11334-1-AP

antibody from Proteintech Group

Targeting: PTPN1 PTP1B

Provider product page for 11334-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [55]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 11334-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11334-1-AP, RRID:AB_10642566
Product name: PTP1B antibody
Antibody type: Polyclonal
Description: KD/KO validated PTP1B antibody (Cat. #11334-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PTPN1 protein structure - 11334-1-AP shown in red.

Submitted references Cinnamaldehyde inhibits the progression of gastric cancer by regulating glycolysis through PTP1B/PI3K/AKT/mTOR signaling pathway.

Qiao X, Xue D, Hu Z, Wang H, Mu L
Toxicology and applied pharmacology 2026 May;510:117775

HMBOX1 inhibits hepatocellular carcinoma progression via PTPN1 mediated AKT1 phosphorylation.

Zhang C, Jiang Y, Liu J, Zhang W, Qi J, Wen Q, Zhao H
Oncology reports 2026 Mar;55(3)

Zedoarondiol regulates steatosis and inflammation in alcoholic liver injury via PTP1B-target mechanisms.

Zhu J, Wang H, Tang Z, Yan X, Dong J, Ye C, Wu Y, Guo T, Jin Z, Zhang Y, Huang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158132

Role of PTP1B in coordinating synaptic plasticity and ferroptosis: A mechanism underlying the antidepressant effect of spinosin from Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou.

Wang Y, Zhang Y, Wang J, Wu X, Li Y, Sun W, Song L, Gong M, He Q, Qin L, Wang Q, Ji L, Zhang T
Journal of ethnopharmacology 2026 Jun 12;364:121428

The CHPT-pSTAT3-SLC7A11 signaling axis controls progression and ferroptosis susceptibility of pancreatic cancer.

Yang J, Liu J, Rong Z, Tan Z, Wang W, Meng Q, Wei M, Hua J, Zhang B, Yu X, Xu J, Liang C
Translational oncology 2026 Jan;63:102624

Roburic acid inhibits glucocorticoid-induced osteonecrosis of the femoral head associated osteoclast activity via targeting PTP1B.

Wang G, Mo L, Wang C, Zhang Y, Li Y, Yuan J, Jin H, Chen P, Chen D, Zhou J, He W, Xu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157961

Hepatic ASPG-mediated lysophosphatidylinositol catabolism impairs insulin signal transduction.

Li F, Huang HS, Zhao Q, Zhang W, Shi T, Lv W, Zhu Q, Liu H, Xu Y, Huang H, Tang QQ, Gao Y, Peng T, Pan D
The EMBO journal 2025 Sep;44(18):5005-5036

(20S)-protopanaxatriol attenuates Ang II-induced renal injury via PTPN1-mediated AMPK/mTOR signaling pathway.

Zhao R, Wang Z, Liu C, Zhang L, Zhang M, Du H, Yang G, Sun H, Liu W, Yan S, Wang M
Journal of ginseng research 2025 Nov;49(6):652-662

The m(6)A demethylase FTO links TLR7 to mitochondrial oxidation driving age-associated B cell formation in systemic lupus erythematosus.

Zeng Q, Li L, Li X, Qin L, Feng T, Zhu Y, Wang J, Zou Y, Su J, Dong G, Xia W, Xu T, Zhang G, Cui Y, Lin H, Li X, Li Y
Science translational medicine 2025 Nov 5;17(823):eadu6015

WTAP-mediated m(6)A modification of PTPN1 contributes to ulcerative colitis pathogenesis through regulating colonic epithelial cell phenotypes.

Zhang Y, Li N, Zhang D, Zhang H
Human cell 2025 Nov 10;39(1):3

PTEN protein phosphatase activity regulates metastasis by targeting PKCδ.

Yu Y, Zhao M, Buenaventura RGM, Merlino G
iScience 2025 Jun 20;28(6):112741

Identification of novel PTP1B inhibitor for the treatment of LPS-induced myocardial apoptosis: machine learning based virtual screening and biological evaluation.

Dong X, Shang B, Li X, Zhang J, Liu Z, Feng B
Journal of enzyme inhibition and medicinal chemistry 2025 Dec;40(1):2596950

Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca(2+) Imbalance.

Zhang Z, Zhang J, Li L, Zong L
Molecular neurobiology 2025 Dec 5;63(1):256

Salvia miltiorrhiza Bge extract ameliorates abnormalities in glycolipid metabolism in db/db mice by regulating tyrosine metabolism through PTP1B/IRS-1/AKT signaling pathway.

Zhang Z, Zeng M, Guo P, Zhang Y, Ye K, Sun J, Wang Y, Chang F, Zheng X, Feng W
Journal of ethnopharmacology 2025 Aug 29;352:120236

Discovery of novel oleanolic acid glycoside derivatives targeting PTP1B/PI3K/AKT signaling pathway for the treatment of breast cancer.

Song X, Wang L, Liu Y, Xu K, Cai P, Liu J, Liu Q, Fan D
Bioorganic chemistry 2025 Apr;157:108296

Farrerol alleviates insulin resistance and hepatic steatosis of metabolic associated fatty liver disease by targeting PTPN1.

Gao J, Cang X, Liu L, Lin J, Zhu S, Liu L, Liu X, Zhu J, Xu C
Journal of cellular and molecular medicine 2024 Sep;28(18):e70096

Baicalein Ameliorates Insulin Resistance of HFD/STZ Mice Through Activating PI3K/AKT Signal Pathway of Liver and Skeletal Muscle in a GLP-1R-Dependent Manner.

Liu N, Cui X, Guo T, Wei X, Sun Y, Liu J, Zhang Y, Ma W, Yan W, Chen L
Antioxidants (Basel, Switzerland) 2024 Oct 16;13(10)

PTP1B Modulates Carotid Plaque Vulnerability in Atherosclerosis Through Rab5-PDGFRβ-Mediated Endocytosis Disruption and Apoptosis.

Zhang X, Xu R, Wang T, Li J, Sun Y, Cui S, Xing Z, Lyu X, Yang G, Jiao L, Li W
CNS neuroscience & therapeutics 2024 Nov;30(11):e70071

Lanostane triterpenoids from Ganoderma calidophilum exhibit potent anti-tumor activity by inhibiting PTP1B.

Chen C, Xu R, Guo C, Li X, Zhao Y, Luo D
Chemico-biological interactions 2024 Nov 1;403:111253

Ficolin 3 promotes ferroptosis in HCC by downregulating IR/SREBP axis-mediated MUFA synthesis.

Yuan Y, Xu J, Jiang Q, Yang C, Wang N, Liu X, Piao HL, Lu S, Zhang X, Han L, Liu Z, Cai J, Liu F, Chen S, Liu J
Journal of experimental & clinical cancer research : CR 2024 May 3;43(1):133

Ursonic acid from medicinal herbs inhibits PRRSV replication through activation of the innate immune response by targeting the phosphatase PTPN1.

Yang Y, Gao Y, Sun H, Bai J, Zhang J, Zhang L, Liu X, Sun Y, Jiang P
Veterinary research 2024 May 23;55(1):67

A Novel Role for Protein Tyrosine Phosphatase 1B in Alleviating Chondrocyte Senescence.

Li HM, Che X, Tong Z, Wei W, Teng C
ACS omega 2024 Jun 25;9(25):27017-27029

Upregulation of PTPN1 aggravates endotoxemia-induced cardiac dysfunction through inhibiting mitophagy.

Song Q, Ma H, Zhu L, Qi Z, Lan Z, Liu K, Zhang H, Wang K, Wang N
International immunopharmacology 2024 Jan 5;126:111315

Ginsenoside F4 Alleviates Skeletal Muscle Insulin Resistance by Regulating PTP1B in Type II Diabetes Mellitus.

Zhao Y, Liu Y, Deng J, Zhu C, Ma X, Jiang M, Fan D
Journal of agricultural and food chemistry 2023 Oct 4;71(39):14263-14275

Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice.

Zhang ZH, Zhou XM, Zhang X
Brain sciences 2023 May 18;13(5)

Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation.

Fu J, Yu L, Yu Q, Yu N, Xu F, Li S
Journal of ginseng research 2023 Mar;47(2):274-282

Curcumin inhibits proliferation of hepatocellular carcinoma cells by blocking PTPN1 and PTPN11 expression.

Zhang J, Liu Y, Wang X, Wang Z, Xing E, Li J, Wang D
Oncology letters 2023 Jul;26(1):307

Efficacy of Young Cinnamomum zeylanicum Blume Bark on Hyperglycemia and PTPase Activity in Type 2 Diabetes.

Mandal A, Sharma SK, Yadav SRM, Mirza AA, Thakur MS, Jachak S, Saini S, Roy P, Kant R, Patil M
Cureus 2023 Feb;15(2):e35023

HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.

Liu Y, Xu Q, Deng F, Zheng Z, Luo J, Wang P, Zhou J, Lu X, Zhang L, Chen Z, Zhang Q, Chen Q, Zuo D
Journal of experimental & clinical cancer research : CR 2023 Feb 1;42(1):38

A Theranostic Small-Molecule Prodrug Conjugate for Neuroendocrine Prostate Cancer.

Gonzalez P, Debnath S, Chen YA, Hernandez E, Jha P, Dakanali M, Hsieh JT, Sun X
Pharmaceutics 2023 Feb 1;15(2)

Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway.

Wang AH, Ma HY, Yi YL, Zhu SJ, Yu ZW, Zhu J, Mei S, Bahetibike S, Lu YQ, Huang LT, Yang RY, Rui-Wang, Xiao SL, Qi R
European journal of pharmacology 2023 Dec 5;960:176116

BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.

Jin J, He Y, Guo J, Pan Q, Wei X, Xu C, Qi Z, Li Q, Ma S, Lin J, Jiang N, Ma J, Wang X, Jiang L, Ding Q, Osto E, Zhi X, Meng D
Nature communications 2023 Dec 21;14(1):8428

GPx1 promotes hypertrophic differentiation of chondrocytes through modulation of akt signaling in a non-monotonic manner.

Mi S, Zhang J, Sun M, Huo X, Lv Y, Beier F, Lu S, Yan J
Experimental cell research 2023 Dec 15;433(2):113824

Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance.

Gao X, Wu Y, Chick JM, Abbott A, Jiang B, Wang DJ, Comte-Walters S, Johnson RH, Oberholtzer N, Nishimura MI, Gygi SP, Mehta A, Guttridge DC, Ball L, Mehrotra S, Sicinski P, Yu XZ, Wang H
Cell reports 2023 Apr 25;42(4):112314

Multi-omics analyses of tumor-associated immune-infiltrating cells with the novel immune checkpoint protein tyrosine phosphatase 1B (PTP1B) in extracellular matrix of brain-lower-grade-glioma (LGG) and uveal-melanoma (UVM).

Bai KH, Zhu MJ, Zhang YY, Li XP, Chen SL, Wang DW, Dai YJ
Frontiers in immunology 2022;13:1053856

MiR-135a-5p suppresses trophoblast proliferative, migratory, invasive, and angiogenic activity in the context of unexplained spontaneous abortion.

Lu Y, Zhang X, Li X, Deng L, Wei C, Yang D, Tan X, Pan W, Pang L
Reproductive biology and endocrinology : RB&E 2022 May 24;20(1):82

Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance.

Wang Y, Xiong J, Yuan Y, Peng C, Wu P, Wang Y, Lu J, Yin Y, Xu J, Chen S, Liu J
Obesity (Silver Spring, Md.) 2022 Mar;30(3):680-693

Endotoxin tolerance induced by Porphyromonas gingivalis lipopolysaccharide alters macrophage polarization.

Gu JY, Fu ZB, Jia-Lu Chen, Liu YJ, Cao XZ, Sun Y
Microbial pathogenesis 2022 Mar;164:105448

Protein tyrosine phosphatase 1B regulates fibroblasts proliferation, motility and extracellular matrix synthesis via the MAPK/ERK signalling pathway in keloid.

Qian L, Wang Q, Wei C, Wang L, Yang Y, Deng X, Liu J, Qi F
Experimental dermatology 2022 Feb;31(2):202-213

PLXDC2 enhances invadopodium formation to promote invasion and metastasis of gastric cancer cells via interacting with PTP1B.

Wu B, Wang YX, Wang JJ, Xiang DF, Zhang MS, Yan ZX, Wang WY, Miao JY, Lan X, Liu JJ, Li ZY, Li C, Fan JY, Liu JY, Jiang L, Xu SL, Cui YH, Qian F
Clinical & experimental metastasis 2022 Aug;39(4):691-710

Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation.

Wu J, Xue X, Fan G, Gu Y, Zhou F, Zheng Q, Liu R, Li Y, Ma B, Li S, Huang G, Ma L, Li X
Frontiers in pharmacology 2021;12:754976

Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis.

Takaoka S, Yanagiya A, Mohamed HMA, Higa R, Abe T, Inoue KI, Takahashi A, Stoney P, Yamamoto T
iScience 2021 Oct 22;24(10):103151

The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy.

Huang T, Li X, Wang F, Lu L, Hou W, Zhu M, Miao C
Cell death & disease 2021 Mar 29;12(4):333

Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma.

Du J, Dong Z, Tan L, Tan M, Zhang F, Zhang K, Pan G, Li C, Shi S, Zhang Y, Liu Y, Cui H
Frontiers in cell and developmental biology 2020;8:607757

Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo.

Feng CW, Chen NF, Chan TF, Chen WF
Parkinson's disease 2020;2020:8814236

Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p.

Yao QP, Liu Z, Yao AH, Liu JT, Jiang J, Chen Y, Li SS, Han Y, Jiang ZL, Qi YX
Journal of cellular physiology 2020 Oct;235(10):6831-6842

CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.

Chen Y, Tang J, Lu T, Liu F
Thoracic cancer 2020 Jul;11(7):1848-1860

PTP1B promotes macrophage activation by regulating the NF-κB pathway in alcoholic liver injury.

Yang L, Sun YY, Liu YR, Yin NN, Bu FT, Yu HX, Du XS, Li J, Huang C
Toxicology letters 2020 Feb 1;319:11-21

Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells.

Shi C, Yang J, Hu L, Liao B, Qiao L, Shen W, Xie F, Zhu G
Aging 2020 Aug 3;12(15):15546-15555

Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR.

Yang P, Zeng H, Tan W, Luo X, Zheng E, Zhao L, Wei L, Ruan XZ, Chen Y, Chen Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5658-5672

Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.

Li C, Luo J, Guo S, Jia X, Guo C, Li X, Xu Q, Shi D
Molecular pharmaceutics 2019 May 6;16(5):1839-1850

Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.

Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N
Cells 2019 May 31;8(6)

HDAC6 interacts with PTPN1 to enhance melanoma cells progression.

Liu J, Luan W, Zhang Y, Gu J, Shi Y, Yang Y, Feng Z, Qi F
Biochemical and biophysical research communications 2018 Jan 22;495(4):2630-2636

Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.

Xiang M, Su H, Hong Z, Yang T, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71

A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.

Liu YZ, Jiang YY, Wang BS, Hao JJ, Shang L, Zhang TT, Cao J, Xu X, Zhan QM, Wang MR
Cancer cytopathology 2014 Nov;122(11):833-41

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 11334-1-AP(PTPN1 antibody) at dilution of 1:300
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PTP1B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PTP1B. This antibody recognizes human,mouse,rat antigen. The PTP1B antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11334-1-AP.pdf

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