67172-1-Ig

antibody from Proteintech Group

Targeting: FBXO32 ATROGIN1, Fbx32, MAFbx

Provider product page for 67172-1-Ig

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Antibody data

Antibody Data
Antigen structure
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Product number: 67172-1-Ig - Provider product page
Provider: Proteintech Group
Product name: FBXO32 antibody
Antibody type: Monoclonal
Description: FBXO32 antibody (Cat. #67172-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Pig, Rat, mouse and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat, Porcine
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 3C2G3
Vial size: 20ul, 150ul

FBXO32 protein structure - 67172-1-Ig shown in red.

Submitted references Elevated circulating GDF11 and its role in age-related sarcopenia: insights from clinical, transcriptomic, and in vitro analyses.

Chen R, Dai X, Wang H, Zhang T, Zhang Z, Liu Y, Fan Z
Frontiers in aging 2026;7:1736069

Exercise preconditioning prevents immobilization-induced skeletal muscle atrophy by activating Prmt1-p38/ATF2-Sesn1 signaling axis in C57BL/6J mice.

Yang X, Zou Y, Wang H, Niu Y, Fu L
Sports medicine and health science 2026 Mar;8(2):197-209

Sijunzi decoction alleviates cancer cachexia myatrophy by suppressing M2 polarization of tumor-associated macrophages via the MCT1/lactate/H3K18 lactylation pathway.

Nie D, Zhang Y, Jia R, Fang Z, Zhu G, Xu B, Guo T, Zhang H
Journal of ethnopharmacology 2026 Jun 12;364:121500

Resistance exercise alleviates skeletal muscle atrophy through reduction of oxidative stress via Sestrin1 in C57BL/6J mice.

Yang X, Peng J, Huang Y, Liu S, Niu Y, Fu L
Sports medicine and health science 2026 Jan;8(1):50-60

Therapeutic effects of Total flavonoids of Epimedium Folium on sarcopenia via modulation of gut microbiota and bile acid metabolism.

Zhang Y, Pan Z, Shi J, Zhang J, Chai Y, Zhao Y, Liu W, Yuan W
Experimental gerontology 2026 Jan;213:113001

Computer assisted discovery of novel nicotinamide phosphoribosyltransferase agonists to combat muscle atrophy.

Li L, Wang R, Zhu J, Cao F, Min J, Ouyang D, Lin L
Bioorganic chemistry 2026 Jan;168:109296

Composite dietary fiber alleviates obesity-induced skeletal muscle atrophy by regulating gut microbiota-derived short-chain fatty acids in mice.

Xie Y, Deng D, Wang S, Li Z, Mo T, Wang Y, Guo H
NPJ science of food 2026 Jan 9;10(1):49

Antitumor efficacy and molecular mechanism of lenvatinib combined with vitamin K2 against hepatocellular carcinoma.

Zhang Y, Chen D, Qian X, Long C, Zheng Z
World journal of surgical oncology 2026 Feb 6;24(1)

Sodium butyrate ameliorates muscle atrophy in type 2 diabetes-related sarcopenia via the PI3K/Akt/FoxO1 pathway.

Song CY, Yang Y, Hong K
Tissue & cell 2026 Aug;101:103487

Mechanisms of skeletal muscle atrophy in type 2 diabetes mellitus.

Yang J, Wang Y, Xu Y, Jia X, Lu F
Frontiers in physiology 2025;16:1607873

Investigating the pharmacodynamic mechanism of Erxian decoction to alleviate sarcopenia generated by ovarian aging through the ER-mediated estrogen signaling pathway.

You F, Wang N, Yang J, Dong Y, Liu N, Zhao P
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120355

TAK-242 inhibits toll-like receptor-4 signaling and attenuates cancer-associated muscle atrophy via the p38-C/EBPβ pathway.

You Y, Su Z, Wang H, Liu S, Wang J, Qiu F, Jiang Z, Wang J, Li Y, Zhang G
Journal of molecular histology 2025 Oct 22;56(6):347

MiR-126-5p Derived From Bone Marrow Mesenchymal Stem Cell Exosomes Promotes Skeletal Muscle Regeneration by Regulating FBXO32/MyoD Signaling.

Yan Y, Zheng M, Wang X, Fu T, Qi J, Wei X, Sun Y, Lu J, Luo X, Wang Y, Wang H
Acta physiologica (Oxford, England) 2025 Nov;241(11):e70114

Aerobic plus resistance exercise attenuates skeletal muscle atrophy induced by dexamethasone through the HDAC4/FoxO3a pathway.

Liang D, Wang D, Zheng X, Xiang H, Liu S, Yu C, Tian J, Ma J, Niu Y
Cellular signalling 2025 Mar;127:111581

Polygonati Rhizoma Prevents Glucocorticoid-Induced Growth Inhibition of Muscle via Promoting Muscle Angiogenesis Through Deoxycholic Acid.

Shi S, Li R, Han Y, Xie J, Wang S, Liu J, Wan F, Hou G, Liu Z, Sun X, Zuo B, Jia Z, Mei Z, Song T
Journal of cachexia, sarcopenia and muscle 2025 Jun;16(3):e13853

Anti-sarcopenic effects of active vitamin D through modulation of anabolic and catabolic signaling pathways in human skeletal muscle: A randomized controlled trial.

Kawahara T, Inazu T, Mizuno S, Tominaga N, Toda M, Toyama N, Kawahara C, Suzuki G, DPVD Research Group
Metabolism: clinical and experimental 2025 Jul;168:156240

Early-life exercise extends healthspan but not lifespan in mice.

Feng M, Li M, Lou J, Wu G, Gao T, Wu F, Tan Y, Zhang N, Zhao Y, Zhao L, Li J, Shi C, Zhang X, Liu J, Gao F
Nature communications 2025 Jul 9;16(1):6328

Taurine Attenuates Disuse Muscle Atrophy Through Modulation of the xCT-GSH-GPX4 and AMPK-ACC-ACSL4 Pathways.

Liu X, Chen Y, Zhang L, Qi Z, Yang L, Huang C, Wang L, Lin D
Antioxidants (Basel, Switzerland) 2025 Jul 10;14(7)

SESN2 mediates resistance training-induced improvements in exercise performance and energy metabolism in C57BL/6J mice.

Huang Y, Sun S, Yang X, Li X, Zhou Y, Liu S, Niu Y, Fu L
Experimental cell research 2025 Jul 1;450(1):114617

HouShiHeiSan attenuates sarcopenia in middle cerebral artery occlusion (MCAO) rats.

Qi H, Gao Y, Zhang Z, Zhang X, Tian D, Jiang Y, Zhang L, Zeng N, Yang R
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118917

Umbilical cord mesenchymal stem cell-derived exosomal Follistatin inhibits fibrosis and promotes muscle regeneration in mice by influencing Smad2 and AKT signaling.

Hu H, Yin Y, Zhou H, Jiang B, Cai T, Wu S, Guo S
Experimental cell research 2025 Jan 15;444(2):114396

Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.

Song J, Yang M, Xia L, Wang L, Wang K, Xiang Y, Cheng J, Chen J, Liu J, Zhao R, Liu F, Sun Z, Hou X, Zang N, Chen L
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13717

Electroacupuncture Improves Anorectal Function in Neurogenic Fecal Incontinence Rats, Related to Reversing Anal Sphincter Atrophy and Enhancing Muscle Satellite Cell Activity.

He J, Wan Q, Du L, Qin Q, Zhao L, Dong Q
Neurogastroenterology and motility 2025 Dec;37(12):e70138

NAD(+) Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.

Song J, Sun Y, Zang N, Liu X, Chen J, Wang K, Xia L, Chen J, Zhao R, Liu F, Hou X, Chen L, Cheng J, Zhang W
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70142

IGF2BP3 binds to FBXO32 to activate the cyclic guanosine monophosphate-protein kinase G pathway, promoting gastric cancer progression.

Si Y, Tian B, Zhang R, Xuan MD, Liu KY, Jiao J, Han SS, Li HF, Hu YH, Zhao HY, He WJ, Wang J, Liu T, Yu WF
World journal of gastroenterology 2025 Dec 14;31(46):111631

Cerium Oxide Nanoparticles Achieve Long-Lasting Senescence Inhibition in an Aging Mouse Model of Sarcopenia via Reactive Oxygen Species Scavenging and CILP2 Downregulation.

Lien WC, Yu YL, Liang YJ, Wang CY, Lin YC, Chang HC, Lin FH, David Wang HM
Small science 2025 Aug;5(8):2500208

Upregulation of FAM129B protects against glucocorticoid-induced skeletal muscle atrophy via regulating long non-coding RNA NEAT1.

Wang Y, Lu Y, Hou J, Wang Y, Luo L, Lu Z, Xie Y, Cai L, Xiao Z
International journal of biological macromolecules 2025 Apr;300:140120

Burn-Induced Gut Microbiota Dysbiosis Aggravates Skeletal Muscle Atrophy by Tryptophan-Kynurenine Mediated AHR Pathway Activation.

Gao S, Leng Y, Qiu Z, Li K, Li J, Peng J, Xie W, Lei S, Xia Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(14):e2409296

F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression.

Li F, Yu H, Zhang Y, Ma Y, Chen X, Zhang J, Sun L, Guo R, Wu Y, Zheng P, Wang X, Bie P, He F, Zhang L, Xie C, Xiong H
Nature communications 2025 Apr 30;16(1):4060

Ginsenoside Rg1 Attenuates Muscle Atrophy in Hyperglycemic Conditions, Inactivity and Protein Deprivation Models via AKT/mTOR Pathway Activation.

He X, Li Y, Chen J, Zhang L, Huang Y, Zhou Y, Li J
Current molecular medicine 2025 Apr 23;

Transcutaneous carbon dioxide suppresses skeletal muscle atrophy in a mouse model of oral squamous cell carcinoma.

Sasaki A, Takeda D, Kawai H, Tadokoro Y, Murakami A, Yatagai N, Arimoto S, Nagatsuka H, Akashi M, Hasegawa T
PloS one 2024;19(4):e0302194

PEI/MMNs@LNA-542 nanoparticles alleviate ICU-acquired weakness through targeted autophagy inhibition and mitochondrial protection.

Wang Y, Xu Y, Zhao T, Ma YJ, Qin W, Hu WL
Open life sciences 2024;19(1):20220952

The Potential Related Genes and Mechanisms Involved in Improving the Treadmill Exercise Ability of APP/PS1 Mice.

Zhao Z, Wu X, Wu W, Tang Y, Meng X, Peng M, Tang C, Zheng L, Liu W
International journal of molecular sciences 2024 Sep 24;25(19)

Irisin Ameliorates Muscle Atrophy by Inhibiting the Upregulation of the Ubiquitin‒Proteasome System in Chronic Kidney Disease.

Wang S, Pan Y, Pang Q, Zhang A
Calcified tissue international 2024 Nov;115(5):712-724

A network pharmacology-based study to investigate the mechanism of curcumin-regulated regenerative repair of quadriceps femoris muscle in KOA rats.

Ye H, Li ZQ, Yang JM, Long Y, Zhong YB, Wu Y, Wang MY
European journal of pharmacology 2024 Nov 5;982:176910

The Role of Grifola frondosa Polysaccharide in Preventing Skeletal Muscle Atrophy in Type 2 Diabetes Mellitus.

She Y, Ma Y, Zou P, Peng Y, An Y, Chen H, Luo P, Wei S
Life (Basel, Switzerland) 2024 Jun 21;14(7)

The Contrasting Effects of Two Distinct Exercise Training Modalities on Exhaustive Exercise-Induced Muscle Damage in Mice May Be Associated with Alterations in the Gut Microbiota.

Zhang Y, Wang C, Lang H, Yu H, Zhou M, Rao X, Zhang Q, Yi L, Zhu J, Mi M
International journal of molecular sciences 2024 Jul 17;25(14)

β‑carotene attenuates muscle wasting in cancer cachexia by regulating myogenesis and muscle atrophy.

Kim Y, Oh Y, Kim YS, Shin JH, Lee YS, Kim Y
Oncology reports 2024 Jan;51(1)

Exercise-induced modulation of myokine irisin on muscle-bone unit in the rat model of post-traumatic osteoarthritis.

Shang X, Hao X, Hou W, Liu J, Chi R, Deng X, Pan C, Xu T
Journal of orthopaedic surgery and research 2024 Jan 9;19(1):49

Dietary supplementation with inulin improves burn-induced skeletal muscle atrophy by regulating gut microbiota disorders.

Gao S, Zhao X, Leng Y, Xia Z
Scientific reports 2024 Jan 28;14(1):2328

Effects of exercise, metformin, and combination treatments on type 2 diabetic mellitus-induced muscle atrophy in db/db mice: Crosstalk between autophagy and the proteasome.

Xiang M, Yuan X, Zhang N, Zhang L, Liu Y, Liu J, Gao Y, Xu Y, Sun W, Tang Q, Zhang Y, Lu J
Journal of physiology and biochemistry 2024 Feb;80(1):235-247

5'-Cytimidine Monophosphate Ameliorates H(2)O(2)-Induced Muscular Atrophy in C2C12 Myotubes by Activating IRS-1/Akt/S6K Pathway.

Wu X, Zhu N, He L, Xu M, Li Y
Antioxidants (Basel, Switzerland) 2024 Feb 19;13(2)

Tanshinone IIA alleviates inflammation-induced skeletal muscle atrophy by regulating mitochondrial dysfunction.

Han D, Chen YB, Zhao K, Li HZ, Chen XY, Zhu GZ, Tu C, Gao JW, Zhuang JS, Wu ZY, Zhong ZM
Archives of biochemistry and biophysics 2024 Dec;762:110215

Daidzein improves muscle atrophy caused by lovastatin by regulating the AMPK/FOXO3a axis.

Wang K, Zeng H, Yang H
Chinese medicine 2024 Dec 31;19(1):180

CCL2 signaling promotes skeletal muscle wasting in non-tumor and breast tumor models.

Alissa N, Fang WB, Medrano M, Bergeron N, Kozai Y, Hu Q, Redding C, Thyfault J, Hamilton-Reeves J, Berkland C, Cheng N
Disease models & mechanisms 2024 Aug 1;17(8)

Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.

Huang Y, Jiang C, Li X, Liu S, Niu Y, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111

FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression.

Wu J, Wen T, Marzio A, Song D, Chen S, Yang C, Zhao F, Zhang B, Zhao G, Ferri A, Cheng H, Ma J, Ren H, Chen QY, Yang Y, Qin S
Cell death & disease 2024 Apr 20;15(4):282

Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy.

Martin TG, Juarros MA, Cleveland JC Jr, Bristow MR, Ambardekar AV, Buttrick PM, Leinwand LA
JACC. Basic to translational science 2023 Sep;8(9):1043-1056

The Warburg effect drives cachectic states in patients with pancreatobiliary adenocarcinoma.

Li Q, Zhang D, Sui X, Song T, Hu L, Xu X, Wang X, Wang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23144

N-acetylcysteine alleviates oxidative stress and apoptosis and prevents skeletal muscle atrophy in type 1 diabetes mellitus through the NRF2/HO-1 pathway.

Ding Q, Sun B, Wang M, Li T, Li H, Han Q, Liao J, Tang Z
Life sciences 2023 Sep 15;329:121975

Unraveling the gut microbiota and short-chain fatty acids characteristics and associations in a cancer cachexia mouse model.

Liu H, Cheng Y, Qu Y, Wu G
Microbial pathogenesis 2023 Oct;183:106332

The metabolite butyrate produced by gut microbiota inhibits cachexia-associated skeletal muscle atrophy by regulating intestinal barrier function and macrophage polarization.

Liu H, Xi Q, Tan S, Qu Y, Meng Q, Zhang Y, Cheng Y, Wu G
International immunopharmacology 2023 Nov;124(Pt B):111001

Resistance exercise alleviates dexamethasone-induced muscle atrophy via Sestrin2/MSTN pathway in C57BL/6J mice.

Yang Y, Yang X, Huang Y, Liu S, Niu Y, Fu L
Experimental cell research 2023 Nov 1;432(1):113779

Tumor-derived semaphorin 3D promoting cancer cachexia via regulating hypothalamic pro-opiomelanocortin neurons.

Zhang Y, Xi Q, Zhong M, Jiang Y, Zhuang Q, Ding Z, Tan S, Wang J, Liu H, Zhang Z, Zhou B, Wu G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Jun;37(6):e22980

Downregulation of BASP1 Promotes Temozolomide Resistance in Gliomas via Epigenetic Activation of the FBXO32/NF-κB/MGMT Axis.

Liao X, Li Z, Zheng H, Qian W, Zhang S, Chen S, Li X, Tang M, Xu Y, Yu R, Li M, Song L, Li J
Molecular cancer research : MCR 2023 Jul 5;21(7):648-663

Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.

Huang KC, Chiang YF, Huang TC, Chen HY, Lin PH, Ali M, Hsia SM
Journal of cachexia, sarcopenia and muscle 2023 Feb;14(1):182-197

Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.

Shi Y, Zhang ZW, Du MM, Wu J, Li JX
Journal of ethnopharmacology 2023 Aug 10;312:116458

Mesenchymal stromal cells ameliorate diabetes-induced muscle atrophy through exosomes by enhancing AMPK/ULK1-mediated autophagy.

Song J, Liu J, Cui C, Hu H, Zang N, Yang M, Yang J, Zou Y, Li J, Wang L, He Q, Guo X, Zhao R, Yan F, Liu F, Hou X, Sun Z, Chen L
Journal of cachexia, sarcopenia and muscle 2023 Apr;14(2):915-929

Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells.

Xu K, Liu Q, Huang W, Chu Y, Fan W, Liu J, He Y, Huang F
International journal of molecular sciences 2023 Apr 22;24(9)

Myostatin/AKT/FOXO Signaling Is Altered in Human Non-Ischemic Dilated Cardiomyopathy.

Hildebrandt L, Dieterlen MT, Klaeske K, Haunschild J, Saeed D, Eifert S, Borger MA, Jawad K
Life (Basel, Switzerland) 2022 Sep 12;12(9)

RAI14 Promotes Melanoma Progression by Regulating the FBXO32/c-MYC Pathway.

Xu J, Shi P, Xia F, Zhao X, Chen J, Geng R, Cui H, Yang L
International journal of molecular sciences 2022 Oct 10;23(19)

mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.

Liu M, Yue Z, Zhang B, Li F, Liu L, Li F
Metabolites 2022 Aug 25;12(9)

Phosphorylation of Dynamin-Related Protein 1 (DRP1) Regulates Mitochondrial Dynamics and Skeletal Muscle Wasting in Cancer Cachexia.

Mao X, Gu Y, Sui X, Shen L, Han J, Wang H, Xi Q, Zhuang Q, Meng Q, Wu G
Frontiers in cell and developmental biology 2021;9:673618

Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue.

Wang L, Zheng ZG, Meng L, Zhu L, Li P, Chen J, Yang H
Cell biology and toxicology 2021 Jun;37(3):441-460

Treadmill running prevents atrophy differently in fast- versus slow-twitch muscles in a rat model of rheumatoid arthritis.

Kamada Y, Toyama S, Arai Y, Inoue H, Nakagawa S, Fujii Y, Kaihara K, Kishida T, Mazda O, Takahashi K
Journal of muscle research and cell motility 2021 Dec;42(3-4):429-441

Protective effects of taurine against muscle damage induced by diquat in 35 days weaned piglets.

Wen C, Li F, Guo Q, Zhang L, Duan Y, Wang W, Li J, He S, Chen W, Yin Y
Journal of animal science and biotechnology 2020;11:56

Identification key genes, key miRNAs and key transcription factors of lung adenocarcinoma.

Li J, Li Z, Zhao S, Song Y, Si L, Wang X
Journal of thoracic disease 2020 May;12(5):1917-1933

Differential activation of the calpain system involved in individualized adaptation of different fast-twitch muscles in hibernating Daurian ground squirrels.

Ma X, Chang H, Wang Z, Xu S, Peng X, Zhang J, Yan X, Lei T, Wang H, Gao Y
Journal of applied physiology (Bethesda, Md. : 1985) 2019 Aug 1;127(2):328-341

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