14437-1-AP

antibody from Proteintech Group

Targeting: TMPRSS2 PRSS10

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

14437-1-AP

Provider

Proteintech Group

Product name

TMPRSS2 antibody

Antibody type

Polyclonal

Description

TMPRSS2 antibody (Cat. #14437-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Detection of SARS-CoV-2 virus in middle ear effusions and its association with otitis media with effusion.

Fu X, Wang Z, Chen B, Sun H, Lyu J, Shao J, Lu X, Xu J, Yang J, Chi F, Huang Y, Ren D
Journal of medical virology 2024 Mar;96(3):e29545

---

Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion.

Gao J, Cao C, Shi M, Hong S, Guo S, Li J, Liang T, Song P, Xu R, Li N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154942

---

Lymphocytes regulate expression of the SARS-CoV-2 cell entry factor ACE2 in the pancreas of T2DM patients.

Zhang P, Zheng CB, Liu XY, Zhang X, Huang L, Zeng X
Diabetic medicine : a journal of the British Diabetic Association 2023 Oct;40(10):e15106

---

An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity.

Wing PAC, Schmidt NM, Peters R, Erdmann M, Brown R, Wang H, Swadling L, COVIDsortium Investigators, Newman J, Thakur N, Shionoya K, Morgan SB, Hinks TS, Watashi K, Bailey D, Hansen SB, Davidson AD, Maini MK, McKeating JA
PLoS pathogens 2023 May;19(5):e1011323

---

Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2.

Cheng FJ, Ho CY, Li TS, Chen Y, Yeh YL, Wei YL, Huynh TK, Chen BR, Ko HY, Hsueh CS, Tan M, Wu YC, Huang HC, Tang CH, Chen CH, Tu CY, Huang WC
Cell & bioscience 2023 Jun 28;13(1):118

---

Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells.

Zhang J, He L, Huang R, Alvarez JF, Yang DH, Sun Q, Wang F, Peng Z, Jiang N, Su L
Molecular biology reports 2023 Jul;50(7):6039-6047

---

Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation.

Ishitoku M, Mokuda S, Araki K, Watanabe H, Kohno H, Sugimoto T, Yoshida Y, Sakaguchi T, Masumoto J, Hirata S, Sugiyama E
Viruses 2023 Jul 3;15(7)

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Growth media affects susceptibility of air-lifted human nasal epithelial cell cultures to SARS-CoV2, but not Influenza A, virus infection.

Resnick JD, Wilson JL, Anaya E, Conte A, Li M, Zhong W, Beer MA, Pekosz A
bioRxiv : the preprint server for biology 2023 Aug 2;

---

Two Resveratrol Oligomers Inhibit Cathepsin L Activity to Suppress SARS-CoV-2 Entry.

Wang C, Ye X, Ding C, Zhou M, Li W, Wang Y, You Q, Zong S, Peng Q, Duanmu D, Chen H, Sun B, Qiao J
Journal of agricultural and food chemistry 2023 Apr 12;71(14):5535-5546

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TMPRSS2 Expression and Activity Modulation by Sex-Related Hormones in Lung Calu-3 Cells: Impact on Gender-Specific SARS-CoV-2 Infection.

Treppiedi D, Marra G, Di Muro G, Catalano R, Mangili F, Esposito E, Barbieri AM, Arosio M, Mantovani G, Peverelli E
Frontiers in endocrinology 2022;13:862789

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Simvastatin Downregulates the SARS-CoV-2-Induced Inflammatory Response and Impairs Viral Infection Through Disruption of Lipid Rafts.

Teixeira L, Temerozo JR, Pereira-Dutra FS, Ferreira AC, Mattos M, Gonçalves BS, Sacramento CQ, Palhinha L, Cunha-Fernandes T, Dias SSG, Soares VC, Barreto EA, Cesar-Silva D, Fintelman-Rodrigues N, Pão CRR, de Freitas CS, Reis PA, Hottz ED, Bozza FA, Bou-Habib DC, Saraiva EM, de Almeida CJG, Viola JPB, Souza TML, Bozza PT
Frontiers in immunology 2022;13:820131

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Co-Expression and Localization of Angiotensin-Converting Enzyme-2 (ACE2) and the Transmembrane Serine Protease 2 (TMPRSS2) in Paranasal Ciliated Epithelium of Patients with Chronic Rhinosinusitis.

Kawasumi T, Takeno S, Ishino T, Ueda T, Hamamoto T, Takemoto K, Horibe Y, Takashi O
American journal of rhinology & allergy 2022 May;36(3):313-322

---

The accessible promoter-mediated supplementary effect of host factors provides new insight into the tropism of SARS-CoV-2.

Du G, Xu X, Wang J, Wang X, Ding Y, Li F, Sun Y, Tao H, Luo Y, Li H, Bo X, Chen H
Molecular therapy. Nucleic acids 2022 Jun 14;28:249-258

---

Paeniclostridium sordellii hemorrhagic toxin targets TMPRSS2 to induce colonic epithelial lesions.

Li X, He L, Luo J, Zheng Y, Zhou Y, Li D, Zhang Y, Pan Z, Li Y, Tao L
Nature communications 2022 Jul 26;13(1):4331

---

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626

---

Epipharyngeal Abrasive Therapy Down-regulates the Expression of SARS-CoV-2 Entry Factors ACE2 and TMPRSS2.

Nishi K, Yoshimoto S, Nishi S, Tsunoda T, Ohno J, Yoshimura M, Hiromatsu K, Yamano T
In vivo (Athens, Greece) 2022 Jan-Feb;36(1):371-374

---

SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway.

Willett BJ, Grove J, MacLean OA, Wilkie C, De Lorenzo G, Furnon W, Cantoni D, Scott S, Logan N, Ashraf S, Manali M, Szemiel A, Cowton V, Vink E, Harvey WT, Davis C, Asamaphan P, Smollett K, Tong L, Orton R, Hughes J, Holland P, Silva V, Pascall DJ, Puxty K, da Silva Filipe A, Yebra G, Shaaban S, Holden MTG, Pinto RM, Gunson R, Templeton K, Murcia PR, Patel AH, Klenerman P, Dunachie S, PITCH Consortium, COVID-19 Genomics UK (COG-UK) Consortium, Haughney J, Robertson DL, Palmarini M, Ray S, Thomson EC
Nature microbiology 2022 Aug;7(8):1161-1179

---

Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism.

Zhang Q, Wadgaonkar P, Xu L, Thakur C, Fu Y, Bi Z, Qiu Y, Almutairy B, Zhang W, Stemmer P, Chen F
Theranostics 2021;11(16):7970-7983

---

Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes.

Baratchian M, McManus JM, Berk MP, Nakamura F, Mukhopadhyay S, Xu W, Erzurum S, Drazba J, Peterson J, Klein EA, Gaston B, Sharifi N
Scientific reports 2021 May 27;11(1):11130

---

Distinct expression of SARS-CoV-2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps.

Wang M, Bu X, Fang G, Luan G, Huang Y, Akdis CA, Wang C, Zhang L
Allergy 2021 Mar;76(3):789-803

---

Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells.

Schweitzer KS, Crue T, Nall JM, Foster D, Sajuthi S, Correll KA, Nakamura M, Everman JL, Downey GP, Seibold MA, Bridges JP, Serban KA, Chu HW, Petrache I
The European respiratory journal 2021 Jul;58(1)

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Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System.

Zhang M, Wang P, Luo R, Wang Y, Li Z, Guo Y, Yao Y, Li M, Tao T, Chen W, Han J, Liu H, Cui K, Zhang X, Zheng Y, Qin J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Feb;8(3):2002928

---

The SARS-CoV-2 receptor, angiotensin-converting enzyme 2, is required for human endometrial stromal cell decidualization†.

Chadchan SB, Popli P, Maurya VK, Kommagani R
Biology of reproduction 2021 Feb 11;104(2):336-343

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The SARS-CoV-2 Spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease.

Avolio E, Carrabba M, Milligan R, Kavanagh Williamson M, Beltrami AP, Gupta K, Elvers KT, Gamez M, Foster RR, Gillespie K, Hamilton F, Arnold D, Berger I, Davidson AD, Hill D, Caputo M, Madeddu P
Clinical science (London, England : 1979) 2021 Dec 22;135(24):2667-2689

---

Interferon-Lambda Intranasal Protection and Differential Sex Pathology in a Murine Model of SARS-CoV-2 Infection.

Sohn SY, Hearing J, Mugavero J, Kirillov V, Gorbunova E, Helminiak L, Mishra S, Mackow E, Hearing P, Reich NC, Kim HK
mBio 2021 Dec 21;12(6):e0275621

---

Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2.

Baratchian M, McManus JM, Berk M, Nakamura F, Mukhopadhyay S, Xu W, Erzurum S, Drazba J, Peterson J, Klein EA, Gaston B, Sharifi N
bioRxiv : the preprint server for biology 2020 Oct 14;

---

Infection of human Nasal Epithelial Cells with SARS-CoV-2 and a 382-nt deletion isolate lacking ORF8 reveals similar viral kinetics and host transcriptional profiles.

Gamage AM, Tan KS, Chan WOY, Liu J, Tan CW, Ong YK, Thong M, Andiappan AK, Anderson DE, Wang Y, Wang LF
PLoS pathogens 2020 Dec;16(12):e1009130

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A cross-talk between epithelium and endothelium mediates human alveolar-capillary injury during SARS-CoV-2 infection.

Wang P, Luo R, Zhang M, Wang Y, Song T, Tao T, Li Z, Jin L, Zheng H, Chen W, Zhao M, Zheng Y, Qin J
Cell death & disease 2020 Dec 8;11(12):1042

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The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues.

Qiao J, Li W, Bao J, Peng Q, Wen D, Wang J, Sun B
Biochemical and biophysical research communications 2020 Dec 17;533(4):867-871

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The TMPRSS2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TMPRSS2. This antibody recognizes human,mouse,rat antigen. The TMPRSS2 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

14437-1-AP.pdf

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