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- Antigen structure
- References [107]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 10501-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10501-1-AP, RRID:AB_2172597
- Product name
- PSAT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PSAT1 antibody (Cat. #10501-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PSAT1 inhibits mTORC1 activation by preventing Rag heterodimer formation in lung adenocarcinoma.
Txnrd2 loss in skeletal muscle causes muscle atrophy and drives leanness and obesity resistance.
PGK1/PHGDH axis drives radioresistance in glioblastoma stem cells.
Bioinformatics-based discovery of the involvement of PSAT1 in mediating the anti-lung adenocarcinoma activity of triptolide.
Targeting serine synthesis pathway to reverse paclitaxel resistance in NSCLC with combination of paclitaxel and anlotinib.
Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas.
ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC.
PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability.
Regulation of PSAT1 and PHGDH by m6A in endocrine-resistant breast cancer cells.
Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway.
Ti(3)C(2)Tx MXene Potentiates PSAT1-Mediated Osteogenesis Through miR-665/GSK-3β/β-Catenin Axis to Counteract Inflammation-Induced Bone Loss.
Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer.
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation.
SOX12 promotes serine synthesis and tumor progression in endometrial cancer.
Clinical, neuropathological, and biochemical characterization of ALS in a large CHCHD10 R15L family.
Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells.
PSAT1 knockdown mediated VDAC1 oligomerization promotes ferroptosis and suppresses cell proliferation in esophageal squamous cell carcinoma.
Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures.
Oxidative stress reactivates androgen receptor signaling via USP36 to drive castration resistance in prostate cancer.
m(6)A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability.
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer.
An in vivo screen identifies NAT10 as a master regulator of brain metastasis.
ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis.
Kinesin-related genes stratified the prognosis and immune responses of clear cell renal cell carcinoma.
The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms.
Bioinformatics analysis of PSAT1 loss identifies downstream pathways regulated in EGFR mutant NSCLC and a selective gene signature for predicting the risk of relapse.
Ailanthone targets the KMT2A-MEN1 complex to suppress lung metastasis of osteosarcoma.
Bioinformatics analysis of ferroptosis-related hub genes and immunoinfiltration in myocardial ischemia/reperfusion following heart transplantation.
Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3-dependent PDGFB signaling.
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury.
Tanshinone IIA alleviates pulmonary fibrosis by modulating glutamine metabolic reprogramming based on [U-(13)C(5)]-glutamine metabolic flux analysis.
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
N6-methyladenosine modification of LATS2 promotes hepatoblastoma progression by inhibiting ferroptosis through the YAP1/ATF4/PSAT1 axis.
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype.
Prognostic Signature in Osteosarcoma Based on Amino Acid Metabolism-Associated Genes.
Metabolic adaptation in epithelial ovarian cancer metastasis.
Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.
PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress.
l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.
CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer.
PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.
Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis.
Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1 and blocking the binding of HMGB1 to the viral genome.
BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer.
Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression.
A novel and ubiquitous miRNA-involved regulatory module ensures precise phosphorylation of RNA polymerase II and proper transcription.
PSAT1 enhances the efficacy of the prognosis estimation nomogram model in stage-based clear cell renal cell carcinoma.
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma.
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth.
Comparative multi-omic analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency.
MicroRNA regulation of the serine synthesis pathway in endocrine-resistant breast cancer cells.
Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma.
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer.
Comprehensive Analysis of Prognosis and Immune Landscapes Based on Lipid-Metabolism- and Ferroptosis-Associated Signature in Uterine Corpus Endometrial Carcinoma.
Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes.
Lycorine eliminates B-cell acute lymphoblastic leukemia cells by targeting PSAT1 through the serine/glycine metabolic pathway.
FGFR3 Alterations in Bladder Cancer Stimulate Serine Synthesis to Induce Immune-Inert Macrophages That Suppress T-cell Recruitment and Activation.
Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.
Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway.
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
Metabolic and Nonmetabolic Functions of PSAT1 Coordinate Signaling Cascades to Confer EGFR Inhibitor Resistance and Drive Progression in Lung Adenocarcinoma.
Single-cell analysis of human testis aging and correlation with elevated body mass index.
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1.
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.
PERK is a critical metabolic hub for immunosuppressive function in macrophages.
Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic.
Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1.
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
Monosaccharide-mediated rational synthesis of a universal plasmonic platform with broad spectral fluorescence enhancement for high-sensitivity cancer biomarker analysis.
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation.
Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression.
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.
Serine synthesis influences tamoxifen response in ER+ human breast carcinoma.
Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16.
Proteomic profile of human dental follicle stem cells and apical papilla stem cells.
LncRNA MEG8 promotes NSCLC progression by modulating the miR-15a-5p-miR-15b-5p/PSAT1 axis.
Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells.
Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism.
PSAT1 Regulated Oxidation-Reduction Balance Affects the Growth and Prognosis of Epithelial Ovarian Cancer.
TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis.
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer.
The auxiliary diagnostic value of prostate-specific antigen and α-methylacyl-CoA racemase in prostate cancer.
SOX2 has dual functions as a regulator in the progression of neuroendocrine prostate cancer.
The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.
The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.
A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice.
Serine Is an Essential Metabolite for Effector T Cell Expansion.
A simple method based on Sanger sequencing and MS Word wildcard searching to identify Cas9-induced frameshift mutations.
Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro.
Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma.
Stem cell function and stress response are controlled by protein synthesis.
MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific biomarkers.
Liu Y, Cheng Z, Zhang J, Zhang Y, Zhao T, Sun L, Wen G, Han T, Wang J
Autophagy 2026 Mar;22(3):468-483
Autophagy 2026 Mar;22(3):468-483
Txnrd2 loss in skeletal muscle causes muscle atrophy and drives leanness and obesity resistance.
Kiermayer C, Erdelen R, Schriever SC, Böhm R, Prehn C, Artati A, Kleinert M, Miller M, Dyar KA, Schmid RM, Pfluger PT, Adamski J, Brielmeier M
Redox biology 2026 Jun;93:104165
Redox biology 2026 Jun;93:104165
PGK1/PHGDH axis drives radioresistance in glioblastoma stem cells.
Cheng Z, Ding F, Yin J, Wang Y, Gao Y, Ge X, Zhang J, Wang X, Zhao M, Zhao N, Shu C, Wang X, Qian X, Qian C, Ji J, You Y, Shi Z
Cancer letters 2026 Jul 10;650:218517
Cancer letters 2026 Jul 10;650:218517
Bioinformatics-based discovery of the involvement of PSAT1 in mediating the anti-lung adenocarcinoma activity of triptolide.
Cao Z, Zhang L, Zhang W, Wan R, Peng X, Xie J, Bai R, Jin J, Shi C, Yan L, Guo X, Shen Y, Lu C
Animal models and experimental medicine 2026 Jan;9(1):115-127
Animal models and experimental medicine 2026 Jan;9(1):115-127
Targeting serine synthesis pathway to reverse paclitaxel resistance in NSCLC with combination of paclitaxel and anlotinib.
Yu M, Hong Y, Pan Q, Zheng P, He Y, Zhu W, Xu S, Lv Q
Journal of experimental & clinical cancer research : CR 2026 Jan 5;45(1):30
Journal of experimental & clinical cancer research : CR 2026 Jan 5;45(1):30
Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas.
Aussel A, Nemazanyy I, Vandenberghe A, Meola P, Dorat N, Paul R, Habbouche L, Exposito L, Nottet N, Petrilli V, Chiche E, Mounier N, Marchetti S, Chaveroux C, Ricci JE, Chiche J
Nature communications 2026 Feb 27;17(1)
Nature communications 2026 Feb 27;17(1)
ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC.
Deng L, Yang X, Zhang J, Zhou X, Ma R, Wu Z, Chen H
Cell death & disease 2026 Feb 17;17(1):227
Cell death & disease 2026 Feb 17;17(1):227
PSAT1 Promotes NSCLC Progression via the De Novo Serine Synthesis Pathway and Represents a Therapeutic Vulnerability.
Zhou X, Zhao M, Cao Y, Zhou X, Wang K
Cancer medicine 2026 Apr;15(4):e71780
Cancer medicine 2026 Apr;15(4):e71780
Regulation of PSAT1 and PHGDH by m6A in endocrine-resistant breast cancer cells.
Piell KM, Vallarta A, Wilt AE, Avila-Valdes BL, Sumlut MH, Goli N, Petri BJ, He L, Zhang X, Clem BF, Klinge CM
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 15;:168266
Biochimica et biophysica acta. Molecular basis of disease 2026 Apr 15;:168266
Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway.
Feng L, Xiao G, Chen Y, Ye T, Fan L, Xie Y, Mei T, Wang L, Ge J, Ye C, Chen J
International journal of biological sciences 2025;21(9):4153-4171
International journal of biological sciences 2025;21(9):4153-4171
Ti(3)C(2)Tx MXene Potentiates PSAT1-Mediated Osteogenesis Through miR-665/GSK-3β/β-Catenin Axis to Counteract Inflammation-Induced Bone Loss.
Zhang J, Wang X, Xiao J, Hong H, Chen J, Wu C, Xu G, Cui Z
International journal of nanomedicine 2025;20:11151-11168
International journal of nanomedicine 2025;20:11151-11168
Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer.
Jansen C, McAdams J, Kim C, De La Cruz P, Salaverria A, DaSilva NA, Grive K, James NE
Frontiers in pharmacology 2025;16:1547164
Frontiers in pharmacology 2025;16:1547164
PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation.
Zheng P, Hu Z, Shen Y, Gu L, Ouyang Y, Duan Y, Ji G, Dong B, Lin Y, Wen T, Tian Q, Hou Y, Zhou Q, Sun X, Chen X, Wang KL, Luo S, Wu S, Sun Y, Li M, Xiao L, Wu Q, Meng Y, Liu G, Wang Z, Bai X, Duan S, Ding Y, Bi Y, Wang Y, Li G, Liu X, Lu Z, Wu X, Tang Z, Xu D
Nature chemical biology 2025 Sep;21(9):1420-1432
Nature chemical biology 2025 Sep;21(9):1420-1432
SOX12 promotes serine synthesis and tumor progression in endometrial cancer.
Zhang ZH, Hui Y, Wan Q, Hu XY, Wang H, Liu CC, Wan FZ, Huang CY, Yi FX, Zeng SH, Li S, Ye H
Cellular signalling 2025 Sep;133:111870
Cellular signalling 2025 Sep;133:111870
Clinical, neuropathological, and biochemical characterization of ALS in a large CHCHD10 R15L family.
Kwan JY, Lantz CI, Korobeynikov VA, Snyder A, Huang X, Haselhuhn T, Dore KN, Madruga A, Danielian LE, Schindler AB, Chia R, Rasheed M, Crook J, Szabo M, Portley M, Sherer CM, King MC, Huang TH, Kosa P, Bielekova B, Ward ME, Grunseich C, Shneider NA, Traynor BJ, Narendra DP
medRxiv : the preprint server for health sciences 2025 Sep 26;
medRxiv : the preprint server for health sciences 2025 Sep 26;
Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells.
Kanaan MN, Karam CY, Kennedy LS, Pileggi CA, Hamilton L, Cuperlovic-Culf M, Harper ME
Redox biology 2025 Oct;86:103839
Redox biology 2025 Oct;86:103839
PSAT1 knockdown mediated VDAC1 oligomerization promotes ferroptosis and suppresses cell proliferation in esophageal squamous cell carcinoma.
Ren R, Fan T, Li Y, Li C, Jin F, Gao H, Wang X, Xu Y, Li X, Li S, Liu H
International journal of biological macromolecules 2025 Nov;330(Pt 4):148112
International journal of biological macromolecules 2025 Nov;330(Pt 4):148112
Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures.
Sha L, Wang Y, Meng P, Deng Y, Chen T, Zhang X, Ye Y, Xu Q
Nature chemical biology 2025 Nov;21(11):1742-1753
Nature chemical biology 2025 Nov;21(11):1742-1753
Oxidative stress reactivates androgen receptor signaling via USP36 to drive castration resistance in prostate cancer.
Fan C, Huang Z, Gao J, Gu Y, Wang N, Zhou B
Scientific reports 2025 Nov 26;15(1):42185
Scientific reports 2025 Nov 26;15(1):42185
m(6)A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability.
Huang F, Wang Y, Zhang X, Gao W, Li J, Yang Y, Mo H, Prince E, Long Y, Hu J, Jiang C, Kang Y, Chen Z, Hu YC, Zeng C, Yang L, Chen CW, Chen J, Huang H, Weng H
Nature communications 2025 May 6;16(1):4214
Nature communications 2025 May 6;16(1):4214
PLK1-mediated phosphorylation of PHGDH reprograms serine metabolism in advanced prostate cancer.
Rao X, Allison DB, Flight RM, Lin P, He D, Li Z, Zhang Y, Wang R, Li C, Wang J, Wang X, Peng J, Fong KW, Shao Q, Wang C, Ali ES, Moseley HN, Liu X
bioRxiv : the preprint server for biology 2025 May 24;
bioRxiv : the preprint server for biology 2025 May 24;
An in vivo screen identifies NAT10 as a master regulator of brain metastasis.
Chen JF, Xu P, Cai WL, Chen H, Wingrove E, Shi X, Li W, Biancon G, Zhang M, Balabaki A, Krop ED, Asare E, Zhang Y, Yin M, Tebaldi T, Meier JL, Westbrook TF, Halene S, Liu Y, Shen H, Nguyen DX, Yan Q
Science advances 2025 Mar 28;11(13):eads6021
Science advances 2025 Mar 28;11(13):eads6021
ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis.
Zhu J, Ren S, Yi Y, Wu Z, Lin H, Shan G, Huang X, Pan B, Hu Z, Sui Q, Zhan C, Wang S, Liang J
Cell & bioscience 2025 Jun 28;15(1):94
Cell & bioscience 2025 Jun 28;15(1):94
Kinesin-related genes stratified the prognosis and immune responses of clear cell renal cell carcinoma.
Zang W, Ge L, Hu X, Xu T, Zhang Z, Zhang Y, Song F
European journal of medical research 2025 Jul 14;30(1):621
European journal of medical research 2025 Jul 14;30(1):621
The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms.
González-García P, Jiménez-Sánchez L, Corral-Sarasa J, López-Herrador S, Torres-Rusillo S, Díaz-Casado ME, López LC
Communications medicine 2025 Jul 10;5(1):286
Communications medicine 2025 Jul 10;5(1):286
Bioinformatics analysis of PSAT1 loss identifies downstream pathways regulated in EGFR mutant NSCLC and a selective gene signature for predicting the risk of relapse.
Biyik-Sit R, Waigel S, Andreeva K, Rouchka E, Clem BF
Oncology letters 2025 Jan;29(1):9
Oncology letters 2025 Jan;29(1):9
Ailanthone targets the KMT2A-MEN1 complex to suppress lung metastasis of osteosarcoma.
Liang J, Qiao G, Zhang Y, Yuan Y, Liu Z, Jiang Y, Zhang Y, Deng Z, Yu L, Lin H, Ma L, Luo Y, Zhou Y, Hu H, Liu X, Zhang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156258
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156258
Bioinformatics analysis of ferroptosis-related hub genes and immunoinfiltration in myocardial ischemia/reperfusion following heart transplantation.
Zhang Y, Tang Q, Cui J, Li Y, Xu H, Qiu Z, Lei S, Xue R, Sun Q, Xia Z
BMC cardiovascular disorders 2025 Jan 10;25(1):16
BMC cardiovascular disorders 2025 Jan 10;25(1):16
Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3-dependent PDGFB signaling.
Tang R, Sun Y, Deng A, Liu J, Dai P, Chen J, Deng C, Liu H, Hai Y, Tong Y, Du YE, Liu M, Luo H
Cancer communications (London, England) 2025 Dec;45(12):1706-1733
Cancer communications (London, England) 2025 Dec;45(12):1706-1733
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury.
Novak JSS, Polak L, Baksh SC, Barrows DW, Schernthanner M, Jackson BT, Thompson EAN, Gola A, Abdusselamoglu MD, Bonny AR, Gonzales KAU, Brunner JS, Bridgeman AE, Stewart KS, Hidalgo L, Dela Cruz-Racelis J, Luo JD, Gur-Cohen S, Pasolli HA, Carroll TS, Finley LWS, Fuchs E
Cell metabolism 2025 Aug 5;37(8):1715-1731.e11
Cell metabolism 2025 Aug 5;37(8):1715-1731.e11
Tanshinone IIA alleviates pulmonary fibrosis by modulating glutamine metabolic reprogramming based on [U-(13)C(5)]-glutamine metabolic flux analysis.
Shan B, Guo C, Zhou H, Chen J
Journal of advanced research 2025 Apr;70:531-544
Journal of advanced research 2025 Apr;70:531-544
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
Liu Y, Cui F, Xu A, Wang B, Ma Y, Zhang Q, Sun Q, Zheng Y, Xue Y, Sun Y, Bian L
International journal of biological sciences 2024;20(11):4277-4296
International journal of biological sciences 2024;20(11):4277-4296
N6-methyladenosine modification of LATS2 promotes hepatoblastoma progression by inhibiting ferroptosis through the YAP1/ATF4/PSAT1 axis.
Zhu G, Xie Y, Bian Z, Ma J, Zhen N, Chen T, Zhu J, Mao S, Tang X, Liu L, Gu S, Ding M, Pan Q
International journal of biological sciences 2024;20(11):4146-4161
International journal of biological sciences 2024;20(11):4146-4161
PSAT1 mediated EMT of colorectal cancer cells by regulating Pl3K/AKT signaling pathway.
Wang M, Zhang H, Lu Z, Su W, Tan Y, Wang J, Jia X
Journal of Cancer 2024;15(10):3183-3198
Journal of Cancer 2024;15(10):3183-3198
Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype.
Gao ZJ, Fang H, Sun S, Liu SQ, Fang Z, Liu Z, Li B, Wang P, Sun SR, Meng XY, Wu Q, Chen CS
Theranostics 2024;14(8):3104-3126
Theranostics 2024;14(8):3104-3126
Prognostic Signature in Osteosarcoma Based on Amino Acid Metabolism-Associated Genes.
Feng L, Chen Y, Mei X, Wang L, Zhao W, Yao J
Cancer biotherapy & radiopharmaceuticals 2024 Sep;39(7):517-531
Cancer biotherapy & radiopharmaceuticals 2024 Sep;39(7):517-531
Metabolic adaptation in epithelial ovarian cancer metastasis.
Frederick MI, Nassef MZ, Borrelli MJ, Kuang S, Buensuceso A, More T, Cordes T, O'Donoghue P, Shepherd TG, Hiller K, Heinemann IU
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167312
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167312
Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.
Liu Y, Xun W, Zhao T, Huang M, Sun L, Wen G, Kang X, Wang J, Han T
Communications biology 2024 Oct 21;7(1):1365
Communications biology 2024 Oct 21;7(1):1365
PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress.
Du X, Wang Y, Gao F
Diagnostic pathology 2024 Oct 15;19(1):138
Diagnostic pathology 2024 Oct 15;19(1):138
l-2-Hydroxyglutarate remodeling of the epigenome and epitranscriptome creates a metabolic vulnerability in kidney cancer models.
Kundu A, Brinkley GJ, Nam H, Karki S, Kirkman R, Pandit M, Shim E, Widden H, Liu J, Heidarian Y, Mahmoudzadeh NH, Fitt AJ, Absher D, Ding HF, Crossman DK, Placzek WJ, Locasale JW, Rakheja D, McConathy JE, Ramachandran R, Bae S, Tennessen JM, Sudarshan S
The Journal of clinical investigation 2024 May 14;134(13)
The Journal of clinical investigation 2024 May 14;134(13)
CYP3A5 unexpectedly regulates glucose metabolism through the AKT-TXNIP-GLUT1 axis in pancreatic cancer.
Shao M, Pan Q, Tan H, Wu J, Lee HW, Huber AD, Wright WC, Cho JH, Yu J, Peng J, Chen T
Genes & diseases 2024 Jul;11(4):101079
Genes & diseases 2024 Jul;11(4):101079
PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells.
Wang L, Yan F, Shi Y, Su X, Zhang Y
Toxicology in vitro : an international journal published in association with BIBRA 2024 Feb;94:105711
Toxicology in vitro : an international journal published in association with BIBRA 2024 Feb;94:105711
Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis.
Xu F, Shen C, Zhang S, Liu Y, Liu D, Kuang Y, Li R, Wang C, Cai X, Shi M, Xiao Y
International immunopharmacology 2024 Feb 15;128:111433
International immunopharmacology 2024 Feb 15;128:111433
Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1 and blocking the binding of HMGB1 to the viral genome.
Hu P, Li H, Ji Z, Jing W, Li Z, Yu S, Shan X, Cui Y, Wang B, Dong H, Zhou Y, Wang Z, Xiong H, Zhang X, Li HC, Wang J, Tang J, Wang T, Xie K, Liu Y, Zhu H, Yu Q
PLoS pathogens 2024 Dec;20(12):e1012782
PLoS pathogens 2024 Dec;20(12):e1012782
BET inhibition induces GDH1-dependent glutamine metabolic remodeling and vulnerability in liver cancer.
Mi W, You J, Li L, Zhu L, Xia X, Yang L, Li F, Xu Y, Bi J, Liu P, Chen L, Li F
Life metabolism 2024 Aug;3(4):loae016
Life metabolism 2024 Aug;3(4):loae016
Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression.
Yamamoto T, Nakayama J, Urabe F, Ito K, Nishida-Aoki N, Kitagawa M, Yokoi A, Kuroda M, Hattori Y, Yamamoto Y, Ochiya T
Cell reports 2024 Aug 27;43(8):114517
Cell reports 2024 Aug 27;43(8):114517
A novel and ubiquitous miRNA-involved regulatory module ensures precise phosphorylation of RNA polymerase II and proper transcription.
Wang Z, Zhong S, Zhang S, Zhang B, Zheng Y, Sun Y, Zhang Q, Liu X
PLoS pathogens 2024 Apr;20(4):e1012138
PLoS pathogens 2024 Apr;20(4):e1012138
PSAT1 enhances the efficacy of the prognosis estimation nomogram model in stage-based clear cell renal cell carcinoma.
Wang J, He X, Mi Y, Chen YQ, Li J, Wang R
BMC cancer 2024 Apr 13;24(1):463
BMC cancer 2024 Apr 13;24(1):463
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
Yamamoto T, Hayashida T, Masugi Y, Oshikawa K, Hayakawa N, Itoh M, Nishime C, Suzuki M, Nagayama A, Kawai Y, Hishiki T, Matsuura T, Naito Y, Kubo A, Yamamoto A, Yoshioka Y, Kurahori T, Nagasaka M, Takizawa M, Takano N, Kawakami K, Sakamoto M, Wakui M, Yamamoto T, Kitagawa Y, Kabe Y, Horisawa K, Suzuki A, Matsumoto M, Suematsu M
Cancer research 2024 Apr 1;84(7):1065-1083
Cancer research 2024 Apr 1;84(7):1065-1083
Upregulation of serine metabolism enzyme PSAT1 predicts poor prognosis and promotes proliferation, metastasis and drug resistance of clear cell renal cell carcinoma.
Ye J, Huang X, Tian S, Wang J, Wang H, Feng H, Zhao X, Cao S, Xuan Y, Li X, Ma X, Huang Y, Zhang X
Experimental cell research 2024 Apr 1;437(1):113977
Experimental cell research 2024 Apr 1;437(1):113977
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Wang H, Lin F, Xu Z, Yu S, Li G, Liao S, Zhao W, Zhang F, Wang J, Wang S, Ouyang C, Zhang C, Xia H, Wu Y, Jiang B, Li Q
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556
Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth.
Tombari C, Zannini A, Bertolio R, Pedretti S, Audano M, Triboli L, Cancila V, Vacca D, Caputo M, Donzelli S, Segatto I, Vodret S, Piazza S, Rustighi A, Mantovani F, Belletti B, Baldassarre G, Blandino G, Tripodo C, Bicciato S, Mitro N, Del Sal G
Nature communications 2023 Oct 25;14(1):6777
Nature communications 2023 Oct 25;14(1):6777
Comparative multi-omic analyses of cardiac mitochondrial stress in three mouse models of frataxin deficiency.
Sayles NM, Napierala JS, Anrather J, Diedhiou N, Li J, Napierala M, Puccio H, Manfredi G
Disease models & mechanisms 2023 Oct 1;16(10)
Disease models & mechanisms 2023 Oct 1;16(10)
MicroRNA regulation of the serine synthesis pathway in endocrine-resistant breast cancer cells.
Petri BJ, Piell KM, Wilt AE, Howser AD, Winkler L, Whitworth MR, Valdes BL, Lehman NL, Clem BF, Klinge CM
Endocrine-related cancer 2023 Nov 1;30(11)
Endocrine-related cancer 2023 Nov 1;30(11)
Downregulation of PSAT1 inhibits cell proliferation and migration in uterine corpus endometrial carcinoma.
Wang M, Yue S, Yang Z
Scientific reports 2023 Mar 11;13(1):4081
Scientific reports 2023 Mar 11;13(1):4081
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Wu Y, Tang L, Huang H, Yu Q, Hu B, Wang G, Ge F, Yin T, Li S, Yu X
Nature communications 2023 Mar 10;14(1):1323
Nature communications 2023 Mar 10;14(1):1323
Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer.
Fan TW, Winnike J, Al-Attar A, Belshoff AC, Lorkiewicz PK, Tan JL, Wu M, Higashi RM, Lane AN
Metabolites 2023 Jun 21;13(7)
Metabolites 2023 Jun 21;13(7)
Comprehensive Analysis of Prognosis and Immune Landscapes Based on Lipid-Metabolism- and Ferroptosis-Associated Signature in Uterine Corpus Endometrial Carcinoma.
Yang P, Lu J, Zhang P, Zhang S
Diagnostics (Basel, Switzerland) 2023 Feb 24;13(5)
Diagnostics (Basel, Switzerland) 2023 Feb 24;13(5)
Cyclin D1 extensively reprograms metabolism to support biosynthetic pathways in hepatocytes.
Wu H, Kren BT, Lane AN, Cassel TA, Higashi RM, Fan TWM, Scaria GS, Shekels LL, Klein MA, Albrecht JH
The Journal of biological chemistry 2023 Dec;299(12):105407
The Journal of biological chemistry 2023 Dec;299(12):105407
Lycorine eliminates B-cell acute lymphoblastic leukemia cells by targeting PSAT1 through the serine/glycine metabolic pathway.
Liu Y, Du Z, Li T, Zhang J, Cheng Y, Huang J, Yang J, Wen L, Tian M, Yang M, Chen C
European journal of pharmacology 2023 Dec 15;961:176162
European journal of pharmacology 2023 Dec 15;961:176162
FGFR3 Alterations in Bladder Cancer Stimulate Serine Synthesis to Induce Immune-Inert Macrophages That Suppress T-cell Recruitment and Activation.
Ouyang Y, Ou Z, Zhong W, Yang J, Fu S, Ouyang N, Chen J, Xu L, Wu D, Qian J, Lin Y, Lin T, Huang J
Cancer research 2023 Dec 15;83(24):4030-4046
Cancer research 2023 Dec 15;83(24):4030-4046
Transcriptome and Proteome Analysis in LUHMES Cells Overexpressing Alpha-Synuclein.
Höllerhage M, Stepath M, Kohl M, Pfeiffer K, Chua OWH, Duan L, Hopfner F, Eisenacher M, Marcus K, Höglinger GU
Frontiers in neurology 2022;13:787059
Frontiers in neurology 2022;13:787059
Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway.
Zhang Y, Gong R, Liu Y, Sun X, Liang J, Zhou Y, Wang Y, Yu W, Wang Y, Tang L, He A, Shen Z, Yao Y, Hu H, Liu X, Zhang J
Frontiers in oncology 2022;12:842406
Frontiers in oncology 2022;12:842406
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
Li S, Yang H, Li W, Liu JY, Ren LW, Yang YH, Ge BB, Zhang YZ, Fu WQ, Zheng XJ, Du GH, Wang JH
Acta pharmacologica Sinica 2022 Oct;43(10):2709-2722
Acta pharmacologica Sinica 2022 Oct;43(10):2709-2722
Metabolic and Nonmetabolic Functions of PSAT1 Coordinate Signaling Cascades to Confer EGFR Inhibitor Resistance and Drive Progression in Lung Adenocarcinoma.
Luo MY, Zhou Y, Gu WM, Wang C, Shen NX, Dong JK, Lei HM, Tang YB, Liang Q, Zou JH, Xu L, Ma P, Zhuang G, Bi L, Xu L, Zhu L, Chen HZ, Shen Y
Cancer research 2022 Oct 4;82(19):3516-3531
Cancer research 2022 Oct 4;82(19):3516-3531
Single-cell analysis of human testis aging and correlation with elevated body mass index.
Nie X, Munyoki SK, Sukhwani M, Schmid N, Missel A, Emery BR, DonorConnect, Stukenborg JB, Mayerhofer A, Orwig KE, Aston KI, Hotaling JM, Cairns BR, Guo J
Developmental cell 2022 May 9;57(9):1160-1176.e5
Developmental cell 2022 May 9;57(9):1160-1176.e5
The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1.
Tang S, Cao Y, Cai Z, Nie X, Ruan J, Zhou Z, Ruan G, Zhu Z, Han W, Ding C
Science signaling 2022 May 24;15(735):eabm6265
Science signaling 2022 May 24;15(735):eabm6265
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.
Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G
Nature communications 2022 May 16;13(1):2698
Nature communications 2022 May 16;13(1):2698
PERK is a critical metabolic hub for immunosuppressive function in macrophages.
Raines LN, Zhao H, Wang Y, Chen HY, Gallart-Ayala H, Hsueh PC, Cao W, Koh Y, Alamonte-Loya A, Liu PS, Ivanisevic J, Lio CJ, Ho PC, Huang SC
Nature immunology 2022 Mar;23(3):431-445
Nature immunology 2022 Mar;23(3):431-445
Microneedle patches integrated with lateral flow cassettes for blood-free chronic kidney disease point-of-care testing during a pandemic.
Chen YJ, Hsu YP, Tain YL, Li NS, Pang HH, Kuo SW, Yang HW
Biosensors & bioelectronics 2022 Jul 15;208:114234
Biosensors & bioelectronics 2022 Jul 15;208:114234
Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1.
Dai W, Shen J, Yan J, Bott AJ, Maimouni S, Daguplo HQ, Wang Y, Khayati K, Guo JY, Zhang L, Wang Y, Valvezan A, Ding WX, Chen X, Su X, Gao S, Zong WX
The Journal of clinical investigation 2022 Dec 15;132(24)
The Journal of clinical investigation 2022 Dec 15;132(24)
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
Rome FI, Hughey CC
Molecular metabolism 2022 Apr;58:101452
Molecular metabolism 2022 Apr;58:101452
Monosaccharide-mediated rational synthesis of a universal plasmonic platform with broad spectral fluorescence enhancement for high-sensitivity cancer biomarker analysis.
Liu M, Li Y, Xing W, Zhang Y, Xie X, Pang J, Zhou F, Yang J
Journal of nanobiotechnology 2022 Apr 10;20(1):184
Journal of nanobiotechnology 2022 Apr 10;20(1):184
Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation.
Shen L, Hu P, Zhang Y, Ji Z, Shan X, Ni L, Ning N, Wang J, Tian H, Shui G, Yuan Y, Li G, Zheng H, Yang XP, Huang D, Feng X, Li MJ, Liu Z, Wang T, Yu Q
Cell metabolism 2021 May 4;33(5):971-987.e6
Cell metabolism 2021 May 4;33(5):971-987.e6
Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression.
Barnabas GD, Lee JS, Shami T, Harel M, Beck L, Selitrennik M, Jerby-Arnon L, Erez N, Ruppin E, Geiger T
Cancer research 2021 Mar 15;81(6):1443-1456
Cancer research 2021 Mar 15;81(6):1443-1456
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.
Gheller BJ, Blum JE, Lim EW, Handzlik MK, Hannah Fong EH, Ko AC, Khanna S, Gheller ME, Bender EL, Alexander MS, Stover PJ, Field MS, Cosgrove BD, Metallo CM, Thalacker-Mercer AE
Molecular metabolism 2021 Jan;43:101106
Molecular metabolism 2021 Jan;43:101106
Serine synthesis influences tamoxifen response in ER+ human breast carcinoma.
Metcalf S, Petri BJ, Kruer T, Green B, Dougherty S, Wittliff JL, Klinge CM, Clem BF
Endocrine-related cancer 2021 Jan;28(1):27-37
Endocrine-related cancer 2021 Jan;28(1):27-37
Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16.
Yang RL, Huang HM, Han CS, Cui SJ, Zhou YK, Zhou YH
Journal of dental research 2021 Jan;100(1):90-97
Journal of dental research 2021 Jan;100(1):90-97
Proteomic profile of human dental follicle stem cells and apical papilla stem cells.
Lei T, Zhang X, Chen P, Li Q, Du H
Journal of proteomics 2021 Jan 16;231:103928
Journal of proteomics 2021 Jan 16;231:103928
LncRNA MEG8 promotes NSCLC progression by modulating the miR-15a-5p-miR-15b-5p/PSAT1 axis.
Guo K, Qi D, Huang B
Cancer cell international 2021 Feb 1;21(1):84
Cancer cell international 2021 Feb 1;21(1):84
Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells.
Biyik-Sit R, Kruer T, Dougherty S, Bradley JA, Wilkey DW, Merchant ML, Trent JO, Clem BF
Cancers 2021 Aug 4;13(16)
Cancers 2021 Aug 4;13(16)
Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism.
Tandon M, Othman AH, Winogradzki M, Pratap J
Gene 2021 Apr 5;775:145419
Gene 2021 Apr 5;775:145419
PSAT1 Regulated Oxidation-Reduction Balance Affects the Growth and Prognosis of Epithelial Ovarian Cancer.
Zhang Y, Li J, Dong X, Meng D, Zhi X, Yuan L, Yao L
OncoTargets and therapy 2020;13:5443-5453
OncoTargets and therapy 2020;13:5443-5453
TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
O'Leary EM, Tian Y, Nigdelioglu R, Witt LJ, Cetin-Atalay R, Meliton AY, Woods PS, Kimmig LM, Sun KA, Gökalp GA, Mutlu GM, Hamanaka RB
American journal of respiratory cell and molecular biology 2020 Nov;63(5):601-612
American journal of respiratory cell and molecular biology 2020 Nov;63(5):601-612
Overexpression of PSAT1 promotes metastasis of lung adenocarcinoma by suppressing the IRF1-IFNγ axis.
Chan YC, Chang YC, Chuang HH, Yang YC, Lin YF, Huang MS, Hsiao M, Yang CJ, Hua KT
Oncogene 2020 Mar;39(12):2509-2522
Oncogene 2020 Mar;39(12):2509-2522
Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis.
Zhang J, Yang J, Yang N, Ma J, Lu D, Dong Y, Liang H, Liu D, Cang M
Lipids in health and disease 2020 Mar 13;19(1):39
Lipids in health and disease 2020 Mar 13;19(1):39
Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer.
Metcalf S, Dougherty S, Kruer T, Hasan N, Biyik-Sit R, Reynolds L, Clem BF
Clinical & experimental metastasis 2020 Feb;37(1):187-197
Clinical & experimental metastasis 2020 Feb;37(1):187-197
The auxiliary diagnostic value of prostate-specific antigen and α-methylacyl-CoA racemase in prostate cancer.
Yang D, Shi X, Lei Y, Zhou X, Chen Q
Oncology letters 2020 Aug;20(2):1418-1422
Oncology letters 2020 Aug;20(2):1418-1422
SOX2 has dual functions as a regulator in the progression of neuroendocrine prostate cancer.
Li H, Wang L, Li Z, Geng X, Li M, Tang Q, Wu C, Lu Z
Laboratory investigation; a journal of technical methods and pathology 2020 Apr;100(4):570-582
Laboratory investigation; a journal of technical methods and pathology 2020 Apr;100(4):570-582
The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.
Sinha T, Naash MI, Al-Ubaidi MR
iScience 2020 Apr 24;23(4):101004
iScience 2020 Apr 24;23(4):101004
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.
Fan TWM, Bruntz RC, Yang Y, Song H, Chernyavskaya Y, Deng P, Zhang Y, Shah PP, Beverly LJ, Qi Z, Mahan AL, Higashi RM, Dang CV, Lane AN
The Journal of biological chemistry 2019 Sep 6;294(36):13464-13477
The Journal of biological chemistry 2019 Sep 6;294(36):13464-13477
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X, Gao P
Life science alliance 2019 Oct;2(5)
Life science alliance 2019 Oct;2(5)
Glutamine Anabolism Plays a Critical Role in Pancreatic Cancer by Coupling Carbon and Nitrogen Metabolism.
Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy DJ, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson DA, Zong WX
Cell reports 2019 Oct 29;29(5):1287-1298.e6
Cell reports 2019 Oct 29;29(5):1287-1298.e6
Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Hamanaka RB, O'Leary EM, Witt LJ, Tian Y, Gökalp GA, Meliton AY, Dulin NO, Mutlu GM
American journal of respiratory cell and molecular biology 2019 Nov;61(5):597-606
American journal of respiratory cell and molecular biology 2019 Nov;61(5):597-606
Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.
Zeng H, Castillo-Cabrera J, Manser M, Lu B, Yang Z, Strande V, Begue D, Zamponi R, Qiu S, Sigoillot F, Wang Q, Lindeman A, Reece-Hoyes JS, Russ C, Bonenfant D, Jiang X, Wang Y, Cong F
eLife 2019 Nov 19;8
eLife 2019 Nov 19;8
The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.
Xu L, Wang L, Zhou L, Dorfman RG, Pan Y, Tang D, Wang Y, Yin Y, Jiang C, Zou X, Wu J, Zhang M
Neoplasia (New York, N.Y.) 2019 May;21(5):429-441
Neoplasia (New York, N.Y.) 2019 May;21(5):429-441
A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.
Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H
FEBS letters 2019 Apr;593(8):763-776
FEBS letters 2019 Apr;593(8):763-776
Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner.
Wang YQ, Wang HL, Xu J, Tan J, Fu LN, Wang JL, Zou TH, Sun DF, Gao QY, Chen YX, Fang JY
Nature communications 2018 Feb 7;9(1):545
Nature communications 2018 Feb 7;9(1):545
Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice.
Zhou X, He L, Wu C, Zhang Y, Wu X, Yin Y
Molecular nutrition & food research 2017 Nov;61(11)
Molecular nutrition & food research 2017 Nov;61(11)
Serine Is an Essential Metabolite for Effector T Cell Expansion.
Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer ML, Verway MJ, Raissi TC, Tsui H, Boukhaled G, Henriques da Costa S, Frezza C, Krawczyk CM, Friedman A, Manfredi M, Richer MJ, Hess C, Jones RG
Cell metabolism 2017 Feb 7;25(2):345-357
Cell metabolism 2017 Feb 7;25(2):345-357
A simple method based on Sanger sequencing and MS Word wildcard searching to identify Cas9-induced frameshift mutations.
Jie H, Li Z, Wang P, Zhao L, Zhang Q, Yao X, Song X, Zhao Y, Yao S
Laboratory investigation; a journal of technical methods and pathology 2017 Dec;97(12):1500-1507
Laboratory investigation; a journal of technical methods and pathology 2017 Dec;97(12):1500-1507
Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro.
Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, Nishida H, Inoue T, Taguchi A, Ogishima J, Eguchi S, Yamashita A, Tomio K, Wada-Hiraike O, Oda K, Nagamatsu T, Osuga Y, Fujii T
International journal of oncology 2017 Apr;50(4):1431-1438
International journal of oncology 2017 Apr;50(4):1431-1438
Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma.
Liu B, Jia Y, Cao Y, Wu S, Jiang H, Sun X, Ma J, Yin X, Mao A, Shang M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(1):395-406
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;39(1):395-406
Stem cell function and stress response are controlled by protein synthesis.
Blanco S, Bandiera R, Popis M, Hussain S, Lombard P, Aleksic J, Sajini A, Tanna H, Cortés-Garrido R, Gkatza N, Dietmann S, Frye M
Nature 2016 Jun 16;534(7607):335-40
Nature 2016 Jun 16;534(7607):335-40
MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1.
Yan S, Jiang H, Fang S, Yin F, Wang Z, Jia Y, Sun X, Wu S, Jiang T, Mao A
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;37(1):375-86
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2015;37(1):375-86
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44
Cell research 2015 Apr;25(4):429-44
Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific biomarkers.
Toyama A, Suzuki A, Shimada T, Aoki C, Aoki Y, Umino Y, Nakamura Y, Aoki D, Sato TA
Cancer science 2012 Apr;103(4):747-55
Cancer science 2012 Apr;103(4):747-55
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10501-1-AP( PSAT1 Antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PSAT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PSAT1. This antibody recognizes human antigen. The PSAT1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
