Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 329606 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#329606, RRID:AB_1089019
- Product name
- PE anti-human CD273 (B7-DC, PD-L2)
- Antibody type
- Monoclonal
- Antigen
- Human PD-L2 cDNA
- Description
- CD273, known as B7-DC, is also called programmed death ligand 2 (PDL2). This ligand is a 25 kD type I transmembrane protein and a member of B7 family within the immunoglobulin receptor superfamily and is expressed on a subset of dendritic cells, liver and a small subset of macrophages as well as a few transformed cell lines. CD273 has been reported to be stimulatory on dendritic cells when cross-linked and to inhibit T cell activation upon engaging the PD-1 receptor. CD273 has also been reported to bind to an alternative receptor and to mediate T cell activation through such non-PD1 mediated interactions.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 100 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production.
Brown JA, Dorfman DM, Ma FR, Sullivan EL, Munoz O, Wood CR, Greenfield EA, Freeman GJ
Journal of immunology (Baltimore, Md. : 1950) 2003 Feb 1;170(3):1257-66
Journal of immunology (Baltimore, Md. : 1950) 2003 Feb 1;170(3):1257-66
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Monocyte-derived dendritic cells stained with 24F.10C12 PE
- Conjugate
- Yellow dye