Antibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 12952-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12952-1-AP, RRID:AB_2284150
- Product name
- PLK4 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PLK4 antibody (Cat. #12952-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities.
Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma.
Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development.
Effects of the PLK4 inhibitor Centrinone on the biological behaviors of acute myeloid leukemia cell lines.
The mechanism of acentrosomal spindle assembly in human oocytes.
ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification.
Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer.
Defect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse Models.
Down-regulation of Polo-like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer.
MicroRNA‑126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting polo‑like kinase 4.
Characteristic Analysis of Featured Genes Associated With Stemness Indices in Colorectal Cancer.
LncRNA SNHG1 contributes to tumorigenesis and mechanism by targeting miR-338-3p to regulate PLK4 in human neuroblastoma.
POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma.
High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer.
NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.
Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo.
Polo-like kinase 4 mediates epithelial-mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway.
Novel compound heterozygous variants in PLK4 identified in a patient with autosomal recessive microcephaly and chorioretinopathy.
Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells.
S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation.
Loss of KLF14 triggers centrosome amplification and tumorigenesis.
Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4.
Li N, Xu Y, Chen H, Lin J, AlAbdi L, Bekheirnia MR, Li G, Gofin Y, Bekheirnia N, Faqeih E, Chen L, Chang G, Tang J, Yao R, Yu T, Wang X, Fu W, Fu Q, Shen Y, Alkuraya FS, Machol K, Wang J
EBioMedicine 2024 Jan;99:104940
EBioMedicine 2024 Jan;99:104940
Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma.
Portelinha A, da Silva Ferreira M, Erazo T, Jiang M, Asgari Z, de Stanchina E, Younes A, Wendel HG
Nature communications 2023 Mar 18;14(1):1522
Nature communications 2023 Mar 18;14(1):1522
Expression Analyses of Polo-Like Kinase 4, a Gene Product Responsible for Autosomal Recessive Microcephaly and Seckel Syndrome, during Mouse Brain Development.
Hamada N, Iwamoto I, Noda M, Nishikawa M, Nagata KI
Developmental neuroscience 2022;44(6):643-650
Developmental neuroscience 2022;44(6):643-650
Effects of the PLK4 inhibitor Centrinone on the biological behaviors of acute myeloid leukemia cell lines.
Mu XR, Ma MM, Lu ZY, Liu J, Xue YT, Cao J, Zeng LY, Li F, Xu KL, Wu QY
Frontiers in genetics 2022;13:898474
Frontiers in genetics 2022;13:898474
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
Song T, Yang Y, Zhou P, Ran J, Zhang L, Wu X, Xie W, Zhong T, Liu H, Liu M, Li D, Zhao H, Zhou J
EMBO reports 2022 May 4;23(5):e54090
EMBO reports 2022 May 4;23(5):e54090
Proteomic Mapping and Targeting of Mitotic Pericentriolar Material in Tumors Bearing Centrosome Amplification.
Xie B, Pu Y, Yang F, Chen W, Yue W, Ma J, Zhang N, Jiang Y, Wu J, Lin Y, Liang X, Wang C, Zou P, Li M
Cancer research 2022 Jul 18;82(14):2576-2592
Cancer research 2022 Jul 18;82(14):2576-2592
Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer.
Oh H, Kim SG, Bae SU, Byun SJ, Kim S, Lee JH, Hwang I, Kwon SY, Lee HW
Journal of pathology and translational medicine 2022 Jan;56(1):40-47
Journal of pathology and translational medicine 2022 Jan;56(1):40-47
Defect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse Models.
Jin B, Zhang Y, Miller HD, He L, Ge D, Wang AR, You Z
Biomedicines 2022 Aug 15;10(8)
Biomedicines 2022 Aug 15;10(8)
Down-regulation of Polo-like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signaling pathway in bladder cancer.
Yang Z, Sun H, Ma W, Wu K, Peng G, Ou T, Wu S
FEBS open bio 2021 Sep;11(9):2631-2646
FEBS open bio 2021 Sep;11(9):2631-2646
MicroRNA‑126 suppresses the proliferation and migration of endothelial cells in experimental diabetic retinopathy by targeting polo‑like kinase 4.
Zheng Y, Liu Y, Wang L, Xu H, Lu Z, Xuan Y, Meng W, Ye L, Fang D, Zhou Y, Ke K, Liu Y, An M
International journal of molecular medicine 2021 Jan;47(1):151-160
International journal of molecular medicine 2021 Jan;47(1):151-160
Characteristic Analysis of Featured Genes Associated With Stemness Indices in Colorectal Cancer.
Lu Y, Zhou X, Liu Z, Wang W, Li F, Fu W
Frontiers in molecular biosciences 2020;7:563922
Frontiers in molecular biosciences 2020;7:563922
LncRNA SNHG1 contributes to tumorigenesis and mechanism by targeting miR-338-3p to regulate PLK4 in human neuroblastoma.
Zhang N, Liu FL, Ma TS, Zhang ZZJ
European review for medical and pharmacological sciences 2019 Oct;23(20):8971-8983
European review for medical and pharmacological sciences 2019 Oct;23(20):8971-8983
POLQ Overexpression Is Associated with an Increased Somatic Mutation Load and PLK4 Overexpression in Lung Adenocarcinoma.
Shinmura K, Kato H, Kawanishi Y, Yoshimura K, Tsuchiya K, Takahara Y, Hosokawa S, Kawase A, Funai K, Sugimura H
Cancers 2019 May 24;11(5)
Cancers 2019 May 24;11(5)
High PLK4 expression promotes tumor progression and induces epithelial‑mesenchymal transition by regulating the Wnt/β‑catenin signaling pathway in colorectal cancer.
Liao Z, Zhang H, Fan P, Huang Q, Dong K, Qi Y, Song J, Chen L, Liang H, Chen X, Zhang Z, Zhang B
International journal of oncology 2019 Feb;54(2):479-490
International journal of oncology 2019 Feb;54(2):479-490
NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.
Li M, Xu X, Zhang J, Liu M, Wang W, Gao Y, Sun Q, Zhang J, Lu Y, Wang F, Liu W, Zhou T, Yang Y
Cell death & disease 2019 Aug 19;10(9):628
Cell death & disease 2019 Aug 19;10(9):628
Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo.
Liu K, Fang L, Sun H, Pan Z, Zhang J, Chen J, Shao X, Wang W, Tan Y, Ding Z, Ao L, Wu C, Liu X, Li H, Wang R, Su W, Li H
Molecular cancer therapeutics 2018 May;17(5):988-1002
Molecular cancer therapeutics 2018 May;17(5):988-1002
Polo-like kinase 4 mediates epithelial-mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway.
Tian X, Zhou D, Chen L, Tian Y, Zhong B, Cao Y, Dong Q, Zhou M, Yan J, Wang Y, Qiu Y, Zhang L, Li Z, Wang H, Wang D, Ying G, Zhao Q
Cell death & disease 2018 Jan 19;9(2):54
Cell death & disease 2018 Jan 19;9(2):54
Novel compound heterozygous variants in PLK4 identified in a patient with autosomal recessive microcephaly and chorioretinopathy.
Tsutsumi M, Yokoi S, Miya F, Miyata M, Kato M, Okamoto N, Tsunoda T, Yamasaki M, Kanemura Y, Kosaki K, Saitoh S, Kurahashi H
European journal of human genetics : EJHG 2016 Dec;24(12):1702-1706
European journal of human genetics : EJHG 2016 Dec;24(12):1702-1706
Molecular basis of the STIL coiled coil oligomerization explains its requirement for de-novo formation of centrosomes in mammalian cells.
David A, Amartely H, Rabinowicz N, Shamir M, Friedler A, Izraeli S
Scientific reports 2016 Apr 14;6:24296
Scientific reports 2016 Apr 14;6:24296
S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation.
Nakagawa T, Araki T, Nakagawa M, Hirao A, Unno M, Nakayama K
Molecular and cellular biology 2015 Oct;35(20):3517-27
Molecular and cellular biology 2015 Oct;35(20):3517-27
Loss of KLF14 triggers centrosome amplification and tumorigenesis.
Fan G, Sun L, Shan P, Zhang X, Huan J, Zhang X, Li D, Wang T, Wei T, Zhang X, Gu X, Yao L, Xuan Y, Hou Z, Cui Y, Cao L, Li X, Zhang S, Wang C
Nature communications 2015 Oct 6;6:8450
Nature communications 2015 Oct 6;6:8450
Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4.
Harris RM, Weiss J, Jameson JL
Endocrinology 2011 Oct;152(10):3975-85
Endocrinology 2011 Oct;152(10):3975-85
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse lung tissue were subjected to SDS PAGE followed by western blot with 12952-1-AP(PLK4 antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human testis using 12952-1-AP(PLK4 antibody) at dilution of 1:200 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PLK4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PLK4. This antibody recognizes human,mouse,rat antigen. The PLK4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.