Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 12766-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12766-1-AP, RRID:AB_10596774
- Product name
- BBS4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BBS4 antibody (Cat. #12766-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase.
An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis.
Phosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis.
The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis.
The mechanism of acentrosomal spindle assembly in human oocytes.
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base.
Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.
Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.
Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.
Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.
Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.
BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1.
BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors.
Zhang T, Zhao F, Li J, Sun X, Zhang X, Wang H, Fan P, Lai L, Li Z, Sui T
Nucleic acids research 2024 Apr 12;52(6):2776-2791
Nucleic acids research 2024 Apr 12;52(6):2776-2791
An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis.
Cao M, Zou X, Li C, Lin Z, Wang N, Zou Z, Ye Y, Seemann J, Levine B, Tang Z, Zhong Q
Nature communications 2023 Mar 27;14(1):1687
Nature communications 2023 Mar 27;14(1):1687
Phosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis.
Zhang L, Zhang H, Agborbesong E, Zhou JX, Li X
Cell death & disease 2023 Dec 5;14(12):795
Cell death & disease 2023 Dec 5;14(12):795
The centrosomal protein 131 participates in the regulation of mitochondrial apoptosis.
Renaud CCN, Trillet K, Jardine J, Merlet L, Renoult O, Laurent-Blond M, Catinaud Z, Pecqueur C, Gavard J, Bidère N
Communications biology 2023 Dec 15;6(1):1271
Communications biology 2023 Dec 15;6(1):1271
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base.
Jang DG, Kwon KY, Kweon YC, Kim BG, Myung K, Lee HS, Young Park C, Kwon T, Park TJ
eLife 2022 Aug 25;11
eLife 2022 Aug 25;11
Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.
Arslanhan MD, Rauniyar N, Yates JR 3rd, Firat-Karalar EN
EMBO reports 2021 Aug 4;22(8):e51902
EMBO reports 2021 Aug 4;22(8):e51902
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.
Zhang Y, Hao J, Tarrago MG, Warner GM, Giorgadze N, Wei Q, Huang Y, He K, Chen C, Peclat TR, White TA, Ling K, Tchkonia T, Kirkland JL, Chini EN, Hu J
Cell reports 2021 Aug 3;36(5):109481
Cell reports 2021 Aug 3;36(5):109481
Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.
Xiong Y, Scerbo MJ, Seelig A, Volta F, O'Brien N, Dicker A, Padula D, Lickert H, Gerdes JM, Berggren PO
eLife 2020 Nov 17;9
eLife 2020 Nov 17;9
Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.
Haq N, Schmidt-Hieber C, Sialana FJ, Ciani L, Heller JP, Stewart M, Bentley L, Wells S, Rodenburg RJ, Nolan PM, Forsythe E, Wu MC, Lubec G, Salinas P, Häusser M, Beales PL, Christou-Savina S
PLoS biology 2019 Sep;17(9):e3000414
PLoS biology 2019 Sep;17(9):e3000414
Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.
Conkar D, Bayraktar H, Firat-Karalar EN
Scientific reports 2019 Oct 3;9(1):14250
Scientific reports 2019 Oct 3;9(1):14250
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
Odabasi E, Gul S, Kavakli IH, Firat-Karalar EN
EMBO reports 2019 Jun;20(6)
EMBO reports 2019 Jun;20(6)
The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.
Struchtrup A, Wiegering A, Stork B, Rüther U, Gerhardt C
Autophagy 2018;14(4):567-583
Autophagy 2018;14(4):567-583
Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.
Krastev DB, Pettitt SJ, Campbell J, Song F, Tanos BE, Stoynov SS, Ashworth A, Lord CJ
Nature communications 2018 May 22;9(1):2016
Nature communications 2018 May 22;9(1):2016
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Kanie T, Abbott KL, Mooney NA, Plowey ED, Demeter J, Jackson PK
Developmental cell 2017 Jul 10;42(1):22-36.e12
Developmental cell 2017 Jul 10;42(1):22-36.e12
DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.
Zhang B, Wang G, Xu X, Yang S, Zhuang T, Wang G, Ren H, Cheng SY, Jiang Q, Zhang C
The Journal of biological chemistry 2017 Jan 27;292(4):1351-1360
The Journal of biological chemistry 2017 Jan 27;292(4):1351-1360
BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1.
Prieto-Echagüe V, Lodh S, Colman L, Bobba N, Santos L, Katsanis N, Escande C, Zaghloul NA, Badano JL
Scientific reports 2017 Aug 29;7(1):9765
Scientific reports 2017 Aug 29;7(1):9765
BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors.
Xu Q, Zhang Y, Wei Q, Huang Y, Li Y, Ling K, Hu J
Scientific reports 2015 Jul 7;5:11855
Scientific reports 2015 Jul 7;5:11855
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12766-1-AP(BBS4 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 12766-1-AP(BBS4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 12766-1-AP(BBS4 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue