Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations [0]
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- Product number
- AF662 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse OSMR beta Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects mouse OSM R beta in direct ELISAs and Western blots.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
O70458
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis.
Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo.
Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury.
Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.
Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.
Lack of oncostatin M receptor β leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype.
A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor.
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
Martínez-Fábregas J, Prescott A, van Kasteren S, Pedrioli DL, McLean I, Moles A, Reinheckel T, Poli V, Watts C
Nature communications 2018 Dec 17;9(1):5343
Nature communications 2018 Dec 17;9(1):5343
Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo.
Elks CM, Zhao P, Grant RW, Hang H, Bailey JL, Burk DH, McNulty MA, Mynatt RL, Stephens JM
The Journal of biological chemistry 2016 Aug 12;291(33):17066-76
The Journal of biological chemistry 2016 Aug 12;291(33):17066-76
Oncostatin m, an inflammatory cytokine produced by macrophages, supports intramembranous bone healing in a mouse model of tibia injury.
Guihard P, Boutet MA, Brounais-Le Royer B, Gamblin AL, Amiaud J, Renaud A, Berreur M, Rédini F, Heymann D, Layrolle P, Blanchard F
The American journal of pathology 2015 Mar;185(3):765-75
The American journal of pathology 2015 Mar;185(3):765-75
Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice.
Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y
The Journal of biological chemistry 2014 May 16;289(20):13821-37
The Journal of biological chemistry 2014 May 16;289(20):13821-37
Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts.
Le Goff B, Singbrant S, Tonkin BA, Martin TJ, Romas E, Sims NA, Walsh NC
Cytokine 2014 Aug;68(2):101-9
Cytokine 2014 Aug;68(2):101-9
Lack of oncostatin M receptor β leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype.
Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y
The Journal of biological chemistry 2013 Jul 26;288(30):21861-75
The Journal of biological chemistry 2013 Jul 26;288(30):21861-75
A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor.
Chollangi S, Mather T, Rodgers KK, Ash JD
The Journal of biological chemistry 2012 Sep 21;287(39):32848-59
The Journal of biological chemistry 2012 Sep 21;287(39):32848-59
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis.
Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C
The Journal of biological chemistry 2011 Sep 30;286(39):34271-85
The Journal of biological chemistry 2011 Sep 30;286(39):34271-85
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