12860-1-AP

antibody from Proteintech Group

Targeting: GP1BA CD42b, GP1B, GPIbalpha

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunoprecipitation (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

12860-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#12860-1-AP, RRID:AB_10644481

Product name

CD42b antibody

Antibody type

Polyclonal

Description

CD42b antibody (Cat. #12860-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, pig, mouse and has been validated for the following applications: IHC, WB,ELISA.

Reactivity

Human, Mouse, Porcine

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

WY-14643, a novel antiplatelet and antithrombotic agent targeting the GPIbα receptor.

Cao C, Yang Q, Xia X, Chen Z, Liu P, Wu X, Hu H, Ding Z, Li X
Thrombosis research 2024 Jun;238:41-51

---

Direct contact between tumor cells and platelets initiates a FAK-dependent F3/TGF-β positive feedback loop that promotes tumor progression and EMT in osteosarcoma.

Shi Q, Xu J, Chen C, Hu X, Wang B, Zeng F, Ren T, Huang Y, Guo W, Tang X, Ji T
Cancer letters 2024 Jun 1;591:216902

---

Glycosylation-Engineered Platelet Membrane-Coated Interleukin 10 Nanoparticles for Targeted Inhibition of Vascular Restenosis.

Li F, Rong Z, Chen T, Wang P, Di X, Ni L, Liu C
International journal of nanomedicine 2023;18:5011-5030

---

Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis.

Ye Y, Yang L, Leng M, Wang Q, Wu J, Wan W, Wang H, Li L, Peng Y, Chai S, Meng Z
Frontiers in pharmacology 2023;14:1255069

---

Platelet-membrane camouflaged cerium nanoparticle-embedded gelatin methacryloyl hydrogel for accelerated diabetic wound healing.

Dong H, Li J, Huang X, Liu H, Gui R
International journal of biological macromolecules 2023 Nov 1;251:126393

---

Applicability of the histidine-tryptophan-ketoglutarate solution as a machine perfusion solution for marginal liver grafts.

Iwata H, Matsuno N, Ishii D, Toriumi A, Otani M, Ohara M, Obara H, Nishikawa Y, Yokoo H
Journal of gastroenterology and hepatology 2023 May;38(5):783-790

---

Quantitative Proteomic Analysis Reveals the Mechanisms of Sinapine Alleviate Macrophage Foaming.

Liu A, Liao B, Yin S, Ye Z, He M, Li X, Liu Y, Xu Y
Molecules (Basel, Switzerland) 2023 Feb 21;28(5)

---

Apoptosis is one cause of thrombocytopenia in patients with high-altitude polycythemia.

Wang Z, Tenzing N, Xu Q, Liu H, Ye Y, Wen Y, Wuren T, Cui S
Platelets 2023 Dec;34(1):2157381

---

Platelet Membrane-Fused Circulating Extracellular Vesicles Protect the Heart from Ischemia/Reperfusion Injury.

Jiang J, Ni L, Zhang X, Wang H, Liu L, Wei M, Li G, Bei Y
Advanced healthcare materials 2023 Aug;12(21):e2300052

---

Cryo-Shocked Platelet Coupled with ROS-Responsive Nanomedicine for Targeted Treatment of Thromboembolic Disease.

Quan X, Liang X, Ding Y, Han Y, Li J, Yuan M, Li Y, Yuan Z, Wang R, Zhao Y
ACS nano 2023 Apr 11;17(7):6519-6533

---

Platelet membrane-camouflaged nanoparticles carry microRNA inhibitor against myocardial ischaemia‒reperfusion injury.

Wang T, Zhou T, Xu M, Wang S, Wu A, Zhang M, Zhou YL, Shi J
Journal of nanobiotechnology 2022 Oct 4;20(1):434

---

Blood plasma derived extracellular vesicles (BEVs): particle purification liquid chromatography (PPLC) and proteomic analysis reveals BEVs as a potential minimally invasive tool for predicting response to breast cancer treatment.

Alvarez FA, Kaddour H, Lyu Y, Preece C, Cohen J, Baer L, Stopeck AT, Thompson P, Okeoma CM
Breast cancer research and treatment 2022 Nov;196(2):423-437

---

Dietary ketone body-escalated histone acetylation in megakaryocytes alleviates chemotherapy-induced thrombocytopenia.

Xie S, Jiang C, Wu M, Ye Y, Wu B, Sun X, Lv X, Chen R, Yu W, Sun Q, Wu Y, Que R, Li H, Yang L, Liu W, Zuo J, Jensen LD, Huang G, Cao Y, Yang Y
Science translational medicine 2022 Nov 30;14(673):eabn9061

---

Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery.

Li QR, Xu HZ, Xiao RC, Liu Y, Tang JM, Li J, Yu TT, Liu B, Li LG, Wang MF, Han N, Xu YH, Wang C, Komatsu N, Zhao L, Peng XC, Li TF, Chen X
Drug delivery 2022 Dec;29(1):937-949

---

Downregulation of Interleukin-13 Receptor α2 Inhibits Angiogenic Formation Mediated by Chitinase 3-Like 1 in Late Atherosclerotic Lesions of apoE(-/-) Mice.

Xue Q, Chen L, Yu J, Sun K, Ye L, Zheng J
Frontiers in physiology 2021;12:690109

---

A blood circulation-prolonging peptide anchored biomimetic phage-platelet hybrid nanoparticle system for prolonged blood circulation and optimized anti-bacterial performance.

Jin P, Wang L, Sha R, Liu L, Qian J, Ishimwe N, Zhang W, Qian J, Zhang Y, Wen L
Theranostics 2021;11(5):2278-2296

---

Involvement of Neutrophil Extracellular Traps in Cerebral Arteriovenous Malformations.

Shimada K, Yamaguchi I, Ishihara M, Miyamoto T, Sogabe S, Miyake K, Tada Y, Kitazato KT, Kanematsu Y, Takagi Y
World neurosurgery 2021 Nov;155:e630-e636

---

Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy.

Zhao G, Li J, Fangfang Lv, Wang X, Dong Q, Liu D, Zhang J, Li Z, Zhou X, Liu H
ACS biomaterials science & engineering 2021 Nov 8;7(11):5154-5164

---

Beneficial effects of end-ischemic oxygenated machine perfusion preservation for split-liver transplantation in recovering graft function and reducing ischemia-reperfusion injury.

Ishii D, Matsuno N, Gochi M, Iwata H, Shonaka T, Nishikawa Y, Obara H, Yokoo H, Furukawa H
Scientific reports 2021 Nov 19;11(1):22608

---

GSK669, a NOD2 receptor antagonist, inhibits thrombosis and oxidative stress via targeting platelet GPVI.

Pan G, Chang L, Zhang J, Liu Y, Hu L, Zhang S, Zhang J, Qiao J, Jakopin Ž, Hu H, Dong J, Ding Z
Biochemical pharmacology 2021 Jan;183:114315

---

Anti-platelet aggregation of Panax notoginseng triol saponins by regulating GP1BA for ischemic stroke therapy.

Xu ZY, Xu Y, Xie XF, Tian Y, Sui JH, Sun Y, Lin DS, Gao X, Peng C, Fan YJ
Chinese medicine 2021 Jan 19;16(1):12

---

Protective Effect of Taurine on Apoptosis of Spinal Cord Cells in Diabetic Neuropathy Rats.

Inam-U-Llah, Shi X, Zhang M, Li K, Wu P, Suleman R, Shahbaz M, Taj A, Piao F
Advances in experimental medicine and biology 2019;1155:875-887

---

Von Willebrand factor protects against acute CCl(4)-induced hepatotoxicity through phospho-p38 MAPK signaling pathway inhibition.

Sun HJ, Chen J, Zhang H, Ni B, van Velkinburgh JC, Liu Y, Wu YZ, Yang X
Immunologic research 2017 Oct;65(5):1046-1058

---

Transforming growth factor β- and interleukin 13-producing mast cells are associated with fibrosis in bone marrow.

Nakayama S, Yokote T, Hiraoka N, Akioka T, Nishiwaki U, Miyoshi T, Iwaki K, Fumimoto A, Masuda Y, Hatooka J, Fujimoto M, Nishimura Y, Tsuji M
Human pathology 2017 Apr;62:180-186

---

Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.

Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, Dong S, Yang F, Zhang L, Zhong X, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:33

---

TNF-α alters the inflammatory secretion profile of human first trimester placenta.

Siwetz M, Blaschitz A, El-Heliebi A, Hiden U, Desoye G, Huppertz B, Gauster M
Laboratory investigation; a journal of technical methods and pathology 2016 Apr;96(4):428-38

---

Adhering maternal platelets can contribute to the cytokine and chemokine cocktail released by human first trimester villous placenta.

Blaschitz A, Siwetz M, Schlenke P, Gauster M
Placenta 2015 Nov;36(11):1333-6

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

A431 cells were subjected to SDS PAGE followed by western blot with 12860-1-AP(GP1BA antibody) at dilution of 1:500

Sample type

cell line

Immunoprecipitation

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

IP Result of anti-GP1BA (IP:12860-1-AP, 3ug; Detection:12860-1-AP 1:500) with A431 cells lysate 3000ug.

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human spleen using 12860-1-AP(GP1BA antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The CD42b antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CD42b. This antibody recognizes human antigen. The CD42b antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.

Appendix

12860-1-AP.pdf

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