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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 18042-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18042-1-AP, RRID:AB_2074004
- Product name
- CCNY antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CCNY antibody (Cat. #18042-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Myristoylation-dependent palmitoylation of cyclin Y modulates long-term potentiation and spatial learning.
The Candidate IBD Risk Gene CCNY Is Dispensable for Intestinal Epithelial Homeostasis.
Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway.
Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.
Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex.
Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons.
Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.
Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.
Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.
Seo J, Hwang H, Choi Y, Jung S, Hong JH, Yoon BJ, Rhim H, Park M
Progress in neurobiology 2022 Nov;218:102349
Progress in neurobiology 2022 Nov;218:102349
The Candidate IBD Risk Gene CCNY Is Dispensable for Intestinal Epithelial Homeostasis.
Molinas A, Heil S, Koch S
Cells 2021 Sep 6;10(9)
Cells 2021 Sep 6;10(9)
Cyclin Y, a novel actin-binding protein, regulates spine plasticity through the cofilin-actin pathway.
Hwang H, Hur YN, Sohn H, Seo J, Hong JH, Cho E, Choi Y, Lee S, Song S, Lee AR, Kim S, Jo DG, Rhim H, Park M
Progress in neurobiology 2021 Mar;198:101915
Progress in neurobiology 2021 Mar;198:101915
Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
Hwang H, Seo J, Choi Y, Cho E, Sohn H, Jang J, Lee AR, Lee J, Kim S, Koh HY, Park M
Pharmacological research 2020 Oct;160:105100
Pharmacological research 2020 Oct;160:105100
Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.
Chen L, Wang X, Cheng H, Zhang W, Liu Y, Zeng W, Yu L, Huang C, Liu G
Biochemical and biophysical research communications 2020 Dec 17;533(4):1162-1169
Biochemical and biophysical research communications 2020 Dec 17;533(4):1162-1169
Phosphoregulation of the oncogenic protein regulator of cytokinesis 1 (PRC1) by the atypical CDK16/CCNY complex.
Hernández-Ortega S, Sánchez-Botet A, Quandt E, Masip N, Gasa L, Verde G, Jiménez J, Levin RS, Rutaganira FU, Burlingame AL, Wolfgeher D, Ribeiro MPC, Kron SJ, Shokat KM, Clotet J
Experimental & molecular medicine 2019 Apr 16;51(4):1-17
Experimental & molecular medicine 2019 Apr 16;51(4):1-17
Cyclin Y-mediated transcript profiling reveals several important functional pathways regulated by Cyclin Y in hippocampal neurons.
Joe IS, Kim JH, Kim H, Hong JH, Kim M, Park M
PloS one 2017;12(2):e0172547
PloS one 2017;12(2):e0172547
Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.
Wang X, Jia Y, Fei C, Song X, Li L
The Journal of biological chemistry 2016 Dec 16;291(51):26427-26434
The Journal of biological chemistry 2016 Dec 16;291(51):26427-26434
Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP.
Cho E, Kim DH, Hur YN, Whitcomb DJ, Regan P, Hong JH, Kim H, Ho Suh Y, Cho K, Park M
Scientific reports 2015 Jul 29;5:12624
Scientific reports 2015 Jul 29;5:12624
Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16.
Shehata SN, Deak M, Morrice NA, Ohta E, Hunter RW, Kalscheuer VM, Sakamoto K
The Biochemical journal 2015 Aug 1;469(3):409-20
The Biochemical journal 2015 Aug 1;469(3):409-20
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.
Shehata SN, Hunter RW, Ohta E, Peggie MW, Lou HJ, Sicheri F, Zeqiraj E, Turk BE, Sakamoto K
Cellular signalling 2012 Nov;24(11):2085-94
Cellular signalling 2012 Nov;24(11):2085-94
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 18042-1-AP(CCNY antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using CCNY antibody 18042-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CCNY (IP:18042-1-AP, 3ug; Detection:18042-1-AP 1:600) with K-562 cells lysate 2400ug.
- Sample type
- cell line
