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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [207]
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- Product number
- 26158-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#26158-1-AP, RRID:AB_2800447
- Product name
- METTL14 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated METTL14 antibody (Cat. #26158-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Domain associated with zinc fingers-containing NF90-NF45 complex inhibits m(6)A modification of primary microRNA by suppressing METTL3/14 activity.
BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer-Associated Fibroblasts Crosstalk.
YTHDF2 promotes arsenic carcinogenesis through m(6)A-dependent SMAD7 decay and PRR5 escape from decay.
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
Elevated m(6)A RNA modifications associate with immune dysregulation and cancer in people with HIV-1.
N(6)-methyladenosine modification of MRP7 mRNA modulates its expression and paclitaxel sensitivity in lung cancer-derived A549 cells.
N(6)-methyladenosine attenuates tumor-associated macrophages M2 polarization via suppressing the translation of Snail.
METTL14 Inhibits Human Lung Microvascular Endothelial Cell From Ferroptosis in Septic Lung Injury by Regulating N(6)-Methyladenosine-Modified ACSL4 Level.
m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.
PRKN-Mediated Ubiquitin-Proteasome Degradation of METTL3 Promotes Cellular Senescence.
METTL14 Promotes Lipid Synthesis in Dairy Goat Mammary Epithelial Cells by Targeting CEBPB via m6A-YTHDF1/3-Dependent Manner.
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
Methyltransferase-like 14 suppresses the retinal neovascularization by reducing HIF-1α in proliferative retinopathy.
HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5.
Cherry plum powder alleviates excessive proliferation and inflammation of keratinocytes in psoriasis by reducing N6 methyladenosine-modified S100A4.
METTL14 deficiency impairs chondrogenic differentiation via m6A-dependent TRAF4 mRNA regulation in Kashin-Beck disease.
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
METTL14 alleviates heat stress in Hu sheep involves enhancing fatty acid oxidation while reducing lipid deposition.
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
METTL14 promotes TBK1 mRNA stability through IGF2BP3-recognized m6A modification and enhances mitophagy in BMSCs.
H3K36me3-Guided m(6)A Modification of Oncogenic L1CAM-AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma.
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
Glycyrrhizic Acid Ameliorates LPS-Induced WI-38 Cell Inflammation, Oxidative Stress, and Ferroptosis via Targeting METTL14 in Infantile Pneumonia.
3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay.
M6A-mediated uc003pes.1 stability regulates proliferation and migration of human coronary artery smooth muscle cells via scaffolding STAT1 and USP10.
IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.
PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA.
WTAP-mediated m(6)A modification promotes drug sensitivity by regulating NR3C1 in prostate cancer.
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
Effect of berberine on LPS-induced intestinal epithelial injury and m(6)A methylation in broilers.
IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation.
DNA topoisomerase II promotes N(6)-adenosine mRNA methylation.
MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction.
Methyltransferase-like enzyme 14 exacerbates retinal ganglion cell damage and diabetic retinopathy through N6-methyladenosine-dependent upregulation of pleckstrin homology domain and leucine rich repeat protein phosphatase 2.
YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response.
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.
Edaravone inhibits neuronal ferroptosis and alleviates acute Central nervous system injury induced by diquat via enhancement of METTL14-mediated m6A methylation of Aldh1l1.
Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway.
METTL14-mediated m6A modification of TRPA1 promotes acute visceral pain induced by uterine cervical dilation by promoting NR2B phosphorylation.
Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence.
Mitigation of Ferroptosis in Diabetic Kidney Disease Through Mesenchymal Stem Cell Intervention via the Smad2/3/METTL3/S1PR1 Axis.
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.
The m(6)A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia.
Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer.
IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression.
The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.
ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.
N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.
Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibrosis by bringing about epithelial-mesenchymal transition.
AQP3 Influences Unexplained Recurrent Abortion by Regulating Trophoblast Cell Migration and Invasion via the METTL14/IGF2BP1/AQP3/PI3K/AKT Pathway.
METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
METTL14 promotes ferroptosis during the development of cisplatin-induced kidney injury by stabilizing ERFE through IGF2BP3-dependent m(6)A methylation.
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Influenza NS1 drives N(6)-methyladenosine (m(6)A)-mediated autoregulation of viral mRNA splicing.
SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication.
TRMU Confers Resistance of Melanoma Cells to Vemurafenib through Modulating Mitochondrial Activities.
The METTL3-YTHDC1 axis mediates architectural RNA m(6)A modification to modulate the integrity of chromatin TADs in MLLr + AML genome.
Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m(6)A RNA methylation.
USP25 deubiquitinates cytosolic METTL3 to impede glioma proliferation via an m6A-independent pathway.
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
SETD2 drives METTL14-mediated m(6)A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension.
Treponema pallidum lipoprotein TpF1 regulates METTL14-mediated NF-κB signaling pathway to promote macrophage M2 polarization.
Phospholipase Cε1 activates Rap1 signaling pathway to promote proliferation, EMT and angiogenesis of choriocarcinoma cells.
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.
N6-Methyladenosine-Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification.
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
RNA Methylation and Transcriptome Analysis Reveal Key Regulatory Pathways Related to Cadmium-Induced Liver Damage.
Thiamine and METTL14 in Diabetes Management with Intensive Insulin Therapy.
N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.
Dexmedetomidine improves mitophagy and pyroptosis through the ALKBH5/FUNDC1 axis during epidural-related maternal fever.
H3K36 methyltransferase SMYD2 affects cell proliferation and migration in Hirschsprung's disease by regulating METTL3.
METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress.
METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma.
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.
Zinc finger protein 180 induces an apoptotic phenotype by activating METTL14 transcriptional activity in colorectal cancer.
METTL14-mediated N6-methyladenosine modification of TCP1 mRNA promotes acute myeloid leukemia progression.
Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4.
Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11.
TGF-β Promotes Hepatocellular Carcinoma Metastasis Through Through m6A Modification of PCDHGA9.
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Epitranscriptomic m(6)A modifications during reactivation of HIV-1 latency in CD4(+) T cells.
METTL14-mediated m6A methylation regulates pathological retinal neovascularization by targeting autophagy.
METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m(6)A-dependent manner.
Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.
IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis.
Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis.
Classical swine fever virus non-structural protein 5B hijacks host METTL14-mediated m6A modification to counteract host antiviral immune response.
HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to promote neuroblastoma progression.
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.
Landscape of transcriptome-wide m(6)A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise.
CircUGGT2 downregulation by METTL14-dependent m(6)A modification suppresses gastric cancer progression and cisplatin resistance through interaction with miR-186-3p/MAP3K9 axis.
Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2.
m6A-Mediated IRS1 Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling.
Characterization of m6A Modifiers and RNA Modifications in Uterine Fibroids.
METTL3 and METTL14 regulate IL-6 expression via RNA m6A modification of zinc transporter SLC39A9 and DNA methylation of IL-6 in periodontal ligament cells.
Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.
Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.
FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.
METTL14 enhances the m6A modification level of lncRNA MSTRG.292666.16 to promote the progression of non-small cell lung cancer.
The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability.
The m(6)A modification of ACSL4 mRNA sensitized esophageal squamous cell carcinoma to irradiation via accelerating ferroptosis.
HNRNPH1 stabilizes FLOT2 mRNA in a non-canonical m6A-dependent manner to promote malignant progression in nasopharyngeal carcinoma.
METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
piR-27222 mediates PM(2.5)-induced lung cancer by resisting cell PANoptosis through the WTAP/m(6)A axis.
Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1.
Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9-mediated inhibition of N6-methyladenosine demethylase FTO.
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
METTL14 Regulates PLAGL2/β-Catenin Signaling Axis to Promote the Development of Nonsmall Cell Lung Cancer.
Suppression of Wnt/β-catenin Signaling in PDAC via METTL16-mediated N6-methyladenosine Modification of DVL2.
IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer.
Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.
HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Mettl3 induced miR-338-3p expression in dendritic cells promotes antigen-specific Th17 cell response via regulation of Dusp16.
Macrophage membrane-coated nanovesicles for dual-targeted drug delivery to inhibit tumor and induce macrophage polarization.
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells.
Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating NEAT1 Through N6-Methyladenosine Modifications.
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.
ALKBH1-mediated m(1) A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
m (6) A RNA methylation orchestrates transcriptional dormancy during developmental pausing.
Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.
METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis.
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
Coilin mediates m6A RNA methylation through phosphorylation of METTL3.
Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma.
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.
Characterization of m(6)A modifiers and RNA modifications in uterine fibroids.
Smoking and tetramer tryptase accelerate intervertebral disc degeneration by inducing METTL14-mediated DIXDC1 m(6) modification.
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury.
METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.
Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m(6)A-modified long non-coding RNAs in lung adenocarcinoma.
METTL14 Regulates Intestine Cellular Senescence through m(6)A Modification of Lamin B Receptor.
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Adenosine N(6)-methylation upregulates the expression of human CYP2B6 by altering the chromatin status.
Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.
N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.
Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant m6A RNA modification in head and neck squamous cell carcinoma.
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers.
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
Mechanism of METTL14-mediated m(6)A modification in non-small cell lung cancer cell resistance to cisplatin.
The landscape of m6A regulators in esophageal cancer: molecular characteristics, immuno-oncology features, and clinical relevance.
PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing's sarcoma.
Mettl14-Mediated m6A Modification Is Essential for Germinal Center B Cell Response.
Methylation and Expression of the Exercise-Related TLR1 Gene Is Associated With Low Grade Glioma Prognosis and Outcome.
MMP24 Contributes to Neuropathic Pain in an FTO-Dependent Manner in the Spinal Cord Neurons.
Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer.
Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.
M6A "Writer" Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer.
m(6)A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.
Isorhapontigenin (ISO) inhibits EMT through FOXO3A/METTL14/VIMENTIN pathway in bladder cancer cells.
mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.
Knockdown of METTL14 suppresses the malignant progression of non-small cell lung cancer by reducing Twist expression.
YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.
ALKBH5-mediated m(6)A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling.
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
The m(6)A methylome of SARS-CoV-2 in host cells.
METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.
METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications.
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA.
Analysis of METTL3 and METTL14 in hepatocellular carcinoma.
ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
Alteration of N(6)-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy.
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
m(6)A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.
AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.
EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.
Epitranscriptomic m(6)A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Higuchi T, Morioka S, Morisawa K, Matsukawa K, Ashida S, Suzuki T, Sakamoto S
FEBS open bio 2026 May;16(5):921-931
FEBS open bio 2026 May;16(5):921-931
BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer-Associated Fibroblasts Crosstalk.
Shi HZ, Wu MY, Liu JQ, Tian C, Ma L, Zhou XM, Sun ZH, Xu ZY, Zhang RD, Ye SY, Huang LM, Wang Y, Xiong JS, Bu WB, Cheng XF, Sun JF, Chen H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(28):e14590
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(28):e14590
YTHDF2 promotes arsenic carcinogenesis through m(6)A-dependent SMAD7 decay and PRR5 escape from decay.
Zhang Q, Man J, Cai J, Zhao T, Zhang Z
International journal of biological macromolecules 2026 Mar;348:150816
International journal of biological macromolecules 2026 Mar;348:150816
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
Qin W, Wei J, Li F, Wang L, Zhang Q, Chen J, Lu P, Long T, Liu A, Cao J, Deng Y, Zhang H, Chen D, Cui J, Zhao W
Cell reports 2026 Mar 24;45(3):116993
Cell reports 2026 Mar 24;45(3):116993
Elevated m(6)A RNA modifications associate with immune dysregulation and cancer in people with HIV-1.
Mishra T, Tripathi S, Stapleton JT, Wu L
BMC cancer 2026 Mar 21;26(1)
BMC cancer 2026 Mar 21;26(1)
N(6)-methyladenosine modification of MRP7 mRNA modulates its expression and paclitaxel sensitivity in lung cancer-derived A549 cells.
Inamoto T, Nakano M, Fukami T, Nakajima M
Drug metabolism and pharmacokinetics 2026 Jun;68:101519
Drug metabolism and pharmacokinetics 2026 Jun;68:101519
N(6)-methyladenosine attenuates tumor-associated macrophages M2 polarization via suppressing the translation of Snail.
Tian Y, Peng J, Zhou J, Yang W, Peng Y, Li J, Rui Y, Zhang H, Xie G, Wang H, Wang J, Li J, Huang Z, Ma X, Wang H, He J
Science China. Life sciences 2026 Jan;69(1):119-135
Science China. Life sciences 2026 Jan;69(1):119-135
METTL14 Inhibits Human Lung Microvascular Endothelial Cell From Ferroptosis in Septic Lung Injury by Regulating N(6)-Methyladenosine-Modified ACSL4 Level.
Gui X, Tian Y, Zhu H, Wang L, Wang J, Wu R, Gan F
Clinical and experimental pharmacology & physiology 2026 Jan;53(1):e70095
Clinical and experimental pharmacology & physiology 2026 Jan;53(1):e70095
m(6)A modification in the 3'‑leader region of EBOV genome antagonizes ISG20 to facilitate viral replication.
Zhao B, Cao Z, Zhang K, Xiao S, Shen X, Li F, Wu Y, Zhang B, Wang Q, Zhang H, Chuai X, Chiu S
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804
International journal of biological macromolecules 2026 Jan;339(Pt 2):149804
PRKN-Mediated Ubiquitin-Proteasome Degradation of METTL3 Promotes Cellular Senescence.
Chen L, Zhang C, Ge Y, Zhou H, Yang S, Wei W, Zhou Q, Xiao K, Huang G, Li X, Wang J, Zheng J, Gu R, Ju Z, Wu S
Aging cell 2026 Jan;25(1):e70347
Aging cell 2026 Jan;25(1):e70347
METTL14 Promotes Lipid Synthesis in Dairy Goat Mammary Epithelial Cells by Targeting CEBPB via m6A-YTHDF1/3-Dependent Manner.
Jiao H, Zhu L, Tang X, Gong P, Wang W, Liu B, Luo J
Animals : an open access journal from MDPI 2026 Jan 8;16(2)
Animals : an open access journal from MDPI 2026 Jan 8;16(2)
Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m(6)A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.
Du J, Li C, Zhang J, Luo J, Zhang H, Chen H, Li X, Qian P
Cell & bioscience 2026 Jan 4;16(1):13
Cell & bioscience 2026 Jan 4;16(1):13
Methyltransferase-like 14 suppresses the retinal neovascularization by reducing HIF-1α in proliferative retinopathy.
Guan J, Wang X, Huang Z, Zhang X, Hu Q, Sang W, Jiang B, Sun D
European journal of medical research 2026 Jan 30;31(1)
European journal of medical research 2026 Jan 30;31(1)
HIV-1 Vpr activates microglia by upregulating m6A modification through ubiquitin-proteasome pathway-mediated degradation of the demethylase ALKBH5.
Peng Q, Li W, Qian F, Zhu Y, Hu S, Shi Y, Xia Y, Liu W, Shu X, Wan P, Liu Y, Sun B
Virulence 2026 Dec;17(1):2645908
Virulence 2026 Dec;17(1):2645908
Cherry plum powder alleviates excessive proliferation and inflammation of keratinocytes in psoriasis by reducing N6 methyladenosine-modified S100A4.
Wang H, Ding Y, Yu S, Wu W
Journal of molecular histology 2026 Apr 29;57(3)
Journal of molecular histology 2026 Apr 29;57(3)
METTL14 deficiency impairs chondrogenic differentiation via m6A-dependent TRAF4 mRNA regulation in Kashin-Beck disease.
Zhang Q, Naren G, Zhang J, Yang P, Deng X, Niu H, Liu H, Wu C
International immunopharmacology 2026 Apr 15;175:116409
International immunopharmacology 2026 Apr 15;175:116409
The m6A modification of SOX18 leads to increased PTX3 and cardiomyocyte pyroptosis in sepsis-induced cardiomyopathy.
Sun H, Qiao X, Peng X, Zhu H, Zhang L, Jiang L, Wang L, Xue C, Yang J, Yi W, Zhang B, Liu J, Duan W
Theranostics 2025;15(8):3532-3550
Theranostics 2025;15(8):3532-3550
METTL14 alleviates heat stress in Hu sheep involves enhancing fatty acid oxidation while reducing lipid deposition.
Chen B, Yuan C, Guo T, Sun L, Liu J, Lu Z
Frontiers in veterinary science 2025;12:1732947
Frontiers in veterinary science 2025;12:1732947
METTL3 Silencing Suppresses Cardiac Fibrosis Post Myocardial Infarction via m6A Modification of SMOC2.
He Y, Pan X, Liu Z, Zuo P, Sheng Z, Hao C, Tao Z, Chen Z, Song J, Ma G, Ling S
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
Journal of cellular and molecular medicine 2025 Sep;29(17):e70829
METTL14 promotes TBK1 mRNA stability through IGF2BP3-recognized m6A modification and enhances mitophagy in BMSCs.
Shen Y, Wang L, Guo Z, Wang J, Zhang R, Tang C, Wu J
Cellular signalling 2025 Sep;133:111873
Cellular signalling 2025 Sep;133:111873
H3K36me3-Guided m(6)A Modification of Oncogenic L1CAM-AS1 Drives Macrophage Polarization and Immunotherapy Resistance in Hepatocellular Carcinoma.
Wang T, Han L, Huo Y, Zhang L, Huang Y, Zhang N, Yang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e14909
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(33):e14909
RBM15-mediated m6A methylation of Entpd1/CD39 regulates extracellular ATP hydrolysis and alleviates myocardial ischemia-reperfusion injury.
Yan Z, Cao H, Zhang X, Wang Y, Chang Q
International immunopharmacology 2025 Sep 23;162:115141
International immunopharmacology 2025 Sep 23;162:115141
Glycyrrhizic Acid Ameliorates LPS-Induced WI-38 Cell Inflammation, Oxidative Stress, and Ferroptosis via Targeting METTL14 in Infantile Pneumonia.
Xie X, Wang C, Sun Y, Sun T, Song Y, Wang N, Wang Z, Wang Y
Clinical and experimental pharmacology & physiology 2025 Oct;52(10):e70068
Clinical and experimental pharmacology & physiology 2025 Oct;52(10):e70068
3D printing-biomimetic local stiff niche enhances glycolysis to boost PDAC cell stem-like phenotype via N6-methyladenosine-suppressed YAP1 mRNA decay.
Wu D, Guan X, Yang T, Yan J, Zhu B, Zhou J, Guo Y, Lu Y
Materials today. Bio 2025 Oct;34:102176
Materials today. Bio 2025 Oct;34:102176
M6A-mediated uc003pes.1 stability regulates proliferation and migration of human coronary artery smooth muscle cells via scaffolding STAT1 and USP10.
Jiang R, Jia Q, Li C, He S, Zhou H, Ren M, Liang L, Jia E
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120023
Biochimica et biophysica acta. Molecular cell research 2025 Oct;1872(7):120023
IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation.
Sharma G, Gutierrez M, Jones AE, Kapoor S, Jaiswal AK, Neeb ZT, Rios A, Dorairaj P, Thaxton ML, Lin TL, Tran TM, Kabbani LES, Ritter AJ, Scherer GM, Sorrentino JP, Stiles L, Hoeve JT, Damoiseaux RD, Garg NK, Divakaruni AS, Sanford JR, Rao DS
Cell reports 2025 Oct 28;44(10):116330
Cell reports 2025 Oct 28;44(10):116330
PCBP2 Mediates Olaparib Resistance in Breast Cancer by Inhibiting m6A Methylation to Stabilize PARP1 mRNA.
Qi Z, He L, Xu Z, Luo X, Ji L, Lin C, Giuliano AE, Cui X, Deng Z, Wu J, Lin SL, Cui Y
Cancer research 2025 Oct 15;85(20):3949-3965
Cancer research 2025 Oct 15;85(20):3949-3965
WTAP-mediated m(6)A modification promotes drug sensitivity by regulating NR3C1 in prostate cancer.
Wang H, Zhang D, Ouyang Y, Li J, Pang G, Xie X, Huang H, Yan T, Pang X, Zhou Q, Xie B, Wang F, An S, Hu Y
Science China. Life sciences 2025 Nov;68(11):3151-3166
Science China. Life sciences 2025 Nov;68(11):3151-3166
Gambogic acid induces ferroptosis and suppresses colorectal cancer progression by modulating the m6A modification of p62.
Wang J, Deng J, Sun B, Qiao G, Yang J, Gao Z, Zhang Q, Dong M, Qu P, Wang Z
Cellular signalling 2025 Nov;135:112024
Cellular signalling 2025 Nov;135:112024
Effect of berberine on LPS-induced intestinal epithelial injury and m(6)A methylation in broilers.
Yuan L, Li W, Li G, Jin W, Wang B, Li S, Wang H
Poultry science 2025 Nov;104(11):105677
Poultry science 2025 Nov;104(11):105677
IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation.
Xiong X, Wang X, Wang Z, Chen F, Shi Y, Chen X, Gong W, Jia X, Xu J
Cell reports 2025 Nov 25;44(11):116511
Cell reports 2025 Nov 25;44(11):116511
DNA topoisomerase II promotes N(6)-adenosine mRNA methylation.
Megías-Fernández C, Delgado-Sainz I, León-Halcón A, Buglioni V, Bruno F, González-Aguilera C, Maslon MM, Jimeno-González S
Cell reports 2025 Nov 25;44(11):116468
Cell reports 2025 Nov 25;44(11):116468
MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction.
Zhou H, Gong H, Zeng X, Zeng C, Liu D, Liu J, Zhang Y
International journal of molecular medicine 2025 May;55(5)
International journal of molecular medicine 2025 May;55(5)
Methyltransferase-like enzyme 14 exacerbates retinal ganglion cell damage and diabetic retinopathy through N6-methyladenosine-dependent upregulation of pleckstrin homology domain and leucine rich repeat protein phosphatase 2.
Chen L, Wei T, Liu X, Cui L, Hu C, Quan Y
Toxicology and applied pharmacology 2025 May;498:117304
Toxicology and applied pharmacology 2025 May;498:117304
YTHDF1 shapes immune-mediated hepatitis via regulating inflammatory cell recruitment and response.
Li H, Yu K, Zhang X, Li J, Hu H, Deng X, Zeng S, Dong X, Zhao J, Zhang Y
Genes & diseases 2025 May;12(3):101327
Genes & diseases 2025 May;12(3):101327
Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia.
Miller C, Ealy A, Gregory A, Janarthanam C, Albers W, Richardson G, Jin H, Zenitsky G, Anantharam V, Kanthasamy A, Kanthasamy AG
Cell reports 2025 May 27;44(5):115618
Cell reports 2025 May 27;44(5):115618
Edaravone inhibits neuronal ferroptosis and alleviates acute Central nervous system injury induced by diquat via enhancement of METTL14-mediated m6A methylation of Aldh1l1.
Wu L, Luo Z, Luo F, Huang T, Cen Y, Rao G, Zhao Z, Ou R, Zhou M
Free radical research 2025 Mar;59(3):274-288
Free radical research 2025 Mar;59(3):274-288
Trimethylamine N-oxide aggravates human aortic valve interstitial cell inflammation by regulating the macrophages polarization through a N6-methyladenosine-mediated pathway.
Wen L, Lin X, Hu D, Li J, Xie K, Li S, Su S, Duan X, Zhong G, Lin Y, Chen Y, Xu T, Zeng Q
Atherosclerosis 2025 Mar;402:119109
Atherosclerosis 2025 Mar;402:119109
METTL14-mediated m6A modification of TRPA1 promotes acute visceral pain induced by uterine cervical dilation by promoting NR2B phosphorylation.
Xia G, Qian J, Wang Y, Xiao F
Cellular signalling 2025 Mar;127:111610
Cellular signalling 2025 Mar;127:111610
Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence.
Luo T, Chen Z, Zhang F, Liu H, Huang F, Zhang X, Feng J, Ding S, Liu L, Guan W, Zeng A, Hao H
Viruses 2025 Jun 9;17(6)
Viruses 2025 Jun 9;17(6)
Mitigation of Ferroptosis in Diabetic Kidney Disease Through Mesenchymal Stem Cell Intervention via the Smad2/3/METTL3/S1PR1 Axis.
Huang LL, Hou YY, Yang J, Liao XN, Ma JS, Wang WC, Quan YX, Jiang HY, Bai YH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70714
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70714
m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p.
Zhu C, Li R, You X, Xu J, Wang J, Dong D, Chen X, Wang K
NPJ precision oncology 2025 Jun 17;9(1):193
NPJ precision oncology 2025 Jun 17;9(1):193
FTO-mediated m(6)A demethylation regulates IGFBP3 expression and AKT activation through IMP3-dependent P-body re-localisation in lung cancer.
Wang H, Peng H, Zhang Z, Abulimiti Y, Hu J, Zhou Y, Ji P, Li D
Clinical and translational medicine 2025 Jul;15(7):e70392
Clinical and translational medicine 2025 Jul;15(7):e70392
METTL14-mediated m6A modification of ETV4 inhibits tumor development in colorectal cancer.
Liao X, Hu T
Mutation research 2025 Jul-Dec;831:111910
Mutation research 2025 Jul-Dec;831:111910
The m(6)A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia.
Wu X, Liu H, Wang J, Zhang S, Hu Q, Wang T, Cui W, Shi Y, Bai H, Zhou J, Han L, Li L, Zhao T, Wu Y, Luo J, Feng D, Guo W, Ge S, Qu Y
Cell death and differentiation 2025 Jan;32(1):100-117
Cell death and differentiation 2025 Jan;32(1):100-117
Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer.
Liu C, Fan D, Sun J, Li G, Du R, Zuo X, Zhang K, Zhang W, Wang S, Li X, Du M, Wang D, Hao Q, Zhang Y, Li M, Zhang C, Gao Y
Journal of nanobiotechnology 2025 Jan 3;23(1):3
Journal of nanobiotechnology 2025 Jan 3;23(1):3
IDO1 inhibits ferroptosis by regulating FTO-mediated m6A methylation and SLC7A11 mRNA stability during glioblastoma progression.
Tian Q, Dan G, Wang X, Zhu J, Chen C, Tang D, Wang Z, Chen D, Lei S, Yang C, Wang H, Guo B, Jin B, Chen T, Tang L
Cell death discovery 2025 Jan 25;11(1):22
Cell death discovery 2025 Jan 25;11(1):22
The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.
Lan T, Gao F, Cai Y, Lv Y, Zhu J, Liu H, Xie S, Wan H, He H, Xie K, Liu C, Wu H
Nature communications 2025 Jan 2;16(1):333
Nature communications 2025 Jan 2;16(1):333
ALKBH5 alleviates lower extremity arteriosclerosis by regulating ITGB1 demethylation and influencing macrophage polarization.
Guan Z, Wang X, Xu C, Lu R
Heliyon 2025 Jan 15;11(1):e41495
Heliyon 2025 Jan 15;11(1):e41495
N 6-Methyladenosine Demethylase FTO Controls Macrophage Homeostasis in Diabetic Vasculopathy.
Feng S, Zhang Q, Liu Q, Huang C, Zhang H, Wang F, Zhu Y, Jian Q, Chen X, Jiang Q, Yan B
Diabetes 2025 Jan 1;74(1):82-95
Diabetes 2025 Jan 1;74(1):82-95
Organophosphate flame retardant triphenyl phosphate (TPhP) induced colonic fibrosis by bringing about epithelial-mesenchymal transition.
Peng C, Wang M, Zheng C, Zhang X, Chen Y, Wang L
Ecotoxicology and environmental safety 2025 Feb;291:117913
Ecotoxicology and environmental safety 2025 Feb;291:117913
AQP3 Influences Unexplained Recurrent Abortion by Regulating Trophoblast Cell Migration and Invasion via the METTL14/IGF2BP1/AQP3/PI3K/AKT Pathway.
Nong Y, Zhai Q, Liu W, Wei J, Wang Z, Lv X, Li Z, Zhang X, Liu F
Journal of cellular and molecular medicine 2025 Feb;29(3):e70325
Journal of cellular and molecular medicine 2025 Feb;29(3):e70325
METTL14-mediated m6A modification of ZFP14 inhibits clear cell renal cell carcinoma progression via promoting STAT3 ubiquitination.
Liu Z, Sun T, Zhang Z, Piao C, Kong C, Zhang X
Clinical and translational medicine 2025 Feb;15(2):e70232
Clinical and translational medicine 2025 Feb;15(2):e70232
SREBP1c-Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells.
Xin W, Zhou J, Peng Y, Gong S, Liao W, Wang Y, Huang X, Mao Y, Yao M, Qin S, Xiong J, Li Y, Lan Q, Huang Y, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2412233
METTL14 promotes ferroptosis during the development of cisplatin-induced kidney injury by stabilizing ERFE through IGF2BP3-dependent m(6)A methylation.
Chen Y, Li W, Zhao D, Huang C, Xu C
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Dec;92:127793
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2025 Dec;92:127793
METTL3 alleviates renal tubular mitochondrial dysfunction by regulating the TUG1/PGC-1a axis in an IGF2BP2-dependent manner in diabetic nephropathy.
Chen T, Wang J, Xu Y, Zhu Y, Jin Y, Fan Q
Renal failure 2025 Dec;47(1):2521455
Renal failure 2025 Dec;47(1):2521455
Influenza NS1 drives N(6)-methyladenosine (m(6)A)-mediated autoregulation of viral mRNA splicing.
Liao Y, Liu J, Wang P, Mok BW, Chen H
Emerging microbes & infections 2025 Dec;14(1):2572761
Emerging microbes & infections 2025 Dec;14(1):2572761
SARS-CoV-2 and HCoV-OC43 regulate host m6A modification via activation of the mTORC1 signalling pathway to facilitate viral replication.
Zhou S, Hui X, Wang W, Zhao C, Jin M, Qin Y, Chen M
Emerging microbes & infections 2025 Dec;14(1):2447620
Emerging microbes & infections 2025 Dec;14(1):2447620
TRMU Confers Resistance of Melanoma Cells to Vemurafenib through Modulating Mitochondrial Activities.
Guo S, Qi T, Wang Y
Journal of proteome research 2025 Dec 5;24(12):5913-5920
Journal of proteome research 2025 Dec 5;24(12):5913-5920
The METTL3-YTHDC1 axis mediates architectural RNA m(6)A modification to modulate the integrity of chromatin TADs in MLLr + AML genome.
Fu R, Yu W, Zhao R, Yang H, Cao B, Dai C, Qianjiang H, Xia Y, Wang L, Lu J, Zhou R, Shi A, Lou H, Zhang X, Luo H
Molecular cancer 2025 Dec 22;25(1):22
Molecular cancer 2025 Dec 22;25(1):22
Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m(6)A RNA methylation.
Liang C, Fu R, Chen D, Tian G, He J, Zheng P, Yu J, Pu J, Yu B
Journal of animal science and biotechnology 2025 Dec 2;16(1):163
Journal of animal science and biotechnology 2025 Dec 2;16(1):163
USP25 deubiquitinates cytosolic METTL3 to impede glioma proliferation via an m6A-independent pathway.
Zhang B, Han W, Gao X, Li W, Yu J, Zhao W, He J, Qiu X, Lu Z, Zhou L, Hu Y, Xie Y, Geng Y, Lu H, Zhao W, Liao X, Chen S, Liu X, Chen S, Tan G, Zhang Y, Wang Z
iScience 2025 Dec 19;28(12):113918
iScience 2025 Dec 19;28(12):113918
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Liu X, Cui Y, Gong J, Yu X, Cui Y, Xuan Y
Oncogene 2025 Aug;44(29):2474-2489
Oncogene 2025 Aug;44(29):2474-2489
SETD2 drives METTL14-mediated m(6)A to suppress Piezo1 Attenuation and activate TGM2 to promote pulmonary hypertension.
Zhao SS, Yuan C, Liu JL, Wu QC, Zhou XL
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):302
Cellular and molecular life sciences : CMLS 2025 Aug 8;82(1):302
Treponema pallidum lipoprotein TpF1 regulates METTL14-mediated NF-κB signaling pathway to promote macrophage M2 polarization.
Cao Q, Zhou X, Zou F, He R, He L, Chen J, Li Y, Cao T, Li Y, Lan X, Liu S
Journal of leukocyte biology 2025 Aug 5;117(8)
Journal of leukocyte biology 2025 Aug 5;117(8)
Phospholipase Cε1 activates Rap1 signaling pathway to promote proliferation, EMT and angiogenesis of choriocarcinoma cells.
Wang D, Liu C, Tian C, Fang J, Ye K
Molecular biology reports 2025 Aug 4;52(1):790
Molecular biology reports 2025 Aug 4;52(1):790
HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.
He X, Li Y, Li J, Li Y, Chen S, Yan X, Xie Z, Du J, Chen G, Song J, Mei Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413121
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2413121
N6-Methyladenosine-Modified circSMAD4 Prevents Lumbar Instability Induced Cartilage Endplate Ossification.
Li H, Tang Y, Hu S, Ruan X, Zhang J, Shi Y, Qiu L, Yang H, Zhang K, Chen H, Chen K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413970
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2413970
PRMT5-mediated methylation of METTL3 promotes cisplatin resistance in ovarian cancer by facilitating DNA repair mechanisms.
Xia Q, Zhong R, Zheng J, Zhou X, Zhao X, Wang S, Wang B, Wu Q, Xie C, Kong B, Zhang Q, Huang T
Cell reports 2025 Apr 22;44(4):115484
Cell reports 2025 Apr 22;44(4):115484
RNA Methylation and Transcriptome Analysis Reveal Key Regulatory Pathways Related to Cadmium-Induced Liver Damage.
Huang H, Li G, Guo S, Li K, Li W, Zhou Q, He Z, Yang X, Liu L, Wei Q
Chemical research in toxicology 2025 Apr 21;38(4):717-732
Chemical research in toxicology 2025 Apr 21;38(4):717-732
Thiamine and METTL14 in Diabetes Management with Intensive Insulin Therapy.
Peng M, Zhang Y, Weng X, Wu J, Luo T, Dong Y, Wen S, Liang N, Zhong L, Zhai Y, Xie Y, Xie Y, Chen Y
Biomedicines 2025 Apr 17;13(4)
Biomedicines 2025 Apr 17;13(4)
N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.
Jiang S, Gao L, Li J, Zhang F, Zhang Y, Liu J
Frontiers in cell and developmental biology 2024;12:1383232
Frontiers in cell and developmental biology 2024;12:1383232
Dexmedetomidine improves mitophagy and pyroptosis through the ALKBH5/FUNDC1 axis during epidural-related maternal fever.
Xiao F, Yao H, Qian J, Huang J, Xia G
Advances in medical sciences 2024 Sep;69(2):272-280
Advances in medical sciences 2024 Sep;69(2):272-280
H3K36 methyltransferase SMYD2 affects cell proliferation and migration in Hirschsprung's disease by regulating METTL3.
Hou X, Yang Y, Wang C, Huang Z, Zhang M, Yang J, Li N, Yang H, Yang L, Wu K
Journal of cellular physiology 2024 Sep;239(9):e31402
Journal of cellular physiology 2024 Sep;239(9):e31402
METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.
Wang P, Zhou W, Chen F, Zhang X, Zhang Q, Chen Y, Zhang N
Experimental gerontology 2024 Sep;194:112496
Experimental gerontology 2024 Sep;194:112496
Epitranscriptomic reader YTHDF2 regulates SEK1(MAP2K4)-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress.
Malovic E, Ealy A, Miller C, Jang A, Hsu PJ, Sarkar S, Rokad D, Goeser C, Hartman AK, Zhu A, Palanisamy B, Zenitsky G, Jin H, Anantharam V, Kanthasamy A, He C, Kanthasamy AG
iScience 2024 Sep 20;27(9):110619
iScience 2024 Sep 20;27(9):110619
METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma.
Wang J, Xiu M, Wang J, Gao Y, Li Y
Journal of hematology & oncology 2024 Sep 2;17(1):78
Journal of hematology & oncology 2024 Sep 2;17(1):78
N6-Methyladenosine Positively Regulates Coxsackievirus B3 Replication.
Zhao H, Gao Z, Sun J, Qiao H, Zhao Y, Cui Y, Zhao B, Wang W, Chiu S, Chuai X
Viruses 2024 Sep 11;16(9)
Viruses 2024 Sep 11;16(9)
Zinc finger protein 180 induces an apoptotic phenotype by activating METTL14 transcriptional activity in colorectal cancer.
Xu L, Chen XJ, Yan Q, Lei XT, Liu HL, Xu JP, Shang WT, Huang JL, Chen ZT, Tan XL, Lin HJ, Fu XH, Zheng LS, Lan P, Huang Y
Oncology reports 2024 Oct;52(4)
Oncology reports 2024 Oct;52(4)
METTL14-mediated N6-methyladenosine modification of TCP1 mRNA promotes acute myeloid leukemia progression.
Zhang M, Xie Z, Tan Y, Wu Y, Wang M, Zhang P, Yuan Y, Li J
Cellular signalling 2024 Oct;122:111304
Cellular signalling 2024 Oct;122:111304
Intracellular C5aR1 inhibits ferroptosis in glioblastoma through METTL3-dependent m6A methylation of GPX4.
Meng X, Wang Z, Yang Q, Liu Y, Gao Y, Chen H, Li A, Li R, Wang J, Sun G
Cell death & disease 2024 Oct 5;15(10):729
Cell death & disease 2024 Oct 5;15(10):729
Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11.
Zhou B, Luo Y, Bi H, Zhang N, Ma M, Dong Z, Ji N, Zhang S, Wang X, Liu Y, Guo X, Wei W, Xie C, Wu L, Wan X, Zheng MH, Zhao B, Li Y, Hu C, Lu Y
Cell metabolism 2024 Oct 1;36(10):2228-2244.e7
Cell metabolism 2024 Oct 1;36(10):2228-2244.e7
TGF-β Promotes Hepatocellular Carcinoma Metastasis Through Through m6A Modification of PCDHGA9.
Wang H, Guan W, Zhang X, Wu Y, Ou Y, Zhang Y, Zeng Z, Yao H
Cancer biotherapy & radiopharmaceuticals 2024 Nov;39(9):644-653
Cancer biotherapy & radiopharmaceuticals 2024 Nov;39(9):644-653
Downregulated KLF4, induced by m6A modification, aggravates intestinal barrier dysfunction in inflammatory bowel disease.
Zhu X, Wang J, Zhang H, Yue H, Zhu J, Li J, Wang K, Shen K, Yang K, Leng X, Xi Q, Shi T
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Cellular and molecular life sciences : CMLS 2024 Nov 29;81(1):470
Epitranscriptomic m(6)A modifications during reactivation of HIV-1 latency in CD4(+) T cells.
Mishra T, Phillips S, Zhao Y, Wilms B, He C, Wu L
mBio 2024 Nov 13;15(11):e0221424
mBio 2024 Nov 13;15(11):e0221424
METTL14-mediated m6A methylation regulates pathological retinal neovascularization by targeting autophagy.
Yu Y, Nie H, Qin X, Chen X, Li X, Yao J
Experimental cell research 2024 Nov 1;443(1):114291
Experimental cell research 2024 Nov 1;443(1):114291
METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m(6)A-dependent manner.
Chen L, Hu Y, Zhang M, Liu L, Ma J, Xu Z, Zhang J, Gu H, Chen K
Aging cell 2024 May;23(5):e14123
Aging cell 2024 May;23(5):e14123
Manganese induces podocyte injury through regulating MTDH/ALKBH5/NLRP10 axis: Combined analysis at epidemiology and molecular biology levels.
Liang Q, Jing J, He H, Huang X, Liu J, Wang M, Qi Z, Zhang L, Huang Z, Yan Y, Liu S, Gao M, Zou Y
Environment international 2024 May;187:108672
Environment international 2024 May;187:108672
IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis.
Nan Y, Chen M, Wu W, Huang R, Sun W, Lu Q, Gu Z, Mao X, Xu H, Wang Y
Cell death discovery 2024 May 3;10(1):215
Cell death discovery 2024 May 3;10(1):215
Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis.
Ji W, Huo Y, Zhang Y, Qian X, Ren Y, Hu C, Zhang J
International immunopharmacology 2024 May 10;132:111968
International immunopharmacology 2024 May 10;132:111968
Classical swine fever virus non-structural protein 5B hijacks host METTL14-mediated m6A modification to counteract host antiviral immune response.
Chen J, Song HX, Hu JH, Bai JS, Li XH, Sun RC, Zhao BQ, Li MZ, Zhou B
PLoS pathogens 2024 Mar;20(3):e1012130
PLoS pathogens 2024 Mar;20(3):e1012130
HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to promote neuroblastoma progression.
Hu T, Zeng C, Song Z, Liu Q, Chen S, Huang W, Ma Q, Li H
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167050
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167050
IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.
Yuan D, Li H, Dai W, Zhou X, Zhou W, He L
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022
METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.
Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, Zhan HW, Sheng XY, Xu LH, Ren XJ, Yang F, Geng B, Xia YY
Cellular signalling 2024 Mar;115:111038
Cellular signalling 2024 Mar;115:111038
Landscape of transcriptome-wide m(6)A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise.
Chen C, Jiang C, Lin T, Hu Y, Wu H, Xiang Q, Yang M, Wang S, Han X, Tao J
Acta physiologica (Oxford, England) 2024 Jun;240(6):e14154
Acta physiologica (Oxford, England) 2024 Jun;240(6):e14154
CircUGGT2 downregulation by METTL14-dependent m(6)A modification suppresses gastric cancer progression and cisplatin resistance through interaction with miR-186-3p/MAP3K9 axis.
Chen XY, Yang YL, Yu Y, Chen ZY, Fan HN, Zhang J, Zhu JS
Pharmacological research 2024 Jun;204:107206
Pharmacological research 2024 Jun;204:107206
Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
Hu W, Wang M, Sun G, Zhang L, Lu H
Cellular signalling 2024 Jun;118:111139
Cellular signalling 2024 Jun;118:111139
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
LncRNA CARMN m6A demethylation by ALKBH5 inhibits mutant p53-driven tumour progression through miR-5683/FGF2.
Liu N, Jiang X, Zhang G, Long S, Li J, Jiang M, Jia G, Sun R, Zhang L, Zhang Y
Clinical and translational medicine 2024 Jul;14(7):e1777
Clinical and translational medicine 2024 Jul;14(7):e1777
m6A-Mediated IRS1 Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling.
Xiao Y, Zhu X, Li Q, Wang Z, Zuo Q, Liu X, Tan J
Frontiers in bioscience (Landmark edition) 2024 Jul 19;29(7):257
Frontiers in bioscience (Landmark edition) 2024 Jul 19;29(7):257
Characterization of m6A Modifiers and RNA Modifications in Uterine Fibroids.
George JW, Cancino RA, Griffin Miller JL, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
Endocrinology 2024 Jul 1;165(8)
Endocrinology 2024 Jul 1;165(8)
METTL3 and METTL14 regulate IL-6 expression via RNA m6A modification of zinc transporter SLC39A9 and DNA methylation of IL-6 in periodontal ligament cells.
Huang J, Wang Y, Zhou Y
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119605
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119605
Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.
Fang X, Ao X, Xiao D, Wang Y, Jia Y, Wang P, Li M, Wang J
Cellular & molecular biology letters 2024 Jan 3;29(1):3
Cellular & molecular biology letters 2024 Jan 3;29(1):3
Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.
Dai W, Tian R, Yu L, Bian S, Chen Y, Yin B, Luan Y, Chen S, Fan Z, Yan R, Pan X, Hou Y, Li R, Chen J, Shu M
Nature communications 2024 Jan 2;15(1):131
Nature communications 2024 Jan 2;15(1):131
FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.
Chen K, Wang Y, Dai X, Luo J, Hu S, Zhou Z, Shi J, Pan X, Cao T, Xia J, Li Y, Wang Z, Ma J
Cell death & disease 2024 Jan 12;15(1):37
Cell death & disease 2024 Jan 12;15(1):37
METTL14 enhances the m6A modification level of lncRNA MSTRG.292666.16 to promote the progression of non-small cell lung cancer.
Ji X, Wan X, Sun H, Deng Q, Meng S, Xie B, Zhou S
Cancer cell international 2024 Feb 7;24(1):61
Cancer cell international 2024 Feb 7;24(1):61
The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability.
Zhang J, Chen F, Tang M, Xu W, Tian Y, Liu Z, Shu Y, Yang H, Zhu Q, Lu X, Peng B, Liu X, Xu X, Gullerova M, Zhu WG
Cell reports 2024 Feb 27;43(2):113779
Cell reports 2024 Feb 27;43(2):113779
The m(6)A modification of ACSL4 mRNA sensitized esophageal squamous cell carcinoma to irradiation via accelerating ferroptosis.
Jin Y, Pan S, Wang M, Huang S, Ke Y, Li D, Luo H, Kou Z, Shi D, Kou W, Fu H, Pan J
Cell biology international 2024 Dec;48(12):1877-1890
Cell biology international 2024 Dec;48(12):1877-1890
HNRNPH1 stabilizes FLOT2 mRNA in a non-canonical m6A-dependent manner to promote malignant progression in nasopharyngeal carcinoma.
Li Q, Liu J, Zeng C, Qin D, Zhang Z, Lv Q, Li J, Huang W
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2279-2295
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2279-2295
METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Yang J, Jiang T, Lu X, Li X, Zhou X, Guo X, Ma C, Xie X, Li D, Yu S, An J, Zhao B, Li H
International immunopharmacology 2024 Dec 25;143(Pt 1):113308
International immunopharmacology 2024 Dec 25;143(Pt 1):113308
WTAP and METTL14 regulate the m6A modification of DKK3 in renal tubular epithelial cells of diabetic nephropathy.
Fu K, Jing C, Shi J, Mao S, Lu R, Yang M, Chen Y, Qian B, Wang Y, Li L
Biochemical and biophysical research communications 2024 Dec 17;738:150524
Biochemical and biophysical research communications 2024 Dec 17;738:150524
Chronic social isolation leads to abnormal behavior in male mice through the hippocampal METTL14 mediated epitranscriptomic RNA m6A modifications.
Xu XF, Chen J, Long LH, Zhang AM, Yang JW, Li YJ, Chen L, Zhong XL, Xu Y, Cao WY
Journal of affective disorders 2024 Dec 1;366:262-272
Journal of affective disorders 2024 Dec 1;366:262-272
piR-27222 mediates PM(2.5)-induced lung cancer by resisting cell PANoptosis through the WTAP/m(6)A axis.
Ma W, Xu L, Wang Y, Chen S, Li D, Huo X, Li R, Zhu X, Chen N, Jin Y, Luo J, Li C, Zhao K, Zheng Y, Han W, Yu D
Environment international 2024 Aug;190:108928
Environment international 2024 Aug;190:108928
Endogenous RBM4 prevents Ang II-induced cardiomyocyte hypertrophy via downregulating the expression of PTBP1.
Sun W, Fang X, Zhang H, Lu Y, Wang P, Li J, Li M
Acta biochimica et biophysica Sinica 2024 Aug 7;57(3):365-377
Acta biochimica et biophysica Sinica 2024 Aug 7;57(3):365-377
Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9-mediated inhibition of N6-methyladenosine demethylase FTO.
Gong X, Liang Y, Wang J, Pang Y, Wang F, Chen X, Zhang Q, Song C, Wang Y, Zhang C, Fang X, Chen X
The Journal of biological chemistry 2024 Apr;300(4):107199
The Journal of biological chemistry 2024 Apr;300(4):107199
RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.
Sun Y, Chen D, Sun S, Ren M, Zhou L, Chen C, Zhao J, Wei H, Zhao Q, Qi Y, Zhang J, Zhang G, Liu H, Yang Q, Liu Q, Wang Y, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122
A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.
Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, Li T, Zhao X, Lei L, Zhao Q, Liu D, Wang B, Wu X
Cell reports 2024 Apr 23;43(4):114032
Cell reports 2024 Apr 23;43(4):114032
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
Wang J, Yin H, Li G, Wu D, Xu Y, Chen Y, Wang X, Xing Y, Zhang T, Fei D, Yang P, Fang F, Tao Y, Li X, Yu J, Yang Y, Li Z, Shi L, Zhang Z, Pan J
Cell death discovery 2024 Apr 22;10(1):186
Cell death discovery 2024 Apr 22;10(1):186
Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.
Qiao Y, Su M, Zhao H, Liu H, Wang C, Dai X, Liu L, Liu G, Sun H, Sun M, Wang J, Li Z, Fan J, Zhang Q, Li C, Situ F, Xue J, Jia Z, Zhang C, Zhang S, Shan C
Journal of experimental & clinical cancer research : CR 2024 Apr 10;43(1):108
Journal of experimental & clinical cancer research : CR 2024 Apr 10;43(1):108
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
Guan S, Chen X, Wei Y, Wang F, Xie W, Chen Y, Liang H, Zhu X, Yang Y, Fang W, Huang Y, Zhao H, Zhang X, Liu S, Zhuang W, Huang M, Wang X, Zhang L
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
METTL14 Regulates PLAGL2/β-Catenin Signaling Axis to Promote the Development of Nonsmall Cell Lung Cancer.
Zhou Q, Lai X, Gao Y, Chen Q, Xu Y, Liu Y
Journal of oncology 2023;2023:4738586
Journal of oncology 2023;2023:4738586
Suppression of Wnt/β-catenin Signaling in PDAC via METTL16-mediated N6-methyladenosine Modification of DVL2.
Yu L, Lu J, Xie N, Fang L, Chen S, Wu Y, Wang X, Li B
Journal of Cancer 2023;14(16):2964-2977
Journal of Cancer 2023;14(16):2964-2977
IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer.
Guan XQ, Yuan XN, Feng KX, Shao YC, Liu Q, Yang ZL, Chen YY, Deng J, Hu MS, Li J, Tian YH, Chu MF, Zhang JW, Wei L
American journal of cancer research 2023;13(7):2948-2968
American journal of cancer research 2023;13(7):2948-2968
Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.
Li X, Fang J, Tao X, Xia J, Cheng B, Wang Y
PeerJ 2023;11:e14824
PeerJ 2023;11:e14824
ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.
An X, Wu W, Yang L, Dong J, Liu B, Guo J, Chen J, Guo B, Cao W, Jiang Q
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71
HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.
Huo FC, Zhu ZM, Du WQ, Pan YJ, Jiang X, Kang MJ, Liu BW, Mou J, Pei DS
Pharmacological research 2023 Sep;195:106863
Pharmacological research 2023 Sep;195:106863
AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.
Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181
Cell biology and toxicology 2023 Oct;39(5):2165-2181
Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane.
Wu Y, Yang Z, Su S, Xu X, Li Y, Li X, Gao Y, Sun D, Wan S, Pen M, Jin W, Ke C
Cell biology and toxicology 2023 Oct;39(5):2133-2148
Cell biology and toxicology 2023 Oct;39(5):2133-2148
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
Mettl3 induced miR-338-3p expression in dendritic cells promotes antigen-specific Th17 cell response via regulation of Dusp16.
Wei Y, Yang C, Liu Y, Sun D, Li X, Wei R, Nian H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23277
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23277
Macrophage membrane-coated nanovesicles for dual-targeted drug delivery to inhibit tumor and induce macrophage polarization.
Huang X, Wang L, Guo H, Zhang W
Bioactive materials 2023 May;23:69-79
Bioactive materials 2023 May;23:69-79
Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.
Zheng J, Zhang Q, Zhao Z, Qiu Y, Zhou Y, Wu Z, Jiang C, Wang X, Jiang X
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127
Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells.
Huang J, Guo C, Wang Y, Zhou Y
Tissue & cell 2023 Jun;82:102081
Tissue & cell 2023 Jun;82:102081
Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating NEAT1 Through N6-Methyladenosine Modifications.
Yang Q, Chen S, Wang X, Yang X, Chen L, Huang T, Zheng Y, Zheng X, Wu X, Sun Y, Wu J
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):910-926
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):910-926
Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.
Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747
Veterinary microbiology 2023 Jun;281:109747
FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.
Li B, Xi W, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J, Han B, Yao H
Nature communications 2023 Jan 30;14(1):489
Nature communications 2023 Jan 30;14(1):489
The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.
Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116
NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.
Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246
ALKBH1-mediated m(1) A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.
Chen W, Wang H, Mi S, Shao L, Xu Z, Xue M
Molecular oncology 2023 Feb;17(2):344-364
Molecular oncology 2023 Feb;17(2):344-364
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Chen Y, Liu X, Li L, He X, Zheng F, Zhang Y, Gao H, Jin Z, Wu D, Wang Q, Tao H, Zhao Y, Liu W, Zou L
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19
Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.
Zhou H, Yan Y, Gao J, Ma M, Liu Y, Shi X, Zhang Q, Xu X
Journal of virology 2023 Feb 28;97(2):e0175122
Journal of virology 2023 Feb 28;97(2):e0175122
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Sun K, Chen L, Li Y, Huang B, Yan Q, Wu C, Lai Q, Fang Y, Cai J, Liu Y, Chen J, Wang X, Zhu Y, Dong S, Tan J, Li A, Liu S, Zhang Y
Cell death & disease 2023 Feb 21;14(2):148
Cell death & disease 2023 Feb 21;14(2):148
m (6) A RNA methylation orchestrates transcriptional dormancy during developmental pausing.
Collignon E, Cho B, Fothergill-Robinson J, Furlan G, Ross RL, Limbach PA, Ramalho-Santos M
bioRxiv : the preprint server for biology 2023 Feb 1;
bioRxiv : the preprint server for biology 2023 Feb 1;
Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.
Gao X, Liang X, Liu B, Hong Y, He H, Shen Y, Chen J, Huang X, Hu B, Li W, Li X, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294
METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis.
Chen Y, Wu Y, Fang L, Zhao H, Xu S, Shuai Z, Yu H, Cai G, Zhan HQ, Pan F
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109838
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109838
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
Molecular cell 2023 Dec 7;83(23):4334-4351.e7
m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.
Zhang J, Song J, Liu S, Zhang Y, Qiu T, Jiang L, Bai J, Yao X, Wang N, Yang G, Sun X
The Science of the total environment 2023 Dec 20;905:167202
The Science of the total environment 2023 Dec 20;905:167202
Coilin mediates m6A RNA methylation through phosphorylation of METTL3.
McLaurin DM, Tucker SK, Hebert MD
Biology open 2023 Dec 15;12(12)
Biology open 2023 Dec 15;12(12)
Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma.
Cun Y, An S, Zheng H, Lan J, Chen W, Luo W, Yao C, Li X, Huang X, Sun X, Wu Z, Hu Y, Li Z, Zhang S, Wu G, Yang M, Tang M, Yu R, Liao X, Gao G, Zhao W, Wang J, Li J
Genomics, proteomics & bioinformatics 2023 Aug;21(4):707-728
Genomics, proteomics & bioinformatics 2023 Aug;21(4):707-728
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.
Gu Z, Liu J, Qin L, Zhang Y, Cui W, Huang H, Liu L, Cao Y, Zhang H
Journal of dermatological science 2023 Aug;111(2):43-51
Journal of dermatological science 2023 Aug;111(2):43-51
Characterization of m(6)A modifiers and RNA modifications in uterine fibroids.
George JW, Cancino RA, Miller JLG, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
bioRxiv : the preprint server for biology 2023 Aug 9;
bioRxiv : the preprint server for biology 2023 Aug 9;
Smoking and tetramer tryptase accelerate intervertebral disc degeneration by inducing METTL14-mediated DIXDC1 m(6) modification.
Tu J, Li W, Hansbro PM, Yan Q, Bai X, Donovan C, Kim RY, Galvao I, Das A, Yang C, Zou J, Diwan A
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Aug 2;31(8):2524-2542
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Aug 2;31(8):2524-2542
A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.
Yan C, Xiong J, Zhou Z, Li Q, Gao C, Zhang M, Yu L, Li J, Hu MM, Zhang CS, Cai C, Zhang H, Zhang J
eLife 2023 Aug 17;12
eLife 2023 Aug 17;12
METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury.
Li W, Tan M, Wang H, Wang Z, Pang Y, Yang R, Zhong S, Pan X, Chen S, Wang Q, Li D, Xiao Y, Chen W, Chen L
Environmental pollution (Barking, Essex : 1987) 2023 Aug 15;331(Pt 2):121887
Environmental pollution (Barking, Essex : 1987) 2023 Aug 15;331(Pt 2):121887
METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.
Hou X, Li Y, Song J, Peng L, Zhang W, Liu R, Yuan H, Feng T, Li J, Li W, Zhu C
Hepatology communications 2023 Aug 1;7(8)
Hepatology communications 2023 Aug 1;7(8)
Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m(6)A-modified long non-coding RNAs in lung adenocarcinoma.
Ping Y, Huang J, Zhu J, Sun Z, Shang A, Chen C, Liu W, Li D
Clinical epigenetics 2023 Apr 7;15(1):60
Clinical epigenetics 2023 Apr 7;15(1):60
METTL14 Regulates Intestine Cellular Senescence through m(6)A Modification of Lamin B Receptor.
Zhang Z, Xue M, Chen J, Wang Z, Ju F, Ni J, Sun J, Wu H, Zheng H, Lou Z, Zhang Y, Yang X, Chen S, Xi Y, Wang L
Oxidative medicine and cellular longevity 2022;2022:9096436
Oxidative medicine and cellular longevity 2022;2022:9096436
YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.
Li Z, Teng M, Jiang Y, Zhang L, Luo X, Liao Y, Yang B
Frontiers in immunology 2022;13:857727
Frontiers in immunology 2022;13:857727
METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.
Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350
Nature communications 2022 Oct 26;13(1):6350
Adenosine N(6)-methylation upregulates the expression of human CYP2B6 by altering the chromatin status.
Isono M, Nakano M, Fukami T, Nakajima M
Biochemical pharmacology 2022 Nov;205:115247
Biochemical pharmacology 2022 Nov;205:115247
Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.
Yang Y, Qian Cai Q, Sheng Fu L, Wei Dong Y, Fan F, Zhong Wu X
Chemistry & biodiversity 2022 Nov;19(11):e202200333
Chemistry & biodiversity 2022 Nov;19(11):e202200333
N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.
Shi HZ, Xiong JS, Gan L, Zhang Y, Zhang CC, Kong YQ, Miao QJ, Tian CC, Li R, Liu JQ, Zhang EJ, Bu WB, Wang Y, Cheng XF, Sun JF, Chen H
Clinical and translational medicine 2022 Nov;12(11):e1075
Clinical and translational medicine 2022 Nov;12(11):e1075
Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.
Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131
Discover oncology 2022 Nov 25;13(1):131
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615
Cancer letters 2022 May 28;534:215615
Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant m6A RNA modification in head and neck squamous cell carcinoma.
Chen X, Liu Y, Sun D, Sun R, Wang X, Li M, Song N, Ying J, Guo T, Jiang Y
Cancer science 2022 Jun;113(6):2071-2084
Cancer science 2022 Jun;113(6):2071-2084
DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.
Zhao L, Zhao Y, Liu Q, Huang J, Lu Y, Ping J
Microbiology spectrum 2022 Jun 29;10(3):e0109822
Microbiology spectrum 2022 Jun 29;10(3):e0109822
PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.
Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
Developmental cell 2022 Jun 20;57(12):1466-1481.e6
The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers.
Zhang Y, Ma Z, Li C, Wang C, Jiang W, Chang J, Han S, Lu Z, Shao Z, Wang Y, Wang H, Jiao C, Wang D, Wu X, Shen H, Wang X, Hu Z, Li X
Nature communications 2022 Jun 1;13(1):3061
Nature communications 2022 Jun 1;13(1):3061
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
Liu Z, Cai Y, Deng M, Li D, Leng Q, Shi L, Tang Y, Wang F, Wan Y
Cell and tissue research 2022 Jan;387(1):131-142
Cell and tissue research 2022 Jan;387(1):131-142
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.
Gao M, Qi Z, Feng W, Huang H, Xu Z, Dong Z, Xu M, Han J, Kloeber JA, Huang J, Lou Z, Liu S
The Journal of biological chemistry 2022 Feb;298(2):101563
The Journal of biological chemistry 2022 Feb;298(2):101563
The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.
Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766
Brain research 2022 Feb 15;1777:147766
Mechanism of METTL14-mediated m(6)A modification in non-small cell lung cancer cell resistance to cisplatin.
Gong S, Wang S, Shao M
Journal of molecular medicine (Berlin, Germany) 2022 Dec;100(12):1771-1785
Journal of molecular medicine (Berlin, Germany) 2022 Dec;100(12):1771-1785
The landscape of m6A regulators in esophageal cancer: molecular characteristics, immuno-oncology features, and clinical relevance.
Li Z, Zheng C, Huang L, Yin X, Wang Z, Liu C, Li B
Annals of translational medicine 2022 Dec;10(24):1347
Annals of translational medicine 2022 Dec;10(24):1347
PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y
The EMBO journal 2022 Aug 16;41(16):e110439
The EMBO journal 2022 Aug 16;41(16):e110439
Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing's sarcoma.
Jiang J, Fan Q, Qu H, Liu C, Liang T, Chen L, Huang S, Sun X, Chen J, Chen T, Li H, Yao Y, Zhan X
Scientific reports 2022 Apr 29;12(1):7041
Scientific reports 2022 Apr 29;12(1):7041
Mettl14-Mediated m6A Modification Is Essential for Germinal Center B Cell Response.
Huang H, Zhang G, Ruan GX, Li Y, Chen W, Zou J, Zhang R, Wang J, Ji SJ, Xu S, Ou X
Journal of immunology (Baltimore, Md. : 1950) 2022 Apr 15;208(8):1924-1936
Journal of immunology (Baltimore, Md. : 1950) 2022 Apr 15;208(8):1924-1936
Methylation and Expression of the Exercise-Related TLR1 Gene Is Associated With Low Grade Glioma Prognosis and Outcome.
Lu L, Hu Y, Wang C, Jiang F, Wu C
Frontiers in molecular biosciences 2021;8:747933
Frontiers in molecular biosciences 2021;8:747933
MMP24 Contributes to Neuropathic Pain in an FTO-Dependent Manner in the Spinal Cord Neurons.
Ma L, Huang Y, Zhang F, Gao DS, Sun N, Ren J, Xia S, Li J, Peng X, Yu L, Jiang BC, Yan M
Frontiers in pharmacology 2021;12:673831
Frontiers in pharmacology 2021;12:673831
Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer.
Lv W, Wang Y, Zhao C, Tan Y, Xiong M, Yi Y, He X, Ren Y, Wu Y, Zhang Q
Frontiers in oncology 2021;11:745719
Frontiers in oncology 2021;11:745719
Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.
Li K, Gao S, Ma L, Sun Y, Peng ZY, Wu J, Du N, Ren H, Tang SC, Sun X
Frontiers in oncology 2021;11:731561
Frontiers in oncology 2021;11:731561
M6A "Writer" Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer.
Cai C, Long J, Huang Q, Han Y, Peng Y, Guo C, Liu S, Chen Y, Shen E, Long K, Wang X, Yu J, Shen H, Zeng S
Frontiers in oncology 2021;11:615296
Frontiers in oncology 2021;11:615296
m(6)A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.
Takemoto S, Nakano M, Fukami T, Nakajima M
Biochemical pharmacology 2021 Nov;193:114766
Biochemical pharmacology 2021 Nov;193:114766
Isorhapontigenin (ISO) inhibits EMT through FOXO3A/METTL14/VIMENTIN pathway in bladder cancer cells.
Zhang N, Hua X, Tu H, Li J, Zhang Z, Max C
Cancer letters 2021 Nov 1;520:400-408
Cancer letters 2021 Nov 1;520:400-408
mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.
Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I
Molecular cell 2021 May 20;81(10):2076-2093.e9
Molecular cell 2021 May 20;81(10):2076-2093.e9
Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.
Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361
Cell research 2021 Mar;31(3):345-361
AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352
Clinical and translational medicine 2021 Mar;11(3):e352
The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.
Ondo K, Isono M, Nakano M, Hashiba S, Fukami T, Nakajima M
Biochemical pharmacology 2021 Jul;189:114402
Biochemical pharmacology 2021 Jul;189:114402
Knockdown of METTL14 suppresses the malignant progression of non-small cell lung cancer by reducing Twist expression.
Yang F, Yuan WQ, Li J, Luo YQ
Oncology letters 2021 Dec;22(6):847
Oncology letters 2021 Dec;22(6):847
YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.
Zhu X, Yang H, Zhang M, Wu X, Jiang L, Liu X, Lv K
Cancer cell international 2021 Dec 4;21(1):645
Cancer cell international 2021 Dec 4;21(1):645
ALKBH5-mediated m(6)A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling.
He Y, Yue H, Cheng Y, Ding Z, Xu Z, Lv C, Wang Z, Wang J, Yin C, Hao H, Chen C
Cell death & disease 2021 Dec 1;12(12):1121
Cell death & disease 2021 Dec 1;12(12):1121
The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.
Ma S, Yan J, Barr T, Zhang J, Chen Z, Wang LS, Sun JC, Chen J, Caligiuri MA, Yu J
The Journal of experimental medicine 2021 Aug 2;218(8)
The Journal of experimental medicine 2021 Aug 2;218(8)
The m(6)A methylome of SARS-CoV-2 in host cells.
Liu J, Xu YP, Li K, Ye Q, Zhou HY, Sun H, Li X, Yu L, Deng YQ, Li RT, Cheng ML, He B, Zhou J, Li XF, Wu A, Yi C, Qin CF
Cell research 2021 Apr;31(4):404-414
Cell research 2021 Apr;31(4):404-414
METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.
Shi Y, Zhuang Y, Zhang J, Chen M, Wu S
Cancer management and research 2020;12:13173-13184
Cancer management and research 2020;12:13173-13184
METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications.
Jian D, Wang Y, Jian L, Tang H, Rao L, Chen K, Jia Z, Zhang W, Liu Y, Chen X, Shen X, Gao C, Wang S, Li M
Theranostics 2020;10(20):8939-8956
Theranostics 2020;10(20):8939-8956
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA.
Gao XQ, Zhang YH, Liu F, Ponnusamy M, Zhao XM, Zhou LY, Zhai M, Liu CY, Li XM, Wang M, Shan C, Shan PP, Wang Y, Dong YH, Qian LL, Yu T, Ju J, Wang T, Wang K, Chen XZ, Wang YH, Zhang J, Li PF, Wang K
Nature cell biology 2020 Nov;22(11):1319-1331
Nature cell biology 2020 Nov;22(11):1319-1331
Analysis of METTL3 and METTL14 in hepatocellular carcinoma.
Liu X, Qin J, Gao T, Li C, Chen X, Zeng K, Xu M, He B, Pan B, Xu X, Pan Y, Sun H, Xu T, Wang S
Aging 2020 Nov 6;12(21):21638-21659
Aging 2020 Nov 6;12(21):21638-21659
ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.
Tian J, Ying P, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, Wang X, Mei S, Zhang Y, Wang C, Zhong R, Chang J, Miao X
International journal of cancer 2020 Jun 15;146(12):3281-3293
International journal of cancer 2020 Jun 15;146(12):3281-3293
Alteration of N(6)-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.
Li X, Fan X, Yin X, Liu H, Yang Y
Epigenomics 2020 Jul;12(14):1157-1173
Epigenomics 2020 Jul;12(14):1157-1173
Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy.
Li G, Song Y, Liao Z, Wang K, Luo R, Lu S, Zhao K, Feng X, Liang H, Ma L, Wang B, Ke W, Yin H, Zhan S, Li S, Wu X, Zhang Y, Yang C
Cell death & disease 2020 Feb 6;11(2):103
Cell death & disease 2020 Feb 6;11(2):103
Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.
Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644
m(6)A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.
Wang Y, Sun J, Lin Z, Zhang W, Wang S, Wang W, Wang Q, Ning G
Diabetes 2020 Aug;69(8):1708-1722
Diabetes 2020 Aug;69(8):1708-1722
AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.
Wu W, Wang S, Liu Q, Shan T, Wang X, Feng J, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4852-4869
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4852-4869
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Geng F, Fan MJ, Li J, Liang SM, Li CY, Li N
Translational cancer research 2019 Oct;8(6):2307-2315
Translational cancer research 2019 Oct;8(6):2307-2315
Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.
Xue M, Zhao BS, Zhang Z, Lu M, Harder O, Chen P, Lu Z, Li A, Ma Y, Xu Y, Liang X, Zhou J, Niewiesk S, Peeples ME, He C, Li J
Nature communications 2019 Oct 9;10(1):4595
Nature communications 2019 Oct 9;10(1):4595
EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.
Lang F, Singh RK, Pei Y, Zhang S, Sun K, Robertson ES
PLoS pathogens 2019 Jun;15(6):e1007796
PLoS pathogens 2019 Jun;15(6):e1007796
Epitranscriptomic m(6)A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, Dore LC, Dong Q, Zheng W, Jin P, Wu H, Shen B, Zhuang X, He C, Liu K, Song H, Ming GL
Neuron 2018 Jan 17;97(2):313-325.e6
Neuron 2018 Jan 17;97(2):313-325.e6
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