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- References [20]
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- Product number
- 25070-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- OTUD4 antibody
- Antibody type
- Polyclonal
- Description
- OTUD4 antibody (Cat. #25070-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The ovarian tumor domain-containing protein 4 (OTUD4)-targeted ferroptosis inhibitor Maclekarpine E attenuates ulcerative colitis.
WSB1 promotes prostate cancer malignancy through OTUD4-mediated ISOC2 stabilization and P16INK4a suppression.
The deubiquitinase OTUD4 suppresses TAK1 kinase-dependent NF-κB signaling and inflammation.
The DIAPH3/RPL6 axis regulates the cGAS-STING pathway in pancreatic cancer.
PPDPF-mediated regulation of BCAA metabolism enhances mTORC1 activity and drives cholangiocarcinoma progression.
OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression.
Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression.
Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway.
Combinatorial ubiquitin code degrades deubiquitylation-protected substrates.
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B(1) cytotoxicity.
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy.
NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma.
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases.
Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1.
Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells.
A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
N(6)-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors.
MiR-103a-3p Promotes Zika Virus Replication by Targeting OTU Deubiquitinase 4 to Activate p38 Mitogen-Activated Protein Kinase Signaling Pathway.
Lv X, He Z, Xue J, Yang Y, Tang Y, Cai H, Luo H, Li X, Dong Z, Liu Y, Zeng J, Yang Z, Cheng P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157999
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:157999
WSB1 promotes prostate cancer malignancy through OTUD4-mediated ISOC2 stabilization and P16INK4a suppression.
Sun J, Wang F, Feng Y, Qiu X, Qu W, He X, Xie J, Li G
American journal of cancer research 2025;15(10):4434-4451
American journal of cancer research 2025;15(10):4434-4451
The deubiquitinase OTUD4 suppresses TAK1 kinase-dependent NF-κB signaling and inflammation.
Liu Z, Wang X, Wu L, Min L, Sheng Y, Sun Z, Deng Y, Miao L, Liu Y, Li J, Zhao Y
The Journal of biological chemistry 2025 Nov;301(11):110784
The Journal of biological chemistry 2025 Nov;301(11):110784
The DIAPH3/RPL6 axis regulates the cGAS-STING pathway in pancreatic cancer.
Huang H, Lin C, Zhou C, Cui L, Rong Y
European journal of medical research 2025 Nov 29;31(1):9
European journal of medical research 2025 Nov 29;31(1):9
PPDPF-mediated regulation of BCAA metabolism enhances mTORC1 activity and drives cholangiocarcinoma progression.
Li Z, Guan Y, Gao J, Zhu L, Zeng Z, Jing Q, Wan Q, Fan Q, Ren X, Pei H, Zhang D, Rong Y, Rong Z, He J, Zhang Y, Li N, Chen P, Sun L, Xu B, Nie Y, Deng Y
Oncogene 2025 May;44(19):1415-1433
Oncogene 2025 May;44(19):1415-1433
OTUD4 inhibits ferroptosis by stabilizing GPX4 and suppressing autophagic degradation to promote tumor progression.
Chen J, Huang C, Mei J, Lin Q, Chen W, Tang J, Wei X, Mo C, Zhang Y, Zeng Q, Mo X, Tang W, Luo T
Cell reports 2025 May 27;44(5):115681
Cell reports 2025 May 27;44(5):115681
Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression.
Liu N, Ma Y, Gong W, Shao X, Shi T, Li L, Wu W, Chen X, Shi Y, Zhang P, Lin J, Wang C, Fang D, Yang L, Wang P, Gao W, He Y, An X, Du R, Chen Y, Liu B, Qin J, Chen D, Cai P, Jiang Q, Guo B
Nature communications 2025 May 22;16(1):4746
Nature communications 2025 May 22;16(1):4746
Elevated SPARC Disrupts the Intestinal Barrier Integrity in Crohn's Disease by Interacting with OTUD4 and Activating the MYD88/NF-κB Pathway.
Wang J, He Y, Zhu X, Zhu J, Deng Z, Zhang H, Chen Y, Zhang G, Shi T, Chen W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2409419
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2409419
Combinatorial ubiquitin code degrades deubiquitylation-protected substrates.
Morita M, Takao M, Tokuhisa H, Chiba R, Tomomatsu S, Akizuki Y, Tomita T, Endo A, Saeki Y, Sato Y, Ohtake F
Nature communications 2025 Mar 24;16(1):2496
Nature communications 2025 Mar 24;16(1):2496
CRISPR screening identifies protein methylation and ubiquitination modifications that modulate aflatoxin B(1) cytotoxicity.
Yang H, Ji X, Zhong H, Yang X, Hu D, Cai G, Wu Z
Science China. Life sciences 2025 Jul;68(7):2121-2136
Science China. Life sciences 2025 Jul;68(7):2121-2136
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
Zhang D, Song S, Lin J, Ye T, Yang X, Jiang Q, Mi Y, Zhang M, Ge X, Shen Y, Du P, Shi Y, Zhang X, Li L, Zhang Y, Ding L, Liu J, Zhang Y, Gao S, Ye Q
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy.
Wang S, Tian X, Zhong Y, Xie X, Gao M, Zhang C, Cheng X, Qi Y, Zhong B, Feng P, Lan K, Zhang J
PLoS pathogens 2025 Apr;21(4):e1013052
PLoS pathogens 2025 Apr;21(4):e1013052
NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma.
Hu S, Yuan Y, Yan R, Xie H, Cai R, Xu J
Biochemical and biophysical research communications 2024 May 14;708:149798
Biochemical and biophysical research communications 2024 May 14;708:149798
OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.
Ci M, Zhao G, Li C, Liu R, Hu X, Pan J, Shen Y, Zhang G, Li Y, Zhang L, Liang P, Cui H
Cell death & disease 2024 Mar 1;15(3):179
Cell death & disease 2024 Mar 1;15(3):179
Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases.
Wang S, Tian X, Zhou Y, Xie J, Gao M, Zhong Y, Zhang C, Yu K, Bai L, Qin Q, Zhong B, Lin D, Feng P, Lan K, Zhang J
PLoS pathogens 2024 Jan;20(1):e1011943
PLoS pathogens 2024 Jan;20(1):e1011943
Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1.
Ma X, Wan R, Wen Y, Liu T, Song Y, Zhu Y
Experimental cell research 2024 Jan 1;434(1):113864
Experimental cell research 2024 Jan 1;434(1):113864
Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells.
Li Z, Tian Y, Zong H, Wang X, Li D, Keranmu A, Xin S, Ye B, Bai R, Chen W, Yang G, Ye L, Wang S
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1051-1069
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1051-1069
A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.
Wang P, Hu Z, Yu S, Su S, Wu R, Chen C, Ye Y, Wang H, Ye X, Zhou Z, Zhou S, Ren N
Cancer letters 2024 Aug 28;598:217092
Cancer letters 2024 Aug 28;598:217092
N(6)-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors.
Gao Z, Li C, Sun H, Bian Y, Cui Z, Wang N, Wang Z, Yang Y, Liu Z, He Z, Li B, Li F, Li Z, Wang L, Zhang D, Yang L, Xu Z, Li X, Xu H
Cell death and differentiation 2023 Feb;30(2):544-559
Cell death and differentiation 2023 Feb;30(2):544-559
MiR-103a-3p Promotes Zika Virus Replication by Targeting OTU Deubiquitinase 4 to Activate p38 Mitogen-Activated Protein Kinase Signaling Pathway.
Ye H, Kang L, Yan X, Li S, Huang Y, Mu R, Duan X, Chen L
Frontiers in microbiology 2022;13:862580
Frontiers in microbiology 2022;13:862580
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 25070-1-AP( OTUD4 Antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The OTUD4 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human OTUD4. This antibody recognizes human antigen. The OTUD4 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
