12-1303-42

antibody from Invitrogen Antibodies
Targeting: OSMR OSMRB, OSMRbeta
Provider product page for 12-1303-42

Antibody data

Product number
12-1303-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
OSMR Monoclonal Antibody (AN-V2), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This monoclonal AN-V2 antibody reacts with the human oncostatin M (OSM) receptor. OSM, which belongs to the interleukin-6 cytokine family, is produced by T cells, activated monocytes, and dendritic cells. In humans, OSM can bind two unique receptor complexes. The type I OSM receptor is composed of the LIFR associated with gp130, and recognizes both LIF and OSM. The type II OSM receptor, which consists of gp130 and the OSMR subunit, specifically binds the cytokine, leading to activation of the JAK/STAT signaling pathway. Reports have also indicated a soluble form of the OSM receptor, which this antibody also recognizes. The OSM receptor is expressed in the bone marrow, endothelium, liver, lung, and numerous tumor cell lines.
Conjugate
Yellow dye
Antibody clone number
AN-V2
Concentration
5 µL/Test
OSMR protein structure - 12-1303-42 shown in red.