Antibody data
- Antibody Data
- Antigen structure
- References [69]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 12586-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12586-1-AP, RRID:AB_2183496
- Product name
- SAMHD1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SAMHD1 antibody (Cat. #12586-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SAMHD1 expression is a surrogate marker of immune infiltration and determines prognosis after neoadjuvant chemotherapy in early breast cancer.
SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells.
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis.
Abemaciclib restricts HCMV replication by suppressing pUL97-mediated phosphorylation of SAMHD1.
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels.
Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA.
IP6-stabilised HIV capsids evade cGAS/STING-mediated host immune sensing.
iPS cell-derived model to study the interaction between tissue macrophage and HIV-1.
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels.
Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import.
Inhibitory and Stimulatory Effects of IL-32 on HIV-1 Infection.
SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway.
1,25(OH)(2)D(3) Promotes Macrophage Efferocytosis Partly by Upregulating ASAP2 Transcription via the VDR-Bound Enhancer Region and ASAP2 May Affect Antiviral Immunity.
Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma.
Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML.
Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types.
Human cytomegalovirus UL24 and UL43 products participate in SAMHD1 subcellular localization.
N6-methyladenosine demethylase FTO regulates inflammatory cytokine secretion and tight junctions in retinal pigment epithelium cells.
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.
Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.
SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir.
Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA.
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages.
Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy.
SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine.
SAMHD1-deficient fibroblasts from Aicardi-Goutières Syndrome patients can escape senescence and accumulate mutations.
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Insights into Innate Sensing of Prototype Foamy Viruses in Myeloid Cells.
Interference with SAMHD1 Restores Late Gene Expression of Modified Vaccinia Virus Ankara in Human Dendritic Cells and Abrogates Type I Interferon Expression.
Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner.
Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592.
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens.
USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.
Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages.
DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci.
Inhibition of HIV early replication by the p53 and its downstream gene p21.
T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
SAMHD1 is active in cycling cells permissive to HIV-1 infection.
Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection.
Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells.
Interferon-stimulated gene factor 3 complex is required for the induction of sterile α motif and HD domain-containing protein 1 expression by interferon-α in SMMC-7721 cells.
Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans.
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
SAMHD1 prevents autoimmunity by maintaining genome stability.
SAMHD1's protein expression profile in humans.
HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells.
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity.
Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells.
Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.
Inhibition of Hepatitis B virus replication by SAMHD1.
SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells.
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells.
Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression.
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response.
Gutiérrez-Chamorro L, Felip E, Castellà E, Quiroga V, Ezeonwumelu IJ, Angelats L, Esteve A, Perez-Roca L, Martínez-Cardús A, Fernandez PL, Ferrando-Díez A, Pous A, Bergamino M, Cirauqui B, Romeo M, Teruel I, Mesia R, Clotet B, Riveira-Muñoz E, Margelí M, Ballana E
Cellular oncology (Dordrecht, Netherlands) 2024 Feb;47(1):189-208
Cellular oncology (Dordrecht, Netherlands) 2024 Feb;47(1):189-208
SAMHD1 dysfunction induces IL-34 expression via NF-κB p65 in neuronal SH-SY5Y cells.
Zhang L, Wang W, Chen T, Cui J, Li X, Liu A, Liu R, Fang L, Jiang J, Yang L, Wu D, Ying S
Molecular immunology 2024 Apr;168:1-9
Molecular immunology 2024 Apr;168:1-9
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma.
Cai Y, Chen X, Lu T, Fang X, Ding M, Yu Z, Hu S, Liu J, Zhou X, Wang X
International journal of biological sciences 2023;19(14):4627-4643
International journal of biological sciences 2023;19(14):4627-4643
SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis.
Gutiérrez-Chamorro L, Felip E, Bernat-Peguera A, Ezeonwumelu IJ, Teruel I, Martínez-Cardús A, Clotet B, Riveira-Muñoz E, Romeo M, Margelí M, Ballana E
Frontiers in immunology 2023;14:1112761
Frontiers in immunology 2023;14:1112761
Abemaciclib restricts HCMV replication by suppressing pUL97-mediated phosphorylation of SAMHD1.
Syrigos GV, Feige M, Dirlam A, Businger R, Gruska I, Wiebusch L, Hamprecht K, Schindler M
Antiviral research 2023 Sep;217:105689
Antiviral research 2023 Sep;217:105689
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels.
Schüssler M, Schott K, Fuchs NV, Oo A, Zahadi M, Rauch P, Kim B, König R
mBio 2023 Oct 31;14(5):e0225223
mBio 2023 Oct 31;14(5):e0225223
Human Papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA.
James CD, Youssef A, Prabhakar AT, Otoa R, Witt A, Lewis RL, Bristol ML, Wang X, Zhang K, Li R, Morgan IM
bioRxiv : the preprint server for biology 2023 Nov 15;
bioRxiv : the preprint server for biology 2023 Nov 15;
IP6-stabilised HIV capsids evade cGAS/STING-mediated host immune sensing.
Papa G, Albecka A, Mallery D, Vaysburd M, Renner N, James LC
EMBO reports 2023 May 4;24(5):e56275
EMBO reports 2023 May 4;24(5):e56275
iPS cell-derived model to study the interaction between tissue macrophage and HIV-1.
Eltalkhawy YM, Takahashi N, Ariumi Y, Shimizu J, Miyazaki K, Senju S, Suzu S
Journal of leukocyte biology 2023 Jul 1;114(1):53-67
Journal of leukocyte biology 2023 Jul 1;114(1):53-67
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels.
Schüssler M, Schott K, Fuchs NV, Oo A, Zahadi M, Rauch P, Kim B, König R
bioRxiv : the preprint server for biology 2023 Aug 25;
bioRxiv : the preprint server for biology 2023 Aug 25;
Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import.
Mann JR, McKenna ED, Mawrie D, Papakis V, Alessandrini F, Anderson EN, Mayers R, Ball HE, Kaspi E, Lubinski K, Baron DM, Tellez L, Landers JE, Pandey UB, Kiskinis E
Science advances 2023 Aug 18;9(33):eadi5548
Science advances 2023 Aug 18;9(33):eadi5548
Inhibitory and Stimulatory Effects of IL-32 on HIV-1 Infection.
Nasser H, Takahashi N, Eltalkhawy YM, Reda O, Lotfi S, Nasu K, Sakuragi JI, Suzu S
Journal of immunology (Baltimore, Md. : 1950) 2022 Sep 1;209(5):970-978
Journal of immunology (Baltimore, Md. : 1950) 2022 Sep 1;209(5):970-978
SAMHD1, positively regulated by KLF4, suppresses the proliferation of gastric cancer cells through MAPK p38 signaling pathway.
Chen Z, Jiang Z, Meng L, Wang Y, Lin M, Wei Z, Han W, Ying S, Xu A
Cell cycle (Georgetown, Tex.) 2022 Oct;21(19):2065-2078
Cell cycle (Georgetown, Tex.) 2022 Oct;21(19):2065-2078
1,25(OH)(2)D(3) Promotes Macrophage Efferocytosis Partly by Upregulating ASAP2 Transcription via the VDR-Bound Enhancer Region and ASAP2 May Affect Antiviral Immunity.
Shi H, Duan J, Wang J, Li H, Wu Z, Wang S, Wu X, Lu M
Nutrients 2022 Nov 21;14(22)
Nutrients 2022 Nov 21;14(22)
Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma.
Merrien M, Wasik AM, Ljung E, Morsy MHA, de Matos Rodrigues J, Carlsten M, Rassidakis GZ, Christensson B, Kolstad A, Jerkeman M, Ek S, Herold N, Wahlin BE, Sander B
Virchows Archiv : an international journal of pathology 2022 Mar;480(3):655-666
Virchows Archiv : an international journal of pathology 2022 Mar;480(3):655-666
Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML.
Zhang F, Sun J, Tang X, Liang Y, Jiao Q, Yu B, Dai Z, Yuan X, Li J, Yan J, Zhang Z, Fan S, Wang M, Hu H, Zhang C, Lv XB
Cell death & disease 2022 Jul 8;13(7):590
Cell death & disease 2022 Jul 8;13(7):590
Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types.
Felip E, Gutiérrez-Chamorro L, Gómez M, Garcia-Vidal E, Romeo M, Morán T, Layos L, Pérez-Roca L, Riveira-Muñoz E, Clotet B, Fernandez PL, Mesía R, Martínez-Cardús A, Ballana E, Margelí M
Cancers 2022 Jan 27;14(3)
Cancers 2022 Jan 27;14(3)
Human cytomegalovirus UL24 and UL43 products participate in SAMHD1 subcellular localization.
Sleman S, Najmuldeen H, Hao H, Jalal P, Saeed N, Othman D, Qian Z
Virusdisease 2022 Dec;33(4):383-396
Virusdisease 2022 Dec;33(4):383-396
N6-methyladenosine demethylase FTO regulates inflammatory cytokine secretion and tight junctions in retinal pigment epithelium cells.
Tang S, Meng J, Tan J, Liu X, Zhou H, Li N, Hou S
Clinical immunology (Orlando, Fla.) 2022 Aug;241:109080
Clinical immunology (Orlando, Fla.) 2022 Aug;241:109080
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.
Rothenburger T, Thomas D, Schreiber Y, Wratil PR, Pflantz T, Knecht K, Digianantonio K, Temple J, Schneider C, Baldauf HM, McLaughlin KM, Rothweiler F, Bilen B, Farmand S, Bojkova D, Costa R, Ferreirós N, Geisslinger G, Oellerich T, Xiong Y, Keppler OT, Wass MN, Michaelis M, Cinatl J Jr
Journal of experimental & clinical cancer research : CR 2021 Oct 12;40(1):317
Journal of experimental & clinical cancer research : CR 2021 Oct 12;40(1):317
Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.
Hiatt J, Cavero DA, McGregor MJ, Zheng W, Budzik JM, Roth TL, Haas KM, Wu D, Rathore U, Meyer-Franke A, Bouzidi MS, Shifrut E, Lee Y, Kumar VE, Dang EV, Gordon DE, Wojcechowskyj JA, Hultquist JF, Fontaine KA, Pillai SK, Cox JS, Ernst JD, Krogan NJ, Marson A
Cell reports 2021 May 11;35(6):109105
Cell reports 2021 May 11;35(6):109105
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.
Roider T, Wang X, Hüttl K, Müller-Tidow C, Klapper W, Rosenwald A, Stewart JP, de Castro DG, Dreger P, Hermine O, Kluin-Nelemans HC, Grabe N, Dreyling M, Pott C, Ott G, Hoster E, Dietrich S
International journal of cancer 2021 Jan 1;148(1):150-160
International journal of cancer 2021 Jan 1;148(1):150-160
SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.
De Meo S, Dell'Oste V, Molfetta R, Tassinari V, Lotti LV, Vespa S, Pignoloni B, Covino DA, Fantuzzi L, Bona R, Zingoni A, Nardone I, Biolatti M, Coscia A, Paolini R, Benkirane M, Edfors F, Sandalova T, Achour A, Hiscott J, Landolfo S, Santoni A, Cerboni C
PLoS pathogens 2020 Sep;16(9):e1008855
PLoS pathogens 2020 Sep;16(9):e1008855
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir.
Neidleman J, Luo X, Frouard J, Xie G, Hsiao F, Ma T, Morcilla V, Lee A, Telwatte S, Thomas R, Tamaki W, Wheeler B, Hoh R, Somsouk M, Vohra P, Milush J, James KS, Archin NM, Hunt PW, Deeks SG, Yukl SA, Palmer S, Greene WC, Roan NR
eLife 2020 Sep 29;9
eLife 2020 Sep 29;9
Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA.
Sumner RP, Harrison L, Touizer E, Peacock TP, Spencer M, Zuliani-Alvarez L, Towers GJ
The EMBO journal 2020 Oct 15;39(20):e103958
The EMBO journal 2020 Oct 15;39(20):e103958
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
Rudd SG, Tsesmetzis N, Sanjiv K, Paulin CB, Sandhow L, Kutzner J, Hed Myrberg I, Bunten SS, Axelsson H, Zhang SM, Rasti A, Mäkelä P, Coggins SA, Tao S, Suman S, Branca RM, Mermelekas G, Wiita E, Lee S, Walfridsson J, Schinazi RF, Kim B, Lehtiö J, Rassidakis GZ, Pokrovskaja Tamm K, Warpman-Berglund U, Heyman M, Grandér D, Lehmann S, Lundbäck T, Qian H, Henter JI, Schaller T, Helleday T, Herold N
EMBO molecular medicine 2020 Mar 6;12(3):e10419
EMBO molecular medicine 2020 Mar 6;12(3):e10419
TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages.
Mlcochova P, Winstone H, Zuliani-Alvarez L, Gupta RK
Cell reports 2020 Mar 24;30(12):3972-3980.e5
Cell reports 2020 Mar 24;30(12):3972-3980.e5
Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy.
Castellví M, Felip E, Ezeonwumelu IJ, Badia R, Garcia-Vidal E, Pujantell M, Gutiérrez-Chamorro L, Teruel I, Martínez-Cardús A, Clotet B, Riveira-Muñoz E, Margelí M, Ballana E
Cancers 2020 Mar 18;12(3)
Cancers 2020 Mar 18;12(3)
SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine.
Rothenburger T, McLaughlin KM, Herold T, Schneider C, Oellerich T, Rothweiler F, Feber A, Fenton TR, Wass MN, Keppler OT, Michaelis M, Cinatl J Jr
Communications biology 2020 Jun 24;3(1):324
Communications biology 2020 Jun 24;3(1):324
SAMHD1-deficient fibroblasts from Aicardi-Goutières Syndrome patients can escape senescence and accumulate mutations.
Franzolin E, Coletta S, Ferraro P, Pontarin G, D'Aronco G, Stevanoni M, Palumbo E, Cagnin S, Bertoldi L, Feltrin E, Valle G, Russo A, Bianchi V, Rampazzo C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):631-647
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):631-647
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Li Z, Huan C, Wang H, Liu Y, Liu X, Su X, Yu J, Zhao Z, Yu XF, Zheng B, Zhang W
EMBO reports 2020 Jan 7;21(1):e47528
EMBO reports 2020 Jan 7;21(1):e47528
Insights into Innate Sensing of Prototype Foamy Viruses in Myeloid Cells.
Bergez M, Weber J, Riess M, Erdbeer A, Seifried J, Stanke N, Munz C, Hornung V, König R, Lindemann D
Viruses 2019 Nov 26;11(12)
Viruses 2019 Nov 26;11(12)
Interference with SAMHD1 Restores Late Gene Expression of Modified Vaccinia Virus Ankara in Human Dendritic Cells and Abrogates Type I Interferon Expression.
Sliva K, Martin J, von Rhein C, Herrmann T, Weyrich A, Toda M, Schnierle BS
Journal of virology 2019 Nov 15;93(22)
Journal of virology 2019 Nov 15;93(22)
Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner.
Shakya AK, O'Callaghan DJ, Kim SK
Journal of virology 2019 Jun 15;93(12)
Journal of virology 2019 Jun 15;93(12)
Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.
Businger R, Deutschmann J, Gruska I, Milbradt J, Wiebusch L, Gramberg T, Schindler M
Nature microbiology 2019 Dec;4(12):2260-2272
Nature microbiology 2019 Dec;4(12):2260-2272
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
Osei Kuffour E, König R, Häussinger D, Schulz WA, Münk C
mBio 2019 Aug 27;10(4)
mBio 2019 Aug 27;10(4)
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Oellerich T, Schneider C, Thomas D, Knecht KM, Buzovetsky O, Kaderali L, Schliemann C, Bohnenberger H, Angenendt L, Hartmann W, Wardelmann E, Rothenburger T, Mohr S, Scheich S, Comoglio F, Wilke A, Ströbel P, Serve H, Michaelis M, Ferreirós N, Geisslinger G, Xiong Y, Keppler OT, Cinatl J Jr
Nature communications 2019 Aug 2;10(1):3475
Nature communications 2019 Aug 2;10(1):3475
The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592.
Tramentozzi E, Ferraro P, Hossain M, Stillman B, Bianchi V, Pontarin G
Cell cycle (Georgetown, Tex.) 2018;17(9):1102-1114
Cell cycle (Georgetown, Tex.) 2018;17(9):1102-1114
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Knecht KM, Buzovetsky O, Schneider C, Thomas D, Srikanth V, Kaderali L, Tofoleanu F, Reiss K, Ferreirós N, Geisslinger G, Batista VS, Ji X, Cinatl J Jr, Keppler OT, Xiong Y
Proceedings of the National Academy of Sciences of the United States of America 2018 Oct 23;115(43):E10022-E10031
Proceedings of the National Academy of Sciences of the United States of America 2018 Oct 23;115(43):E10022-E10031
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens.
Rassidakis GZ, Herold N, Myrberg IH, Tsesmetzis N, Rudd SG, Henter JI, Schaller T, Ng SB, Chng WJ, Yan B, Ng CH, Ravandi F, Andreeff M, Kantarjian HM, Medeiros LJ, Xagoraris I, Khoury JD
Blood cancer journal 2018 Oct 19;8(11):98
Blood cancer journal 2018 Oct 19;8(11):98
USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.
Osei Kuffour E, Schott K, Jaguva Vasudevan AA, Holler J, Schulz WA, Lang PA, Lang KS, Kim B, Häussinger D, König R, Münk C
Journal of virology 2018 Oct 15;92(20)
Journal of virology 2018 Oct 15;92(20)
Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages.
Bejarano DA, Puertas MC, Börner K, Martinez-Picado J, Müller B, Kräusslich HG
Viruses 2018 Nov 10;10(11)
Viruses 2018 Nov 10;10(11)
DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci.
Medeiros AC, Soares CS, Coelho PO, Vieira NA, Baqui MMA, Teixeira FR, Gomes MD
Biochemical and biophysical research communications 2018 May 23;499(4):790-796
Biochemical and biophysical research communications 2018 May 23;499(4):790-796
Inhibition of HIV early replication by the p53 and its downstream gene p21.
Shi B, Sharifi HJ, DiGrigoli S, Kinnetz M, Mellon K, Hu W, de Noronha CMC
Virology journal 2018 Mar 27;15(1):53
Virology journal 2018 Mar 27;15(1):53
T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.
Bolduan S, Koppensteiner H, Businger R, Rebensburg S, Kunze C, Brack-Werner R, Draenert R, Schindler M
Journal of the International AIDS Society 2017 Sep 19;20(1):21865
Journal of the International AIDS Society 2017 Sep 19;20(1):21865
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT
Proceedings of the National Academy of Sciences of the United States of America 2017 Mar 7;114(10):2729-2734
Proceedings of the National Academy of Sciences of the United States of America 2017 Mar 7;114(10):2729-2734
SAMHD1 is active in cycling cells permissive to HIV-1 infection.
Badia R, Pujantell M, Torres-Torronteras J, Menéndez-Arias L, Martí R, Ruzo A, Pauls E, Clotet B, Ballana E, Esté JA, Riveira-Muñoz E
Antiviral research 2017 Jun;142:123-135
Antiviral research 2017 Jun;142:123-135
Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
Riess M, Fuchs NV, Idica A, Hamdorf M, Flory E, Pedersen IM, König R
The Journal of biological chemistry 2017 Jan 6;292(1):264-277
The Journal of biological chemistry 2017 Jan 6;292(1):264-277
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Herold N, Rudd SG, Ljungblad L, Sanjiv K, Myrberg IH, Paulin CB, Heshmati Y, Hagenkort A, Kutzner J, Page BD, Calderón-Montaño JM, Loseva O, Jemth AS, Bulli L, Axelsson H, Tesi B, Valerie NC, Höglund A, Bladh J, Wiita E, Sundin M, Uhlin M, Rassidakis G, Heyman M, Tamm KP, Warpman-Berglund U, Walfridsson J, Lehmann S, Grandér D, Lundbäck T, Kogner P, Henter JI, Helleday T, Schaller T
Nature medicine 2017 Feb;23(2):256-263
Nature medicine 2017 Feb;23(2):256-263
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Schneider C, Oellerich T, Baldauf HM, Schwarz SM, Thomas D, Flick R, Bohnenberger H, Kaderali L, Stegmann L, Cremer A, Martin M, Lohmeyer J, Michaelis M, Hornung V, Schliemann C, Berdel WE, Hartmann W, Wardelmann E, Comoglio F, Hansmann ML, Yakunin AF, Geisslinger G, Ströbel P, Ferreirós N, Serve H, Keppler OT, Cinatl J Jr
Nature medicine 2017 Feb;23(2):250-255
Nature medicine 2017 Feb;23(2):250-255
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Sommer AF, Rivière L, Qu B, Schott K, Riess M, Ni Y, Shepard C, Schnellbächer E, Finkernagel M, Himmelsbach K, Welzel K, Kettern N, Donnerhak C, Münk C, Flory E, Liese J, Kim B, Urban S, König R
Scientific reports 2016 May 27;6:26616
Scientific reports 2016 May 27;6:26616
Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection.
Fu W, Qiu C, Zhou M, Zhu L, Yang Y, Qiu C, Zhang L, Xu X, Wang Y, Xu J, Zhang X
Scientific reports 2016 Dec 6;6:38162
Scientific reports 2016 Dec 6;6:38162
Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells.
Witkowski W, Vermeire J, Landi A, Naessens E, Vanderstraeten H, Nauwynck H, Favoreel H, Verhasselt B
PloS one 2015;10(7):e0133651
PloS one 2015;10(7):e0133651
Interferon-stimulated gene factor 3 complex is required for the induction of sterile α motif and HD domain-containing protein 1 expression by interferon-α in SMMC-7721 cells.
Zhu M, Lu J, Dong X, Zheng N, Li T, Chen Z, Pan X, Zhu Y, Yan H, Shen Y, Ying S, Hu C
Molecular medicine reports 2015 Nov;12(5):7176-80
Molecular medicine reports 2015 Nov;12(5):7176-80
Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans.
de Castro-Amarante MF, Pise-Masison CA, McKinnon K, Washington Parks R, Galli V, Omsland M, Andresen V, Massoud R, Brunetto G, Caruso B, Venzon D, Jacobson S, Franchini G
Journal of virology 2015 Nov 25;90(5):2195-207
Journal of virology 2015 Nov 25;90(5):2195-207
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
Shingai M, Welbourn S, Brenchley JM, Acharya P, Miyagi E, Plishka RJ, Buckler-White A, Kwong PD, Nishimura Y, Strebel K, Martin MA
PLoS pathogens 2015 May;11(5):e1004928
PLoS pathogens 2015 May;11(5):e1004928
SAMHD1 prevents autoimmunity by maintaining genome stability.
Kretschmer S, Wolf C, König N, Staroske W, Guck J, Häusler M, Luksch H, Nguyen LA, Kim B, Alexopoulou D, Dahl A, Rapp A, Cardoso MC, Shevchenko A, Lee-Kirsch MA
Annals of the rheumatic diseases 2015 Mar;74(3):e17
Annals of the rheumatic diseases 2015 Mar;74(3):e17
SAMHD1's protein expression profile in humans.
Schmidt S, Schenkova K, Adam T, Erikson E, Lehmann-Koch J, Sertel S, Verhasselt B, Fackler OT, Lasitschka F, Keppler OT
Journal of leukocyte biology 2015 Jul;98(1):5-14
Journal of leukocyte biology 2015 Jul;98(1):5-14
HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells.
Chauveau L, Puigdomenech I, Ayinde D, Roesch F, Porrot F, Bruni D, Visseaux B, Descamps D, Schwartz O
Retrovirology 2015 Jan 13;12:2
Retrovirology 2015 Jan 13;12:2
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity.
Pauls E, Badia R, Torres-Torronteras J, Ruiz A, Permanyer M, Riveira-Muñoz E, Clotet B, Marti R, Ballana E, Esté JA
AIDS (London, England) 2014 Sep 24;28(15):2213-22
AIDS (London, England) 2014 Sep 24;28(15):2213-22
Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells.
Calantone N, Wu F, Klase Z, Deleage C, Perkins M, Matsuda K, Thompson EA, Ortiz AM, Vinton CL, Ourmanov I, Loré K, Douek DC, Estes JD, Hirsch VM, Brenchley JM
Immunity 2014 Sep 18;41(3):493-502
Immunity 2014 Sep 18;41(3):493-502
Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.
Reinhard C, Bottinelli D, Kim B, Luban J
Retrovirology 2014 Feb 1;11:12
Retrovirology 2014 Feb 1;11:12
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.
Ballana E, Badia R, Terradas G, Torres-Torronteras J, Ruiz A, Pauls E, Riveira-Muñoz E, Clotet B, Martí R, Esté JA
Antimicrobial agents and chemotherapy 2014 Aug;58(8):4804-13
Antimicrobial agents and chemotherapy 2014 Aug;58(8):4804-13
Inhibition of Hepatitis B virus replication by SAMHD1.
Chen Z, Zhu M, Pan X, Zhu Y, Yan H, Jiang T, Shen Y, Dong X, Zheng N, Lu J, Ying S, Shen Y
Biochemical and biophysical research communications 2014 Aug 8;450(4):1462-8
Biochemical and biophysical research communications 2014 Aug 8;450(4):1462-8
SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells.
Puigdomènech I, Casartelli N, Porrot F, Schwartz O
Journal of virology 2013 Mar;87(5):2846-56
Journal of virology 2013 Mar;87(5):2846-56
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT
Nature medicine 2012 Nov;18(11):1682-7
Nature medicine 2012 Nov;18(11):1682-7
Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells.
Zhou T, Dang Y, Baker JJ, Zhou J, Zheng YH
Retrovirology 2012 Nov 7;9:93
Retrovirology 2012 Nov 7;9:93
Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression.
Thiele H, du Moulin M, Barczyk K, George C, Schwindt W, Nürnberg G, Frosch M, Kurlemann G, Roth J, Nürnberg P, Rutsch F
Human mutation 2010 Nov;31(11):E1836-50
Human mutation 2010 Nov;31(11):E1836-50
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response.
Rice GI, Bond J, Asipu A, Brunette RL, Manfield IW, Carr IM, Fuller JC, Jackson RM, Lamb T, Briggs TA, Ali M, Gornall H, Couthard LR, Aeby A, Attard-Montalto SP, Bertini E, Bodemer C, Brockmann K, Brueton LA, Corry PC, Desguerre I, Fazzi E, Cazorla AG, Gener B, Hamel BC, Heiberg A, Hunter M, van der Knaap MS, Kumar R, Lagae L, Landrieu PG, Lourenco CM, Marom D, McDermott MF, van der Merwe W, Orcesi S, Prendiville JS, Rasmussen M, Shalev SA, Soler DM, Shinawi M, Spiegel R, Tan TY, Vanderver A, Wakeling EL, Wassmer E, Whittaker E, Lebon P, Stetson DB, Bonthron DT, Crow YJ
Nature genetics 2009 Jul;41(7):829-32
Nature genetics 2009 Jul;41(7):829-32
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 12586-1-AP(SAMHD1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-SAMHD1 (IP:12586-1-AP, 3ug; Detection:12586-1-AP 1:300) with K-562 cells lysate 2400ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SAMHD1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SAMHD1. This antibody recognizes human, mouse, rat antigen. The SAMHD1 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.