BS5774
antibody from Bioworld Technology, Inc
Targeting: KIF4A
FLJ12530, FLJ12655, FLJ14204, FLJ20631, HSA271784, KIF4, KIF4-G1, MRX100
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS5774 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- KIF4A polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 1187-1232 of Human KIF4A.
- Description
- The kinesin superfamily proteins (KIFs) are microtubule-dependent molecular motors that transport membranous organelles and protein complexes in a microtubule- and ATP-dependent manner. Cells use KIFs to tightly control the direction, destination and speed of transportation of a variety of important functional molecules, including mRNA. KIF4A functions as an essential chromosome-associated molecular motor involved in faithful chromosome segregation. It is found in the nucleoplasm during interphase and on condensed chromosome arms during mitosis. KIF4A accumulates in the mid-zone duing late anaphase and on the cytokinetic ring during cytokinesis. KIF4 binds to and translocates PRC1, a spindle mid-zone-associated cyclin-dependent kinase that plays a role in cytokinesis. KIF4A may also interact with the condensin I and II complexes. Loss of KIF4A leads to chromosome hypercondensation, suggesting that it is necessary for retaining normal chromosome architecture.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of KIF4A pAb at 1:500 dilutionLane1:MCF-7 cell lysateLane2:sp2/0 cell lysate