67300-1-Ig

antibody from Proteintech Group

Targeting: LAMP1 CD107a

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

67300-1-Ig

Provider

Proteintech Group

Product name

CD107a antibody

Antibody type

Monoclonal

Description

CD107a antibody (Cat. #67300-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB, ELISA.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3B2E9

Vial size

20ul, 150ul

References

Submitted references

Escitalopram accelerated aging via impaired IIS/autophagy signaling pathway.

Chen ZY, Qi CY, Feng J, Xue K, Quan HB, Zhou J, Liu WZ, Lu GD
GeroScience 2026 Mar 5;

---

NPC2 suppresses osteolytic metastasis in lung adenocarcinoma via the AKT/mTOR pathway and tumor-osteoclast crosstalk.

Zhou S, Li N, Li R, Ding Y, Zhu Y, Pan Y, Liu Y, Zhang Y, Yang H, Wang Q
iScience 2026 Mar 20;29(3):115017

---

ACE2 mitigates Streptococcus uberis-induced ferroptosis in goat mammary epithelial cells by inhibiting ROS-chaperone-mediated autophagic degradation of GPX4.

Wu G, Ma C, Xu J, Chen X, Chen X, Wang G, Zhang Y
Microbial pathogenesis 2026 Jan;210:108141

---

Ubiquitination degradation of GATA4 by CUL4B promotes ovarian cancer metastasis by inducing lysosomal acidification.

Yin X, Gao R, Geng Y, Mu X, Zhang Y, Ma Y, Chen X, Han F, Chen Z, Li F, He J
Genome biology 2026 Feb 9;27(1)

---

Disruption of FGL2 induces TFEB-dependent lysosomal degradation of PD-L1 and enhances the efficacy of anti-PD1 therapy in hepatocellular carcinoma.

Han M, Guan Q, Yan F, Wang M, Xi D, Ning Q
Cell communication and signaling : CCS 2026 Feb 2;24(1)

---

Stabilizing MARCH7 as a ferro-guardian against ferroptosis.

Huang W, Wang R, Yang X, Yang S, Yang X, He G, Dai S, Li C, Gao L, Zhang T, Zhang P, Chen R, Zheng K, Wu J, Min J, Ba Q, Wang F, Zhang Q
Cell 2026 Apr 27;

---

Fenofibrate suppresses Mycoplasma bovis infection via autophagy-mediated cholesterol regulation in bovine mammary epithelial cells and murine mammary tissue.

Xu M, Wang T, Deng X, Liu Y, Zhu Z, Barkema HW, Cobo ER, Kastelic JP, Zhou X, Han B
Frontiers in cellular and infection microbiology 2025;15:1731492

---

Histone lactylation exacerbates acute lung injury in septic mice by promoting ferroptosis in pulmonary microvascular endothelial cells.

Fang P, Li S, Lu ZQ, Xia DL, Xu MM, Pan JJ, Fu L, Sun GY, You QH
Burns & trauma 2025;13:tkaf056

---

Phillygenin ameliorates myocardial ischemia-reperfusion injury by inhibiting cuproptosis via the autophagy-lysosome degradation of CTR1.

Chen G, Wei M, Zhao CY, Zhang AY, Su JB, Ni ZR, Cai WW, Hou B, Du B, Liu MH, Xu GW, Yang L, Xu AJ, Wen YY, Wang J, Zou H, Zhuang YY, Xing HY, He T, Li YF, Lu QB, Zhu J, Zhu XX, Li KL, Sun HJ
Free radical biology & medicine 2025 Sep;237:542-557

---

SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.

Yaxian L, Xiaodong W, Futao M, Huizhen W, Chuansheng W, Mengdi M, Bo Y, Yida L, Xin X, Ziqing F, Mingdian L, Yuxian S, Yongxiang L
International journal of biological macromolecules 2025 Oct;327(Pt 1):147188

---

Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca(2+) Crosstalk at Lysosome-ER MCSs Leading to Lethal Depleting of ER Calcium.

Zhu MY, Guo YJ, Zhu YQ, Wang HZ, Wang HD, Chen HY, Jiang YX, Li H, Hui H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e15313

---

Platycodin D attenuates diabetic renal ischemia/reperfusion injury by enhancing mitophagy and suppressing MAPK/NF-κB signaling activation.

Qin X, Liu J, Zhao X, Wang L, Liu X, Chen Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Nov;1871(8):168026

---

Syntaxin-6 restricts SARS-CoV-2 infection by facilitating virus trafficking to autophagosomes.

Sun H, Yang Q, Zhang Y, Cui S, Zhou Z, Zhang P, Jia L, Zhang M, Wang Y, Chen X, Pei R
Journal of virology 2025 May 20;99(5):e0000225

---

A Bifunctional Lysosome-Targeting Chimera Nanoplatform for Tumor-Selective Protein Degradation and Enhanced Cancer Immunotherapy.

Xing Y, Li J, Wang L, Zhu Z, Yan J, Liu Y, Liu Q
Advanced materials (Deerfield Beach, Fla.) 2025 Mar;37(10):e2417942

---

Lysophosphatidylcholine promoting α-Synuclein aggregation in Parkinson's disease: disrupting GCase glycosylation and lysosomal α-Synuclein degradation.

Mu C, Shao K, Su M, Guo Y, Qiu Y, Sun R, Sun S, Sun Y, Liu C, Wang W, Qin X, Tang C
NPJ Parkinson's disease 2025 Mar 15;11(1):47

---

OSBP Participates in Neural Damage Repair by Regulating Lysosome Transport Under Oxidative Stress.

Fei M, Luo S, Gao C, Huang X, Wang L, Jin T, Liu M, Zhou M, Wang H
Molecular neurobiology 2025 Jun;62(6):7557-7575

---

Astragalin-functionalized ultrasmall nanoparticles modulate the complement pathway to inhibit microglial synaptic phagocytosis for reducing anesthetic neurotoxicity.

Wang G, Han Y, Peng K, Jiang Z, Wang T, Zheng Q, Li W, Xu H, Ji F, Li Z
Materials today. Bio 2025 Jun;32:101714

---

The SGLT2 inhibitor dapagliflozin suppresses endothelial cell pyroptosis mediated by the NF-κB/NLRP3 pathway through downregulation of CTSB.

Zhao Q, Li H, Liu D, Zhou B, Gong C, Chen L, Liao F
Biochemical pharmacology 2025 Jun;236:116857

---

Mycobacterium bovis Mb3523c protein regulates host ferroptosis via chaperone-mediated autophagy.

Wang H, Liu D, Ge X, Wang Y, Zhou X
Autophagy 2025 Jun;21(6):1335-1352

---

IFITM proteins are key entry factors for porcine epidemic diarrhea coronavirus.

Lv L, Luo H, Yi J, Zhang K, Li Y, Tong W, Jiang Y, Zhou Y, Tong G, Liu C
Journal of virology 2025 Jun 17;99(6):e0202824

---

Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.

Cheng Z, Gao H, Shi P, Zhang A, Chen X, Chen Y, Gan W, Zhao K, Li S, Yang C, Zhang Y
Bone research 2025 Jun 12;13(1):62

---

Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health.

Nemoto S, Uchida K, Kubota T, Nakayama M, Han YW, Koyasu S, Ohno H
Molecular metabolism 2025 Jul;97:102168

---

Transglutaminase 2 promotes breast cancer cell autophagy by targeting p53/ mTOR axis.

Chen J, Li M, Mao J, Wang X, Guo B, Chen X, Kalvakolanu DV, Hong J, Yang M, Liu J, Luo Q, Yang J, Sun X, Tian Y, Zhang L
Biochemical pharmacology 2025 Jul;237:116926

---

Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degeneration.

Tang Q, Tang K, Markby GR, Parys M, Phadwal K, MacRae VE, Corcoran BM
Autophagy 2025 Jul;21(7):1433-1455

---

TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4.

He Z, Zheng D, Li F, Chen L, Wu C, Zeng Z, Yu C
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jan;78:101171

---

Itaconic acid ameliorates necrotizing enterocolitis through the TFEB-mediated autophagy-lysosomal pathway.

Chen B, Liu Y, Luo S, Zhou J, Wang Y, He Q, Zhuang G, Hao H, Ma F, Xiao X, Li S
Free radical biology & medicine 2025 Jan;226:251-265

---

TMEM106B knockdown exhibits a neuroprotective effect in Parkinson's disease models via regulating autophagy-lysosome pathway.

Liu Y, Qin K, Dou K, Ren J, Hou B, Xie A
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167553

---

Polymeric Polylactic Acid-Glycolic Acid-Based Nanoparticles Deliver Nintedanib Across the Blood-Brain Barrier to Inhibit Glioblastoma Growth.

Dang Y, Zhao Z, Wang B, Du A, Li S, Yuan G, Pan Y
International journal of molecular sciences 2025 Jan 7;26(2)

---

Cleaving PINK1 or PGAM5? Involvement of PARL in Methamphetamine-Induced Excessive Mitophagy and Neuronal Necroptosis.

An D, Zhang C, Zhou P, Wang Y, Meng S, Chen Y, Xu W, Xuan J, Xiong J, Cheng J, Gao R, Wang J, Chen X
CNS neuroscience & therapeutics 2025 Feb;31(2):e70293

---

Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4.

Zhu XX, Su JB, Wang FM, Chai XY, Chen G, Xu AJ, Meng XY, Qiu HB, Sun QY, Wang Y, Lv ZL, Zhang Y, Liu Y, Han ZJ, Li N, Sun HJ, Lu QB
Clinical and translational medicine 2025 Feb;15(2):e70221

---

In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux.

Lv Y, Song B, Yang G, Wang Y, Wu Z, Si M, Yang Z, Chen H, Liu C, Li M, Zhang Y, Qiao Z, Wang L, Xu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2409425

---

The tryptophan-aspartate (WD) repeat domain of bovine Coronin-1A promotes mycobacterial survival by inhibiting calcium signaling-mediated phagosome-lysosome fusion.

Yang J, Li Z, Li A, Liu Y, Zhang X, Zhang Y, Gao Y
Veterinary research 2025 Feb 7;56(1):33

---

LAPTM5 confers cisplatin resistance in NSCLC by suppressing LAMP1 ubiquitination to stabilize lysosomal membranes and sustain autophagic flux.

Wu F, Li C, Song X, Xie L
Cellular signalling 2025 Aug;132:111834

---

Quercetin alleviates LPS/iE-DAP-induced liver injury by suppressing ferroptosis via regulating ferritinophagy and intracellular iron efflux.

Zhang H, Shi H, Li X, Zhou S, Song X, Ma N, Meng M, Chang G, Shen X
Redox biology 2025 Apr;81:103557

---

Annexin A5 Derived from Cell-free Fat Extract Attenuates Osteoarthritis via Macrophage Regulation.

Jia Z, Kang B, Dong Y, Fan M, Li W, Zhang W
International journal of biological sciences 2024;20(8):2994-3007

---

Caveolin Regulates the Transport Mechanism of the Walnut-Derived Peptide EVSGPGYSPN to Penetrate the Blood-Brain Barrier.

Li Z, Dang Q, Liu C, Liu Y, Wang C, Zhao F, Wang Q, Min W
Journal of agricultural and food chemistry 2024 Sep 11;72(36):19786-19799

---

TMEM232 is required for the formation of sperm flagellum and male fertility in mice.

Cai X, Zhang H, Kong S, Xu W, Zheng J, Wang N, He S, Li S, Shen Y, Wang K, Zhang Z, Cai H, Ma F, Bai S, Zhu F, Xiao F, Wang F
Cell death & disease 2024 Nov 8;15(11):806

---

Iron regulatory protein 2 contributes to antimicrobial immunity by preserving lysosomal function in macrophages.

Cheng C, Xing Z, Zhang W, Zheng L, Zhao H, Zhang X, Ding Y, Qiao T, Li Y, Meyron-Holtz EG, Missirlis F, Fan Z, Li K
Proceedings of the National Academy of Sciences of the United States of America 2024 Jul 30;121(31):e2321929121

---

Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin.

Mao B, Le-Trilling VTK, Tang H, Hu J, Schmitz MS, Barbet K, Xu D, Wei Z, Guo B, Mennerich D, Yao C, Liu J, Li Z, Wan Y, Zhang X, Wang K, Tang N, Yu Z, Trilling M, Lin Y
Virus research 2024 Dec;350:199485

---

Atg5-deficient mesenchymal stem cells protect against non-alcoholic fatty liver by accelerating hepatocyte growth factor secretion.

Zhang C, Ji J, Du X, Zhang L, Song Y, Wang Y, Jiang Y, Li K, Chang T
Cell communication and signaling : CCS 2024 Dec 3;22(1):579

---

miR-29b-1-5p exacerbates myocardial injury induced by sepsis in a mouse model by targeting TERF2.

Jiang Y, Xu J, Zeng H, Lin Z, Yi Q, Guo J, Xiao F
Acta biochimica et biophysica Sinica 2024 Apr 25;56(4):607-620

---

A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.

Chen J, Feng D, Lu Y, Zhang Y, Jiang H, Yuan M, Xu Y, Zou J, Zhu Y, Zhang J, Ge C, Wang Y
Cancers 2023 Mar 5;15(5)

---

Stimulation of Hepatic Ferritinophagy Mitigates Irp2 Depletion-Induced Anemia.

Liu Y, Li Y, Yang L, Shen J, Zhao H, Dong W, Chang Y, Qiao T, Li K
Antioxidants (Basel, Switzerland) 2023 Feb 24;12(3)

---

Leucine-rich repeat kinase 2 (LRRK2) inhibition upregulates microtubule-associated protein 1B to ameliorate lysosomal dysfunction and parkinsonism.

Chen K, Tang F, Du B, Yue ZZ, Jiao LL, Ding XL, Tuo QZ, Meng J, He SY, Dai L, Lei P, Wei XW
MedComm 2023 Dec;4(6):e429

---

Generation and Characterization of SORT1-Targeted Antibody-Drug Conjugate for the Treatment of SORT1-Positive Breast Tumor.

Zhuang W, Zhang W, Xie L, Wang L, Li Y, Wang Z, Zhang A, Qiu H, Feng J, Zhang B, Hu Y
International journal of molecular sciences 2023 Dec 18;24(24)

---

A novel "prime and pull" strategy mediated by the combination of two dendritic cell-targeting designs induced protective lung tissue-resident memory T cells against H1N1 influenza virus challenge.

Wang Z, He Y, Wang W, Tian Y, Ge C, Jia F, Zhang T, Zhang G, Wang M, Gong J, Huang H, Wang J, Shi C, Yang W, Cao X, Zeng Y, Wang N, Qian A, Jiang Y, Yang G, Wang C
Journal of nanobiotechnology 2023 Dec 13;21(1):479

---

Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapy.

Li L, Zhang M, Li J, Liu T, Bao Q, Li X, Long J, Fu L, Zhang Z, Huang S, Liu Z, Zhang L
Nature communications 2023 Aug 22;14(1):5111

---

RAB20 deficiency promotes the development of silicosis via NLRP3 inflammasome.

Peng Z, Duan M, Zhao K, Tang Y, Liang F
Frontiers in immunology 2022;13:967299