Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 329613 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#329613, RRID:AB_2565428
- Product name
- Purified anti-human CD273 (B7-DC, PD-L2) (MaxPar® Ready)
- Antibody type
- Monoclonal
- Antigen
- Human PD-L2 cDNA
- Description
- CD273, known as B7-DC, is also called programmed death ligand 2 (PDL2). This ligand is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily and is expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. CD273 has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 24F.10C12
- Vial size
- 100 µg
- Concentration
- 1.0 mg/ml
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human monocyte-derived dendritic cells stained wtih 154Sm-anti CD45 (HI30) and 172Yb-anti-CD273/PD0L2 (24F.10C12). CD3-CD11c+ ciable cells are displayed in the analysis.
- Conjugate
- Unconjugated