66618-2-Ig

antibody from Proteintech Group

Targeting: SPI1 OF, PU.1, SFPI1, SPI-1, SPI-A

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66618-2-Ig

Provider

Proteintech Group

Product name

SPI1 antibody

Antibody type

Monoclonal

Description

SPI1 antibody (Cat. #66618-2-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2H3D3

Vial size

20ul, 150ul

References

Submitted references

Targeting injury-triggered grancalcin from senescent macrophages enhances aged bone healing.

Dong Y, Shen X, Zhuang Q, Jin S, Song Z, Ling Z, Jiang H
Acta biomaterialia 2026 Mar;212:562-578

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SPI1 mediates CST2 transcription to promote the proliferation, metastasis, and angiogenesis of esophageal cancer.

Chen F, Yu L, Wang D, Zhao Y, Li C
Archives of biochemistry and biophysics 2026 Jul;781:110832

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INHBA, transcriptionally activated by SPI1, facilitates gastric cancer progression by inducing macrophage recruitment and M2 polarization via activating the TGF-β signaling to increase CCL2.

Zhang F, Zhou C, Wang X, Liu Y, Hou Y, Niu L
Pathology, research and practice 2025 May;269:155920

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Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.

Zhong S, Su W, Wang Y, Liu D, Li X, Ma F, Xu L, Gao J, Wang H, Sun J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766

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Folate-modified biomimetic nanovesicles loaded with a PU.1 inhibitor alleviate atherosclerosis by suppressing inflammation.

Yan L, Hu X, He J, Gan H, Shi Y, Li L, Li S, Wei K, Wei J, Cai J, Li B, Pang P
Journal of nanobiotechnology 2025 Dec 5;24(1):29

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PU.1/Spi1 exacerbates ischemia-reperfusion induced acute kidney injury via upregulating Gata2 and promoting fibroblast activation.

Zong C, Xu GL, Ning M, Li JY, Wang X, Guo HJ, Zhang LH, Zhou L, Xu C, Yang ZH, Lu LM, Niu JY
Acta pharmacologica Sinica 2025 Aug;46(8):2251-2266

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SPI1(+)CD68(+) macrophages as a biomarker for gastric cancer metastasis: a rationale for combined antiangiogenic and immunotherapy strategies.

Deng G, Wang P, Su R, Sun X, Wu Z, Huang Z, Gu L, Yu H, Zhao Z, He Y, Huo M, Zhang C, Yin S
Journal for immunotherapy of cancer 2024 Oct 24;12(10)

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Exploring the Role of Neutrophil-Related Genes in Osteosarcoma via an Integrative Analysis of Single-Cell and Bulk Transcriptome.

Lu J, Rui J, Xu XY, Shen JK
Biomedicines 2024 Jul 8;12(7)

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IRF1 suppresses colon cancer proliferation by reducing SPI1-mediated transcriptional activation of GPX4 and promoting ferroptosis.

Chen Y, Lin B, Yang S, Huang J
Experimental cell research 2023 Oct 1;431(1):113733

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SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma.

Feng H, Wang T, Ye J, Yang Y, Huang X, Lai D, Lv Z, Huang Y, Zhang X
Discover oncology 2022 Dec 7;13(1):134

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ACAP1 Deficiency Predicts Inferior Immunotherapy Response in Solid Tumors.

Yi Q, Pu Y, Chao F, Bian P, Lv L
Cancers 2022 Dec 1;14(23)