Antibody data
- Antibody Data
- Antigen structure
- References [12]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 14798-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14798-1-AP, RRID:AB_2061854
- Product name
- DDX39B antibody
- Antibody type
- Polyclonal
- Description
- DDX39B antibody (Cat. #14798-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Nuclear export of circular RNA.
The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection.
THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate.
TREX (transcription/export)-NP complex exerts a dual effect on regulating polymerase activity and replication of influenza A virus.
RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma.
Porcine ZC3H11A Is Essential for the Proliferation of Pseudorabies Virus and Porcine Circovirus 2.
DDX39B contributes to the proliferation of colorectal cancer through direct binding to CDK6/CCND1.
The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer.
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide.
ALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export.
The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity.
Ngo LH, Bert AG, Dredge BK, Williams T, Murphy V, Li W, Hamilton WB, Carey KT, Toubia J, Pillman KA, Liu D, Desogus J, Chao JA, Deans AJ, Goodall GJ, Wickramasinghe VO
Nature 2024 Mar;627(8002):212-220
Nature 2024 Mar;627(8002):212-220
The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection.
Tapescu I, Taschuk F, Pokharel SM, Zginnyk O, Ferretti M, Bailer PF, Whig K, Madden EA, Heise MT, Schultz DC, Cherry S
Molecular cell 2023 Nov 16;83(22):4174-4189.e7
Molecular cell 2023 Nov 16;83(22):4174-4189.e7
THOC5 complexes with DDX5, DDX17, and CDK12 to regulate R loop structures and transcription elongation rate.
Polenkowski M, Allister AB, Burbano de Lara S, Pierce A, Geary B, El Bounkari O, Wiehlmann L, Hoffmann A, Whetton AD, Tamura T, Tran DDH
iScience 2023 Jan 20;26(1):105784
iScience 2023 Jan 20;26(1):105784
TREX (transcription/export)-NP complex exerts a dual effect on regulating polymerase activity and replication of influenza A virus.
Zhao L, Liu Q, Huang J, Lu Y, Zhao Y, Ping J
PLoS pathogens 2022 Sep;18(9):e1010835
PLoS pathogens 2022 Sep;18(9):e1010835
RETSAT associates with DDX39B to promote fork restarting and resistance to gemcitabine based chemotherapy in pancreatic ductal adenocarcinoma.
Tu Q, Liu X, Yao X, Li R, Liu G, Jiang H, Li K, Chen Q, Huang X, Chang Q, Xu G, Zhu H, Shi P, Zhao B
Journal of experimental & clinical cancer research : CR 2022 Sep 15;41(1):274
Journal of experimental & clinical cancer research : CR 2022 Sep 15;41(1):274
Porcine ZC3H11A Is Essential for the Proliferation of Pseudorabies Virus and Porcine Circovirus 2.
Yang L, Wang Z, Ouyang H, Zhang Y, Xiao W, Liu Y, Deng J, Li M, Ma L, Qi C, Pang D, Yuan H
ACS infectious diseases 2022 Jun 10;8(6):1179-1190
ACS infectious diseases 2022 Jun 10;8(6):1179-1190
DDX39B contributes to the proliferation of colorectal cancer through direct binding to CDK6/CCND1.
Zhang H, He C, Guo X, Fang Y, Lai Q, Wang X, Pan X, Li H, Qin K, Li A, Liu S, Li Q
Cell death discovery 2022 Jan 19;8(1):30
Cell death discovery 2022 Jan 19;8(1):30
The DDX39B/FUT3/TGFβR-I axis promotes tumor metastasis and EMT in colorectal cancer.
He C, Li A, Lai Q, Ding J, Yan Q, Liu S, Li Q
Cell death & disease 2021 Jan 12;12(1):74
Cell death & disease 2021 Jan 12;12(1):74
NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.
Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9
UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide.
Pérez-Calero C, Bayona-Feliu A, Xue X, Barroso SI, Muñoz S, González-Basallote VM, Sung P, Aguilera A
Genes & development 2020 Jul 1;34(13-14):898-912
Genes & development 2020 Jul 1;34(13-14):898-912
ALS Associated Mutations in Matrin 3 Alter Protein-Protein Interactions and Impede mRNA Nuclear Export.
Boehringer A, Garcia-Mansfield K, Singh G, Bakkar N, Pirrotte P, Bowser R
Scientific reports 2017 Nov 6;7(1):14529
Scientific reports 2017 Nov 6;7(1):14529
The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity.
Thomas M, Lischka P, Müller R, Stamminger T
PloS one 2011;6(7):e22671
PloS one 2011;6(7):e22671
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 14798-1-AP(BAT1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 14798-1-AP(BAT1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The UAP56 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human UAP56. This antibody recognizes human,mouse,rat antigen. The UAP56 antibody has been validated for the following applications: ELISA, WB, IHC analysis.