CDH4

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Description

Cadherin 4

Tissue specificity

Tissue enhanced (brain, lymphoid tissue, ovary, skeletal muscle)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

20 (61252261 - 61940617)

Ensembl ID

ENSG00000179242  (ver. 103.38)

Orthologs

Mouse Cdh4: ENSMUSG00000000305

UniProt

P55283

neXtProt

NX_P55283

Human splice variants
Mouse splice variants

Protein structure