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- Antigen structure
- References [9]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11127-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11127-2-AP, RRID:AB_2189373
- Product name
- SH3BP5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SH3BP5 antibody (Cat. #11127-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Single-Cell and Multiomic Analysis Reveals Neutrophil Heterogeneity and Prognostic Value in Cervical Lesions.
The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice.
Jiangzhi Granule Ameliorates JNK-Mediated Mitochondrial Dysfunction to Reduce Lipotoxic Liver Injury in NASH.
Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway.
Scoparone Improves Nonalcoholic Steatohepatitis Through Alleviating JNK/Sab Signaling Pathway-Mediated Mitochondrial Dysfunction.
Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells.
Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury.
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.
Wang Z, Zhuang L, Liu S, Cao C, Chen S, Yu N, Huang X, Zhang T
Cancer science 2026 Mar;117(3):597-612
Cancer science 2026 Mar;117(3):597-612
The Effective Compound Combination of Bufei Yishen Formula III Improves the Mitochondrial Dysfunction via Inhibiting JNK/Sab Pathway in COPD Mice.
Song M, Han M, Zhang H, Yang Y, Tian Y, Li J, Zhao J
Drug design, development and therapy 2025;19:525-538
Drug design, development and therapy 2025;19:525-538
Jiangzhi Granule Ameliorates JNK-Mediated Mitochondrial Dysfunction to Reduce Lipotoxic Liver Injury in NASH.
Jiang Y, Xu J, Ding J, Liu T, Liu Y, Huang P, Wang Q, Zheng P, Song H, Yang L
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:23-36
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:23-36
Fluorofenidone protects against acute liver failure in mice by regulating MKK4/JNK pathway.
Gu L, He X, Zhang Y, Li S, Tang J, Ma R, Yang X, Huang H, Peng Y, Xie Y, Peng Z, Meng J, Hu G, Tao L, Liu X, Yang H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114844
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114844
Scoparone Improves Nonalcoholic Steatohepatitis Through Alleviating JNK/Sab Signaling Pathway-Mediated Mitochondrial Dysfunction.
Jiang Y, Xu J, Huang P, Yang L, Liu Y, Li Y, Wang J, Song H, Zheng P
Frontiers in pharmacology 2022;13:863756
Frontiers in pharmacology 2022;13:863756
Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells.
Li M, Hao S, Li C, Xiao H, Sun L, Yu Z, Zhang N, Xiong Y, Zhao D, Yin Y
Biomolecules 2019 Sep 19;9(9)
Biomolecules 2019 Sep 19;9(9)
Liver-specific deficiency of unc-51 like kinase 1 and 2 protects mice from acetaminophen-induced liver injury.
Sun Y, Li TY, Song L, Zhang C, Li J, Lin ZZ, Lin SC, Lin SY
Hepatology (Baltimore, Md.) 2018 Jun;67(6):2397-2413
Hepatology (Baltimore, Md.) 2018 Jun;67(6):2397-2413
Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity.
Win S, Than TA, Le BH, García-Ruiz C, Fernandez-Checa JC, Kaplowitz N
Journal of hepatology 2015 Jun;62(6):1367-74
Journal of hepatology 2015 Jun;62(6):1367-74
JNK interaction with Sab mediates ER stress induced inhibition of mitochondrial respiration and cell death.
Win S, Than TA, Fernandez-Checa JC, Kaplowitz N
Cell death & disease 2014 Jan 9;5(1):e989
Cell death & disease 2014 Jan 9;5(1):e989
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Raji cells were subjected to SDS PAGE followed by western blot with 11127-2-AP(SH3BP5 antibody) at dilution of 1:200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SH3BP5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SH3BP5. This antibody recognizes human,mouse,rat antigen. The SH3BP5 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
