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- Antibody Data
- Antigen structure
- References [18]
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- Product number
- 22666-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- HES5 antibody
- Antibody type
- Polyclonal
- Description
- HES5 antibody (Cat. #22666-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Salidroside targets the Notch1/Hes5 axis to reconstruct the molecular innate immune-vascular network and correlates with repair after ischemic stroke.
Unveiling the neutrophil-Notch2-ISC axis: asiatic acid's therapeutic strategy in infectious colitis.
Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway.
PRMT1-catalyzed NUSAP1 methylation enhances Notch2 signaling and 5-FU resistance in gastric cancer.
Effects of Subchronic Propofol Administration on the Proliferation and Differentiation of Neural Stem Cells in Rat Hippocampus.
PRDM16 from hepatic stellate cells-derived extracellular vesicles promotes hepatocellular carcinoma progression.
Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination.
P-hydroxy benzaldehyde facilitates reprogramming of reactive astrocytes into neurons via endogenous transcriptional regulation.
Stub1 maintains proteostasis of master transcription factors in embryonic stem cells.
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.
Danzhi Xiaoyao Powder Promotes Neuronal Regeneration by Downregulating Notch Signaling Pathway in the Treatment of Generalized Anxiety Disorder.
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway.
LY411575, a potent γ-secretase inhibitor, suppresses osteoclastogenesis in vitro and LPS-induced calvarial osteolysis in vivo.
Inhibition of microRNA-34a Suppresses Epileptiform Discharges Through Regulating Notch Signaling and Apoptosis in Cultured Hippocampal Neurons.
Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway.
Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury.
Notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury.
Zeng J, Huang X, Zeng J, Huang Q, Song W, Xie Y, Liang G, Wei Q, Lan Y, Zou D, Li R, Gu L
Frontiers in immunology 2026;17:1756559
Frontiers in immunology 2026;17:1756559
Unveiling the neutrophil-Notch2-ISC axis: asiatic acid's therapeutic strategy in infectious colitis.
Zou W, Zhong M, Pei Z, Chen Y, Deng W, Li H
Frontiers in immunology 2025;16:1634063
Frontiers in immunology 2025;16:1634063
Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway.
Sun J, Lin J, Yin D, Pan Z, Ye Y, Wang Y, Wang X, Guo Q
Frontiers in pharmacology 2025;16:1572489
Frontiers in pharmacology 2025;16:1572489
PRMT1-catalyzed NUSAP1 methylation enhances Notch2 signaling and 5-FU resistance in gastric cancer.
Jiang S, Li G, Peng S, Chen S, Pang Y, Cui H, Wang F
Cell death & disease 2025 May 20;16(1):404
Cell death & disease 2025 May 20;16(1):404
Effects of Subchronic Propofol Administration on the Proliferation and Differentiation of Neural Stem Cells in Rat Hippocampus.
Chang C, Bai W, Li J, Huo S, Wang T, Shao J
Current therapeutic research, clinical and experimental 2023;98:100691
Current therapeutic research, clinical and experimental 2023;98:100691
PRDM16 from hepatic stellate cells-derived extracellular vesicles promotes hepatocellular carcinoma progression.
Sun C, Xu W, Xia Y, Wang S
American journal of cancer research 2023;13(11):5254-5270
American journal of cancer research 2023;13(11):5254-5270
Nuclear import carrier Hikeshi cooperates with HSP70 to promote murine oligodendrocyte differentiation and CNS myelination.
Li L, Li D, Sun D, Zhang X, Lei W, Wu M, Huang Q, Nian X, Dai W, Lu X, Zhou Z, Zhu Y, Xiao Y, Zhang L, Mo W, Liu Z, Zhang L
Developmental cell 2023 Nov 6;58(21):2275-2291.e6
Developmental cell 2023 Nov 6;58(21):2275-2291.e6
P-hydroxy benzaldehyde facilitates reprogramming of reactive astrocytes into neurons via endogenous transcriptional regulation.
Li X, Fan R, Xiang J, Yuan Y, Mao X, Zhou N
The International journal of neuroscience 2023 Dec;133(10):1096-1108
The International journal of neuroscience 2023 Dec;133(10):1096-1108
Stub1 maintains proteostasis of master transcription factors in embryonic stem cells.
Mamun MMA, Khan MR, Zhu Y, Zhang Y, Zhou S, Xu R, Bukhari I, Thorne RF, Li J, Zhang XD, Liu G, Chen S, Wu M, Song X
Cell reports 2022 Jun 7;39(10):110919
Cell reports 2022 Jun 7;39(10):110919
Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.
Ojha R, Tantray I, Rimal S, Mitra S, Cheshier S, Lu B
Developmental cell 2022 Jan 24;57(2):260-276.e9
Developmental cell 2022 Jan 24;57(2):260-276.e9
Danzhi Xiaoyao Powder Promotes Neuronal Regeneration by Downregulating Notch Signaling Pathway in the Treatment of Generalized Anxiety Disorder.
Liu C, Ying Z, Li Z, Zhang L, Li X, Gong W, Sun J, Fan X, Yang K, Wang X, Wei S, Dong N
Frontiers in pharmacology 2021;12:772576
Frontiers in pharmacology 2021;12:772576
hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
Wan X, Zhu L, Zhao L, Peng L, Xiong J, Yang W, Yuan J, Liang F, Zhang K, Chen K
Cell death & disease 2021 Mar 19;12(4):301
Cell death & disease 2021 Mar 19;12(4):301
Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway.
Wang Z, Nan W, Si H, Wang S, Zhang H, Li G
Life sciences 2020 Jul 1;252:117667
Life sciences 2020 Jul 1;252:117667
LY411575, a potent γ-secretase inhibitor, suppresses osteoclastogenesis in vitro and LPS-induced calvarial osteolysis in vivo.
Chen X, Chen X, Zhou Z, Qin A, Wang Y, Fan B, Xu W, Zhang S
Journal of cellular physiology 2019 Nov;234(11):20944-20956
Journal of cellular physiology 2019 Nov;234(11):20944-20956
Inhibition of microRNA-34a Suppresses Epileptiform Discharges Through Regulating Notch Signaling and Apoptosis in Cultured Hippocampal Neurons.
Wang J, Zheng Y, Cheng X, Xu F, Zhang P, Zhou X, Zhao H
Neurochemical research 2019 May;44(5):1252-1261
Neurochemical research 2019 May;44(5):1252-1261
Salidroside suppresses the metastasis of hepatocellular carcinoma cells by inhibiting the activation of the Notch1 signaling pathway.
Lu L, Liu S, Dong Q, Xin Y
Molecular medicine reports 2019 Jun;19(6):4964-4972
Molecular medicine reports 2019 Jun;19(6):4964-4972
Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury.
Zhang HM, Liu P, Jiang C, Jin XQ, Liu RN, Li SQ, Zhao Y
PloS one 2018;13(2):e0193037
PloS one 2018;13(2):e0193037
Notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating NOX2-ROS in severe traumatic brain injury.
Zhang HM, Chen W, Liu RN, Zhao Y
Drug design, development and therapy 2018;12:3847-3854
Drug design, development and therapy 2018;12:3847-3854
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HES5 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human HES5. This antibody recognizes human, mouse, rat antigen. The HES5 antibody has been validated for the following applications: ELISA, WB analysis.
