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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [13]
- Comments [0]
- Validations [0]
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- Product number
- HPA036825 - Provider product page
- Provider
- Atlas Antibodies
- Proper citation
- Atlas Antibodies Cat#HPA036825, RRID:AB_10672231
- Product name
- Anti-NGLY1
- Antibody type
- Polyclonal
- Description
- Polyclonal Antibody against Human NGLY1, Gene description: N-glycanase 1, Alternative Gene Names: FLJ11005, PNG1, Validated applications: IHC, Uniprot ID: Q96IV0, Storage: Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- 0.1 mg/ml
- Storage
- Store at +4°C for short term storage. Long time storage is recommended at -20°C.
- Handling
- The antibody solution should be gently mixed before use.
Submitted references Systemic gene therapy corrects the neurological phenotype in a mouse model of NGLY1 deficiency
N‐glycoproteomics reveals distinct glycosylation alterations in NGLY1‐deficient patient‐derived dermal fibroblasts
AAV9-NGLY1 gene replacement therapy improves phenotypic and biomarker endpoints in a rat model of NGLY1 Deficiency
GlcNAc-Asn is a biomarker for NGLY1 deficiency
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
NGLY1 Deficiency Zebrafish Model Manifests Abnormalities of the Nervous and Musculoskeletal Systems
JF1/B6F1 Ngly1(-/-) mouse as an isogenic animal model of NGLY1 deficiency.
Reversibility of motor dysfunction in the rat model of NGLY1 deficiency.
Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation
Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines
Ngly1 -/- rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems.
Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1
A congenital disorder of deglycosylation: Biochemical characterization ofN-glycanase 1 deficiency in patient fibroblasts
Du A, Yang K, Zhou X, Ren L, Liu N, Zhou C, Liang J, Yan N, Gao G, Wang D
JCI Insight 2024;9(19)
JCI Insight 2024;9(19)
N‐glycoproteomics reveals distinct glycosylation alterations in NGLY1‐deficient patient‐derived dermal fibroblasts
Budhraja R, Saraswat M, De Graef D, Ranatunga W, Ramarajan M, Mousa J, Kozicz T, Pandey A, Morava E
Journal of Inherited Metabolic Disease 2022;46(1):76-91
Journal of Inherited Metabolic Disease 2022;46(1):76-91
AAV9-NGLY1 gene replacement therapy improves phenotypic and biomarker endpoints in a rat model of NGLY1 Deficiency
Zhu L, Tan B, Dwight S, Beahm B, Wilsey M, Crawford B, Schweighardt B, Cook J, Wechsler T, Mueller W
Molecular Therapy - Methods & Clinical Development 2022;27
Molecular Therapy - Methods & Clinical Development 2022;27
GlcNAc-Asn is a biomarker for NGLY1 deficiency
Mueller W, Zhu L, Tan B, Dwight S, Beahm B, Wilsey M, Wechsler T, Mak J, Cowan T, Pritchett J, Taylor E, Crawford B
The Journal of Biochemistry 2022;171(2):177-186
The Journal of Biochemistry 2022;171(2):177-186
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
Forcina G, Pope L, Murray M, Dong W, Abu-Remaileh M, Bertozzi C, Dixon S
Proceedings of the National Academy of Sciences 2022;119(11)
Proceedings of the National Academy of Sciences 2022;119(11)
NGLY1 Deficiency Zebrafish Model Manifests Abnormalities of the Nervous and Musculoskeletal Systems
Mesika A, Nadav G, Shochat C, Kalfon L, Jackson K, Khalaileh A, Karasik D, Falik-Zaccai T
Frontiers in Cell and Developmental Biology 2022;10
Frontiers in Cell and Developmental Biology 2022;10
JF1/B6F1 Ngly1(-/-) mouse as an isogenic animal model of NGLY1 deficiency.
Asahina M, Fujinawa R, Fujihira H, Masahara-Negishi Y, Andou T, Tozawa R, Suzuki T
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2021;97(2):89-102
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2021;97(2):89-102
Reversibility of motor dysfunction in the rat model of NGLY1 deficiency.
Asahina M, Fujinawa R, Hirayama H, Tozawa R, Kajii Y, Suzuki T
Molecular brain 2021 Jun 13;14(1):91
Molecular brain 2021 Jun 13;14(1):91
Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation
Galeone A, Adams J, Matsuda S, Presa M, Pandey A, Han S, Tachida Y, Hirayama H, Vaccari T, Suzuki T, Lutz C, Affolter M, Zuberi A, Jafar-Nejad H
eLife 2020;9
eLife 2020;9
Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines
Mueller W, Jakob P, Sun H, Clauder-Münster S, Ghidelli-Disse S, Ordonez D, Boesche M, Bantscheff M, Collier P, Haase B, Benes V, Paulsen M, Sehr P, Lewis J, Drewes G, Steinmetz L
G3 Genes|Genomes|Genetics 2020;10(5):1585-1597
G3 Genes|Genomes|Genetics 2020;10(5):1585-1597
Ngly1 -/- rats develop neurodegenerative phenotypes and pathological abnormalities in their peripheral and central nervous systems.
Asahina M, Fujinawa R, Nakamura S, Yokoyama K, Tozawa R, Suzuki T
Human molecular genetics 2020 Jun 27;29(10):1635-1647
Human molecular genetics 2020 Jun 27;29(10):1635-1647
Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1
Galeone A, Han S, Huang C, Hosomi A, Suzuki T, Jafar-Nejad H
eLife 2017;6
eLife 2017;6
A congenital disorder of deglycosylation: Biochemical characterization ofN-glycanase 1 deficiency in patient fibroblasts
He P, Grotzke J, Ng B, Gunel M, Jafar-Nejad H, Cresswell P, Enns G, Freeze H
Glycobiology 2015;25(8):836-844
Glycobiology 2015;25(8):836-844
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