NBP2-47721APCCY7

antibody from Novus Biologicals

Targeting: HLA-DQA1 CELIAC1, HLA-DQA

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-47721APCCY7

Provider

Novus Biologicals

Product name

Mouse Monoclonal HLA DQ Antibody

Antibody type

Monoclonal

Description

Protein A or G purified. Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones

Reactivity

Human, Porcine

Host

Mouse

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark. Do not freeze.