14471-1-AP

antibody from Proteintech Group

Targeting: SLC32A1 bA122O1.1, VGAT, VIAAT

Provider product page for 14471-1-AP

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Antibody data

Antibody Data
Antigen structure
References [24]
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Validations
Western blot [1]

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Product number: 14471-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14471-1-AP, RRID:AB_10644324
Product name: VGAT antibody
Antibody type: Polyclonal
Description: VGAT antibody (Cat. #14471-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC32A1 protein structure - 14471-1-AP shown in red.

Submitted references Cognitive behavioral dysregulation induced by low-level lead, cadmium, and mercury co-exposure is linked to AMPA receptor-associated with E/I imbalance.

Du G, Ouyang L, Yang S, Li Q, Li J, Zhuang X, Xie J, Zhou F, Feng C, Fan G
Ecotoxicology and environmental safety 2026 Mar 15;313:119988

Morphological Changes in Direct Pathway Striatal Neurons in a Rat Model of Tardive Dyskinesia.

Hikichi H, Nishijima H, Mori F, Kinoshita I, Suzuki C, Wakabayashi K, Tomiyama M
Movement disorders : official journal of the Movement Disorder Society 2026 Jan;41(1):234-240

Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway.

Liu Z, Shen Y, Luo AD, Ao WL, Guan SQ, Lei F, Xu ZC, Yu CY, Xu P, Huang H
Neurochemical research 2026 Feb 17;51(2):74

Auditory activity sustains adult neurogenesis and cognition through the locus coeruleus-norepinephrine system.

Liu Q, Luo X, Liang Z, Qin D, Wang M, Guo W
Cell stem cell 2026 Apr 2;33(4):605-621.e6

Morphologic changes in striatonigral neurons in a rat model of levodopa-induced dyskinesia.

Fujita M, Nishijima H, Furukawa T, Mori F, Kobayashi A, Suzuki C, Wakabayashi K, Tomiyama M
Neuroscience research 2025 Oct;219:104953

Rutin alleviates preoperative anxiety stress-induced persistent postoperative pain by inhibiting microglia-mediated abnormal synaptic engulfment in the spinal cord dorsal horn.

Zhang Y, Yang H, Zhao Y, Ni K, Sun J, Ma Z
International immunopharmacology 2025 Oct 30;164:115309

Microglial activation drives neuronal dysregulation in alcohol-induced seizure susceptibility.

Zhang S, Zhou Y, Ren Y, Shang J, Jiang A, Hong Y, Hong S, Wang C, Wang W, Chen J
Scientific reports 2025 Nov 3;15(1):38389

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy.

Chen ZP, Zhao X, Wang S, Cai R, Liu Q, Ye H, Wang MJ, Peng SY, Xue WX, Zhang YX, Li W, Tang H, Huang T, Zhang Q, Li L, Gao L, Zhou H, Hang C, Zhu JN, Li X, Liu X, Cong Q, Yan C
Nature neuroscience 2025 Jul;28(7):1404-1417

Effect of Voluntary Wheel Running on Anxiety- and Depression-Like Behaviors in Fluoride-Exposed Mice.

Qi M, Wu Y, Shi H, Liu J, Zhu R, Wang J, Rafique A, Yang B, Niu R, Zhang D, Sun Z
Biological trace element research 2025 Jul;203(7):3724-3741

Microglia-Derived Vitamin D Binding Protein Mediates Synaptic Damage and Induces Depression by Binding to the Neuronal Receptor Megalin.

Kong Y, Zhang X, Li L, Zhao T, Huang Z, Zhang A, Sun Y, Jiao J, Zhang G, Liu M, Han Y, Yang L, Zhang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(6):e2410273

Total Alkaloid Extract of Nelumbinis Plumula Promoted Sleep in PCPA-Induced Insomnia Rats by Affecting Neurotransmitters and Their Receptor Activities.

Wei W, Wang D, Li H, Tian H, Wang Z, Feng S
International journal of molecular sciences 2025 Apr 13;26(8)

Excitatory to inhibitory synaptic ratios are unchanged at presymptomatic stages in multiple models of ALS.

Bonthron C, Burley S, Broadhead MJ, Metodieva V, Grant SGN, Chandran S, Miles GB
PloS one 2024;19(8):e0306423

Targeted sonogenetic modulation of GABAergic interneurons in the hippocampal CA1 region in status epilepticus.

Xu T, Tan D, Wang Y, Gong C, Yuan J, Yang X, Wen Y, Ban Y, Liang M, Hu Y, Cao Y, Chen Y, Ran H
Theranostics 2024;14(16):6373-6391

Transmembrane protein modulates seizure in epilepsy: evidence from temporal lobe epilepsy patients and mouse models.

Zhang H, Zhou Z, Qin J, Yang J, Huang H, Yang X, Luo Z, Zheng Y, Peng Y, Chen Y, Xu Z
Experimental animals 2024 May 3;73(2):162-174

Constraint-Induced Movement Therapy Modulates Neuron Recruitment and Neurotransmission Homeostasis of the Contralesional Cortex to Enhance Function Recovery after Ischemic Stroke.

Zhang A, Xing Y, Zheng J, Li C, Hua Y, Hu J, Tian Z, Bai Y
ACS omega 2024 May 14;9(19):21612-21625

1,2-Dichloroethane causes anxiety and cognitive dysfunction in mice by disturbing GABA metabolism and inhibiting the cAMP-PKA-CREB signaling pathway.

Qin Y, Huang W, Wang Z, Wang C, Wang C, Zhang M, Wu S, Wang G, Zhao F
Ecotoxicology and environmental safety 2024 Jul 1;279:116464

Amelioration of olfactory dysfunction in a mouse model of Parkinson's disease via enhancing GABAergic signaling.

Liu XY, Wang K, Deng XH, Wei YH, Guo R, Liu SF, Zhu YF, Zhong JJ, Zheng JY, Wang MD, Ye QH, He JQ, Guo KH, Zhu JR, Huang SQ, Chen ZX, Lv CS, Wen L
Cell & bioscience 2023 Jun 3;13(1):101

Microglia participate in postoperative cognitive dysfunction by mediating the loss of inhibitory synapse through the complement pathway.

Tan X, Wang J, Yao J, Yuan J, Dai Y, Sun M, Zhang T, Yang J, Cai W, Qiu L, Sun J
Neuroscience letters 2023 Feb 6;796:137049

GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.

Bao H, Peng Z, Cheng X, Jian C, Li X, Shi Y, Zhu W, Hu Y, Jiang M, Song J, Fang F, Chen J, Shu X
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344

miR-92a-2-5p Regulates the Proliferation and Differentiation of ASD-Derived Neural Progenitor Cells.

Zhuang W, Liu H, He Z, Ju J, Gao Q, Shan Z, Lei L
Current issues in molecular biology 2022 May 24;44(6):2431-2442

Exercise Ameliorates Fluoride-induced Anxiety- and Depression-like Behavior in Mice: Role of GABA.

Cao Q, Wang J, Hao Y, Zhao F, Fu R, Yu Y, Wang J, Niu R, Bian S, Sun Z
Biological trace element research 2022 Feb;200(2):678-688

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.

Umeda T, Kimura T, Yoshida K, Takao K, Fujita Y, Matsuyama S, Sakai A, Yamashita M, Yamashita Y, Ohnishi K, Suzuki M, Takuma H, Miyakawa T, Takashima A, Morita T, Mori H, Tomiyama T
Acta neuropathologica communications 2017 Jul 31;5(1):59

Role of N-glycosylation in renal betaine transport.

Schweikhard ES, Burckhardt BC, Joos F, Fenollar-Ferrer C, Forrest LR, Kempson SA, Ziegler C
The Biochemical journal 2015 Sep 1;470(2):169-79

Mutant TDP-43 and FUS cause age-dependent paralysis and neurodegeneration in C. elegans.

Vaccaro A, Tauffenberger A, Aggad D, Rouleau G, Drapeau P, Parker JA
PloS one 2012;7(2):e31321

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The VGAT antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human VGAT. This antibody recognizes human,mouse,rat antigen. The VGAT antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 14471-1-AP.pdf

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