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Western blot
Immunocytochemistry
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- 650601 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#650601, RRID:AB_10896795
- Product name
- Purified anti-Bcl11b
- Antibody type
- Monoclonal
- Antigen
- Human Bcl11b
- Description
- The transcription factor Bcl11b is expressed in thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro, and effectively prevented tumor metastasis in vivo. Therefore, ITNKs may represent a new cell source for cell-based therapies.
- Reactivity
- Human, Mouse, Zebrafish
- Host
- Rat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 25 µg
- Concentration
- 0.5 mg/ml
- Storage
- Upon receipt, store undiluted at 4°C.
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Jurkat cells were stained with anti-bcl11b, clone 25B6 (1:200 dilution), and tubulin-a clone TU-01, followed by DyLight⢠549 conjugated anti-rat IgG and DyLight⢠488 conjugated anti-mouse IgG. Nuclei are stained with DAPI.
- Conjugate
- Unconjugated
