HPA038002

antibody from Atlas Antibodies

Targeting: METTL14 KIAA1627

Provider product page for HPA038002

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [102]
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Product number: HPA038002 - Provider product page
Provider: Atlas Antibodies
Proper citation: Atlas Antibodies Cat#HPA038002, RRID:AB_10672401
Product name: Anti-METTL14
Antibody type: Polyclonal
Description: Polyclonal Antibody against Human METTL14, Gene description: methyltransferase like 14, Alternative Gene Names: KIAA1627, Validated applications: ICC, IHC, Uniprot ID: Q9HCE5, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µl
Concentration: 0.3 mg/ml
Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
Handling: The antibody solution should be gently mixed before use.

METTL14 protein structure - HPA038002 shown in red.

Submitted references Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation

Pomaville M, Chennakesavalu M, Wang P, Jiang Z, Sun H, Ren P, Borchert R, Gupta V, Ye C, Ge R, Zhu Z, Brodnik M, Zhong Y, Moore K, Salwen H, George R, Krajewska M, Chlenski A, Applebaum M, He C, Cohn S
Cell Reports 2024;43(5):114165

m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation

Kahraman S, De Jesus D, Wei J, Brown N, Zou Z, Hu J, Pirouz M, Gregory R, He C, Kulkarni R
The EMBO Journal 2024;43(22):5445-5468

Redox regulation of m6A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes

De Jesus D, Zhang Z, Brown N, Li X, Xiao L, Hu J, Gaffrey M, Fogarty G, Kahraman S, Wei J, Basile G, Rana T, Mathews C, Powers A, Parent A, Atkinson M, Dhe-Paganon S, Eizirik D, Qian W, He C, Kulkarni R
Nature Cell Biology 2024;26(3):421-437

N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1

Xu L, Chen S, Fan Q, Zhu Y, Mei H, Wang J, Yu H, Chen Y, Liu F
BMC Biology 2024;22(1)

METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation

Xue M, Dong L, Zhang H, Li Y, Qiu K, Zhao Z, Gao M, Han L, Chan A, Li W, Leung K, Wang K, Pokharel S, Qing Y, Liu W, Wang X, Ren L, Bi H, Yang L, Shen C, Chen Z, Melstrom L, Li H, Timchenko N, Deng X, Huang W, Rosen S, Tian J, Xu L, Diao J, Chen C, Chen J, Shen B, Chen H, Su R
Journal of Hematology & Oncology 2024;17(1)

N6-methyladenosine modification is not a general trait of viral RNA genomes

Baquero-Pérez B, Yonchev I, Delgado-Tejedor A, Medina R, Puig-Torrents M, Sudbery I, Begik O, Wilson S, Novoa E, Díez J
Nature Communications 2024;15(1)

M6A reduction relieves FUS-associated ALS granules

Di Timoteo G, Giuliani A, Setti A, Biagi M, Lisi M, Santini T, Grandioso A, Mariani D, Castagnetti F, Perego E, Zappone S, Lattante S, Sabatelli M, Rotili D, Vicidomini G, Bozzoni I
Nature Communications 2024;15(1)

METTL3-mediated chromatin contacts promote stress granule phase separation through metabolic reprogramming during senescence

Wang C, Tanizawa H, Hill C, Havas A, Zhang Q, Liao L, Hao X, Lei X, Wang L, Nie H, Qi Y, Tian B, Gardini A, Kossenkov A, Goldman A, Berger S, Noma K, Adams P, Zhang R
Nature Communications 2024;15(1)

FSH induces EMT in ovarian cancer via ALKBH5-regulated Snail m6A demethylation

Xu X, Zhuang X, Yu H, Li P, Li X, Lin H, Teoh J, Chen Y, Yang Y, Cheng Y, Chen W, Fu X
Theranostics 2024;14(5):2151-2166

Antibiotic‐Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m6A Epitranscriptome via Bile Acid Metabolism

Yang M, Zheng X, Fan J, Cheng W, Yan T, Lai Y, Zhang N, Lu Y, Qi J, Huo Z, Xu Z, Huang J, Jiao Y, Liu B, Pang R, Zhong X, Huang S, Luo G, Lee G, Jobin C, Eren A, Chang E, Wei H, Pan T, Wang X
Advanced Science 2024;11(28)

Dynamics of N6-methyladenosine modification during Alzheimer's disease development

Gao S, Wang Y, Li X, Liang Y, Jin Z, Yang B, Yuan T, Tian H, Peng B, Rao Y
Heliyon 2024;10(6):e26911

Overexpression of METTL14 mediates steatohepatitis and insulin resistance in mice

Zhou J, Yang M, Zhai D, Jiang Q, Zhang Q
Heliyon 2024;10(15):e35467

METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma.

Thombare K, Vaid R, Pucci P, Ihrmark Lundberg K, Ayyalusamy R, Baig MH, Mendez A, Burgos-Panadero R, Höppner S, Bartenhagen C, Sjövall D, Rehan AA, Dattatraya Nale S, Djos A, Martinsson T, Jaako P, Dong JJ, Kogner P, Johnsen JI, Fischer M, Turner SD, Mondal T
The EMBO journal 2024 Dec;43(24):6310-6335

Overexpression of VIRMA confers vulnerability to breast cancers via the m6A-dependent regulation of unfolded protein response

Lee Q, Song R, Phan D, Pinello N, Tieng J, Su A, Halstead J, Wong A, van Geldermalsen M, Lee B, Rong B, Cook K, Larance M, Liu R, Lan F, Tiffen J, Wong J
Cellular and Molecular Life Sciences 2023;80(6)

In situ visualization of m6A sites in cellular mRNAs

Sheehan C, Marayati B, Bhatia J, Meyer K
Nucleic Acids Research 2023;51(20):e101-e101

Targeting histone deacetylase suppresses tumor growth through eliciting METTL14‐modified m6A RNA methylation in ocular melanoma

Zhuang A, Gu X, Ge T, Wang S, Ge S, Chai P, Jia R, Fan X
Cancer Communications 2023;43(11):1185-1206

Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells

Li L, Sun Y, Davis A, Shah S, Hamed L, Wu M, Lin C, Ding J, Wang S
Cell Reports 2023;42(6):112596

METTL3-Mediated m6A Modification Controls Splicing Factor Abundance and Contributes to Aggressive CLL

Wu Y, Jin M, Fernandez M, Hart K, Liao A, Ge X, Fernandes S, McDonald T, Chen Z, Röth D, Ghoda L, Marcucci G, Kalkum M, Pillai R, Danilov A, Li J, Chen J, Brown J, Rosen S, Siddiqi T, Wang L
Blood Cancer Discovery 2023;4(3):228-245

METTL14 mediates m6a modification on osteogenic proliferation and differentiation of bone marrow mesenchymal stem cells by regulating the processing of pri-miR-873

Dong X, Liao B, Zhao J, Li X, Yan K, Ren K, Zhang X, Bao X, Guo W
Molecular Medicine Reports 2023;28(3)

Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration

Li Y, Dou X, Liu J, Xiao Y, Zhang Z, Hayes L, Wu R, Fu X, Ye Y, Yang B, Ostrow L, He C, Sun S
Nature Neuroscience 2023;26(8):1328-1338

RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation

Dou X, Xiao Y, Shen C, Wang K, Wu T, Liu C, Li Y, Yu X, Liu J, Dai Q, Pajdzik K, Ye C, Ge R, Gao B, Yu J, Sun S, Chen M, Chen J, He C
Nature Cell Biology 2023;25(9):1359-1368

METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53‐wild‐type cells

Hou Y, Zhang X, Yao H, Hou L, Zhang Q, Tao E, Zhu X, Jiang S, Ren Y, Hong X, Lu S, Leng X, Xie Y, Gao Y, Liang Y, Zhong T, Long B, Fang J, Meng X
EMBO reports 2023;24(4)

METTL3 protects METTL14 from STUB1‐mediated degradation to maintain m6A homeostasis

Zeng Z, Pan Q, Sun Y, Huang H, Chen X, Chen T, He B, Ye H, Zhu S, Pu K, Fang K, Huang W, Chen Y, Wang W
EMBO reports 2023;24(3)

Specific Regulation of m6A by SRSF7 Promotes the Progression of Glioblastoma

Cun Y, An S, Zheng H, Lan J, Chen W, Luo W, Yao C, Li X, Huang X, Sun X, Wu Z, Hu Y, Li Z, Zhang S, Wu G, Yang M, Tang M, Yu R, Liao X, Gao G, Zhao W, Wang J, Li J
Genomics, Proteomics & Bioinformatics 2023;21(4):707-728

Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging

Huang J, Zhou F, Zhou H, Zheng X, Huo Z, Yang M, Xu Z, Liu R, Wang L, Wang X, Gutkind J
PNAS Nexus 2023;2(12)

QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism

Zhao Z, Qing Y, Dong L, Han L, Wu D, Li Y, Li W, Xue J, Zhou K, Sun M, Tan B, Chen Z, Shen C, Gao L, Small A, Wang K, Leung K, Zhang Z, Qin X, Deng X, Xia Q, Su R, Chen J
Cell 2023;186(15):3208-3226.e27

METTL14 suppresses cancer stem cell phenotype of colorectal cancer via regulating of β-catenin/NANOG

Sun C, Chen J, Xing Z, Tao G
Journal of Cancer 2023;14(8):1407-1416

N6-methyladenosine of Spi2a attenuates inflammation and sepsis-associated myocardial dysfunction in mice

Wang X, Ding Y, Li R, Zhang R, Ge X, Gao R, Wang M, Huang Y, Zhang F, Zhao B, Liao W, Du J
Nature Communications 2023;14(1)

Comprehensive immunohistochemical analysis of N6-methyladenosine (m6A) writers, erasers, and readers in endometrial cancer.

Ralser DJ, Condic M, Klümper N, Ellinger J, Staerk C, Egger EK, Kristiansen G, Mustea A, Thiesler T
Journal of cancer research and clinical oncology 2023 Jun;149(6):2417-2424

Hepatitis B Virus X Protein Expression Is Tightly Regulated by N6-Methyladenosine Modification of Its mRNA

Kim G, Siddiqui A, James Ou J
Journal of Virology 2022;96(4)

N 6 -Methyladenine Modification of Hepatitis Delta Virus Regulates Its Virion Assembly by Recruiting YTHDF1

Kim G, Moon J, Gudima S, Siddiqui A, Ou J
Journal of Virology 2022;96(19)

METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma

Li H, Huang G, Tu J, Lv D, Jin Q, Chen J, Zou Y, Lee D, Shen J, Xie X
eBioMedicine 2022;82

m 6 A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB–mediated antiapoptotic pathway

Zhang T, Ding C, Chen H, Zhao J, Chen Z, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M, Flavell R, Li H
Science Advances 2022;8(12)

METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism

Wang Y, Chen J, Gao W, Yang R
Cell Death Discovery 2022;8(1)

Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice

Pupak A, Singh A, Sancho-Balsells A, Alcalá-Vida R, Espina M, Giralt A, Martí E, Ørom U, Ginés S, Brito V
Cellular and Molecular Life Sciences 2022;79(8)

m6A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration

Liu Y, Song R, Zhao L, Lu Z, Li Y, Zhan X, Lu F, Yang J, Niu Y, Cao X
Signal Transduction and Targeted Therapy 2022;7(1)

FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression

McFadden M, Sacco M, Murphy K, Park M, Gokhale N, Somfleth K, Horner S
Journal of Molecular Biology 2022;434(6):167247

METTL14-mediated Lnc-LSG1 m6A modification inhibits clear cell renal cell carcinoma metastasis via regulating ESRP2 ubiquitination

Shen D, Ding L, Lu Z, Wang R, Yu C, Wang H, Zheng Q, Wang X, Xu W, Yu H, Xu L, Wang M, Yu S, Zhu S, Qian J, Xia L, Li G
Molecular Therapy - Nucleic Acids 2022;27

METTL14 promotes migration and invasion of choroidal melanoma by targeting RUNX2 mRNA via m6A modification

Zhang X, Zhang X, Liu T, Zhang Z, Piao C, Ning H
Journal of Cellular and Molecular Medicine 2022;26(22):5602-5613

m6A regulation of cortical and retinal neurogenesis is mediated by the redundant m6A readers YTHDFs

Niu F, Che P, Yang Z, Zhang J, Yang L, Zhuang M, Ou X, Ji S
iScience 2022;25(9):104908

METTL16 exerts an m6A-independent function to facilitate translation and tumorigenesis

Su R, Dong L, Li Y, Gao M, He P, Liu W, Wei J, Zhao Z, Gao L, Han L, Deng X, Li C, Prince E, Tan B, Qing Y, Qin X, Shen C, Xue M, Zhou K, Chen Z, Xue J, Li W, Qin H, Wu X, Sun M, Nam Y, Chen C, Huang W, Horne D, Rosen S, He C, Chen J
Nature Cell Biology 2022;24(2):205-216

A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells

Coller J, Porman A, Roberts J, Duncan E, Chrupcala M, Levine A, Kennedy M, Williams M, Richer J, Johnson A
PLOS Biology 2022;20(11):e3001885

Epitranscriptome profiling of spleen mRNA m6A methylation reveals pathways of host responses to malaria parasite infection

Wang L, Wu J, Liu R, Chen W, Pang Z, Zhou F, Xia L, Huang J, Pan T, Su X, Wang X
Frontiers in Immunology 2022;13

N6-methyladenosine modification of the 5′ epsilon structure of the HBV pregenome RNA regulates its encapsidation by the viral core protein

Kim G, Moon J, Siddiqui A
Proceedings of the National Academy of Sciences 2022;119(7)

m6A modifications regulate intestinal immunity and rotavirus infection

Wang A, Tao W, Tong J, Gao J, Wang J, Hou G, Qian C, Zhang G, Li R, Wang D, Ren X, Zhang K, Ding S, Flavell R, Li H, Pan W, Zhu S
eLife 2022;11

m6A Modification Involves in Enriched Environment-Induced Neurogenesis and Cognition Enhancement

Qu W, Li Q, Wang M, Zhao X, Wu J, Liu D, Hong S, Yang Y, Shu Q, Li X
Frontiers in Cell and Developmental Biology 2022;10

The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine

Xiao Z, Liu S, Li Z, Cui J, Wang H, Wang Z, Ren Q, Xia L, Wang Z, Li Y
Frontiers in Cell and Developmental Biology 2022;10

Exercise training ameliorates myocardial phenotypes in heart failure with preserved ejection fraction by changing N6-methyladenosine modification in mice model

Liu K, Ju W, Ouyang S, Liu Z, He F, hao J, Guan H, Wu J
Frontiers in Cell and Developmental Biology 2022;10

N6-methyladenosine RNA modification (m6A) is of prognostic value in HPV-dependent vulvar squamous cell carcinoma.

Condic M, Thiesler T, Staerk C, Klümper N, Ellinger J, Egger EK, Kübler K, Kristiansen G, Mustea A, Ralser DJ
BMC cancer 2022 Sep 1;22(1):943

Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration

Xie S, Lei H, Yang B, Diao L, Liao J, He J, Tao S, Hu Y, Hou Y, Sun Y, Peng Y, Zhang Q, Xiao Z
Frontiers in Cell and Developmental Biology 2021;9

Characterization of Long Non-coding RNAs Modified by m6A RNA Methylation in Skeletal Myogenesis

Xie S, Tao S, Diao L, Li P, Chen W, Zhou Z, Hu Y, Hou Y, Lei H, Xu W, Chen W, Peng Y, Zhang Q, Xiao Z
Frontiers in Cell and Developmental Biology 2021;9

Relaxed initiation pausing of ribosomes drives oncogenic translation

Dong L, Mao Y, Zhou A, Liu X, Zhou J, Wan J, Qian S
Science Advances 2021;7(8)

Regulation of telomere homeostasis and genomic stability in cancer by N 6 -adenosine methylation (m 6 A)

Lee J, Hong J, Zhang Z, de la Peña Avalos B, Proietti C, Deamicis A, Guzmán G. P, Lam H, Garcia J, Roudier M, Sisk A, De La Rosa R, Vu K, Yang M, Liao Y, Scheirer J, Pechacek D, Yadav P, Rao M, Zheng S, Johnson-Pais T, Leach R, Elizalde P, Dray E, Xu K
Science Advances 2021;7(31)

Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response

Yu F, Wei J, Cui X, Yu C, Ni W, Bungert J, Wu L, He C, Qian Z
Nucleic Acids Research 2021;49(10):5779-5797

m 6 A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region

Wang Z, Pan Z, Adhikari S, Harada B, Shen L, Yuan W, Abeywardana T, Al‐Hadid Q, Stark J, He C, Lin L, Yang Y
The EMBO Journal 2021;40(5)

Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine

McFadden M, McIntyre A, Mourelatos H, Abell N, Gokhale N, Ipas H, Xhemalçe B, Mason C, Horner S
Cell Reports 2021;34(9):108798

A methionine-Mettl3-N-methyladenosine axis promotes polycystic kidney disease

Ramalingam H, Kashyap S, Cobo-Stark P, Flaten A, Chang C, Hajarnis S, Hein K, Lika J, Warner G, Espindola-Netto J, Kumar A, Kanchwala M, Xing C, Chini E, Patel V
Cell Metabolism 2021;33(6):1234-1247.e7

Conditional deficiency of m6A methyltransferase Mettl14 in substantia nigra alters dopaminergic neuron function

Teng Y, Liu Z, Chen X, Liu Y, Geng F, Le W, Jiang H, Yang L
Journal of Cellular and Molecular Medicine 2021;25(17):8567-8572

m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype

Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov A, Simon M, Zhang R
Nature Cell Biology 2021;23(4):355-365

MYC promotes cancer progression by modulating m6A modifications to suppress target gene translation

Wu G, Suo C, Yang Y, Shen S, Sun L, Li S, Zhou Y, Yang D, Wang Y, Cai Y, Wang N, Zhang H, Yang Y, Cao J, Gao P
EMBO reports 2021;22(3)

N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages

Evans D, Chen S, Kumar S, Espada C, Tirumuru N, Cahill M, Hu L, He C, Wu L
PLOS Pathogens 2021;17(3):e1009421

Mettl14-Mediated m6A Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis

Cao X, Shu Y, Chen Y, Xu Q, Guo G, Wu Z, Shao M, Zhou Y, Chen M, Gong Y, Li C, Shi Y, Bu H
Cellular and Molecular Gastroenterology and Hepatology 2021;12(2):633-651

METTL14 aggravates podocyte injury and glomerulopathy progression through N6-methyladenosine-dependent downregulating of Sirt1

Lu Z, Liu H, Song N, Liang Y, Zhu J, Chen J, Ning Y, Hu J, Fang Y, Teng J, Zou J, Dai Y, Ding X
Cell Death & Disease 2021;12(10)

Arginine methylation of METTL14 promotes RNA N6-methyladenosine modification and endoderm differentiation of mouse embryonic stem cells

Liu X, Wang H, Zhao X, Luo Q, Wang Q, Tan K, Wang Z, Jiang J, Cui J, Du E, Xia L, Du W, Chen D, Xia L, Xiao S
Nature Communications 2021;12(1)

N6-methyladenosine (m 6 A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells

Jin K, Zuo R, Anastassiadis K, Klungland A, Marr C, Filipczyk A
Proceedings of the National Academy of Sciences 2021;118(51)

N6-methyladenosine modification of HCV RNA genome regulates cap-independent IRES-mediated translation via YTHDC2 recognition

Kim G, Siddiqui A
Proceedings of the National Academy of Sciences 2021;118(10)

Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.

Wang YJ, Yang B, Lai Q, Shi JF, Peng JY, Zhang Y, Hu KS, Li YQ, Peng JW, Yang ZZ, Li YT, Pan Y, Koeffler HP, Liao JY, Yin D
RNA biology 2021 Jan;18(1):131-143

Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease

Huang H, Camats-Perna J, Medeiros R, Anggono V, Widagdo J
eneuro 2020;7(5):ENEURO.0125-20.2020

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA

Wu Z, Shi Y, Lu M, Song M, Yu Z, Wang J, Wang S, Ren J, Yang Y, Liu G, Zhang W, Ci W, Qu J
Nucleic Acids Research 2020;48(19):11083-11096

The m6A methyltransferase METTL14 inhibits the proliferation, migration, and invasion of gastric cancer by regulating the PI3K/AKT/mTOR signaling pathway

Liu X, Xiao M, Zhang L, Li L, Zhu G, Shen E, Lv M, Lu X, Sun Z
Journal of Clinical Laboratory Analysis 2020;35(3)

N6-Methyladenosine modification of hepatitis B and C viral RNAs attenuates host innate immunity via RIG-I signaling

Kim G, Imam H, Khan M, Siddiqui A
Journal of Biological Chemistry 2020;295(37):13123-13133

m6A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells

Chen Y, Wang J, Xu D, Xiang Z, Ding J, Yang X, Li D, Han X
Autophagy 2020;17(2):457-475

Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver

Jabs S, Biton A, Bécavin C, Nahori M, Ghozlane A, Pagliuso A, Spanò G, Guérineau V, Touboul D, Giai Gianetto Q, Chaze T, Matondo M, Dillies M, Cossart P
Nature Communications 2020;11(1)

Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

Price A, Hayer K, McIntyre A, Gokhale N, Abebe J, Della Fera A, Mason C, Horner S, Wilson A, Depledge D, Weitzman M
Nature Communications 2020;11(1)

m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

Xu H, Dzhashiashvili Y, Shah A, Kunjamma R, Weng Y, Elbaz B, Fei Q, Jones J, Li Y, Zhuang X, Ming G, He C, Popko B
Neuron 2020;105(2):293-309.e5

m6A Reader YTHDC2 Promotes Radiotherapy Resistance of Nasopharyngeal Carcinoma via Activating IGF1R/AKT/S6 Signaling Axis

He J, Li Z, Rong Z, Gao J, Mu Y, Guan Y, Ren X, Zi Y, Liu L, Fan Q, Zhou M, Duan Y, Zhou Q, Deng Y, Sun L
Frontiers in Oncology 2020;10

m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2

Chen J, Zhang Y, Huang C, Shen H, Sun B, Cheng X, Zhang Y, Yang Y, Shu Q, Yang Y, Li X
Genomics, Proteomics & Bioinformatics 2019;17(2):154-168

METTL3 and ALKBH5 oppositely regulate m6A modification of TFEB mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes

Song H, Feng X, Zhang H, Luo Y, Huang J, Lin M, Jin J, Ding X, Wu S, Huang H, Yu T, Zhang M, Hong H, Yao S, Zhao Y, Zhang Z
Autophagy 2019;15(8):1419-1437

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Wang H, Hu X, Huang M, Liu J, Gu Y, Ma L, Zhou Q, Cao X
Nature Communications 2019;10(1)

m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2

Mao Y, Dong L, Liu X, Guo J, Ma H, Shen B, Qian S
Nature Communications 2019;10(1)

m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes

De Jesus D, Zhang Z, Kahraman S, Brown N, Chen M, Hu J, Gupta M, He C, Kulkarni R
Nature Metabolism 2019;1(8):765-774

Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning

Koranda J, Dore L, Shi H, Patel M, Vaasjo L, Rao M, Chen K, Lu Z, Yi Y, Chi W, He C, Zhuang X
Neuron 2018;99(2):283-292.e5

METTL3 regulates WTAP protein homeostasis

Sorci M, Ianniello Z, Cruciani S, Larivera S, Ginistrelli L, Capuano E, Marchioni M, Fazi F, Fatica A
Cell Death & Disease 2018;9(8)

The m6A-methylase complex recruits TREX and regulates mRNA export

Lesbirel S, Viphakone N, Parker M, Parker J, Heath C, Sudbery I, Wilson S
Scientific Reports 2018;8(1)

N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response

Zhou J, Wan J, Shu X, Mao Y, Liu X, Yuan X, Zhang X, Hess M, Brüning J, Qian S
Molecular Cell 2018;69(4):636-647.e7

Dynamic m6A modification regulates local translation of mRNA in axons

Yu J, Chen M, Huang H, Zhu J, Song H, Zhu J, Park J, Ji S
Nucleic Acids Research 2018;46(3):1412-1423

Cross-talk among writers, readers, and erasers of m 6 A regulates cancer growth and progression

Panneerdoss S, Eedunuri V, Yadav P, Timilsina S, Rajamanickam S, Viswanadhapalli S, Abdelfattah N, Onyeagucha B, Cui X, Lai Z, Mohammad T, Gupta Y, Huang T, Huang Y, Chen Y, Rao M
Science Advances 2018;4(10)

METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

Weng H, Huang H, Wu H, Qin X, Zhao B, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore L, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy J, Yang J, Qian Z, Wei M, He C, Chen J
Cell Stem Cell 2018;22(2):191-205.e9

N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

Wang Y, Li Y, Yue M, Wang J, Kumar S, Wechsler-Reya R, Zhang Z, Ogawa Y, Kellis M, Duester G, Zhao J
Nature Neuroscience 2018;21(2):195-206

METTL3-mediated m6A modification is required for cerebellar development.

Wang CX, Cui GS, Liu X, Xu K, Wang M, Zhang XX, Jiang LY, Li A, Yang Y, Lai WY, Sun BF, Jiang GB, Wang HL, Tong WM, Li W, Wang XJ, Yang YG, Zhou Q
PLoS biology 2018 Jun;16(6):e2004880

Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets

Zhang F, Kang Y, Wang M, Li Y, Xu T, Yang W, Song H, Wu H, Shu Q, Jin P
Human Molecular Genetics 2018

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

Liu N, Zhou K, Parisien M, Dai Q, Diatchenko L, Pan T
Nucleic Acids Research 2017;45(10):6051-6063

Viral and cellular N6-methyladenosine and N6,2′-O-dimethyladenosine epitranscriptomes in the KSHV life cycle

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