51001-2-AP

antibody from Proteintech Group

Targeting: ICMT HSTE14, PCCMT, PPMT

ELISA (Data presented on provider website)

Antibody Data

Product number

51001-2-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#51001-2-AP, RRID:AB_2122574

Product name

ICMT antibody

Antibody type

Polyclonal

Description

KD/KO validated ICMT antibody (Cat. #51001-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane.

Ahearn IM, Court HR, Siddiqui F, Abankwa D, Philips MR
Life science alliance 2021 May;4(5)

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Isoprenylcysteine carboxy methyltransferase (ICMT) is associated with tumor aggressiveness and its expression is controlled by the p53 tumor suppressor.

Borini Etichetti C, Di Benedetto C, Rossi C, Baglioni MV, Bicciato S, Del Sal G, Menacho-Marquez M, Girardini J
The Journal of biological chemistry 2019 Mar 29;294(13):5060-5073

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Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.

Court H, Ahearn IM, Amoyel M, Bach EA, Philips MR
The Journal of cell biology 2017 Dec 4;216(12):4165-4182

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Downregulation of microRNA-100 enhances the ICMT-Rac1 signaling and promotes metastasis of hepatocellular carcinoma cells.

Zhou HC, Fang JH, Luo X, Zhang L, Yang J, Zhang C, Zhuang SM
Oncotarget 2014 Dec 15;5(23):12177-88

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Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.

Court H, Amoyel M, Hackman M, Lee KE, Xu R, Miller G, Bar-Sagi D, Bach EA, Bergö MO, Philips MR
The Journal of clinical investigation 2013 Nov;123(11):4681-94