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- References [16]
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- Product number
- 15448-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- HOXC8 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HOXC8 antibody (Cat. #15448-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Establishment of a xenograft model of endometriosis-associated fibrosis using human immortalized endometrial stromal cells overexpressing HOXC8.
Skin regional specification and higher-order HoxC regulation.
LINC01013 reverses bisphosphonate-impaired osteogenic differentiation of JBMMSCs by regulating intracellular translocation of ILF3.
CAF-derived exosomal miR-196b-5p after androgen deprivation therapy promotes epithelial-mesenchymal transition in prostate cancer cells through HOXC8/NF-κB signaling pathway.
HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression.
Methionine restriction alleviates kidney fibrosis through epigenetic repression of the TGF-β-Smad3-Hoxc8/P-TEFb axis.
N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.
Comprehensive analysis of HOXC8 associated with tumor microenvironment characteristics in colorectal cancer.
DLX2 promotes osteosarcoma epithelial-mesenchymal transition and doxorubicin resistance by enhancing HOXC8-CDH2 axis.
HOXC8/TGF-β1 positive feedback loop promotes liver fibrosis and hepatic stellate cell activation via activating Smad2/Smad3 signaling.
Divergent transcriptional regulation of astrocyte reactivity across disorders.
miR-301a inhibits adipogenic differentiation of adipose-derived stromal vascular fractions by targeting HOXC8 in sheep.
Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation.
Homeobox C8 is a transcriptional repressor of E-cadherin gene expression in non-small cell lung cancer.
Upregulation of MGP by HOXC8 promotes the proliferation, migration, and EMT processes of triple-negative breast cancer.
HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFβ1 in non-small cell lung cancer.
Takasaki-Kawasaki H, Sato S, Tamehisa T, Yoneda T, Shiroshita A, Fujimura T, Tamura I, Maekawa R, Sugino N
Scientific reports 2026 Feb 27;16(1)
Scientific reports 2026 Feb 27;16(1)
Skin regional specification and higher-order HoxC regulation.
Li SH, Liang YC, Jiang TX, Jea WC, Chih-Kuan Chen, Lu J, Núñez-León D, Yu Z, Lai YC, Widelitz RB, Andersson L, Wu P, Chuong CM
Science advances 2025 Mar 21;11(12):eado2223
Science advances 2025 Mar 21;11(12):eado2223
LINC01013 reverses bisphosphonate-impaired osteogenic differentiation of JBMMSCs by regulating intracellular translocation of ILF3.
Song J, Wang W, Feng X, Yang H, Shan Z, Fan Z
Stem cell research & therapy 2025 Jun 23;16(1):319
Stem cell research & therapy 2025 Jun 23;16(1):319
CAF-derived exosomal miR-196b-5p after androgen deprivation therapy promotes epithelial-mesenchymal transition in prostate cancer cells through HOXC8/NF-κB signaling pathway.
Song X, Li T, Zhou W, Feng C, Zhou Z, Chen Y, Li D, Chen L, Zhao J, Zhang Y, Han B
Biology direct 2025 Jul 4;20(1):80
Biology direct 2025 Jul 4;20(1):80
HOXC8 impacts lung tumorigenesis by preventing pyroptotic cell death through the suppression of caspase-1 expression.
Padia R, Sun L, Liao YF, Calbay O, Chi C, Akter M, Wu L, Fu Z, Zhang DD, Huang S
Cell death & disease 2025 Jul 23;16(1):552
Cell death & disease 2025 Jul 23;16(1):552
Methionine restriction alleviates kidney fibrosis through epigenetic repression of the TGF-β-Smad3-Hoxc8/P-TEFb axis.
Liu Y, Liu Z, Liu L, Su Y, Chen J, Qing B, Tang C, Zhang Z, Ji R, Cao X, Wang T, Jia J, Chen Y, Zhang L
Nature communications 2025 Dec 31;17(1):1301
Nature communications 2025 Dec 31;17(1):1301
N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.
Li J, Xu X, Xu K, Zhou X, Wu K, Yao Y, Liu Z, Chen C, Wang L, Sun Z, Jiao D, Han X
Journal of experimental & clinical cancer research : CR 2024 Apr 20;43(1):119
Journal of experimental & clinical cancer research : CR 2024 Apr 20;43(1):119
Comprehensive analysis of HOXC8 associated with tumor microenvironment characteristics in colorectal cancer.
Wu S, Zhu D, Feng H, Li Y, Zhou J, Li Y, Hou T
Heliyon 2023 Nov;9(11):e21346
Heliyon 2023 Nov;9(11):e21346
DLX2 promotes osteosarcoma epithelial-mesenchymal transition and doxorubicin resistance by enhancing HOXC8-CDH2 axis.
Zhang B, Du X, Fan Y, Qu G, Pang LK, Zhao R, Yao W
iScience 2023 Nov 17;26(11):108272
iScience 2023 Nov 17;26(11):108272
HOXC8/TGF-β1 positive feedback loop promotes liver fibrosis and hepatic stellate cell activation via activating Smad2/Smad3 signaling.
Zhang N, Guo F, Song Y
Biochemical and biophysical research communications 2023 Jun 25;662:39-46
Biochemical and biophysical research communications 2023 Jun 25;662:39-46
Divergent transcriptional regulation of astrocyte reactivity across disorders.
Burda JE, O'Shea TM, Ao Y, Suresh KB, Wang S, Bernstein AM, Chandra A, Deverasetty S, Kawaguchi R, Kim JH, McCallum S, Rogers A, Wahane S, Sofroniew MV
Nature 2022 Jun;606(7914):557-564
Nature 2022 Jun;606(7914):557-564
miR-301a inhibits adipogenic differentiation of adipose-derived stromal vascular fractions by targeting HOXC8 in sheep.
Zhao B, Pan Y, Qiao L, Liu J, Yang K, Liang Y, Liu W
Animal science journal = Nihon chikusan Gakkaiho 2021;92(1):e13661
Animal science journal = Nihon chikusan Gakkaiho 2021;92(1):e13661
Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation.
Shiimori M, Ichida Y, Nukiwa R, Sakuma T, Abe H, Kajitani R, Fujino Y, Kikuchi A, Kawamura T, Kodama T, Toyooka S, Shirahige K, Schotta G, Kuba K, Itoh T, Imai Y
iScience 2021 Jun 25;24(6):102660
iScience 2021 Jun 25;24(6):102660
Homeobox C8 is a transcriptional repressor of E-cadherin gene expression in non-small cell lung cancer.
Zhang J, Yang M, Li D, Zhu S, Zou J, Xu S, Wang Y, Shi J, Li Y
The international journal of biochemistry & cell biology 2019 Sep;114:105557
The international journal of biochemistry & cell biology 2019 Sep;114:105557
Upregulation of MGP by HOXC8 promotes the proliferation, migration, and EMT processes of triple-negative breast cancer.
Gong C, Zou J, Zhang M, Zhang J, Xu S, Zhu S, Yang M, Li D, Wang Y, Shi J, Li Y
Molecular carcinogenesis 2019 Oct;58(10):1863-1875
Molecular carcinogenesis 2019 Oct;58(10):1863-1875
HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFβ1 in non-small cell lung cancer.
Liu H, Zhang M, Xu S, Zhang J, Zou J, Yang C, Zhang Y, Gong C, Kai Y, Li Y
Oncogenesis 2018 Jan 17;7(2):1
Oncogenesis 2018 Jan 17;7(2):1
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Supportive validation
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The HOXC8 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human HOXC8. This antibody recognizes human,mouse,rat antigen. The HOXC8 antibody has been validated for the following applications: ELISA, WB analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with 15448-1-AP( HOXC8 Antibody) at dilution of 1:300
- Other comments
- WB
