PPP1R16B

The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]

Description

Protein phosphatase 1 regulatory subunit 16B

Tissue specificity

Tissue enhanced (brain, lymphoid tissue)

Subcell location

Nuclear speckles, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (38805697 - 38923024)

Ensembl ID

ENSG00000101445  (ver. 103.38)

Orthologs

Mouse Ppp1r16b: ENSMUSG00000037754

UniProt

Q96T49

neXtProt

NX_Q96T49

Human splice variants
Mouse splice variants

Protein structure