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- Antigen structure
- References [15]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 11334-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11334-1-AP, RRID:AB_10642566
- Product name
- PTP1B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PTP1B antibody (Cat. #11334-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation.
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis.
The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy.
Protein tyrosine phosphatase 1B regulates fibroblasts proliferation, motility and extracellular matrix synthesis via the MAPK/ERK signalling pathway in keloid.
Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma.
Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo.
Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p.
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
PTP1B promotes macrophage activation by regulating the NF-κB pathway in alcoholic liver injury.
Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells.
Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR.
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
HDAC6 interacts with PTPN1 to enhance melanoma cells progression.
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
Wu J, Xue X, Fan G, Gu Y, Zhou F, Zheng Q, Liu R, Li Y, Ma B, Li S, Huang G, Ma L, Li X
Frontiers in pharmacology 2021;12:754976
Frontiers in pharmacology 2021;12:754976
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis.
Takaoka S, Yanagiya A, Mohamed HMA, Higa R, Abe T, Inoue KI, Takahashi A, Stoney P, Yamamoto T
iScience 2021 Oct 22;24(10):103151
iScience 2021 Oct 22;24(10):103151
The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy.
Huang T, Li X, Wang F, Lu L, Hou W, Zhu M, Miao C
Cell death & disease 2021 Mar 29;12(4):333
Cell death & disease 2021 Mar 29;12(4):333
Protein tyrosine phosphatase 1B regulates fibroblasts proliferation, motility and extracellular matrix synthesis via the MAPK/ERK signalling pathway in keloid.
Qian L, Wang Q, Wei C, Wang L, Yang Y, Deng X, Liu J, Qi F
Experimental dermatology 2021 Aug 9;
Experimental dermatology 2021 Aug 9;
Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B in Melanoma.
Du J, Dong Z, Tan L, Tan M, Zhang F, Zhang K, Pan G, Li C, Shi S, Zhang Y, Liu Y, Cui H
Frontiers in cell and developmental biology 2020;8:607757
Frontiers in cell and developmental biology 2020;8:607757
Therapeutic Role of Protein Tyrosine Phosphatase 1B in Parkinson's Disease via Antineuroinflammation and Neuroprotection In Vitro and In Vivo.
Feng CW, Chen NF, Chan TF, Chen WF
Parkinson's disease 2020;2020:8814236
Parkinson's disease 2020;2020:8814236
Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p.
Yao QP, Liu Z, Yao AH, Liu JT, Jiang J, Chen Y, Li SS, Han Y, Jiang ZL, Qi YX
Journal of cellular physiology 2020 Oct;235(10):6831-6842
Journal of cellular physiology 2020 Oct;235(10):6831-6842
CAPN1 promotes malignant behavior and erlotinib resistance mediated by phosphorylation of c-Met and PIK3R2 via degrading PTPN1 in lung adenocarcinoma.
Chen Y, Tang J, Lu T, Liu F
Thoracic cancer 2020 Jul;11(7):1848-1860
Thoracic cancer 2020 Jul;11(7):1848-1860
PTP1B promotes macrophage activation by regulating the NF-κB pathway in alcoholic liver injury.
Yang L, Sun YY, Liu YR, Yin NN, Bu FT, Yu HX, Du XS, Li J, Huang C
Toxicology letters 2020 Feb 1;319:11-21
Toxicology letters 2020 Feb 1;319:11-21
Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells.
Shi C, Yang J, Hu L, Liao B, Qiao L, Shen W, Xie F, Zhu G
Aging 2020 Aug 3;12(15):15546-15555
Aging 2020 Aug 3;12(15):15546-15555
Loss of CD36 impairs hepatic insulin signaling by enhancing the interaction of PTP1B with IR.
Yang P, Zeng H, Tan W, Luo X, Zheng E, Zhao L, Wei L, Ruan XZ, Chen Y, Chen Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5658-5672
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5658-5672
Highly Selective Protein Tyrosine Phosphatase Inhibitor, 2,2',3,3'-Tetrabromo-4,4',5,5'-tetrahydroxydiphenylmethane, Ameliorates Type 2 Diabetes Mellitus in BKS db Mice.
Li C, Luo J, Guo S, Jia X, Guo C, Li X, Xu Q, Shi D
Molecular pharmaceutics 2019 May 6;16(5):1839-1850
Molecular pharmaceutics 2019 May 6;16(5):1839-1850
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N
Cells 2019 May 31;8(6)
Cells 2019 May 31;8(6)
HDAC6 interacts with PTPN1 to enhance melanoma cells progression.
Liu J, Luan W, Zhang Y, Gu J, Shi Y, Yang Y, Feng Z, Qi F
Biochemical and biophysical research communications 2018 Jan 22;495(4):2630-2636
Biochemical and biophysical research communications 2018 Jan 22;495(4):2630-2636
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
Xiang M, Su H, Hong Z, Yang T, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 11334-1-AP(PTPN1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PTP1B antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PTP1B. This antibody recognizes human,mouse,rat antigen. The PTP1B antibody has been validated for the following applications: ELISA, WB, IHC analysis.
