Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 12-1303-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- OSMR Monoclonal Antibody (AN-V2), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This monoclonal AN-V2 antibody reacts with the human oncostatin M (OSM) receptor. OSM, which belongs to the interleukin-6 cytokine family, is produced by T cells, activated monocytes, and dendritic cells. In humans, OSM can bind two unique receptor complexes. The type I OSM receptor is composed of the LIFR associated with gp130, and recognizes both LIF and OSM. The type II OSM receptor, which consists of gp130 and the OSMR subunit, specifically binds the cytokine, leading to activation of the JAK/STAT signaling pathway. Reports have also indicated a soluble form of the OSM receptor, which this antibody also recognizes. The OSM receptor is expressed in the bone marrow, endothelium, liver, lung, and numerous tumor cell lines.
- Conjugate
- Yellow dye
- Antibody clone number
- AN-V2
- Concentration
- 5 µL/Test
Submitted references Human basophils are a source of - and are differentially activated by - IL-31.
Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor.
Raap U, Gehring M, Kleiner S, RĂ¼drich U, Eiz-Vesper B, Haas H, Kapp A, Gibbs BF
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2017 Apr;47(4):499-508
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2017 Apr;47(4):499-508
Molecular and functional characterization of a soluble form of oncostatin M/interleukin-31 shared receptor.
Diveu C, Venereau E, Froger J, Ravon E, Grimaud L, Rousseau F, Chevalier S, Gascan H
The Journal of biological chemistry 2006 Dec 1;281(48):36673-82
The Journal of biological chemistry 2006 Dec 1;281(48):36673-82
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Staining of the Jurkat (left) and A375 (right) cell lines with Mouse IgG1 K Isotype Control PE (Product # 12-4714-81) (blue histogram) or Anti-Human Oncostatin M Receptor PE (purple histogram). Total viable cells were used for analysis.
- Conjugate
- Yellow dye