Antibody data
- Antibody Data
- Antigen structure
- References [6]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 14147-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14147-1-AP, RRID:AB_2231876
- Product name
- FXN antibody
- Antibody type
- Polyclonal
- Description
- FXN antibody (Cat. #14147-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts.
Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia.
Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis.
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.
Autosomal recessive cerebellar ataxia caused by a homozygous mutation in PMPCA.
Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich's ataxia.
Petit F, Drecourt A, Dussiot M, Zangarelli C, Hermine O, Munnich A, Rötig A
Blood 2021 Apr 15;137(15):2090-2102
Blood 2021 Apr 15;137(15):2090-2102
Mitochondrial damage and senescence phenotype of cells derived from a novel frataxin G127V point mutation mouse model of Friedreich's ataxia.
Fil D, Chacko BK, Conley R, Ouyang X, Zhang J, Darley-Usmar VM, Zuberi AR, Lutz CM, Napierala M, Napierala JS
Disease models & mechanisms 2020 Jul 27;13(7)
Disease models & mechanisms 2020 Jul 27;13(7)
Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis.
Liu J, He H, Wang J, Guo X, Lin H, Chen H, Jiang C, Chen L, Yao P, Tang Y
Toxicology 2020 Dec 1;445:152584
Toxicology 2020 Dec 1;445:152584
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.
Télot L, Rousseau E, Lesuisse E, Garcia C, Morlet B, Léger T, Camadro JM, Serre V
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):997-1009
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):997-1009
Autosomal recessive cerebellar ataxia caused by a homozygous mutation in PMPCA.
Choquet K, Zurita-Rendón O, La Piana R, Yang S, Dicaire MJ, Care4Rare Consortium., Boycott KM, Majewski J, Shoubridge EA, Brais B, Tétreault M
Brain : a journal of neurology 2016 Mar;139(Pt 3):e19
Brain : a journal of neurology 2016 Mar;139(Pt 3):e19
Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich's ataxia.
Nabhan JF, Wood KM, Rao VP, Morin J, Bhamidipaty S, LaBranche TP, Gooch RL, Bozal F, Bulawa CE, Guild BC
Scientific reports 2016 Feb 17;6:20019
Scientific reports 2016 Feb 17;6:20019
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The FXN antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FXN. This antibody recognizes human, mouse, rat antigen. The FXN antibody has been validated for the following applications: ELISA, WB analysis.