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- References [29]
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- Product number
- 21445-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- DDRGK1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DDRGK1 antibody (Cat. #21445-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The UFMylation pathway is impaired in Alzheimer's disease.
UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity.
CDK5RAP3 is a novel super-enhancer-driven gene activated by master TFs and regulates ER-Phagy in neuroblastoma.
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia.
Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress.
UFMylation of HRD1 regulates endoplasmic reticulum homeostasis.
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination.
Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control.
A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila.
Deficiency of Murine UFM1-Specific E3 Ligase Causes Microcephaly and Inflammation.
A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation.
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.
Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation.
A pathogenic UFSP2 variant in an autosomal recessive form of pediatric neurodevelopmental anomalies and epilepsy.
Ufmylation regulates granulosa cell apoptosis via ER stress but not oxidative stress during goat follicular atresia.
Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination.
A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.
UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis.
UFMylation is associated with LPS-induced inflammatory response in goat endometrial epithelial cells.
Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation.
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Salubrinal, a novel inhibitor of eIF-2α dephosphorylation, promotes erythropoiesis at early stage targeted by ufmylation pathway.
Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer.
Proteomic and Biochemical Analyses Reveal a Novel Mechanism for Promoting Protein Ubiquitination and Degradation by UFBP1, a Key Component of Ufmylation.
A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability.
Yan T, Heckman MG, Craver EC, Liu CC, Rawlinson BD, Wang X, Murray ME, Dickson DW, Ertekin-Taner N, Lou Z, Bu G, Springer W, Fiesel FC
bioRxiv : the preprint server for biology 2024 May 26;
bioRxiv : the preprint server for biology 2024 May 26;
UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
DaRosa PA, Penchev I, Gumbin SC, Scavone F, Wąchalska M, Paulo JA, Ordureau A, Peter JJ, Kulathu Y, Harper JW, Becker T, Beckmann R, Kopito RR
Nature 2024 Mar;627(8003):445-452
Nature 2024 Mar;627(8003):445-452
UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity.
He C, Xing X, Chen HY, Gao M, Shi J, Xiang B, Xiao X, Sun Y, Yu H, Xu G, Yao Y, Xie Z, Xing Y, Budiarto BR, Chen SY, Gao Y, Lee YR, Zhang J
Molecular cell 2024 Mar 21;84(6):1120-1138.e8
Molecular cell 2024 Mar 21;84(6):1120-1138.e8
CDK5RAP3 is a novel super-enhancer-driven gene activated by master TFs and regulates ER-Phagy in neuroblastoma.
Zhuo R, Zhang Z, Chen Y, Li G, Du S, Guo X, Yang R, Tao Y, Li X, Fang F, Xie Y, Wu D, Yang Y, Yang C, Yin H, Qian G, Wang H, Yu J, Jia S, Zhu F, Feng C, Wang J, Xu Y, Li Z, Shi L, Wang X, Pan J, Wang J
Cancer letters 2024 Jun 1;591:216882
Cancer letters 2024 Jun 1;591:216882
Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia.
Yang X, Zhou T, Wang X, Xia Y, Cao X, Cheng X, Cao Y, Ma P, Ma H, Qin A, Zhao J
International journal of biological sciences 2023;19(15):4709-4725
International journal of biological sciences 2023;19(15):4709-4725
Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress.
Mao Z, Ma X, Jing Y, Shen M, Ma X, Zhu J, Liu H, Zhang G, Chen F
Cell death & disease 2023 Sep 2;14(9):584
Cell death & disease 2023 Sep 2;14(9):584
UFMylation of HRD1 regulates endoplasmic reticulum homeostasis.
Luo H, Jiao QB, Shen CB, Gong WY, Yuan JH, Liu YY, Chen Z, Liu J, Xu XL, Cong YS, Zhang XW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23221
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Nov;37(11):e23221
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination.
Wang X, Zhou T, Yang X, Cao X, Jin G, Zhang P, Guo J, Rong K, Li B, Hu Y, Liu K, Ma P, Qin A, Zhao J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2204438
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2204438
Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.
Deng H, Chen W, Zhang B, Zhang Y, Han L, Zhang Q, Yao S, Wang H, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control.
Ishimura R, Ito S, Mao G, Komatsu-Hirota S, Inada T, Noda NN, Komatsu M
Science advances 2023 Aug 18;9(33):eadh3635
Science advances 2023 Aug 18;9(33):eadh3635
A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila.
Li H, Yu Z, Niu Z, Cheng Y, Wei Z, Cai Y, Ma F, Hu L, Zhu J, Zhang W
Cellular and molecular life sciences : CMLS 2023 Apr 22;80(5):129
Cellular and molecular life sciences : CMLS 2023 Apr 22;80(5):129
Deficiency of Murine UFM1-Specific E3 Ligase Causes Microcephaly and Inflammation.
Zhang J, Zhu H, Liu S, Quintero M, Zhu T, Xu R, Cai Y, Han Y, Li H
Molecular neurobiology 2022 Oct;59(10):6363-6372
Molecular neurobiology 2022 Oct;59(10):6363-6372
A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation.
Peter JJ, Magnussen HM, DaRosa PA, Millrine D, Matthews SP, Lamoliatte F, Sundaramoorthy R, Kopito RR, Kulathu Y
The EMBO journal 2022 Nov 2;41(21):e111015
The EMBO journal 2022 Nov 2;41(21):e111015
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.
Ishimura R, El-Gowily AH, Noshiro D, Komatsu-Hirota S, Ono Y, Shindo M, Hatta T, Abe M, Uemura T, Lee-Okada HC, Mohamed TM, Yokomizo T, Ueno T, Sakimura K, Natsume T, Sorimachi H, Inada T, Waguri S, Noda NN, Komatsu M
Nature communications 2022 Dec 21;13(1):7857
Nature communications 2022 Dec 21;13(1):7857
Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation.
Chen F, Sheng L, Xu C, Li J, Ali I, Li H, Cai Y
Frontiers in cell and developmental biology 2021;9:676789
Frontiers in cell and developmental biology 2021;9:676789
A pathogenic UFSP2 variant in an autosomal recessive form of pediatric neurodevelopmental anomalies and epilepsy.
Ni M, Afroze B, Xing C, Pan C, Shao Y, Cai L, Cantarel BL, Pei J, Grishin NV, Hewson S, Knight D, Mahida S, Michel D, Tarnopolsky M, Poduri A, Rotenberg A, Sondheimer N, DeBerardinis RJ
Genetics in medicine : official journal of the American College of Medical Genetics 2021 May;23(5):900-908
Genetics in medicine : official journal of the American College of Medical Genetics 2021 May;23(5):900-908
Ufmylation regulates granulosa cell apoptosis via ER stress but not oxidative stress during goat follicular atresia.
Zhang X, Yu T, Guo X, Zhang R, Jia Y, Shang C, Wang A, Jin Y, Lin P
Theriogenology 2021 Jul 15;169:47-55
Theriogenology 2021 Jul 15;169:47-55
Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
Quintero M, Liu S, Xia Y, Huang Y, Zou Y, Li G, Hu L, Singh N, Blumberg R, Cai Y, Xu H, Li H
Cell death & disease 2021 Jan 27;12(1):131
Cell death & disease 2021 Jan 27;12(1):131
DDRGK1, a crucial player of ufmylation system, is indispensable for autophagic degradation by regulating lysosomal function.
Cao Y, Li R, Shen M, Li C, Zou Y, Jiang Q, Liu S, Lu C, Li H, Liu H, Cai Y
Cell death & disease 2021 Apr 20;12(5):416
Cell death & disease 2021 Apr 20;12(5):416
UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination.
Liu J, Guan D, Dong M, Yang J, Wei H, Liang Q, Song L, Xu L, Bai J, Liu C, Mao J, Zhang Q, Zhou J, Wu X, Wang M, Cong YS
Nature cell biology 2020 Sep;22(9):1056-1063
Nature cell biology 2020 Sep;22(9):1056-1063
A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.
Liang JR, Lingeman E, Luong T, Ahmed S, Muhar M, Nguyen T, Olzmann JA, Corn JE
Cell 2020 Mar 19;180(6):1160-1177.e20
Cell 2020 Mar 19;180(6):1160-1177.e20
UFMylation of RPL26 links translocation-associated quality control to endoplasmic reticulum protein homeostasis.
Wang L, Xu Y, Rogers H, Saidi L, Noguchi CT, Li H, Yewdell JW, Guydosh NR, Ye Y
Cell research 2020 Jan;30(1):5-20
Cell research 2020 Jan;30(1):5-20
UFMylation is associated with LPS-induced inflammatory response in goat endometrial epithelial cells.
Xiao J, Liu S, Yu T, Zhang R, Guo X, Jia Y, Shang C, Wang A, Jin Y, Lin P
Reproduction in domestic animals = Zuchthygiene 2020 Dec;55(12):1725-1734
Reproduction in domestic animals = Zuchthygiene 2020 Dec;55(12):1725-1734
Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation.
Cai Y, Zhu G, Liu S, Pan Z, Quintero M, Poole CJ, Lu C, Zhu H, Islam B, Riggelen JV, Browning D, Liu K, Blumberg R, Singh N, Li H
Cell discovery 2019;5:7
Cell discovery 2019;5:7
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina SK, Patel N, Savage NM, Sharma A, Kaufman RJ, Li H, Singh N
Nature communications 2019 Mar 6;10(1):1084
Nature communications 2019 Mar 6;10(1):1084
Salubrinal, a novel inhibitor of eIF-2α dephosphorylation, promotes erythropoiesis at early stage targeted by ufmylation pathway.
Chen F, Xing C, Zhang W, Li J, Hu T, Li L, Li H, Cai Y
Journal of cellular physiology 2019 Aug;234(10):18560-18570
Journal of cellular physiology 2019 Aug;234(10):18560-18570
Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer.
Lin JX, Xie XS, Weng XF, Zheng CH, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Li P, Huang CM
World journal of gastroenterology 2018 Sep 14;24(34):3898-3907
World journal of gastroenterology 2018 Sep 14;24(34):3898-3907
Proteomic and Biochemical Analyses Reveal a Novel Mechanism for Promoting Protein Ubiquitination and Degradation by UFBP1, a Key Component of Ufmylation.
Zhu Y, Lei Q, Li D, Zhang Y, Jiang X, Hu Z, Xu G
Journal of proteome research 2018 Apr 6;17(4):1509-1520
Journal of proteome research 2018 Apr 6;17(4):1509-1520
A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1α stability.
Liu J, Wang Y, Song L, Zeng L, Yi W, Liu T, Chen H, Wang M, Ju Z, Cong YS
Nature communications 2017 Jan 27;8:14186
Nature communications 2017 Jan 27;8:14186
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The DDRGK1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human DDRGK1. This antibody recognizes human, mouse antigen. The DDRGK1 antibody has been validated for the following applications: ELISA, WB analysis.
