Antibody data
- Antibody Data
- Antigen structure
- References [14]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- M00253 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-Heme Oxygenase 1 HMOX1 Rabbit Monoclonal Antibody
- Antibody type
- Monoclonal
- Description
- Monoclonal antibody for HO 1/HMOX1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: Flow Cytometry, IP, IHC, WB. Reactive species: Human, Mouse HO 1/HMOX1 information: Molecular Weight: 32819 MW; Subcellular Localization: Microsome . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side ; Tissue Specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Antibody clone number
- AEG-8
- Vial size
- 100ug/vial
- Concentration
- 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
- Storage
- At -20°C for one year. Avoid repeated freezing and thawing.
Submitted references RNA-seq combined network pharmacology reveals that Fu-Gan-Wan (FGW) inhibits liver fibrosis via NF-κB/CCL2/CCR2 and lipid peroxidation via Nrf2/HMOX1 signaling pathway.
Cell-Cycle-related Protein Centromere Protein F Deficiency Inhibits Cervical Cancer Cell Growth by Inducing Ferroptosis Via Nrf2 Inactivation.
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Untargeted serum and liver metabolomics analyses reveal the gastroprotective effect of polysaccharide from Evodiae fructus on ethanol-induced gastric ulcer in mice.
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Secoisolariciresinol diglucoside Ameliorates Osteoarthritis via Nuclear factor-erythroid 2-related factor-2/ nuclear factor kappa B Pathway: In vitro and in vivo experiments.
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Vitamin D(3) Protects Mice from Diquat-Induced Oxidative Stress through the NF-κB/Nrf2/HO-1 Signaling Pathway.
Hepatocellular iNOS protects liver from NASH through Nrf2-dependent activation of HO-1.
miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing apoptosis in lung cancer cells.
Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury.
Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats.
Shi H, Duan X, Dong J, Tao Y, Lei Y
Journal of ethnopharmacology 2024 May 23;326:117963
Journal of ethnopharmacology 2024 May 23;326:117963
Cell-Cycle-related Protein Centromere Protein F Deficiency Inhibits Cervical Cancer Cell Growth by Inducing Ferroptosis Via Nrf2 Inactivation.
Tang XH, Zhao TN, Guo L, Liu XY, Zhang WN, Zhang P
Cell biochemistry and biophysics 2024 Jun;82(2):997-1006
Cell biochemistry and biophysics 2024 Jun;82(2):997-1006
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy.
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C
International journal of molecular medicine 2024 Feb;53(2)
International journal of molecular medicine 2024 Feb;53(2)
Activation of the Nrf-2 pathway by pinocembrin safeguards vertebral endplate chondrocytes against apoptosis and degeneration caused by oxidative stress.
Wang H, Liu X, Yang H, Jing X, Wang W, Liu X, Zhang B, Liu X, Shao Y, Cui X
Life sciences 2023 Nov 15;333:122162
Life sciences 2023 Nov 15;333:122162
Untargeted serum and liver metabolomics analyses reveal the gastroprotective effect of polysaccharide from Evodiae fructus on ethanol-induced gastric ulcer in mice.
Luo JH, Zou WS, Li J, Liu W, Huang J, Wu HW, Shen JL, Li F, Yuan JS, Tao AK, Gong L, Zhang J, Wang XY
International journal of biological macromolecules 2023 Mar 31;232:123481
International journal of biological macromolecules 2023 Mar 31;232:123481
PTEN inhibitor VO-OHpic protects endplate chondrocytes against apoptosis and calcification via activating Nrf-2 signaling pathway.
Cui X, Liu X, Kong P, Du T, Li T, Yang G, Zhang W, Jing X, Wang W
Aging 2023 Mar 24;15(6):2275-2292
Aging 2023 Mar 24;15(6):2275-2292
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway.
Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y, Cui X
International immunopharmacology 2023 Jun;119:110159
International immunopharmacology 2023 Jun;119:110159
Secoisolariciresinol diglucoside Ameliorates Osteoarthritis via Nuclear factor-erythroid 2-related factor-2/ nuclear factor kappa B Pathway: In vitro and in vivo experiments.
Zhang Z, Wang S, Liu X, Yang Y, Zhang Y, Li B, Guo F, Liang J, Hong X, Guo R, Zhang B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114964
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114964
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.
Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X, Cui X
Frontiers in pharmacology 2022;13:937502
Frontiers in pharmacology 2022;13:937502
Vitamin D(3) Protects Mice from Diquat-Induced Oxidative Stress through the NF-κB/Nrf2/HO-1 Signaling Pathway.
Zhang H, Liu Y, Fang X, Gu L, Luo C, Chen L, Wang Q
Oxidative medicine and cellular longevity 2021;2021:6776956
Oxidative medicine and cellular longevity 2021;2021:6776956
Hepatocellular iNOS protects liver from NASH through Nrf2-dependent activation of HO-1.
Qiao Y, Li X, Zhang X, Xiao F, Zhu Y, Fang Z, Sun J
Biochemical and biophysical research communications 2019 Jun 25;514(2):372-378
Biochemical and biophysical research communications 2019 Jun 25;514(2):372-378
miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing apoptosis in lung cancer cells.
Gu S, Lai Y, Chen H, Liu Y, Zhang Z
Scientific reports 2017 Sep 22;7(1):12155
Scientific reports 2017 Sep 22;7(1):12155
Nephroprotective Effects of Saponins from Leaves of Panax quinquefolius against Cisplatin-Induced Acute Kidney Injury.
Ma ZN, Li YZ, Li W, Yan XT, Yang G, Zhang J, Zhao LC, Yang LM
International journal of molecular sciences 2017 Jul 13;18(7)
International journal of molecular sciences 2017 Jul 13;18(7)
Influence of heme oxygenase-1 expression on immune liver fibrosis induced by cobalt protoporphyrin in rats.
Wang F, Duan ZJ, Sun YJ
World journal of gastroenterology 2009 Jun 28;15(24):3009-14
World journal of gastroenterology 2009 Jun 28;15(24):3009-14
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Supportive validation
- Submitted by
- Boster Biological Technology (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of paraffin-embedded human liver, using Heme Oxygenase 1 Antibody(M00253)HMOX1 was detected in paraffin-embedded tissue section. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1ug/ml rabbit anti-HMOX1 Antibody (M00253)overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen.
- Additional image