12-1303-42

antibody from Invitrogen Antibodies
Targeting: OSMR OSMRB, OSMRbeta
Provider product page for 12-1303-42

Antibody data

Product number
12-1303-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
OSMR Monoclonal Antibody (AN-V2), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This monoclonal AN-V2 antibody reacts with the human oncostatin M (OSM) receptor. OSM, which belongs to the interleukin-6 cytokine family, is produced by T cells, activated monocytes, and dendritic cells. In humans, OSM can bind two unique receptor complexes. The type I OSM receptor is composed of the LIFR associated with gp130, and recognizes both LIF and OSM. The type II OSM receptor, which consists of gp130 and the OSMR subunit, specifically binds the cytokine, leading to activation of the JAK/STAT signaling pathway. Reports have also indicated a soluble form of the OSM receptor, which this antibody also recognizes. The OSM receptor is expressed in the bone marrow, endothelium, liver, lung, and numerous tumor cell lines. The AN-V2 monoclonal antibody recognizes the type II (beta) OSM receptor. Applications Reported: This AN-V2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This AN-V2 antibody has been pre-titrated and tested by flow cytometric analysis of the A375 cell line. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 µm post-manufacturing filtered.
Reactivity
Human
Host
Mouse
Conjugate
Yellow dye
Isotype
IgG
Antibody clone number
AN-V2
Vial size
100 Tests
Concentration
5 µL/Test
Storage
4° C, store in dark, DO NOT FREEZE!
OSMR protein structure - 12-1303-42 shown in red.