10193-2-AP

antibody from Proteintech Group

Targeting: RCN2 E6BP, ERC-55, ERC55, TCBP49

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

10193-2-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#10193-2-AP, RRID:AB_2180018

Product name

RCN2 antibody

Antibody type

Polyclonal

Description

KD/KO validated RCN2 antibody (Cat. #10193-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

TAG-PL: A Universal Proximity Labeling Platform for Mapping Mitochondrial Proteomes and Organelle Interactions under Stress.

Miao E, Yue X, Tao Z, Qin H, Ye M
Journal of proteome research 2026 Feb 6;25(2):966-977

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Reticulocalbin-2 in the Hippocampus Improves Cognitive Function of Diabetic Mice.

Zhang T, Tang S, Cheng J, Hu B, Xie LQ, Cheng Y, Chen X, Xie G
Brain and behavior 2026 Apr;16(4):e71336

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A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations.

Smart AD, Hughes ME, Ruiz Velasco AD, Hori N, Stolnik S, Jopling CL
Molecular therapy. Nucleic acids 2025 Sep 9;36(3):102602

---

Hepatitis B virus is a stealth virus that minimizes proteomic and secretomic changes in primary human hepatocytes.

Štaflová K, Clarová K, Doležal M, Hubálek M, Křenková A, Hodek J, Pichová I, Zábranský A
The Journal of general virology 2025 Nov;106(11)

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Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity.

Xie LQ, Hu B, Lu RB, Cheng YL, Chen X, Wen J, Xiao Y, An YZ, Peng N, Dai Y, Xie G, Guo Q, Peng H, Luo XH
Cell research 2025 Mar;35(3):165-185

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Integrative multi-omics analysis reveals a novel subtype of hepatocellular carcinoma with biological and clinical relevance.

Li S, Lin Y, Gao X, Zeng D, Cen W, Su Y, Su J, Zeng C, Huang Z, Zeng H, Huang S, Tang M, Li X, Luo M, Huang Z, Liang R, Ye J
Frontiers in immunology 2024;15:1517312

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Excessive mechanical loading promotes osteoarthritis development by upregulating Rcn2.

Liu Y, Chen P, Hu B, Xiao Y, Su T, Luo X, Tu M, Cai G
Biochimica et biophysica acta. Molecular basis of disease 2024 Aug;1870(6):167251

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RCN2 promotes Nasopharyngeal carcinoma progression by curbing Calcium flow and Mitochondrial apoptosis.

Yao H, Zhang S, Xie H, Fan Y, Miao M, Zhu R, Yuan L, Gu M, You Y, You B
Cellular oncology (Dordrecht, Netherlands) 2023 Aug;46(4):1031-1048

---

Reticulocalbin 2 as a Potential Biomarker and Therapeutic Target for Atherosclerosis.

Li J, Taylor AM, Manichaikul A, Angle JF, Shi W
Cells 2022 Mar 25;11(7)

---

A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis.

Peng H, Hu B, Xie LQ, Su T, Li CJ, Liu Y, Yang M, Xiao Y, Feng X, Zhou R, Guo Q, Zhou HY, Huang Y, Jiang TJ, Luo XH
Cell metabolism 2022 Aug 2;34(8):1168-1182.e6

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YY1-mediated reticulocalbin-2 upregulation promotes the hepatocellular carcinoma progression via activating MYC signaling.

Mei C, Jiang X, Gu Y, Wu X, Ma W, Chen X, Wang G, Yao Y, Liu Y, Zhang Z, Yuan Y
American journal of cancer research 2021;11(5):2238-2251

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Loss of reticulocalbin 2 lowers blood pressure and restrains ANG II-induced hypertension in vivo.

Li J, Cechova S, Wang L, Isakson BE, Le TH, Shi W
American journal of physiology. Renal physiology 2019 Jun 1;316(6):F1141-F1150

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Reticulocalbin 2 correlates with recurrence and prognosis in colorectal cancer.

Wang G, Wang Q, Fan Y, He X
American journal of cancer research 2017;7(11):2169-2179

---

Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking.

Kaewsapsak P, Shechner DM, Mallard W, Rinn JL, Ting AY
eLife 2017 Dec 14;6

---

Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation.

Hung V, Lam SS, Udeshi ND, Svinkina T, Guzman G, Mootha VK, Carr SA, Ting AY
eLife 2017 Apr 25;6

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Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors.

Nakakido M, Tamura K, Chung S, Ueda K, Fujii R, Kiyotani K, Nakamura Y
International journal of oncology 2016 Sep;49(3):868-76

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Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.

Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, Takahashi N, Iwanari H, Mochizuki Y, Hamakubo T, Imoto K, Meijer D, Watanabe M, Fukata M
Nature medicine 2015 Jan;21(1):19-26

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Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression.

Manichaikul A, Wang Q, Shi YL, Zhang Z, Leitinger N, Shi W
American journal of physiology. Heart and circulatory physiology 2011 Sep;301(3):H1056-61

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Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation.

Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Kwon SW, Zhao Y, Li J, Jin Y
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 26;107(4):1402-7

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

human brain tissue were subjected to SDS PAGE followed by western blot with 10193-2-AP(RCN2 antibody) at dilution of 1:400

Sample type

tissue

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of HepG2 cells, using RCN2 antibody 10193-2-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human gliomas using 10193-2-AP(RCN2 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue