26158-1-AP

antibody from Proteintech Group

Targeting: METTL14 KIAA1627

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

26158-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#26158-1-AP, RRID:AB_2800447

Product name

METTL14 antibody

Antibody type

Polyclonal

Description

KD/KO validated METTL14 antibody (Cat. #26158-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

N6-methyladenosine-modified circ_0000337 sustains bortezomib resistance in multiple myeloma by regulating DNA repair.

Jiang S, Gao L, Li J, Zhang F, Zhang Y, Liu J
Frontiers in cell and developmental biology 2024;12:1383232

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METTL14-mediated methylation of SLC25A3 mitigates mitochondrial damage in osteoblasts, leading to the improvement of osteoporosis.

Wang P, Zhou W, Chen F, Zhang X, Zhang Q, Chen Y, Zhang N
Experimental gerontology 2024 Sep;194:112496

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METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m(6)A-dependent manner.

Chen L, Hu Y, Zhang M, Liu L, Ma J, Xu Z, Zhang J, Gu H, Chen K
Aging cell 2024 May;23(5):e14123

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Palmatine inhibits expression fat mass and obesity associated protein (FTO) and exhibits a curative effect in dextran sulfate sodium (DSS)-induced experimental colitis.

Ji W, Huo Y, Zhang Y, Qian X, Ren Y, Hu C, Zhang J
International immunopharmacology 2024 May 10;132:111968

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Classical swine fever virus non-structural protein 5B hijacks host METTL14-mediated m6A modification to counteract host antiviral immune response.

Chen J, Song HX, Hu JH, Bai JS, Li XH, Sun RC, Zhao BQ, Li MZ, Zhou B
PLoS pathogens 2024 Mar;20(3):e1012130

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HNRNPA2B1 and HNRNPR stabilize ASCL1 in an m6A-dependent manner to promote neuroblastoma progression.

Hu T, Zeng C, Song Z, Liu Q, Chen S, Huang W, Ma Q, Li H
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167050

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IGF2BP3-stabilized CAMK1 regulates the mitochondrial dynamics of renal tubule to alleviate diabetic nephropathy.

Yuan D, Li H, Dai W, Zhou X, Zhou W, He L
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167022

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METTL3-mediated m(6)A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition.

Feng ZW, Peng B, Wang SH, Zhao DC, Wang YB, Yang A, Zhan HW, Sheng XY, Xu LH, Ren XJ, Yang F, Geng B, Xia YY
Cellular signalling 2024 Mar;115:111038

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Landscape of transcriptome-wide m(6)A modification in diabetic liver reveals rewiring of PI3K-Akt signaling after physical exercise.

Chen C, Jiang C, Lin T, Hu Y, Wu H, Xiang Q, Yang M, Wang S, Han X, Tao J
Acta physiologica (Oxford, England) 2024 Jun;240(6):e14154

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CircUGGT2 downregulation by METTL14-dependent m(6)A modification suppresses gastric cancer progression and cisplatin resistance through interaction with miR-186-3p/MAP3K9 axis.

Chen XY, Yang YL, Yu Y, Chen ZY, Fan HN, Zhang J, Zhu JS
Pharmacological research 2024 Jun;204:107206

---

Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.

Hu W, Wang M, Sun G, Zhang L, Lu H
Cellular signalling 2024 Jun;118:111139

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The m(6)A methyltransferase METTL3 drives neuroinflammation and neurotoxicity through stabilizing BATF mRNA in microglia.

Wu X, Liu H, Wang J, Zhang S, Hu Q, Wang T, Cui W, Shi Y, Bai H, Zhou J, Han L, Li L, Zhao T, Wu Y, Luo J, Feng D, Guo W, Ge S, Qu Y
Cell death and differentiation 2024 Jun 20;

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Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.

Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435

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METTL3 and METTL14 regulate IL-6 expression via RNA m6A modification of zinc transporter SLC39A9 and DNA methylation of IL-6 in periodontal ligament cells.

Huang J, Wang Y, Zhou Y
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119605

---

Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.

Fang X, Ao X, Xiao D, Wang Y, Jia Y, Wang P, Li M, Wang J
Cellular & molecular biology letters 2024 Jan 3;29(1):3

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Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.

Dai W, Tian R, Yu L, Bian S, Chen Y, Yin B, Luan Y, Chen S, Fan Z, Yan R, Pan X, Hou Y, Li R, Chen J, Shu M
Nature communications 2024 Jan 2;15(1):131

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FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation.

Chen K, Wang Y, Dai X, Luo J, Hu S, Zhou Z, Shi J, Pan X, Cao T, Xia J, Li Y, Wang Z, Ma J
Cell death & disease 2024 Jan 12;15(1):37

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METTL14 enhances the m6A modification level of lncRNA MSTRG.292666.16 to promote the progression of non-small cell lung cancer.

Ji X, Wan X, Sun H, Deng Q, Meng S, Xie B, Zhou S
Cancer cell international 2024 Feb 7;24(1):61

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The ARID1A-METTL3-m6A axis ensures effective RNase H1-mediated resolution of R-loops and genome stability.

Zhang J, Chen F, Tang M, Xu W, Tian Y, Liu Z, Shu Y, Yang H, Zhu Q, Lu X, Peng B, Liu X, Xu X, Gullerova M, Zhu WG
Cell reports 2024 Feb 27;43(2):113779

---

Highly pathogenic PRRSV upregulates IL-13 production through nonstructural protein 9-mediated inhibition of N6-methyladenosine demethylase FTO.

Gong X, Liang Y, Wang J, Pang Y, Wang F, Chen X, Zhang Q, Song C, Wang Y, Zhang C, Fang X, Chen X
The Journal of biological chemistry 2024 Apr;300(4):107199

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RBMS1 Coordinates with the m(6)A Reader YTHDF1 to Promote NSCLC Metastasis through Stimulating S100P Translation.

Sun Y, Chen D, Sun S, Ren M, Zhou L, Chen C, Zhao J, Wei H, Zhao Q, Qi Y, Zhang J, Zhang G, Liu H, Yang Q, Liu Q, Wang Y, Zhang W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(15):e2307122

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A LATS2 and ALKBH5 positive feedback loop supports their oncogenic roles.

Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, Li T, Zhao X, Lei L, Zhao Q, Liu D, Wang B, Wu X
Cell reports 2024 Apr 23;43(4):114032

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Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression.

Qiao Y, Su M, Zhao H, Liu H, Wang C, Dai X, Liu L, Liu G, Sun H, Sun M, Wang J, Li Z, Fan J, Zhang Q, Li C, Situ F, Xue J, Jia Z, Zhang C, Zhang S, Shan C
Journal of experimental & clinical cancer research : CR 2024 Apr 10;43(1):108

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Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.

Guan S, Chen X, Wei Y, Wang F, Xie W, Chen Y, Liang H, Zhu X, Yang Y, Fang W, Huang Y, Zhao H, Zhang X, Liu S, Zhuang W, Huang M, Wang X, Zhang L
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396

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METTL14 Regulates PLAGL2/β-Catenin Signaling Axis to Promote the Development of Nonsmall Cell Lung Cancer.

Zhou Q, Lai X, Gao Y, Chen Q, Xu Y, Liu Y
Journal of oncology 2023;2023:4738586

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Suppression of Wnt/β-catenin Signaling in PDAC via METTL16-mediated N6-methyladenosine Modification of DVL2.

Yu L, Lu J, Xie N, Fang L, Chen S, Wu Y, Wang X, Li B
Journal of Cancer 2023;14(16):2964-2977

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IGF2BP2-modified UBE2D1 interacts with Smad2/3 to promote the progression of breast cancer.

Guan XQ, Yuan XN, Feng KX, Shao YC, Liu Q, Yang ZL, Chen YY, Deng J, Hu MS, Li J, Tian YH, Chu MF, Zhang JW, Wei L
American journal of cancer research 2023;13(7):2948-2968

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Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma.

Li X, Fang J, Tao X, Xia J, Cheng B, Wang Y
PeerJ 2023;11:e14824

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ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression.

An X, Wu W, Yang L, Dong J, Liu B, Guo J, Chen J, Guo B, Cao W, Jiang Q
Translational research : the journal of laboratory and clinical medicine 2023 Sep;259:62-71

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HPV E7-drived ALKBH5 promotes cervical cancer progression by modulating m6A modification of PAK5.

Huo FC, Zhu ZM, Du WQ, Pan YJ, Jiang X, Kang MJ, Liu BW, Mou J, Pei DS
Pharmacological research 2023 Sep;195:106863

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AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance.

Qiu T, Wu C, Yao X, Han Q, Wang N, Yuan W, Zhang J, Shi Y, Jiang L, Liu X, Yang G, Sun X
Cell biology and toxicology 2023 Oct;39(5):2165-2181

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Differential epitranscriptome and proteome modulation in the brain of neonatal mice exposed to isoflurane or sevoflurane.

Wu Y, Yang Z, Su S, Xu X, Li Y, Li X, Gao Y, Sun D, Wan S, Pen M, Jin W, Ke C
Cell biology and toxicology 2023 Oct;39(5):2133-2148

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WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.

Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931

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Mettl3 induced miR-338-3p expression in dendritic cells promotes antigen-specific Th17 cell response via regulation of Dusp16.

Wei Y, Yang C, Liu Y, Sun D, Li X, Wei R, Nian H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23277

---

Macrophage membrane-coated nanovesicles for dual-targeted drug delivery to inhibit tumor and induce macrophage polarization.

Huang X, Wang L, Guo H, Zhang W
Bioactive materials 2023 May;23:69-79

---

Epigenetically silenced lncRNA SNAI3-AS1 promotes ferroptosis in glioma via perturbing the m(6)A-dependent recognition of Nrf2 mRNA mediated by SND1.

Zheng J, Zhang Q, Zhao Z, Qiu Y, Zhou Y, Wu Z, Jiang C, Wang X, Jiang X
Journal of experimental & clinical cancer research : CR 2023 May 19;42(1):127

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Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells.

Huang J, Guo C, Wang Y, Zhou Y
Tissue & cell 2023 Jun;82:102081

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Exercise Mitigates Endothelial Pyroptosis and Atherosclerosis by Downregulating NEAT1 Through N6-Methyladenosine Modifications.

Yang Q, Chen S, Wang X, Yang X, Chen L, Huang T, Zheng Y, Zheng X, Wu X, Sun Y, Wu J
Arteriosclerosis, thrombosis, and vascular biology 2023 Jun;43(6):910-926

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Newcastle disease virus activates methylation-related enzymes to reprogram m(6)A methylation in infected cells.

Yuan W, Hou Y, Wang Q, Lv T, Ren J, Fan L, Cai J, Xiang B, Lin Q, Liao M, Ding C, Chen L, Ren T
Veterinary microbiology 2023 Jun;281:109747

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FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Li B, Xi W, Bai Y, Liu X, Zhang Y, Li L, Bian L, Liu C, Tang Y, Shen L, Yang L, Gu X, Xie J, Zhou Z, Wang Y, Yu X, Wang J, Chao J, Han B, Yao H
Nature communications 2023 Jan 30;14(1):489

---

The miR-27a-3p/FTO axis modifies hypoxia-induced malignant behaviors of glioma cells.

Du P, Meng L, Liao X, Liu Y, Mo X, Gong M, Liao Y
Acta biochimica et biophysica Sinica 2023 Jan 25;55(1):103-116

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NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Wang Y, Zhang L, Sun XL, Lu YC, Chen S, Pei DS, Zhang LS
Apoptosis : an international journal on programmed cell death 2023 Feb;28(1-2):233-246

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ALKBH1-mediated m(1) A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression.

Chen W, Wang H, Mi S, Shao L, Xu Z, Xue M
Molecular oncology 2023 Feb;17(2):344-364

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Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.

Chen Y, Liu X, Li L, He X, Zheng F, Zhang Y, Gao H, Jin Z, Wu D, Wang Q, Tao H, Zhao Y, Liu W, Zou L
Molecular medicine (Cambridge, Mass.) 2023 Feb 6;29(1):19

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Heterogeneous Nuclear Protein U Degraded the m(6)A Methylated TRAF3 Transcript by YTHDF2 To Promote Porcine Epidemic Diarrhea Virus Replication.

Zhou H, Yan Y, Gao J, Ma M, Liu Y, Shi X, Zhang Q, Xu X
Journal of virology 2023 Feb 28;97(2):e0175122

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METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.

Sun K, Chen L, Li Y, Huang B, Yan Q, Wu C, Lai Q, Fang Y, Cai J, Liu Y, Chen J, Wang X, Zhu Y, Dong S, Tan J, Li A, Liu S, Zhang Y
Cell death & disease 2023 Feb 21;14(2):148

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m (6) A RNA methylation orchestrates transcriptional dormancy during developmental pausing.

Collignon E, Cho B, Fothergill-Robinson J, Furlan G, Ross RL, Limbach PA, Ramalho-Santos M
bioRxiv : the preprint server for biology 2023 Feb 1;

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Downregulation of ALKBH5 rejuvenates aged human mesenchymal stem cells and enhances their therapeutic efficacy in myocardial infarction.

Gao X, Liang X, Liu B, Hong Y, He H, Shen Y, Chen J, Huang X, Hu B, Li W, Li X, Zhang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Dec;37(12):e23294

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METTL14-m6A-FOXO3a axis regulates autophagy and inflammation in ankylosing spondylitis.

Chen Y, Wu Y, Fang L, Zhao H, Xu S, Shuai Z, Yu H, Cai G, Zhan HQ, Pan F
Clinical immunology (Orlando, Fla.) 2023 Dec;257:109838

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EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.

Lv D, Zhong C, Dixit D, Yang K, Wu Q, Godugu B, Prager BC, Zhao G, Wang X, Xie Q, Bao S, He C, Heiland DH, Rosenfeld MG, Rich JN
Molecular cell 2023 Dec 7;83(23):4334-4351.e7

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m(6)A methylation-mediated PGC-1α contributes to ferroptosis via regulating GSTK1 in arsenic-induced hepatic insulin resistance.

Zhang J, Song J, Liu S, Zhang Y, Qiu T, Jiang L, Bai J, Yao X, Wang N, Yang G, Sun X
The Science of the total environment 2023 Dec 20;905:167202

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Coilin mediates m6A RNA methylation through phosphorylation of METTL3.

McLaurin DM, Tucker SK, Hebert MD
Biology open 2023 Dec 15;12(12)

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Specific Regulation of m(6)A by SRSF7 Promotes the Progression of Glioblastoma.

Cun Y, An S, Zheng H, Lan J, Chen W, Luo W, Yao C, Li X, Huang X, Sun X, Wu Z, Hu Y, Li Z, Zhang S, Wu G, Yang M, Tang M, Yu R, Liao X, Gao G, Zhao W, Wang J, Li J
Genomics, proteomics & bioinformatics 2023 Aug;21(4):707-728

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Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.

Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821

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WTAP-mediated m6A modification of IFNE is required for antiviral defense in condyloma acuminata.

Gu Z, Liu J, Qin L, Zhang Y, Cui W, Huang H, Liu L, Cao Y, Zhang H
Journal of dermatological science 2023 Aug;111(2):43-51

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Characterization of m(6)A modifiers and RNA modifications in uterine fibroids.

George JW, Cancino RA, Miller JLG, Qiu F, Lin Q, Rowley MJ, Chennathukuzhi VM, Davis JS
bioRxiv : the preprint server for biology 2023 Aug 9;

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A cleaved METTL3 potentiates the METTL3-WTAP interaction and breast cancer progression.

Yan C, Xiong J, Zhou Z, Li Q, Gao C, Zhang M, Yu L, Li J, Hu MM, Zhang CS, Cai C, Zhang H, Zhang J
eLife 2023 Aug 17;12

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METTL3-mediated m6A mRNA modification was involved in cadmium-induced liver injury.

Li W, Tan M, Wang H, Wang Z, Pang Y, Yang R, Zhong S, Pan X, Chen S, Wang Q, Li D, Xiao Y, Chen W, Chen L
Environmental pollution (Barking, Essex : 1987) 2023 Aug 15;331(Pt 2):121887

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METTL14 reverses liver fibrosis by inhibiting NOVA2 through an m6A-YTHDF2-dependent mechanism.

Hou X, Li Y, Song J, Peng L, Zhang W, Liu R, Yuan H, Feng T, Li J, Li W, Zhu C
Hepatology communications 2023 Aug 1;7(8)

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Comprehensive analyses of molecular features, prognostic values, and regulatory functionalities of m(6)A-modified long non-coding RNAs in lung adenocarcinoma.

Ping Y, Huang J, Zhu J, Sun Z, Shang A, Chen C, Liu W, Li D
Clinical epigenetics 2023 Apr 7;15(1):60

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METTL14 Regulates Intestine Cellular Senescence through m(6)A Modification of Lamin B Receptor.

Zhang Z, Xue M, Chen J, Wang Z, Ju F, Ni J, Sun J, Wu H, Zheng H, Lou Z, Zhang Y, Yang X, Chen S, Xi Y, Wang L
Oxidative medicine and cellular longevity 2022;2022:9096436

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YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.

Li Z, Teng M, Jiang Y, Zhang L, Luo X, Liao Y, Yang B
Frontiers in immunology 2022;13:857727

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METTL3 acetylation impedes cancer metastasis via fine-tuning its nuclear and cytosolic functions.

Li Y, He X, Lu X, Gong Z, Li Q, Zhang L, Yang R, Wu C, Huang J, Ding J, He Y, Liu W, Chen C, Cao B, Zhou D, Shi Y, Chen J, Wang C, Zhang S, Zhang J, Ye J, You H
Nature communications 2022 Oct 26;13(1):6350

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Adenosine N(6)-methylation upregulates the expression of human CYP2B6 by altering the chromatin status.

Isono M, Nakano M, Fukami T, Nakajima M
Biochemical pharmacology 2022 Nov;205:115247

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Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

Yang Y, Qian Cai Q, Sheng Fu L, Wei Dong Y, Fan F, Zhong Wu X
Chemistry & biodiversity 2022 Nov;19(11):e202200333

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N6-methyladenosine reader YTHDF3 regulates melanoma metastasis via its 'executor'LOXL3.

Shi HZ, Xiong JS, Gan L, Zhang Y, Zhang CC, Kong YQ, Miao QJ, Tian CC, Li R, Liu JQ, Zhang EJ, Bu WB, Wang Y, Cheng XF, Sun JF, Chen H
Clinical and translational medicine 2022 Nov;12(11):e1075

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Systematic analysis of the expression profile and prognostic significance of m6A regulators and PD-L1 in hepatocellular carcinoma.

Kong F, Wang K, Wang L
Discover oncology 2022 Nov 25;13(1):131

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Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.

Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615

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Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant m6A RNA modification in head and neck squamous cell carcinoma.

Chen X, Liu Y, Sun D, Sun R, Wang X, Li M, Song N, Ying J, Guo T, Jiang Y
Cancer science 2022 Jun;113(6):2071-2084

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DDX5/METTL3-METTL14/YTHDF2 Axis Regulates Replication of Influenza A Virus.

Zhao L, Zhao Y, Liu Q, Huang J, Lu Y, Ping J
Microbiology spectrum 2022 Jun 29;10(3):e0109822

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PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.

Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6

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The genomic landscape of cholangiocarcinoma reveals the disruption of post-transcriptional modifiers.

Zhang Y, Ma Z, Li C, Wang C, Jiang W, Chang J, Han S, Lu Z, Shao Z, Wang Y, Wang H, Jiao C, Wang D, Wu X, Shen H, Wang X, Hu Z, Li X
Nature communications 2022 Jun 1;13(1):3061

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Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.

Liu Z, Cai Y, Deng M, Li D, Leng Q, Shi L, Tang Y, Wang F, Wan Y
Cell and tissue research 2022 Jan;387(1):131-142

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m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.

Gao M, Qi Z, Feng W, Huang H, Xu Z, Dong Z, Xu M, Han J, Kloeber JA, Huang J, Lou Z, Liu S
The Journal of biological chemistry 2022 Feb;298(2):101563

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The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Li M, Zhong X, Zhao Z, Zeng Z, Yuan Q, Xiao X, Zu X, Liu J
Brain research 2022 Feb 15;1777:147766

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Mechanism of METTL14-mediated m(6)A modification in non-small cell lung cancer cell resistance to cisplatin.

Gong S, Wang S, Shao M
Journal of molecular medicine (Berlin, Germany) 2022 Dec;100(12):1771-1785

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The landscape of m6A regulators in esophageal cancer: molecular characteristics, immuno-oncology features, and clinical relevance.

Li Z, Zheng C, Huang L, Yin X, Wang Z, Liu C, Li B
Annals of translational medicine 2022 Dec;10(24):1347

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PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.

Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y
The EMBO journal 2022 Aug 16;41(16):e110439

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Novel prognostic biomarkers, METTL14 and YTHDF2, associated with RNA methylation in Ewing's sarcoma.

Jiang J, Fan Q, Qu H, Liu C, Liang T, Chen L, Huang S, Sun X, Chen J, Chen T, Li H, Yao Y, Zhan X
Scientific reports 2022 Apr 29;12(1):7041

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Mettl14-Mediated m6A Modification Is Essential for Germinal Center B Cell Response.

Huang H, Zhang G, Ruan GX, Li Y, Chen W, Zou J, Zhang R, Wang J, Ji SJ, Xu S, Ou X
Journal of immunology (Baltimore, Md. : 1950) 2022 Apr 15;208(8):1924-1936

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Methylation and Expression of the Exercise-Related TLR1 Gene Is Associated With Low Grade Glioma Prognosis and Outcome.

Lu L, Hu Y, Wang C, Jiang F, Wu C
Frontiers in molecular biosciences 2021;8:747933

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MMP24 Contributes to Neuropathic Pain in an FTO-Dependent Manner in the Spinal Cord Neurons.

Ma L, Huang Y, Zhang F, Gao DS, Sun N, Ren J, Xia S, Li J, Peng X, Yu L, Jiang BC, Yan M
Frontiers in pharmacology 2021;12:673831

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Identification and Validation of m6A-Related lncRNA Signature as Potential Predictive Biomarkers in Breast Cancer.

Lv W, Wang Y, Zhao C, Tan Y, Xiong M, Yi Y, He X, Ren Y, Wu Y, Zhang Q
Frontiers in oncology 2021;11:745719

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Stimulation of Let-7 Maturation by Metformin Improved the Response to Tyrosine Kinase Inhibitor Therapy in an m6A Dependent Manner.

Li K, Gao S, Ma L, Sun Y, Peng ZY, Wu J, Du N, Ren H, Tang SC, Sun X
Frontiers in oncology 2021;11:731561

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M6A "Writer" Gene METTL14: A Favorable Prognostic Biomarker and Correlated With Immune Infiltrates in Rectal Cancer.

Cai C, Long J, Huang Q, Han Y, Peng Y, Guo C, Liu S, Chen Y, Shen E, Long K, Wang X, Yu J, Shen H, Zeng S
Frontiers in oncology 2021;11:615296

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m(6)A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2.

Takemoto S, Nakano M, Fukami T, Nakajima M
Biochemical pharmacology 2021 Nov;193:114766

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Isorhapontigenin (ISO) inhibits EMT through FOXO3A/METTL14/VIMENTIN pathway in bladder cancer cells.

Zhang N, Hua X, Tu H, Li J, Zhang Z, Max C
Cancer letters 2021 Nov 1;520:400-408

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mTORC1 stimulates cell growth through SAM synthesis and m(6)A mRNA-dependent control of protein synthesis.

Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I
Molecular cell 2021 May 20;81(10):2076-2093.e9

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Oncogenic AURKA-enhanced N(6)-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells.

Peng F, Xu J, Cui B, Liang Q, Zeng S, He B, Zou H, Li M, Zhao H, Meng Y, Chen J, Liu B, Lv S, Chu P, An F, Wang Z, Huang J, Zhan Y, Liao Y, Lu J, Xu L, Zhang J, Sun Z, Li Z, Wang F, Lam EW, Liu Q
Cell research 2021 Mar;31(3):345-361

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AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.

Bian X, Shi D, Xing K, Zhou H, Lu L, Yu D, Wu W
Clinical and translational medicine 2021 Mar;11(3):e352

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The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.

Ondo K, Isono M, Nakano M, Hashiba S, Fukami T, Nakajima M
Biochemical pharmacology 2021 Jul;189:114402

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Knockdown of METTL14 suppresses the malignant progression of non-small cell lung cancer by reducing Twist expression.

Yang F, Yuan WQ, Li J, Luo YQ
Oncology letters 2021 Dec;22(6):847

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YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells.

Zhu X, Yang H, Zhang M, Wu X, Jiang L, Liu X, Lv K
Cancer cell international 2021 Dec 4;21(1):645

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ALKBH5-mediated m(6)A demethylation of KCNK15-AS1 inhibits pancreatic cancer progression via regulating KCNK15 and PTEN/AKT signaling.

He Y, Yue H, Cheng Y, Ding Z, Xu Z, Lv C, Wang Z, Wang J, Yin C, Hao H, Chen C
Cell death & disease 2021 Dec 1;12(12):1121

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The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.

Ma S, Yan J, Barr T, Zhang J, Chen Z, Wang LS, Sun JC, Chen J, Caligiuri MA, Yu J
The Journal of experimental medicine 2021 Aug 2;218(8)

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The m(6)A methylome of SARS-CoV-2 in host cells.

Liu J, Xu YP, Li K, Ye Q, Zhou HY, Sun H, Li X, Yu L, Deng YQ, Li RT, Cheng ML, He B, Zhou J, Li XF, Wu A, Yi C, Qin CF
Cell research 2021 Apr;31(4):404-414

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METTL14 Inhibits Hepatocellular Carcinoma Metastasis Through Regulating EGFR/PI3K/AKT Signaling Pathway in an m6A-Dependent Manner.

Shi Y, Zhuang Y, Zhang J, Chen M, Wu S
Cancer management and research 2020;12:13173-13184

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The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA.

Gao XQ, Zhang YH, Liu F, Ponnusamy M, Zhao XM, Zhou LY, Zhai M, Liu CY, Li XM, Wang M, Shan C, Shan PP, Wang Y, Dong YH, Qian LL, Yu T, Ju J, Wang T, Wang K, Chen XZ, Wang YH, Zhang J, Li PF, Wang K
Nature cell biology 2020 Nov;22(11):1319-1331

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Analysis of METTL3 and METTL14 in hepatocellular carcinoma.

Liu X, Qin J, Gao T, Li C, Chen X, Zeng K, Xu M, He B, Pan B, Xu X, Pan Y, Sun H, Xu T, Wang S
Aging 2020 Nov 6;12(21):21638-21659

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ANKLE1 N(6) -Methyladenosine-related variant is associated with colorectal cancer risk by maintaining the genomic stability.

Tian J, Ying P, Ke J, Zhu Y, Yang Y, Gong Y, Zou D, Peng X, Yang N, Wang X, Mei S, Zhang Y, Wang C, Zhong R, Chang J, Miao X
International journal of cancer 2020 Jun 15;146(12):3281-3293

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Alteration of N(6)-methyladenosine epitranscriptome profile in unilateral ureteral obstructive nephropathy.

Li X, Fan X, Yin X, Liu H, Yang Y
Epigenomics 2020 Jul;12(14):1157-1173

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Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy.

Li G, Song Y, Liao Z, Wang K, Luo R, Lu S, Zhao K, Feng X, Liang H, Ma L, Wang B, Ke W, Yin H, Zhan S, Li S, Wu X, Zhang Y, Yang C
Cell death & disease 2020 Feb 6;11(2):103

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Expression and Prognostic Significance of m6A-Related Genes in Lung Adenocarcinoma.

Zhang Y, Liu X, Liu L, Li J, Hu Q, Sun R
Medical science monitor : international medical journal of experimental and clinical research 2020 Feb 22;26:e919644

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m(6)A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.

Wang Y, Sun J, Lin Z, Zhang W, Wang S, Wang W, Wang Q, Ning G
Diabetes 2020 Aug;69(8):1708-1722

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AMPK facilitates intestinal long-chain fatty acid uptake by manipulating CD36 expression and translocation.

Wu W, Wang S, Liu Q, Shan T, Wang X, Feng J, Wang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):4852-4869

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Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.

Geng F, Fan MJ, Li J, Liang SM, Li CY, Li N
Translational cancer research 2019 Oct;8(6):2307-2315

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Viral N(6)-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus.

Xue M, Zhao BS, Zhang Z, Lu M, Harder O, Chen P, Lu Z, Li A, Ma Y, Xu Y, Liang X, Zhou J, Niewiesk S, Peeples ME, He C, Li J
Nature communications 2019 Oct 9;10(1):4595

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EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.

Lang F, Singh RK, Pei Y, Zhang S, Sun K, Robertson ES
PLoS pathogens 2019 Jun;15(6):e1007796

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Epitranscriptomic m(6)A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.

Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, Dore LC, Dong Q, Zheng W, Jin P, Wu H, Shen B, Zhuang X, He C, Liu K, Song H, Ming GL
Neuron 2018 Jan 17;97(2):313-325.e6