14-5867-82

antibody from Invitrogen Antibodies
Targeting: ITGB7
Provider product page for 14-5867-82
Flow cytometry
Other assay

Antibody data

Product number
14-5867-82 - Provider product page
Provider
Invitrogen Antibodies
Product name
Integrin beta 7 Monoclonal Antibody (FIB504), eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The FIB504 monoclonal antibody reacts with human and mouse integrin beta 7. Integrin beta 7 is a 130 kD glycoprotein which associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin alpha 4 beta 7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin alpha E beta 7 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity. Applications Reported: This FIB504 antibody has been reported for use in flow cytometric analysis and functional assays. Applications Tested: This FIB504 antibody has been tested by flow cytometric analysis of human peripheral blood cells. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered.
Reactivity
Human, Mouse
Host
Rat
Isotype
IgG
Antibody clone number
FIB504
Vial size
100 µg
Concentration
0.5 mg/mL
Storage
4° C
ITGB7 protein structure - 14-5867-82 shown in red.