66827-1-Ig

antibody from Proteintech Group

Targeting: AIF1 AIF-1, Em:AF129756.17, IBA1, IRT-1

Provider product page for 66827-1-Ig

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Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [32]
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Product number: 66827-1-Ig - Provider product page
Provider: Proteintech Group
Product name: IBA1 antibody
Antibody type: Monoclonal
Description: IBA1 antibody (Cat. #66827-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, ELISA.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1C6A10
Vial size: 20ul, 150ul

AIF1 protein structure - 66827-1-Ig shown in red.

Submitted references Involvement of microglia-expressed MS4A6A in the onset of glioblastoma.

Lv W, Lin S, Zuo Z, Huang Z, Wang Y
The European journal of neuroscience 2024 May;59(10):2836-2849

CDDO regulates central and peripheral sensitization to attenuate post-herpetic neuralgia by targeting TRPV1/PKC-δ/p-Akt signals.

Lu CC, Lin CY, Lu YY, Tsai HP, Lin CL, Wu CH
Journal of cellular and molecular medicine 2024 Mar;28(6):e18131

N6022 attenuates cerebral ischemia/reperfusion injury-induced microglia ferroptosis by promoting Nrf2 nuclear translocation and inhibiting the GSNOR/GSTP1 axis.

Duan WL, Ma YP, Wang XJ, Ma CS, Han B, Sheng ZM, Dong H, Zhang LY, Li PA, Zhang BG, He MT
European journal of pharmacology 2024 Jun 5;972:176553

Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage.

Qi M, Liu R, Zhang F, Yao Z, Zhou ML, Jiang X, Ling S
Neuropharmacology 2024 Jun 15;251:109896

Single-Cell Transcriptomic Sequencing Reveals Tissue Architecture and Deciphers Pathological Reprogramming During Retinal Ischemia in Macaca fascicularis.

Li L, Zuo S, Liu Y, Yang L, Ge S, Ye F, Chai P, Lu L
Investigative ophthalmology & visual science 2024 Jan 2;65(1):27

Pathological features and molecular signatures of early olfactory dysfunction in 3xTg-AD model mice.

Yu H, Wang F, Jia D, Bi S, Gong J, Wu JJ, Mao Y, Chen J, Chai GS
CNS neuroscience & therapeutics 2024 Feb;30(2):e14632

Safranal acts as a neurorestorative agent in rats with cerebral ischemic stroke via upregulating SIRT1.

He F, Chen C, Wang Y, Wang S, Lyu S, Jiao J, Huang G, Yang J
Experimental and therapeutic medicine 2024 Feb;27(2):71

Neuron-targeted liposomal coenzyme Q10 attenuates neuronal ferroptosis after subarachnoid hemorrhage by activating the ferroptosis suppressor protein 1/coenzyme Q10 system.

Peng Z, Ding YN, Yang ZM, Li XJ, Zhuang Z, Lu Y, Tang QS, Hang CH, Li W
Acta biomaterialia 2024 Apr 15;179:325-339

Peroxiredoxin 2 Is a Potential Objective Indicator for Severity and the Clinical Status of Subarachnoid Hemorrhage Patients.

Peng Z, Pang C, Li XJ, Zhang HS, Zhang JT, Zhu Q, Xu HJ, Gao YY, Zhuang Z, Li W, Zhang QR, Lu Y, Hang CH
Disease markers 2023;2023:5781180

ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis.

Zhang Y, Zhang J, Zhao Y, Zhang Y, Liu L, Xu X, Wang X, Fu J
Cell death & disease 2023 Nov 6;14(11):721

ER stress induced immunopathology involving complement in CADASIL: implications for therapeutics.

Panahi M, Hase Y, Gallart-Palau X, Mitra S, Watanabe A, Low RC, Yamamoto Y, Sepulveda-Falla D, Hainsworth AH, Ihara M, Sze SK, Viitanen M, Behbahani H, Kalaria RN
Acta neuropathologica communications 2023 May 8;11(1):76

Mechanistic Insights into the Role of OPN in Mediating Brain Damage via Triggering Lysosomal Damage in Microglia/Macrophage.

Gai C, Zhao Y, Xin D, Li T, Cheng Y, Jiang Z, Song Y, Liu D, Wang Z
Cells 2023 Mar 9;12(6)

Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.

He D, Fu S, Ye B, Wang H, He Y, Li Z, Li J, Gao X, Liu D
Journal of neuroinflammation 2023 Mar 29;20(1):86

BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion.

Guo K, Shang Y, Wang Z, Li Y, Chen J, Zhu B, Zhang D, Chen J
International immunopharmacology 2023 Jun;119:110201

Hydrogen inhalation therapy regulates lactic acid metabolism following subarachnoid hemorrhage through the HIF-1α pathway.

Peng Z, Li XJ, Pang C, Zhang JT, Zhu Q, Sun JQ, Wang J, Cao BQ, Zhang YH, Lu Y, Li W, Hang CH, Zhuang Z
Biochemical and biophysical research communications 2023 Jun 30;663:192-201

Effects of magnetically targeted iron oxide@polydopamine-labeled human umbilical cord mesenchymal stem cells in cerebral infarction in mice.

Yan J, Liu T, Li Y, Zhang J, Shi B, Zhang F, Hou X, Zhang X, Cui W, Li J, Yao H, Li X, Gao Y, Jiang J
Aging 2023 Feb 28;15(4):1130-1142

CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-κB pathway.

Liu C, Yao K, Tian Q, Guo Y, Wang G, He P, Wang J, Wang J, Zhang Z, Li M
Redox biology 2023 Dec;68:102960

Hmox1 is Identified as a Ferroptosis Hub Gene and Associated with the M1 Type Microglia/Macrophage Polarization in Spinal Cord Injury: Bioinformatics and Experimental Validation.

Xuan Y, Peng K, Zhu R, Kang Y, Yin Z
Molecular neurobiology 2023 Dec;60(12):7151-7165

Fatal iatrogenic cerebral β-amyloid-related arteritis in a woman treated with lecanemab for Alzheimer's disease.

Solopova E, Romero-Fernandez W, Harmsen H, Ventura-Antunes L, Wang E, Shostak A, Maldonado J, Donahue MJ, Schultz D, Coyne TM, Charidimou A, Schrag M
Nature communications 2023 Dec 12;14(1):8220

Calycosin attenuates the inflammatory damage of microglia induced by oxygen and glucose deprivation through the HMGB1/TLR4/NF-κB signaling pathway.

Li X, Yang X, Lu H, Wang W, Cai L, Chen J, Wang Y
Acta biochimica et biophysica Sinica 2023 Aug 1;55(9):1415-1424

Analgesic effect of nobiletin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice.

Zhu C, Tian M, Liu N, Ma L, Lan X, Yang J, Du J, Ma H, Li Y, Zheng P, Yu J, Peng X
Phytotherapy research : PTR 2022 Sep;36(9):3644-3661

Sodium butyrate reduces overnutrition-induced microglial activation and hypothalamic inflammation.

Wang X, Duan C, Li Y, Lu H, Guo K, Ge X, Chen T, Shang Y, Liu H, Zhang D
International immunopharmacology 2022 Oct;111:109083

Differential perivascular microglial activation in the deep white matter in vascular dementia developed post-stroke.

Hase Y, Ameen-Ali KE, Waller R, Simpson JE, Stafford C, Mahesh A, Ryan L, Pickering L, Bodman C, Hase M, Boche D, Horsburgh K, Wharton SB, Kalaria RN
Brain pathology (Zurich, Switzerland) 2022 Nov;32(6):e13101

An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation.

Ferretti G, Romano A, Sirabella R, Serafini S, Maier TJ, Matrone C
Cell & bioscience 2022 Nov 8;12(1):182

Repair of Spinal Cord Injury by Inhibition of PLK4 Expression Through Local Delivery of siRNA-Loaded Nanoparticles.

Gu Y, Zhang R, Jiang B, Xu X, Guan JJ, Jiang XJ, Zhou Y, Zhou YL, Chen X
Journal of molecular neuroscience : MN 2022 Mar;72(3):544-554

Malignant Melanoma-Derived Exosomes Induce Endothelial Damage and Glial Activation on a Human BBB Chip Model.

Wang P, Wu Y, Chen W, Zhang M, Qin J
Biosensors 2022 Jan 31;12(2)

Senkyunolide I Protects against Sepsis-Associated Encephalopathy by Attenuating Sleep Deprivation in a Murine Model of Cecal Ligation and Puncture.

Xie J, Zhao ZZ, Li P, Zhu CL, Guo Y, Wang J, Deng XM, Wang JF
Oxidative medicine and cellular longevity 2021;2021:6647258

Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.

Huo S, Ren J, Ma Y, Ozathaley A, Yuan W, Ni H, Li D, Liu Z
Journal of neuroinflammation 2021 Nov 26;18(1):275

CCP1, a Tubulin Deglutamylase, Increases Survival of Rodent Spinal Cord Neurons following Glutamate-Induced Excitotoxicity.

Ramadan YH, Gu A, Ross N, McEwan SA, Barr MM, Firestein BL, O'Hagan R
eNeuro 2021 Mar-Apr;8(2)

Proto-oncogene tyrosine-protein kinase SRC (Src) inhibition in microglia relieves neuroinflammation in neuropathic pain mouse models.

Cai Y, Xu J, Cheng Q
Bioengineered 2021 Dec;12(2):11390-11398

Plasminogen Activator Urokinase Receptor Implies Immunosuppressive Features and Acts as an Unfavorable Prognostic Biomarker in Glioma.

Zeng F, Li G, Liu X, Zhang K, Huang H, Jiang T, Zhang Y
The oncologist 2021 Aug;26(8):e1460-e1469

Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.

Xu C, Diao YF, Wang J, Liang J, Xu HH, Zhao ML, Zheng B, Luan Z, Wang JJ, Yang XP, Wei MG, Duan JH, Wang KQ, Chen C, Chen F, Ming D, Zhang S, Sun HT, Li XH
Stem cells and development 2020 Feb 15;29(4):222-234

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