX, Zhao SY, Zheng QS, Wang HC, Cui M, Fan SJ
Experimental & molecular medicine 2018 Jan 26;50(1):e433
Experimental & molecular medicine 2018 Jan 26;50(1):e433
Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2.
Hou Y, Peng S, Li X, Yao J, Xu J, Fang J
ACS chemical neuroscience 2018 Dec 19;9(12):3108-3116
ACS chemical neuroscience 2018 Dec 19;9(12):3108-3116
Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
Li ST, Dai Q, Zhang SX, Liu YJ, Yu QQ, Tan F, Lu SH, Wang Q, Chen JW, Huang HQ, Liu PQ, Li M
Acta pharmacologica Sinica 2018 Aug;39(8):1294-1304
Acta pharmacologica Sinica 2018 Aug;39(8):1294-1304
T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.
Zhang X, Wang Y, Velkov T, Tang S, Dai C
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Apr;114:88-97
Potential Ameliorative Effects of Qing Ye Dan Against Cadmium Induced Prostatic Deficits via Regulating Nrf-2/HO-1 and TGF-β1/Smad Pathways.
Du L, Lei Y, Chen J, Song H, Wu X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1359-1368
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(4):1359-1368
α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage.
Lv C, Maharjan S, Wang Q, Sun Y, Han X, Wang S, Mao Z, Xin Y, Zhang B
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1273-1287
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1273-1287
Non-Lethal Sonodynamic Therapy Inhibits Atherosclerotic Plaque Progression in ApoE-/- Mice and Attenuates ox-LDL-mediated Macrophage Impairment by Inducing Heme Oxygenase-1.
Wang Y, Wang W, Xu H, Sun Y, Sun J, Jiang Y, Yao J, Tian Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(6):2432-2446
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(6):2432-2446
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms.
Li L, Kong L, Song H
Experimental and therapeutic medicine 2017 Sep;14(3):2505-2510
Experimental and therapeutic medicine 2017 Sep;14(3):2505-2510
Vitamin E antagonizes ozone-induced asthma exacerbation in Balb/c mice through the Nrf2 pathway.
Duan L, Li J, Ma P, Yang X, Xu S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):47-56
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):47-56
Reduction of oxidative damages induced by titanium dioxide nanoparticles correlates with induction of the Nrf2 pathway by GSPE supplementation in mice.
Niu L, Shao M, Liu Y, Hu J, Li R, Xie H, Zhou L, Shi L, Zhang R, Niu Y
Chemico-biological interactions 2017 Sep 25;275:133-144
Chemico-biological interactions 2017 Sep 25;275:133-144
An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress.
Liu J, Wang L, Du Y, Liu S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2017 Oct;4(10):1700089
Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H(2)S system: Role of oxidative stress and endoplasmic reticulum stress.
Liu S, Xin D, Wang L, Zhang T, Bai X, Li T, Xie Y, Xue H, Bo S, Liu D, Wang Z
Redox biology 2017 Oct;13:528-540
Redox biology 2017 Oct;13:528-540
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Li D, Dai C, Yang X, Wang F, Yu X, Xiao X, Tang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Establishment and characterization of human osteosarcoma cells resistant to pyropheophorbide-α methyl ester-mediated photodynamic therapy.
Tao Y, Ou Y, Yin H, Chen Y, Zhong S, Gao Y, Zhao Z, He B, Huang Q, Deng Q
International journal of oncology 2017 Nov;51(5):1427-1438
International journal of oncology 2017 Nov;51(5):1427-1438
3H-1,2-Dithiole-3-thione as a novel therapeutic agent for the treatment of ischemic stroke through Nrf2 defense pathway.
Kuo PC, Yu IC, Scofield BA, Brown DA, Curfman ET, Paraiso HC, Chang FL, Yen JH
Brain, behavior, and immunity 2017 May;62:180-192
Brain, behavior, and immunity 2017 May;62:180-192
Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase.
Liu C, Hao Y, Yin F, Zhang Y, Liu J
Cell biology international 2017 May;41(5):544-554
Cell biology international 2017 May;41(5):544-554
Role of the cystathionine β-synthase/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the system.
Jia H, Ye J, You J, Shi X, Kang W, Wang T
Oncology reports 2017 May;37(5):3001-3009
Oncology reports 2017 May;37(5):3001-3009
Effect of ozone oxidative preconditioning on oxidative stress injury in a rat model of kidney transplantation.
Qiu T, Wang ZS, Liu XH, Chen H, Zhou JQ, Chen ZY, Wang M, Jiang GJ, Wang L, Yu G, Zhang L, Shen Y, Zhang L, He L, Wang HX, Zhang WJ
Experimental and therapeutic medicine 2017 May;13(5):1948-1955
Experimental and therapeutic medicine 2017 May;13(5):1948-1955
Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin.
Dai C, Lei L, Li B, Lin Y, Xiao X, Tang S
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Toxicology mechanisms and methods 2017 Mar;27(3):165-172
Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis.
Lu J, Guo S, Xue X, Chen Q, Ge J, Zhuo Y, Zhong H, Chen B, Zhao M, Han W, Suzuki T, Zhu M, Xia L, Schneider C, Blackwell TS, Porter NA, Zheng L, Tsimikas S, Yin H
The Journal of biological chemistry 2017 Mar 31;292(13):5378-5391
The Journal of biological chemistry 2017 Mar 31;292(13):5378-5391
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Gao M, Zhao B, Chen M, Liu Y, Xu M, Wang Z, Liu S, Zhang C
Biomaterials 2017 Jun;130:14-27
Biomaterials 2017 Jun;130:14-27
Global Transcriptomic Profiling of Cortex and Striatum: Cerebral Injury after Ischemia/Reperfusion in a Mouse Model.
Zhao Z, Lu Z, Sun X, Zhao T, Zhang J, Zhou C, Zheng X, Zhang H, Shi G
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Jul;26(7):1622-1634
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017 Jul;26(7):1622-1634
The electrophilic character of quinones is essential for the suppression of Bach1.
Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y
Toxicology 2017 Jul 15;387:17-26
Toxicology 2017 Jul 15;387:17-26
Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin.
Shen S, Li J, You H, Wu Z, Wu Y, Zhao Y, Zhu Y, Guo Q, Li X, Li R, Ma P, Yang X, Chen M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Jan;99:60-69
Heme-oxygenase-1 Production by Intestinal CX3CR1(+) Macrophages Helps to Resolve Inflammation and Prevents Carcinogenesis.
Marelli G, Erreni M, Anselmo A, Taverniti V, Guglielmetti S, Mantovani A, Allavena P
Cancer research 2017 Aug 15;77(16):4472-4485
Cancer research 2017 Aug 15;77(16):4472-4485
(-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1.
Yang D, Xiao CX, Su ZH, Huang MW, Qin M, Wu WJ, Jia WW, Zhu YZ, Hu JF, Liu XH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Phytomedicine : international journal of phytotherapy and phytopharmacology 2017 Aug 15;32:15-23
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways.
Zhang C, Li C, Chen S, Li Z, Jia X, Wang K, Bao J, Liang Y, Wang X, Chen M, Li P, Su H, Wan JB, Lee SMY, Liu K, He C
Redox biology 2017 Apr;11:1-11
Redox biology 2017 Apr;11:1-11
Nitro-oleic acid ameliorates oxygen and glucose deprivation/re-oxygenation triggered oxidative stress in renal tubular cells via activation of Nrf2 and suppression of NADPH oxidase.
Nie H, Xue X, Liu G, Guan G, Liu H, Sun L, Zhao L, Wang X, Chen Z
Free radical research 2016;50(11):1200-1213
Free radical research 2016;50(11):1200-1213
Protective Effects of Hydrogen Sulfide in the Ageing Kidney.
Hou CL, Wang MJ, Sun C, Huang Y, Jin S, Mu XP, Chen Y, Zhu YC
Oxidative medicine and cellular longevity 2016;2016:7570489
Oxidative medicine and cellular longevity 2016;2016:7570489
S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway.
Li W, Ma F, Zhang L, Huang Y, Li X, Zhang A, Hou C, Zhu Y, Zhu Y
Oxidative medicine and cellular longevity 2016;2016:4690857
Oxidative medicine and cellular longevity 2016;2016:4690857
Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.
Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C
PloS one 2016;11(2):e0149032
PloS one 2016;11(2):e0149032
Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats.
Hu Q, Li T, Wang L, Xie Y, Liu S, Bai X, Zhang T, Bo S, Xin D, Xue H, Li G, Wang Z
Frontiers in cellular neuroscience 2016;10:306
Frontiers in cellular neuroscience 2016;10:306
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
Lu L, Dong J, Li D, Zhang J, Fan S
Free radical biology & medicine 2016 Oct;99:463-471
Free radical biology & medicine 2016 Oct;99:463-471
3H-1,2-dithiole-3-thione as a novel therapeutic agent for the treatment of experimental autoimmune encephalomyelitis.
Kuo PC, Brown DA, Scofield BA, Yu IC, Chang FL, Wang PY, Yen JH
Brain, behavior, and immunity 2016 Oct;57:173-186
Brain, behavior, and immunity 2016 Oct;57:173-186
Desferrioxamine reduces ultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1.
Kang H, Yan Y, Jia P, Yang K, Guo C, Chen H, Qi J, Qian N, Xu X, Wang F, Li C, Guo L, Deng L
Cell death & disease 2016 Oct 27;7(10):e2435
Cell death & disease 2016 Oct 27;7(10):e2435
15d-PGJ2 alleviates ConA-induced acute liver injury in mice by up-regulating HO-1 and reducing hepatic cell autophagy.
Chen K, Li J, Li S, Feng J, Wu L, Liu T, Zhang R, Xu S, Cheng K, Zhou Y, Zhou S, Wang F, Dai W, Xia Y, Lu J, Zhou Y, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:183-192
Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity.
Yu G, Deng A, Tang W, Ma J, Yuan C, Ma J
Neurochemistry international 2016 Jun;96:113-20
Neurochemistry international 2016 Jun;96:113-20
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
High expression of heme oxygenase-1 in target organs may attenuate acute graft-versus-host disease through regulation of immune balance of TH17/Treg.
Yu M, Wang J, Fang Q, Liu P, Chen S, Zhe N, Lin X, Zhang Y, Zhao J, Zhou Z
Transplant immunology 2016 Jul;37:10-17
Transplant immunology 2016 Jul;37:10-17
Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats.
Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, Xu Y, Zhao Y, Wang C, Peng J
Nutrients 2016 Jul 8;8(7)
Nutrients 2016 Jul 8;8(7)
Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation.
Zhao L, Xu L, Tao X, Han X, Yin L, Qi Y, Peng J
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Molecules (Basel, Switzerland) 2016 Jul 21;21(7)
Rice protein suppresses ROS generation and stimulates antioxidant gene expression via Nrf2 activation in adult rats.
Li H, He H, Wang Z, Cai J, Sun B, Wu Q, Zhang Y, Zhou G, Yang L
Gene 2016 Jul 10;585(2):256-64
Gene 2016 Jul 10;585(2):256-64
Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling.
Su C, Shi Q, Song X, Fu J, Liu Z, Wang Y, Wang Y, Xia X, Song E, Song Y
Toxicology 2016 Jul 1;363-364:48-57
Toxicology 2016 Jul 1;363-364:48-57
Acute exposure of ozone induced pulmonary injury and the protective role of vitamin E through the Nrf2 pathway in Balb/c mice.
Zhu Y, Li J, Wu Z, Lu Y, You H, Li R, Li B, Yang X, Duan L
Toxicology research 2016 Jan 1;5(1):268-277
Toxicology research 2016 Jan 1;5(1):268-277
P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.
Deng S, Tang S, Dai C, Zhou Y, Yang X, Li D, Xiao X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2016 Feb;88:1-12
Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.
Hu B, Shi C, Xu C, Cao P, Tian Y, Zhang Y, Deng L, Chen H, Yuan W
Scientific reports 2016 Feb 15;6:21190
Scientific reports 2016 Feb 15;6:21190
Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.
Zhang W, Li Y, Ding H, Du Y, Wang L
Renal failure 2016 Aug;38(7):1099-106
Renal failure 2016 Aug;38(7):1099-106
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Zhou ZY, Ren LW, Zhan P, Yang HY, Chai DD, Yu ZW
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell.
Chen N, Wu L, Yuan H, Wang J
International journal of biological sciences 2015;11(7):833-44
International journal of biological sciences 2015;11(7):833-44
Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo.
Shi Z, Niu Y, Wang Q, Shi L, Guo H, Liu Y, Zhu Y, Liu S, Liu C, Chen X, Zhang R
Journal of hazardous materials 2015 Nov 15;298:310-9
Journal of hazardous materials 2015 Nov 15;298:310-9
Loss of protein targeting to glycogen sensitizes human hepatocellular carcinoma cells towards glucose deprivation mediated oxidative stress and cell death.
Yang R, Zhang M, Gustafson AR, Wang E, Cole MP, Tooley CE, Cheng A
Bioscience reports 2015 May 1;35(3)
Bioscience reports 2015 May 1;35(3)
Neohesperidin Dihydrochalcone versus CCl₄-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation.
Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, Chen H, Lu B, Sun Z, Wu S, Yang S, Li X, Ye X, Song E, Song Y
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Journal of agricultural and food chemistry 2015 Jun 10;63(22):5468-75
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
tert-Butylhydroquinone mobilizes intracellular-bound zinc to stabilize Nrf2 through inhibiting phosphatase activity.
Chen Y, Wang S, Fu X, Zhou W, Hong W, Zou D, Li X, Liu J, Ran P, Li B
American journal of physiology. Cell physiology 2015 Aug 1;309(3):C148-58
American journal of physiology. Cell physiology 2015 Aug 1;309(3):C148-58
Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation.
Su C, Zhang P, Song X, Shi Q, Fu J, Xia X, Bai H, Hu L, Xu D, Song E, Song Y
Chemical research in toxicology 2015 Apr 20;28(4):765-74
Chemical research in toxicology 2015 Apr 20;28(4):765-74
Effect of Nrf2 on rat ovarian tissues against atrazine-induced anti-oxidative response.
Zhao F, Li K, Zhao L, Liu J, Suo Q, Zhao J, Wang H, Zhao S
International journal of clinical and experimental pathology 2014;7(6):2780-9
International journal of clinical and experimental pathology 2014;7(6):2780-9
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Xu D, Hu L, Su C, Xia X, Zhang P, Fu J, Wang W, Xu D, Du H, Hu Q, Song E, Song Y
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Heme oxygenase-1 silencing increases the sensitivity of human osteosarcoma MG63 cells to arsenic trioxide.
Zhong L, Wang Y, Li W, Gu J, Li X, Wang X, Yue Z, Mu Y, Bai J, Li R, Zhang H
Molecular and cellular biochemistry 2014 Jul;392(1-2):135-44
Molecular and cellular biochemistry 2014 Jul;392(1-2):135-44
Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats.
Dong D, Qi Y, Xu L, Yin L, Xu Y, Han X, Zhao Y, Peng J
Food & function 2014 Dec;5(12):3065-3075
Food & function 2014 Dec;5(12):3065-3075
Inhibition of NADPH oxidase 4-related signaling by sodium hydrosulfide attenuates myocardial fibrotic response.
Pan LL, Liu XH, Shen YQ, Wang NZ, Xu J, Wu D, Xiong QH, Deng HY, Huang GY, Zhu YZ
International journal of cardiology 2013 Oct 9;168(4):3770-8
International journal of cardiology 2013 Oct 9;168(4):3770-8
Heme catabolism by heme oxygenase-1 confers host resistance to Mycobacterium infection.
Silva-Gomes S, Appelberg R, Larsen R, Soares MP, Gomes MS
Infection and immunity 2013 Jul;81(7):2536-45
Infection and immunity 2013 Jul;81(7):2536-45
Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice.
He HJ, Wang GY, Gao Y, Ling WH, Yu ZW, Jin TR
World journal of diabetes 2012 May 15;3(5):94-104
World journal of diabetes 2012 May 15;3(5):94-104
Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-κB pathways.
Liu XH, Pan LL, Yang HB, Gong QH, Zhu YZ
European journal of pharmacology 2012 Apr 5;680(1-3):108-14
European journal of pharmacology 2012 Apr 5;680(1-3):108-14
Proteomic characterisation of pancreatic islet beta-cells stimulated with pancreatic carcinoma cell conditioned medium.
Song G, Cui Y, Zhong N, Han J
Journal of clinical pathology 2009 Sep;62(9):802-7
Journal of clinical pathology 2009 Sep;62(9):802-7
Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC.
Chen N, Sun W, Deng X, Hao Y, Chen X, Xing B, Jia W, Ma J, Wei H, Zhu Y, Qian X, Jiang Y, He F
Proteomics 2008 Dec;8(23-24):5108-18
Proteomics 2008 Dec;8(23-24):5108-18
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 10701-1-AP(HMOX1 antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HMOX1 (IP:10701-1-AP, 3ug; Detection:10701-1-AP 1:1000) with HeLa cells lysate 3000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 10701-1-AP(HMOX1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HMOX1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HMOX1. This antibody recognizes human, mouse, rat antigen. The HMOX1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
