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- Antibody Data
- Antigen structure
- References [4]
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- Product number
- ABIN350362 - Provider product page
- Provider
- antibodies-online
- Proper citation
- Antibodies-Online Cat#ABIN350362, RRID:AB_10782419
- Product name
- anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide from c-terminal region of human potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (HCN4) conjugated to an immunogenic carrier protein was used as the antigen.
- Reactivity
- Human
- Host
- Sheep
- Epitope
- C-Term
- Isotype
- IgG
- Vial size
- 500 μg
- Storage
- Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
- Handling
- Avoid freeze and thaw cycles.
Submitted references Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel.
Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.
Two pacemaker channels from human heart with profoundly different activation kinetics.
Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis.
Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D
The New England journal of medicine 2006 Jan 12;354(2):151-7
The New England journal of medicine 2006 Jan 12;354(2):151-7
Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.
Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A
The Journal of biological chemistry 2004 Jun 25;279(26):27194-8
The Journal of biological chemistry 2004 Jun 25;279(26):27194-8
Two pacemaker channels from human heart with profoundly different activation kinetics.
Ludwig A, Zong X, Stieber J, Hullin R, Hofmann F, Biel M
The EMBO journal 1999 May 4;18(9):2323-9
The EMBO journal 1999 May 4;18(9):2323-9
Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis.
Seifert R, Scholten A, Gauss R, Mincheva A, Lichter P, Kaupp UB
Proceedings of the National Academy of Sciences of the United States of America 1999 Aug 3;96(16):9391-6
Proceedings of the National Academy of Sciences of the United States of America 1999 Aug 3;96(16):9391-6
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