Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [117]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 12544-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12544-1-AP, RRID:AB_2195888
- Product name
- SQLE antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SQLE antibody (Cat. #12544-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Icaritin Disrupts Cholesterol Biosynthesis and Induce Cell Death in Pancreatic Carcinoma: A Transcriptomic and Lipidomic Analysis.
Physiological role of plasmalogen homeostasis in the liver - A link to cholesterol metabolism.
NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin.
Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism.
Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression.
Sensing of Cholesterol by Squalene Monooxygenase.
Timosaponin A3 Ameliorates Prostate Cancer Progression via Upregulating STARD4 Mediated Cholesterol Metabolism.
Identification and validation of SQLE in steroid-induced osteonecrosis of the femoral head: a bioinformatics and experimental study.
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment.
Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment.
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors.
Malignant Hepatoblast-Like Cells Sustain Stemness via IGF2-Dependent Cholesterol Accumulation in Hepatoblastoma.
Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer.
Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy.
In-gel refolding allows fluorescence detection of fully denatured GFPs after SDS-PAGE.
DHODH Blockade Induces Ferroptosis in Neuroblastoma by Modulating the Mevalonate Pathway.
CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer.
SQLE amplification accelerates esophageal squamous cell carcinoma tumorigenesis and metastasis through oncometabolite 2,3-oxidosqualene repressing Hippo pathway.
Lactate supplementation after hypoglycemia alleviates cognitive dysfunction induced by recurrent non-severe hypoglycemia in diabetic mice.
Delactylation diminished the growth inhibitory role of CA3 by restoring DUOX2 expression in hepatocellular carcinoma.
Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE.
Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis.
Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer.
Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC.
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière's disease.
Effects of Cholesterol Metabolism on Corneal Endothelial Dysfunction in Patients With Type 1 Diabetes.
SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer.
Melatonin serves as a novel treatment in bladder fibrosis through TGF-β1/Smad and EMT.
SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer.
PKMYT1 knockdown inhibits cholesterol biosynthesis and promotes the drug sensitivity of triple-negative breast cancer cells to atorvastatin.
Cholesterol inhibition enhances antitumor response of gilteritinib in lung cancer cells.
Squalene monooxygenase (SQLE) protects ovarian cancer cells from ferroptosis.
SQLE-a promising prognostic biomarker in cervical cancer: implications for tumor malignant behavior, cholesterol synthesis, epithelial-mesenchymal transition, and immune infiltration.
Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis.
Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19.
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury.
The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues.
Discovery of anticancer function of Febrifugine: Inhibition of cell proliferation, induction of apoptosis and suppression steroid synthesis in bladder cancer cells.
Squalene monooxygenase facilitates bladder cancer development in part by regulating PCNA.
Cockayne Syndrome Patient iPSC-Derived Brain Organoids and Neurospheres Show Early Transcriptional Dysregulation of Biological Processes Associated with Brain Development and Metabolism.
Depletion of squalene epoxidase in synergy with glutathione peroxidase 4 inhibitor RSL3 overcomes oxidative stress resistance in lung squamous cell carcinoma.
Supplementation of Mangiferin to a High-Starch Diet Alleviates Hepatic Injury and Lipid Accumulation Potentially through Modulating Cholesterol Metabolism in Channel Catfish (Ictalurus punctatus).
Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE.
Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase.
Identifying squalene epoxidase as a metabolic vulnerability in high-risk osteosarcoma using an artificial intelligence-derived prognostic index.
Knockdown of SQLE promotes CD8+ T cell infiltration in the tumor microenvironment.
Topology surveillance of the lanosterol demethylase CYP51A1 by signal peptide peptidase.
Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity.
Large-Scale CRISPR Screen of LDLR Pathogenic Variants.
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells.
Molecular features and predictive models identify the most lethal subtype and a therapeutic target for osteosarcoma.
Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC.
Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.
Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6.
Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation.
Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.
Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase.
Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia.
Prognosis-related molecular subtyping in head and neck squamous cell carcinoma patients based on glycolytic/cholesterogenic gene data.
Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.
SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma.
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.
SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma.
Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer.
Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression.
AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.
Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.
ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.
Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.
Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression.
Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression.
SQLE inhibition suppresses the development of pancreatic ductal adenocarcinoma and enhances its sensitivity to chemotherapeutic agents in vitro.
Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.
Downregulated ferroptosis-related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastoma.
Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.
Comparative analysis of transient receptor potential channel 5 opposite strand-induced gene expression patterns and protein-protein interactions in triple-negative breast cancer.
Acetyl-CoA Deficiency Is Involved in the Regulation of Iron Overload on Lipid Metabolism in Apolipoprotein E Knockout Mice.
Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy.
A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer.
MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE.
High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma.
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth.
HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis.
The antiviral enzyme viperin inhibits cholesterol biosynthesis.
The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form.
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.
The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.
Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron.
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum.
Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene.
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB.
N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2.
The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.
Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence.
Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.
MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.
A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.
Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.
The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.
Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4.
Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses.
Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.
Diabetes and insulin in regulation of brain cholesterol metabolism.
Wei WC, Wang H, Shi D, Ai LS, Liu H
Chinese journal of integrative medicine 2026 May;32(5):442-450
Chinese journal of integrative medicine 2026 May;32(5):442-450
Physiological role of plasmalogen homeostasis in the liver - A link to cholesterol metabolism.
Honsho M, Dorninger F, Berger J, Singaraja RR, Trigueros-Motos L, Abe Y, Fujiki Y
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159695
Biochimica et biophysica acta. Molecular and cell biology of lipids 2026 Jan;1871(1):159695
NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin.
Wang Y, Yang X, Dong Y, Yang X, Hou Y, Fu Q, Yan J, Du Y, Zhang Q, Zhou Y, Wu A, Chang S, Xu J, Zhang C, Hu X, Meng H, Sun W, Liu D
iScience 2026 Jan 16;29(1):114488
iScience 2026 Jan 16;29(1):114488
Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism.
Vaquié AM, Shah DR, Brechbühl EES, McNicholas M, Xu Z, Stockley JH, Morcom L, Gold Diaz D, Girdler GC, Seear RV, Balmus G, Ratan RR, Bulstrode H, Nathan JA, Pathania M, Brindle KM, Rowitch DH
Molecular oncology 2026 Feb;20(2):307-330
Molecular oncology 2026 Feb;20(2):307-330
Cancer Cell-Intrinsic Cholesterol Induces Lipid-Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression.
Peng S, Lin W, Li Z, Zhuang R, Peng S, Li B, Chen B, Luo Y, Ou Y, Zhuang W, Du T, Li K, Huang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e08588
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e08588
Sensing of Cholesterol by Squalene Monooxygenase.
Coates HW, Brown AJ
Methods in molecular biology (Clifton, N.J.) 2025;2882:235-247
Methods in molecular biology (Clifton, N.J.) 2025;2882:235-247
Timosaponin A3 Ameliorates Prostate Cancer Progression via Upregulating STARD4 Mediated Cholesterol Metabolism.
Zhi Y, Ge L, Wang S, Zang W, Zhang Z, Xu T, Zhang Y, Song F, Huang P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 30;39(18):e71063
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 30;39(18):e71063
Identification and validation of SQLE in steroid-induced osteonecrosis of the femoral head: a bioinformatics and experimental study.
He Y, Qiao W, Zhang K, Shi X, Wang W
Journal of orthopaedic surgery and research 2025 Oct 17;20(1):894
Journal of orthopaedic surgery and research 2025 Oct 17;20(1):894
The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment.
Marzook NB, Song OR, Baumgärtel L, Bernitz N, Mkandawire TT, Watson LC, Nunes V, Warchal S, MacRae JI, Howell M, Sateriale A
Cell 2025 Oct 16;188(21):5947-5961.e15
Cell 2025 Oct 16;188(21):5947-5961.e15
Co-administration of berberine and evodiamine: Mitigating evodiamine-induced hepatotoxicity and potentiating colitis treatment.
Tao X, Gao Y, Jin Z, Lu S, Li Z, Guo S, Fan Q, Li J, Qiao C, Lei H, Zhang Z, Zhao C, Wu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157185
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157185
CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors.
Chen F, Li H, Wang Y, Tang X, Lin K, Li Q, Meng C, Shi W, Leo J, Liang X, Zhang J, Van V, Mahmud I, Wei B, Lorenzi PL, Raso MG, Aparicio A, Lu Y, Frigo DE, Gan B, Zhao D
Nature cancer 2025 May;6(5):854-873
Nature cancer 2025 May;6(5):854-873
Malignant Hepatoblast-Like Cells Sustain Stemness via IGF2-Dependent Cholesterol Accumulation in Hepatoblastoma.
Ding M, Mao S, Wu H, Fang S, Zhen N, Chen T, Zhu J, Tang X, Wang X, Sun F, Zhu G, Pan Q, Ma J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2407671
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2407671
Tylophora yunnanensis extract inhibits cholesterol biosynthesis to suppress triple negative breast cancer.
Feng ZH, Li WY, Li QZ, Zhao FB, Zhang HJ, Zhang L, Zhang H
Journal of ethnopharmacology 2025 May 28;348:119877
Journal of ethnopharmacology 2025 May 28;348:119877
Meisoindigo Acts as a Molecular Glue to Target PKMYT1 for Degradation in Chronic Myeloid Leukemia Therapy.
Zhang ZX, Li SY, Li FF, Shi QY, Tan CY, Wang XJ, Li M, Liu YB, Jin J, Li Y, Yu SS
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2413676
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2413676
In-gel refolding allows fluorescence detection of fully denatured GFPs after SDS-PAGE.
Shiratori M, Tsuyuki R, Asanuma M, Kawabata S, Yoshioka H, Ohgane K
Analytical biochemistry 2025 Jul;702:115861
Analytical biochemistry 2025 Jul;702:115861
DHODH Blockade Induces Ferroptosis in Neuroblastoma by Modulating the Mevalonate Pathway.
Shir JC, Chen PY, Kuo CH, Hsieh CH, Chang HY, Lee HC, Huang CH, Hsu CH, Hsu WM, Huang HC, Juan HF
Molecular & cellular proteomics : MCP 2025 Jul;24(7):101014
Molecular & cellular proteomics : MCP 2025 Jul;24(7):101014
CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer.
Cai H, Xue P, Liu S, Ma Y, Zeng X, Yan S, Xu N
Journal of nanobiotechnology 2025 Jul 22;23(1):534
Journal of nanobiotechnology 2025 Jul 22;23(1):534
SQLE amplification accelerates esophageal squamous cell carcinoma tumorigenesis and metastasis through oncometabolite 2,3-oxidosqualene repressing Hippo pathway.
Liu X, Lv M, Feng B, Gong Y, Min Q, Wang Y, Wu Q, Chen J, Zhao D, Li J, Zhang W, Zhan Q
Cancer letters 2025 Jul 1;621:217528
Cancer letters 2025 Jul 1;621:217528
Lactate supplementation after hypoglycemia alleviates cognitive dysfunction induced by recurrent non-severe hypoglycemia in diabetic mice.
Wu Y, Gao R, Huang Q, Huang C, Wang L, Lin L, He G, Wu K, Liu X, Liu X, Liu L
Experimental neurology 2025 Jan;383:115037
Experimental neurology 2025 Jan;383:115037
Delactylation diminished the growth inhibitory role of CA3 by restoring DUOX2 expression in hepatocellular carcinoma.
Yan J, Zhou Y, Xu J, Dong Y, Yang X, Yang X, Wu A, Chang S, Wang Y, Zhang Q, Ayaka T, Yu L, Zhao L, Meng H, Liu D
Experimental cell research 2025 Jan 15;444(2):114392
Experimental cell research 2025 Jan 15;444(2):114392
Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE.
Liu S, Zhang N, Ji X, Yang S, Zhao Z, Li P
Cell death & disease 2025 Jan 14;16(1):17
Cell death & disease 2025 Jan 14;16(1):17
Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis.
Chang S, Tomii A, Zhou Y, Yang X, Dong Y, Yan J, Wu A, Wang Y, Zhang Q, Meng H, Yu L, Sun W, Liu D
iScience 2025 Feb 21;28(2):111731
iScience 2025 Feb 21;28(2):111731
Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer.
Chen J, Cui H, Wang X, Zeng Y, Pan D, Chen J, Zhang Z, An Y, Gu Z, Cai G, Wang H, Yu M, Yang B, Zhou S, Tan J, Liu L, Wang J, Li J, Han F
Journal of translational medicine 2025 Dec 9;23(1):1390
Journal of translational medicine 2025 Dec 9;23(1):1390
Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC.
Yang X, Wu Y, Zhang Q, Zhou Y, Chang S, Zhang C, Liu D
BMC cancer 2025 Dec 13;26(1):81
BMC cancer 2025 Dec 13;26(1):81
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière's disease.
Harhai M, Foged MM, Zarges C, Landoni JC, Chollet S, Simonelli M, Recazens E, Lisci M, Laban N, Manley S, Riemer J, Lopez-Escamez JA, Lysakowski A, Jourdain AA
Cell reports 2025 Aug 26;44(8):116069
Cell reports 2025 Aug 26;44(8):116069
Effects of Cholesterol Metabolism on Corneal Endothelial Dysfunction in Patients With Type 1 Diabetes.
Ren Z, Li Z, Dou S, Zhao H, Xie L
Investigative ophthalmology & visual science 2025 Aug 1;66(11):9
Investigative ophthalmology & visual science 2025 Aug 1;66(11):9
SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer.
Pan J, Liu R, Lu W, Peng H, Yang J, Zhang Q, Yu T, Huo B, Wei X, Liang H, Zhou L, Sun Y, Hu Y, Wen S, Fu J, Chiao PJ, Xia X, Liu J, Huang P
Cancer letters 2025 Apr 28;616:217586
Cancer letters 2025 Apr 28;616:217586
Melatonin serves as a novel treatment in bladder fibrosis through TGF-β1/Smad and EMT.
Zhang Y, Gong S, He W, Yuan J, Dong D, Zhang J, Wang H, Chen B
PloS one 2024;19(3):e0295104
PloS one 2024;19(3):e0295104
SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer.
Pan J, Liang H, Zhou L, Lu W, Huo B, Liu R, Huang P
Frontiers in immunology 2024;15:1512981
Frontiers in immunology 2024;15:1512981
PKMYT1 knockdown inhibits cholesterol biosynthesis and promotes the drug sensitivity of triple-negative breast cancer cells to atorvastatin.
Gao W, Guo X, Sun L, Gai J, Cao Y, Zhang S
PeerJ 2024;12:e17749
PeerJ 2024;12:e17749
Cholesterol inhibition enhances antitumor response of gilteritinib in lung cancer cells.
Sun CY, Cao D, Wang YN, Weng NQ, Ren QN, Wang SC, Zhang MY, Mai SJ, Wang HY
Cell death & disease 2024 Sep 30;15(9):704
Cell death & disease 2024 Sep 30;15(9):704
Squalene monooxygenase (SQLE) protects ovarian cancer cells from ferroptosis.
Zhang R, Zhang L, Fan S, Wang L, Wang B, Wang L
Scientific reports 2024 Sep 30;14(1):22646
Scientific reports 2024 Sep 30;14(1):22646
SQLE-a promising prognostic biomarker in cervical cancer: implications for tumor malignant behavior, cholesterol synthesis, epithelial-mesenchymal transition, and immune infiltration.
Zhao YC, Li YF, Qiu L, Jin SZ, Shen YN, Zhang CH, Cui J, Wang TJ
BMC cancer 2024 Sep 11;24(1):1133
BMC cancer 2024 Sep 11;24(1):1133
Development of a monoclonal antibody to study MARCH6, an E3 ligase that regulates proteins that control lipid homeostasis.
Xu S, Donnelly L, Kober DL, Mak M, Radhakrishnan A
Journal of lipid research 2024 Nov;65(11):100650
Journal of lipid research 2024 Nov;65(11):100650
Increased adrenal steroidogenesis and suppressed corticosteroid responsiveness in critical COVID-19.
Wen TZ, Li TR, Chen XY, Chen HY, Wang S, Fu WJ, Xiao SQ, Luo J, Tang R, Ji JL, Huang JF, He ZC, Luo T, Zhao HL, Chen C, Miao JY, Niu Q, Wang Y, Bian XW, Yao XH
Metabolism: clinical and experimental 2024 Nov;160:155980
Metabolism: clinical and experimental 2024 Nov;160:155980
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury.
Lin H, Ma C, Zhuang X, Liu S, Liu D, Zhang M, Lu Y, Zhou G, Zhang C, Wang T, Zhang Z, Lv L, Zhang D, Ruan XZ, Xu Y, Chai R, Yu X, Sun JP, Chu B
Cell metabolism 2024 Nov 5;36(11):2402-2418.e10
Cell metabolism 2024 Nov 5;36(11):2402-2418.e10
The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues.
Coates HW, Nguyen TB, Du X, Olzomer EM, Farrell R, Byrne FL, Yang H, Brown AJ
The Journal of biological chemistry 2024 May;300(5):107232
The Journal of biological chemistry 2024 May;300(5):107232
Discovery of anticancer function of Febrifugine: Inhibition of cell proliferation, induction of apoptosis and suppression steroid synthesis in bladder cancer cells.
Chen J, Fan S, Guo J, Yang J, Pan L, Xia Y
Toxicology and applied pharmacology 2024 Mar;484:116878
Toxicology and applied pharmacology 2024 Mar;484:116878
Squalene monooxygenase facilitates bladder cancer development in part by regulating PCNA.
Zhu C, Fang X, Liu X, Jiang C, Ren W, Huang W, Jiang Y, Wang D
Biochimica et biophysica acta. Molecular cell research 2024 Mar;1871(3):119681
Biochimica et biophysica acta. Molecular cell research 2024 Mar;1871(3):119681
Cockayne Syndrome Patient iPSC-Derived Brain Organoids and Neurospheres Show Early Transcriptional Dysregulation of Biological Processes Associated with Brain Development and Metabolism.
Szepanowski LP, Wruck W, Kapr J, Rossi A, Fritsche E, Krutmann J, Adjaye J
Cells 2024 Mar 28;13(7)
Cells 2024 Mar 28;13(7)
Depletion of squalene epoxidase in synergy with glutathione peroxidase 4 inhibitor RSL3 overcomes oxidative stress resistance in lung squamous cell carcinoma.
Li G, Chen L, Bai H, Zhang L, Wang J, Li W
Precision clinical medicine 2024 Jun;7(2):pbae011
Precision clinical medicine 2024 Jun;7(2):pbae011
Supplementation of Mangiferin to a High-Starch Diet Alleviates Hepatic Injury and Lipid Accumulation Potentially through Modulating Cholesterol Metabolism in Channel Catfish (Ictalurus punctatus).
Zheng Y, Lu Q, Cao J, Liu Y, Liu H, Jin J, Zhang Z, Yang Y, Zhu X, Han D, Xie S
Antioxidants (Basel, Switzerland) 2024 Jun 13;13(6)
Antioxidants (Basel, Switzerland) 2024 Jun 13;13(6)
Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE.
Botsch JJ, Junker R, Sorgenfrei M, Ogger PP, Stier L, von Gronau S, Murray PJ, Seeger MA, Schulman BA, Bräuning B
Nature communications 2024 Jan 9;15(1):410
Nature communications 2024 Jan 9;15(1):410
Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase.
Avci D, Heidasch R, Costa M, Lüchtenborg C, Kale D, Brügger B, Lemberg MK
The Journal of biological chemistry 2024 Feb;300(2):105644
The Journal of biological chemistry 2024 Feb;300(2):105644
Identifying squalene epoxidase as a metabolic vulnerability in high-risk osteosarcoma using an artificial intelligence-derived prognostic index.
Wang Y, Ma X, Xu E, Huang Z, Yang C, Zhu K, Dong Y, Zhang C
Clinical and translational medicine 2024 Feb;14(2):e1586
Clinical and translational medicine 2024 Feb;14(2):e1586
Knockdown of SQLE promotes CD8+ T cell infiltration in the tumor microenvironment.
Wu J, Hu W, Yang W, Long Y, Chen K, Li F, Ma X, Li X
Cellular signalling 2024 Feb;114:110983
Cellular signalling 2024 Feb;114:110983
Topology surveillance of the lanosterol demethylase CYP51A1 by signal peptide peptidase.
Sergejevs N, Avci D, van de Weijer ML, Corey RA, Lemberg MK, Carvalho P
Journal of cell science 2024 Dec 1;137(23)
Journal of cell science 2024 Dec 1;137(23)
Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity.
Liu Y, Wang Z, Jin H, Cui L, Huo B, Xie C, Li J, Ding H, Zhang H, Xiong W, Li M, Zhang H, Guo H, Li C, Wang T, Wang X, He W, Wang Z, Bei JX, Huang P, Liu J, Xia X
Cell reports 2024 Apr 23;43(4):114094
Cell reports 2024 Apr 23;43(4):114094
Large-Scale CRISPR Screen of LDLR Pathogenic Variants.
Li M, Ma L, Chen Y, Li J, Wang Y, You W, Yuan H, Tang X, Ouyang H, Pang D
Research (Washington, D.C.) 2023;6:0203
Research (Washington, D.C.) 2023;6:0203
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells.
Zhou H, Xu L, Shi Y, Gu S, Wu N, Liu F, Huang Y, Qian Z, Xue W, Wang X, Chen F
Biological & pharmaceutical bulletin 2023;46(1):42-51
Biological & pharmaceutical bulletin 2023;46(1):42-51
Molecular features and predictive models identify the most lethal subtype and a therapeutic target for osteosarcoma.
Zheng K, Hou Y, Zhang Y, Wang F, Sun A, Yang D
Frontiers in oncology 2023;13:1111570
Frontiers in oncology 2023;13:1111570
Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC.
Zhao X, Guo B, Sun W, Yu J, Cui L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2206878
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2206878
Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.
Miao X, Ye H, Cui X, Guo X, Su F
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
Zhang X, Dong Z, Yang Y, Liu C, Li J, Sun W, Zhu Y, Shen Y, Wang Z, Lü M, Cui H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.
Sun Q, Liu D, Cui W, Cheng H, Huang L, Zhang R, Gu J, Liu S, Zhuang X, Lu Y, Chu B, Li J
Communications biology 2023 Nov 1;6(1):1108
Communications biology 2023 Nov 1;6(1):1108
Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6.
Qian L, Scott NA, Capell-Hattam IM, Draper EA, Fenton NM, Luu W, Sharpe LJ, Brown AJ
Journal of lipid research 2023 May;64(5):100362
Journal of lipid research 2023 May;64(5):100362
Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation.
Kong Y, Wu M, Wan X, Sun M, Zhang Y, Wu Z, Li C, Liang X, Gao L, Ma C, Yue X
Redox biology 2023 Jul;63:102732
Redox biology 2023 Jul;63:102732
Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
Mun SH, Lee CS, Kim HJ, Kim J, Lee H, Yang J, Im SH, Kim JH, Seong JK, Hwang CS
Cell reports 2023 Jul 25;42(7):112746
Cell reports 2023 Jul 25;42(7):112746
A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.
Zhou M, Kong B, Zhang X, Xiao K, Lu J, Li W, Li M, Li Z, Ji W, Hou J, Xu T
iScience 2023 Jul 21;26(7):107159
iScience 2023 Jul 21;26(7):107159
Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.
Yan C, Zheng L, Jiang S, Yang H, Guo J, Jiang LY, Li T, Zhang H, Bai Y, Lou Y, Zhang Q, Liang T, Schamel W, Wang H, Yang W, Wang G, Zhu ZJ, Song BL, Xu C
Cancer cell 2023 Jul 10;41(7):1276-1293.e11
Cancer cell 2023 Jul 10;41(7):1276-1293.e11
Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase.
Coates HW, Capell-Hattam IM, Olzomer EM, Du X, Farrell R, Yang H, Byrne FL, Brown AJ
eLife 2023 Jan 19;12
eLife 2023 Jan 19;12
Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia.
Zou X, Liao Y, Liu Z, Xu X, Sun W, Qin H, Wang H, Liu J, Jing T
Journal of cardiovascular translational research 2023 Feb;16(1):112-126
Journal of cardiovascular translational research 2023 Feb;16(1):112-126
Prognosis-related molecular subtyping in head and neck squamous cell carcinoma patients based on glycolytic/cholesterogenic gene data.
Zhou Z, Tang J, Lu Y, Jia J, Luo T, Su K, Dai X, Zhang H, Liu O
Cancer cell international 2023 Feb 25;23(1):37
Cancer cell international 2023 Feb 25;23(1):37
Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.
Tuluhong D, Gao H, Li X, Wang L, Zhu Y, Xu C, Wang J, Li H, Li Q, Wang S
Experimental cell research 2023 Dec 1;433(1):113805
Experimental cell research 2023 Dec 1;433(1):113805
SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.
Xu R, Song J, Ruze R, Chen Y, Yin X, Wang C, Zhao Y
Cell death & disease 2023 Aug 4;14(8):497
Cell death & disease 2023 Aug 4;14(8):497
Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma.
Ye Z, Ai X, Yang K, Yang Z, Fei F, Liao X, Qiu Z, Gimple RC, Yuan H, Huang H, Gong Y, Xiao C, Yue J, Huang L, Saulnier O, Wang W, Zhang P, Dai L, Wang X, Wang X, Ahn YH, You C, Xu J, Wan X, Taylor MD, Zhao L, Rich JN, Zhou S
Cancer discovery 2023 Apr 3;13(4):974-1001
Cancer discovery 2023 Apr 3;13(4):974-1001
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
Li J, Yang T, Wang Q, Li Y, Wu H, Zhang M, Qi H, Zhang H, Li J
International journal of biological sciences 2022;18(9):3576-3591
International journal of biological sciences 2022;18(9):3576-3591
Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.
Li MT, Liu LL, Zhou Q, Huang LX, Shi YX, Hou JB, Lu HT, Yu B, Chen W, Guo ZY
Frontiers in pharmacology 2022;13:891788
Frontiers in pharmacology 2022;13:891788
SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma.
You W, Ke J, Chen Y, Cai Z, Huang ZP, Hu P, Wu X
Frontiers in immunology 2022;13:864244
Frontiers in immunology 2022;13:864244
Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer.
Shangguan X, Ma Z, Yu M, Ding J, Xue W, Qi J
Cancer research 2022 Sep 2;82(17):3032-3044
Cancer research 2022 Sep 2;82(17):3032-3044
Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression.
Hu LP, Huang W, Wang X, Xu C, Qin WT, Li D, Tian G, Li Q, Zhou Y, Chen S, Nie HZ, Hao Y, Song J, Zhang XL, Sundquist J, Sundquist K, Li J, Jiang SH, Zhang ZG, Ji J
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Oct 5;30(10):3284-3299
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Oct 5;30(10):3284-3299
AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.
Sheng N, Wang YQ, Wang CF, Jia MQ, Niu HM, Lu QQ, Wang YN, Feng D, Zheng XX, Yuan HQ
Acta pharmacologica Sinica 2022 Nov;43(11):2905-2916
Acta pharmacologica Sinica 2022 Nov;43(11):2905-2916
Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.
Wang Y, Wang Y, Ding L, Ren X, Wang B, Wang L, Zhao S, Yue X, Wu Z, Li C, Liang X, Ma C, Gao L
Cell reports 2022 Nov 29;41(9):111738
Cell reports 2022 Nov 29;41(9):111738
ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.
McKenna MJ, Adams BM, Chu V, Paulo JA, Shao S
Molecular cell 2022 Nov 17;82(22):4277-4289.e10
Molecular cell 2022 Nov 17;82(22):4277-4289.e10
Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.
Guo C, Wan R, He Y, Lin SH, Cao J, Qiu Y, Zhang T, Zhao Q, Niu Y, Jin Y, Huang HY, Wang X, Tan L, Thomas RK, Zhang H, Chen L, Wong KK, Hu L, Ji H
Nature cancer 2022 May;3(5):614-628
Nature cancer 2022 May;3(5):614-628
Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression.
Gouirand V, Gicquel T, Lien EC, Jaune-Pons E, Da Costa Q, Finetti P, Metay E, Duluc C, Mayers JR, Audebert S, Camoin L, Borge L, Rubis M, Leca J, Nigri J, Bertucci F, Dusetti N, Iovanna JL, Tomasini R, Bidaut G, Guillaumond F, Vander Heiden MG, Vasseur S
The EMBO journal 2022 May 2;41(9):e110466
The EMBO journal 2022 May 2;41(9):e110466
Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression.
Jiang H, Tang E, Chen Y, Liu H, Zhao Y, Lin M, He L
Cancer science 2022 Mar;113(3):971-985
Cancer science 2022 Mar;113(3):971-985
SQLE inhibition suppresses the development of pancreatic ductal adenocarcinoma and enhances its sensitivity to chemotherapeutic agents in vitro.
Zhao F, Huang Y, Zhang Y, Li X, Chen K, Long Y, Li F, Ma X
Molecular biology reports 2022 Jul;49(7):6613-6621
Molecular biology reports 2022 Jul;49(7):6613-6621
Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.
Xu XY, Choi HS, Park SY, Kim JK, Seo KH, Kim H, Kim YJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153870
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153870
Downregulated ferroptosis-related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastoma.
Yao L, Li J, Zhang X, Zhou L, Hu K
CNS neuroscience & therapeutics 2022 Dec;28(12):2104-2115
CNS neuroscience & therapeutics 2022 Dec;28(12):2104-2115
Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.
Ho GY, Kyran EL, Bedo J, Wakefield MJ, Ennis DP, Mirza HB, Vandenberg CJ, Lieschke E, Farrell A, Hadla A, Lim R, Dall G, Vince JE, Chua NK, Kondrashova O, Upstill-Goddard R, Bailey UM, Dowson S, Roxburgh P, Glasspool RM, Bryson G, Biankin AV, Scottish Genomes Partnership, Cooke SL, Ratnayake G, McNally O, Traficante N, Australian Ovarian Cancer Study12,13, DeFazio A, Weroha SJ, Bowtell DD, McNeish IA, Papenfuss AT, Scott CL, Barker HE
Cancer research 2022 Dec 2;82(23):4457-4473
Cancer research 2022 Dec 2;82(23):4457-4473
Comparative analysis of transient receptor potential channel 5 opposite strand-induced gene expression patterns and protein-protein interactions in triple-negative breast cancer.
Peng J, Pei S, Cui Y, Xia Y, Huang Y, Wu X, Zheng M, Weng M, Han X, Fu H, Yang L, Zhou W, Fu Z, Wang S, Xie H
Oncology letters 2022 Aug;24(2):259
Oncology letters 2022 Aug;24(2):259
Acetyl-CoA Deficiency Is Involved in the Regulation of Iron Overload on Lipid Metabolism in Apolipoprotein E Knockout Mice.
Luo G, Xiang L, Xiao L
Molecules (Basel, Switzerland) 2022 Aug 4;27(15)
Molecules (Basel, Switzerland) 2022 Aug 4;27(15)
Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy.
Hong Z, Liu T, Wan L, Fa P, Kumar P, Cao Y, Prasad CB, Qiu Z, Liu J, Wang H, Li Z, Wang QE, Guo P, Guo D, Yilmaz AS, Lu L, Papandreou I, Jacob NK, Yan C, Zhang X, She QB, Ma Z, Zhang J
Cancer research 2022 Apr 1;82(7):1298-1312
Cancer research 2022 Apr 1;82(7):1298-1312
A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer.
Yan Y, Cai J, Huang Z, Cao X, Tang P, Wang Z, Zhang F, Xia S, Shen B
Frontiers in cell and developmental biology 2021;9:712230
Frontiers in cell and developmental biology 2021;9:712230
MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE.
Yang F, Kou J, Liu Z, Li W, Du W
Frontiers in cell and developmental biology 2021;9:655889
Frontiers in cell and developmental biology 2021;9:655889
High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma.
Liu Y, Fang L, Liu W
Cancer management and research 2021;13:4709-4723
Cancer management and research 2021;13:4709-4723
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth.
Sun H, Li L, Li W, Yang F, Zhang Z, Liu Z, Du W
EMBO reports 2021 Oct 5;22(10):e52537
EMBO reports 2021 Oct 5;22(10):e52537
HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis.
Zhang Z, Wen H, Peng B, Weng J, Zeng F
Molecular therapy. Nucleic acids 2021 Jun 4;24:711-727
Molecular therapy. Nucleic acids 2021 Jun 4;24:711-727
The antiviral enzyme viperin inhibits cholesterol biosynthesis.
Grunkemeyer TJ, Ghosh S, Patel AM, Sajja K, Windak J, Basrur V, Kim Y, Nesvizhskii AI, Kennedy RT, Marsh ENG
The Journal of biological chemistry 2021 Jul;297(1):100824
The Journal of biological chemistry 2021 Jul;297(1):100824
The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form.
Coates HW, Capell-Hattam IM, Brown AJ
The Journal of biological chemistry 2021 Jan-Jun;296:100731
The Journal of biological chemistry 2021 Jan-Jun;296:100731
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.
He L, Li H, Pan C, Hua Y, Peng J, Zhou Z, Zhao Y, Lin M
Cancer communications (London, England) 2021 Aug;41(8):726-746
Cancer communications (London, England) 2021 Aug;41(8):726-746
MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Müller A, Spahn M, Seitz AK, Frank T, Marouf H, Büchel G, Eckstein M, Kübler H, Eilers M, Saar M, Junker K, Röhrig F, Kneitz B, Rosenfeldt MT, Schulze A
Nature communications 2021 Aug 20;12(1):5066
Nature communications 2021 Aug 20;12(1):5066
The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.
Scott NA, Sharpe LJ, Capell-Hattam IM, Gullo SJ, Luu W, Brown AJ
The Biochemical journal 2020 Jan 31;477(2):541-555
The Biochemical journal 2020 Jan 31;477(2):541-555
Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8
The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.
Tan JME, van der Stoel MM, van den Berg M, van Loon NM, Moeton M, Scholl E, van der Wel NN, Kovačević I, Hordijk PL, Loregger A, Huveneers S, Zelcer N
Cell reports 2020 Aug 4;32(5):107944
Cell reports 2020 Aug 4;32(5):107944
Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron.
Chua NK, Scott NA, Brown AJ
The Biochemical journal 2019 Sep 20;476(18):2545-2560
The Biochemical journal 2019 Sep 20;476(18):2545-2560
OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.
Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X
Experimental cell research 2019 Oct 15;383(2):111512
Experimental cell research 2019 Oct 15;383(2):111512
Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum.
Honsho M, Dorninger F, Abe Y, Setoyama D, Ohgi R, Uchiumi T, Kang D, Berger J, Fujiki Y
Journal of biochemistry 2019 Oct 1;166(4):353-361
Journal of biochemistry 2019 Oct 1;166(4):353-361
Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene.
Coates HW, Chua NK, Brown AJ
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 Nov;1864(11):1656-1668
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 Nov;1864(11):1656-1668
Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.
Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, Birsoy K
Nature 2019 Mar;567(7746):118-122
Nature 2019 Mar;567(7746):118-122
FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB.
Pronk MCA, Majolée J, Loregger A, van Bezu JSM, Zelcer N, Hordijk PL, Kovačević I
Molecular biology of the cell 2019 Mar 1;30(5):607-621
Molecular biology of the cell 2019 Mar 1;30(5):607-621
N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2.
Nguyen KT, Lee CS, Mun SH, Truong NT, Park SK, Hwang CS
The Journal of biological chemistry 2019 Jan 4;294(1):379-388
The Journal of biological chemistry 2019 Jan 4;294(1):379-388
The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.
Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC
Journal of cell science 2019 Jan 16;132(2)
Journal of cell science 2019 Jan 16;132(2)
Inhibition of the 60S ribosome biogenesis GTPase LSG1 causes endoplasmic reticular disruption and cellular senescence.
Pantazi A, Quintanilla A, Hari P, Tarrats N, Parasyraki E, Dix FL, Patel J, Chandra T, Acosta JC, Finch AJ
Aging cell 2019 Aug;18(4):e12981
Aging cell 2019 Aug;18(4):e12981
Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.
Werner E, Alter A, Deng Q, Dammer EB, Wang Y, Yu DS, Duong DM, Seyfried NT, Doetsch PW
Scientific reports 2019 Aug 29;9(1):12546
Scientific reports 2019 Aug 29;9(1):12546
MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
Loregger A, Raaben M, Tan J, Scheij S, Moeton M, van den Berg M, Gelberg-Etel H, Stickel E, Roitelman J, Brummelkamp T, Zelcer N
Arteriosclerosis, thrombosis, and vascular biology 2017 Nov;37(11):2064-2074
Arteriosclerosis, thrombosis, and vascular biology 2017 Nov;37(11):2064-2074
Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.
Haider S, McIntyre A, van Stiphout RG, Winchester LM, Wigfield S, Harris AL, Buffa FM
Genome biology 2016 Jun 29;17(1):140
Genome biology 2016 Jun 29;17(1):140
A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.
Loregger A, Cook EC, Nelson JK, Moeton M, Sharpe LJ, Engberg S, Karimova M, Lambert G, Brown AJ, Zelcer N
Molecular and cellular biology 2016 Jan 15;36(2):285-94
Molecular and cellular biology 2016 Jan 15;36(2):285-94
Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.
Honsho M, Abe Y, Fujiki Y
The Journal of biological chemistry 2015 Nov 27;290(48):28822-33
The Journal of biological chemistry 2015 Nov 27;290(48):28822-33
The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.
Zelcer N, Sharpe LJ, Loregger A, Kristiana I, Cook EC, Phan L, Stevenson J, Brown AJ
Molecular and cellular biology 2014 Apr;34(7):1262-70
Molecular and cellular biology 2014 Apr;34(7):1262-70
Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.
Suzuki R, Ferris HA, Chee MJ, Maratos-Flier E, Kahn CR
PLoS biology 2013;11(4):e1001532
PLoS biology 2013;11(4):e1001532
Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4.
Foresti O, Ruggiano A, Hannibal-Bach HK, Ejsing CS, Carvalho P
eLife 2013 Jul 23;2:e00953
eLife 2013 Jul 23;2:e00953
Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses.
Kristiana I, Luu W, Stevenson J, Cartland S, Jessup W, Belani JD, Rychnovsky SD, Brown AJ
The Journal of biological chemistry 2012 Sep 28;287(40):33897-904
The Journal of biological chemistry 2012 Sep 28;287(40):33897-904
Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.
Gill S, Stevenson J, Kristiana I, Brown AJ
Cell metabolism 2011 Mar 2;13(3):260-73
Cell metabolism 2011 Mar 2;13(3):260-73
Diabetes and insulin in regulation of brain cholesterol metabolism.
Suzuki R, Lee K, Jing E, Biddinger SB, McDonald JG, Montine TJ, Craft S, Kahn CR
Cell metabolism 2010 Dec 1;12(6):567-79
Cell metabolism 2010 Dec 1;12(6):567-79
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A549 cells were subjected to SDS PAGE followed by western blot with 12544-1-AP(SQLE antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SQLE antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SQLE. This antibody recognizes human,mouse,rat antigen. The SQLE antibody has been validated for the following applications: ELISA, WB, IHC analysis.
