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- Antigen structure
- References [29]
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- Product number
- 21166-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- MKL1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MKL1 antibody (Cat. #21166-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Human umbilical cord/placenta mesenchymal stem cell conditioned medium attenuates intestinal fibrosis in vivo and in vitro.
Role of Rho/MRTF in Aggressive Vemurafenib-Resistant Murine Melanomas and Immune Checkpoint Upregulation.
Myc-dependent dedifferentiation of Gata6(+) epidermal cells resembles reversal of terminal differentiation.
Different Mouse Models of Nemaline Myopathy Harboring Acta1 Mutations Display Differing Abnormalities Related to Mitochondrial Biology.
Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy.
The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis.
Myocardin-related transcription factor A, regulated by serum response factor, contributes to diabetic cardiomyopathy in mice.
MKL1 fuels ROS-induced proliferation of vascular smooth muscle cells by modulating FOXM1 transcription.
An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling.
Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors.
Progerin mislocalizes myocardin-related transcription factor in Hutchinson-Guilford Progeria syndrome.
Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice.
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β.
Hypoxia induces stress fiber formation in adipocytes in the early stage of obesity.
ERa-36 instead of ERa mediates the stimulatory effects of estrogen on the expression of viral oncogenes HPV E6/E7 and the malignant phenotypes in cervical cancer cells.
An MRTF-A-Sp1-PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy.
MicroRNA-143-5p modulates pulmonary artery smooth muscle cells functions in hypoxic pulmonary hypertension through targeting HIF-1α.
Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma.
MRTF-A promotes angiotensin II-induced inflammatory response and aortic dissection in mice.
Myocardin-related transcription factor A (MRTF-A) mediates doxorubicin-induced PERP transcription in colon cancer cells.
The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression.
The Wnt-β-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells.
Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells.
The Synergy of Two Factors on Insulin Expression.
MRTF-A mediates the activation of COL1A1 expression stimulated by multiple signaling pathways in human breast cancer cells.
Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells.
Transcriptional factors p300 and MRTF-A synergistically enhance the expression of migration-related genes in MCF-7 breast cancer cells.
Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells.
Choi YJ, Kim WR, Kim DH, Kim JH, Yoo JH
Stem cell research & therapy 2024 Mar 7;15(1):69
Stem cell research & therapy 2024 Mar 7;15(1):69
Role of Rho/MRTF in Aggressive Vemurafenib-Resistant Murine Melanomas and Immune Checkpoint Upregulation.
Foda BM, Neubig RR
International journal of molecular sciences 2023 Sep 7;24(18)
International journal of molecular sciences 2023 Sep 7;24(18)
Myc-dependent dedifferentiation of Gata6(+) epidermal cells resembles reversal of terminal differentiation.
Bernabé-Rubio M, Ali S, Bhosale PG, Goss G, Mobasseri SA, Tapia-Rojo R, Zhu T, Hiratsuka T, Battilocchi M, Tomás IM, Ganier C, Garcia-Manyes S, Watt FM
Nature cell biology 2023 Oct;25(10):1426-1438
Nature cell biology 2023 Oct;25(10):1426-1438
Different Mouse Models of Nemaline Myopathy Harboring Acta1 Mutations Display Differing Abnormalities Related to Mitochondrial Biology.
Tinklenberg JA, Slick RA, Sutton J, Zhang L, Meng H, Beatka MJ, Vanden Avond M, Prom MJ, Ott E, Montanaro F, Heisner J, Toro R, Hardeman EC, Geurts AM, Stowe DF, Hill RB, Lawlor MW
The American journal of pathology 2023 Oct;193(10):1548-1567
The American journal of pathology 2023 Oct;193(10):1548-1567
Aberrations in Energetic Metabolism and Stress-Related Pathways Contribute to Pathophysiology in the Neb Conditional Knockout Mouse Model of Nemaline Myopathy.
Slick RA, Tinklenberg JA, Sutton J, Zhang L, Meng H, Beatka MJ, Vanden Avond M, Prom MJ, Ott E, Montanaro F, Heisner J, Toro R, Granzier H, Geurts AM, Stowe DF, Hill RB, Lawlor MW
The American journal of pathology 2023 Oct;193(10):1528-1547
The American journal of pathology 2023 Oct;193(10):1528-1547
The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis.
Hironaka T, Takizawa N, Yamauchi Y, Horii Y, Nakaya M
The Journal of biological chemistry 2023 Mar;299(3):102934
The Journal of biological chemistry 2023 Mar;299(3):102934
Myocardin-related transcription factor A, regulated by serum response factor, contributes to diabetic cardiomyopathy in mice.
Liu L, Sun K, Luo Y, Wang B, Yang Y, Chen L, Zheng S, Wu T, Xiao P
Life sciences 2023 Mar 15;317:121470
Life sciences 2023 Mar 15;317:121470
MKL1 fuels ROS-induced proliferation of vascular smooth muscle cells by modulating FOXM1 transcription.
Wu T, Li N, Zhang Q, Liu R, Zhao H, Fan Z, Zhuo L, Yang Y, Xu Y
Redox biology 2023 Feb;59:102586
Redox biology 2023 Feb;59:102586
An injury-responsive Rac-to-Rho GTPase switch drives activation of muscle stem cells through rapid cytoskeletal remodeling.
Kann AP, Hung M, Wang W, Nguyen J, Gilbert PM, Wu Z, Krauss RS
Cell stem cell 2022 Jun 2;29(6):933-947.e6
Cell stem cell 2022 Jun 2;29(6):933-947.e6
Differential regulation of cranial and cardiac neural crest by serum response factor and its cofactors.
Dinsmore CJ, Soriano P
eLife 2022 Jan 19;11
eLife 2022 Jan 19;11
Progerin mislocalizes myocardin-related transcription factor in Hutchinson-Guilford Progeria syndrome.
von Kleeck R, Castagnino P, Assoian RK
Vascular biology (Bristol, England) 2022 Feb 1;4(1):1-10
Vascular biology (Bristol, England) 2022 Feb 1;4(1):1-10
Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice.
Huang S, Shao T, Liu H, Li T, Gui X, Zhao Q
Frontiers in cell and developmental biology 2021;9:812748
Frontiers in cell and developmental biology 2021;9:812748
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Zhang Z, Chen B, Zhu Y, Zhang T, Zhang X, Yuan Y, Xu Y
Frontiers in cell and developmental biology 2021;9:664375
Frontiers in cell and developmental biology 2021;9:664375
MRTF-A-NF-κB/p65 axis-mediated PDL1 transcription and expression contributes to immune evasion of non-small-cell lung cancer via TGF-β.
Du F, Qi X, Zhang A, Sui F, Wang X, Proud CG, Lin C, Fan X, Li J
Experimental & molecular medicine 2021 Sep;53(9):1366-1378
Experimental & molecular medicine 2021 Sep;53(9):1366-1378
Hypoxia induces stress fiber formation in adipocytes in the early stage of obesity.
Anvari G, Bellas E
Scientific reports 2021 Nov 2;11(1):21473
Scientific reports 2021 Nov 2;11(1):21473
ERa-36 instead of ERa mediates the stimulatory effects of estrogen on the expression of viral oncogenes HPV E6/E7 and the malignant phenotypes in cervical cancer cells.
Zhang X, Zhang A, Zhang X, Hu S, Bao Z, Zhang Y, Jiang X, He H, Zhang TC
Virus research 2021 Dec;306:198602
Virus research 2021 Dec;306:198602
An MRTF-A-Sp1-PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy.
Wu T, Wang H, Xin X, Yang J, Hou Y, Fang M, Lu X, Xu Y
Frontiers in cell and developmental biology 2020;8:839
Frontiers in cell and developmental biology 2020;8:839
MicroRNA-143-5p modulates pulmonary artery smooth muscle cells functions in hypoxic pulmonary hypertension through targeting HIF-1α.
Tang BI, Tang MM, Xu QM, Guo JL, Xuan L, Zhou J, Wang XJ, Zhang H, Kang PF
Journal of biosciences 2020;45
Journal of biosciences 2020;45
Rictor promotes cell migration and actin polymerization through regulating ABLIM1 phosphorylation in Hepatocellular Carcinoma.
Dong X, Feng M, Yang H, Liu H, Guo H, Gao X, Liu Y, Liu R, Zhang N, Chen R, Kong R
International journal of biological sciences 2020;16(15):2835-2852
International journal of biological sciences 2020;16(15):2835-2852
MRTF-A promotes angiotensin II-induced inflammatory response and aortic dissection in mice.
Ito S, Hashimoto Y, Majima R, Nakao E, Aoki H, Nishihara M, Ohno-Urabe S, Furusho A, Hirakata S, Nishida N, Hayashi M, Kuwahara K, Fukumoto Y
PloS one 2020;15(3):e0229888
PloS one 2020;15(3):e0229888
Myocardin-related transcription factor A (MRTF-A) mediates doxorubicin-induced PERP transcription in colon cancer cells.
Chen B, Li Z, Feng Y, Wu X, Xu Y
Biochemical and biophysical research communications 2018 Sep 10;503(3):1732-1739
Biochemical and biophysical research communications 2018 Sep 10;503(3):1732-1739
The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression.
Fernández-Barrera J, Bernabé-Rubio M, Casares-Arias J, Rangel L, Fernández-Martín L, Correas I, Alonso MA
The Journal of cell biology 2018 Mar 5;217(3):929-944
The Journal of cell biology 2018 Mar 5;217(3):929-944
The Wnt-β-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells.
He H, Du F, He Y, Wei Z, Meng C, Xu Y, Zhou H, Wang N, Luo XG, Ma W, Zhang TC
Oncotarget 2018 Mar 16;9(20):15239-15251
Oncotarget 2018 Mar 16;9(20):15239-15251
Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells.
Li Z, Chen B, Dong W, Xu W, Song M, Fang M, Guo J, Xu Y
Biochimica et biophysica acta. Gene regulatory mechanisms 2018 Jul 27;
Biochimica et biophysica acta. Gene regulatory mechanisms 2018 Jul 27;
The Synergy of Two Factors on Insulin Expression.
Luo Y, Xu Y, Wang ZY, Li X, Xing WB, Zhang TC
Cellular reprogramming 2018 Feb;20(1):49-54
Cellular reprogramming 2018 Feb;20(1):49-54
MRTF-A mediates the activation of COL1A1 expression stimulated by multiple signaling pathways in human breast cancer cells.
Meng C, He Y, Wei Z, Lu Y, Du F, Ou G, Wang N, Luo XG, Ma W, Zhang TC, He H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:718-728
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:718-728
Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells.
He H, Wei Z, Du F, Meng C, Zheng D, Lai Y, Yao H, Zhou H, Wang N, Luo XG, Ma W, Zhang TC
Cellular signalling 2017 Feb;31:87-95
Cellular signalling 2017 Feb;31:87-95
Transcriptional factors p300 and MRTF-A synergistically enhance the expression of migration-related genes in MCF-7 breast cancer cells.
He H, Wang D, Yao H, Wei Z, Lai Y, Hu J, Liu X, Wang Y, Zhou H, Wang N, Luo XG, Zhang TC
Biochemical and biophysical research communications 2015 Nov 27;467(4):813-20
Biochemical and biophysical research communications 2015 Nov 27;467(4):813-20
Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells.
Shu XZ, Zhang LN, Zhang R, Zhang CJ, He HP, Zhou H, Wang N, Zhang TC
Gene 2015 May 25;563(1):17-23
Gene 2015 May 25;563(1):17-23
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MKL1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human MKL1. This antibody recognizes human antigen. The MKL1 antibody has been validated for the following applications: ELISA, WB analysis.
