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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [23]
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- Validations
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- Product number
- MA1-10327 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Cytokeratin 18 Monoclonal Antibody (DC-10), FITC
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- This antibody reacts with cytokeratin 18 (45 kDa). Cytokeratins are members of intermediate filaments subfamily of intracellular proteins, represented in epithelial tissues. This antibody will not cross-react with porcine, mouse, rat, hamster, bovine, canine or sheep.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Isotype
- IgG
- Antibody clone number
- DC-10
- Vial size
- 100 µg
- Concentration
- 0.1 mg/mL
- Storage
- 4° C, store in dark, DO NOT FREEZE!
Submitted references A novel mechanism of keratin cytoskeleton organization through casein kinase Iα and FAM83H in colorectal cancer.
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature.
Expression of KRT7 and WT1 differentiates precursor lesions of Wilms' tumours from those of papillary renal cell tumours and mucinous tubular and spindle cell carcinomas.
Directed differentiation of human embryonic stem cells to epidermal progenitors.
Giant clear cell hidradenoma of the knee.
Cytoskeletal keratin glycosylation protects epithelial tissue from injury.
Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates.
Endometrial profile of tamoxifen and low-dose estradiol combination therapy.
Imaging and analysis of 3D tumor spheroids enriched for a cancer stem cell phenotype.
Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines.
Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.
Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation.
An immunohistochemical profile of giant cell carcinoma of the larynx.
Mammary gland development in early pubertal female macaques.
Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease.
Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies.
Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner.
Studying simple epithelial keratins in cells and tissues.
Cytokeratin expression in lichen amyloidosus and macular amyloidosis.
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury.
Keratin 8 mutations in patients with cryptogenic liver disease.
Kuga T, Kume H, Kawasaki N, Sato M, Adachi J, Shiromizu T, Hoshino I, Nishimori T, Matsubara H, Tomonaga T
Journal of cell science 2013 Oct 15;126(Pt 20):4721-31
Journal of cell science 2013 Oct 15;126(Pt 20):4721-31
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.
Snider NT, Leonard JM, Kwan R, Griggs NW, Rui L, Omary MB
The Journal of cell biology 2013 Feb 4;200(3):241-7
The Journal of cell biology 2013 Feb 4;200(3):241-7
Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature.
Marian C, Boila A, Soanca D, Malau M, Podeanu DM, Resetkova E, Stolnicu S
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2013 Apr;121(4):272-9
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2013 Apr;121(4):272-9
Expression of KRT7 and WT1 differentiates precursor lesions of Wilms' tumours from those of papillary renal cell tumours and mucinous tubular and spindle cell carcinomas.
Szponar A, Kovacs G
Virchows Archiv : an international journal of pathology 2012 Apr;460(4):423-7
Virchows Archiv : an international journal of pathology 2012 Apr;460(4):423-7
Directed differentiation of human embryonic stem cells to epidermal progenitors.
Metallo CM, Ji L, de Pablo JJ, Palecek SP
Methods in molecular biology (Clifton, N.J.) 2010;585:83-92
Methods in molecular biology (Clifton, N.J.) 2010;585:83-92
Giant clear cell hidradenoma of the knee.
Yu G, Goodloe S Jr, D'Angelis CA, McGrath BE, Chen F
Journal of cutaneous pathology 2010 Sep;37(9):e37-41
Journal of cutaneous pathology 2010 Sep;37(9):e37-41
Cytoskeletal keratin glycosylation protects epithelial tissue from injury.
Ku NO, Toivola DM, Strnad P, Omary MB
Nature cell biology 2010 Sep;12(9):876-85
Nature cell biology 2010 Sep;12(9):876-85
Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates.
Yalcin-Ozuysal O, Fiche M, Guitierrez M, Wagner KU, Raffoul W, Brisken C
Cell death and differentiation 2010 Oct;17(10):1600-12
Cell death and differentiation 2010 Oct;17(10):1600-12
Endometrial profile of tamoxifen and low-dose estradiol combination therapy.
Wood CE, Kaplan JR, Fontenot MB, Williams JK, Cline JM
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Feb 1;16(3):946-56
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Feb 1;16(3):946-56
Imaging and analysis of 3D tumor spheroids enriched for a cancer stem cell phenotype.
Robertson FM, Ogasawara MA, Ye Z, Chu K, Pickei R, Debeb BG, Woodward WA, Hittelman WN, Cristofanilli M, Barsky SH
Journal of biomolecular screening 2010 Aug;15(7):820-9
Journal of biomolecular screening 2010 Aug;15(7):820-9
Assessment of the tumorigenesis and drug susceptibility of three new canine mammary tumor cell lines.
Chang CY, Chiou PP, Chen WJ, Li YH, Yiu JC, Cheng YH, Chen SD, Lin CT, Lai YS
Research in veterinary science 2010 Apr;88(2):285-93
Research in veterinary science 2010 Apr;88(2):285-93
Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation.
Røsland GV, Svendsen A, Torsvik A, Sobala E, McCormack E, Immervoll H, Mysliwietz J, Tonn JC, Goldbrunner R, Lønning PE, Bjerkvig R, Schichor C
Cancer research 2009 Jul 1;69(13):5331-9
Cancer research 2009 Jul 1;69(13):5331-9
Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation.
Tao GZ, Li DH, Zhou Q, Toivola DM, Strnad P, Sandesara N, Cheung RC, Hong A, Omary MB
The Journal of pathology 2008 Jun;215(2):164-74
The Journal of pathology 2008 Jun;215(2):164-74
An immunohistochemical profile of giant cell carcinoma of the larynx.
Gurbuz Y, Kose N, Aydin O, Ozturk M
Auris, nasus, larynx 2007 Sep;34(3):413-6
Auris, nasus, larynx 2007 Sep;34(3):413-6
Mammary gland development in early pubertal female macaques.
Wood CE, Hester JM, Cline JM
Toxicologic pathology 2007 Oct;35(6):795-805
Toxicologic pathology 2007 Oct;35(6):795-805
Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease.
Tao GZ, Strnad P, Zhou Q, Kamal A, Zhang L, Madani ND, Kugathasan S, Brant SR, Cho JH, Omary MB, Duerr RH
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007 Jul;5(7):857-64
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2007 Jul;5(7):857-64
Bispecific and human disease-related anti-keratin rabbit monoclonal antibodies.
Tao GZ, Nakamichi I, Ku NO, Wang J, Frolkis M, Gong X, Zhu W, Pytela R, Omary MB
Experimental cell research 2006 Feb 15;312(4):411-22
Experimental cell research 2006 Feb 15;312(4):411-22
Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner.
Tao GZ, Toivola DM, Zhou Q, Strnad P, Xu B, Michie SA, Omary MB
Journal of cell science 2006 Apr 1;119(Pt 7):1425-32
Journal of cell science 2006 Apr 1;119(Pt 7):1425-32
Studying simple epithelial keratins in cells and tissues.
Ku NO, Toivola DM, Zhou Q, Tao GZ, Zhong B, Omary MB
Methods in cell biology 2004;78:489-517
Methods in cell biology 2004;78:489-517
Cytokeratin expression in lichen amyloidosus and macular amyloidosis.
Apaydin R, Gürbüz Y, Bayramgürler D, Müezzinoglu B, Bilen N
Journal of the European Academy of Dermatology and Venereology : JEADV 2004 May;18(3):305-9
Journal of the European Academy of Dermatology and Venereology : JEADV 2004 May;18(3):305-9
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease.
Toivola DM, Ku NO, Resurreccion EZ, Nelson DR, Wright TL, Omary MB
Hepatology (Baltimore, Md.) 2004 Aug;40(2):459-66
Hepatology (Baltimore, Md.) 2004 Aug;40(2):459-66
Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury.
Ku NO, Soetikno RM, Omary MB
Hepatology (Baltimore, Md.) 2003 May;37(5):1006-14
Hepatology (Baltimore, Md.) 2003 May;37(5):1006-14
Keratin 8 mutations in patients with cryptogenic liver disease.
Ku NO, Gish R, Wright TL, Omary MB
The New England journal of medicine 2001 May 24;344(21):1580-7
The New England journal of medicine 2001 May 24;344(21):1580-7
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Flow cytometry analysis (intracellular staining) of HeLa cells with anti-cytokeratin 18 (DC-10) FITC Monoclonal antibody (Product # MA1-10327).
- Conjugate
- Green dye
