10-3013-F-25
antibody from ABEOMICS Inc.
Targeting: TLR5
FLJ10052, MGC126430, MGC126431, SLEB1, TIL3
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 10-3013-F-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-TLR5 Antibody
- Antibody type
- Monoclonal
- Description
- Toll-like receptor 5 (TLR5) plays a fundamental role in pathogen recognition and downstream signaling to induce effective immunity. It is well expressed in major old tissues including lung, skin, intestine, and spleen. TLR5 is present in synovial of patients with rheumatoid arthritis (RA), act as novel mediator of innate immunity-induced osteoclastogenesis and bone loss. TLR5 is a receptor for flagellin and is present on the basolateral surface of intestinal epithelial cells. It is involved in the migration of intestinal epithelial cells through activation of the p38 MAPK pathway. TLR5-mediated signaling specifically enhanced the maturation of lung dendritic cells. TLR5 influences the progression and outcome of ovarian, sarcoma, and luminal breast tumors. Mutations in TLR5 have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Green dye
- Antigen sequence
A partial length recombinant TLR5 p
rotein (amino acids 261-420) was us
ed as the immunogen for this antibo
dy.- Isotype
- IgG
- Antibody clone number
- ABM22G1
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Intracellular flow analysis of hTLR5 FITC conjugated in hTLR5 transfected cell line using 0.5 µg/10^6 cells of hTLR5 FITC conjugated antibody (Clone: ABM22G1). Green represents isotype control; red represents anti-hTLR5 FITC conjugated antibody.
- Protocol
- Protocol