abx200517

antibody from Abbexa

Targeting: CD300E CD300LE, CLM2, IREM2

Flow cytometry (Recommended by provider)

Antibody Data

Product number

abx200517

Provider

Abbexa

Product name

Immune Receptor Expressed On Myeloid Cells 2 (IREM-2) Antibody (PerCP)

Antibody type

Monoclonal

Description

The UP-H2 monoclonal antibody recognizes human IREM-2 (immune receptor expressed in monocytic derived cells) also known as LMIR6, and unofficially CD300E and CD300LE. It is a member of the CMRF-35 family. This 34 kDa Ig-like containing receptor is an activating receptor and through it’s charged residues in the cytokplasmic domain interacts with ITAM containing adaptor proteins like DAP12. Expression is found exclusively on monocytes and myeloid DC’s. Expression may be transient as differentiation of monocytes leads to down regulation of IREM-2 yet expression is found on mature DCs. It has been also noted that myeloid cell lines such as THP-1 and U937 do not express IREM-2.In vitro addition of UP-H2 antibody either soluble or crosslinked stimulates monocytes.

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

100 tests

Storage

Aliquot and store in the dark at 2°C to 8°C. Avoid exposure to light.