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- Antigen structure
- References [188]
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- Product number
- 21997-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- LAMP1 antibody
- Antibody type
- Polyclonal
- Description
- LAMP1 antibody (Cat. #21997-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease.
Lipotoxic hepatocyte-derived UBQLN1-enriched small extracellular vesicles activate hepatic stellate cells to promote hepatic fibrosis.
Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance.
Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism.
YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy.
pH-responsive ZIF-8@quercetin nanoparticles induce pyroptosis for targeted gastric cancer therapy.
MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway.
Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson's disease pathogenesis.
Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress.
Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway.
Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine.
Polystyrene nanoplastics-induced methuosis in brain microvascular endothelial cells: Rescue via ESCRT membrane repair system.
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
ER‑α36 knockdown is associated with lysosomal dysfunction and proliferation inhibition in liver cancer cells.
Mechanisms of Intermittent Theta-Burst Stimulation Upregulates TFEB and Restores Autophagy to Play a Neuroprotective Role in the Acute Phase After Cerebral Ischemia Reperfusion.
TJ0113 attenuates fibrosis in metabolic dysfunction-associated steatohepatitis by inducing mitophagy.
USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3.
Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction.
Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial Aβ clearance through the endo-lysosomal pathway.
GRASP55 regulates sorting and maturation of the lysosomal enzyme β-hexosaminidase A.
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA.
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes.
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.
Binding of collagen I to integrins alleviates UVB-caused mitochondrial disorders in human keratinocytes HaCaT through enhancement of F-actin polymerization.
Bioinformatics analysis and preliminary validation of autophagy-related genes in asthma disease.
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
Selenoprotein M protects cardiac endothelial cell integrity against high-glucose stress via enhancing Parkin-mediated mitophagy.
Knockdown of regulator of Calcineurin 2 promotes transcription factor EB-mediated lipophagy to prevent non-alcoholic fatty liver disease.
CCAAT/Enhancer-Binding Protein Beta Nitration Participates in Hyperhomocysteinemia-Induced Cardiomyocyte Autophagic Flux Blockage by Inhibiting Transcription Factor EB Transcription.
Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis.
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration.
OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model.
Ubiquitination of CD47 Regulates Innate Anti-Tumor Immune Response.
Therapeutic effect of dihydroartemisinin on Alzheimer's disease model mice with senile macular degeneration.
Biomolecule-tailored chiral nickel oxide nanozymes amplify autophagy-mediated tumor ablation via synergistic photodynamic-chemodynamic therapy.
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Renal tubular VMP1 protects against acute kidney injury via modulating autophagy and autophagy-independent pathway.
Hypoxia-induced secretory autophagy in cancer-associated fibroblasts promotes ECM remodelling through serglycin secretion in oral squamous cell carcinoma.
PI3K/mTOR Inhibitor Induces Context-Dependent Apoptosis and Methuosis in Cancer Cells.
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.
Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease.
CD133 (+) Vesicles Mediate Resistance to RAS-ERK Inhibition Regulated by YAP Activation in Liver Cancer Cells.
TFEB orchestrates ferritinophagy and ferroptosis in ionophore drug-induced hepatotoxicity: unveiling a novel therapeutic avenue.
Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis.
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
The ROGDI protein mutated in Kohlschutter-Tonz syndrome is a novel subunit of the Rabconnectin-3 complex implicated in V-ATPase assembly.
Design, Synthesis, and Biological Evaluation of Naphthalimide-Polyamine Conjugate as a Potential Anti-Colorectal Cancer Agent.
ZKSCAN3 affects the autophagy‑lysosome pathway through TFEB in Parkinson's disease.
cGAS-mediated antibacterial immunotherapy against tuberculosis by macrophage-targeted manganese dioxide nanoagonist.
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke.
PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation.
St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.
Sesamin alleviates lipid accumulation induced by elaidic acid in L02 cells through TFEB regulated autophagy.
Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L.
Euphorbia factor L2 alleviated gouty inflammation by specifically suppressing both the priming and activation of NLRP3 inflammasome.
Efficacy comparison in cap VLPs of PCV2 and PCV3 as swine vaccine vehicle.
Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response.
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A.
GL-V9 Promotes Autophagy-Mediated YAP1 Degradation and Activates Mitochondrial Apoptosis in PDAC Cells.
NEU4-mediated desialylation enhances the activation of the oncogenic receptors for the dissemination of ovarian carcinoma.
SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.
Nuciferine Alleviates High-Fat Diet- and ApoE(-/-)-Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway.
Epidermal Stem Cell Derived Exosomes Alleviate Excessive Autophagy Induced Endothelial Cell Apoptosis by Delivering miR200b-3p to Diabetic Wounds.
Melanin-concentrating hormone receptor 1 is discarded by exosomes after internalization.
LAMP1 controls CXCL10-CXCR3 axis mediated inflammatory regulation of macrophage polarization during inflammatory stimulation.
SARS-CoV-2 NSP2 as a Potential Delivery Vehicle for Proteins.
eIF2α-mediated integrated stress response links multiple intracellular signaling pathways to reprogram vascular smooth muscle cell fate in carotid artery plaque.
Tangzhiqing decoction attenuates cognitive dysfunction of mice with type 2 diabetes by regulating AMPK/mTOR autophagy signaling pathway.
Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions.
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome.
Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry.
Nuciferine protects bovine hepatocytes against free fatty acid-induced oxidative damage by activating the transcription factor EB/peroxisome proliferator-activated receptor γ coactivator 1 alpha pathway.
Hexamethylene amiloride synergizes with venetoclax to induce lysosome-dependent cell death in acute myeloid leukemia.
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Investigation of Glycosylphosphatidylinositol (GPI)-Plasma Membrane Interaction in Live Cells and the Influence of GPI Glycan Structure on the Interaction.
Molecular basis for the different PCV2 susceptibility of T-lymphoblasts in Landrace and Piétrain pigs.
Regulatory roles of NAMPT and NAD(+) metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment.
Microglial EPOR Contribute to Sevoflurane-induced Developmental Fine Motor Deficits Through Synaptic Pruning in Mice.
Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy.
Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.
Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions.
TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy.
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)-Iridium(III) Imidazole-Phenanthroline Complexes with Aggregation-Induced Emission Properties.
Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy.
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren's disease.
Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.
Astrocytic AT1R deficiency ameliorates Aβ-induced cognitive deficits and synaptotoxicity through β-arrestin2 signaling.
Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
The lysosome-mitochondrion crosstalk engaged in silver nanoparticles-disturbed mitochondrial homeostasis.
Cuproptosis-immunotherapy using PD-1 overexpressing T cell membrane-coated nanosheets efficiently treats tumor.
Functional of tongue sole (Cynoglossus semilaevis) gamma-interferon-inducible lysosomal thiol reductase with implications in innate immune reponse depend on CXXC active site.
Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis.
Ethyl Gallate Inhibits Bovine Viral Diarrhea Virus by Promoting IFITM3 Expression, Lysosomal Acidification and Protease Activity.
Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells.
Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect.
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
Canine distemper virus N protein induces autophagy to facilitate viral replication.
Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates.
Complex metabolic disharmony in PMM2-CDG paves the way to new therapeutic approaches.
PPARγ inhibited tumor immune escape by inducing PD-L1 autophagic degradation.
PPARγ agonist pioglitazone enhances colorectal cancer immunotherapy by inducing PD-L1 autophagic degradation.
Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase.
Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H(+)-driven lysosomal pyridoxine exporter.
Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.
Mitophagy bridges DNA sensing with metabolic adaption to expand lung cancer stem-like cells.
PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.
Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.
LAMP3 transfer via extracellular particles induces apoptosis in Sjögren's disease.
A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB.
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Inhibition of CK2/ING4 Pathway Facilitates Non-Small Cell Lung Cancer Immunotherapy.
DR region of NKAα1 is a target to ameliorate hepatic lipid metabolism disturbance in obese mice.
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
PRKX down-regulates TAK1/IRF7 signaling in the antiviral innate immunity of black carp Mylopharyngodon piceus.
TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication.
Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy.
Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease.
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways.
Compensatory engulfment and Müller glia reactivity in the absence of microglia.
LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.
Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice.
A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation.
Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.
GRN-/- iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis.
Sulforaphane Ameliorates Hepatic Lipid Metabolism via Modulating Lipophagy In Vivo and In Vitro.
Multi-omics analysis unravels dysregulated lysosomal function and lipid metabolism involved in sub-chronic particulate matter-induced pulmonary injury.
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis.
Molecular Characterization of AMPA-Receptor-Containing Vesicles.
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia.
TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis.
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer.
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice.
Thioxothiazolidin derivative, 4-OST, inhibits melanogenesis by enhancing the specific recruitment of tyrosinase-containing vesicles to lysosome.
Circ_0030998 promotes tumor proliferation and angiogenesis by sponging miR-567 to regulate VEGFA in colorectal cancer.
Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE(-/-) mice.
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation.
Identification of Compound CB-2 as a Novel Late-Stage Autophagy Inhibitor Exhibits Inhibitory Potency against A549 Cells.
1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.
Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells.
Meg3 Induces EMT and Invasion of Glioma Cells via Autophagy.
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.
mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.
The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization.
An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice.
Butyrate-mediated autophagy inhibition limits cytosolic Salmonella Infantis replication in the colon of pigs treated with a mixture of Lactobacillus and Bacillus.
Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes.
LncRNA expression profile during autophagy and Malat1 function in macrophages.
Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease.
Pyrroloquinoline quinine ameliorates doxorubicin-induced autophagy-dependent apoptosis via lysosomal-mitochondrial axis in vascular endothelial cells.
Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.
Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.
Identification and functional characterization of interferon-γ-inducible lysosomal thiol reductase (GILT) gene in common Chinese cuttlefish Sepiella japonica.
Circular RNA profiling provides insights into their subcellular distribution and molecular characteristics in HepG2 cells.
Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation.
Sufentanil impairs autophagic degradation and inhibits cell migration in NCI-H460 in vitro.
Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.
Acetyl-CoA Synthetase 2 Promotes Cell Migration and Invasion of Renal Cell Carcinoma by Upregulating Lysosomal-Associated Membrane Protein 1 Expression.
Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction.
The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.
Differential signaling pathways are initiated in macrophages during infection depending on the intracellular fate of Chlamydia spp.
LIN28A inhibits lysosome‑associated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells.
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Molecular and biological characterization of gamma-interferon-inducible lysosomal thiol reductase in silver carp (Hypophthalmichthys molitrix).
Entosis Acts as a Novel Way within Sertoli Cells to Eliminate Spermatozoa in Seminiferous Tubule.
Upregulation of the lncRNA Meg3 induces autophagy to inhibit tumorigenesis and progression of epithelial ovarian carcinoma by regulating activity of ATG3.
Altered expression of lysosomal associated membrane protein 1 in esophageal squamous cell carcinoma.
Identification and characterization of an endoplasmic reticulum localization motif.
Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV).
Zhao J, Zou J, Zhou C, Wang Y, Liu Y, Zhou Y, Wang Y, Zhang X, Yang H, Yin H, Bai D, Zhao Y, Lu N
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e21681
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e21681
Lipotoxic hepatocyte-derived UBQLN1-enriched small extracellular vesicles activate hepatic stellate cells to promote hepatic fibrosis.
Yang F, Chen Y, Wang Y, Zheng G, Abouelnazar F, Fan L, Wang Y, Yan Y
Autophagy 2026 Mar 13;:1-23
Autophagy 2026 Mar 13;:1-23
Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance.
Li SC, Shao SZ, Zhang YH, Zhou Y, Shang WT, Gao Y, He QB, Guo QL, Guo CY, Zhang XB
World journal of gastroenterology 2026 Feb 28;32(8):113299
World journal of gastroenterology 2026 Feb 28;32(8):113299
Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism.
Byrd A, Marmorale LJ, Marcinowski S, Dykstra MM, Addison V, Barmada SJ, Buchan JR
The Journal of cell biology 2026 Feb 2;225(2)
The Journal of cell biology 2026 Feb 2;225(2)
YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA3-induced microlipophagy.
Chai J, Han L, Mo D, Bai Y, Yang Y, Ding Y, Chen S, Kong X, Zhu X, Xu L, Dai H, Wang W
Redox biology 2026 Apr;91:104085
Redox biology 2026 Apr;91:104085
pH-responsive ZIF-8@quercetin nanoparticles induce pyroptosis for targeted gastric cancer therapy.
Xu Q, Jin X, Song S, Zhang H, Ding H, Liu C, Li L, Peng S, Cheng Y, Zhong M, Li L, Zhu J, Dong S, Zhang G
Materials today. Bio 2026 Apr;37:102806
Materials today. Bio 2026 Apr;37:102806
MCL1 promotes porcine epidemic diarrhea virus replication by modulating arachidonic acid metabolic pathway.
Shang H, Yang S, Sun M, Zhao Y, Guo R, Wang W, Qian B, Li Y, Hu M, Bian X, Cao Q, Li C, Fan B, Li B
PLoS pathogens 2026 Apr;22(4):e1014170
PLoS pathogens 2026 Apr;22(4):e1014170
Nurr1 deficiency impairs autophagy-lysosomal function through GBA-dependent transcriptional regulation in Parkinson's disease pathogenesis.
Cheng C, Yang H, Tian L, Ni Y, Jia C, Le W, Wang Q
Frontiers in aging neuroscience 2025;17:1612389
Frontiers in aging neuroscience 2025;17:1612389
Targeted autophagic clearance of Tau protects against Alzheimer's disease through amelioration of Tau-mediated lysosomal stress.
Yoon BH, Kim J, Sengupta S, Park CJ, Ko M, Kang JH, Ko YT, Kim Y, Lim SM, Bae Y, Choi M, Jang Y, Kwon HJ, Son HJ, Kim HJ, Sim T, Chang KA, Lee MS
Theranostics 2025;15(17):9240-9260
Theranostics 2025;15(17):9240-9260
Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway.
Zhou X, Guo Q, Qiao Q, Fang X, Jiang Y, Wang X, Hu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157059
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157059
Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine.
Bai Y-Z, Xu H, Liu Y-G, Sun Y, Xu S-J, Wang M-X, Wang Q, Tian Z-J, Leng C-L, Wang G, An T-Q, Cai X-H, Zhang H-L, Tang Y-D
Journal of virology 2025 Sep 23;99(9):e0063625
Journal of virology 2025 Sep 23;99(9):e0063625
Polystyrene nanoplastics-induced methuosis in brain microvascular endothelial cells: Rescue via ESCRT membrane repair system.
Yin S, Kang Y, Du W, Tan X, Wang Z, Shao L, Liu J
Ecotoxicology and environmental safety 2025 Sep 15;303:118800
Ecotoxicology and environmental safety 2025 Sep 15;303:118800
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
Yang R, Zhan Y, Deng Z, Zhang J, Chen S, Zhang Y, Fu H, Meng X, Wu J, Gu Y, Huang Q, Wang C, Xie J
Redox biology 2025 Oct;86:103793
Redox biology 2025 Oct;86:103793
ER‑α36 knockdown is associated with lysosomal dysfunction and proliferation inhibition in liver cancer cells.
He H, Wang X, Wei Z, Wang A, Fang X, He H, Wu Z, Shu X, Sun B, Chen Q, Huang X, Zhou H, Liu Y, Fu Z
Molecular medicine reports 2025 Oct;32(4)
Molecular medicine reports 2025 Oct;32(4)
Mechanisms of Intermittent Theta-Burst Stimulation Upregulates TFEB and Restores Autophagy to Play a Neuroprotective Role in the Acute Phase After Cerebral Ischemia Reperfusion.
Zhang XY, Zhao YN, Gui LH, Han PP, Huang YY, Bi X
Neurochemical research 2025 Nov 27;51(1):4
Neurochemical research 2025 Nov 27;51(1):4
TJ0113 attenuates fibrosis in metabolic dysfunction-associated steatohepatitis by inducing mitophagy.
Huang CL, Qi-En S, Cen XF, Ye T, Qu HS, Chen SJ, Liu D, Xia HG, Xu CF, Zhu JS
International immunopharmacology 2025 May 27;156:114678
International immunopharmacology 2025 May 27;156:114678
USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3.
Chen Y, Ye B, Xu D, Lin W, Fang Z, Qu X, Han X, Luo W, Chen C, Huang W, Zhou H, Wu G, Wang Y, Liang G
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1643-1658
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1643-1658
Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction.
Zhu L, Hu J, Wu X, Zhang J, Xu X, Huang X, Tian B, Zhao CX, Du Y, Wu L
Nature communications 2025 Mar 28;16(1):3017
Nature communications 2025 Mar 28;16(1):3017
Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial Aβ clearance through the endo-lysosomal pathway.
Jing X, Zhao Y, Wang G, Tian W
International immunopharmacology 2025 Mar 26;150:114281
International immunopharmacology 2025 Mar 26;150:114281
GRASP55 regulates sorting and maturation of the lysosomal enzyme β-hexosaminidase A.
Akaaboune SR, Javed A, Bui S, Wierenga A, Wang Y
Molecular biology of the cell 2025 Mar 1;36(3):ar30
Molecular biology of the cell 2025 Mar 1;36(3):ar30
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
Lin J, Sun Y, Huang H, Yu C, Kuang W, Wang Y, Zhu L
Molecular neurobiology 2025 Jun;62(6):7054-7074
Molecular neurobiology 2025 Jun;62(6):7054-7074
YTHDF1 differentiates the contributing roles of mTORC1 in aging.
Xu C, Yu C, Zhang J, Zhang Z, Zhang J, Meng Y, Wang M, Wen M, Chen J, Ning Y, Chen X, Gu J, Su W, Liu B
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
Molecular cell 2025 Jun 5;85(11):2194-2210.e8
ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA.
Ji H, Jiang W, Zhang J, Liu M, Su D, Lei J, Li L, Zheng M, Liu T, Liu Z, Cao Q, Xu L, Xiong S, Wen Z
Cell reports 2025 Jun 24;44(6):115851
Cell reports 2025 Jun 24;44(6):115851
ATP7A Maintains Bactericidal Function of Neutrophils and Macrophages via Regulating the Formation and Activation of Phagolysosomes.
Jing Y, Shi J, Xie Z, Shen Z, Zhang J, Wang F, Li K, Su J, Liu JX
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70661
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70661
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
Cheng Z, Gao H, Shi P, Zhang A, Chen X, Chen Y, Gan W, Zhao K, Li S, Yang C, Zhang Y
Bone research 2025 Jun 12;13(1):62
Bone research 2025 Jun 12;13(1):62
Inhibition of CDC27 O-GlcNAcylation coordinates the antitumor efficacy in multiple myeloma through the autophagy-lysosome pathway.
Wu HQ, Qin RC, Li WJ, Liu JN, Deng C, Zheng ZH, Zheng JP, Liu Y, Meng YF, Tang C, Tan HM, Duan FF, Tang Y, Xiao F, Lu LW, Dai XY, Ma KY
Acta pharmacologica Sinica 2025 Jul;46(7):2041-2055
Acta pharmacologica Sinica 2025 Jul;46(7):2041-2055
Binding of collagen I to integrins alleviates UVB-caused mitochondrial disorders in human keratinocytes HaCaT through enhancement of F-actin polymerization.
Zhu Y, Ji T, San Z, Cao R, Hayashi T, Mizuno K, Hattori S, Fujisaki H, Liu W, Ikejima T
Journal of photochemistry and photobiology. B, Biology 2025 Jul;268:113170
Journal of photochemistry and photobiology. B, Biology 2025 Jul;268:113170
Bioinformatics analysis and preliminary validation of autophagy-related genes in asthma disease.
Sun B, Huang H, An R, Wei B, Yue X
Scientific reports 2025 Jul 1;15(1):21475
Scientific reports 2025 Jul 1;15(1):21475
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Chen Y, Shen J, Yuan M, Li H, Li Y, Zheng S, Han B, Zhang C, Liu S, Sun Q, Wu J
Journal of advanced research 2025 Jan;67:331-348
Journal of advanced research 2025 Jan;67:331-348
The cholesterol metabolite 25-hydroxycholesterol suppresses porcine deltacoronavirus via lipophagy inhibition and mTORC1 modulation.
Zhang JL, Wang XF, Li JL, Duan C, Wang JF
Veterinary research 2025 Jan 31;56(1):23
Veterinary research 2025 Jan 31;56(1):23
Selenoprotein M protects cardiac endothelial cell integrity against high-glucose stress via enhancing Parkin-mediated mitophagy.
Zhao B, Tan WL, Yu BB, Fan J, Liu C, Liu J, Liu Z
Molecular and cellular endocrinology 2025 Jan 1;595:112392
Molecular and cellular endocrinology 2025 Jan 1;595:112392
Knockdown of regulator of Calcineurin 2 promotes transcription factor EB-mediated lipophagy to prevent non-alcoholic fatty liver disease.
Shan L, Guo P, Wen M, Sun Y, Gao F, Zhang K, Zhang N, Yang B
Toxicology and applied pharmacology 2025 Feb;495:117210
Toxicology and applied pharmacology 2025 Feb;495:117210
CCAAT/Enhancer-Binding Protein Beta Nitration Participates in Hyperhomocysteinemia-Induced Cardiomyocyte Autophagic Flux Blockage by Inhibiting Transcription Factor EB Transcription.
Chai J, Xu J, Zhang S, Yan W, Chen S, Zhu X, Luo C, Wang W
Antioxidants & redox signaling 2025 Feb;42(4-6):165-183
Antioxidants & redox signaling 2025 Feb;42(4-6):165-183
Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis.
An D, Zhang C, Zhou P, Wang Y, Meng S, Chen Y, Xu W, Xuan J, Xiong J, Cheng J, Gao R, Wang J, Chen X
CNS neuroscience & therapeutics 2025 Feb;31(2):e70293
CNS neuroscience & therapeutics 2025 Feb;31(2):e70293
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration.
Cheng Z, Gan W, Xiang Q, Zhao K, Gao H, Chen Y, Shi P, Zhang A, Li G, Song Y, Feng X, Yang C, Zhang Y
Autophagy 2025 Feb;21(2):352-373
Autophagy 2025 Feb;21(2):352-373
OTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model.
Song X, Liu T, Yu L, Ji Q, Guo X, Zong R, Li Y, Huang G, Xue Q, Fu Q, Liu B, Zheng Y, Chen L, Gao C, Liu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2406700
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2406700
Ubiquitination of CD47 Regulates Innate Anti-Tumor Immune Response.
Gou Q, Yan B, Duan Y, Guo Y, Qian J, Shi J, Hou Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2412205
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2412205
Therapeutic effect of dihydroartemisinin on Alzheimer's disease model mice with senile macular degeneration.
Han G, Xuewu G, Meng Z, Yuejing W, Yuchun W, Keshuang Z, Hongbo Y
European journal of medical research 2025 Feb 5;30(1):81
European journal of medical research 2025 Feb 5;30(1):81
Biomolecule-tailored chiral nickel oxide nanozymes amplify autophagy-mediated tumor ablation via synergistic photodynamic-chemodynamic therapy.
Pang W, Shao Y, Xu H, Li T, Wu L, Liu Z, Zhang L, Chen W, Li Y, Xu D, Cheng J, Xu X
Materials today. Bio 2025 Dec;35:102303
Materials today. Bio 2025 Dec;35:102303
Overcoming ELDR-mediated cancer cell survival in vitro and in vivo via sphingomyelin-driven TRPML1 inactivation and TFEB suppression through lysosomal HSP70 targeting.
Chen H, Zhu M, Zhao Z, Jiang Y, Wang H, Liu Y, Chen Y, Li H, Xun C, Hui H
Pharmacological research 2025 Dec;222:108050
Pharmacological research 2025 Dec;222:108050
Renal tubular VMP1 protects against acute kidney injury via modulating autophagy and autophagy-independent pathway.
Yang W, Jia M, Zhou F, Zhang M, Qu S, Zeng C, Zhu X, Gu S, Xuan J, Liu Z, Zen K
Autophagy 2025 Dec;21(12):2792-2808
Autophagy 2025 Dec;21(12):2792-2808
Hypoxia-induced secretory autophagy in cancer-associated fibroblasts promotes ECM remodelling through serglycin secretion in oral squamous cell carcinoma.
Zhang Y, Tao C, Yin X, Wang Z, Zhang Y, Yu J, Wang Y, Han W
Clinical and translational medicine 2025 Dec;15(12):e70556
Clinical and translational medicine 2025 Dec;15(12):e70556
PI3K/mTOR Inhibitor Induces Context-Dependent Apoptosis and Methuosis in Cancer Cells.
Hua X, Chen P, Zeng W, Han Y, Guo Y, Chen Y, Li C, Du Y, Ma M, Dong S
Pharmaceuticals (Basel, Switzerland) 2025 Dec 4;18(12)
Pharmaceuticals (Basel, Switzerland) 2025 Dec 4;18(12)
STUB1-mediated PGC-1α ubiquitination promotes postoperative cognitive dysfunction in aged mice via modulating autophagy-lysosome machinery.
Shen QH, Xia JY, Ma Y, Xu SS
European journal of medical research 2025 Dec 30;31(1):173
European journal of medical research 2025 Dec 30;31(1):173
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.
Li Y, Sheng M, Li W, Liu S, Wang B, Liu B, Luo M, Zhou X, Xia Q, Hong S, Zheng Z, Cheng SY, Jiang X, Li J, Huang T
Nature communications 2025 Dec 13;17(1):440
Nature communications 2025 Dec 13;17(1):440
Microplastics exacerbate ferroptosis via mitochondrial reactive oxygen species-mediated autophagy in chronic obstructive pulmonary disease.
Wei YY, Chen TT, Zhang DW, Zhang Y, Li F, Ding YC, Wang MY, Zhang L, Chen KG, Fei GH
Autophagy 2025 Aug;21(8):1717-1743
Autophagy 2025 Aug;21(8):1717-1743
CD133 (+) Vesicles Mediate Resistance to RAS-ERK Inhibition Regulated by YAP Activation in Liver Cancer Cells.
Zhang S, Feng X, Quan E, Kaneko K, Feng GS
bioRxiv : the preprint server for biology 2025 Aug 2;
bioRxiv : the preprint server for biology 2025 Aug 2;
TFEB orchestrates ferritinophagy and ferroptosis in ionophore drug-induced hepatotoxicity: unveiling a novel therapeutic avenue.
Wang J, Song X, Hui Y, Dong B, Gong J, Zhao Y, Ji H, Qiu Y, Jiang S, Guo D, Gao X
Free radical biology & medicine 2025 Aug 16;236:116-133
Free radical biology & medicine 2025 Aug 16;236:116-133
Moxibustion ameliorates abnormal subchondral bone remodeling by promoting ACSL1-mediated autophagy to degrade NLRP3 in osteoarthritis.
Chen X, Fu L, Huang Y, Liao Q, Zou B, Yuan L, Liu G
Chinese medicine 2025 Aug 11;20(1):125
Chinese medicine 2025 Aug 11;20(1):125
MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2.
Gao X, Jia S, Gao L, Chen S, Zhang Y, Liang X, Zhang L, Zhang B, Meng C
Free radical biology & medicine 2025 Aug 1;235:213-230
Free radical biology & medicine 2025 Aug 1;235:213-230
The ROGDI protein mutated in Kohlschutter-Tonz syndrome is a novel subunit of the Rabconnectin-3 complex implicated in V-ATPase assembly.
Winkley SR, Kane PM
The Journal of biological chemistry 2025 Apr;301(4):108381
The Journal of biological chemistry 2025 Apr;301(4):108381
Design, Synthesis, and Biological Evaluation of Naphthalimide-Polyamine Conjugate as a Potential Anti-Colorectal Cancer Agent.
Dai F, Cao Y, Zhu C, Li Y, Ma X, Wang S, Liu H, Xie X, Gao L, Wang Y, Wang C
Chemistry & biodiversity 2025 Apr;22(4):e202401873
Chemistry & biodiversity 2025 Apr;22(4):e202401873
ZKSCAN3 affects the autophagy‑lysosome pathway through TFEB in Parkinson's disease.
Yang M, Lin S, Sun B, Chen W, Liu J, Chen M
Biomedical reports 2025 Apr;22(4):74
Biomedical reports 2025 Apr;22(4):74
cGAS-mediated antibacterial immunotherapy against tuberculosis by macrophage-targeted manganese dioxide nanoagonist.
Liao K, Chen R, Zhang J, Ruan Y, Huang X, Huang Y, Xia J, Zhao D, Chen L, Zhao Y, Yang F, Xu JF, Shen L, Pi J
Acta biomaterialia 2025 Apr;196:471-486
Acta biomaterialia 2025 Apr;196:471-486
Deubiquitination of RIPK3 by OTUB2 potentiates neuronal necroptosis after ischemic stroke.
Mei F, Deng D, Cao Z, Lou L, Chen K, Hu M, Zhu Z, Shen J, Zhang J, Liang J, Huang J, Bao M, Waisman A, Wang X
EMBO molecular medicine 2025 Apr;17(4):679-695
EMBO molecular medicine 2025 Apr;17(4):679-695
PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation.
Wu H, Zhang Z, Xue Y, Guo J, Ouyang Z, Cao Z, Guo W, Zhang Q, Wang M, Gu X
Journal of medicinal chemistry 2025 Apr 24;68(8):8190-8207
Journal of medicinal chemistry 2025 Apr 24;68(8):8190-8207
St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo.
Guo Y, Wang S, Liu Q, Dong Y, Liu Y
PloS one 2024;19(12):e0316268
PloS one 2024;19(12):e0316268
Sesamin alleviates lipid accumulation induced by elaidic acid in L02 cells through TFEB regulated autophagy.
Liang X, Zhang T, Cheng X, Yuan H, Yang N, Yi Y, Li X, Zhang F, Sun J, Li Z, Wang X
Frontiers in nutrition 2024;11:1511682
Frontiers in nutrition 2024;11:1511682
Deapioplatycodin D promotes cell senescence induced by P21 through the mediation of incomplete mitophagy via BNIP3L.
Li Y, Xiao P, Sun Y, Li Y, Zhao H, Sun J, Wang X, Han X, Jin N, Li X, Bao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117215
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117215
Euphorbia factor L2 alleviated gouty inflammation by specifically suppressing both the priming and activation of NLRP3 inflammasome.
Li Y, Zhuang Y, Chen Y, Wang G, Tang Z, Zhong Y, Zhang Y, Wu L, Ji X, Zhang Q, Pan B, Luo Y
International immunopharmacology 2024 Sep 10;138:112598
International immunopharmacology 2024 Sep 10;138:112598
Efficacy comparison in cap VLPs of PCV2 and PCV3 as swine vaccine vehicle.
Qiu H, Sun M, Wang N, Zhang S, Deng Z, Xu H, Yang H, Gu H, Fang W, He F
International journal of biological macromolecules 2024 Oct;278(Pt 3):134955
International journal of biological macromolecules 2024 Oct;278(Pt 3):134955
Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response.
Li ZM, Duan SH, Yu TM, Li B, Zhang WK, Zhou CM, Yu XJ
Autophagy 2024 Oct;20(10):2133-2145
Autophagy 2024 Oct;20(10):2133-2145
GRASP55 Regulates Sorting and Maturation of the Lysosomal Enzyme β-Hexosaminidase A.
Akaaboune SR, Javed A, Bui S, Wierenga A, Wang Y
bioRxiv : the preprint server for biology 2024 Oct 17;
bioRxiv : the preprint server for biology 2024 Oct 17;
GL-V9 Promotes Autophagy-Mediated YAP1 Degradation and Activates Mitochondrial Apoptosis in PDAC Cells.
Liu H, Lin Z, Guo Y, Zhou Y, Li W
Pharmaceuticals (Basel, Switzerland) 2024 Oct 10;17(10)
Pharmaceuticals (Basel, Switzerland) 2024 Oct 10;17(10)
NEU4-mediated desialylation enhances the activation of the oncogenic receptors for the dissemination of ovarian carcinoma.
Shi J, Zhou R, Wang S, Liu Y, Tian B, Liu Y, Chen Y, Hu T, Mu Y, Wang S, Shao X, Yan J, Qu P, Wei D, Yang S, Shi Y, Li J, Wang L
Oncogene 2024 Nov;43(49):3556-3569
Oncogene 2024 Nov;43(49):3556-3569
SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.
Huang G, Zhang J, Xu Y, Wu F, Fu Y, Zhang X, Yin H, You Y, Zhao P, Liu W, Shen J, Yin J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405907
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405907
Nuciferine Alleviates High-Fat Diet- and ApoE(-/-)-Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway.
Qiu J, Le Y, Liu N, Chen L, Jiang Y, Wang Y, Fan X, Rong X, Yu Z, Li S, Dou X
Journal of agricultural and food chemistry 2024 Nov 6;72(44):24417-24431
Journal of agricultural and food chemistry 2024 Nov 6;72(44):24417-24431
Epidermal Stem Cell Derived Exosomes Alleviate Excessive Autophagy Induced Endothelial Cell Apoptosis by Delivering miR200b-3p to Diabetic Wounds.
Xu H, Yang H, Wang Z, Tang Q, Cao X, Chen C, Dong Y, Xu Z, Lv D, Rong Y, Chen M, Tang B, Deng W, Zhu J, Hu Z
The Journal of investigative dermatology 2024 May;144(5):1134-1147.e2
The Journal of investigative dermatology 2024 May;144(5):1134-1147.e2
Melanin-concentrating hormone receptor 1 is discarded by exosomes after internalization.
Yamada R, Michimae M, Hamamoto A, Takemori H
Biochemical and biophysical research communications 2024 May 28;710:149917
Biochemical and biophysical research communications 2024 May 28;710:149917
LAMP1 controls CXCL10-CXCR3 axis mediated inflammatory regulation of macrophage polarization during inflammatory stimulation.
Ye Y, Li L, Kang H, Wan Z, Zhang M, Gang B, Liu J, Liu G, Gu W
International immunopharmacology 2024 May 10;132:111929
International immunopharmacology 2024 May 10;132:111929
SARS-CoV-2 NSP2 as a Potential Delivery Vehicle for Proteins.
Zheng N, Liu S, Chen J, Xu Y, Cao W, Lin J, Lu G, Zhang G
Molecular pharmaceutics 2024 Mar 4;21(3):1149-1159
Molecular pharmaceutics 2024 Mar 4;21(3):1149-1159
eIF2α-mediated integrated stress response links multiple intracellular signaling pathways to reprogram vascular smooth muscle cell fate in carotid artery plaque.
Luo J, Zhang X, Li W, Wang T, Cui S, Li T, Wang Y, Xu W, Ma Y, Yang B, Luo Y, Yang G, Xu R, Jiao L
Heliyon 2024 Mar 15;10(5):e26904
Heliyon 2024 Mar 15;10(5):e26904
Tangzhiqing decoction attenuates cognitive dysfunction of mice with type 2 diabetes by regulating AMPK/mTOR autophagy signaling pathway.
Yao W, Zhang Q, Zhao Y, Xu X, Zhang S, Wang X
Journal of ethnopharmacology 2024 Mar 1;321:117536
Journal of ethnopharmacology 2024 Mar 1;321:117536
Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions.
Hou Y, Chu X, Park JH, Zhu Q, Hussain M, Li Z, Madsen HB, Yang B, Wei Y, Wang Y, Fang EF, Croteau DL, Bohr VA
Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Jun;20(6):4212-4233
Alzheimer's & dementia : the journal of the Alzheimer's Association 2024 Jun;20(6):4212-4233
Targeting DRP1 with Mdivi-1 to correct mitochondrial abnormalities in ADOA+ syndrome.
Lin Y, Wang D, Li B, Wang J, Xu L, Sun X, Ji K, Yan C, Liu F, Zhao Y
JCI insight 2024 Jun 25;9(15)
JCI insight 2024 Jun 25;9(15)
Pseudorabies virus inhibits progesterone-induced inactivation of TRPML1 to facilitate viral entry.
Su BQ, Yang GY, Wang J, Ming SL, Chu BB
PLoS pathogens 2024 Jan;20(1):e1011956
PLoS pathogens 2024 Jan;20(1):e1011956
Nuciferine protects bovine hepatocytes against free fatty acid-induced oxidative damage by activating the transcription factor EB/peroxisome proliferator-activated receptor γ coactivator 1 alpha pathway.
Fang Z, Jiang X, Wang S, Tai W, Jiang Q, Loor JJ, Yu H, Hao X, Chen M, Shao Q, Song Y, Lei L, Liu G, Du X, Li X
Journal of dairy science 2024 Jan;107(1):625-640
Journal of dairy science 2024 Jan;107(1):625-640
Hexamethylene amiloride synergizes with venetoclax to induce lysosome-dependent cell death in acute myeloid leukemia.
Jiang X, Huang K, Sun X, Li Y, Hua L, Liu F, Huang R, Du J, Zeng H
iScience 2024 Jan 19;27(1):108691
iScience 2024 Jan 19;27(1):108691
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Ouyang Z, Ma M, Zhang Z, Wu H, Xue Y, Jian Y, Yin K, Yu S, Zhao C, Guo W, Gu X
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Investigation of Glycosylphosphatidylinositol (GPI)-Plasma Membrane Interaction in Live Cells and the Influence of GPI Glycan Structure on the Interaction.
Kundu S, Jaiswal M, Babu Mullapudi V, Guo J, Kamat M, Basso KB, Guo Z
Chemistry (Weinheim an der Bergstrasse, Germany) 2024 Feb 7;30(8):e202303047
Chemistry (Weinheim an der Bergstrasse, Germany) 2024 Feb 7;30(8):e202303047
Molecular basis for the different PCV2 susceptibility of T-lymphoblasts in Landrace and Piétrain pigs.
Ouyang Y, Nauwynck HJ
Veterinary research 2024 Feb 19;55(1):22
Veterinary research 2024 Feb 19;55(1):22
Regulatory roles of NAMPT and NAD(+) metabolism in uterine leiomyoma progression: Implications for ECM accumulation, stemness, and microenvironment.
Chiang YF, Huang KC, Huang TC, Chen HY, Ali M, Al-Hendy A, Huang PS, Hsia SM
Redox biology 2024 Dec;78:103411
Redox biology 2024 Dec;78:103411
Microglial EPOR Contribute to Sevoflurane-induced Developmental Fine Motor Deficits Through Synaptic Pruning in Mice.
He D, Shi X, Liang L, Zhao Y, Ma S, Cao S, Liu B, Gao Z, Zhang X, Fan Z, Kuang F, Zhang H
Neuroscience bulletin 2024 Dec;40(12):1858-1874
Neuroscience bulletin 2024 Dec;40(12):1858-1874
Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy.
Lu YY, Fang YY, Wang SS, Guo J, Song JL, Zhu L, Lin ZK, Wang R, Zhang SY, Qiu WS, Qi WW
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156161
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156161
Osmundacetone ameliorates Alzheimer's-like pathologies by inhibiting β-amyloid fibrillation, oxidative damage and neuroinflammation in APP/PS1 transgenic mice.
Zhao LX, Ren H, Su JY, Zhang Q, He DL, Wu TY, Zhang YH, Wang ZY, Fan YG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156091
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156091
Redox homeostasis of one-carbon metabolism-dependent reprogramming is critical for RCC progression under exogenous serine/glycine-deprived conditions.
Wang H, Fan M, Liu S, Qu M, Hou X, Hou J, Xu Y, Shang X, Liu C, He M, Gao J, Chen J, Li X
BMC cancer 2024 Dec 18;24(1):1515
BMC cancer 2024 Dec 18;24(1):1515
TFEB signaling promotes autophagic degradation of NLRP3 to attenuate neuroinflammation in diabetic encephalopathy.
Lin Y, Cheng L, Chen Y, Li W, Guo Q, Miao Y
American journal of physiology. Cell physiology 2024 Dec 1;327(6):C1481-C1496
American journal of physiology. Cell physiology 2024 Dec 1;327(6):C1481-C1496
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
Wang Y, Gong J, Heng N, Hu Y, Wang R, Wang H, He W, Zhu N, Hu Z, Hao H, Zhu H, Zhao S
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)-Iridium(III) Imidazole-Phenanthroline Complexes with Aggregation-Induced Emission Properties.
Sun Y, Liu J, Li Q, Zhang X, Cao Z, Bu L, Cao S, Liu X, Yuan XA, Liu Z
Inorganic chemistry 2024 Aug 5;63(31):14641-14655
Inorganic chemistry 2024 Aug 5;63(31):14641-14655
Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy.
Lin Z, Li LY, Chen L, Jin C, Li Y, Yang L, Li CZ, Qi CY, Gan YY, Zhang JR, Wang P, Ni LB, Wang GF
Acta pharmacologica Sinica 2024 Apr;45(4):815-830
Acta pharmacologica Sinica 2024 Apr;45(4):815-830
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
Pileggi CA, Parmar G, Elkhatib H, Stewart CM, Alecu I, Côté M, Bennett SAL, Sandhu JK, Cuperlovic-Culf M, Harper ME
Current research in neurobiology 2023;5:100112
Current research in neurobiology 2023;5:100112
Salivary gland LAMP3 mRNA expression is a possible predictive marker in the response to hydroxychloroquine in Sjögren's disease.
Nakamura H, Tanaka T, Ji Y, Zheng C, Afione SA, Warner BM, Oliveira FR, Motta ACF, Rocha EM, Noguchi M, Atsumi T, Chiorini JA
PloS one 2023;18(2):e0282227
PloS one 2023;18(2):e0282227
Lysosome-Associated Membrane Protein 3 Induces Lysosome-Dependent Cell Death by Impairing Autophagic Caspase 8 Degradation in the Salivary Glands of Individuals With Sjögren's Disease.
Nakamura H, Tanaka T, Zheng C, Afione SA, Warner BM, Noguchi M, Atsumi T, Chiorini JA
Arthritis & rheumatology (Hoboken, N.J.) 2023 Sep;75(9):1586-1598
Arthritis & rheumatology (Hoboken, N.J.) 2023 Sep;75(9):1586-1598
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.
Yu H, Hao Z, Liu X, Wei Z, Tan R, Liu X, Chen Q, Chen Y, Zhou H, Liu Y, Fu Z
Environmental toxicology 2023 Sep;38(9):2100-2110
Environmental toxicology 2023 Sep;38(9):2100-2110
Astrocytic AT1R deficiency ameliorates Aβ-induced cognitive deficits and synaptotoxicity through β-arrestin2 signaling.
Chen X, Gao R, Song Y, Xu T, Jin L, Zhang W, Chen Z, Wang H, Wu W, Zhang S, Zhang G, Zhang N, Chang L, Liu H, Li H, Wu Y
Progress in neurobiology 2023 Sep;228:102489
Progress in neurobiology 2023 Sep;228:102489
Targeted Degradation of Alpha-Synuclein by Autophagosome-Anchoring Chimera Peptides.
Tong Y, Zhu W, Chen J, Zhang W, Xu F, Pang J
Journal of medicinal chemistry 2023 Sep 14;66(17):12614-12628
Journal of medicinal chemistry 2023 Sep 14;66(17):12614-12628
The lysosome-mitochondrion crosstalk engaged in silver nanoparticles-disturbed mitochondrial homeostasis.
Liu J, Huang Z, Yin S, Zhou X, Jiang Y, Shao L
The Science of the total environment 2023 Sep 1;889:164078
The Science of the total environment 2023 Sep 1;889:164078
Cuproptosis-immunotherapy using PD-1 overexpressing T cell membrane-coated nanosheets efficiently treats tumor.
Liu T, Zhou Z, Zhang M, Lang P, Li J, Liu Z, Zhang Z, Li L, Zhang L
Journal of controlled release : official journal of the Controlled Release Society 2023 Oct;362:502-512
Journal of controlled release : official journal of the Controlled Release Society 2023 Oct;362:502-512
Functional of tongue sole (Cynoglossus semilaevis) gamma-interferon-inducible lysosomal thiol reductase with implications in innate immune reponse depend on CXXC active site.
Liu M, Tao M, Li J, Sang M, Wu X, Luo H, Zhang J
Developmental and comparative immunology 2023 Oct;147:104901
Developmental and comparative immunology 2023 Oct;147:104901
Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis.
Zhang JJ, Song CG, Wang M, Zhang GQ, Wang B, Chen X, Lin P, Zhu YM, Sun ZC, Wang YZ, Jiang JL, Li L, Yang XM, Chen ZN
Journal of pharmaceutical analysis 2023 Oct;13(10):1135-1152
Journal of pharmaceutical analysis 2023 Oct;13(10):1135-1152
Ethyl Gallate Inhibits Bovine Viral Diarrhea Virus by Promoting IFITM3 Expression, Lysosomal Acidification and Protease Activity.
Zhang L, Yang G, Wang J, Zhang J, Chen K, Xiong X, Zhu Y, Xu C, Wang J
International journal of molecular sciences 2023 May 12;24(10)
International journal of molecular sciences 2023 May 12;24(10)
Apigenin Alleviated High-Fat-Diet-Induced Hepatic Pyroptosis by Mitophagy-ROS-CTSB-NLRP3 Pathway in Mice and AML12 Cells.
Meng Z, Gao M, Wang C, Guan S, Zhang D, Lu J
Journal of agricultural and food chemistry 2023 May 10;71(18):7032-7045
Journal of agricultural and food chemistry 2023 May 10;71(18):7032-7045
Dual targets of lethal apoptosis and protective autophagy in liver cancer with periplocymarin elicit a limited therapeutic effect.
Hao Y, Song T, Wang M, Li T, Zhao C, Li T, Hou Y, He H
International journal of oncology 2023 Mar;62(3)
International journal of oncology 2023 Mar;62(3)
TFEB coordinates autophagy and pyroptosis as hepatotoxicity responses to ZnO nanoparticles.
Pei X, Liu D, Li J, Li L, Ding X, Zhang W, Li Z, Xu G, Li C, Li D
The Science of the total environment 2023 Mar 20;865:161242
The Science of the total environment 2023 Mar 20;865:161242
Canine distemper virus N protein induces autophagy to facilitate viral replication.
Chen F, Guo Z, Zhang R, Zhang Z, Hu B, Bai L, Zhao S, Wu Y, Zhang Z, Li Y
BMC veterinary research 2023 Mar 15;19(1):60
BMC veterinary research 2023 Mar 15;19(1):60
Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates.
Tong Y, Zhu W, Chen J, Wen T, Xu F, Pang J
Journal of medicinal chemistry 2023 Jun 22;66(12):7926-7942
Journal of medicinal chemistry 2023 Jun 22;66(12):7926-7942
Complex metabolic disharmony in PMM2-CDG paves the way to new therapeutic approaches.
Himmelreich N, Kikul F, Zdrazilova L, Honzik T, Hecker A, Poschet G, Lüchtenborg C, Brügger B, Strahl S, Bürger F, Okun JG, Hansikova H, Thiel C
Molecular genetics and metabolism 2023 Jul;139(3):107610
Molecular genetics and metabolism 2023 Jul;139(3):107610
PPARγ inhibited tumor immune escape by inducing PD-L1 autophagic degradation.
Gou Q, Che S, Chen M, Chen H, Shi J, Hou Y
Cancer science 2023 Jul;114(7):2871-2881
Cancer science 2023 Jul;114(7):2871-2881
PPARγ agonist pioglitazone enhances colorectal cancer immunotherapy by inducing PD-L1 autophagic degradation.
Jia X, Qian J, Chen H, Liu Q, Hussain S, Jin J, Shi J, Hou Y
European journal of pharmacology 2023 Jul 5;950:175749
European journal of pharmacology 2023 Jul 5;950:175749
Polyphyllin D punctures hypertrophic lysosomes to reverse drug resistance of hepatocellular carcinoma by targeting acid sphingomyelinase.
Wang Y, Chen YY, Gao GB, Zheng YH, Yu NN, Ouyang L, Gao X, Li N, Wen SY, Huang S, Zhao Q, Liu L, Cao M, Zhang S, Zhang J, He QY
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Jul 5;31(7):2169-2187
Molecular therapy : the journal of the American Society of Gene Therapy 2023 Jul 5;31(7):2169-2187
Disrupted in renal carcinoma 2 (DIRC2/SLC49A4) is an H(+)-driven lysosomal pyridoxine exporter.
Akino S, Yasujima T, Yamashiro T, Yuasa H
Life science alliance 2023 Feb;6(2)
Life science alliance 2023 Feb;6(2)
Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.
Huang KC, Chiang YF, Huang TC, Chen HY, Lin PH, Ali M, Hsia SM
Journal of cachexia, sarcopenia and muscle 2023 Feb;14(1):182-197
Journal of cachexia, sarcopenia and muscle 2023 Feb;14(1):182-197
Mitophagy bridges DNA sensing with metabolic adaption to expand lung cancer stem-like cells.
Liu Z, Shan S, Yuan Z, Wu F, Zheng M, Wang Y, Gui J, Xu W, Wang C, Ren T, Wen Z
EMBO reports 2023 Feb 6;24(2):e54006
EMBO reports 2023 Feb 6;24(2):e54006
PNPLA2 mobilizes retinyl esters from retinosomes and promotes the generation of 11-cis-retinal in the visual cycle.
Hara M, Wu W, Malechka VV, Takahashi Y, Ma JX, Moiseyev G
Cell reports 2023 Feb 28;42(2):112091
Cell reports 2023 Feb 28;42(2):112091
Serine hydroxymethyltransferase 2 knockdown induces apoptosis in ccRCC by causing lysosomal membrane permeabilization via metabolic reprogramming.
Liu Z, Fan M, Hou J, Pan S, Xu Y, Zhang H, Liu C, Hao X, Li X, Wang H
Cell death & disease 2023 Feb 20;14(2):144
Cell death & disease 2023 Feb 20;14(2):144
LAMP3 transfer via extracellular particles induces apoptosis in Sjögren's disease.
Tanaka T, Nakamura H, Tran DT, Warner BM, Wang Y, Atsumi T, Noguchi M, Chiorini JA
Scientific reports 2023 Feb 14;13(1):2595
Scientific reports 2023 Feb 14;13(1):2595
A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB.
Lin Y, Shi Q, Yang G, Shi F, Zhou Y, Wang T, Xu P, Li P, Liu Z, Sun H, Zhao Z, Ding K, Wang Z, Feng H, Yu B, Fang P, Wang J
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 14;120(7):e2213670120
Proceedings of the National Academy of Sciences of the United States of America 2023 Feb 14;120(7):e2213670120
Lonicerae flos polysaccharides improve nonalcoholic fatty liver disease by activating the adenosine 5'-monophosphate-activated protein kinase pathway and reshaping gut microbiota.
Han C, Li Z, Liu R, Zhao Z, Wang Y, Zuo X, Zhang Y, Geng Z, Huang H, Pan X, Li W
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Journal of the science of food and agriculture 2023 Dec;103(15):7721-7738
Inhibition of CK2/ING4 Pathway Facilitates Non-Small Cell Lung Cancer Immunotherapy.
Gou Q, Chen H, Chen M, Shi J, Jin J, Liu Q, Hou Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2304068
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(34):e2304068
DR region of NKAα1 is a target to ameliorate hepatic lipid metabolism disturbance in obese mice.
Sun HJ, Tan JX, Shan XD, Wang ZC, Wu ZY, Bian JS, Nie XW
Metabolism: clinical and experimental 2023 Aug;145:155579
Metabolism: clinical and experimental 2023 Aug;145:155579
FOXP3+ macrophage represses acute ischemic stroke-induced neural inflammation.
Cai W, Hu M, Li C, Wu R, Lu D, Xie C, Zhang W, Li T, Shen S, Huang H, Qiu W, Liu Q, Lu Y, Lu Z
Autophagy 2023 Apr;19(4):1144-1163
Autophagy 2023 Apr;19(4):1144-1163
PRKX down-regulates TAK1/IRF7 signaling in the antiviral innate immunity of black carp Mylopharyngodon piceus.
Yang X, Ai Y, Chen L, Wang C, Liu J, Zhang J, Li J, Wu H, Xiao J, Chang M, Feng H
Frontiers in immunology 2022;13:999219
Frontiers in immunology 2022;13:999219
TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication.
Yan F, Yang W, Wang X, Gao G
Journal of virology 2022 Sep 14;96(17):e0091922
Journal of virology 2022 Sep 14;96(17):e0091922
Berbamine hydrochloride inhibits bovine viral diarrhea virus replication via interfering in late-stage autophagy.
Wang J, Yang G, Zhang L, Zhang J, Wang J, Zou Y, Wang J
Virus research 2022 Nov;321:198905
Virus research 2022 Nov;321:198905
Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease.
Liu J, Li D, Dun Y, Li H, Ripley-Gonzalez JW, Zhang J, Qiu L, You B, Liu S
Life sciences 2022 Nov 1;308:120949
Life sciences 2022 Nov 1;308:120949
SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells.
Zhao Y, Mao A, Zhang R, Guan S, Lu J
Environmental toxicology 2022 Mar;37(3):549-563
Environmental toxicology 2022 Mar;37(3):549-563
Thioredoxin interacting protein protects mice from fasting induced liver steatosis by activating ER stress and its downstream signaling pathways.
Miyahara H, Hasegawa K, Yashiro M, Ohara T, Fujisawa M, Yoshimura T, Matsukawa A, Tsukahara H
Scientific reports 2022 Mar 21;12(1):4819
Scientific reports 2022 Mar 21;12(1):4819
Compensatory engulfment and Müller glia reactivity in the absence of microglia.
Thiel WA, Blume ZI, Mitchell DM
Glia 2022 Jul;70(7):1402-1425
Glia 2022 Jul;70(7):1402-1425
LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.
Tanaka T, Warner BM, Michael DG, Nakamura H, Odani T, Yin H, Atsumi T, Noguchi M, Chiorini JA
Autophagy 2022 Jul;18(7):1629-1647
Autophagy 2022 Jul;18(7):1629-1647
Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice.
Ma C, Wu H, Yang G, Xiang J, Feng K, Zhang J, Hua Y, Kang L, Fan G, Yang S
British journal of pharmacology 2022 Jan;179(2):252-269
British journal of pharmacology 2022 Jan;179(2):252-269
A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation.
Aring L, Choi EK, Kopera H, Lanigan T, Iwase S, Klionsky DJ, Seo YA
Journal of neurochemistry 2022 Feb;160(3):356-375
Journal of neurochemistry 2022 Feb;160(3):356-375
Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.
Kang Y, Yin S, Liu J, Jiang Y, Huang Z, Chen L, Shao L
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
GRN-/- iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis.
Bossolasco P, Cimini S, Maderna E, Bardelli D, Canafoglia L, Cavallaro T, Ricci M, Silani V, Marucci G, Rossi G
Neurobiology of disease 2022 Dec;175:105891
Neurobiology of disease 2022 Dec;175:105891
Sulforaphane Ameliorates Hepatic Lipid Metabolism via Modulating Lipophagy In Vivo and In Vitro.
Lei P, Hu Y, Gao P, Ding Q, Yan J, Zhao J, Li B, Shan Y
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15126-15133
Journal of agricultural and food chemistry 2022 Dec 7;70(48):15126-15133
Multi-omics analysis unravels dysregulated lysosomal function and lipid metabolism involved in sub-chronic particulate matter-induced pulmonary injury.
Yan L, Chen S, Hou C, Lin J, Xiong W, Shen Y, Zhou T
The Science of the total environment 2022 Aug 25;836:155642
The Science of the total environment 2022 Aug 25;836:155642
The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy.
Zhang G, Han J, Wang L, Yang X, Yan Z, Qu M, Zhou H, Bilal H, Wang F, Ge H, Yang X
iScience 2022 Apr 15;25(4):104085
iScience 2022 Apr 15;25(4):104085
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Jin C, Ou Q, Chen J, Wang T, Zhang J, Wang Z, Wang Y, Tian H, Xu JY, Gao F, Wang J, Li J, Lu L, Xu GT
Stem cell research & therapy 2022 Apr 1;13(1):136
Stem cell research & therapy 2022 Apr 1;13(1):136
WDR45 Mutation Impairs the Autophagic Degradation of Transferrin Receptor and Promotes Ferroptosis.
Xiong Q, Li X, Li W, Chen G, Xiao H, Li P, Wu C
Frontiers in molecular biosciences 2021;8:645831
Frontiers in molecular biosciences 2021;8:645831
Molecular Characterization of AMPA-Receptor-Containing Vesicles.
Peters JJ, Leitz J, Oses-Prieto JA, Burlingame AL, Brunger AT
Frontiers in molecular neuroscience 2021;14:754631
Frontiers in molecular neuroscience 2021;14:754631
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Chu BX, Li YN, Liu N, Yuan LX, Chen SY, Zhu YH, Wang JF
Frontiers in immunology 2021;12:757909
Frontiers in immunology 2021;12:757909
Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia.
Yu P, Li Y, Zhong G, Li W, Chen B, Zhang J
Frontiers in physiology 2021;12:737474
Frontiers in physiology 2021;12:737474
TFEB Promotes Prostate Cancer Progression via Regulating ABCA2-Dependent Lysosomal Biogenesis.
Zhu X, Zhuo Y, Wu S, Chen Y, Ye J, Deng Y, Feng Y, Liu R, Cai S, Zou Z, Wang B, Wu CL, Zeng G, Zhong W
Frontiers in oncology 2021;11:632524
Frontiers in oncology 2021;11:632524
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Wang S, Xu X, Che D, Fan R, Gao M, Cao Y, Ge C, Feng Y, Li J, Xie S, Wang C, Dai F, Gao L, Wang Y
International journal of molecular sciences 2021 Oct 12;22(20)
International journal of molecular sciences 2021 Oct 12;22(20)
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Archives of pharmacal research 2021 Nov;44(11):1025-1036
1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT/mTOR/FOXO1 pathway in mice.
Fan Y, Lu J, Liu J, Zhang R, Yu Z, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Nov;157:112578
Mismatch repair deficiency predicts response to HER2 blockade in HER2-negative breast cancer.
Punturi NB, Seker S, Devarakonda V, Mazumder A, Kalra R, Chen CH, Li S, Primeau T, Ellis MJ, Kavuri SM, Haricharan S
Nature communications 2021 May 19;12(1):2940
Nature communications 2021 May 19;12(1):2940
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Li H, Dun Y, Zhang W, You B, Liu Y, Fu S, Qiu L, Cheng J, Ripley-Gonzalez JW, Liu S
Life sciences 2021 May 15;273:119314
Life sciences 2021 May 15;273:119314
GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice.
Yuan W, Lu L, Rao M, Huang Y, Liu CE, Liu S, Zhao Y, Liu H, Zhu J, Chao T, Wu C, Ren J, Lv L, Li W, Qi S, Liang Y, Yue S, Gao J, Zhang Z, Kong E
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 30;118(13)
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 30;118(13)
Thioxothiazolidin derivative, 4-OST, inhibits melanogenesis by enhancing the specific recruitment of tyrosinase-containing vesicles to lysosome.
Isogawa K, Asano M, Hayazaki M, Koga K, Watanabe M, Suzuki K, Kobayashi T, Kawaguchi K, Ishizuka A, Kato S, Ito H, Hamamoto A, Koyama H, Furuta K, Takemori H
Journal of cellular biochemistry 2021 Jun;122(6):667-678
Journal of cellular biochemistry 2021 Jun;122(6):667-678
Circ_0030998 promotes tumor proliferation and angiogenesis by sponging miR-567 to regulate VEGFA in colorectal cancer.
Jin L, Han C, Zhai T, Zhang X, Chen C, Lian L
Cell death discovery 2021 Jun 24;7(1):160
Cell death discovery 2021 Jun 24;7(1):160
Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE(-/-) mice.
Wu H, Feng K, Zhang C, Zhang H, Zhang J, Hua Y, Dong Z, Zhu Y, Yang S, Ma C
Biochemical and biophysical research communications 2021 Jun 11;557:334-341
Biochemical and biophysical research communications 2021 Jun 11;557:334-341
Asparagine endopeptidase cleaves synaptojanin 1 and triggers synaptic dysfunction in Parkinson's disease.
Zou L, Zhang X, Xiong M, Meng L, Tian Y, Pan L, Yuan X, Chen G, Wang Z, Bu L, Yao Z, Zhang Z, Ye K, Zhang Z
Neurobiology of disease 2021 Jul;154:105326
Neurobiology of disease 2021 Jul;154:105326
Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.
Wang R, Zhu Y, Ren C, Yang S, Tian S, Chen H, Jin M, Zhou H
Autophagy 2021 Feb;17(2):496-511
Autophagy 2021 Feb;17(2):496-511
Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation.
Zhang Z, Mou Z, Xu C, Wu S, Dai X, Chen X, Ou Y, Chen Y, Yang C, Jiang H
Cell death & disease 2021 Aug 7;12(8):778
Cell death & disease 2021 Aug 7;12(8):778
Identification of Compound CB-2 as a Novel Late-Stage Autophagy Inhibitor Exhibits Inhibitory Potency against A549 Cells.
Liu Z, Zhang L, Liu Y, Zhang H, Chen J, Feng G, Yang P, Sha F, Cui L, Sun G
Life (Basel, Switzerland) 2021 Aug 23;11(8)
Life (Basel, Switzerland) 2021 Aug 23;11(8)
1,3-dichloro-2-propanol induced lipid accumulation by blocking autophagy flux in HepG2 cells.
Lu J, Fan Y, Liu M, Zhang Q, Guan S
Toxicology 2021 Apr 30;454:152716
Toxicology 2021 Apr 30;454:152716
Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells.
Ko EJ, Ock MS, Choi YH, Iovanna JL, Mun S, Han K, Kim HS, Cha HJ
International journal of molecular sciences 2021 Apr 11;22(8)
International journal of molecular sciences 2021 Apr 11;22(8)
Meg3 Induces EMT and Invasion of Glioma Cells via Autophagy.
Yang Z, Bian E, Xu Y, Ji X, Tang F, Ma C, Wang H, Zhao B
OncoTargets and therapy 2020;13:989-1000
OncoTargets and therapy 2020;13:989-1000
The Late Domain of Prototype Foamy Virus Gag Facilitates Autophagic Clearance of Stress Granules by Promoting Amphisome Formation.
Zheng Y, Zhu G, Yan J, Tang Y, Han S, Yin J, Peng B, He X, Liu W
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.
Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W
Aging cell 2020 Jun;19(6):e13163
Aging cell 2020 Jun;19(6):e13163
Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.
Tang D, Liu X, Chen K, Li Z, Dai Y, Xu J, Zhang HT, Gao X, Liu L
Aging 2020 Jun 27;12(13):13297-13317
Aging 2020 Jun 27;12(13):13297-13317
mTORC1-dependent TFEB nucleus translocation and pro-survival autophagy induced by zeolitic imidazolate framework-8.
Ding H, Song Y, Huang X, Wang L, Luo S, Zhang H, Pan H, Jiang W, Qian J, Yao G, Wen L, Zhang Y
Biomaterials science 2020 Jul 28;8(15):4358-4369
Biomaterials science 2020 Jul 28;8(15):4358-4369
The N-glycosylation of Equine Tetherin Affects Antiviral Activity by Regulating Its Subcellular Localization.
Bai B, Wang XF, Zhang M, Na L, Zhang X, Zhang H, Yang Z, Wang X
Viruses 2020 Feb 16;12(2)
Viruses 2020 Feb 16;12(2)
An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice.
Lu W, Tian H, Qian P, Li Y, Wang Y, Ge Y, Sai W, Gao X, Yao W
British journal of pharmacology 2020 Aug;177(15):3473-3488
British journal of pharmacology 2020 Aug;177(15):3473-3488
Butyrate-mediated autophagy inhibition limits cytosolic Salmonella Infantis replication in the colon of pigs treated with a mixture of Lactobacillus and Bacillus.
Chu B, Zhu Y, Su J, Xia B, Zou Y, Nie J, Zhang W, Wang J
Veterinary research 2020 Aug 5;51(1):99
Veterinary research 2020 Aug 5;51(1):99
Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes.
Wu X, Sun R, Wang H, Yang B, Wang F, Xu H, Chen S, Zhao R, Pi J, Xu Y
Oxidative medicine and cellular longevity 2019;2019:1038932
Oxidative medicine and cellular longevity 2019;2019:1038932
LncRNA expression profile during autophagy and Malat1 function in macrophages.
Ma Z, Zhang J, Xu X, Qu Y, Dong H, Dang J, Huo Z, Xu G
PloS one 2019;14(8):e0221104
PloS one 2019;14(8):e0221104
Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease.
Del Grosso A, Angella L, Tonazzini I, Moscardini A, Giordano N, Caleo M, Rocchiccioli S, Cecchini M
Neurobiology of disease 2019 Sep;129:195-207
Neurobiology of disease 2019 Sep;129:195-207
Pyrroloquinoline quinine ameliorates doxorubicin-induced autophagy-dependent apoptosis via lysosomal-mitochondrial axis in vascular endothelial cells.
Jiang C, Jiang L, Li Q, Liu X, Zhang T, Yang G, Zhang C, Wang N, Sun X, Jiang L
Toxicology 2019 Sep 1;425:152238
Toxicology 2019 Sep 1;425:152238
Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.
Sheng J, Shen L, Sun L, Zhang X, Cui R, Wang L
Cell proliferation 2019 May;52(3):e12609
Cell proliferation 2019 May;52(3):e12609
Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy.
Hussain T, Zhao D, Shah SZA, Sabir N, Wang J, Liao Y, Song Y, Dong H, Hussain Mangi M, Ni J, Yang L, Zhou X
Cells 2019 May 26;8(5)
Cells 2019 May 26;8(5)
Identification and functional characterization of interferon-γ-inducible lysosomal thiol reductase (GILT) gene in common Chinese cuttlefish Sepiella japonica.
Pang Z, Zhang Y, Liu L
Fish & shellfish immunology 2019 Mar;86:627-634
Fish & shellfish immunology 2019 Mar;86:627-634
Circular RNA profiling provides insights into their subcellular distribution and molecular characteristics in HepG2 cells.
Zhang J, Zhang X, Li C, Yue L, Ding N, Riordan T, Yang L, Li Y, Jen C, Lin S, Zhou D, Chen F
RNA biology 2019 Feb;16(2):220-232
RNA biology 2019 Feb;16(2):220-232
Autophagy Attenuates Angiotensin II-Induced Pulmonary Fibrosis by Inhibiting Redox Imbalance-Mediated NOD-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation.
Meng Y, Pan M, Zheng B, Chen Y, Li W, Yang Q, Zheng Z, Sun N, Zhang Y, Li X
Antioxidants & redox signaling 2019 Feb 1;30(4):520-541
Antioxidants & redox signaling 2019 Feb 1;30(4):520-541
Sufentanil impairs autophagic degradation and inhibits cell migration in NCI-H460 in vitro.
Jiang H, Wang H, Zou W, Hu Y, Chen C, Wang C
Oncology letters 2019 Dec;18(6):6829-6835
Oncology letters 2019 Dec;18(6):6829-6835
Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.
Xu Z, Zhang Y, Zhang S, Jia X, Zhong G, Yang Y, Du Q, Li J, Liu Z
Cancer letters 2019 Apr 10;447:75-85
Cancer letters 2019 Apr 10;447:75-85
Acetyl-CoA Synthetase 2 Promotes Cell Migration and Invasion of Renal Cell Carcinoma by Upregulating Lysosomal-Associated Membrane Protein 1 Expression.
Yao L, Guo X, Gui Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(3):984-992
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(3):984-992
Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction.
Ren Y, Chen J, Wu X, Gui C, Mao K, Zou F, Li W
Toxicological sciences : an official journal of the Society of Toxicology 2018 Sep 1;165(1):232-243
Toxicological sciences : an official journal of the Society of Toxicology 2018 Sep 1;165(1):232-243
The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.
Deng M, Tang Y, Li W, Wang X, Zhang R, Zhang X, Zhao X, Liu J, Tang C, Liu Z, Huang Y, Peng H, Xiao L, Tang D, Scott MJ, Wang Q, Liu J, Xiao X, Watkins S, Li J, Yang H, Wang H, Chen F, Tracey KJ, Billiar TR, Lu B
Immunity 2018 Oct 16;49(4):740-753.e7
Immunity 2018 Oct 16;49(4):740-753.e7
Differential signaling pathways are initiated in macrophages during infection depending on the intracellular fate of Chlamydia spp.
Nagarajan UM, Tripathy M, Kollipara A, Allen J 4th, Goodwin A, Whittimore J, Wyrick PB, Rank RG
Immunology and cell biology 2018 Mar;96(3):246-256
Immunology and cell biology 2018 Mar;96(3):246-256
LIN28A inhibits lysosome‑associated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells.
Pan P, Chen T, Zhang Y, Qi Z, Qin J, Cui G, Guo X
Molecular medicine reports 2018 Jul;18(1):399-406
Molecular medicine reports 2018 Jul;18(1):399-406
Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions.
Yu Z, Ma J, Li X, Liu Y, Li M, Wang L, Zhao M, He H, Zhang Y, Rao Q, Zhao D, Wang Y, Fan L, Li P, Liu Y, Liu F, Zhang F, Ye J, Yan Q, Guo S, Wang Z
Scientific reports 2018 Jul 2;8(1):9972
Scientific reports 2018 Jul 2;8(1):9972
Molecular and biological characterization of gamma-interferon-inducible lysosomal thiol reductase in silver carp (Hypophthalmichthys molitrix).
Cao F, Wu H, Lv T, Yang Y, Li Y, Liu S, Hu L, Xu X, Ma L, Zhang X, Li J, Bi X, Gu W, Zhang S
Fish & shellfish immunology 2018 Aug;79:73-78
Fish & shellfish immunology 2018 Aug;79:73-78
Entosis Acts as a Novel Way within Sertoli Cells to Eliminate Spermatozoa in Seminiferous Tubule.
Ahmed N, Yang P, Huang Y, Chen H, Liu T, Wang L, Nabi F, Liu Y, Chen Q
Frontiers in physiology 2017;8:361
Frontiers in physiology 2017;8:361
Upregulation of the lncRNA Meg3 induces autophagy to inhibit tumorigenesis and progression of epithelial ovarian carcinoma by regulating activity of ATG3.
Xiu YL, Sun KX, Chen X, Chen S, Zhao Y, Guo QG, Zong ZH
Oncotarget 2017 May 9;8(19):31714-31725
Oncotarget 2017 May 9;8(19):31714-31725
Altered expression of lysosomal associated membrane protein 1 in esophageal squamous cell carcinoma.
Huang J, Li L, Liu J, Yu J, Wu X, Xu Y, Ma M, Wang W, Zhang R
Pathology, research and practice 2017 Aug;213(8):938-942
Pathology, research and practice 2017 Aug;213(8):938-942
Identification and characterization of an endoplasmic reticulum localization motif.
Nie YW, Wang M, Zhang P, Huan L, Liu DJ
Biochemical and biophysical research communications 2016 Apr 22;473(1):249-254
Biochemical and biophysical research communications 2016 Apr 22;473(1):249-254
Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV).
Zhou N, Pan T, Zhang J, Li Q, Zhang X, Bai C, Huang F, Peng T, Zhang J, Liu C, Tao L, Zhang H
The Journal of biological chemistry 2016 Apr 22;291(17):9218-32
The Journal of biological chemistry 2016 Apr 22;291(17):9218-32
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- Main image
- Experimental details
- RAW 264.7 cells were subjected to SDS PAGE followed by western blot with 21997-1-AP( CD107a Antibody) at dilution of 1:2000
- Other comments
- WB
