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- References [32]
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- Immunohistochemistry [1]
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- Product number
- 11661-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11661-1-AP, RRID:AB_2180392
- Product name
- RRM2 antibody
- Antibody type
- Polyclonal
- Description
- RRM2 antibody (Cat. #11661-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrative metabolomic and single-cell transcriptomic analysis of recurrent condyloma acuminatum in humans.
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
Erianin facilitates pyroptosis in endometrial cancer via targeting m6A reader YTHDF1.
Cyclin Y interacts with Chk1 to activate RRM2/STAT3 signaling and promotes radioresistance in non-small cell lung cancer.
CYB5R4 sustains endothelial proliferation and ischemia-induced angiogenesis by maintaining RRM2-dependent nucleotide balance.
M6A modification of RRM2 drives B cell hyperactivity in primary Sjögren's syndrome.
FOXM1-activated IGF2BP3 promotes cell malignant phenotypes and M2 macrophage polarization in hepatocellular carcinoma by inhibiting ferroptosis via stabilizing RRM2 mRNA in an m6A-dependent manner.
SSBP1 positively regulates RRM2, affecting epithelial mesenchymal transition and cell cycle arrest in human lung adenocarcinoma cells.
Using Multiomics and Machine Learning: Insights into Improving the Outcomes of Clear Cell Renal Cell Carcinoma via the SRD5A3-AS1/hsa-let-7e-5p/RRM2 Axis.
Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells.
Integration of scRNA-seq and ST-seq identifies hyperproliferative RRM2+ cells features and therapeutic targets in gastric cancer.
KAT7-acetylated YBX1 promotes hepatocellular carcinoma proliferation by reprogramming nucleotide metabolism.
IKBKE regulates renal cell carcinoma progression and sunitinib resistance through the RRM2-AKT pathway.
The potential of ribonucleotide reductase M2 as a novel prognostic maker and therapeutic target to inhibit medulloblastoma proliferation, migration, and invasiveness.
RRM2 promotes liver metastasis of pancreatic cancer by stabilizing YBX1 and activating the TGF-beta pathway.
RRM2 promotes the proliferation of chicken myoblasts, inhibits their differentiation and muscle regeneration.
The mechano-chemical circuit in fibroblasts and dendritic cells drives basal cell proliferation in psoriasis.
Machine learning reveals diverse cell death patterns in lung adenocarcinoma prognosis and therapy.
RRM2‑mediated Wnt/β‑catenin signaling pathway activation in lung adenocarcinoma: A potential prognostic biomarker.
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYC.
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.
Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.
Integrated multi-omics approach revealed cellular senescence landscape.
Breaking the Iron Homeostasis: A "Trojan Horse" Self-Assembled Nanodrug Sensitizes Homologous Recombination Proficient Ovarian Cancer Cells to PARP Inhibition.
A Novel Ferroptosis-Based Molecular Signature Associated with Biochemical Recurrence-Free Survival and Tumor Immune Microenvironment of Prostate Cancer.
The High Expression of RRM2 Can Predict the Malignant Transformation of Endometriosis.
A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma.
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Potential tumor‑suppressive role of microRNA‑99a‑3p in sunitinib‑resistant renal cell carcinoma cells through the regulation of RRM2.
Inhibition of HIV early replication by the p53 and its downstream gene p21.
Long-term HIV-1 infection induces an antiviral state in primary macrophages.
Wei Y, Xu Y, Feng C, Chen S, Chen J, Wang J, Pan J, Song Y, Hua C, Cai M, Cheng H, Zhu J
Scientific reports 2026 Feb 4;16(1)
Scientific reports 2026 Feb 4;16(1)
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
Ren J, Wu S, Su T, Li H, Ding J, Chen F, Mo J, Li J, Wang Z, Han L, Wu Z
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
Erianin facilitates pyroptosis in endometrial cancer via targeting m6A reader YTHDF1.
Shu W, Zhou X, Zhao R, Dong K, Shen X, Chen G, Cheng S, Zhang Q, Zhou T, Zhang J, Zhang T, Yu S, Li H, Yao Y, Liu Y, Zhang J, Wang H
Chinese medicine 2026 Apr 7;21(1)
Chinese medicine 2026 Apr 7;21(1)
Cyclin Y interacts with Chk1 to activate RRM2/STAT3 signaling and promotes radioresistance in non-small cell lung cancer.
Liu Z, Xue H, Wang Z, Zhao Y, Xu S, Dong X
International journal of biological sciences 2025;21(5):1999-2011
International journal of biological sciences 2025;21(5):1999-2011
CYB5R4 sustains endothelial proliferation and ischemia-induced angiogenesis by maintaining RRM2-dependent nucleotide balance.
Yuan S, Hahn SA, Colussi NC, Mullett SJ, Gelhaus SL, Schopfer FJ, Straub AC
bioRxiv : the preprint server for biology 2025 Sep 20;
bioRxiv : the preprint server for biology 2025 Sep 20;
M6A modification of RRM2 drives B cell hyperactivity in primary Sjögren's syndrome.
Yang Y, Liu K, Zhang H, Li Y, Guo M
Life sciences 2025 Oct 15;379:123884
Life sciences 2025 Oct 15;379:123884
FOXM1-activated IGF2BP3 promotes cell malignant phenotypes and M2 macrophage polarization in hepatocellular carcinoma by inhibiting ferroptosis via stabilizing RRM2 mRNA in an m6A-dependent manner.
Gao H, Shi L, Liu J, Zhao Y, Du F, He Y, Yang X, Song N, Wen J, Zheng G
Molecular and cellular biochemistry 2025 May;480(5):3051-3066
Molecular and cellular biochemistry 2025 May;480(5):3051-3066
SSBP1 positively regulates RRM2, affecting epithelial mesenchymal transition and cell cycle arrest in human lung adenocarcinoma cells.
Yang X, Ma B, Liu Y, Zhou J, Guo J, Peng Y, Bai Y, Wu J, Hu D
Cellular signalling 2025 Mar;127:111552
Cellular signalling 2025 Mar;127:111552
Using Multiomics and Machine Learning: Insights into Improving the Outcomes of Clear Cell Renal Cell Carcinoma via the SRD5A3-AS1/hsa-let-7e-5p/RRM2 Axis.
Sun M, Yang Z, Luo Y, Qin L, Peng L, Pan C, Yan J, Qiu T, Zhang Y
ACS omega 2025 Jun 24;10(24):25633-25647
ACS omega 2025 Jun 24;10(24):25633-25647
Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells.
Koppenhafer SL, Geary EL, Thomas MV, Croushore EE, Zimmerman JAO, Gedminas JM, Quelle DE, Dodd RD, Gordon DJ
Cancer research communications 2025 Jun 1;5(6):1034-1048
Cancer research communications 2025 Jun 1;5(6):1034-1048
Integration of scRNA-seq and ST-seq identifies hyperproliferative RRM2+ cells features and therapeutic targets in gastric cancer.
Ping S, Jia X, Tian Y
Journal of translational medicine 2025 Jul 15;23(1):795
Journal of translational medicine 2025 Jul 15;23(1):795
KAT7-acetylated YBX1 promotes hepatocellular carcinoma proliferation by reprogramming nucleotide metabolism.
Huang H, Ren L, Zhou Y, Chen P, Zhao H, Li S, Wang H, Li X
BMC cancer 2025 Feb 21;25(1):311
BMC cancer 2025 Feb 21;25(1):311
IKBKE regulates renal cell carcinoma progression and sunitinib resistance through the RRM2-AKT pathway.
Liu S, Li J, Zhang J, Wan F, Hong Z, Hong Z, Dai B
International journal of biological sciences 2024;20(15):6146-6161
International journal of biological sciences 2024;20(15):6146-6161
The potential of ribonucleotide reductase M2 as a novel prognostic maker and therapeutic target to inhibit medulloblastoma proliferation, migration, and invasiveness.
Wu X, Gou P, Fang C, Zhou Y, Li L, Zhai X, Liang P
Pediatric discovery 2024 Sep;2(3):e81
Pediatric discovery 2024 Sep;2(3):e81
RRM2 promotes liver metastasis of pancreatic cancer by stabilizing YBX1 and activating the TGF-beta pathway.
Du Z, Zhang Q, Xiang X, Li W, Yang Q, Yu H, Liu T
iScience 2024 Oct 18;27(10):110864
iScience 2024 Oct 18;27(10):110864
RRM2 promotes the proliferation of chicken myoblasts, inhibits their differentiation and muscle regeneration.
Chen B, Zhang Y, Niu Y, Wang Y, Liu Y, Ji H, Han R, Tian Y, Liu X, Kang X, Li Z
Poultry science 2024 Mar;103(3):103407
Poultry science 2024 Mar;103(3):103407
The mechano-chemical circuit in fibroblasts and dendritic cells drives basal cell proliferation in psoriasis.
Jiang J, Shao X, Liu W, Wang M, Li Q, Wang M, Xiao Y, Li K, Liang H, Wang N, Xu X, Wu Y, Gao X, Xie Q, Xiang X, Liu W, Wu W, Yang L, Gu ZZ, Chen J, Lei M
Cell reports 2024 Jul 23;43(7):114513
Cell reports 2024 Jul 23;43(7):114513
Machine learning reveals diverse cell death patterns in lung adenocarcinoma prognosis and therapy.
Wang S, Wang R, Hu D, Zhang C, Cao P, Huang J
NPJ precision oncology 2024 Feb 26;8(1):49
NPJ precision oncology 2024 Feb 26;8(1):49
RRM2‑mediated Wnt/β‑catenin signaling pathway activation in lung adenocarcinoma: A potential prognostic biomarker.
Jiang Y, Hu X, Pang M, Huang Y, Ren B, He L, Jiang L
Oncology letters 2023 Oct;26(4):417
Oncology letters 2023 Oct;26(4):417
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Tan J, Wang W, Liu X, Xu J, Che Y, Liu Y, Hu J, Hu L, Li J, Zhou Q
Communications biology 2023 Jun 5;6(1):606
Communications biology 2023 Jun 5;6(1):606
miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYC.
Zhang X, Sun J, Zhang P, Wen T, Wang R, Liang L, Yang Z, Li J, Zhang J, Che B, Feng X, Liu X, Han H, Yan X
Molecular therapy. Nucleic acids 2023 Jun 13;32:343-358
Molecular therapy. Nucleic acids 2023 Jun 13;32:343-358
lncRNA IGF2-AS Regulates Nucleotide Metabolism by Mediating HMGA1 to Promote Pyroptosis of Endothelial Progenitor Cells in Sepsis Patients.
Liang G, Zeng M, Gao M, Xing W, Jin X, Wang Q, Deng L, Ou H, He Z
Oxidative medicine and cellular longevity 2022;2022:9369035
Oxidative medicine and cellular longevity 2022;2022:9369035
Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.
Ye T, Lin L, Cao L, Huang W, Wei S, Shan Y, Zhang Z
Frontiers in oncology 2022;12:863266
Frontiers in oncology 2022;12:863266
Integrated multi-omics approach revealed cellular senescence landscape.
Song Q, Hou Y, Zhang Y, Liu J, Wang Y, Fu J, Zhang C, Cao M, Cui Y, Zhang X, Wang X, Zhang J, Liu C, Zhang Y, Wang P
Nucleic acids research 2022 Oct 28;50(19):10947-10963
Nucleic acids research 2022 Oct 28;50(19):10947-10963
Breaking the Iron Homeostasis: A "Trojan Horse" Self-Assembled Nanodrug Sensitizes Homologous Recombination Proficient Ovarian Cancer Cells to PARP Inhibition.
Li Y, Cen Y, Fang Y, Tang S, Li S, Ren Y, Zhang H, Lu W, Xu J
ACS nano 2022 Aug 23;16(8):12786-12800
ACS nano 2022 Aug 23;16(8):12786-12800
A Novel Ferroptosis-Based Molecular Signature Associated with Biochemical Recurrence-Free Survival and Tumor Immune Microenvironment of Prostate Cancer.
Ke ZB, You Q, Sun JB, Zhu JM, Li XD, Chen DN, Su L, Zheng QS, Wei Y, Xue XY, Xu N
Frontiers in cell and developmental biology 2021;9:774625
Frontiers in cell and developmental biology 2021;9:774625
The High Expression of RRM2 Can Predict the Malignant Transformation of Endometriosis.
Yang B, Wang T, Li N, Zhang W, Hu Y
Advances in therapy 2021 Oct;38(10):5178-5190
Advances in therapy 2021 Oct;38(10):5178-5190
A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma.
Shen H, Wu H, Sun F, Qi J, Zhu Q
Bioengineered 2021 Dec;12(1):240-251
Bioengineered 2021 Dec;12(1):240-251
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Wu Z, Zhan Y, Wang L, Tong J, Zhang L, Lin M, Jin X, Jiang L, Lou Y, Qiu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Potential tumor‑suppressive role of microRNA‑99a‑3p in sunitinib‑resistant renal cell carcinoma cells through the regulation of RRM2.
Osako Y, Yoshino H, Sakaguchi T, Sugita S, Yonemori M, Nakagawa M, Enokida H
International journal of oncology 2019 May;54(5):1759-1770
International journal of oncology 2019 May;54(5):1759-1770
Inhibition of HIV early replication by the p53 and its downstream gene p21.
Shi B, Sharifi HJ, DiGrigoli S, Kinnetz M, Mellon K, Hu W, de Noronha CMC
Virology journal 2018 Mar 27;15(1):53
Virology journal 2018 Mar 27;15(1):53
Long-term HIV-1 infection induces an antiviral state in primary macrophages.
Pujantell M, Badia R, Ramirez C, Puig T, Clotet B, Ballana E, Esté JA, Riveira-Muñoz E
Antiviral research 2016 Sep;133:145-55
Antiviral research 2016 Sep;133:145-55
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 11661-1-AP(RRM2 antibody) at dilution of 1:200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RRM2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RRM2. This antibody recognizes human,mouse,rat antigen. The RRM2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
