11858-1-AP

antibody from Proteintech Group

Targeting: LGALS1 GBP

Provider product page for 11858-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [30]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 11858-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11858-1-AP, RRID:AB_2234673
Product name: Galectin-1 antibody
Antibody type: Polyclonal
Description: Galectin-1 antibody (Cat. #11858-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

LGALS1 protein structure - 11858-1-AP shown in red.

Submitted references Spatial Transcriptomics Meets Histochemistry: Insights from Glioblastoma as a Model System.

Tomioka S, Kitazawa R, Haraguchi R, Takaoka Y, Inoue A, Kitazawa S
Acta histochemica et cytochemica 2026 Feb 27;59(1):1-11

Cancer-associated fibroblasts promote immune evasion in pancreatic cancer via miR-181b-5p/STING/LGALS1 pathway.

Zhang S, Guo Y, Qi H, Wu M, Hu Y, Lv G, Ye Y, Han J, Zeng Q, Du Y, Xu B, Liu M
Cancer letters 2026 Apr 28;644:218331

Multi-omics analysis identified LGALS1 (Galectin-1) as a novel therapeutic target for clear cell renal cell carcinoma via targeting epithelial or endothelial cells.

Tan X, Chen Y, Jiang C, Shao J, Wang X
Discover oncology 2025 Oct 15;16(1):1894

Molecular landscape of atherosclerotic plaque progression: insights from proteomics, single-cell transcriptomics and genomics.

Wang C, Feng Y, Liu X, Sun H, Guo Z, Shao J, Li K, Chen J, Shu K, Kong D, Wang J, Li Y, Lei X, Li C, Liu B, Sun W, Lai Z
BMC medicine 2025 May 1;23(1):254

Impact of galectin-1's redox state on its lectin activity and monomer-dimer equilibrium. Focusing on oxidized Gal-1.

Staroňová T, Holčáková J, Voňka P, Hrstka R, Ostatná V
International journal of biological macromolecules 2025 Mar;295:139452

Galectin-1: An important regulator in myeloid differentiation and acute myeloid leukemia as well as a promising prognostic indicator and therapeutic target.

Liu L, Cheng P, Cui J, Ren S, Yao M, Li L, Zhou H, Zhang X, Qin X, Liu Y, Zhang H, Wang L, Chen M
International immunopharmacology 2025 Jun 17;158:114835

Bruceine A inhibits TGF-β1/Smad pathway in pulmonary fibrosis by blocking gal3/TGF-β1 interaction.

Du C, Ma C, Geng R, Wang X, Wang X, Yang J, Hu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156267

Galectin-1 Regulates Inflammatory Responses and Promotes Microglial M2 Polarization in Chronic Migraine.

Xiao Y, Han W, Yu M, Jiang J, Zhu Y
The European journal of neuroscience 2025 Feb;61(3):e70010

Gal-1 promotes lung cancer cell survival by enhancing PARP1/H1.2 interaction to promote DNA repair upon DNA damage response.

Chen Y, Liu X, Li B, Xie X, Xia J, Sun H
The FEBS journal 2025 Dec;292(23):6211-6232

Galectin-3-integrin α5β1 phase separation disrupted by advanced glycation end-products impairs diabetic wound healing in rodents.

Zhang Z, Zhao Z, Huang X, Zhou L, Jiang X, Wu H, Liu C, Huang K, Wen J, Liu Y, Miller MC, Zhao Z, He Z, Wang Y, Liu S, Huang L, Yuan L, Zeng R, Cen Z, Chen A, Chen Y, Zeng G, Liu W, Hong X, Ren M, Yan L, Zhang Y, Guan D, Tian X, Cai W, Tai G, Mayo KH, Zhou Y, Li Z, Chen S
Nature communications 2025 Aug 7;16(1):7287

Acridine-Based Chalcone 1C and ABC Transporters.

Franko O, Čižmáriková M, Kello M, Michalková R, Wesołowska O, Środa-Pomianek K, Marques SM, Bednář D, Háziková V, Liška TJ, Habalová V
International journal of molecular sciences 2025 Apr 27;26(9)

Gal-1-mediated cytochrome p450 activation promotes fibroblast into myofibroblast differentiation in pulmonary fibrosis.

Weng J, Cheng Q, Yang J, Jin H, Zhang R, Guan J, Ma Y, Wang L, Chen C, Wang Z
International immunopharmacology 2024 Nov 15;141:112920

Galectin-receptor interaction: a key player in liver fibrosis induced by Schistosoma japonicum infection.

Huang Z, Liu X, Huang S, Lu F
Parasites & vectors 2024 May 20;17(1):232

Clinicopathological differences between EGFR mutated and EGFR wild-type lung adenocarcinoma with papillary predominant pattern.

Goto E, Taki T, Nomura K, Miyakami Y, Miyoshi T, Tane K, Samejima J, Aokage K, Nagamine M, Sakashita S, Sakamoto N, Kojima M, Suzuki K, Tsuboi M, Ishii G
Lung cancer (Amsterdam, Netherlands) 2024 Jun;192:107830

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis.

Xian W, Asad M, Wu S, Bai Z, Li F, Lu J, Zu G, Brintnell E, Chen H, Mao Y, Zhou G, Liao B, Wu J, Wang E, You L
Frontiers of medicine 2024 Feb;18(1):147-168

Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils.

Jiang X, Xiao X, Li H, Gong Y, Wang M, Yang H, Zhao L, Jiang Y, Wei Y, Zhao C, Li J, Chen Y, Feng S, Deng H, Ma S, Xu Y, Liu Y, Tsokos GC, Jiang M, Zhang X
Cellular & molecular immunology 2023 Nov;20(11):1339-1351

Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.

Hu Z, Zhang Y, Chen J, Luo M, Wang N, Xiao Y, He Q
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802

LGALS1 regulates cell adhesion to promote the progression of ovarian cancer.

Li X, Wang H, Jia A, Cao Y, Yang L, Jia Z
Oncology letters 2023 Aug;26(2):326

Biomimetic nanoparticles drive the mechanism understanding of shear-wave elasticity stiffness in triple negative breast cancers to predict clinical treatment.

Zheng D, Zhou J, Qian L, Liu X, Chang C, Tang S, Zhang H, Zhou S
Bioactive materials 2023 Apr;22:567-587

An Integrated Proteomics and Metabolomics Strategy for the Mechanism of Calcium Oxalate Crystal-Induced Kidney Injury.

Gao S, Chao Y, Li N, Li H, Zhao H, Liu X, Chen W, Dong X
Frontiers in medicine 2022;9:805356

Prognostic Value and Biological Function of Galectins in Malignant Glioma.

Zhu H, Liu D, Cheng L, Liu J, Wang G, Li H, Zhang Y, Mi H, Zhang S, Shu K, Yu X
Frontiers in oncology 2022;12:834307

Mesenchymal stem cells target microglia via galectin-1 production to rescue aged mice from olfactory dysfunction.

Seo Y, Ahn JS, Shin YY, Oh SJ, Song MH, Kang MJ, Oh JM, Lee D, Kim YH, Lee BC, Shin TH, Kim HS
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113347

Exosomal miR-22-3p from Mesenchymal Stem Cells Inhibits the Epithelial-Mesenchymal Transition (EMT) of Melanoma Cells by Regulating LGALS1.

Chen Y, Fang Y, Li L, Luo H, Cao T, Tu B
Frontiers in bioscience (Landmark edition) 2022 Sep 29;27(9):275

Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption.

Li M, Yang D, Yan H, Tang Z, Jiang D, Zhang J, Chi Z, Nie W, Zhen W, Yu W, Chen S, Wang Z, Yu Q, Zhang X, Yang F, Fan S, Lin X, Wang D
Developmental cell 2022 Oct 24;57(20):2365-2380.e8

Galectin‑1 binds GRP78 to promote the proliferation and metastasis of gastric cancer.

Zhang Q, Ali M, Wang Y, Sun QN, Zhu XD, Tang D, Wang W, Zhang CY, Zhou HH, Wang DR
International journal of oncology 2022 Nov;61(5)

Circular RNA RBPMS inhibits bladder cancer progression via miR-330-3p/RAI2 regulation.

Yang C, Mou Z, Zhang Z, Wu S, Zhou Q, Chen Y, Gong J, Xu C, Ou Y, Chen X, Dai X, Jiang H
Molecular therapy. Nucleic acids 2021 Mar 5;23:872-886

Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.

Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Jun 15;397:115014

Nuclear FAM289-Galectin-1 interaction controls FAM289-mediated tumor promotion in malignant glioma.

Guo XR, Wu MY, Dai LJ, Huang Y, Shan MY, Ma SN, Wang J, Peng H, Ding Y, Zhang QF, Tang JM, Ruan XZ, Li DS
Journal of experimental & clinical cancer research : CR 2019 Sep 6;38(1):394

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells.

Tummala KS, Brandt M, Teijeiro A, Graña O, Schwabe RF, Perna C, Djouder N
Cell reports 2017 Apr 18;19(3):584-600

Global secretome characterization of A549 human alveolar epithelial carcinoma cells during Mycoplasma pneumoniae infection.

Li S, Li X, Wang Y, Yang J, Chen Z, Shan S
BMC microbiology 2014 Feb 7;14:27

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human liver tissue were subjected to SDS PAGE followed by western blot with 11858-1-AP(GAL1,LGALS1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Galectin 1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Galectin 1. This antibody recognizes human,mouse,rat antigen. The Galectin 1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11858-1-AP.pdf

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