CD2BP2

This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]

Description

CD2 cytoplasmic tail binding protein 2

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (30350773 - 30355308)

Ensembl ID

ENSG00000169217  (ver. 103.38)

Orthologs

Mouse Cd2bp2: ENSMUSG00000042502

UniProt

O95400

neXtProt

NX_O95400

Human splice variants
Mouse splice variants

Protein structure