AF2826

antibody from R&D Systems

Targeting: TIMD4 TIM4

Western blot (Data presented on provider website)

Antibody Data

Product number

AF2826

Provider

R&D Systems

Product name

Mouse TIM-4 Antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified. Detects mouse TIM-4 in direct ELISAs and Western blots. In direct ELISAs, less than 2% cross-reactivity with recombinant human (rh) TIM-1, recombinant mouse (rm) TIM-2, rmTIM-3, rhTIM-4, rmTIM-5, and rmTIM-6 is observed.

Reactivity

Mouse

Host

Goat

Conjugate

Unconjugated

Antigen sequence

Q6U7R4


Isotype

IgG

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Mouse macrophages show different requirements for phosphatidylserine receptor Tim4 in efferocytosis.

Yanagihashi Y, Segawa K, Maeda R, Nabeshima YI, Nagata S
Proceedings of the National Academy of Sciences of the United States of America 2017 Aug 15;114(33):8800-8805

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T cell Ig domain and mucin domain 1 engagement on invariant NKT cells in the presence of TCR stimulation enhances IL-4 production but inhibits IFN-gamma production.

Kim HS, Kim HS, Lee CW, Chung DH
Journal of immunology (Baltimore, Md. : 1950) 2010 Apr 15;184(8):4095-106

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TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells.

Nakae S, Iikura M, Suto H, Akiba H, Umetsu DT, Dekruyff RH, Saito H, Galli SJ
Blood 2007 Oct 1;110(7):2565-8