12544-1-AP

antibody from Proteintech Group

Targeting: SQLE

Provider product page for 12544-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [79]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 12544-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12544-1-AP, RRID:AB_2195888
Product name: SQLE antibody
Antibody type: Polyclonal
Description: KD/KO validated SQLE antibody (Cat. #12544-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SQLE protein structure - 12544-1-AP shown in red.

Submitted references Melatonin serves as a novel treatment in bladder fibrosis through TGF-β1/Smad and EMT.

Zhang Y, Gong S, He W, Yuan J, Dong D, Zhang J, Wang H, Chen B
PloS one 2024;19(3):e0295104

The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues.

Coates HW, Nguyen TB, Du X, Olzomer EM, Farrell R, Byrne FL, Yang H, Brown AJ
The Journal of biological chemistry 2024 May;300(5):107232

Discovery of anticancer function of Febrifugine: Inhibition of cell proliferation, induction of apoptosis and suppression steroid synthesis in bladder cancer cells.

Chen J, Fan S, Guo J, Yang J, Pan L, Xia Y
Toxicology and applied pharmacology 2024 Mar;484:116878

Squalene monooxygenase facilitates bladder cancer development in part by regulating PCNA.

Zhu C, Fang X, Liu X, Jiang C, Ren W, Huang W, Jiang Y, Wang D
Biochimica et biophysica acta. Molecular cell research 2024 Mar;1871(3):119681

Cockayne Syndrome Patient iPSC-Derived Brain Organoids and Neurospheres Show Early Transcriptional Dysregulation of Biological Processes Associated with Brain Development and Metabolism.

Szepanowski LP, Wruck W, Kapr J, Rossi A, Fritsche E, Krutmann J, Adjaye J
Cells 2024 Mar 28;13(7)

Depletion of squalene epoxidase in synergy with glutathione peroxidase 4 inhibitor RSL3 overcomes oxidative stress resistance in lung squamous cell carcinoma.

Li G, Chen L, Bai H, Zhang L, Wang J, Li W
Precision clinical medicine 2024 Jun;7(2):pbae011

Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE.

Botsch JJ, Junker R, Sorgenfrei M, Ogger PP, Stier L, von Gronau S, Murray PJ, Seeger MA, Schulman BA, Bräuning B
Nature communications 2024 Jan 9;15(1):410

Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase.

Avci D, Heidasch R, Costa M, Lüchtenborg C, Kale D, Brügger B, Lemberg MK
The Journal of biological chemistry 2024 Feb;300(2):105644

Identifying squalene epoxidase as a metabolic vulnerability in high-risk osteosarcoma using an artificial intelligence-derived prognostic index.

Wang Y, Ma X, Xu E, Huang Z, Yang C, Zhu K, Dong Y, Zhang C
Clinical and translational medicine 2024 Feb;14(2):e1586

Knockdown of SQLE promotes CD8+ T cell infiltration in the tumor microenvironment.

Wu J, Hu W, Yang W, Long Y, Chen K, Li F, Ma X, Li X
Cellular signalling 2024 Feb;114:110983

Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity.

Liu Y, Wang Z, Jin H, Cui L, Huo B, Xie C, Li J, Ding H, Zhang H, Xiong W, Li M, Zhang H, Guo H, Li C, Wang T, Wang X, He W, Wang Z, Bei JX, Huang P, Liu J, Xia X
Cell reports 2024 Apr 23;43(4):114094

Large-Scale CRISPR Screen of LDLR Pathogenic Variants.

Li M, Ma L, Chen Y, Li J, Wang Y, You W, Yuan H, Tang X, Ouyang H, Pang D
Research (Washington, D.C.) 2023;6:0203

A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells.

Zhou H, Xu L, Shi Y, Gu S, Wu N, Liu F, Huang Y, Qian Z, Xue W, Wang X, Chen F
Biological & pharmaceutical bulletin 2023;46(1):42-51

Molecular features and predictive models identify the most lethal subtype and a therapeutic target for osteosarcoma.

Zheng K, Hou Y, Zhang Y, Wang F, Sun A, Yang D
Frontiers in oncology 2023;13:1111570

Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC.

Zhao X, Guo B, Sun W, Yu J, Cui L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(27):e2206878

Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.

Miao X, Ye H, Cui X, Guo X, Su F
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131

Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.

Zhang X, Dong Z, Yang Y, Liu C, Li J, Sun W, Zhu Y, Shen Y, Wang Z, Lü M, Cui H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031

Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.

Sun Q, Liu D, Cui W, Cheng H, Huang L, Zhang R, Gu J, Liu S, Zhuang X, Lu Y, Chu B, Li J
Communications biology 2023 Nov 1;6(1):1108

Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6.

Qian L, Scott NA, Capell-Hattam IM, Draper EA, Fenton NM, Luu W, Sharpe LJ, Brown AJ
Journal of lipid research 2023 May;64(5):100362

Lipophagy-mediated cholesterol synthesis inhibition is required for the survival of hepatocellular carcinoma under glutamine deprivation.

Kong Y, Wu M, Wan X, Sun M, Zhang Y, Wu Z, Li C, Liang X, Gao L, Ma C, Yue X
Redox biology 2023 Jul;63:102732

Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.

Mun SH, Lee CS, Kim HJ, Kim J, Lee H, Yang J, Im SH, Kim JH, Seong JK, Hwang CS
Cell reports 2023 Jul 25;42(7):112746

A proximity labeling strategy enables proteomic analysis of inter-organelle membrane contacts.

Zhou M, Kong B, Zhang X, Xiao K, Lu J, Li W, Li M, Li Z, Ji W, Hou J, Xu T
iScience 2023 Jul 21;26(7):107159

Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.

Yan C, Zheng L, Jiang S, Yang H, Guo J, Jiang LY, Li T, Zhang H, Bai Y, Lou Y, Zhang Q, Liang T, Schamel W, Wang H, Yang W, Wang G, Zhu ZJ, Song BL, Xu C
Cancer cell 2023 Jul 10;41(7):1276-1293.e11

Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase.

Coates HW, Capell-Hattam IM, Olzomer EM, Du X, Farrell R, Yang H, Byrne FL, Brown AJ
eLife 2023 Jan 19;12

Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia.

Zou X, Liao Y, Liu Z, Xu X, Sun W, Qin H, Wang H, Liu J, Jing T
Journal of cardiovascular translational research 2023 Feb;16(1):112-126

Zhou Z, Tang J, Lu Y, Jia J, Luo T, Su K, Dai X, Zhang H, Liu O
Cancer cell international 2023 Feb 25;23(1):37

Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.

Tuluhong D, Gao H, Li X, Wang L, Zhu Y, Xu C, Wang J, Li H, Li Q, Wang S
Experimental cell research 2023 Dec 1;433(1):113805

SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway.

Xu R, Song J, Ruze R, Chen Y, Yin X, Wang C, Zhao Y
Cell death & disease 2023 Aug 4;14(8):497

Targeting Microglial Metabolic Rewiring Synergizes with Immune-Checkpoint Blockade Therapy for Glioblastoma.

Ye Z, Ai X, Yang K, Yang Z, Fei F, Liao X, Qiu Z, Gimple RC, Yuan H, Huang H, Gong Y, Xiao C, Yue J, Huang L, Saulnier O, Wang W, Zhang P, Dai L, Wang X, Wang X, Ahn YH, You C, Xu J, Wan X, Taylor MD, Zhao L, Rich JN, Zhou S
Cancer discovery 2023 Apr 3;13(4):974-1001

Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.

Li J, Yang T, Wang Q, Li Y, Wu H, Zhang M, Qi H, Zhang H, Li J
International journal of biological sciences 2022;18(9):3576-3591

Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.

Li MT, Liu LL, Zhou Q, Huang LX, Shi YX, Hou JB, Lu HT, Yu B, Chen W, Guo ZY
Frontiers in pharmacology 2022;13:891788

SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma.

You W, Ke J, Chen Y, Cai Z, Huang ZP, Hu P, Wu X
Frontiers in immunology 2022;13:864244

Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer.

Shangguan X, Ma Z, Yu M, Ding J, Xue W, Qi J
Cancer research 2022 Sep 2;82(17):3032-3044

Terbinafine prevents colorectal cancer growth by inducing dNTP starvation and reducing immune suppression.

Hu LP, Huang W, Wang X, Xu C, Qin WT, Li D, Tian G, Li Q, Zhou Y, Chen S, Nie HZ, Hao Y, Song J, Zhang XL, Sundquist J, Sundquist K, Li J, Jiang SH, Zhang ZG, Ji J
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Oct 5;30(10):3284-3299

AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.

Sheng N, Wang YQ, Wang CF, Jia MQ, Niu HM, Lu QQ, Wang YN, Feng D, Zheng XX, Yuan HQ
Acta pharmacologica Sinica 2022 Nov;43(11):2905-2916

Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages.

Wang Y, Wang Y, Ding L, Ren X, Wang B, Wang L, Zhao S, Yue X, Wu Z, Li C, Liang X, Ma C, Gao L
Cell reports 2022 Nov 29;41(9):111738

ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins.

McKenna MJ, Adams BM, Chu V, Paulo JA, Shao S
Molecular cell 2022 Nov 17;82(22):4277-4289.e10

Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.

Guo C, Wan R, He Y, Lin SH, Cao J, Qiu Y, Zhang T, Zhao Q, Niu Y, Jin Y, Huang HY, Wang X, Tan L, Thomas RK, Zhang H, Chen L, Wong KK, Hu L, Ji H
Nature cancer 2022 May;3(5):614-628

Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression.

Gouirand V, Gicquel T, Lien EC, Jaune-Pons E, Da Costa Q, Finetti P, Metay E, Duluc C, Mayers JR, Audebert S, Camoin L, Borge L, Rubis M, Leca J, Nigri J, Bertucci F, Dusetti N, Iovanna JL, Tomasini R, Bidaut G, Guillaumond F, Vander Heiden MG, Vasseur S
The EMBO journal 2022 May 2;41(9):e110466

Squalene synthase predicts poor prognosis in stage I-III colon adenocarcinoma and synergizes squalene epoxidase to promote tumor progression.

Jiang H, Tang E, Chen Y, Liu H, Zhao Y, Lin M, He L
Cancer science 2022 Mar;113(3):971-985

SQLE inhibition suppresses the development of pancreatic ductal adenocarcinoma and enhances its sensitivity to chemotherapeutic agents in vitro.

Zhao F, Huang Y, Zhang Y, Li X, Chen K, Long Y, Li F, Ma X
Molecular biology reports 2022 Jul;49(7):6613-6621

Hibiscus syriacus L. cultivated in callus culture exerts cytotoxicity in colorectal cancer via Notch signaling-mediated cholesterol biosynthesis suppression.

Xu XY, Choi HS, Park SY, Kim JK, Seo KH, Kim H, Kim YJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153870

Downregulated ferroptosis-related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastoma.

Yao L, Li J, Zhang X, Zhou L, Hu K
CNS neuroscience & therapeutics 2022 Dec;28(12):2104-2115

Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.

Ho GY, Kyran EL, Bedo J, Wakefield MJ, Ennis DP, Mirza HB, Vandenberg CJ, Lieschke E, Farrell A, Hadla A, Lim R, Dall G, Vince JE, Chua NK, Kondrashova O, Upstill-Goddard R, Bailey UM, Dowson S, Roxburgh P, Glasspool RM, Bryson G, Biankin AV, Scottish Genomes Partnership, Cooke SL, Ratnayake G, McNally O, Traficante N, Australian Ovarian Cancer Study12,13, DeFazio A, Weroha SJ, Bowtell DD, McNeish IA, Papenfuss AT, Scott CL, Barker HE
Cancer research 2022 Dec 2;82(23):4457-4473

Comparative analysis of transient receptor potential channel 5 opposite strand-induced gene expression patterns and protein-protein interactions in triple-negative breast cancer.

Peng J, Pei S, Cui Y, Xia Y, Huang Y, Wu X, Zheng M, Weng M, Han X, Fu H, Yang L, Zhou W, Fu Z, Wang S, Xie H
Oncology letters 2022 Aug;24(2):259

Acetyl-CoA Deficiency Is Involved in the Regulation of Iron Overload on Lipid Metabolism in Apolipoprotein E Knockout Mice.

Luo G, Xiang L, Xiao L
Molecules (Basel, Switzerland) 2022 Aug 4;27(15)

Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy.

Hong Z, Liu T, Wan L, Fa P, Kumar P, Cao Y, Prasad CB, Qiu Z, Liu J, Wang H, Li Z, Wang QE, Guo P, Guo D, Yilmaz AS, Lu L, Papandreou I, Jacob NK, Yan C, Zhang X, She QB, Ma Z, Zhang J
Cancer research 2022 Apr 1;82(7):1298-1312

A Novel Ferroptosis-Related Prognostic Signature Reveals Macrophage Infiltration and EMT Status in Bladder Cancer.

Yan Y, Cai J, Huang Z, Cao X, Tang P, Wang Z, Zhang F, Xia S, Shen B
Frontiers in cell and developmental biology 2021;9:712230

MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE.

Yang F, Kou J, Liu Z, Li W, Du W
Frontiers in cell and developmental biology 2021;9:655889

High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma.

Liu Y, Fang L, Liu W
Cancer management and research 2021;13:4709-4723

p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth.

Sun H, Li L, Li W, Yang F, Zhang Z, Liu Z, Du W
EMBO reports 2021 Oct 5;22(10):e52537

HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis.

Zhang Z, Wen H, Peng B, Weng J, Zeng F
Molecular therapy. Nucleic acids 2021 Jun 4;24:711-727

The antiviral enzyme viperin inhibits cholesterol biosynthesis.

Grunkemeyer TJ, Ghosh S, Patel AM, Sajja K, Windak J, Basrur V, Kim Y, Nesvizhskii AI, Kennedy RT, Marsh ENG
The Journal of biological chemistry 2021 Jul;297(1):100824

The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active form.

Coates HW, Capell-Hattam IM, Brown AJ
The Journal of biological chemistry 2021 Jan-Jun;296:100731

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1-mediated MAPK signaling.

He L, Li H, Pan C, Hua Y, Peng J, Zhou Z, Zhao Y, Lin M
Cancer communications (London, England) 2021 Aug;41(8):726-746

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer.

Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson MT, Schmitz W, Wach S, Krebs M, Hartmann E, Puhr M, Müller A, Spahn M, Seitz AK, Frank T, Marouf H, Büchel G, Eckstein M, Kübler H, Eilers M, Saar M, Junker K, Röhrig F, Kneitz B, Rosenfeldt MT, Schulze A
Nature communications 2021 Aug 20;12(1):5066

The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.

Scott NA, Sharpe LJ, Capell-Hattam IM, Gullo SJ, Luu W, Brown AJ
The Biochemical journal 2020 Jan 31;477(2):541-555

Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism.

Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, Wang Z, Yang S, Tang W, Zhen J, Li Y, Wang X, Liu M, Zhang Y, Wang B, Liu G, Yu X, Sun J, Zhang C, Yi F
Cell metabolism 2020 Dec 1;32(6):1052-1062.e8

The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting.

Tan JME, van der Stoel MM, van den Berg M, van Loon NM, Moeton M, Scholl E, van der Wel NN, Kovačević I, Hordijk PL, Loregger A, Huveneers S, Zelcer N
Cell reports 2020 Aug 4;32(5):107944

Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron.

Chua NK, Scott NA, Brown AJ
The Biochemical journal 2019 Sep 20;476(18):2545-2560

OSBPL2 deficiency upregulate SQLE expression increasing intracellular cholesterol and cholesteryl ester by AMPK/SP1 and SREBF2 signalling pathway.

Zhang C, Zhang H, Zhang M, Lin C, Wang H, Yao J, Wei Q, Lu Y, Chen Z, Xing G, Cao X
Experimental cell research 2019 Oct 15;383(2):111512

Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum.

Honsho M, Dorninger F, Abe Y, Setoyama D, Ohgi R, Uchiumi T, Kang D, Berger J, Fujiki Y
Journal of biochemistry 2019 Oct 1;166(4):353-361

Consulting prostate cancer cohort data uncovers transcriptional control: Regulation of the MARCH6 gene.

Coates HW, Chua NK, Brown AJ
Biochimica et biophysica acta. Molecular and cell biology of lipids 2019 Nov;1864(11):1656-1668

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death.

Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, Birsoy K
Nature 2019 Mar;567(7746):118-122

FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB.

Pronk MCA, Majolée J, Loregger A, van Bezu JSM, Zelcer N, Hordijk PL, Kovačević I
Molecular biology of the cell 2019 Mar 1;30(5):607-621

N-terminal acetylation and the N-end rule pathway control degradation of the lipid droplet protein PLIN2.

Nguyen KT, Lee CS, Mun SH, Truong NT, Park SK, Hwang CS
The Journal of biological chemistry 2019 Jan 4;294(1):379-388

The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis.

Volkmar N, Thezenas ML, Louie SM, Juszkiewicz S, Nomura DK, Hegde RS, Kessler BM, Christianson JC
Journal of cell science 2019 Jan 16;132(2)

Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue.

Werner E, Alter A, Deng Q, Dammer EB, Wang Y, Yu DS, Duong DM, Seyfried NT, Doetsch PW
Scientific reports 2019 Aug 29;9(1):12546

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.

Stefanovic-Barrett S, Dickson AS, Burr SP, Williamson JC, Lobb IT, van den Boomen DJ, Lehner PJ, Nathan JA
EMBO reports 2018 May;19(5)

Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.

Loregger A, Raaben M, Tan J, Scheij S, Moeton M, van den Berg M, Gelberg-Etel H, Stickel E, Roitelman J, Brummelkamp T, Zelcer N
Arteriosclerosis, thrombosis, and vascular biology 2017 Nov;37(11):2064-2074

Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia.

Haider S, McIntyre A, van Stiphout RG, Winchester LM, Wigfield S, Harris AL, Buffa FM
Genome biology 2016 Jun 29;17(1):140

A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.

Loregger A, Cook EC, Nelson JK, Moeton M, Sharpe LJ, Engberg S, Karimova M, Lambert G, Brown AJ, Zelcer N
Molecular and cellular biology 2016 Jan 15;36(2):285-94

Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.

Honsho M, Abe Y, Fujiki Y
The Journal of biological chemistry 2015 Nov 27;290(48):28822-33

The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.

Zelcer N, Sharpe LJ, Loregger A, Kristiana I, Cook EC, Phan L, Stevenson J, Brown AJ
Molecular and cellular biology 2014 Apr;34(7):1262-70

Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function.

Suzuki R, Ferris HA, Chee MJ, Maratos-Flier E, Kahn CR
PLoS biology 2013;11(4):e1001532

Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4.

Foresti O, Ruggiano A, Hannibal-Bach HK, Ejsing CS, Carvalho P
eLife 2013 Jul 23;2:e00953

Cholesterol through the looking glass: ability of its enantiomer also to elicit homeostatic responses.

Kristiana I, Luu W, Stevenson J, Cartland S, Jessup W, Belani JD, Rychnovsky SD, Brown AJ
The Journal of biological chemistry 2012 Sep 28;287(40):33897-904

Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.

Gill S, Stevenson J, Kristiana I, Brown AJ
Cell metabolism 2011 Mar 2;13(3):260-73

Diabetes and insulin in regulation of brain cholesterol metabolism.

Suzuki R, Lee K, Jing E, Biddinger SB, McDonald JG, Montine TJ, Craft S, Kahn CR
Cell metabolism 2010 Dec 1;12(6):567-79

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: A549 cells were subjected to SDS PAGE followed by western blot with 12544-1-AP(SQLE antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SQLE antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human SQLE. This antibody recognizes human,mouse,rat antigen. The SQLE antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 12544-1-AP.pdf

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